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Curriculum Vitae Barbara Imperiali Curriculum Vitae Barbara Imperiali Department of Biology and Department of Chemistry Massachusetts Institute of Technology Cambridge, MA 02139 Education: 1979 University College London, London, England B.Sc. Medicinal Chemistry. First Class (Honours) 1983 Massachusetts Institute of Technology, Cambridge, MA Ph.D. in Synthetic Organic Chemistry Date of Birth: January 1, 1957 Professional Experience: 1983 Massachusetts Institute of Technology Postdoctoral Associate with Dr. S. Masamune 1984 Brandeis University Postdoctoral Associate with Dr. R. H. Abeles 1986 Carnegie Mellon University Assistant Professor of Chemistry 1989 California Institute of Technology Assistant Professor of Chemistry 1995 California Institute of Technology Associate Professor of Chemistry 1997 California Institute of Technology Professor of Chemistry 1999 Massachusetts Institute of Technology Ellen Swallow Richards Professor of Chemistry 2002 Massachusetts Institute of Technology Ellen Swallow Richards Professor of Chemistry and Professor of Biology 2004 Massachusetts Institute of Technology Class of 1922 Professor of Chemistry and Professor of Biology 2011 Broad Institute Associate Member Honors: 1979 Kennedy Memorial Trust Graduate Fellowship 1985 American Cancer Society Postdoctoral Fellowship 1992 Associated Students of the California Institute of Technology (ASCIT) Award for Excellence in Teaching 1992 Lilly Grantee Award 1993 Alfred P. Sloan Research Fellow 1993 Camille and Henry Dreyfus Teacher-Scholar Award 1993 Richard M. Badger Teaching Award 1993 Zeneca Chemistry Award for Excellence in Chemistry 1994 Graduate Student Council Award for Exceptional Teaching and Mentorship 1995 ASCIT Award for Excellence in Teaching 1996 American Chemical Society - Arthur C. Cope Scholar Award 1998 5th Annual Richard P. Feynman Award for Excellence in Teaching (Caltech) 2001 Elected to the American Academy of Arts and Sciences 2002 MIT School of Science Award for Excellence in Undergraduate Education 2003 Margaret McVicar Faculty Fellow (in recognition of contributions to education at MIT) 2004 Admitted as a Fellow of the Royal Society of Chemistry (FRSC) 2006 American Chemical Society - Ronald Breslow Award for Achievement in Biomimetic Chemistry 2006 American Peptide Society - Vincent du Vigneaud Award for Peptide Chemistry 2006 Protein Society - Emil T. Kaiser Award 2010 Elected to the National Academy of Sciences National and International Professional Activities: 1992 Co-Chair and organizer of the first Gordon Research Conference on Bioorganic Chemistry. 1993-1994 Member, Nominating Committee, Division of Biological Chemistry, American Chemical Society. 1994 Program Committee Member for Fourteenth American Peptide Symposium, Columbus, OH. 1995 - Member, Editorial Board Archives of Biochemistry and Biophysics. 1995 Member, Organizing Committee 15th Enzyme Mechanisms Conference, Naples, FL. 1996 Co-Chair of Chemistry and Biology of Peptides Gordon Research Conference, Ventura, CA 1998. 1996-2000 Member, National Institutes of Health - Bioorganic and Natural Products Study Section. 1996-2000 At-large member of the Council of the Gordon Research Conferences. 1996-2008 Member, Board of Consulting Editors Bioorganic and Medicinal Chemistry Letters and Bioorganic and Medicinal Chemistry. 1996 - Member, Editorial Board Current Opinions in Chemical Biology. 1997 - Member, Editorial Board Chemistry and Biology. 1997-2002 Council Member, American Peptide Society. 1997-2000 Council Member, Division of Biological Chemistry, American Chemical Society. 1998-2000 Protein Design Labs, Inc. Member Scientific Advisory Board. 1999-2002 Member, Advisory Board for Novartis, Basel, Switzerland. 1999-2007 Member, Editorial Advisory Board Organic Letters. 2000-2002 Co-organizer, NSF Workshop in Physical Organic Chemistry. 2000-2002 Member, Editorial Advisory Board Journal of Organic Chemistry. 2000 - Member, Editorial Advisory Board Biochemistry. 2000-2002 Member, Editorial Advisory Board Accounts of Chemical Research. 2000 - Member, Editorial Advisory Board Chemistry – A European Journal. 2000-2006 Associate Editor, Chemical Biology (USA) – Chemical Communications. 2000- Member and Chair, Scientific Advisory Board Novartis Institute for Tropical Diseases, Singapore. 2001-2006 Member, Scientific Advisory Board Syntonix, Waltham, MA. 2003-2008 Member Advisory Board Complex Carbohydrate Resource Center, University of Georgia, Athens, GA. 2005-2007 Member, Novartis Foundation Scientific Advisory Panel. 2006-2009 Member, Whitehead Institute Advisory Board. 2007-2008 Associate Editor (The Americas) - Bioorganic and Medicinal Chemistry. 2008-2011 Director – MIT Chemistry Biology Interface NIH Training Program. 2010 - Editorial Advisory Board – Journal of the American Chemical Society 2011 - Co-chair, Editorial Advisory Board – ChemBioChem. 2012-2013 Member, Nominating Committee, ASBMB. 2014 - Member, Steering Committee, NIH Workshop on Mentoring New Investigators in Organic and Biological Chemistry. 2015 Co-Founder AssayQuant Technologies. Barbara Imperiali - Publications 1. "Stereoselective Aldol Condensation: Use of Chiral Boron Enolates," Masamune, S.; Choy, W.; Kerdesky, F. A. J.; Imperiali, B. J. Am. Chem. Soc. 1981, 103, 1566-1568. 2. "Synthesis of Ansamycins: The Ansa Chain of Rifamycin S," Masamune, S.; Imperiali, B.; Garvey, D. S. J. Am. Chem. Soc. 1982, 104, 5528-5531. 3. "Synthesis of Tylonolide, the Aglycone of Tylosin," Jackson, W. P.; Lu, L. D-L.; Imperiali, B.; Choy, W.; Tobita, H.; Masamune, S. In Strategies and Tactics in Organic Synthesis; Lindberg, T., Ed.; Academic Press: Orlando, 1984; p 123-153. 4. "A Versatile Synthesis of Peptidyl Fluoromethyl Ketones," Imperiali, B.; Abeles, R. H. Tetrahedron Lett. 1986, 27, 135-138. 5. "Inhibition of Serine Proteases by Peptidyl Fluoromethyl Ketones," Imperiali, B.; Abeles, R. H. Biochemistry, 1986, 25, 3760-3767. 6. "Biosynthetic Thiolase from Zoogloea ramigera. 1. Preliminary Characterization and Analysis of the Proton Transfer Reaction," Davis, J. T.; Moore, R. N.; Imperiali, B.; Pratt, A. J; Kobayashi, K.; Masamune, S.; Sinskey, A. J.; Walsh, C. T.; Fukui, T.; Tomita, K. J. Biol. Chem. 1987, 262, 82-89. 7. "Extended Binding Inhibitors of Chymotrypsin which Interact with Leaving Group Subsites S1'- S3'," Imperiali, B.; Abeles, R. H. Biochemistry, 1987, 26, 4474-4477. 8. "Synthetic Fluoropeptides as Pharmacologically Useful Compounds," Imperiali, B. In Advances in Biotechnological Processes (Synthetic Peptides in Biotechnology); Mizrahi, A., Ed.; Alan R. Liss: New York, 1988; p 97-129. 9. "Synthesis of Dolichols via Asymmetric Hydrogenation of Plant Polyprenols," Imperiali, B.; Zimmerman, J. W. Tetrahedron Lett. 1988, 29, 5343-5344. 10. "Synthesis of Dolichylpyrophosphate-Linked Oligosaccharides," Imperiali, B.; Zimmerman, J. W. Tetrahedron Lett. 1990, 31, 6485-6488. 11. "Differences between Asn-Xaa-Thr-Containing Peptides: A Comparison of Solution Conformation and Substrate Behavior with Oligosaccharyltransferase," Imperiali, B.; Shannon, K. L. Biochemistry, 1991, 30, 4374-4380. 12. "(S)-a-Amino-(2,2'-bipyridine)-6-Propanoic Acid: A Versatile Amino Acid for de novo Metalloprotein Design," Imperiali, B.; Fisher, S. L. J. Am. Chem. Soc. 1991, 113, 8527-8528. 13. "Stereoselective Synthesis and Peptide Incorporation of (S)-a-Amino-(2,2'-bipyridine)-6-Propanoic Acid," Imperiali, B.; Fisher, S. L. J. Org. Chem. 1992, 57, 757-759. 14. "A Conformational Study of Peptides with the General Structure Ac-L-Xaa-Pro-D-Xaa-L-Xaa-NH2: Spectroscopic Evidence for a Peptide with Significant b-Turn Character in Water and Dimethyl Sulfoxide," Imperiali, B.; Fisher, S. L.; Moats, R. A.; Prins, T. J. J. Am. Chem. Soc. 1992, 114, 3182- 3188. 15. "Role of Peptide Conformation in Asparagine-Linked Glycosylation," Imperiali, B.; Shannon, K. L.; Rickert, K. W. J. Am. Chem. Soc. 1992, 114, 7942-7944. 16. "A Mechanistic Proposal for Asparagine-Linked Glycosylation," Imperiali, B.; Shannon, K. L.; Unno, M.; Rickert, K. W. J. Am. Chem. Soc. 1992, 114, 7944-7945. 17. "Chemoenzymatic Synthesis of 2-Amino-3-(2,2'-bipyridinyl)-Propanoic Acids," Imperiali, B.; Prins, T. J.; Fisher, S. L. J. Org. Chem. 1993, 58, 1613-1616. 18. "The Reverse Turn as a Template for Metal Coordination," Imperiali, B.; Kapoor, T. M. Tetrahedron 1993, 49, 3501-3510. 19. "Semisynthesis of Bipyridyl-Alanine Cytochrome c Mutants: Novel Proteins with Enhanced Electron-Transfer Properties," Wuttke, D. S.; Gray, H. B.; Fisher, S. L.; Imperiali, B. J. Am. Chem. Soc. 1993, 115, 8455-8456. 20. "Investigation of the Origins of Specificity and Reactivity in N-Linked Protein Glycosylation," Imperiali, B.; Rickert, K. W. ACS Symposium Series Publication 551; Hedin, P. A.; Menn, J. J.; Hollingworth, R. M. American Chemical Society: Washington, DC, 1994; pp 425-435. 21. "Structural and Functional Characterization of a Constrained Asx-Turn Motif," Imperiali, B.; Spencer, J. R.; Struthers, M. D. J. Am. Chem. Soc. 1994, 116, 8424-8425. 22. "Coenzyme-Amino Acid Chimeras: New Residues for the Assembly of Functional Proteins," Imperiali, B.; Sinha Roy, R. J. Am. Chem. Soc. 1994, 116, 12083-12084. 23. "Conformational Implications of Asparagine-Linked Glycosylation," Imperiali, B.; Rickert, K. W. Proc. Natl. Acad. Sci. USA, 1995, 92, 97-101. PMCID: PMC42824 24. "Stereoselective Synthesis and Peptide Incorporation of a Pyridoxal Coenzyme-Amino Acid Chimera" Imperiali, B.; Sinha Roy, R. J. Org. Chem. 1995, 60, 1891-1894. 25. "Sulfhydryl Modification of the Yeast Wbp1p Subunit Inhibits Oligosaccharyl Transferase
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