PROJECT FINAL REPORT Grant Agreement number: 305626 Project acronym: RADIANT Project title: Rapid development and distribution of statistical tools for high-throughput sequencing data Funding Scheme: Collaborative Project (FP7-HEALTH-2012-2.1.1-3: Statistical methods for collection and analysis of -omics data) Period covered: from 1.12.2013 to 30.11.2015 Name of the scientific representative of the project's co-ordinator1, Title and Organisation: Prof. Magnus Rattray. The University of Manchester Tel: 0161 275 5094 Fax: E-mail: Magnus.
[email protected] Project website address: http://radiant-project.eu 1 Usually the contact person of the coordinator as specified in Art. 8.1. of the Grant Agreement. 4.1 Final publishable summary report 4.1.1 Executive summary The objectives of the RADIANT project were to develop improved computational tools for the analysis of high-throughput sequencing (HTS) data, to rapidly disseminate these tools to the wider scientific community and to support practitioners in the application of these and other advanced HTS data analysis tools in their scientific applications, lowering the bar for the widespread adoption of cutting-edge statistical tools. The project has been successful in achieving these objectives. The RADIANT project supported the development of several superb data analysis tools which have been widely adopted by practitioners. The new DESeq2 tool for differential expression analysis was developed entirely through RADIANT funding and provides substantial improvements over the earlier DESeq tool; it is one of the most widely-used tools in genomics (Love et al., 2014 cited 228 times in Scopus, 34500 software downloads in the last year).