Tolerance and M2 (Alternative) Macrophage Polarization Are Related Processes Orchestrated by P50 Nuclear Factor B
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor B Chiara Portaa,b, Monica Rimoldic, Geert Raesd, Lea Brysd, Pietro Ghezzie, Diana Di Libertof, Francesco Dielif, Serena Ghislettig, Gioacchino Natolig, Patrick De Baetselierd, Alberto Mantovanic,h, and Antonio Sicaa,b,1 aFondazione Humanitas per la Ricerca, 20089 Rozzano, Italy; bDipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, University of Piemonte Orientale A. Avogadro, 28100 Novara, Italy; cIstituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, 20089 Rozzano, Italy; dLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, and Department of Molecular ad Cellular Interactions, 1050 Brussels, Belgium; eBrighton and Sussex Medical School, Brighton BN1 9PX, United Kingdom; fDipartimento di Biopatologia e Metodologie Biochimediche, Universita`di Palermo, 90134 Palermo, Italy; gDepartment of Experimental Oncology, European Institute of Oncology at IFOM-IEO Campus, 20139 Milan, Italy; and hUniversity of Milan, 20133 Milan, Italy Edited by Michael Karin, University of California, San Diego School of Medicine, La Jolla, CA, and approved July 22, 2009 (received for review October 6, 2008) Cells of the monocyte–macrophage lineage play a central role in the regulators (9). For instance, p50 and p52 homodimers act as orchestration and resolution of inflammation. Plasticity is a hallmark repressors because these proteins lack a transcription activation of mononuclear phagocytes, and in response to environmental sig- domain, present in RelA, RelB, v-Rel, and c-Rel (7). Accumulation nals these cells undergo different forms of polarized activation, the of p50 homodimers has been observed in endotoxin-tolerant mac- extremes of which are called classic or M1 and alternative or M2.
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