PSMA6 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science PSMA6 Rabbit pAb Catalog No.: A13536 Basic Information Background Catalog No. The proteasome is a multicatalytic proteinase complex with a highly ordered ring- A13536 shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta Observed MW subunits. Proteasomes are distributed throughout eukaryotic cells at a high 27kDa concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non- lysosomal pathway. An essential function of a modified proteasome, the Calculated MW immunoproteasome, is the processing of class I MHC peptides. This gene encodes a 18kDa/25kDa/27kDa member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A Category pseudogene has been identified on the Y chromosome. Primary antibody Applications WB,IHC,IF Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 5687 P60900 IHC 1:50 - 1:200 Immunogen 1:50 - 1:200 IF Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human PSMA6 (NP_002782.1). Synonyms PSMA6;IOTA;PROS27;p27K Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using PSMA6 antibody (A13536) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- Immunofluorescence analysis of MCF-7 embedded human lung cancer using embedded mouse kidney using PSMA6 cells using PSMA6 antibody (A13536). Blue: PSMA6 antibody (A13536) at dilution of antibody (A13536) at dilution of 1:100 (40x DAPI for nuclear staining. 1:100 (40x lens). lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Genetic Variations in the PSMA6 and PSMC6 Proteasome Genes Are Associated with Multiple Sclerosis and Response to Interferon‑Β Therapy in Latvians
EXPERIMENTAL AND THERAPEUTIC MEDICINE 21: 478, 2021 Genetic variations in the PSMA6 and PSMC6 proteasome genes are associated with multiple sclerosis and response to interferon‑β therapy in Latvians NATALIA PARAMONOVA1, JOLANTA KALNINA1, KRISTINE DOKANE1, KRISTINE DISLERE1, ILVA TRAPINA1, TATJANA SJAKSTE1 and NIKOLAJS SJAKSTE1,2 1Genomics and Bioinformatics, Institute of Biology of The University of Latvia; 2Department of Medical Biochemistry of The University of Latvia, LV‑1004 Riga, Latvia Received July 8, 2020; Accepted December 8, 2020 DOI: 10.3892/etm.2021.9909 Abstract. Several polymorphisms in genes related to the Introduction ubiquitin‑proteasome system exhibit an association with pathogenesis and prognosis of various human autoimmune Multiple sclerosis (MS) is a lifelong demyelinating disease of diseases. Our previous study reported the association the central nervous system. The clinical onset of MS tends to between multiple sclerosis (MS) and the PSMA3‑rs2348071 be between the second and fourth decade of life. Similarly to polymorphism in the Latvian population. The current study other autoimmune diseases, women are affected 3‑4 times more aimed to evaluate the PSMA6 and PSMC6 genetic variations, frequently than men (1). About 10% of MS patients experience their interaction between each other and with the rs2348071, a primary progressive MS form characterized by the progres‑ on the susceptibility to MS risk and response to therapy in sion of neurological disability from the onset. In about 90% the Latvian population. PSMA6‑rs2277460, ‑rs1048990 and of MS patients, the disease undergoes the relapse‑remitting PSMC6‑rs2295826, ‑rs2295827 were genotyped in the MS MS course (RRMS); in most of these patients, the condition case/control study and analysed in terms of genotype‑protein acquires secondary progressive course (SPMS) (2).
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Overexpression of Androgen Receptor in Prostate Cancer
ALFONSO URBANUCCI Overexpression of Androgen Receptor in Prostate Cancer ACADEMIC DISSERTATION To be presented, with the permission of the board of Institute of Biomedical Technology of the University of Tampere, for public discussion in the Jarmo Visakorpi Auditorium, of the Arvo Building, Lääkärinkatu 1, Tampere, on January 20th, 2012, at 12 o’clock. UNIVERSITY OF TAMPERE ACADEMIC DISSERTATION University of Tampere, Institute of Biomedical Technology and BioMediTech Tampere University Hospital, Laboratory Centre Graduate Program in Biomedicine and Biotechnology (TGPBB) Finland Supervised by Reviewed by Professor Tapio Visakorpi Docent Auli Karhu University of Tampere University of Helsinki Finland Finland Docent Noora Kotaja University of Turku Finland Copyright ©2012 Tampere University Press and the author Distribution Tel. +358 40 190 9800 Bookshop TAJU Fax +358 3 3551 7685 P.O. Box 617 [email protected] 33014 University of Tampere www.uta.fi/taju Finland http://granum.uta.fi Cover design by Mikko Reinikka Acta Universitatis Tamperensis 1693 Acta Electronica Universitatis Tamperensis 1159 ISBN 978-951-44-8685-2 (print) ISBN 978-951-44-8686-9 (pdf) ISSN-L 1455-1616 ISSN 1456-954X ISSN 1455-1616 http://acta.uta.fi Tampereen Yliopistopaino Oy – Juvenes Print Tampere 2012 CONTENTS ABBREVIATIONS ..................................................................................................... 5 ABSTRACT ................................................................................................................ 7 SINTESI .....................................................................................................................
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Datasheet: VMA00472KT Product Details
Datasheet: VMA00472KT Description: PSMA6 ANTIBODY WITH CONTROL LYSATE Specificity: PSMA6 Format: Purified Product Type: PrecisionAb™ Monoclonal Clone: 7C2 Isotype: IgG1 Quantity: 2 Westerns Product Details Applications This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit www.bio-rad-antibodies.com/protocols. Yes No Not Determined Suggested Dilution Western Blotting 1/1000 PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type. Target Species Human Species Cross Reacts with: Mouse, Rat Reactivity N.B. Antibody reactivity and working conditions may vary between species. Product Form Purified IgG - liquid Preparation 20μl Mouse monoclonal antibody purified by affinity chromatography on Protein G from ascites Buffer Solution Phosphate buffered saline Preservative 0.09% Sodium Azide (NaN3) Stabilisers 1% Bovine Serum Albumin 50% Glycerol Immunogen Full length recombinant protein of human PSMA6 produced in E. Coli External Database Links UniProt: P60900 Related reagents Entrez Gene: 5687 PSMA6 Related reagents Page 1 of 3 Synonyms PROS27 Specificity Mouse anti Human PSMA6 antibody recognizes the PSMA6, also known as 27 kDa prosomal protein, PROS-27, macropain iota chain, multicatalytic endopeptidase complex iota chain, prosomal P27K protein, proteasome iota chain, proteasome subunit alpha type-6 or proteasome subunit iota.
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Table 1. Swine Proteins Identified As Differentially Expressed at 24Dpi in OURT 88/3 Infected Animals
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R Graphics Output
Running Enrichment Score (RES) −1.5 −1.0 −0.5 0.0 0 "G1[B_Nov]" "G1[B_Nov]" 2000 Number ofgenes: 12930(inlist),30geneset) Gene Set1734:PROTEASOME Zero crossingat6822 4000 Gene ListIndex 6000 Peak at9598 Peak 8000 10000 "G2[Non_B_Nov]" "G2[Non_B_Nov]" 12000 P(ES) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 −1.0 Neg. ES "G2[Non_B_Nov]" Neg. ES"G2[Non_B_Nov]" ES = −0.678 NES = −1.43 Nom. p−val= 0.165FWER=1FDR=0.315 ES =−0.678NES =−1.43Nom.p−val= −0.5 Gene SetNullDistribution 0.0 ES Observed GeneSetESvalue Gene SetNullDensity Pos. ES: "G1[B_Nov]" ES:"G1[B_Nov]" Pos. 0.5 1.0 PSMD14 PSMD11 PSMD13 PSMD12 PSMB3 PSMD4 PSMD2 PSMA3 PSMD7 PSMA7 PSMC6 PSMB5 PSMA4 PSMB1 PSMB6 PSMC5 PSMA6 PSMB4 PSMD8 PSMB2 PSMA5 PSMD6 PSMC1 PSMC4 PSMA1 PSMC2 PSMA2 PSMC3 PSMB7 PSMD3 Class G1[B_Nov] JD0396.ALL.v5.U133A.CEL JD0108.ALL.v5.U133A.CEL JD0146.ALL.v5.U133A.CEL JD0360.ALL.v5.U133A.CEL JD0367.ALL.v5.U133A.CEL JD0314.ALL.v5.U133A.CEL JD0420.ALL.v5.U133A.CEL JD0343.ALL.v5.U133A.CEL JD0173.ALL.v5.U133A.CEL JD0258.ALL.v5.U133A.CEL JD0287.ALL.v5.U133A.CEL JD0181.ALL.v5.U133A.CEL JD.ALD509.v5.U133A.CEL JD0239.ALL.v5.U133A.CEL JD0186B.ALL.v5.U133A.CEL JD0032.ALL.v5.U133A.CEL JD0361.ALL.v5.U133A.CEL JD0336.ALL.v5.U133A.CEL JD0300.RR.ALL.v5.U133A.CEL JD0267.ALL.v5.U133A.CEL JD0323.ALL.v5.U133A.CEL JD0150.ALL.v5.U133A.CEL JD0059.ALL.v5.U133A.CEL JD0123.ALL.v5.U133A.CEL JD0056.ALL.v5.U133A.CEL JD0058.ALL.v5.U133A.CEL JD0139.ALL.v5.U133A.CEL JD0107.ALL.v5.U133A.CEL JD0109.ALL.v5.U133A.CEL GenesinGeneSet HeatMapfor JD0085.ALL.v5.U133A.CEL JD0253.ALL.v5.U133A.CEL JD0426.ALL.v5.U133A.CEL JD0286.ALL.v5.U133A.CEL
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Datasheet: VMA00472 Product Details
Datasheet: VMA00472 Description: MOUSE ANTI PSMA6 Specificity: PSMA6 Format: Purified Product Type: PrecisionAb™ Monoclonal Clone: 7C2 Isotype: IgG1 Quantity: 100 µl Product Details Applications This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit www.bio-rad-antibodies.com/protocols. Yes No Not Determined Suggested Dilution Western Blotting 1/1000 PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type. Target Species Human Species Cross Reacts with: Mouse, Rat Reactivity N.B. Antibody reactivity and working conditions may vary between species. Product Form Purified IgG - liquid Preparation Purified IgG prepared by affinity chromatography on Protein G from ascites Buffer Solution Phosphate buffered saline Preservative 0.09% Sodium Azide (NaN3) Stabilisers 1% Bovine Serum Albumin 50% Glycerol Immunogen Full length recombinant protein of human PSMA6 produced in E. Coli External Database Links UniProt: P60900 Related reagents Entrez Gene: 5687 PSMA6 Related reagents Page 1 of 2 Synonyms PROS27 Specificity Mouse anti Human PSMA6 antibody recognizes the PSMA6, also known as 27 kDa prosomal protein, PROS-27, macropain iota chain, multicatalytic endopeptidase complex iota chain, prosomal P27K protein, proteasome iota chain, proteasome subunit alpha type-6 or proteasome subunit iota.
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COLON CANCER AND ITS MOLECULAR SUBSYSTEMS: NETWORK APPROACHES TO DISSECTING DRIVER GENE BIOLOGY by VISHAL N. PATEL Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Genetics CASE WESTERN RESERVE UNIVERSITY August 2011 Case Western Reserve University School of Graduate Studies We hereby approve the dissertation* of Vishal N. Patel, candidate for the degree of Doctor of Philosophy on July 6, 2011. Committee Chair: Georgia Wiesner Mark R. Chance Sudha Iyengar Mehmet Koyuturk * We also certify that written approval has been obtained for any proprietary material contained therein 2 Table of Contents I. List of Tables 6 II. List of Figures 7 III. List of Abbreviations 8 IV. Glossary 10 V. Abstract 14 VI. Colon Cancer and its Molecular Subsystems 15 Construction, Interpretation, and Validation a. Colon Cancer i. Etiology ii. Development iii. The Pathway Paradigm iv. Cancer Subtypes and Therapies b. Molecular Subsystems i. Introduction ii. Construction iii. Interpretation iv. Validation c. Summary VII. Prostaglandin dehydrogenase signaling 32 One driver and an unknown path a. Introduction i. Colon Cancer ii. Mass spectrometry 3 b. Methods c. Results d. Discussion e. Summary VIII. Apc signaling with Candidate Drivers 71 Two drivers, many paths a. Introduction b. Methods c. Results and Discussion d. Summary IX. Apc-Cdkn1a signaling 87 Two drivers, one path a. Introduction b. Methods c. Results i. Driver Gene Network Prediction ii. Single Node Perturbations 1. mRNA profiling 2. Proteomic profiling d. Discussion e. Summary X. Molecular Subsystems in Cancer 114 The Present to the Future XI. Appendix I 119 Prostaglandin dehydrogenase associated data XII.
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Secretomic Profiling of Cells from Hollow Fiber Bioreactor Reveals PSMA3 As a Potential Cholangiocarcinoma Biomarker
INTERNATIONAL JOURNAL OF ONCOLOGY Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker CHRIS VERATHAMJAMRAS1, CHURAT WEERAPHAN1,2, DARANEE CHOKCHAICHAMNANKIT1, KAMOLWAN WATCHARATANYATIP1, PANTIPA SUBHASITANONT1, PENCHATR DISKUL-NA-AYUDTHAYA1, KANOKWAN MINGKWAN3, VIRAT LUEVISADPAIBUL4, SOMCHAI CHUTIPONGTANATE5, VORARATT CHAMPATTANACHAI1, JISNUSON SVASTI1,6 and CHANTRAGAN SRISOMSAP1 1Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210; 2Department of Molecular Biotechnology and Bioinformatics, Faculty of Science, Prince of Songkla University, Songkla 90110; 3Department of Surgery, Sappasitthiprasong Hospital; 4Division of Information and Technology, Ubonrak Thonburi Hospital, Ubon Ratchathani 34000; 5Pediatric Translational Research Unit, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400; 6Applied Biological Sciences Program, Chulabhorn Graduate Institute, Bangkok 10210, Thailand Received March 20, 2017; Accepted May 5, 2017 DOI: 10.3892/ijo.2017.4024 Abstract. Cholangiocarcinoma (CCA), derived from the bile higher than that in MNC conditioned media. Three types of duct, occurs with a relatively high incidence in Northeast proteasome subunit were also validated by immunoblotting Thailand. Early diagnosis is still hampered by the lack of and showed higher expression in the HFB system compared to sufficient biomarkers. In recent years, biomarker discovery MNC system. Proteasome subunit α type-3 (PSMA3)
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Oliver Stewart (150263067) and Luke Gaughan Ph.D Upon Tyne, Tyne and Wear, UK Due to the Decreased Relative Expression of PSA in All but One of the Conditions
PSMA4 and PSMA6 of the 20S Proteasome and their roles in Androgen Receptor signalling in Prostate Cancer Discussion Northern Institute for Cancer Research, Newcastle University, NE2 4HH, Newcastle PSMA4 and PSMA6 knockdown proved to be successful By Oliver Stewart (150263067) and Luke Gaughan Ph.D upon Tyne, Tyne and Wear, UK due to the decreased relative expression of PSA in all but one of the conditions. Western Blot analysis also reinforces the successive knockdown of the proteasome subunits. Introduction Hypothesis, Aims and Objectives Results and Conclusions Conversely, PCR analysis for the PSMA4 KD –ENZ group Background Hypothesis: shows a higher relative expression of PSA than the Scr 1. Knockdown of proteasome subunits (control) group. This anomaly can be explained by the PSMA4 and PSMA6 compromises fact that only one reading of PSA expression was taken. In the UK 2014, prostate cancer was found to be the transcriptional activity of PSA second most common cancer overall, with the disease Gene knockdown of PSMA4 and PSMA6 To improve on this, I would take multiple readings for the being the most common cancer in males. Fortunately, decreases AR signalling and subsequently relative expression of PSA, allowing the calculation of an prostate cancer is very treatable, with an 84% survival reduces the expression of AREs in CW22Rv1 accurate average, thus, removing any anomalous data. rate for 10 or more years between 2010-2011 in England cells. Consequently, a conclusion regarding the individual and Wales. effectiveness of either a PSMA4 or PSMA6 knockdown on reducing ARE transcriptional activity could not be made. Aims and Objectives: However, individual patients can fail to respond to treatments, including: androgen depletion therapy, Moreover, the absence or presence of Enzalutamide antiandrogens (such as Enzalutamide (ENZ)) or • To investigate the functions of PSMA4 and seemed to show no effect on the transcriptional activity orchidectomy which can result in castration-resistant PSMA6 in AR signalling of PSA.
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PSMA6 (Rs2277460, Rs1048990), PSMC6 (Rs2295826, Rs2295827) and PSMA3 (Rs2348071) Genetic Diversity in Latvians, Lithuanians and Taiwanese
Meta Gene 2 (2014) 283–298 Contents lists available at ScienceDirect Meta Gene PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese Tatjana Sjakste a,⁎, Natalia Paramonova a, Lawrence Shi-Shin Wu b, Zivile Zemeckiene c, Brigita Sitkauskiene d, Raimundas Sakalauskas d, Jiu-Yao Wang e, Nikolajs Sjakste f,g a Genomics and Bioinformatics, Institute of Biology of the University of Latvia, Miera str. 3, LV2169, Salaspils, Latvia b Institute of Biomedicine, Tzu-Chi University, Tzu-Chi, Taiwan c Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania d Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania e Division of Allergy and Clinical Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan f Faculty of Medicine, University of Latvia, Riga, Latvia g Latvian Institute of Organic Synthesis, Riga, Latvia article info abstract Article history: PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and Received 26 February 2014 PSMA3 (rs2348071) genetic diversity was investigated in 1438 Revised 11 March 2014 unrelated subjects from Latvia, Lithuania and Taiwan. In general, Accepted 17 March 2014 polymorphism of each individual locus showed tendencies similar to Available online xxxx determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found Keywords: before in Asians and absence of rs2295827 rare alleles homozygotes TT PSMA3 PSMA6 observed in all other human populations.ObservedpatternsofSNPsand PSMC6 haplotype diversity were compatible with expectation of neutral model of Proteasome evolution. Linkage disequilibrium between the rs2295826 and rs2295827 SNP was detected to be complete in Latvians and Lithuanians (DV=1;r2 =1) Genetic diversity and slightly disrupted in Taiwanese (DV= 0.978; r2 =0.901).
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