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Cabotegravir Injection Is Nine Times More Superior to Oral Truvada for HIV Prevention

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Cabotegravir Injection Is Nine Times More Superior to Oral Truvada for HIV Prevention FOURTH QUARTER OCTOBER - DECEMBER 2020 HPTN 084 EXCITES Cabotegravir injection is nine times more superior to oral truvada for HIV prevention HPTN 084 protocol co-chair Prof. Mina Hosseinipour and some HPTN 084 team members during a press briefing held on November 11 2020. esearchers from the HIV Prevention important for HIV prevention in women as they Trials Network (HPTN) announced on could have a potentially discrete method to use. RNovember 9, 2020 data from the HPTN “Because it’s (cabotegravir) an injection, they 084 clinical trial indicated that a pre-exposure can do this without necessarily engaging their prophylaxis (PrEP) regimen of long-acting partner; they can make independent decions. cabotegravir (CAB LA) injections once every There is no pill they have to store, which might eight weeks was safe and superior to daily oral be concerning to them, and they don’t have to tenofovir/emtricitabine (FTC/TDF) for HIV remember to take the pill everyday,” she said, prevention among cisgender women in sub- adding that the injectable could really make life Saharan Africa. easy for women. The HPTN 084 study was done in She said in the two arms of the study for 20 sites in 7 countries in Sub-Saharan cabotegravir injection and Truvada pills, those Africa namely: Malawi, Botswana, taking pills had a little bit more gastrointestinal Eswatini, Kenya, South Africa, upset and nausea than those receiving the Uganda and Zimbabwe. injection. Those receiving the injection further had In Malawi the study was done some site reactions like pain and tenderness. in Lilongwe by UNC Project and Commenting on the study results research in Blantyre by the John Hopkins medical officer for the HPTN 084 study at UNC Research Project. 111 and 113 Project-Malawi, Dr. Thandie Lungu Mabedi participants were enrolled described the results as worth celebrating. Some of the in Lilongwe and Blantyre, “The results are revolutionary, special thanks media members respectively. to our study participants and the research team for during the Prof. Mina Hosseinipour, HPTN taking part in this transformative discovery in HIV briefing. 084 protocol co-chair, professor prevention amongst women.” Photos: Callisto Sekeleza of medicine at the University of North Carolina (UNC) at Chapel UNC Project recently made five presentations in Hill School of Medicine and a virtual meeting - 14th International Conference Scientific Director of UNC Project- on HIV Treatment, Pathogenesis and prevention Malawi told local press that Research in Resource-Limited Settings: (INTEREST results from the study were really 2020) held from 30 November - 4 December 2020. Fleming Fund: Mulanje shines in Grateful parents Bacteriology integrating depression of Charlie Scholars 2 laboratory staff 3 services into the NCD 7 speak. oriented Clinic 12 TIDZIWE POST FOURTH QUARTER 2020 Five presentations from UNC Project at INTEREST 2020 UNC Project recently made five presentations in a virtual meeting - 14th International Conference on HIV Treatment, Pathogenesis and prevention Research in Resource- Limited Settings (INTEREST 2020) held from 30 November - 4 December 2020. The annual INTEREST Conference is the premier scientific conference for HIV in Africa and brings together scientists involved in HIV treatment, pathogenesis, and prevention research from around the world. The conference showcases cutting-edge knowledge in the diagnosis and treatment of HIV Facilitators and participants on 20 October 2020 during a bacteriology SOP training at Mponela. and the prevention of the HIV- 1 infection. It also aims to foster building a community of African physicians and scientists to facilitate the implementation of local Fleming Fund Country Grant solutions for the management of patients living with HIV-1 infection and for the prevention of HIV Bacteriology laboratory staff oriented transmission. The five presentations made aboratory staff doing not put into practice, goes down the during the virtual conference were: microbiology under Fleming drain fast,” he said. 1. Early Experiences of Switching Project Fund national grant on anti- Speaking during the same event, Manager to Dolutegravir in Women Enrolled L microbial resistance in humans and Dr. Joseph Nkhoma, desk officer Gerald in Option B+, Malawi, presented by animals were advised to put into for antimicrobial resistance in the Tegha Allan Jumbe. practice lessons they learnt during department of animal health, also presenting 2. Maternal Tenofovir Exposure during the in Pregnancy and Risk of Preterm a series of workshops held in the advised the participants to follow the September Delivery Among Women Living months of September and October at SOPS and save time. training. with HIV in Malawi presented by Mponela in Dowa. “Let’s remind each other the Friday Saidi. Speaking during one of the right way of doing things. If we 3. Pregnant Women at Higher bacteriology standard operating don’t collect the right samples (for Risk of Hepatotoxicity When procedure (SOP) workshops held bacteriology tests), the results will Initiating TDF/3TC/EFV in Malawi from 19 to 23 October 2020, Dr. also not be right,” he said. presented by Emmanuel Singogo Danny Chinombo from Lilongwe The training tackled the 4. Test and Treat, The Dilemma of University of Agriculture and following topics, among others: the Woman in Antenatal Care in Natural Resources (Luanar) said culture protocols, identification of Malawi presented by Jennifer Tseka they were interested in three main organisms, anti-biotic mechanisms 5. Pooling Sputum Samples for GeneXpert Tb Testing in HIV types of bacteria. He added that it of resistance, antimicrobial Positive Women in Lilongwe, was a concern that poultry and daily susceptibility testing, introduction Malawi: A Cost-Saving Method animals received more antibiotics to to new culture protocols, storage of presented by Jonathan Majamanda. fight bacteria. isolates, inventory management and He advised the participants to introduction to database software take the lessons they would get from for management and analysis of the session seriously. microbiology laboratory data. “Anything which is learned but is This is an in-house publication. Its mission is to promote a sense of community by communicating information relevant and vital to the operations and staff of UNC Project Malawi. In a drive to increase participation and bring variety to the publication, all UNC Project staff are free and encouraged to contribute articles in this publication. Write ups are welcome in the range 400 – 600 words for event stories and a maximum of 1000 words for other more technical issues worth sharing. Forward your contributions to: [email protected] Graphic layout: COMMUNICATIONS Facilitators and participants on 29 September 2020 during a similar meeting. TIDZIWE POST FOURTH QUARTER 2020 13 Mulanje shines in integrating depression services into the NCD Clinic A photo occassion for the review meeting participants. Below: A representative from Mulanje shows the gitt. ulanje District Hospital implemented for their perseverance The five-year project is was on Friday 23 October especially when there was a general operational in ten health facilities M2020 recognized by UNC slowdown of activities in many in Karonga, Chilumba, Kasungu, Project-Malawi for its outstanding sectors because of the COVID-19 Salima, Mchinji, Lilongwe, role in integrating depression pandemic. Machinga, Phalombe, Zomba and services at their non-communicable “It’s not easy to do your work Mulanje. diseases (NCD) clinic. under these circumstances,” he said. The study is This came under the Sub- Deputy Director of Clinical sponsored by the Saharan Africa Regional Partnership Services responsible for NCDs in the (SHARP) for Mental Health Ministry of Health Dr. Jones Masiye National Institute Capacity Building programme being also highlighted that there was need of Mental Health implemented in Malawi by UNC to lace up integration of depression (NIMH) at the Project under the title ‘A Clinic- into the NCD programmes. National Randomized Trial of Strategies “Literature is telling us that in a Institutes of to Integrate Depression Care in few years to come, many diseases Health (NIH) Malawi’. will have vaccines while the NCDs The goal of The recognition was made will remain just like they are,” he the study during a review meeting held said and further commended those is to have at UNC Project Annex Building districts which were doing better data grounds and through an award of than others in the project. that can a certificate and a wall clock to be Receiving the recognition Brenda help the used by staff at their base. Nkhonjera of Mulanje District Ministry During the meeting UNC Hospital thanked the project Project-Malawi Country Director management for the recognition. of Health to come up with Innocent Mofolo commended “We will continue working an action plan to be used to integrate all the stakeholders from the hard and we will also work on our mental health services into non- districts where the project is being challenges,” she said. communicable diseases. In September UNC Project Laboratories installed GEORGE JOAKI RESEARCH CENTRE sequencing analyzers at the PCR laboratory at the George Joaki Research Centre at Area 18. The installation runs were successful. According to Illumina, manufacturer of the iSeq SET FOR DNA AND RNA SEQUENCING 100, one of the equipment to be used for sequencing, the system makes next-generation sequencing easier and more affordable than ever, allowing labs of all sizes to sequence DNA and RNA at the push of a button. The equipment will be used for a study that will generate important information about the etiology of possible serious bacterial infection (pSBI) and the epidemiology of bacterial anti-microbial resistance genes among young infants. Once aggregated into IDSeq (a global software platform that helps scientists identify pathogens in metagenomic sequencing data), it will allow for the comparison of resistance patterns between Malawi and other resource-limited settings. The machines were bought with funds from the Bill and Melinda Gates Foundation’s - Grand Challenge for a pilot study to support Anti-Microbial Resistance (AMR) activities in Malawi.
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