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Custom Peptide & Chemistry Services Custom Peptide & Chemistry Services Certified to ISO 9001:2015 Peptides International was established in 1983 and is located in Louisville, Kentucky. The PI laboratories, updated and expanded in 2007 and again in 2015/2016, consist of well-equipped R&D labs, a 100-liter reactor system, in-process control instrumentation, purification systems and high-capacity freeze dryers. Incoming raw materials, as well as finished goods, are analyzed using state-of-the-art methods including HPLC, MS, AAA, UV and FTIR spectroscopy, polarimetry, and traditional organic analytical techniques. With these capabilities and the experience of its staff, Peptides International is able to offer efficient and cost effective solutions to serve the challenging needs of modern peptide-based drug discovery and development. Product Quality and Value • Strict Confidentiality • Proactive Project Management • Friendly Service The Complex Custom Peptide Technology Platform Peptides International has made a major commitment in personnel and equipment that significantly increases the breadth of its technology in peptide science. These resources, together with the company’s broad background in solving custom peptide challenges, now offers researchers a COMPLEX CUSTOM PEPTIDE TECHNOLOGY PLATFORM from which to develop new projects. The platform assures an integrated company-wide effort that not only meets researcher’s immediate synthetic needs, but can offer additional services in areas such as analytical testing, technology/process development, and scale-up. Examples of several elements of the platform are described below. Our team of scientists (see back) has expertise and experience in each of the areas of the platform and welcomes the opportunity to consult with researchers at any point in the development of their projects. Multi-disulfide Peptides Linker Biotin Interested in mini-proteins with multiple disulfide bonds? PI re- searchers have extensive experience folding these highly com- Shk plicated molecules to their biologically active forms. Examples include native molecules and analogs of conotoxins, defensins, FITC hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc). They can also customize with labels such as TAMRA, FITC Arg-1 or Biotin using a mini-PEGTM spacer (example at right). TMR Lys-22 O Peptide-Protein Conjugates H KLH N N SH Peptide O Peptide-protein conjugates have a variety of applications, including the SULFHYDRYLCNTAINING O HAPTEN PEPTIDE WITH stimulation of antibodies for immunization KLH (Keyhole Limpet Hemo- ALEIMIDEACIVATED TERMINAL CSTEINE cyanin) (see example at right) or BSA (Bovine Serum Albumin). These CAIE PTEIN conjugates can be customized as needed, including combinations with proteins such as Ovalbumin or Ferritin. Selective heterobifunctional S crosslinkers allow for selective attachment of a Cys-containing peptide O H Peptide to the protein of your choice. Using KLH-MCC or Maleimide-Activated KLH N N O BSA will help streamline this reaction, and the products (KLH-6000-PI O and BSA-6001-PI, respectively) are conveniently kept in stock at all times. CAIEPPTIDE CONJUGATE ICI CHI CC hν Peptide Derivatives Fluorescence resonance energy transfer (FRET) occurs when excitation energy is transferred from an excited fluorescent donor to a quenching DABCYL EDANS acceptor in a distance-dependent manner. Cleavage of a scissile peptide DONOR CH bond within a fluorescence quenched substrate leads to separation of the intramolecular donor-acceptor pair, thus allowing an increase in ENZYME fluorescence. The fluorescence increase is proportional to the amount of peptide hydrolyzed. If you need to design a substrate for a newly discovered enzyme or application, contact our specialists to begin your Substrates by DesignTM project today. EDANS DABCYL AI C IA Contact us for additional examples in these areas Post Translational Modification Peptidomimetics • Glycosylation • Hydroxyethylene Isostere • Phosphorylation • Reduced Peptide Bonds • Fatty Acylation • Aldehydes • Pegylation • Chloromethylketones • Cyclization (head-to-tail, lactam, thioether) • Depsipeptides • Disulfide Bonds • Phosphonates • Stapling Peptide Synthesis Multi-step Organic Synthesis • Classical/Solution • Novel Amino Acid Derivatives • Solid-Phase • Stereo Selective Synthesis • Native Chemical Ligation • Special Protecting Groups • Dendrimeric RGD Platforms • Natural Product Synthesis • Chromogenic / Fluorogenic Substrates Peptides International has: > 7500 catalog products + custom & contract manufacturing. • Internal production + distribution. • A high purity, high quality focus. • Highly experienced team coupled with company longevity. • A 35 year relationship with the Peptide Institute. • Independence, with a flexible facility & state of the art equipment . • Certification to ISO 9001:2015. • Comprehensive analytical services. • Competitive cost structure & pricing. • Timely quoting and delivery, with very favorable logistics. • Complete project confidentiality. • A CRO business model with scale-up capability: 1 mg – 0.5 kg. • A strategic partnership for your cGMP production. • Certification as a minority, woman-owned business. CATALOG PRODUCTS CUSTOM CHEMISTRY SERVICES TM EXCELLENCE COMPOUNDED • RGD Platform Made in USA • High Purity, Quality and Value • ProTx-II & Other Toxins • Design Consultation • Strict Confidentiality • Biologically Active Peptides • Chemistry Development Key literature citations and patents • Friendly Service • Substrates & Inhibitors • Process Scale-up referring to Peptides International • Proactive Project Management • dPEGs and Linkers • Pilot-Scale Synthesis products and services PEPNET. Full list @ PEPNET.COM • Solution & Solid Phase • Substrates by DesignTM Peptides International, Inc. 11621 Electron Drive Louisville, KY 40299 USA phone: +1-502-266-8787 toll free phone: +1-800-777-4779 (US and Canada) fax: +1- 502-267-1329 email: [email protected].
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