Micro-Heterogeneity of Malaria Transmission in the Peruvian Amazon
Rosas‑Aguirre et al. Malar J (2017) 16:312 DOI 10.1186/s12936-017-1957-y Malaria Journal RESEARCH Open Access Micro‑heterogeneity of malaria transmission in the Peruvian Amazon: a baseline assessment underlying a population‑based cohort study Angel Rosas‑Aguirre1,2, Mitchel Guzman‑Guzman3, Dionicia Gamboa1,3,4, Raul Chuquiyauri1,6, Roberson Ramirez3, Paulo Manrique3, Gabriel Carrasco‑Escobar3,5, Carmen Puemape3, Alejandro Llanos‑Cuentas1,5 and Joseph M. Vinetz1,3,4,6* Abstract Background: Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epide‑ miological survey was conducted in September–October 2012, as a baseline underlying a 3-year population-based longitudinal cohort study. The aim was to characterize malaria transmission patterns in two contrasting ecological rural sites in the Peruvian Amazon, Lupuna (LUP), a riverine environment, and Cahuide (CAH), associated with road- linked deforestation. Methods: After a full population census, 1941 individuals 3 years and older (829 in LUP, 1112 in CAH) were inter‑ viewed, clinically examined and had a blood sample taken for the detection of malaria parasites by microscopy and PCR. Species-specifc parasite prevalence was estimated overall and by site. Multivariate logistic regression models assessed risk factors for parasite infection by PCR, while SaTScan detected spatial clusters of PCR-positive individuals within each site. In addition, data from routine malaria surveillance in the period 2009–2012 were obtained. Results: Parasite prevalence by PCR was higher in CAH than in LUP for Plasmodium vivax (6.2% vs.
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