Surgical Anatomy, Embryology, and Physiology of the Salivary Glands John D
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k Chapter 1 Surgical Anatomy, Embryology, and Physiology of the Salivary Glands John D. Langdon, FKC, MB BS, BDS, MDS, FDSRCS, FRCS, FMedSci King’s College, London, UK Outline Summary References Introduction The Parotid Gland Embryology Introduction Anatomy Contents of the Parotid Gland There are three pairs of major salivary glands The Facial Nerve consisting of the parotid, submandibular, and Auriculotemporal Nerve sublingual glands. In addition, there are numerous Retromandibular Vein minor glands distributed throughout the oral cavity External Carotid Artery within the mucosa and submucosa. Parotid Lymph Nodes k On average, about 0.5 liters of saliva are pro- k Parotid Duct duced each day but the rate varies throughout the Nerve Supply to the Parotid day. At rest, about 0.3 ml/min are produced but this The Submandibular Gland rises to 2.0 ml/min with stimulation. The contribu- Embryology Anatomy tion from each gland also varies. At rest, the parotid The Superficial Lobe produces 20%, the submandibular gland 65%, and The Deep Lobe the sublingual and minor glands 15%. On stimula- The Submandibular Duct tion, the parotid secretion rises to 50%. The nature Blood Supply and Lymphatic Drainage of the secretion also varies from gland to gland. Nerve Supply to the Submandibular Gland Parotid secretions are almost exclusively serous, the Parasympathetic Innervation submandibular secretions are mixed and the sublin- Sympathetic Innervation gual and minor gland secretions are predominantly Sensory Innervation mucinous. The Sublingual Gland Saliva is essential for mucosal lubrication, Embryology speech, and swallowing. It also performs an essen- Anatomy tial buffering role that influences demineralization Sublingual Ducts of teeth as part of the carious process. When Blood Supply, Innervation, and Lymphatic Drainage there is a marked deficiency in saliva produc- Minor Salivary Glands tion, xerostomia, rampant caries, and destructive Histology of the Salivary Glands periodontal disease ensues. Various digestive Control of Salivation enzymes – salivary amylase – and antimicrobial Salivary Gland Pathology: Diagnosis and Management, Second Edition. Edited by Eric R. Carlson and Robert A. Ord. © 2016 John Wiley & Sons, Inc. Published 2016 by John Wiley & Sons, Inc. 1 k k 2 Chapter 1 agents – IgA, lysozyme, and lactoferrin – are also exocrine gland. In the adult, the gland is composed secreted with the saliva. entirely of serous acini. The gland is situated in the space between the posterior border of the mandibular ramus and the The Parotid Gland mastoid process of the temporal bone. The exter- nal acoustic meatus and the glenoid fossa lie above EMBRYOLOGY together with the zygomatic process of the tempo- ral bone (Figure 1.1). On its deep (medial) aspect The parotid gland develops as a thickening of the lies the styloid process of the temporal bone. Infe- epithelium in the cheek of the oral cavity in the riorly, the parotid frequently overlaps the angle of 15 mm Crown Rump length embryo. This thicken- the mandible and its deep surface overlies the trans- ing extends backwards towards the ear in a plane verse process of the atlas vertebra. superficial to the developing facial nerve. The deep The shape of the parotid gland is variable. aspect of the developing parotid gland produces Often it is triangular with the apex directed inferi- bud like projections between the branches of the orly. However, on occasion it is more or less of even facial nerve in the third month of intra-uterine life. width and occasionally it is triangular with the These projections then merge to form the deep apex superiorly. On average, the gland is 6 cm in lobe of the parotid gland. By the sixth month of length with a maximum of 3.3 cm in width. In 20% intra-uterine life the gland is completely canalized. of subjects a smaller accessory lobe arises from Although not embryologically a bilobed structure, the upper border of the parotid duct approximately the parotid comes to form a larger (80%) superfi- 6 mm in front of the main gland. This accessory cial lobe and a smaller (20%) deep lobe joined by lobe overlies the zygomatic arch. an isthmus between the two major divisions of the The gland is surrounded by a fibrous capsule facial nerve. The branches of the nerve lie between previously thought to be formed from the investing layer of deep cervical fascia. This fascia passes these lobes invested in loose connective tissue. k up from the neck and was thought to split to k This observation is vital in the understanding of enclose the gland. The deep layer is attached to the the anatomy of the facial nerve and surgery in this mandible and the temporal bone at the tympanic region (Berkovitz, et al. 2003). plate and styloid and mastoid processes (McMinn, et al. 1984; Berkovitz and Moxham 1988; Williams ANATOMY 1995; Ellis 1997). Recent investigations suggest that the superficial layer of the parotid capsule is Theparotidisthelargestofthemajorsalivary not formed in this way, but is part of the superficial glands. It is a compound, tubuloacinar, merocrine, musculo-aponeurotic system (SMAS) (Mitz and Figure 1.1. A lateral view of the skull showing some of the bony features related to the bed of the parotid gland. 1: Mandibular fossa; 1 2 2: Articular eminence; 3: Tympanic 9 4 plate; 4: Mandibular condyle; 5: Styloid process; 6: Ramus of 3 8 mandible; 7: Angle of mandible; 6 5 8: Mastoid process; 9: External acoustic meatus. Source: Surgical Management of the Infratemporal 7 Fossa. (J. Langdon, B. Berkovitz & B. Moxham). ISBN 9781899066797. Reproduced with permission of Taylor & Francis Books UK. k k Surgical Anatomy, Embryology, and Physiology of the Salivary Glands 3 Peyronie 1976; Jost and Levet 1983; Wassef 1987; and the parotid duct lie within a loose cellular Thaller, et al. 1989; Zigiotti, et al. 1991; Gosain, layer between these two sheets of fascia. This et al. 1993; Flatau and Mills 1995). Anteriorly, observation is important in parotid surgery. When the superficial layer of the parotid capsule is thick operating on the parotid gland, the skin flap can and fibrous but more posteriorly, it becomes a either be raised in the subcutaneous fat layer or thin translucent membrane. Within this fascia are deep to the SMAS layer. The SMAS layer itself can scant muscle fibers running parallel with those of be mobilized as a separate flap and can be used to the platysma. This superficial layer of the parotid mask the cosmetic defect following parotidectomy capsule appears to be continuous with the fascia by reattaching it firmly to the anterior border of the overlying the platysma muscle. Anteriorly, it forms sternocleidomastoid muscle as an advancement a separate layer overlying the masseteric fascia, flap (Meningaud, et al. 2006). which is itself an extension of the deep cervical The superior border of the parotid gland fascia. The peripheral branches of the facial nerve (usually the base of the triangle) is closely molded 1 k k 2 2 3 Figure 1.2. The parotid gland and 4 associated structures. 1: Auriculotem- poralnerve;2:Superficialtemporal 8 vessels; 3: Temporal branch of facial nerve; 4: Zygomatic branch of facial 9 nerve; 5: Buccal branch of facial nerve; 5 6: Mandibular branch of facial nerve; 10 7: Cervical branch of facial nerve; 8: Parotid duct; 9: Parotid gland; 10: Mas- 6 seter muscle; 11: Facial vessels; 12: 11 Platysma muscle; 13: External jugular 11 vein; 14: Sternocleidomastoid muscle; 15 15: Great auricular nerve. Source: Sur- 14 gical Management of the Infratempo- 7 12 13 ral Fossa. (J. Langdon, B. Berkovitz & B. Moxham). ISBN 9781899066797. Reproduced with permission of Taylor & Francis Books UK. k k 4 Chapter 1 around the external acoustic meatus and the tem- poromandibular joint. An avascular plane exists Lateral pterygoid muscle between the gland capsule and the cartilaginous Medial pterygoid and bony acoustic meatus (Figure 1.2). The infe- muscle Superior pharyngeal rior border (usually the apex) is at the angle of constrictor muscle the mandible and often extends beyond this to overlap the digastric triangle where it may lie very close to the posterior pole of the submandibular Stylopharyngeus muscle salivary gland. The anterior border just overlaps the posterior border of the masseter muscle and Styloid process the posterior border overlaps the anterior border Middle pharyngeal Stylomandibular constrictor muscle of the sternocleidomastoid muscle. ligament The superficial surface of the gland is cov- Mandibulo-stylohyoid ered by skin and platysma muscle. Some terminal ligament Inferior pharyngeal constrictor muscle branches of the great auricular nerve also lie super- Masseter muscle Posterior border ficial to the gland. At the superior border of the of ramus parotid lie the superficial temporal vessels with the Facial vein and artery artery in front of the vein. The auriculotemporal Submandibular gland branch of the mandibular nerve runs at a deeper level just behind the superficial temporal vessels. The branches of the facial nerve emerge from the anterior border of the gland. The parotid duct also emerges to run horizontally across the Figure 1.3. The mandibulostylohyoid ligament and masseter muscle before piercing the buccinator surrounding anatomy. muscle anteriorly to end at the parotid papilla. The k transverse facial artery (a branch of the superficial k temporal artery) runs across the area parallel to the mandible. The mandibulostylohyoid ligament and approximately 1 cm above the parotid duct. (the angular tract) passes between the angle of the The anterior and posterior branches of the facial mandible and the stylohyoid ligament. Inferiorly, vein emerge from the inferior border. it usually extends down to the hyoid bone. These The deep (medial) surface of the parotid ligaments are all that separates the parotid gland gland lies on those structures forming the parotid anteriorly from the posterior pole of the superficial bed. Anteriorly, the gland lies over the masseter lobe of the submandibular gland.