Parasitic Diseases of Dogs & Cats
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4/6/2017 Cairo University Faculty of Veterinary Medicine Department of Medicine and Infectious Diseases INFECTIOUS DISEASES OF DOGS AND CATS Course 453 2017 PARASITIC DISEASES OF DOGS & CATS Dr. Soliman Mohammed Soliman Hasan Lecturer of Infectious Diseases Dept. of Medicine and Infectious Diseases Faculty of Veterinary Medicine Cairo University 1 4/6/2017 Infectious Diseases of Dogs and Cats PARASITIC BACTERIAL VIRAL 1-Toxocariasis. 1- Canine brucellosis. 1- Rabies. 2- Dipylidiasis. 2- Kennel cough. 2- Canine Distemper. 3- Canine Babesiosis. 3- Leptosirosis. 3- Canine Parvovirus. 4- Canine Ehrilichiosis. 4- Feline leprosy. 4- Infectious canine hepatitis. 5- Ear mange. 5- Salmonellosis. 5- Cat Flu. 6- Red Mange. 6-Botulism. 6- Feline Infectious Peritonitis. 7- Sarcoptic Mange. 7-Feline Infectious anemia. 7- Feline Panleukopenia. 8- Isosporosis. 8- Feline Leukemia Virus. 9- Neosporosis. FUNGAL 10- Toxoplasmosis. 1-Ringworm. SYNDROME 11- Ticks. 2-Nasal Aspergillosis. 1- Fading Puppy syndrome. 12- Flea. 2- Fading Kitten Syndrome. 2 4/6/2017 CLASSIFICATION OF IMPORTANT PARASITIC DISEASES OF DOG AND CAT External Internal Blood Nematodes: Micro: Inside RBCs: Ascairs (Toxocara) Mite infestation. Babesia. Demodex, Sarcoptes and Cestodes: Psorptes. Dipylidium caninum Inside WBCs: Erlichia. Macro: Protozoa: 1- Tick infestation. 1- Toxoplasma. 2- Fleas. 2- Isospora (coccidia). 3- Lice infestation. 3- Neospora. ASCARIASIS (TOXOCARIASIS) 3 4/6/2017 Ascaris is a nematodal worm of small intestine affecting dog, cat (of zoonotic importance, visceral larval migrans) commonly occurs in puppies and kittens characterized by enlargement of abdomen with presence of adult worms in vomitus or faeces. Etiology • Toxocara canis infect dog and fox. • Toxocara cati infect cat and wild felidae. • Toxocara leonina infect dog, cat, fox, wild felidae and canidae. Mode of infection and Transmission 1. Ingestion of contaminated food or water with egg containing L2 2. In bitch: may reach fetus transplacental 3. Through milk (colostrum) Infective Stage .Egg containing embryo (L2) 4 4/6/2017 Life cycle (21-28 days) Adult worm in small intestine (puppies and adults) Eggs pass in feces Embryonated eggs (egg containing 2nd larval stage) in the environment Ingestion of contaminated food and water 2nd larval stage penetrate duodenal wall as 3rd stage Hepato-pulmonary migration (blood → liver → heart → lung) 3rd larval stage expelled with sputum and re-swallowed to reach small intestine and become mature which secrete eggs with faeces OR 2nd larval stage may migrate via placenta (transplacental infection) to infect fetuses or may pass to milk or colostrum to infect newly born pups 5 4/6/2017 Clinical signs 1. Progressive emaciation (with normal appetite) 2. Enlargement of abdomen "Pot belly" (worms that causes hypoproteinaemia and ascites) 3. Fever (due to pneumonia as secondary infection 39.5 – 40 °C) 4. Infected animals have alternating periods of diarrhea and constipation 5. Vomiting and Diarrhea (may contain snake like worms) 6. Icterus (obstructive jaundice if the adult obstructs the bile duce/ rarely hepatic jaundice if there is damage to liver tissue) => not a very common sign Clinical signs 7. Nervous signs (due to false migration of larva from heart to brain or accompanied the dead worms byproducts) 8. Rough coat (loose and dull) 9. A characteristic breath odor of acetone. 10.Coughing and nasal discharge 11.Fading puppy/ kitten syndrome (intestinal obstruction and pneumonia due to invading larvae that causes death during first few days of life) 12.Transplacental infection results in stillbirth due hepato- pulmonary and placental damage. 6 4/6/2017 Pot-belly (Ascaris Infested Puppy) Adult Worms Of Toxocara In Dog Stool 7 4/6/2017 PM Enteritis Snake like worm in small intestine Pneumonia Diagnosis • A history of weight loss, pot belly and presence of snake like worms in faeces or vomitus. • demonstration of characteristic ascaris egg in faeces by direct smear or concentration Floatation Technique as a circular, thick wall egg with single, large, opaque embryo 8 4/6/2017 Treatment Specific treatment: 1. Piprazine salts (drug of choice) orally. 2. Albendazole 3. Dorontal plus (contains Praziquantel active against cestodes as Dipylidium/ Pyrantel pamoate active against hookworms and ascaris and acts on the cholinergic receptors of the nematode resulting in spastic paralysis/ Febantel active against nematodes and blocks the parasite's energy metabolism, leading to energy exchange breakdown and inhibited glucose uptake) 1 tab/ 10 kg and repeated after 2 weeks 4. Revolution® pour on which is used on skin and effective against external parasites and round worms of dog and cat. 5. Bitches should be treated by daily dose of Fenbendazole as 25 mg/Kg for about 3 weeks before and 2 days after parturition. Also treatment of lactating bitch is recommended if puppies are infected. 6. Fluvermal syrup which interferes with the cellular tubulin formation in the worms leading to disturbance in the glucose uptake (dose of 3 days then repeated after 2 weeks). Symptomatic treatment: 1. Antibiotic (pneumonia) 2. Antipyretic (fever) 3. Laxative (after anthelmintic) 4. Vitamins and minerals 5. Tranquilizers in case of nervous manifestation. Control • Treat all puppies in range and the dam • Give prophylactic dose (periodical deworming) every 3 – 6 months and before pregnancy, parturition and weaning Public Health Importance . Visceral larval migrans: (Toxocara canis) . Human accidentally ingests the infective stage while playing with puppies and the signs differ according to the organ to which it migrates 9 4/6/2017 TAPEWORM INFECTIONS “DIPYLIDIASIS” It is a parasitic disease of dog, cat and man caused by cestode (tapeworm) called Dipylidium caninum, is transmitted by flea characterized clinically by diarrhea, emaciation, coilc, mild hyperesthesia with muscle twitching, convulsions and epileptiform fits occuring in heavy infestation. 10 4/6/2017 • Etiology: Dipylidium caninum • Final host: Dog and Cat • Intermediate host: Flea • Infective stage: Cysticercoid • Mode of infection: Ingestion of adult flea containing cysticercoid Life Cycle Adult worm in small intestine of final host ↓ Eggs pass out in feces (in gravid proglottids in egg capsule) ↓ Rupture of capsule and ingestion of egg by flea ↓ Eggs ingested by the flea, onchosphere is liberated after the ingestion of the eggs by intermediate host (Flea larva) so, Cysticercoid in the adult flea ↓ Ingestion of flea containing cysticercoids which mature to adult worm in small intestine 2-3 weeks post-infection 11 4/6/2017 Clinical signs 1. Infected dog become greedy in food 2. The coat become rough and the emaciation is present. 3. Diarrhea has been noted but subsides in a few days 4. Irritation in anal region due to passage of gravid proglottides lead to animal assumes the sitting position and draws its anus over the ground. 5. Fresh dried segments are frequently noted in stool or attached to the perianal region of infected dogs. 6. Irritation of the abdomen is sometimes apparent, is manifested in rolling or dragging over the ground, bite at the abdomen in an attempt to reduce the itching 7. Mild hyperesthesia with local muscles twitching and frequently paroxysms 8. Convulsions and epileptiform fits occuring particularly in heavy infestation 9. Vomiting may occur if the worm is abnormally present in the stomach. 10. It is usual to observe flea and or flea debris on skin of dog or cat infested by Dipylidium caninum. 11. Progressive emaciation due to flea bite as well as animals were off food. 12 4/6/2017 Dipylidium caninum PM Diagnosis • Enteritis • Visual detection of gravid segment in • Presence of tape worm (segmented 1/2 – stool 1 m) • Microscopic examination of gravid segment for demonstration of the egg nest or the egg packet. • Direct fecal exam • Concentration floatation technique. 13 4/6/2017 Dipylidium caninum Egg Nest 14 4/6/2017 Dipylidium caninum Treatment: • Anthelmintics for tapeworms infestations are Praziquantel compound (Distocide®) which is the drug of choice. • Not every drug that affects ascaris affects dipylidium) Control: • Eradication of flea from the place • Eradication of flea from the animal => revolution (cat) or diazenone (dog) or shampoo or Bars Public Health Importance: • Accidental ingestion of flea BABESIOSIS 15 4/6/2017 A tick transmitted disease characterized by high fever, red urine, jaundice and invasion and destruction of RBCs and acute hemolytic anemia • Etiology: 1- B. Canis (large babesia) 2- B. gibsoni (small babesia) • Inefctive Stage: Sporozoits 16 4/6/2017 Life cycle and epidemiology •Brown dog tick (Rhipicephalus sanguuineus and Haylomma species) •Infected blood transfusions. •Ticks acquire the infection by ingestion of blood from infected dogs. •Babesia reproduces sexually and asexually in ticks and there is trans-ovarian transmission. •The clinical disease is sporadic and its severity relate to age and immune status of the host. Young dogs are particularly susceptible. Clinical signs • Sub clinical and carrier dogs are common • There are 3 forms of the disease: 1. Per acute, 2. Acute and 3. Chronic 17 4/6/2017 Clinical signs 1- Peracute form • Sudden onset, shock and rapid death Clinical signs 2- Acute Form • High fever 41 °C, Anorexia, depressed. • Vomiting • Mucus membrane becomes congested (at fever stage) then pale and anaemic (destructed RBCs) then icteric with Jaundice and • Red urine • Enlargement of lymph nodes and spleen "Spleenomegaly" with oedema of the head and neck and