The Legacy of Rebecca Lancefield

Total Page:16

File Type:pdf, Size:1020Kb

The Legacy of Rebecca Lancefield The Legacy of Rebecca Lancefield Serogrouping of Strep ome species of pneumoniae is easily streptococci are unique in distinguished from other S that they are classified or Streptococci by its alpha grouped according to the hemolysis, sensitivity to antigenic structure of their cell optochin, and solubility in bile. walls. Ever wondered how this was discovered? In this article The other major group of we will explore the history of streptococci, the beta-hemolytic how strep grouping came to be streps, are rather difficult to By Christopher Massey in common usage today. differentiate based on June, 2015 biochemical tests alone. They The genus Streptococcus all produce streptolysin, which contains many pathogens from is responsible for their ability to numerous body sites. Over 50 lyse blood cells, and can Christopher Massey is the species of these gram-positive typically be pathogenic to Research and Development cocci are currently recognized. humans and other animals. Manager at Hardy Diagnostics. From a clinical perspective, He earned his degree in Streptococcus species are microbiology at Cal Poly in separated into two major San Luis Obispo, California. groups: alpha- and beta- hemolytic for their characteristic HardyDiagnostics.com growth on Blood Agar plates. A well-known example of alpha-hemolytic Streptococcus is Streptococcus pneumoniae, which causes inflammatory conditions such as otitis media, Rapid Strep Grouping Kits, such as sinus infections and even StrepPRO, are a result of Dr. Lancefield’s meningitis or sepsis. Other diligent work in discovering the alpha-hemolytic streptococci serogroups of beta hemolytic strep. include the viridans streptococci, which are normally Originally termed Streptococcus commensal and rarely cause hemolyticus as a group, it was disease, with a notable apparent in the early 1900’s that exception being subacute these organisms warranted bacterial endocarditis. S. further classification. It was this realization that led Rebecca was offered a position at the “By the reaction of ‘agglutination,’ Lancefield to perform her Rockefeller Institute for four distinct immunological types and a certain number of groundbreaking work on Medical Research as a technical unclassifiable strains have been classifying these organisms into assistant in the lab of Dr. discovered among the 125 strains 18 categories that would later be Alphonse Dochez, who studied. Individuals of the same known as “Lancefield discovered that the common type are closely related to one Groupings.” These groupings cold was caused by a virus, and another immunologically, and the different types can be sharply provide the basis for Dr. Oswald Avery, one of the distinguished one from the other.” identification of these fathers of immunochemistry, potentially dangerous organisms and whose team discovered that The strains have been saved to that we use today. DNA is the molecule that this day and some became encodes genetic information. reference strains for Group A Rebecca Craighill Lancefield Lancefield remained at the streptococci in the Lancefield was born in Staten Island, New Rockefeller Institute (now the collection. York in 1895 to a colonel in the Rockefeller University) for 40 U.S. Army Corps of Engineers. years until she retired in 1965. Lancefield's work involved She spent her childhood preparing antigens by collecting travelling from city to city as Her early work focused on bacteria centrifuged from broth many children of military pneumococcus, but quickly cultures for 18 hours, and re- families often do. She originally shifted to research on the suspending them in an studied English at Wellesley various Streptococcus HCl/NaCl mixture. The mixture College in Massachusetts. hemolyticus outbreaks at was then heated, neutralized military facilities during World with NaOH and the precipitate War I. It was not known at the discarded. The resulting time whether the infections were supernatant would contain the due to a single virulent species, antigen mixture Lancefield used or the result of a group of for her precipitin tests. The distinct separate species antigen mixture could be previously categorized as one concentrated by using group. Lancefield’s work was consecutive overnight inspired by Dr. Avery’s earlier treatments of a sodium work using serological methods acetate/alcohol precipitation. to agglutinate and identify pneumococcus species. The antibodies Lancefield used were prepared by inoculating Within a year, Rebecca rabbits with heat-killed broth Lancefield’s diligent work cultures, followed by Sparked by an interest in a initially identified four distinct inoculation with live cultures. 6- zoology class, Lancefield serogroups of streptococci 8 weeks later, the rabbit serum changed her major and pursued which composed 70% of 125 was collected and could be used graduate work at Columbia initial strains under study. As a for agglutination tests. Because University in the field of co-author, she, Dr. Dochez and non-specific precipitin reactions bacteriology. Dr. Avery published their with antigens of heterologous landmark findings in the Journal strains mixed with the pure Upon obtaining her master’s of Experimental Medicine on serum, an adsorption treatment degree at Columbia, Lancefield June 1 of 1919. She concluded: was necessary. This involved mixing antigens of the was noticed that streptococci response of one serotype of S. heterologous strains with the from throat infections shared a pyogenes did not confer lasting inoculated rabbit serum and C carbohydrate that was protection to the more than 60 allowing the precipitin reaction serologically distinct from the C other known types of S. to occur, thus cleaning out any carbohydrate of streptococci pyogenes. non-specific antibodies as well isolated from bovine mastitis as any other agglutinating and both were distinct from By 1940, her work led to the factors in the serum. The result strains isolated from equine serological grouping of beta- was a clean serum that was strangles. It seemed that hemolytic streptococci known type-specific for the antigen of streptococcal disease and C as Lancefield’s groupings (A-H, the organism that the rabbit was carbohydrate type were L and M). Her contributions originally inoculated with. correlated. toward our understanding of These sera could be used to pathogenic streptococci are characterize unknown Four years of Lancefield’s work innumerable and have shaped Streptococci into serogroups. with the M protein and C the way we identify and treat carbohydrate culminated in streptococcal infections. In Lancefield later pursued her 1928 with the rapid publication addition, they provide the basis Ph.D at Columbia University on of seven papers in the Journal of for the epidemiological study of the study of viridans Experimental Medicine. streptococcal groups. streptococci and their possible Initially, the human strains of link to rheumatic fever. streptococci that shared a C Lancefield’s work contributed antigen were termed “Group A.” to discredit this link. Group B streptococci were initially isolated and classified From 1924-1928, Lancefield from bovine sources. Group C discovered two different types streptococci were isolated from of antigenic targets within an epizootic in guinea pigs. Streptococcus hemolyticus. One was the M protein, associated Starting in 1938, Dr. Lancefield with the ‘matte’ appearance of also was able to classify the colonies when grown on agar Group B Streptococci into Through and beyond World War and is related to virulence. “types” according to their II, Dr. Lancefield’s lab earned Streptococcus pyogenes capsular polysaccharides the name “The Scotland Yard of produces this protein, which is (similar to her work with Streptococcal Mysteries,” and associated with cross reactivity pneumococcus). Later, was sent thousands of strains of with heart muscle tissue, and is Lancefield was also able to streptococci for analysis and the true causative agent of show that white blood cells study. Dr. Lancefield’s team rheumatic fever. were unable to engulf bacteria diligently worked through these possessing M protein, thus strains and her work is still kept The other antigenic target initially evading the host’s in several volumes of Lancefield discovered was the C immune defense. Furthermore, notebooks, mostly written in her carbohydrate. It quickly became when M protein protection was own hand. Her bibliography apparent that the C carbohydrate overcome by specific comprises more than 50 could be used to distinguish antibodies, the antigenic publications over 60 years. between certain species of reaction was type-specific, streptococci. For example, it meaning that an immune Dr. Lancefield’s accolades include (but are not limited to) president of the Society of indoctrination and with most of egg/bourbon/rum mix. American Bacteriologists, his questions answered—as well Add the light cream with stirring. president of the American as with a collection of cultures Add the sugar to taste with mixing Association of Immunologists, of reference streptococcal (1 pound/batch), then add nutmeg recipient of the American Heart strains and samples of the to taste. Association Achievement relevant antisera.” She has been Award, election to the National a role model for young women Leave standing at least overnight with lid slightly ajar in refrigerator. Academy of Sciences, recipient considering a career in science. Serve after 2-3 weeks in the cold. of honorary degrees from Due to her success in the lab, Rockefeller University
Recommended publications
  • Oswald Avery and His Coworkers (Avery, Et Al
    1984 marks the fortieth anniversary of the publica- tion of the classic work of Oswald Avery and his coworkers (Avery, et al. 1944) proving that DNA is the hereditary molecule. Few biological discoveries rival that of Avery's. He paved the way for the many molecular biologists who followed. Indeed, 1944 is often cited as the beginning of molecular Oswald Avery biology. Having been briefed on the experiments a year before their publication, Sir MacFarlane Burnet and DNA wrote home to his wife that Avery "has just made an extremely exciting discovery which, put rather crudely, is nothing less than the isolation of a pure Charles L. Vigue gene in the form of desoxyribonucleic acid" (Olby 1974). Recalling Avery's discovery, Ernst Mayr said "the impact of Avery's finding was electrifying. I Downloaded from http://online.ucpress.edu/abt/article-pdf/46/4/207/41261/4447817.pdf by guest on 23 September 2021 can confirm this on the basis of my own personal experience . My friends and I were all convinced that it was now conclusively demonstrated that DNA was the genetic material" (Mayr 1982). Scientific dogma is established in many ways. Dis- coveries such as that of the planet Uranus are quickly accepted because the evidence for them is so compel- ling. Some scientific pronouncements are immedi- ately accepted but later found to be erroneous. For example, it was widely accepted in the 1930s, 1940s, and early 1950s that humans had 48 chromosomes; in 1956 it was proven that we have only 46. Some find- ings are not accepted even though, in retrospect, the evidence was compelling.
    [Show full text]
  • Martha Chase Dies
    PublisherInfo PublisherName : BioMed Central PublisherLocation : London PublisherImprintName : BioMed Central Martha Chase dies ArticleInfo ArticleID : 4830 ArticleDOI : 10.1186/gb-spotlight-20030820-01 ArticleCitationID : spotlight-20030820-01 ArticleSequenceNumber : 182 ArticleCategory : Research news ArticleFirstPage : 1 ArticleLastPage : 4 RegistrationDate : 2003–8–20 ArticleHistory : OnlineDate : 2003–8–20 ArticleCopyright : BioMed Central Ltd2003 ArticleGrants : ArticleContext : 130594411 Milly Dawson Email: [email protected] Martha Chase, renowned for her part in the pivotal "blender experiment," which firmly established DNA as the substance that transmits genetic information, died of pneumonia on August 8 in Lorain, Ohio. She was 75. In 1952, Chase participated in what came to be known as the Hershey-Chase experiment in her capacity as a laboratory assistant to Alfred D. Hershey. He won a Nobel Prize for his insights into the nature of viruses in 1969, along with Max Delbrück and Salvador Luria. Peter Sherwood, a spokesman for Cold Spring Harbor Laboratory, where the work took place, described the Hershey-Chase study as "one of the most simple and elegant experiments in the early days of the emerging field of molecular biology." "Her name would always be associated with that experiment, so she is some sort of monument," said her longtime friend Waclaw Szybalski, who met her when he joined Cold Spring Harbor Laboratory in 1951 and who is now a professor of oncology at the University of Wisconsin-Madison. Szybalski attended the first staff presentation of the Hershey-Chase experiment and was so impressed that he invited Chase for dinner and dancing the same evening. "I had an impression that she did not realize what an important piece of work that she did, but I think that I convinced her that evening," he said.
    [Show full text]
  • William Barry Wood, Jr
    NATIONAL ACADEMY OF SCIENCES W I L L I A M B ARRY WOOD, J R. 1910—1971 A Biographical Memoir by J AMES G. HIRSCH Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1980 NATIONAL ACADEMY OF SCIENCES WASHINGTON D.C. WILLIAM BARRY WOOD, JR. May 4, 1910-March 9, 1971 BY JAMES G. HIRSCH ARRY WOOD was born May 4, 1910 in Milton, Massachu- B setts, of parents from established Boston families. His father was a Harvard graduate and a business man. Little information is available about Barry's early childhood, but it was apparently an enjoyable and uneventful one; he grew up along with a sister and a younger brother in a pleasant subur- ban environment. He was enrolled as a day student in the nearby Milton Academy, where one finds the first records of his exceptional talents as a star performer in several sports, a brilliant student, and a natural leader. Young Wood had no special interest in science or medicine. He took a science course as a part of the standard curriculum his senior year at Milton and somewhat to his surprise won a prize as the best student in the course. This event signaled the start of his interest in a career in science. In view of his family background and his prep school record it was a foregone conclusion that he would attend Harvard, but Barry was only seventeen years old when he graduated from Milton, and his parents decided he might profit from an opportunity to broaden his outlook and ma- ture further before entering college.
    [Show full text]
  • DNA in the Courtroom: the 21St Century Begins
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Massachusetts, School of Law: Scholarship Repository DNA in the Courtroom: The 21st Century Begins JAMES T. GRIFFITH, PH.D., CLS (NCA) * SUSAN L. LECLAIR, PH.D., CLS (NCA) ** In 2004 at the 50th anniversary of the discovery of the structure of DNA, one of the speaKers at a “blacK-tie” gala at the Waldorf Astoria in New YorK City was Marvin Anderson. After having served 15 years of a 210-year sentence for a crime that he did not commit, he became one of only 99 people to have been proven innocent through the use of DNA technology 1. As he walKed off the stage, he embraced Dr. Alec Jeffreys, 2 the man who discovered forensic DNA analysis. 3 * James T. Griffith, Ph.D., CLS (NCA) is the Department Chair of the Department of Medical Laboratory Sciences at the University of Massachusetts Dartmouth. ** Susan L. Leclair, Ph.D., CLS (NCA) is the chancellor professor in the Department of Medical Laboratory Sciences at the University of Massachusetts Dartmouth. 1 Innocence Project, Marvin Anderson, http://www.innocenceproject.org/case/display_profile.php?id=99 (last visited (December 14, 2006). 2 Professor Sir Alec John Jeffreys, FRS, is a British geneticist, who developed techniques for DNA fingerprinting and DNA profiling. DNA fingerprinting uses variations in the genetic code to identify individuals. The technique has been applied in forensics for law enforcement, to resolve paternity and immigration disputes, and can be applied to non- human species, for example in wildlife population genetics studies.
    [Show full text]
  • Streptococci
    STREPTOCOCCI Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Older cultures may lose their Gram-positive character. Most streptococci are facultative anaerobes, and some are obligate (strict) anaerobes. Most require enriched media (blood agar). Streptococci are subdivided into groups by antibodies that recognize surface antigens (Fig. 11). These groups may include one or more species. Serologic grouping is based on antigenic differences in cell wall carbohydrates (groups A to V), in cell wall pili-associated protein, and in the polysaccharide capsule in group B streptococci. Rebecca Lancefield developed the serologic classification scheme in 1933. β-hemolytic strains possess group-specific cell wall antigens, most of which are carbohydrates. These antigens can be detected by immunologic assays and have been useful for the rapid identification of some important streptococcal pathogens. The most important groupable streptococci are A, B and D. Among the groupable streptococci, infectious disease (particularly pharyngitis) is caused by group A. Group A streptococci have a hyaluronic acid capsule. Streptococcus pneumoniae (a major cause of human pneumonia) and Streptococcus mutans and other so-called viridans streptococci (among the causes of dental caries) do not possess group antigen. Streptococcus pneumoniae has a polysaccharide capsule that acts as a virulence factor for the organism; more than 90 different serotypes are known, and these types differ in virulence. Fig. 1 Streptococci - clasiffication. Group A streptococci causes: Strep throat - a sore, red throat, sometimes with white spots on the tonsils Scarlet fever - an illness that follows strep throat. It causes a red rash on the body.
    [Show full text]
  • Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research
    A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Hollingsworth, Joseph Rogers Working Paper Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research WZB Discussion Paper, No. P 02-003 Provided in Cooperation with: WZB Berlin Social Science Center Suggested Citation: Hollingsworth, Joseph Rogers (2002) : Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research, WZB Discussion Paper, No. P 02-003, Wissenschaftszentrum Berlin für Sozialforschung (WZB), Berlin This Version is available at: http://hdl.handle.net/10419/50229 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu P 02 – 003 RESEARCH ORGANIZATIONS AND MAJOR DISCOVERIES IN TWENTIETH-CENTURY SCIENCE: A CASE STUDY OF EXCELLENCE IN BIOMEDICAL RESEARCH J.
    [Show full text]
  • Universidade Do Estado Do Rio De Janeiro Centro Biomédico Faculdade De Ciências Médicas
    i Universidade do Estado do Rio de Janeiro Centro Biomédico Faculdade de Ciências Médicas Guilherme da Silva Lourenço Carvalho Formação de biofilme por espécies de Stretptococcus Rio de Janeiro 2012 ii Guilherme da Silva Lourenço Carvalho Formação de biofilme por espécies de Streptococcus Dissertação apresentada, como requisito parcial para obtenção do título de Mestre, ao Programa de Pós-graduação em Microbiologia, da Universidade do Estado do Rio de Janeiro. Área de concentração: Microbiologia Médica Humana. Orientadora: Profa. Dra. Vânia Lúcia Carreira Merquior Coorientadores: Prof. Dr. Rafael Silva Duarte Profa. Dra. Lúcia Teixeira Martins Rio de Janeiro 2012 iii CATALOGAÇÃO NA FONTE UERJ/REDE SIRIUS/BIBLIOTECA CB-A C331 Carvalho, Guilherme da Silva Lourenço. Formação de biofilme por espécies de Streptococcus. / Guilherme da Silva Lourenço Carvalho. - 2012. 79 f. Orientadora: Vânia Lúcia Carreira Merquior. Coorientadores: Rafael Silva Duarte. Lúcia Teixeira Martins. Dissertação (Mestrado) - Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas. Pós-graduação em Microbiologia. 1. Streptococcus. 2. Biofilmes. 3. Virulência. I. Merquior, Vânia Lúcia Carreira II. Duarte, Rafael Silva III. Martins, Lúcia Teixeira. IV. Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. V. Título. CDU 576.951.214 Bibliotecária: Ana Rachel Fonseca de Oliveira CRB7/6382 Autorizo, apenas para fins acadêmicos e científicos, a reprodução total ou parcial desta dissertação, desde que citada a fonte. ________________________________________ _____________________ Assinatura Data iv Guilherme da Silva Lourenço Carvalho Formação de biofilme porespécies de Streptococcus Dissertação apresentada, como requisito parcial para obtenção do título de Mestre, ao Programa de Pós-graduação em Microbiologia, da Universidade do Estado do Rio de Janeiro.
    [Show full text]
  • Synthetic Biology in Fine Art Practice. Doctoral Thesis, Northumbria University
    Citation: Mackenzie, Louise (2017) Evolution of the Subject – Synthetic Biology in Fine Art Practice. Doctoral thesis, Northumbria University. This version was downloaded from Northumbria Research Link: http://nrl.northumbria.ac.uk/38387/ Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University’s research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html EVOLUTION OF THE SUBJECT SYNTHETIC BIOLOGY IN FINE ART PRACTICE LOUISE MACKENZIE PhD 2017 EVOLUTION OF THE SUBJECT SYNTHETIC BIOLOGY IN FINE ART PRACTICE LOUISE MACKENZIE A thesis submitted in partial fulfilment of the requirements of the University of Northumbria at Newcastle for the degree of Doctor of Philosophy Research undertaKen in the Faculty of Arts, Design & Social Sciences in collaboration with the Institute of Genetic Medicine at Newcastle University December 2017 ABSTRACT AcKnowledging a rise in the use of synthetic biology in art practice, this doctoral project draws from vital materialist discourse on biotechnology and biological materials in the worKs of Donna Haraway, Jane Bennett, Rosi Braidotti and Marietta Radomska to consider the liveliness of molecular biological material through art research and practice.
    [Show full text]
  • Human Genetics 1990–2009
    Portfolio Review Human Genetics 1990–2009 June 2010 Acknowledgements The Wellcome Trust would like to thank the many people who generously gave up their time to participate in this review. The project was led by Liz Allen, Michael Dunn and Claire Vaughan. Key input and support was provided by Dave Carr, Kevin Dolby, Audrey Duncanson, Katherine Littler, Suzi Morris, Annie Sanderson and Jo Scott (landscaping analysis), and Lois Reynolds and Tilli Tansey (Wellcome Trust Expert Group). We also would like to thank David Lynn for his ongoing support to the review. The views expressed in this report are those of the Wellcome Trust project team – drawing on the evidence compiled during the review. We are indebted to the independent Expert Group, who were pivotal in providing the assessments of the Wellcome Trust’s role in supporting human genetics and have informed ‘our’ speculations for the future. Finally, we would like to thank Professor Francis Collins, who provided valuable input to the development of the timelines. The Wellcome Trust is a charity registered in England and Wales, no. 210183. Contents Acknowledgements 2 Overview and key findings 4 Landmarks in human genetics 6 1. Introduction and background 8 2. Human genetics research: the global research landscape 9 2.1 Human genetics publication output: 1989–2008 10 3. Looking back: the Wellcome Trust and human genetics 14 3.1 Building research capacity and infrastructure 14 3.1.1 Wellcome Trust Sanger Institute (WTSI) 15 3.1.2 Wellcome Trust Centre for Human Genetics 15 3.1.3 Collaborations, consortia and partnerships 16 3.1.4 Research resources and data 16 3.2 Advancing knowledge and making discoveries 17 3.3 Advancing knowledge and making discoveries: within the field of human genetics 18 3.4 Advancing knowledge and making discoveries: beyond the field of human genetics – ‘ripple’ effects 19 Case studies 22 4.
    [Show full text]
  • 157Th Meeting of the National Park System Advisory Board November 4-5, 2015
    NORTHEAST REGION Boston National Historical Park 157th Meeting Citizen advisors chartered by Congress to help the National Park Service care for special places saved by the American people so that all may experience our heritage. November 4-5, 2015 • Boston National Historical Park • Boston, Massachusetts Meeting of November 4-5, 2015 FEDERAL REGISTER MEETING NOTICE AGENDA MINUTES Meeting of May 6-7, 2015 REPORT OF THE SCIENCE COMMITTEE NATIONAL PARK SERVICE URBAN AGENDA REPORT ON THE NATIONAL PARK SERVICE COMPREHENSIVE ECONOMIC VALUATION STUDY OVERVIEW OF NATIONAL PARK SERVICE ACTIONS ON ADVISORY BOARD RECOMMENDATIONS • Planning for a Future National Park System • Strengthening NPS Science and Resource Stewardship • Recommending National Natural Landmarks • Recommending National Historic Landmarks • Asian American Pacific Islander, Latino and LGBT Heritage Initiatives • Expanding Collaboration in Education • Encouraging New Philanthropic Partnerships • Developing Leadership and Nurturing Innovation • Supporting the National Park Service Centennial Campaign REPORT OF THE NATIONAL HISTORIC LANDMARKS COMMITTEE PLANNING A BOARD SUMMARY REPORT MEETING SITE—Boston National Historical Park, Commandant’s House, Charlestown Navy Yard, Boston, MA 02139 617-242-5611 LODGING SITE—Hyatt Regency Cambridge, 575 Memorial Drive, Cambridge, MA 62139 617-492-1234 / Fax 617-491-6906 Travel to Boston, Massachusetts, on Tuesday, November 3, 2015 Hotel Check in 4:00 pm Check out 12:00 noon Hotel Restaurant: Zephyr on the Charles / Breakfast 6:30-11:00 am / Lunch 11:00 am - 5:00 pm / Dinner 5-11:00 pm Room Service: Breakfast 6:00 am - 11:00 am / Dinner 5:00 pm - 11:00 pm Wednesday NOVEMBER 4 NOTE—Meeting attire is business. The tour will involve some walking and climbing stairs.
    [Show full text]
  • Biography of Rebecca Craighill Lancefield
    NATIONAL ACADEMY OF SCIENCES R E B ECCA CRAIGHILL L ANCEFIELD 1895—1981 A Biographical Memoir by MACLYN MCCARTY Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1987 NATIONAL ACADEMY OF SCIENCES WASHINGTON D.C. REBECCA CRAIGHILL LANCEFIELD January 5, 1895-March 3, 1981 BY MACLYN McCARTY EBECCA CRAIGHILL LANCEFIELD was born on Janu- R ary 5, 1895, in Fort Wadsworth, New York, where her father, Col. William E. Craighill, was stationed as an officer in the U.S. Army Engineer Corps. As a member of an Army family, she lived in many different communities during her early years. After graduating from Wellesley College, how- ever, and spending one year teaching in a girls school in Ver- mont, she returned to New York City. Except for a year's sojourn at the University of Oregon, she spent the remainder of her life there. Her first move toward a career in science apparently came at Wellesley. Stimulated by her roommate's course in zoology, she dropped her notion of majoring in French and English and concentrated her efforts on biology. By the time she graduated in 1916, she was eager to begin graduate training. But she was forced to compromise: funds were short because of the death of her father, and her mother needed her help in supporting her five sisters. She saved enough from her earnings as a teacher during the following year to enable her to accept a scholarship with graduate tuition at Teachers' Col- lege of Columbia University.
    [Show full text]
  • René Dubos: Wooing the Earth, from Soil Microbes to Human Ecology
    René Dubos: Wooing the Earth, from Soil Microbes to Human Ecology Carol L. Moberg1 The Rockefeller University, New York, New York, United States Figure 1: René Dubos at home on the woodland property he restored after buying an abandoned farm, Garrison, New York. 7 April 1972 Source: Photograph © Lawrence R. Moberg. René Dubos was an ecologist from the beginning. He championed the philosophy that a living organism—whether a microbe, human being, society, or the Earth itself—could be understood only in its relationships with everything else (Moberg, 2005). Each stage in Dubos’s career broadened his exploration of this philosophy 1 Author contact: [email protected] 65 Human Ecology Review, Volume 23, Number 2, 2017 as he evolved during half a century from studies of soil microbes to promoting a “humanistic biology,” in other words, ecology as a humanistic science. Although unknown to Dubos, the term “humanistic science” was not new. In 1922, Ecology, the Ecological Society of America’s (ESA) journal, published an article by Stephen A. Forbes, “The Humanizing of Ecology,” arguing that economic and humanistic values, with applications of botany, bacteriology, zoology, entomology, and physiology, were all “related to the protection and restoration of health and hence to the prolongation of human life.” Of all the biological sciences, Forbes (1922) wrote, ecology is “the humanistic science par excellence” (pp. 90). For Dubos, the philosophical basis of ecology was health. During his final years, he focused on the human condition and how the world that humans inherit, alter, and leave behind would shape their own health.
    [Show full text]