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Roitt's Essential Immunology Peter J. Delves Roitt’s Essential Immunology Peter J. Delves Professor Delves obtained his PhD from the University of London in 1986 and is a Professor of Immunology at UCL (University College London). His research has focused on molecular aspects of antigen recognition. He has authored and edited a number of immunology books, and teaches the subject at a broad range of levels. Seamus J. Martin Professor Martin received his PhD from Th e National University of Ireland in 1990 and trained as a post - doctoral fellow at University College London (with Ivan Roitt) and Th e La Jolla Institute for Allergy and Immunology, California, USA (with Doug Green). Since 1999, he is the holder of the Smurfi t Chair of Medical Genetics at Trinity College Dublin and is also a Science Foundation Ireland Principal Investigator. His research is focused on various aspects of programmed cell death (apoptosis) in the immune system and in cancer and he has received several awards for his work in this area. He has previously edited two books on apoptosis and was elected as a Member of Th e Royal Irish Academy in 2006 and as a member of Th e European Molecular Biology Organisation (EMBO) in 2009. Dennis R. Burton Professor Burton obtained his BA in Chemistry from the University of Oxford in 1974 and his PhD in Physical Biochemistry from the University of Lund in Sweden in 1978. After a period at the University of Sheffi eld, he moved to the Scripps Research Institute in La Jolla, California in 1989 where he is Professor of Immunology and Molecular Biology. His research interests include antibodies, antibody responses to pathogens and vaccine design, particularly in relation to HIV. Ivan M. Roitt Professor Roitt was born in 1927 and educated at King Edward ’ s School, Birmingham and Balliol College, Oxford. In 1956, together with Deborah Doniach and Peter Campbell, he made the classic discovery of thyroglobulin autoantibodies in Hashimoto ’ s thyroiditis which helped to open the whole concept of a relationship between autoimmunity and human disease. Th e work was extended to an intensive study of autoimmune phenomena in pernicious anaemia and primary biliary cirrhosis. In 1983 he was elected a Fellow of Th e Royal Society, and has been elected to Honorary Membership of the Royal College of Physicians and appointed Honorary Fellow of Th e Royal Society of Medicine. TWELFTH EDITION Roitt’s Essential Immunology Peter J. Delves PhD Division of Infection and Immunity UCL London, UK Seamus J. Martin PhD, FTCD, MRIA Th e Smurfi t Institute of Genetics Trinity College Dublin, Ireland Dennis R. Burton PhD Department of Immunology and Molecular Biology Th e Scripps Research Institute La Jolla, California, USA Ivan M. Roitt MA, DSc(Oxon), FRCPath, Hon FRCP (Lond), FRS Centre for Investigative and Diagnostic Oncology Middlesex University London, UK A John Wiley & Sons, Ltd., Publication Th is edition fi rst published 2011 © 1971, 1974, 1977, 1980, 1984, 1988, 1991, 1994, 1997, 2001, 2006 by Peter J Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientifi c, Technical and Medical business to form Wiley-Blackwell. Registered offi ce: John Wiley & Sons, Ltd, Th e Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offi ces: 9600 Garsington Road, Oxford, OX4 2DQ, UK Th e Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offi ces, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell Th e right of the author to be identifi ed as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. Th e publisher is not associated with any product or vendor mentioned in this book. Th is publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought. Th e contents of this work are intended to further general scientifi c research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting a specifi c method, diagnosis, or treatment by physicians for any particular patient. Th e publisher and the author make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifi cally disclaim all warranties, including without limitation any implied warranties of fi tness for a particular purpose. In view of ongoing research, equipment modifi cations, changes in governmental regulations, and the constant fl ow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist where appropriate. Th e fact that an organization or Website is referred to in this work as a citation and/or a potential source of further information does not mean that the author or the publisher endorses the information the organization or Website may provide or recommendations it may make. Further, readers should be aware that Internet Websites listed in this work may have changed or disappeared between when this work was written and when it is read. No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom. Library of Congress Cataloging-in-Publication Data Roitt’s essential immunology / Peter J. Delves ... [et al.]. – 12th ed. p. cm. – (Essentials ; 16) Rev. ed. of: Roitt’s essential immunology / Ivan M. Roitt, Peter J. Delves. Includes bibliographical references and index. ISBN 978-1-4051-9683-3 (pbk.) 1. Immunology. I. Delves, Peter J. II. Roitt, Ivan M. (Ivan Maurice) Roitt’s essential immunology. III. Title: Essential immunology. QR181.R57 2011 616.07'9–dc22 2010047392 A catalogue record for this book is available from the British Library. Set in 10/12 pt Adobe Garamond Pro by Toppan Best-set Premedia Limited 1 2011 Contents Acknowledgments vi Preface vii Abbreviations viii How to get the best out of your textbook xii PART 1: Fundamentals of Immunology 1. Innate immunity 3 2. Specifi c acquired immunity 35 3. Antibodies 53 4. Membrane receptors for antigen 79 5. The primary interaction with antigen 113 6. Immunological methods and applications 141 7. The anatomy of the immune response 188 8. Lymphocyte activation 205 9. The production of effectors 226 10. Control mechanisms 263 11. Ontogeny and phylogeny 283 PART 2: Applied Immunology 12. Adversarial strategies during infection 313 13. Vaccines 345 14. Immunodefi ciency 369 15. Allergy and other hypersensitivities 394 16. Transplantation 423 17. Tumor immunology 445 18. Autoimmune diseases 475 Glossary 511 Index 522 Companion website www.roitt.com Acknowledgments Th e input of the editorial team of Elizabeth Johnston, Laura Murphy and Cathryn Gates at Wiley - Blackwell and the project management of Ruth Swan is warmly acknowledged. We are much indebted to the co - editors of Immunology, J. Brostoff , D. Roth and D. Male, together with the publishers, Mosby, and the following individuals for permission to utilize or modify their fi gures: J. Brostoff and A. Hall for fi gure 15.11 ; J. Horton for fi gure 11.19 ; and J. Taverne for fi gures 12.23 and 12.24 . IMR would like to acknowledge the indefatigable secretarial assistance of Christine Griffi n. DRB wishes to particularly acknowledge the invaluable contributions of Amandeep Gakhal, Erin Scherer, Rena Astronomo and Wendelien Oswald. He is grateful to Jenny Woof, Ann Feeney, Beatrice Hahn, Jim Marks, Don Mosier, Paul Sharp, Robyn Stanfi eld, James Stevens and Mario Stevenson for many very helpful comments. PJD would particularly like to thank Per Brandtzaeg, Volker Brinkmann, Greg Campbell, Peter Lydyard, Rand Swenson and Ulrich Wahn. SJM is indebted to Ed Lavelle, Sean Cullen, Cristina Munoz - Pinedo and all of the members of his laboratory for comments, suggestions and support. He would also like to thank Mia, Madeleine and Jamie for their support and indulgence. Every eff ort has been made by the authors and the publisher to contact all the copyright holders to obtain their permission to reproduce copyright material. However, if any have been inadvertently overlooked, the publisher will be pleased to make the necessary arrangements at the
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