Allergy Testing
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Wo 2010/075090 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 1 July 2010 (01.07.2010) WO 2010/075090 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 409/14 (2006.01) A61K 31/7028 (2006.01) kind of national protection available): AE, AG, AL, AM, C07D 409/12 (2006.01) A61P 11/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2009/068073 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 15 December 2009 (15.12.2009) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, (26) Publication Language: English TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/122,478 15 December 2008 (15.12.2008) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): AUS- ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, PEX PHARMACEUTICALS, INC. -
Ophthalmic Antihistamines
Ophthalmics for Allergic Conjunctivitis Review 04/12/2011 Copyright © 2004 - 2011 by Provider Synergies, L.L.C. All rights reserved. Printed in the United States of America. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, digital scanning, or via any information storage and retrieval system without the express written consent of Provider Synergies, L.L.C. All requests for permission should be mailed to: Attention: Copyright Administrator Intellectual Property Department Provider Synergies, L.L.C. 10101 Alliance Rd, Ste 201 Cincinnati, Ohio 45242 The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, -
Potential Drug-Drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine
Original Article Potential Drug-drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine Arjun Singh1, Richa Chaudhary1, Prayas Verma2, Nilanchal Trivedi3,*, Md. Shamim4 1Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 2Teerthanker Mahaveer Dental College and Research Centre, TMU Moradabad, Uttar Pradesh, INDIA. 3Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 4LCP College of Pharmacy Baghpat, Abdul Kalam Technical University (AKTU), Uttar Pradesh, INDIA. ABSTRACT Introduction: COVID-19 is a pandemic disaster and a health emergency of prime focus for all the world economies. Various prophylactic treatments are considered to combat the disease. Hydroxychloroquine drug is one such option that is given much attention as an armor against SARS COV-2 pandemic. Evaluation and assessment of drug interactions and ADRs is required from ethical concern to justify the use of HCQ on such large scale. Methods: We have performed an analysis of HCQ drug interactions on Micromedex®. We have reviewed literature of HCQ pharmacokinetic properties, ADRs/ ADEs and toxicities associated with the use of HCQ drug on PubMed, Google Scholar and CDC database. Results: There are around 180 drug interactions possible with HCQ. Out of them 13 are of contraindicated severity level and other 165 are of major severity and 2 of them are moderately severe. Most of the interactions are coupled with QT prolonging agents (170), Cardiac arrhythmias is possible with the concomitant use of at least 2 drugs, 4 drugs leads to Torsade de points. System organ level ADRs are also evaluated along with various precautions, warnings and contraindications. -
Epinastine Hcl Ophthalmic Solution) 0.05% Sterile
NDA 21-565/S-005 Page 2 ELESTAT™ (epinastine HCl ophthalmic solution) 0.05% Sterile DESCRIPTION ELESTAT™ (epinastine HCl ophthalmic solution) 0.05% is a clear, colorless, sterile isotonic solution containing epinastine HCl, an antihistamine and an inhibitor of histamine release from the mast cell for topical administration to the eyes. Epinastine HCl is represented by the following structural formula: C16H15N3 • HCl Mol. Wt. 285.78 Chemical Name: 3-Amino-9, 13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride Each mL contains: Active: Epinastine HCl 0.05% (0.5 mg/mL) equivalent to epinastine 0.044% (0.44mg/mL); Preservative: Benzalkonium chloride 0.01%; Inactives: Edetate disodium; purified water; sodium chloride; sodium phosphate, monobasic; and sodium hydroxide and/or hydrochloric acid (to adjust the pH). ELESTAT™ has a pH of approximately 7 and an osmolality range of 250 to 310 mOsm/kg. CLINICAL PHARMACOLOGY Epinastine is a topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast cell. Epinastine is selective for the histamine H1-receptor and has affinity for the histamine H2 receptor. Epinastine also possesses affinity for the α1-, α2-, and 5-HT2 –receptors. Epinastine does not penetrate the blood/brain barrier and, therefore, is not expected to induce side effects of the central nervous system. Fourteen subjects, with allergic conjunctivitis, received one drop of ELESTAT™ in each eye twice daily for seven days. On day seven average maximum epinastine plasma concentrations of 0.04 ± 0.014 ng/ml were reached after about two hours indicating low systemic exposure. -
Allergy Skin Testing: Patient Instructions and Consent Form
ALLERGY SKIN TESTING: PATIENT INSTRUCTIONS AND CONSENT FORM Skin tests are a method of testing for allergic reactions to substances, or allergens, in the environment. A test consists of introducing small amounts of allergens into the skin and noting the development of a positive reaction, which consists of a wheal (swelling) and flare (surrounding area of redness). We employ the prick method, where the skin is pricked with a sharp device that introduces the allergen into the skin. Other allergy testing options include injecting the allergen with needles or going to a lab for blood tests. The entire testing process will take about 30 minutes. We test a variety of important allergens that are found in the Central Florida area including trees, grasses, weeds, molds, dust mites, and animal dander. After administering the allergens, we wait approximately 20 minutes to review the results. A positive reaction occurs when the skin becomes red, raised, and itchy. This skin reaction will gradually dissipate within 30‐60 minutes. Some people will experience local swelling beginning 4‐8 hours after testing. This is not serious and typically no treatment is required. It should disappear in the next few days. Less than 1% of patients may develop a systemic reaction to skin testing, which may consist of any or all of the following symptoms: itchy eyes, nose, or throat, nasal congestion, runny nose, tightness in the throat or chest, wheezing, lightheadedness, nausea or vomiting, hives, or anaphylactic shock. This is very rare, but in the event of such reactions, the staff is fully prepared and emergency equipment is readily available. -
Urticaria: Current Opinions About Etiology, Diagnosis and Therapy
Acta Derm Venereol 2007; 87: 196–205 REVIEW ARTICLE Urticaria: Current Opinions about Etiology, Diagnosis and Therapy Torsten ZUBERBIER and Marcus MAURER Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité – Universitätsmedizin, Berlin, Germany In the last few decades an increasing understanding of British Association of Dermatologists (4) and the most the pathomechanisms involved in urticaria has highlight recent European Academy of Allergology and Clinical ed the heterogeneity of different subtypes. According to Immunology/Global Allergy and Asthma European Net- the new European Academy of Allergology and Clinical work/European Dermatology Forum (EAACI/GA²LEN/ Immunology/Global Allergy and Asthma European Net EDF) guidelines. For preparing the latter, more than work/European Dermatology Forum (EAACI/GA²LEN/ 300 specialists from over 15 countries held a consensus EDF) guidelines, urticaria subtypes can be grouped into meeting regarding the definition, classification, routine spontaneous urticaria, which includes acute urticaria diagnosis and management of urticaria. Evidence-ba- and chronic urticaria, the physical urticarias, and other sed suggestions, prepared by a panel in advance, were urticaria disorders, including, for example, contact ur discussed using a voting system (5, 6). ticaria. Clarity of nomenclature is required not only to Due to the heterogeneity of the disease, the interpre- choose the correct measures in diagnosis and manage tation of divergent data from different centres regarding ment, but also to compare data from different studies. eliciting causes in subtypes of urticaria and their therapeu- Urticaria has a profound impact on quality of life and tic responsiveness is, however, sometimes difficult, as the performance. Effective treatment is thus required in all influence of different study populations is considerable. -
Antihistamines in the Treatment of Chronic Urticaria I Jáuregui,1 M Ferrer,2 J Montoro,3 I Dávila,4 J Bartra,5 a Del Cuvillo,6 J Mullol,7 J Sastre,8 a Valero5
Antihistamines in the treatment of chronic urticaria I Jáuregui,1 M Ferrer,2 J Montoro,3 I Dávila,4 J Bartra,5 A del Cuvillo,6 J Mullol,7 J Sastre,8 A Valero5 1 Service of Allergy, Hospital de Basurto, Bilbao, Spain 2 Department of Allergology, Clínica Universitaria de Navarra, Pamplona, Spain 3 Allergy Unit, Hospital La Plana, Villarreal (Castellón), Spain 4 Service of Immunoallergy, Hospital Clínico, Salamanca, Spain 5 Allergy Unit, Service of Pneumology and Respiratory Allergy, Hospital Clínic (ICT), Barcelona, Spain 6 Clínica Dr. Lobatón, Cádiz, Spain 7 Rhinology Unit, ENT Service (ICEMEQ), Hospital Clínic, Barcelona, Spain 8 Service of Allergy, Fundación Jiménez Díaz, Madrid, Spain ■ Summary Chronic urticaria is highly prevalent in the general population, and while there are multiple treatments for the disorder, the results obtained are not completely satisfactory. The second-generation H1 antihistamines remain the symptomatic treatment option of choice. Depending on the different pharmacokinetics and H1 receptor affi nity of each drug substance, different concentrations in skin can be expected, together with different effi cacy in relation to the histamine-induced wheal inhibition test - though this does not necessarily have repercussions upon clinical response. The antiinfl ammatory properties of the H1 antihistamines could be of relevance in chronic urticaria, though it is not clear to what degree they infl uence the fi nal therapeutic result. Before moving on to another therapeutic level, the advisability of antihistamine dose escalation should be considered, involving increments even above those approved in the Summary of Product Characteristics. Physical urticaria, when manifesting isolatedly, tends to respond well to H1 antihistamines, with the exception of genuine solar urticaria and delayed pressure urticaria. -
Association of Pediatric Atopic Dermatitis and Cataract Development and Surgery
Supplementary Online Content Jeon HS, Choi M, Byun SJ, Hyon JY, Park KH, Park SJ. Association of pediatric atopic dermatitis and cataract development and surgery. JAMA Ophthamol. Published online June 7, 2018. doi:10.1001/jamaophthalmol.2018.2166 eTable 1. List of diagnostic codes used for defining subjects eTable 2. Drug lists used for defining atopic dermatitis eTable 3. Baseline characteristics of atopic dermatitis cohort and control group eTable 4. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract development associated with atopic dermatitis (AD) and its covariates eTable 5. Cox analysis-derived hazard ratios (HRs) and 95% confidence intervals (CIs) of cataract surgery associated with atopic dermatitis (AD) and its covariates This supplementary material has been provided by the authors to give readers additional information about their work. © 2018 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/24/2021 eTable 1. List of diagnostic codes used for defining subjects Diagnoses Code numbers in KCD-6a Atopic dermatitis L20 Cataract H25, H26 Congenital malformation of eyes (anopthalmos, microphthalmos, and Q11 macrophthalmos) Congenital lens malformation Q12 Congenital malformation of anterior segment of eyes Q13 Congenital malformation of posterior segment of eyes Q14 Other congenital malformations of eyes Q15 Cataract surgery S5110, S5111, S5112, S5119 Asthma J45.0, J45.9 Allergic rhinitis J30.1, J30.2, J30.3, J30.4 aThe diagnosis was coded according to the Korean Classification of Disease, 6th edition (KCD-6, a version of the International Classification of Diseases, 10th edition, adapted for the Korean healthcare system). © 2018 American Medical Association. -
H1-Antihistamines for Chronic Spontaneous Urticaria Sharma, M., Bennett, C., Cohen, S,N
H1-antihistamines for chronic spontaneous urticaria Sharma, M., Bennett, C., Cohen, S,N. and Carter, B. Published version deposited in CURVE November 2015 Original citation & hyperlink: Sharma, M., Bennett, C., Cohen, S,N. and Carter, B. (2014) H1-antihistamines for chronic spontaneous urticaria. Cochrane Database of Systematic Reviews, volume 2014 (11): Article number CD006137. http://dx.doi.org/10.1002/14651858.CD006137.pub2 Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. CURVE is the Institutional Repository for Coventry University http://curve.coventry.ac.uk/open H1-antihistamines for chronic spontaneous urticaria (Review) Sharma M, Bennett C, Cohen SN, Carter B This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2014, Issue 11 http://www.thecochranelibrary.com H1-antihistamines for chronic spontaneous urticaria (Review) Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. TABLE OF CONTENTS HEADER....................................... 1 ABSTRACT ...................................... 1 PLAINLANGUAGESUMMARY -
Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG . -
San Diego ENT
San Diego ENT Allergy Skin Testing Instructions Make sure you review all of your medications with your doctor or the medical assistant when you are scheduled for your allergy test. DON’T’S: • Do note take over-the-counter antihistamines, cold medication, or cough syrup for 10 days prior to the test. This includes Benadryl, Claritin, Zyrtec, Allegra, loratadine, cetirizine, and fexofenadine, Tavist, Dramamine,Atarax, and others. • Do not take prescription antihistamines for 10 days prior to the test including Claritin, Zyrtec, Allegra, loratadine, cetirizine, fexofenadine, and Astelin nasal spray. Also stop antihistamine eye drops 10 days prior to testing. • Do not take beta blockers 5 days prior to testing. These include labetalol, metoprolol, carvedilol, and their brand name equivalents. • Do not take anti-acid medication for 48 hours prior to testing including Zantac, Pepcid, and Tagamet. You may continue to take proton pump inhibitors such as Prilosec, Nexium, Prevacid, Protonix, and Aciphex. • Do not take any sleeping medications for 48 hours prior to testing including Tylenol PM and Excedrin PM. DO’S: • Wear something comfortable that will allow access to your back or both upper arms on the day of testing. • You may continue to use nasal steroid sprays such as Flonase, Nasonex, Nasacort, and Rhinocort. Do not use Astelin. • Review the list of medications that need to be avoided below. Antihistamines to stop 10 days prior to testing: Generic Brand Name Acrivastine Semprex Azatadine Optimine, Trinalin Bropheniramine AccuHist, Bromfed, -
Pharmaceuticals As Environmental Contaminants
PharmaceuticalsPharmaceuticals asas EnvironmentalEnvironmental Contaminants:Contaminants: anan OverviewOverview ofof thethe ScienceScience Christian G. Daughton, Ph.D. Chief, Environmental Chemistry Branch Environmental Sciences Division National Exposure Research Laboratory Office of Research and Development Environmental Protection Agency Las Vegas, Nevada 89119 [email protected] Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada Why and how do drugs contaminate the environment? What might it all mean? How do we prevent it? Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada This talk presents only a cursory overview of some of the many science issues surrounding the topic of pharmaceuticals as environmental contaminants Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada A Clarification We sometimes loosely (but incorrectly) refer to drugs, medicines, medications, or pharmaceuticals as being the substances that contaminant the environment. The actual environmental contaminants, however, are the active pharmaceutical ingredients – APIs. These terms are all often used interchangeably Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division, Las Vegas, Nevada Office of Research and Development Available: http://www.epa.gov/nerlesd1/chemistry/pharma/image/drawing.pdfNational