Florida International University FIU Digital Commons HWCOM Faculty Publications Herbert Wertheim College of Medicine 10-23-2019 Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis SP Singh Hitendra S. Chand S. Banerjee H. Agarwal V. Raizada See next page for additional authors Follow this and additional works at: https://digitalcommons.fiu.edu/com_facpub Part of the Medicine and Health Sciences Commons This work is brought to you for free and open access by the Herbert Wertheim College of Medicine at FIU Digital Commons. It has been accepted for inclusion in HWCOM Faculty Publications by an authorized administrator of FIU Digital Commons. For more information, please contact
[email protected]. Authors SP Singh, Hitendra S. Chand, S. Banerjee, H. Agarwal, V. Raizada, S. Roy, and M. Sopori Digestive Diseases and Sciences (2020) 65:141–149 https://doi.org/10.1007/s10620-019-05838-6 ORIGINAL ARTICLE Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis Shashi P. Singh1 · Hitendra S. Chand2 · Santanu Banerjee3 · Hemant Agarwal4 · Veena Raizada4 · Sabita Roy3 · Mohan Sopori1 Received: 30 March 2019 / Accepted: 10 September 2019 / Published online: 23 October 2019 © The Author(s) 2019 Abstract Background Ulcerative colitis (UC) is a Th2 infammatory bowel disease characterized by increased IL-5 and IL-13 expres- sion, eosinophilic/neutrophilic infltration, decreased mucus production, impaired epithelial barrier, and bacterial dysbiosis of the colon. Acetylcholine and nicotine stimulate mucus production and suppress Th2 infammation through nicotinic receptors in lungs but UC is rarely observed in smokers and the mechanism of the protection is unclear.