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Lung Transplantation with the OCS (Organ Care System)
Lung Transplantation with the OCSTM (Organ Care System) Lung System Bringing Breathing Lung Preservation to Transplant Patients A Guide for You and Your Family DRAFT ABOUT THIS BOOKLET This booklet was created for patients like you who have been diagnosed with end-stage lung failure and are candidates for a lung transplant. It contains information that will help you and your family learn about options available to you for a transplant. This booklet includes information on your lungs, how they function, and respiratory failure. In addition, you will learn about a new way to preserve lungs before transplantation, called breathing lung preservation. Your doctor is the best person to explain your treatment options and their risks and to help you decide which option is right for you. The booklet explains: • Breathing lung preservation with the OCS™ Lung System • How the OCS™ Lung System works • Who is eligible for the OCS™ Lung System • Lung transplant complications • How the lungs function • What is respiratory failure and the treatment options • What to expect during your treatment • Summary of clinical data for the OCS™ Lung System • Contact Information Please read this booklet carefully and share it with your family and caregivers. For your convenience, a glossary is provided in the front of this booklet. Terms in the text in bold italics are explained in the glossary. If you have questions about the OCS™ Lung System that are not answered in this booklet, please ask your physician. This booklet is intended for general information only. It is not intended to tell you everything you need to know about a lung transplant. -
Anatomy and Physiology
Anatomy and Physiology By Dr. Marwan Arbilei SYSTEMS INSIDE THE BODY What Is Anatomy and Physiology? • Skeletal system • Muscular system • Anatomy is the study of the • Cardiovascular system structure and relationship • Digestive system between body parts. • Endocrine system • Nervous system • Physiology is the study of the • Respiratory system function of body parts and • Immune/ Lymphatic system the body as a whole. • Urinary system • Male and Female Reproductive system • Integumentary system Skeletal system The axial skeleton runs along the body’s midline axis and is made up of 80 bones in the following regions: Skull Hyoid Auditory ossicles Ribs Sternum Vertebral column The appendicular skeleton is made up of 126 bones in the following regions: Upper limbs Lower limbs Pelvic girdle Pectoral (shoulder) girdle Joints Fibrous Joint -non movable. eg: skull Cartilaginous Joint –chest bone, vertebrae Synovial Joint – elbow,knee,hip,shoulder,finger Vertebral column • Vertebral column • Total 33 vertebrae • Cervical 7 • Thoracic 12 • Lumber 5 • Sacral 5 • Coccygeial 4 Muscular system There are three types of muscle tissue: Visceral Stomach, intestines, blood vessels Cardiac Heart Skeletal Muscles attached to two bones across a joint Cardiovascular system Anatomy • The Heart • Circulatory Loops Functions • Blood Vessels Transportation • Coronary Circulation Protection • Hepatic Portal Circulation Regulation • Blood Digestive system Anatomy Mouth-Pharynx – Esophagus – Stomach - Small Intestine - Liver and Gallbladder – Pancreas -
Gross Anatomy Assignment Name: Olorunfemi Peace Toluwalase Matric No: 17/Mhs01/257 Dept: Mbbs Course: Gross Anatomy of Head and Neck
GROSS ANATOMY ASSIGNMENT NAME: OLORUNFEMI PEACE TOLUWALASE MATRIC NO: 17/MHS01/257 DEPT: MBBS COURSE: GROSS ANATOMY OF HEAD AND NECK QUESTION 1 Write an essay on the carvernous sinus. The cavernous sinuses are one of several drainage pathways for the brain that sits in the middle. In addition to receiving venous drainage from the brain, it also receives tributaries from parts of the face. STRUCTURE ➢ The cavernous sinuses are 1 cm wide cavities that extend a distance of 2 cm from the most posterior aspect of the orbit to the petrous part of the temporal bone. ➢ They are bilaterally paired collections of venous plexuses that sit on either side of the sphenoid bone. ➢ Although they are not truly trabeculated cavities like the corpora cavernosa of the penis, the numerous plexuses, however, give the cavities their characteristic sponge-like appearance. ➢ The cavernous sinus is roofed by an inner layer of dura matter that continues with the diaphragma sellae that covers the superior part of the pituitary gland. The roof of the sinus also has several other attachments. ➢ Anteriorly, it attaches to the anterior and middle clinoid processes, posteriorly it attaches to the tentorium (at its attachment to the posterior clinoid process). Part of the periosteum of the greater wing of the sphenoid bone forms the floor of the sinus. ➢ The body of the sphenoid acts as the medial wall of the sinus while the lateral wall is formed from the visceral part of the dura mater. CONTENTS The cavernous sinus contains the internal carotid artery and several cranial nerves. Abducens nerve (CN VI) traverses the sinus lateral to the internal carotid artery. -
Case Report AJNT
Arab Journal of Nephrology and Transplantation. 2011 Sep;4(3):155-8 Case Report AJNT High Ureteric Injury Following Multiorgan Recovery: Successful Kidney Transplant with Boari Flap Ureterocystostomy Reconstruction Michael Charlesworth*, Gabriele Marangoni, Niaz Ahmad Department of Transplantation, Division of Surgery, St James’s University Hospital, Leeds, United Kingdom Abstract Keywords: Kidney; Transplant; Ureter; Donor efficiency Introduction: Despite increased utilization of marginal organs, there is still a marked disparity between organ The authors declared no conflict of interest supply and demand for transplantation. To maximize resources, it is imperative that procured organs are in Introduction good condition. Surgical damage at organ recovery can happen and organs are sometimes discarded as a result. Despite the extension of the donor pool with the inclusion We describe a damaged recovered kidney with high of marginal organs and the use of organs donated after ureteric transection that was successfully transplanted cardiac death, there is still a great disparity between the using a primary Boari flap ureterocystostomy. number of patients on the transplant waiting list and the number of kidney transplants performed each year. Case report: The donor kidney was procured form a It is therefore of paramount importance to maximize deceased donor and sustained damage by transection our scarce resources and avoid the discard of otherwise of the ureter just distal to the pelvi-ureteric junction at functional kidneys due to iatrogenic injuries at the time organ recovery. The recipient had been on the transplant of multi-organ recovery. Essentially, three types of organ waiting list for eight years and not accepting this kidney damage can potentially occur: vascular, parenchymal would have seriously jeopardized her chance of future and ureteric. -
Human Physiology/The Male Reproductive System 1 Human Physiology/The Male Reproductive System
Human Physiology/The male reproductive system 1 Human Physiology/The male reproductive system ← The endocrine system — Human Physiology — The female reproductive system → Homeostasis — Cells — Integumentary — Nervous — Senses — Muscular — Blood — Cardiovascular — Immune — Urinary — Respiratory — Gastrointestinal — Nutrition — Endocrine — Reproduction (male) — Reproduction (female) — Pregnancy — Genetics — Development — Answers Introduction In simple terms, reproduction is the process by which organisms create descendants. This miracle is a characteristic that all living things have in common and sets them apart from nonliving things. But even though the reproductive system is essential to keeping a species alive, it is not essential to keeping an individual alive. In human reproduction, two kinds of sex cells or gametes are involved. Sperm, the male gamete, and an egg or ovum, the female gamete must meet in the female reproductive system to create a new individual. For reproduction to occur, both the female and male reproductive systems are essential. While both the female and male reproductive systems are involved with producing, nourishing and transporting either the egg or sperm, they are different in shape and structure. The male has reproductive organs, or genitals, that are both inside and outside the pelvis, while the female has reproductive organs entirely within the pelvis. The male reproductive system consists of the testes and a series of ducts and glands. Sperm are produced in the testes and are transported through the reproductive ducts. These ducts include the epididymis, ductus deferens, ejaculatory duct and urethra. The reproductive glands produce secretions that become part of semen, the fluid that is ejaculated from the urethra. These glands include the seminal vesicles, prostate gland, and bulbourethral glands. -
Pelvic Anatomyanatomy
PelvicPelvic AnatomyAnatomy RobertRobert E.E. Gutman,Gutman, MDMD ObjectivesObjectives UnderstandUnderstand pelvicpelvic anatomyanatomy Organs and structures of the female pelvis Vascular Supply Neurologic supply Pelvic and retroperitoneal contents and spaces Bony structures Connective tissue (fascia, ligaments) Pelvic floor and abdominal musculature DescribeDescribe functionalfunctional anatomyanatomy andand relevantrelevant pathophysiologypathophysiology Pelvic support Urinary continence Fecal continence AbdominalAbdominal WallWall RectusRectus FasciaFascia LayersLayers WhatWhat areare thethe layerslayers ofof thethe rectusrectus fasciafascia AboveAbove thethe arcuatearcuate line?line? BelowBelow thethe arcuatearcuate line?line? MedianMedial umbilicalumbilical fold Lateralligaments umbilical & folds folds BonyBony AnatomyAnatomy andand LigamentsLigaments BonyBony PelvisPelvis TheThe bonybony pelvispelvis isis comprisedcomprised ofof 22 innominateinnominate bones,bones, thethe sacrum,sacrum, andand thethe coccyx.coccyx. WhatWhat 33 piecespieces fusefuse toto makemake thethe InnominateInnominate bone?bone? PubisPubis IschiumIschium IliumIlium ClinicalClinical PelvimetryPelvimetry WhichWhich measurementsmeasurements thatthat cancan bebe mademade onon exam?exam? InletInlet DiagonalDiagonal ConjugateConjugate MidplaneMidplane InterspinousInterspinous diameterdiameter OutletOutlet TransverseTransverse diameterdiameter ((intertuberousintertuberous)) andand APAP diameterdiameter ((symphysissymphysis toto coccyx)coccyx) -
Õ“°“√§—¥®¡Ÿ° (Nasal Obstruction)
π“π“ “√– § ≈‘ π‘ ° Õ“°“√§—¥®¡Ÿ° (Nasal Obstruction) Õ“°“√§¥®¡— °Ÿ (Nasal Obstruction) Õ“°“√§—¥®¡Ÿ°‡ªìπÕ“°“√∑’Ëæ∫‰¥â∫àÕ¬„π‡«™ªØ‘∫—µ‘ ´÷ËßÕ“®‡ªìπÕ“°“√∑’Ëæ∫‰¥âµ“¡ª°µ‘ (´÷Ëßæ∫‡ªìπ à«ππâÕ¬ ‰¥â·°à Õ“°“√§—¥®¡Ÿ°∑’ˇ°‘¥®“°°“√∑’Ë®¡Ÿ°∑”ß“π ≈—∫¢â“ß°—πµ“¡∏√√¡™“µ‘ ∑’ˇ√’¬°«à“ nasal À√◊Õ turbinate cycle À√◊ÕÕ“°“√§—¥®¡Ÿ°∑’ˇ°‘¥®“°°“√‡ª≈’ˬπ∑à“∑“ß ‡™àπ πÕπµ–·§ß·≈â«§—¥®¡Ÿ°¢â“ß∑’ËπÕπ∑—∫Õ¬Ÿà ‡¡◊ËÕµ–·§ß‰ªÕ’°¥â“πÀπ÷Ëß ¥â“π∑’ˇ§¬§—¥®–°≈—∫‚≈àߢ÷Èπ ´÷Ë߇°‘¥®“°·√ߥ÷ߥŸ¥¢Õß‚≈°) À√◊Õ‡°‘¥®“°‚√§¢Õß®¡Ÿ°À≈“¬Ê ™π‘¥ (´÷Ëßæ∫‡ªìπ à«π¡“°) ·≈– ‡ªìπÕ“°“√∑’Ëæ∫∫àÕ¬Õ’°Õ“°“√Àπ÷Ëß∑’Ëπ”ºŸâªÉ«¬¡“À“·æ∑¬å ‡π◊ËÕß®“°¡—°∑”„À⺟âªÉ«¬√”§“≠ ·≈– ∑π∑ÿ°¢å∑√¡“π ·≈–¡’§ÿ≥¿“æ™’«‘µ·¬à≈ß „πª√–‡∑» À√—∞Õ‡¡√‘°“‰¥â‡§¬¡’ºŸâª√–‡¡‘π«à“¡’§à“„™â ®à“¬„π°“√√—°…“Õ“°“√§—¥®¡Ÿ° Ÿß∂÷ß 5 æ—π≈â“π‡À√’¬≠ À√—∞µàÕªï ·≈–¡’§à“„™â®à“¬ Ÿß∂÷ß 60 ≈â“π ‡À√’¬≠ À√—∞µàÕªï „π°“√∑”°“√ºà“µ—¥√—°…“Õ“°“√§—¥®¡Ÿ°1. §”®”°¥§«“¡— Õ“°“√§¥®¡— °‡ªŸ πÕ“°“√∑ì º’Ë ªŸâ «¬√É Ÿâ °À√÷ Õ‡¢◊ “„®«â “≈¡À√à ÕÕ“°“»∑◊ º’Ë “π‡¢à “À√â ÕÕÕ°®“°®¡◊ °Ÿ πâÕ¬°«à“ª°µ‘ ‚¥¬∑’Ë¡’≈¡À√◊ÕÕ“°“»∑’˺à“π‡¢â“À√◊ÕÕÕ°®“°®¡Ÿ°πâÕ¬®√‘ß (objective restriction of nasal cavity airflow) ‡π◊ËÕß®“°¡’§«“¡º‘¥ª°µ‘¢Õ߇¬◊ËÕ∫ÿ®¡Ÿ° À√◊Õ¡’ª√‘¡“≥πÈ”¡Ÿ°‡æ‘Ë¡¡“° ¢÷Èπ2 °“√∑’ˇ¬◊ËÕ∫ÿ®¡Ÿ° “¡“√∂√—∫√ŸâÕ“°“»∑’˺à“π‡¢â“À√◊ÕÕÕ°®“°®¡Ÿ° ‡™◊ËÕ«à“ºà“π∑“ßµ—«√—∫√Ÿâ —¡º— ·≈–Õÿ≥À¿Ÿ¡‘ (tactile and thermoreceptors) ∑’ËÕ¬Ÿà„π nasal vestibule ·≈–‡¬◊ËÕ∫ÿ®¡Ÿ° ´÷Ëß §«“¡‰«¢Õßµ—«√—∫√Ÿâ¥—ß°≈à“«®–πâÕ¬≈߇√◊ËÕ¬Ê ®“°¥â“πÀπⓉª¥â“πÀ≈—ß ‡ âπª√– “∑∑’Ë√—∫√ŸâÕ“°“» ª“√¬– Õ“»π–‡ π æ.∫., √Õß»“ µ√“®“√¬ å “¢“‚√§®¡°·≈–‚√§¿Ÿ ¡Ÿ ·æ‘ â ¿“§«™“‚ µ‘ π“ °‘ ≈“√ß´‘ «å ∑¬“‘ §≥–·æ∑¬»“ µ√»å √‘ √“™æ¬“∫“≈‘ ¡À“«∑¬“≈‘ ¬¡À— ¥≈‘ §≈‘π‘° ªï∑’Ë 29 ©∫—∫∑’Ë 4 ‡¡…“¬π 2556 235 ∑’˺à“π‡¢â“À√◊ÕÕÕ°®“°®¡Ÿ° §◊Õ ª√– “∑ ¡Õß§Ÿà∑’Ë 5 Õ“°“»„ÀâÕÿàπ·≈–™◊Èπ¢÷ÈππâÕ¬°«à“§πª°µ‘, ºŸâªÉ«¬‚√§ (ophthalmic and maxillary branch of trigeminal ®¡Ÿ°Õ—°‡ ∫¿Ÿ¡‘·æâ™π‘¥ƒ¥Ÿ°“≈∑’ËÕ¬ŸàπÕ°ƒ¥Ÿ°“≈À√◊Õ nerve). -
Dorsal Approach Rhinoplasty Dorsal Approach Rhinoplasty
AIJOC 10.5005/jp-journals-10003-1105 ORIGINAL ARTICLE Dorsal Approach Rhinoplasty Dorsal Approach Rhinoplasty Kenneth R Dubeta Part I: Historical Milestones in Rhinoplasty ABSTRACT Direct dorsal excision of skin and subcutaneous tissue is employed in rhinoplasty cases characterized by thick rigid skin to achieve satisfactory esthetic results, in which attempted repair by more conventional means would most likely frustrate both surgeon and patient. This historical review reminds us of the lesson: ‘History repeats itself.’ Built on a foundation of reconstructive rhinoplasty, modern cosmetic and corrective rhinoplasty have seen the parallel development of both open and closed techniques as ‘new’ methods are introduced and reintroduced again. It is from the perspective of constant evolution in the art of rhinoplasty surgery that the author presents, in Part II, his unique ‘eagle wing’ chevron incision technique of dorsal approach rhinoplasty, to overcome the problems posed by the rigid skin nose. Keywords: Dorsal approach rhinoplasty, Eagle wing incision, Fig. 1: Ancient Greek ‘perikephalea’ to support the Rigid skin nose, External approach rhinoplasty, Historical straightened nose1 milestones. How to cite this article: Dubeta KR. Dorsal Approach and functions of the nose. Refinement of these techniques Rhinoplasty. Int J Otorhinolaryngol Clin 2013;5(1):1-23. seemingly had to await three antecedent developments; Source of support: Nil topical vasoconstriction; topical, systemic and local Conflict of interest: None declared anesthesia; and safe, reliable sources of illumination. The last half of the 20th century has seen the dissemination of INTRODUCTION two of the most important developments in the history of Throughout the ages, numerous techniques of altering, nasal surgery: correcting and more recently, improving the appearance and 1. -
Male Reproductive System
MALE REPRODUCTIVE SYSTEM DR RAJARSHI ASH M.B.B.S.(CAL); D.O.(EYE) ; M.D.-PGT(2ND YEAR) DEPARTMENT OF PHYSIOLOGY CALCUTTA NATIONAL MEDICAL COLLEGE PARTS OF MALE REPRODUCTIVE SYSTEM A. Gonads – Two ovoid testes present in scrotal sac, out side the abdominal cavity B. Accessory sex organs - epididymis, vas deferens, seminal vesicles, ejaculatory ducts, prostate gland and bulbo-urethral glands C. External genitalia – penis and scrotum ANATOMY OF MALE INTERNAL GENITALIA AND ACCESSORY SEX ORGANS SEMINIFEROUS TUBULE Two principal cell types in seminiferous tubule Sertoli cell Germ cell INTERACTION BETWEEN SERTOLI CELLS AND SPERM BLOOD- TESTIS BARRIER • Blood – testis barrier protects germ cells in seminiferous tubules from harmful elements in blood. • The blood- testis barrier prevents entry of antigenic substances from the developing germ cells into circulation. • High local concentration of androgen, inositol, glutamic acid, aspartic acid can be maintained in the lumen of seminiferous tubule without difficulty. • Blood- testis barrier maintains higher osmolality of luminal content of seminiferous tubules. FUNCTIONS OF SERTOLI CELLS 1.Germ cell development 2.Phagocytosis 3.Nourishment and growth of spermatids 4.Formation of tubular fluid 5.Support spermiation 6.FSH and testosterone sensitivity 7.Endocrine functions of sertoli cells i)Inhibin ii)Activin iii)Follistatin iv)MIS v)Estrogen 8.Sertoli cell secretes ‘Androgen binding protein’(ABP) and H-Y antigen. 9.Sertoli cell contributes formation of blood testis barrier. LEYDIG CELL • Leydig cells are present near the capillaries in the interstitial space between seminiferous tubules. • They are rich in mitochondria & endoplasmic reticulum. • Leydig cells secrete testosterone,DHEA & Androstenedione. • The activity of leydig cell is different in different phases of life. -
Science-5-Nov-16-20 Circulatory-System.Pdf
Grade 5 Science Week of November 16 – November 20 Circulatory System Most of the cells inside of your body do not move. If a cell is hungry or needs to get rid of waste, it can’t simply move itself to the part of your body where it needs to go. Instead, your body must bring the food to your cells and take the waste away from them. By using billions of tiny tubes the circulatory system transports substances around our bodies. It delivers essential nutrients to every cell, and it transports waste products to waste-disposal sites—the lungs, the skin, and the kidneys. The circulatory system is an organ system that includes the heart, the blood vessels, and the blood itself. It has three functions: 1. to transport materials (i.e., nutrients and oxygen) and cells from one place to another 2. to defend the body against invasion by harmful organisms by taking white blood cells to an area of injury or infection 3. to maintain a constant body temperature Introduction Your body has a network of blood vessels—hollow tubes—that move blood and nutrients. A pumping organ—the heart—pushes blood through this network of vessels. Watch this video to start looking at this incredible system: https://youtu.be/tF9-jLZNM10 Complete the following. 1) Fill in the blanks: 1. Most of the cells inside of your body ________________ . If a cell is _____________ or needs to get rid of ______________, it can’t simply move itself to the part of your body where it needs to go. -
38.3 Joints and Skeletal Movement.Pdf
1198 Chapter 38 | The Musculoskeletal System Decalcification of Bones Question: What effect does the removal of calcium and collagen have on bone structure? Background: Conduct a literature search on the role of calcium and collagen in maintaining bone structure. Conduct a literature search on diseases in which bone structure is compromised. Hypothesis: Develop a hypothesis that states predictions of the flexibility, strength, and mass of bones that have had the calcium and collagen components removed. Develop a hypothesis regarding the attempt to add calcium back to decalcified bones. Test the hypothesis: Test the prediction by removing calcium from chicken bones by placing them in a jar of vinegar for seven days. Test the hypothesis regarding adding calcium back to decalcified bone by placing the decalcified chicken bones into a jar of water with calcium supplements added. Test the prediction by denaturing the collagen from the bones by baking them at 250°C for three hours. Analyze the data: Create a table showing the changes in bone flexibility, strength, and mass in the three different environments. Report the results: Under which conditions was the bone most flexible? Under which conditions was the bone the strongest? Draw a conclusion: Did the results support or refute the hypothesis? How do the results observed in this experiment correspond to diseases that destroy bone tissue? 38.3 | Joints and Skeletal Movement By the end of this section, you will be able to do the following: • Classify the different types of joints on the basis of structure • Explain the role of joints in skeletal movement The point at which two or more bones meet is called a joint, or articulation. -
The ENDOCRINE SYSTEM Luteinizinghormones Hormone/Follicle-Stimulating Are Chemical Hormone Messengers
the ENDOCRINE SYSTEM LuteinizingHormones hormone/follicle-stimulating are chemical hormone messengers. (LH/FSH) They bind to specific target cells Crucial for sex cell production Growth hormone–releasingwith receptors, hormone regulate (GHRH) metabolism and the sleep cycle, and contribute Thyrotropin-releasing hormone (TRH) Regulatesto thyroid-stimulating growth and hormone development. release The endocrine glands and organs secrete Corticotropin-releasing hormone (CRH) Regulatesthese to release hormones of adrenocorticotropin all over that is vitalthe to body. the production of cortisol (stress response hormone). The hypothalamus is a collection of specialized cells that serve as the central relay system between the nervous and endocrine systems. hypothalamus Growth hormone-releasing hormone (GHRH) Thyrotropin-releasing hormone (TRH) Regulates the release of thyroid-stimulating hormones Luteinizing hormone/follicle-stimulating hormone (LH/FSH) Crucial for sex cell production Corticotropin-releasing hormone (CRH) Regulates the release of adrenocorticotropin that’s vital to the production of cortisol 2 The hypothalamus translates the signals from the brain into hormones. From there, the hormones then travel to the pituitary gland. Located at the base of the brain inferior to the hypothalamus, the pituitary gland secretes endorphins, controls several other endocrine glands, and regulates the ovulation and menstrual cycles. pituitary gland 3 The anterior lobe regulates the activity of the thyroid, adrenals, and reproductive glands by producing hormones that regulate bone and tissue growth in addition to playing a role in the absorption of nutrients and minerals. anterior lobe Prolactin Vital to activating milk production in new mothers Thyrotropin Stimulates the thyroid to produce thyroid hormones vital to metabolic regulation Corticotropin Vital in stimulating the adrenal gland and the “fight-or-flight” response 4 The posterior lobe stores hormones produced by the hypothalamus.