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2018 Annual Scientific Meeting Program In collaboration with 2209 Dickens Road Richmond, VA 23230-2005 (804) 565-6396 | Fax (804) 282-0090 www.asia-spinalinjury.org ASIA 2018 Annual Scientifi c Meeting 1 Now Recruiting SPRING Trial: Acute Spinal Cord Injury Come visit us at our booth & find out more about our Phase 2b/3 VX- 210 Trial Booth #10 Exhibit Hours Wednesday, May 2 7:00 am – 3:30 pm Thursday, May 3 Craig H. Neilsen Foundation’s funding is dedicated to supporting 7:00 am – 3:15 pm both programs and scientific research to improve the quality of life for those affected by and living with spinal cord injury. For more information www.vertexscitrial.com NCT02669849 www.chnfoundation.org © 2018 Vertex Pharmaceuticals Incorporated VXMA-HQ-51-00011 │ 04/2018 2 ASIA 2018 Annual Scientifi c Meeting ASIA 2018 Annual Scientifi c Meeting 3 2018 Lifetime Achievement Richard P. Bunge, MD Award Recipients Mary Bartlett Bunge, PhD Theirs was a true and productive partnership, not only Mary Bartlett Bunge, PhD and the Journal of Cell Biology. She has worked as Chair or mem- in their personal lives, but also as a research team. Mary Bartlett Bunge, PhD, ber of 37 Society and Organization Boards and Panels, including is currently Professor of Cell the NIH Director Search Committee and the National Task Force for the NIH Strategic Plan. Richard P. Bunge, MD injury that provided novel and Biology, Neurological Surgery, fundamental insights into the and Neurology and the Like her collaborator and partner, Dr. Mary Bunge received Richard P. Bunge, MD, spent nature of that injury, includ- Christine E. Lynn Distinguished the Wakeman Award (1996) for her seminal contributions to his lifetime at the forefront of Professor of Neuroscience at ing demyelination and axonal the fi eld of spinal cord injury repair, and also the Christopher research efforts to understand the Miller School of Medicine, degeneration. Reeve Research Medal for Spinal Cord Repair (2001), a Javits and improve the processes working in The Miami Project Neuroscience Investigator Award for 1998-2005, and was the fi rst of repair in the nervous sys- After obtaining his MD de- to Cure Paralysis. Dr. Bunge recipient of the Mika Salpeter Women in Neuroscience Lifetime tem. While a medical student, gree from the University of earned her MS degree in Achievement Award (2000). She has also received the Lois Pope he discovered that myelin Wisconsin Medical School Medical Physiology under the- LIFE International Research Award (2005). In 2013, she was could be broken down and in 1960, Dr. Bunge went to sis advisor, R.F. Schilling, at the elected to the National Academy of Medicine. At the University of then reformed in the adult Columbia University to learn University of Wisconsin Medical Miami, she was inducted in 2005 into Iron Arrow, the highest hon- mammalian spinal cord, a rev- the technique of nerve tissue School (1955), and her PhD in Mary Bartlett Bunge, PhD or at the University and named the Distinguished Faculty Scholar olutionary idea in the 1950s. culture with one of its found- Zoology-Cytology with advi- for 2012. Dr. Bunge has mentored 15 doctoral students and 32 This discovery initiated his ers, Dr. Margaret R. Murray. sor, Dr. Hans Ris (1960). She was an NINDB Post-Doctoral Fellow post-doctoral fellows. Mentoring trainees has been an important (1960-62) in the Department of Anatomy (Dr. George D. Pappas) lifelong love of research and Mary Bunge often has said, “We completed each other.” He then held faculty appoint- priority. As a member (1993-2007) and Chair of the Development and Laboratory for Cell Physiology (Dr. Margaret R. Murray) at abandonment of his goal to become a physician. This work led ments in anatomy at Columbia University College of Physicians of Women’s Careers in Neuroscience Committee, Society for Columbia University College of Physicians and Surgeons. to the discovery, with Dr. Mary Bunge, of the mechanism of CNS and Surgeons from 1962 to 1970, and in anatomy and neurobi- Neuroscience (Sven, 1993-2007), she instituted a variety of men- myelination and the demonstration of the connections between ology at Washington University School of Medicine from 1970 to Pursuing an overall goal of promoting nervous system repair, toring activities that has led recently to a mentoring luncheon held forming myelin and oligodendrocytes. 1989, before joining the faculty at the Leonard M. Miller School of Dr. Mary Bunge has been a pioneer in identifying the structure and every year at the annual SfN meeting. Dr. Bunge founded the Medicine at the University of Miami. He held the Kinetic Concepts function of cells that form myelin and, more recently, in developing Mary Bartlett Bunge Distinguished Women in Cell Biology Lecture While still a young in- Distinguished Chair in Neurological Surgery and was Scientifi c a new spinal cord injury model and novel combination strategies to Series that has brought an outstanding lecture and mentoring ses- vestigator, Dr. Bunge Director of The Miami Project to Cure Paralysis. improve repair of the injured spinal cord. Her laboratory conducts sions to the University community every year since 2005. and his colleagues, preclinical studies aimed at developing neuroprotective and neu- Theirs was a true and productive partnership, not only in their per- primarily Dr. Patrick Throughout his distinguished career, he published 153 peer- ro-regenerative therapies for spinal cord injuries. These therapies sonal lives, but also as a research team. As Mary Bunge often Wood, developed a reviewed manuscripts in high quality neuroscience journals and include the transplantation of genetically modifi ed Schwann cells to has said, “We completed each other.” Their shared goal of apply- cell culture system was awarded an impressive array of grants from the NIH. Dr. Bunge facilitate regeneration in damaged spinal cords. The Bunge work ing the basic science fi ndings to clinical situations helped drive in which myelination received Javits Neuroscience Investigator Awards from the NIH, on the effi cacy of transplanted Schwann cells in spinal cord repair the progression of “bench” studies of Schwann cell biology to the could be studied the Friedrich von Rechlinghausen Award for the Advancement of contributed to gaining approval from the FDA in 2012 for initiating “bedside” testing of autologous Schwann cell transplantation in clinical trial testing of these cells in spinal cord injured subjects. systematically and Medical Sciences in Neurofi bromatosis, the Gordon Conference spinal cord injured subjects in The Miami Project. To quote Mary Richard P. Bunge, MD fundamental discov- on Myelin Chairman Award and, with his collaborator and partner Dr. Bunge has published 47 book chapters and scholarly mono- Bunge again, “This has been such an exciting, fruitful and espe- eries elucidating the Mary, the prestigious Wakeman Award for their pioneering work in graphs and 161 peer-reviewed manuscripts. These articles have cially fulfi lling journey.” processes underlying Schwann cell-neuron interactions could tissue culture and cell biology of fetal cells, transplantation, and been cited by her peers in nearly 13,000 of their manuscripts. She Established in 1987, the ASIA Lifetime Achievement Award is pre- be made. He proposed in 1975 that cellular grafts, particularly detailed descriptions of human spinal cord injury. He was named has received numerous NIH grants, including a current award sup- sented to an individual(s) who made a signifi cant contribution to of Schwann cells, could be prepared in tissue culture and then a Heiner Sell Memorial Lecturer by ASIA, a lecture he never gave porting the Bunge’s collaboration that has provided uninterrupted the world of spinal cord injury care. Criteria include: career dedica- transplanted to enhance repair in the CNS. Accordingly, he pi- due to his untimely death in 1996. Upon his passing, an edition of funding for 45 years. The Christopher and Dana Reeve Foundation tion; peer recognition; professional competence; and recognized oneered studies of the biology of adult human Schwann cells Experimental Neurology was dedicated in his memory, in which also provided funding for many years. Dr. Bunge has served as Chair achievement. Each recipient is chosen from a slate of member as a prelude to possible autotransplantation into sites of spinal the Section Editors Drs. Jerry Silver and Scott Whittamore wrote, or member of 13 NIH study sections and Councils for the NINDS and submitted candidates. cord injury in the human. In 1990, he initiated an extensive and “Those of us who work in these areas owe a great debt of gratitude the American Society for Cell Biology. She has served on editorial detailed characterization of the pathology of human spinal cord to Richard Bunge and his legacy of scientifi c achievements.” boards for Experimental Neurology, the Journal of Neurocytology, Editorial Content by Naomi Kleitman, PhD 4 ASIA 2018 Annual Scientifi c Meeting ASIA 2018 Annual Scientifi c Meeting 5 Previous Sell Lecturers 2017 Jacqueline C. Bresnahan, PhD, San Francisco, California 1999 Ake Seiger, MD, PhD, Stockholm, Sweden Modeling SCI in Animals To Understand The Human Human Fetal CNS Tissue Transplantation to the Injured Condition, and Vice Versa Spinal Cord 2016 Steven Kirshblum, MD, West Orange, New Jersey 1998 Giles S. Brindley, MD, London, England When You Come to a Fork in the Road: Lessons Learned Neuroprostheses in SCI The Distinguished G. Heiner Sell Lectureship and a Map for the Future 1997 O. Lars Olson, MD, Stockholm, Sweden William “Zev” Rymer, MD, PhD 2015 Michael L. Boninger, MD, Pittsburgh, Pennsylvania Spinal Cord Repair Strategies, Possibilities and The Future of Neural Prosthetics in SCI Limitations The G. Heiner Sell Lectureship was inaugurated in 1982, following the untimely death 2014 W. Dalton Dietrich III, PhD, Miami, Florida 1996 Charles H. Tator, MD, PhD, Toronto, Ontario of Dr. Sell the previous year.
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  • Mary Bartlett Bunge 40
    EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F.
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