Custom Peptide & Chemistry Services
Certified to ISO 9001:2015 Peptides International was established in 1983 and is located in Louisville, Kentucky. The PI laboratories, updated and expanded in 2007 and again in 2015/2016, consist of well-equipped R&D labs, a 100-liter reactor system, in-process control instrumentation, purification systems and high-capacity freeze dryers. Incoming raw materials, as well as finished goods, are analyzed using state-of-the-art methods including HPLC, MS, AAA, UV and FTIR spectroscopy, polarimetry, and traditional organic analytical techniques. With these capabilities and the experience of its staff, Peptides International is able to offer efficient and cost effective solutions to serve the challenging needs of modern peptide-based drug discovery and development.
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The Complex Custom Peptide Technology Platform
Peptides International has made a major commitment in personnel and equipment that significantly increases the breadth of its technology in peptide science. These resources, together with the company’s broad background in solving custom peptide challenges, now offers researchers a COMPLEX CUSTOM PEPTIDE TECHNOLOGY PLATFORM from which to develop new projects. The platform assures an integrated company-wide effort that not only meets researcher’s immediate synthetic needs, but can offer additional services in areas such as analytical testing, technology/process development, and scale-up. Examples of several elements of the platform are described below. Our team of scientists (see back) has expertise and experience in each of the areas of the platform and welcomes the opportunity to consult with researchers at any point in the development of their projects.
Multi-disulfide Peptides Linker Biotin Interested in mini-proteins with multiple disulfide bonds? PI re- searchers have extensive experience folding these highly com- Shk plicated molecules to their biologically active forms. Examples include native molecules and analogs of conotoxins, defensins, FITC hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc). They can also customize with labels such as TAMRA, FITC Arg-1 or Biotin using a mini-PEGTM spacer (example at right). TMR
Lys-22 Peptide-Protein Conjugates H KLH H Peptide Peptide-protein conjugates have a variety of applications, including the H C AI I HAP P P I I H stimulation of antibodies for immunization KLH (Keyhole Limpet Hemo- A I I AC I A I A C I cyanin) (see example at right) or BSA (Bovine Serum Albumin). These CA I P I conjugates can be customized as needed, including combinations with proteins such as Ovalbumin or Ferritin. Selective heterobifunctional crosslinkers allow for selective attachment of a Cys-containing peptide H Peptide to the protein of your choice. Using KLH-MCC or Maleimide-Activated KLH BSA will help streamline this reaction, and the products (KLH-6000-PI and BSA-6001-PI, respectively) are conveniently kept in stock at all times. CA I P P I C A