Premenstrual Syndrome and Menopause

Total Page:16

File Type:pdf, Size:1020Kb

Premenstrual Syndrome and Menopause Premenstrual syndrome and menopause 1 This booklet has been written by Dr Louise Newson, GP, menopause specialist and founder of the Newson Health and Wellbeing Centre in Stratford-upon-Avon, England. For more information on Dr Newson visit www.menopausedoctor.co.uk Contents Types of PMS . 4 Diagnosing PMS . 5 Impact, causes and symptoms of PMS . 5 Treatments for mild to moderate PMS . 7-9 Treatments for moderate to severe PMS . 9-10 PMS, perimenopause and menopause . 11 2 What is Premenstrual syndrome/PMS? Premenstrual syndrome (also known as PMS) is when women who have periods experience distressing symptoms in the days or even weeks leading up to starting their period. PMS encompasses a vast array of psychological symptoms such as depression, anxiety, irritability, loss of confidence and mood swings. There are also physical symptoms, such as bloatedness and breast tenderness. PMS is identified when symptoms occur - and have a negative impact - during the luteal phase of your menstrual cycle. The luteal phase occurs between ovulation (normally mid- cycle, around day 14) and starting your period (usually around day 28). Although the average length of the menstrual cycle is 28 days, it can vary greatly between women and you may find the length of your cycle varies from month to month. 3 Types of PMS Many women notice their premenstrual luteal phase and improve when you start symptoms, but they are not really affected your period. You should then have a by them in any significant way. This would symptom-free week after your period. not be considered as a premenstrual disorder as such, merely a typical Variant PMDs physiological process. Unfortunately, for There are also PMDs that do not meet many other women the symptoms that the criteria for core PMDs. These are occur in the premenstrual part of their called ‘variant’ PMDs and examples of cycles do have a negative effect on their these include when you experience PMS lives and relationships. symptoms but do not have periods (for various medical reasons), when you have There are several types of premenstrual PMS symptoms that are triggered by disorders (PMD) and they are classified progestogen treatments or when you into two groups: ‘core’ premenstrual have an existing medical condition that is disorders and ‘variant’ premenstrual exacerbated in the premenstrual phase. disorders. The most commonly encountered and widely recognised types Premenstrual dysphoric disorder of PMS are the core premenstrual (PMDD) disorders. This term is becoming increasingly used and is an extreme version of a core Core PMDs premenstrual disorder; there are strict Women with premenstrual disorders criteria for diagnosing PMDD. Certain have symptoms that are severe enough to symptoms must be present, and this affect daily functioning, interfere with always includes mood. The symptoms work, school performance or must occur in the luteal phase and must interpersonal relationships. The symptoms be severe enough to disrupt daily occur and recur in ovulatory cycles. functioning. Symptoms must be present during the 4 Diagnosing PMS It is the timing of symptoms and the degree change over the course of a cycle (such as of impact on daily activity that supports a balance-app.com) diagnosis of PMS, rather than merely the types of symptoms themselves. Identifying Using such tools will accurately reflect what the timing of the symptoms is crucial as days symptoms occur, which days they are there are no blood tests to confirm PMS; absent, the days of menstruation and the keeping a symptom diary is the most duration of the menstrual cycle. It provides reliable method of diagnosis. You should your GP with an evidence base from which keep the diary over the length of two cycles to both diagnose and treat the PMS. This as a minimum and write in it as it happens information should be established and rather than relying on your memory a week shared with your GP before any treatment or two later. is commenced. There are charts or questionnaires If a symptom diary is inconclusive, there is developed for this purpose. The DRSP an alternative way of diagnosing PMS and tool (Daily Record of Severity of that is to ‘shut off’ the ovaries by using Problems) is a questionnaire that is medication. GnRH (gonadotropin releasing widely used by doctors; The National hormone) analogues are a group of drugs Association for Premenstrual Syndrome that are modified versions of a naturally (NAPS) has a chart that can be occurring hormone in the body, which help downloaded (www.pms.org.uk) and the to control the menstrual cycle. Shutting IAPMD also has a symptom tracker down the body’s production of estrogen (https://iapmd.org/symptom-tracker) to and progestogen for three months, by using record your symptoms over the month. a GnRH analogue, will stop the menstrual Alternatively, some women find using a cycle occurring and should in theory stop period tracking app useful for logging PMS symptoms. If symptoms do not stop symptoms and monitoring how they then other medical or psychiatric causes should be investigated. 5 Impact of PMS PMS can occur in any woman during her PMS can affect not only the individual child-bearing years. It is estimated that as woman but her whole network of many as 30% of women experience relationships – partners, children, relatives, moderate to severe PMS and 5-8% of friends and work colleagues. The these women suffer with very severe PMS fluctuating nature of symptoms can be or PMDD. This means that for 5 million unsettling for all involved. women in the UK, PMS is having a significant and detrimental effect on their quality of life, if left untreated. Causes of PMS Although the precise causes of PMS are by their hormones, postmenopause, and yet to be identified – there may be a time is often needed to find the right HRT genetic susceptibility for some women - regimen for these women). there is compelling evidence that symptoms are directly related to the PMS appears to begin, or increase in fluctuation of hormone levels in the severity, at times of marked hormonal monthly cycle. PMS is not seen in young change such as in puberty (even before girls who are yet to start their periods, in the first period happens), starting or pregnancy, or after the menopause in stopping the oral contraceptive pill, most women. (Women with a history of after pregnancy, and during the severe PMS/PMDD may still be affected perimenopause and menopause. Symptoms of PMS PMS is characterised by a number of Most women will experience only a few symptoms (over 150 have been identified) of these symptoms – one or two may be and they are usually grouped into dominant - and each symptom can vary psychological and behavioural, and physical in severity during a cycle, and from one symptoms. cycle to another. New symptoms may present at any time during a woman’s Common psychological and behavioural experience of PMS. symptoms are mood swings, depression, tiredness, fatigue or lethargy, anxiety, PMS symptoms may be experienced feeling out of control, irritability, aggression, continuously from ovulation to anger, disordered sleep, and food cravings. menstruation, for just the 7 days before menstruation, at ovulation for 3 or 4 days, Common physical symptoms are and/or just prior to menstruation. Some breast tenderness (mastalgia), bloating, women do not experience relief from clumsiness, and headaches. symptoms until the day of the period’s heaviest flow. 6 Treatments for PMS Treatments for mild to moderate PMS There are different levels of management weight gain. Changing to carbohydrates for PMS, depending on the severity of that releases glucose more slowly (low symptoms and how a woman has glycaemic index/GI carbohydrates) such as responded to previous treatments. The wholegrain bread, brown or basmati rice, first line approach most GPs will adopt is pulses, beans or sweet potatoes and having to try one or more of the following: plenty of low GI vegetables such as salad lifestyle changes and exercise, vitamin or greens, can be beneficial. Avoiding meat B6 supplements, the combined oral in the 7 - 10 days before your menstrual contraceptive pill, Cognitive Behavioural cycle may help to reduce the pain Therapy (CBT), and a low-dose SSRI associated with PMS. (antidepressant). The essential fats in oily fish, such as Lifestyle changes salmon, mackerel and sardines, or in Making healthy changes to your lifestyle can plant-based foods such as chia seeds, be beneficial if you experience milder PMS edamame, or kidney beans, may improve symptoms. This includes reducing stress, PMS symptoms. It is recommended that limiting alcohol and caffeine, and cutting you eat foods high in Omega 3 oils down or stopping smoking. Alcohol may two times a week or in the form of a contribute to anxiety symptoms and quality fish oil supplement or algae-based hormone imbalance - it is best consumed EPA/DHA. Green vegetables are rich in in moderation. High caffeine consumption fibre, magnesium and folic acid and are has been associated with an increased important for hormone balance, foods rich incidence of PMS, and it may make breast in B vitamins, particularly B1 and B2, such tenderness worse for some women. as cereals, legumes and nuts, and leafy Studies have shown that smokers are more vegetables can help with PMS symptoms. likely to develop PMS and the more severe Studies have also shown that women form, PMDD. whose diet is rich in calcium and vitamin D are less likely to suffer from PMS. In Important lifestyle changes also involve addition to dairy products, calcium can be improving your diet and getting the right found in green vegetables like cabbage, amount and type of exercise: kale and broccoli, as well as nuts and seeds, and vitamin D is made by the skin in Diet response to sunlight.
Recommended publications
  • Dental Considerations in Pregnancy and Menopause
    J Clin Exp Dent. 2011;3(2):e135-44. Pregnancy and menopause in dentistry. Journal section: Oral Medicine and Pathology doi:10.4317/jced.3.e135 Publication Types: Review Dental considerations in pregnancy and menopause Begonya Chaveli López, Mª Gracia Sarrión Pérez, Yolanda Jiménez Soriano Valencia University Medical and Dental School. Valencia (Spain) Correspondence: Apdo. de correos 24 46740 - Carcaixent (Valencia ), Spain E-mail: [email protected] Received: 01/07/2010 Accepted: 05/01/2011 Chaveli López B, Sarrión Pérez MG, Jiménez Soriano Y. Dental conside- rations in pregnancy and menopause. J Clin Exp Dent. 2011;3(2):e135-44. http://www.medicinaoral.com/odo/volumenes/v3i2/jcedv3i2p135.pdf Article Number: 50348 http://www.medicinaoral.com/odo/indice.htm © Medicina Oral S. L. C.I.F. B 96689336 - eISSN: 1989-5488 eMail: [email protected] Abstract The present study offers a literature review of the main oral complications observed in women during pregnancy and menopause, and describes the different dental management protocols used during these periods and during lac- tation, according to the scientific literature. To this effect, a PubMed-Medline search was made, using the following key word combinations: “pregnant and dentistry”, “lactation and dentistry”, “postmenopausal and dentistry”, “me- nopausal and dentistry” and “oral bisphosphonates and dentistry”. The search was limited to reviews, metaanalyses and clinical guides in dental journals published over the last 10 years in English and Spanish. A total of 38 publi- cations were evaluated. Pregnancy can be characterized by an increased prevalence of caries and dental erosions, worsening of pre-existing gingivitis, or the appearance of pyogenic granulomas, among other problems.
    [Show full text]
  • 6 Ways Your Brain Transforms During Menopause
    6 Ways Your Brain Transforms During Menopause By Aviva Patz Movies and TV shows have gotten a lot of laughs out of menopause, with its dramatic hot flashes and night sweats. But the midlife transition out of our reproductive years—marked by yo-yoing of hormones, mostly estrogen—is a serious quality-of-life issue for many women, and as we're now learning, may leave permanent marks on our health. "There is a critical window hypothesis in that what is done to treat the symptoms and risk factors during perimenopause predicts future health and symptoms," explains Diana Bitner, MD, assistant professor at Michigan State University College of Human Medicine and author of I Want to Age Like That: Healthy Aging Through Midlife and Menopause. "If women act on the mood changes in perimenopause and get healthy and take estrogen, the symptoms are much better immediately and also lifelong." (Going through menopause and your hormones are out of whack? Then check out The Hormone Reset Diet to balance your hormones and lose weight.) For many decades, the mantra has been that the only true menopausal symptoms are hot flashes and vaginal dryness. Certainly they're the easiest signs to spot! But we have estrogen receptors throughout the brain and body, so when estrogen levels change, we experience the repercussions all over—especially when it comes to how we think and feel. Two large studies, including one of the nation's longest longitudinal investigations, have revealed that there's a lot going on in the brain during this transition. "Before it was hard to tease out: How much of this is due to the ovaries aging and how much is due to the whole body aging?" says Pauline Maki, PhD, professor of psychiatry and psychology at the University of Illinois at Chicago and Immediate Past President of the North American Menopause Society (NAMS).
    [Show full text]
  • Luteal Phase Deficiency: What We Now Know
    ■ OBGMANAGEMENT BY LAWRENCE ENGMAN, MD, and ANTHONY A. LUCIANO, MD Luteal phase deficiency: What we now know Disagreement about the cause, true incidence, and diagnostic criteria of this condition makes evaluation and management difficult. Here, 2 physicians dissect the data and offer an algorithm of assessment and treatment. espite scanty and controversial sup- difficult to definitively diagnose the deficien- porting evidence, evaluation of cy or determine its incidence. Further, while Dpatients with infertility or recurrent reasonable consensus exists that endometrial pregnancy loss for possible luteal phase defi- biopsy is the most reliable diagnostic tool, ciency (LPD) is firmly established in clinical concerns remain about its timing, repetition, practice. In this article, we examine the data and interpretation. and offer our perspective on the role of LPD in assessing and managing couples with A defect of corpus luteum reproductive disorders (FIGURE 1). progesterone output? PD is defined as endometrial histology Many areas of controversy Linconsistent with the chronological date of lthough observational and retrospective the menstrual cycle, based on the woman’s Astudies have reported a higher incidence of LPD in women with infertility and recurrent KEY POINTS 1-4 pregnancy losses than in fertile controls, no ■ Luteal phase deficiency (LPD), defined as prospective study has confirmed these find- endometrial histology inconsistent with the ings. Furthermore, studies have failed to con- chronological date of the menstrual cycle, may be firm the superiority of any particular therapy. caused by deficient progesterone secretion from the corpus luteum or failure of the endometrium Once considered an important cause of to respond appropriately to ovarian steroids.
    [Show full text]
  • Relation of Cardiovascular Risk Factors in Women Approaching Menopause
    University of Massachusetts Medical School eScholarship@UMMS Women’s Health Research Faculty Publications Women's Faculty Committee 2006-02-24 Relation of cardiovascular risk factors in women approaching menopause to menstrual cycle characteristics and reproductive hormones in the follicular and luteal phases Karen A. Matthews Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/wfc_pp Part of the Cardiology Commons, Obstetrics and Gynecology Commons, and the Preventive Medicine Commons Repository Citation Matthews KA, Santoro N, Lasley WL, Chang Y, Crawford SL, Pasternak RC, Sutton-Tyrrell K, Sowers M. (2006). Relation of cardiovascular risk factors in women approaching menopause to menstrual cycle characteristics and reproductive hormones in the follicular and luteal phases. Women’s Health Research Faculty Publications. https://doi.org/10.1210/jc.2005-1057. Retrieved from https://escholarship.umassmed.edu/wfc_pp/43 This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Women’s Health Research Faculty Publications by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. Cardiovascular Risk Factors 1 Are the Cardiovascular Risk Factors of Women Approaching Menopause associated with Menstrual Cycle Characteristics and Reproductive Hormones in the Follicular and Luteal Phase?: Study of Women’s Health Across the Nation Daily Hormone Study Karen A. Matthews, PhD. 1 Nanette Santoro, MD 2, Bill Lasley, PhD. 3, Yuefang Chang, PhD. 4, Sybil Crawford, PhD. 5, Richard C. Pasternak, MD 6, Kim Sutton-Tyrrell, DrPH 4, and Mary Fran Sowers, PhD. 7 1 Departments of Psychiatry, Epidemiology and Psychology, University of Pittsburgh, Pittsburgh, PA.
    [Show full text]
  • Endocrine Control of Lactational Infertility. I
    Maternal Nutrition and Lactational Infertility, edited by I. Dobbing. Nestld Nutrition, Vevey/ Raven Press, New York © 1985. Endocrine Control of Lactational Infertility. I *Alan S. McNeilly, *Anna Glasier, and fPeter W. Howie *MRC Reproductive Biology Unit, Edinburgh EH3 9EW, and 1'Department of Obstetrics and Gynaecology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 951, Scotland Although there is no doubt that breastfeeding suppresses ovarian activity, the reasons for the immense variability in the duration of this suppression and the mechanisms by which the suckling stimulus causes it remain unclear. The interbirth interval in women who breastfeed can be divided into three main components: (a) the period of lactational amenorrhoea, (b) a period when menstruation returns either during or after lactation, and (c) pregnancy. The length of periods a and b will vary considerably depending on the pattern of breastfeeding, and in a few cases pregnancy will occur during the period of lactational amenorrhoea without an intervening period of menstrual cycles. In an attempt to clarify the mechanisms controlling each of periods a and b above, the changes in endocrine and ovarian activities will be explored. GONADOTROPHIC CONTROL OF THE MENSTRUAL CYCLE Before discussing in detail the influences of suckling on ovarian activity, it is first necessary to outline the basic mechanisms controlling the growth and devel- opment of follicles and subsequent formation of the corpus luteum in the normal menstrual cycle. The basic changes in the four principal hormones involved are shown in Fig. 1. At the time of menses following the demise of the corpus luteum of the previous cycle, follicle development starts, and usually a single follicle begins to grow.
    [Show full text]
  • Variability in the Length of Menstrual Cycles Within and Between Women - a Review of the Evidence Key Points
    Variability in the Length of Menstrual Cycles Within and Between Women - A Review of the Evidence Key Points • Mean cycle length ranges from 27.3 to 30.1 days between ages 20 and 40 years, follicular phase length is 13-15 days, and luteal phase length is less variable and averages 13-14 days1-3 • Menstrual cycle lengths vary most widely just after menarche and just before menopause primarily as cycles are anovulatory 1 • Mean length of follicular phase declines with age3,11 while luteal phase remains constant to menopause8 • The variability in menstrual cycle length is attributable to follicular phase length1,11 Introduction Follicular and luteal phase lengths Menstrual cycles are the re-occurring physiological – variability of menstrual cycle changes that happen in women of reproductive age. Menstrual cycles are counted from the first day of attributable to follicular phase menstrual flow and last until the day before the next onset of menses. It is generally assumed that the menstrual cycle lasts for 28 days, and this assumption Key Points is typically applied when dating pregnancy. However, there is variability between and within women with regard to the length of the menstrual cycle throughout • Follicular phase length averages 1,11,12 life. A woman who experiences variations of less than 8 13-15 days days between her longest and shortest cycle is considered normal. Irregular cycles are generally • Luteal phase length averages defined as having 8 to 20 days variation in length of 13-14 days1-3 cycle, whereas over 21 days variation in total cycle length is considered very irregular.
    [Show full text]
  • Infertility Investigations for Women
    Infertility investigations for women Brooke Building Gynaecology Department 0161 206 5224 © G21031001W. Design Services, Salford Royal NHS Foundation Trust, All Rights Reserved 2021. Document for issue as handout. Unique Identifier: SURG08(21). Review date: May 2023. This booklet is aimed for women undergoing fertility LH (Luteinising Hormone) Progesterone investigations. Its’ aim is to Oligomenorrhoea - When the provide you with some useful periods are occurring three In women, luteinising hormone Progesterone is a female information regarding your or four times a year (LH) is linked to ovarian hormone produced by the hormone production and egg ovaries after ovulation. It investigations. Irregular cycle - Periods that maturation. LH is used to causes the endometrial lining vary in length We hope you !nd this booklet measure a woman’s ovarian of the uterus to get thicker, helpful. The following blood tests are reserve (egg supply). making it receptive for a used to investigate whether You will be advised to have some It causes the follicles to grow, fertilised egg. ovulation (production of an egg) or all of the following tests: mature and release the eggs Progesterone levels increase is occurring each month and also for fertilisation. It reaches its after ovulation, reaching a to help determine which fertility Hormone blood tests highest level (the LH surge) in maximum level seven days treatments to offer. Follicular bloods tests the middle of the menstrual before the start of the next cycle 48 hours prior to ovulation period. The progesterone test is These routine blood tests are FSH (Follicle Stimulating i.e. days 12-14 of a 28 day cycle.
    [Show full text]
  • The Evolutionary Ecology of Age at Natural Menopause
    1 The Evolutionary Ecology of Age at Natural 2 Menopause: Implications for Public Health 3 4 Abigail Fraser1,3, Cathy Johnman1, Elise Whitley1, Alexandra Alvergne2,3,4 5 6 7 1 Institute of Health and Wellbeing, University of Glasgow, UK 8 2 ISEM, Université de Montpellier, CNRS, IRD, EPHE, Montpellier, France 9 3 School of Anthropology & Museum Ethnography, University of Oxford, UK 10 4 Harris Manchester College, University of Oxford, UK 11 12 13 14 15 16 17 18 19 Author for correspondence: 20 [email protected] 21 22 23 Word count: 24 Illustrations: 2 boxes; 3 figures; 1 table 25 26 27 Key words: reproductive cessation, life-history, biocultural, somatic ageing, age at 28 menopause, ovarian ageing. 29 1 30 31 Abstract 32 33 Evolutionary perspectives on menopause have focused on explaining why early 34 reproductive cessation in females has emerged and why it is rare throughout the 35 animal kingdom, but less attention has been given to exploring patterns of diversity in 36 age at natural menopause. In this paper, we aim to generate new hypotheses for 37 understanding human patterns of diversity in this trait, defined as age at final menstrual 38 period. To do so, we develop a multi-level, inter-disciplinary framework, combining 39 proximate, physiological understandings of ovarian ageing with ultimate, evolutionary 40 perspectives on ageing. We begin by reviewing known patterns of diversity in age at 41 natural menopause in humans, and highlight issues in how menopause is currently 42 defined and measured. Second, we consider together ultimate explanations of 43 menopause timing and proximate understandings of ovarian ageing.
    [Show full text]
  • Trends and Patterns in Menarche in the United States: 1995 Through 2013–2017 by Gladys M
    National Health Statistics Reports Number 146 September 10, 2020 Trends and Patterns in Menarche in the United States: 1995 through 2013–2017 By Gladys M. Martinez, Ph.D. Abstract older, have older friends, and be more likely to engage in negative behaviors Objective—This report presents national estimates of age at first menstrual period such as missing school, smoking, and for women aged 15–44 in the United States in 2013–2017 based on data from the drinking (8–11). The younger the age at National Survey of Family Growth (NSFG). Estimates for 2013–2017 are compared first menstrual period and first sexual with those from previous NSFG survey periods (1995, 2002, and 2006–2010). intercourse, the longer the interval Methods—Data for all survey periods analyzed are based on in-person interviews young women will potentially spend at with nationally representative samples of women in the household population aged risk of pregnancy. Differences in age at 15–44 in the United States. For the 2013–2017 survey period, interviews were menarche across population subgroups conducted with 10,590 female respondents aged 15–44. In 2015–2017, the age range may help explain differences in timing of the NSFG included women aged 15–49, but only those aged 15–44 were included of first sexual intercourse and timing of in this analysis. The response rate for the 2013–2017 NSFG was 67.4% for women. first births. The relationship between age Measures of menarche in this report include average age at first menstrual period, at menarche and the timing of first sexual probability of first menstrual period at each age, and the relationship between age at intercourse in the United States has menarche and age at first sexual intercourse.
    [Show full text]
  • Changes Before the Change1.06 MB
    Changes before the Change Perimenopausal bleeding Although some women may abruptly stop having periods leading up to the menopause, many will notice changes in patterns and irregular bleeding. Whilst this can be a natural phase in your life, it may be important to see your healthcare professional to rule out other health conditions if other worrying symptoms occur. For further information visit www.imsociety.org International Menopause Society, PO Box 751, Cornwall TR2 4WD Tel: +44 01726 884 221 Email: [email protected] Changes before the Change Perimenopausal bleeding What is menopause? Strictly defined, menopause is the last menstrual period. It defines the end of a woman’s reproductive years as her ovaries run out of eggs. Now the cells in the ovary are producing less and less hormones and menstruation eventually stops. What is perimenopause? On average, the perimenopause can last one to four years. It is the period of time preceding and just after the menopause itself. In industrialized countries, the median age of onset of the perimenopause is 47.5 years. However, this is highly variable. It is important to note that menopause itself occurs on average at age 51 and can occur between ages 45 to 55. Actually the time to one’s last menstrual period is defined as the perimenopausal transition. Often the transition can even last longer, five to seven years. What hormonal changes occur during the perimenopause? When a woman cycles, she produces two major hormones, Estrogen and Progesterone. Both of these hormones come from the cells surrounding the eggs. Estrogen is needed for the uterine lining to grow and Progesterone is produced when the egg is released at ovulation.
    [Show full text]
  • Association Between Increased Expression of Endothelial Isoform of Nitric Oxide Synthase in the Human Fallopian Tube and Tubal Ectopic Pregnancy
    Iran J Reprod Med Vol. 12. No. 1. pp: 19-28, January 2014 Original article Association between increased expression of endothelial isoform of nitric oxide synthase in the human fallopian tube and tubal ectopic pregnancy Leyla Fath Bayati1 M.Sc., Marefat Ghaffari Novin1, 2 M.D., Ph.D., Fatemeh Fadaei Fathabadi1 Ph.D., Abbas Piryaei1 Ph.D., Mohammad Hasan Heidari1 Ph.D., Mozhgan Bandehpour2 Ph.D., Mohsen Norouzian1 Ph.D., Mahdi Alizadeh Parhizgar3 M.D., Mahmood Shakooriyan Fard3 B.Sc. 1. Department of Biology and Abstract Anatomical Sciences, Faculty of Medicine, Shahid Beheshti Background: Tubal ectopic pregnancy (tEP) is the most common type of extra- University of Medical Sciences, uterine pregnancy and the most common cause of maternal mortality. Nitric oxide Tehran, Iran. (NO) is a molecule that incorporates in many physiological processes of female 2. Cellular and Molecular Biology reproductive system. Recent studies have demonstrated the possible role of Research Center, Shahid Beheshti University of Medical endothelial isoform of nitric oxide synthase (eNOS) enzyme in the regulation of Sciences, Tehran, Iran. many reproductive events that occur in the fallopian tube (FT). 3. Department of Pathology, Objective: The aim of this study was to evaluate the expression of eNOS in the FTs Kamkar Arab-Niya Hospital, of women with tEP. Qom University of Medical Sciences, Qom, Iran. Materials and Methods: In this case-control study, a total number of 30FTs samples were obtained from three groups including: 10 FTs of women that bearing an EP, 10 FTs from the non-pregnant women at luteal phase of the menstrual cycle, and 10 FTs of healthy pregnant women (n=10).
    [Show full text]
  • Implantation of the Human Embryo
    14 Implantation of the Human Embryo Russell A. Foulk University of Nevada, School of Medicine USA 1. Introduction Implantation is the final frontier to embryogenesis and successful pregnancy. Over the past three decades, there have been tremendous advances in the understanding of human embryo development. Since the advent of In Vitro Fertilization, the embryo has been readily available to study outside the body. Indeed, the study has led to much advancement in embryonic stem cell derivation. Unfortunately, it is not so easy to evaluate the steps of implantation since the uterus cannot be accessed by most research tools. This has limited our understanding of early implantation. Both the physiological and pathological mechanisms of implantation occur largely unseen. The heterogeneity of these processes between species also limits our ability to develop appropriate animal models to study. In humans, there is a precise coordinated timeline in which pregnancy can occur in the uterus, the so called “window of implantation”. However, in many cases implantation does not occur despite optimal timing and embryo quality. It is very frustrating to both a patient and her clinician to transfer a beautiful embryo into a prepared uterus only to have it fail to implant. This chapter will review the mechanisms of human embryo implantation and discuss some reasons why it fails to occur. 2. Phases of human embryo implantation The human embryo enters the uterine cavity approximately 4 to 5 days post fertilization. After passing down the fallopian tube or an embryo transfer catheter, the embryo is moved within the uterine lumen by rhythmic myometrial contractions until it can physically attach itself to the endometrial epithelium.
    [Show full text]