bioRxiv preprint doi: https://doi.org/10.1101/397554; this version posted August 22, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion Running Title: Lin et al.; A1CF in Triglyceride Metabolism Jennie Lin,1,2* Donna M. Conlon,3* Xiao Wang,4* Eric Van Nostrand,5 Ines Rabano, 5 YoSon Park,6 Alanna Strong,7 Behram Radmanesh,1 Yoseph Barash,6 Daniel J. Rader,3,6,7 Gene W. Yeo,5 and Kiran Musunuru4,6 1Division of Nephrology and Hypertension and 2Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA 3Division of Translational Medicine and Human Genetics of the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA 4Cardiovascular Institute of the Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA 5Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA 6Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA 7Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA *These authors contributed equally. Address correspondence to: Jennie Lin, 303 East Superior Street, Lurie 10-109, Chicago, IL 60611 USA. Phone: 312-503-1892; Fax: 312-503-0137; E-mail:
[email protected] Kiran Musunuru, Smilow Center for Translational Research, Room 11-102, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.