Anti-GGA3 Monoclonal Antibody, Clone FQS25451 (DCABH-6986) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-GGA3 monoclonal antibody, clone FQS25451 (DCABH-6986) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit monoclonal to GGA3 Antigen Description Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Immunogen Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human GGA3 aa 400-600. The exact sequence is proprietary.Database link: Q9NZ52 Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Rat, Human Clone FQS25451 Purity Tissue culture supernatant Conjugate Unconjugated Applications IHC-P, WB, Flow Cyt Positive Control SH-SY5Y, 293 and A431 cell lines; Human Infiltrating duct carcinoma of breast. Format Liquid Size 100 μl Buffer Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA, 59% PBS Preservative 0.01% Sodium Azide Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Ship Shipped at 4°C. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 [ Homo sapiens ] Official Symbol GGA3 Synonyms GGA3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; ADP-ribosylation factor-binding protein GGA3; KIAA0154; Golgi-localized, gamma ear-containing, ARF-binding protein 3; golgi associated, gamma adaptin ear containing, ARF binding Entrez Gene ID 23163 Protein Refseq NP_001166174 UniProt ID Q9NZ52 Chromosome Location 17q25 Pathway Arf1 pathway, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem. Function ADP-ribosylation factor binding; protein binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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Entrez ID 1 Symbol 1 Entrez ID 2 Symbol 2 Data Source (R
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Supporting Information
Supporting Information Friedman et al. 10.1073/pnas.0812446106 SI Results and Discussion intronic miR genes in these protein-coding genes. Because in General Phenotype of Dicer-PCKO Mice. Dicer-PCKO mice had many many cases the exact borders of the protein-coding genes are defects in additional to inner ear defects. Many of them died unknown, we searched for miR genes up to 10 kb from the around birth, and although they were born at a similar size to hosting-gene ends. Out of the 488 mouse miR genes included in their littermate heterozygote siblings, after a few weeks the miRBase release 12.0, 192 mouse miR genes were found as surviving mutants were smaller than their heterozygote siblings located inside (distance 0) or in the vicinity of the protein-coding (see Fig. 1A) and exhibited typical defects, which enabled their genes that are expressed in the P2 cochlear and vestibular SE identification even before genotyping, including typical alopecia (Table S2). Some coding genes include huge clusters of miRNAs (in particular on the nape of the neck), partially closed eyelids (e.g., Sfmbt2). Other genes listed in Table S2 as coding genes are [supporting information (SI) Fig. S1 A and C], eye defects, and actually predicted, as their transcript was detected in cells, but weakness of the rear legs that were twisted backwards (data not the predicted encoded protein has not been identified yet, and shown). However, while all of the mutant mice tested exhibited some of them may be noncoding RNAs. Only a single protein- similar deafness and stereocilia malformation in inner ear HCs, coding gene that is differentially expressed in the cochlear and other defects were variable in their severity.
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