Endovascular Pharmacology Chart

Drug Name Trade Names Manufacturer Drug Type Primary Use Mechanism Inhibits Clotting of Heparin (many) N/A Anticoagulant Stroke Prevention Blood In Vivo via Action on Antithrombin III

Enoxaparin Sodium Antithombotic or Clot- Intrinsic Cascade (low-molecular-weight Lovenox Aventis Anticoagulant Preventing Inhibition heparin [LMWH])

Fondaparinux Sodium Arixtra GlaxoSmithKline Anticoagulant Deep Vein Thrombosis Factor Xa Inhibition

Heparin Substitute for Direct Thrombin Bivalirudin Angiomax The Medicines Company Anticoagulant Heparin-Intolerant Inhibition Patients Heparin Substitute for Direct Thrombin Lepirudin Refludan Berlex Anticoagulant Heparin-Intolerant Inhibition Patients

GlaxoSmithKline/Texas Heparin-Induced Direct Thrombin Argatroban Argatroban Anticoagulant Biotechnology Corporation Thrombocytopenia Inhibition

Unstable Angina or Dalteparin Sodium Fragmin Pfizer LMWH Non-Q-Wave Factor Xa Inhibition Injection Myocardial Infarction

Stroke Prevention, Reduces the Ability of Myocardial Infarction, the Liver to Use Vitamin Warfarin Coumadin Bristol Myers Squibb Anticoagulant Deep Vein Thrombosis, K to Make Blood Other Clot Problems Clotting Proteins

Acetylsalicylic Acid, ASA Aspirin Bayer Antiplatelet Stroke Prevention Thromboxane Inhibitor

Inhibitor of Adenosine Clopidogrel Plavix Bristol Myers Squibb-Sanofi Antiplatelet Stroke Prevention Diphosphate-Mediated Platelet Aggregation

Boehringer Ingelheim Stimulates Prostacycline Dipyridamole Aggrenox, Persantine Antiplatelet Stroke Prevention Pharmaceuticals Production

Stimulates Prostacycline Ticlopindine Ticlid Roche Pharmaceuticals Antiplatelet Stroke Prevention Production

Chimeric Monoclonal Abciximab ReoPro Lilly/Centocor IIb/IIIa Inhibitor Cardiac Ischemia Antibody

Tyrosine Derivative That Merck or Guilford Acute Coronary Trofiban Aggrastat IIb/IIIa Inhibitor Fits Into RGD Sequence Pharmaceuticals Syndrome of GP IIb/IIIa

Millennium Pharmaceuticals, Cyclic Heptapeptide Acute Coronary Eptifibatide Integrelin Inc., and Schering-Plough IIb/IIIa Inhibitor That Fits Into RGD Syndrome Corporation Sequence of GP IIb/IIIa

62 I ENDOVASCULAR TODAY I APRIL 2005 Drug Name Trade Names Manufacturer Drug Type Primary Use Mechanism HMG CoA Reductase Atorvastatin Lipitor Pfizer Statin Lowering Cholesterol Inhibitor HMG CoA Reductase Fluvastatin Lescol Novartis Statin Lowering Cholesterol Inhibitor Mevacor Merck HMG CoA Reductase Lovastatin Statin Lowering Cholesterol Altocor Andrx Inhibitor HMG CoA Reductase Rosuvastatin Calcium Crestor AstraZeneca Statin Lowering Cholesterol Inhibitor

HMG CoA Reductase Pravastatin Sodium Pravachol Bristol Myers Squibb Statin Heart Disease Inhibitor

HMG CoA Reductase Simvastatin Zocor Merck Statin High Triglyceride Levels Inhibitor

Combination Product Containing HMG CoA Combination of Statin Simvastatin/Ezetimibe Vytorin Merck/Schering-Plough Hypercholesterolemia Reductase Inhibitor + and Zetia Calcium-Channel Antagonist

Combination product Combination of a Containing HMG CoA Amlodipine/Atorvastatin Caduet Pfizer Calcium-Channel Hypertension/Angina Reductase Inhibitor + Blocker With a Statin Calcium-Channel Antagonist

Thromboembolic Streptokinase Streptase Aventis Fibrinolytic Plasminogen Activator Disorders

Thromboembolic Tissue Plasminogen Alteplase Activase Genentech Fibrinolytic Disorders Activator

Consists of the Lysform Roberts Pharmaceuticals Acute Myocardial Anistreplase Eminase Fibrinolytic of Plasminogen and Corporation Infarction Streptokinase

Thromboembolic Converts Plasminogen to Urokinase Abbokinase Abbott Laboratories Fibrinolytic Disorders Plasmin

Recombinant Tissue Acute Myocardial Tenecteplase TNKase Genentech Fibrinolytic Plasminogen Activator Infarction (re-PA)

Proteolytically Peripheral Arterial Alfimeprase* Nuvelo Fibrinolytic Cleaves Both and Occlusion α β Chains of Fibrin

Acute Myocardial Converts Plasminogen to Reteplase Retevase Scios Fibrinolytic Infarction Plasmin

Reduced Cholesterol Ezetimibe Zetia Merck Lipid Lowering Lowering Cholesterol Absorpton From Gut

Dihydropyridine Calcium-Channel Nicardipine Hydrochloride Cardene I.V. EST Pharma Antihypertension Calcium-Channel Blocker Blocker

*Currently in phase III clinical trials. APRIL 2005 I ENDOVASCULAR TODAY I 63