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Physiological Studies of the Vestibulosympathetic Reflex in Humans
! ! ! Physiological Studies of the Vestibulosympathetic Reflex in Humans Elie Hammam, BMedSci (Hons I) School of Medicine University of Western Sydney Supervisor Prof. Vaughan Macefield Co-Supervisor Prof. Kenny Kwok A thesis submitted to the University of Western Sydney in candidature for the award of Doctor of Philosophy, 2014 ! ! "! ! ! ! STATEMENT OF AUTHENTICATION I, Elie Hammam, declare that this thesis is based entirely on my own independent work, except for sections which were performed in collaboration with colleagues as acknowledged in the study and resulted in the publication of the journal articles shown below. To the best of my knowledge this project does not contain material previously submitted in fulfillment of the guidelines and requirements for the award of Doctor of Philosophy in the School of Medicine, University of Western Sydney, and has not been submitted for qualifications at any other academic institution. Elie Hammam ! ! ! ! #! ! ! ! ACKNOWLEDGEMENTS Undertaking the highest scholarly exercise a University offers has certainly been a long, arduous, but nevertheless a fulfilling journey. Now completed, reflection has allowed me to appreciate that what I have achieved is merely a credit to my efforts. I am deeply indebted to the guidance of my mentors, encouragements from friends and support from family. First and foremost, I wish to acknowledge my stellar supervisor Vaughan Macefield who has never shied from supporting me throughout my candidature. Vaughan, from the very beginning you believed in me and never ceased to impart your knowledge, skills and wisdom. You have ensured all throughout my candidature that I get a holistic development in preparation to a life with academic excellence. -
Potential Mechanisms of Prospective Antimigraine Drugs: a Focus on Vascular (Side) Effects
CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector Pharmacology & Therapeutics 129 (2011) 332–351 Contents lists available at ScienceDirect Pharmacology & Therapeutics journal homepage: www.elsevier.com/locate/pharmthera Associate Editor: John Fozard Potential mechanisms of prospective antimigraine drugs: A focus on vascular (side) effects Kayi Y. Chan a, Steve Vermeersch b, Jan de Hoon b, Carlos M. Villalón c, Antoinette MaassenVanDenBrink a,⁎ a Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands b Center for Clinical Pharmacology, University Hospitals Leuven, Campus Gasthuisberg, (K.U. Leuven), Leuven, Belgium c Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Deleg. Tlalpan, C.P. 14330, México D.F., Mexico article info abstract Available online 2 December 2010 Currently available drugs for the acute treatment of migraine, i.e. ergot alkaloids and triptans, are cranial vasoconstrictors. Although cranial vasoconstriction is likely to mediate—at least a part of—their therapeutic Keywords: effects, this property also causes vascular side-effects. Indeed, the ergot alkaloids and the triptans have been Antimigraine drugs reported to induce myocardial ischemia and stroke, albeit in extremely rare cases, and are contraindicated in Neuropeptides patients with known cardiovascular risk factors. In view of these limitations, novel antimigraine drugs -
Assessment of Traumatic Nerve Injuries
American Association of Neuromuscular & Electrodiagnostic Medicine AANEM ASSESSMENT OF TRAUMATIC NERVE INJURIES Lawrence R. Robinson, MD Jeffrey G. Jarvik, MD, MPH David G. Kline, MD 2005 AANEM COURSE G AANEM 52nd Annual Scientific Meeting Monterey, California Assessment of Traumatic Nerve Injuries Lawrence R. Robinson, MD Jeffrey G. Jarvik, MD, MPH David G. Kline, MD 2005 COURSE G AANEM 52nd Annual Scientific Meeting Monterey, California AANEM Copyright © September 2005 American Association of Neuromuscular & Electrodiagnostic Medicine 421 First Avenue SW, Suite 300 East Rochester, MN 55902 PRINTED BY JOHNSON PRINTING COMPANY, INC. ii Assessment of Traumatic Nerve Injuries Faculty Lawrence R. Robinson, MD David G. Kline, MD Professor Boyd Professor and Head Department of Rehabilitation Medicine Department of Neurosurgery University of Washington Louisiana State University Medical Center Seattle, Washington New Orleans, Louisiana Dr. Robinson attended Baylor College of Medicine and completed his res- Dr. Kline is currently a Boyd Professor and Head of the Department of idency training in rehabilitation medicine at the Rehabilitation Institute of Neurosurgery at Louisiana State University (LSU) Medical Center in New Chicago. He now serves as professor and chair of the Department of Orleans. He earned his medical degree from the University of Rehabilitation Medicine at the University of Washington and is the Pennsylvania, then performed his internship at the University of Michigan. Director of the Harborview Medical Center Electrodiagnostic Laboratory. He performed residencies at the University of Michigan and Walter Reed He is also currently Vice Dean for Clinical Affairs at the University of General Hospital and Institute of Research. Dr. Kline has served on sever- Washington. -
2018 Ibangs Meeting: the 20Th Annual Genes, Brain & Behavior Meeting
5/25/2018 Program for Thursday, May 17th 2018 IBANGS MEETING: THE 20TH ANNUAL GENES, BRAIN & BEHAVIOR MEETING WELCOME PROGRAM INDEXES PROGRAM FOR THURSDAY, MAY 17TH Days: next day all days View: session overview talk overview 08:30-16:00 Session FV: Pre-IBANGS Satellite Meeting, Functional Validation for Neurogenetics Location: Phillips Hall in the Siebens building room 1-11. The Siebens building is located at the Downtown Mayo Clinic Campus (not the Mayo Civic Center). Description:The transformative nature of next generation sequencing has changed how neuroscientists approach genomic sequence variation. Highly multiplexed molecular testing is providing an expanded level of information from which to make informed phenotypic predictions. The importance of this is reflected in the unprecedented expansion of genomic testing to determine the basis of neurologic conditions. Genomic testing results in many instances provide a definitive basis of a neurologic condition. However, in almost a high proportion of cases, the genomic sequencing results are confounded by the ambiguity of variants with uncertain clinical significance. Herein lies the key with which institutions will lead in the area of genomic medicine. There exists a critical need to provide a mechanism by which uncertain findings can be functionally characterized and translated into clinically actionable results. It is within thisr ealm that academic societies such as IBANGS can have a substantial and informative role on the future of clinical research and practice. This symposium will introduce the challenges and opportunities that exist in the field of human clinical neurogenetics and follow this with presentations of active work in the field of functional genetic finding validation for neurogenetics with a look to the future of genomic neurogenetics. -
The Role of Sympathetic Nervous Activity in Chronic Renal Failure
Journal of Clinical and Basic Cardiology An Independent International Scientific Journal Journal of Clinical and Basic Cardiology 2001; 4 (3), 179-182 The Role of Sympathetic Nervous Activity in Chronic Renal Failure Rump LC Homepage: www.kup.at/jcbc Online Data Base Search for Authors and Keywords Indexed in Chemical Abstracts EMBASE/Excerpta Medica Krause & Pachernegg GmbH · VERLAG für MEDIZIN und WIRTSCHAFT · A-3003 Gablitz/Austria FOCUS ON SYMPATHETIC TONE Sympathetic Overactivity in Chronic Renal Failure J Clin Basic Cardiol 2001; 4: 179 The Role of Sympathetic Nervous Activity in Chronic Renal Failure L. C. Rump Cardiovascular morbidity and mortality are extremely high in patients with chronic renal failure. Preventing progression of chronic renal failure and reducing the cardiovascular risk of uraemic patients are major challenges for nephrologists. In the past the renin-angiotensin system has been the main focus of research and therapy efforts. Today we know that sympathetic over- activity plays an important role for progression and prognosis in chronic renal disease. Afferent signals arising from the dam- aged kidneys due to the activation of mechanoreceptors and chemoreceptors lead to efferent sympathetic nervous activation. This results in an enhanced release of the sympathetic neurotransmitters noradrenaline, ATP and NPY at important neuro- effector junctions in heart, kidney and blood vessels. All three sympathetic cotransmitter are able to induce vasoconstriction and to stimulate proliferative processes. Recently it was shown in an animal model of chronic renal failure that inhibition of sympa- thetic nervous activity by moxonidine ameliorates disease progression. This effect was independent from blood pressure reduc- tions and likely due to reduced cotransmitter release. -
TE INI (19 ) United States (12 ) Patent Application Publication ( 10) Pub
US 20200187851A1TE INI (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No .: US 2020/0187851 A1 Offenbacher et al. (43 ) Pub . Date : Jun . 18 , 2020 ( 54 ) PERIODONTAL DISEASE STRATIFICATION (52 ) U.S. CI. AND USES THEREOF CPC A61B 5/4552 (2013.01 ) ; G16H 20/10 ( 71) Applicant: The University of North Carolina at ( 2018.01) ; A61B 5/7275 ( 2013.01) ; A61B Chapel Hill , Chapel Hill , NC (US ) 5/7264 ( 2013.01 ) ( 72 ) Inventors: Steven Offenbacher, Chapel Hill , NC (US ) ; Thiago Morelli , Durham , NC ( 57 ) ABSTRACT (US ) ; Kevin Lee Moss, Graham , NC ( US ) ; James Douglas Beck , Chapel Described herein are methods of classifying periodontal Hill , NC (US ) patients and individual teeth . For example , disclosed is a method of diagnosing periodontal disease and / or risk of ( 21) Appl. No .: 16 /713,874 tooth loss in a subject that involves classifying teeth into one of 7 classes of periodontal disease. The method can include ( 22 ) Filed : Dec. 13 , 2019 the step of performing a dental examination on a patient and Related U.S. Application Data determining a periodontal profile class ( PPC ) . The method can further include the step of determining for each tooth a ( 60 ) Provisional application No.62 / 780,675 , filed on Dec. Tooth Profile Class ( TPC ) . The PPC and TPC can be used 17 , 2018 together to generate a composite risk score for an individual, which is referred to herein as the Index of Periodontal Risk Publication Classification ( IPR ) . In some embodiments , each stage of the disclosed (51 ) Int. Cl. PPC system is characterized by unique single nucleotide A61B 5/00 ( 2006.01 ) polymorphisms (SNPs ) associated with unique pathways , G16H 20/10 ( 2006.01 ) identifying unique druggable targets for each stage . -
View of High Frequency Alternating Currents for Inducing Nerve Block
REDUCTION OF THE ONSET RESPONSE IN HIGH FREQUENCY NERVE BLOCK by DOUGLAS MICHAEL ACKERMANN, JR. Submitted in partial fulfillment of the requirements For the degree of Doctor of Philosophy Dissertation Adviser: Niloy Bhadra, M.D., Ph.D. Department of Biomedical Engineering CASE WESTERN RESERVE UNIVERSITY January, 2010 TITLE PAGE CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the thesis/dissertation of Douglas Michael Ackermann, Jr. candidate for the Ph.D. degree *. (signed) ______________P. Hunter Peckham______________ (chair of the committee) _______________Kevin L. Kilgore_______________ ______________Cameron McIntyre______________ _________________Niloy Bhadra_________________ ___________________Joe Payer___________________ (date) _____November 23, 2009_____ *We also certify that written approval has been obtained for any proprietary material contained therein. COMMITTEE SIGNATURE PAGE DEDICATION I would like to dedicate this dissertation to my wonderful family, friends and colleagues who make life so much fun. TABLE OF CONTENTS TABLE OF CONTENTS ..................................................................................................... i LIST OF TABLES .............................................................................................................. v LIST OF FIGURES ........................................................................................................... vi ACKNOWLEDGEMENTS ............................................................................................ -
An Intra-Neural Microstimulation System for Ultra-High Field Magnetic Resonance Imaging and Magnetoencephalography Paul Glover, Roger H
An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography Paul Glover, Roger H. Watkins, George C. O’neill, Rochelle Ackerley, Rosa Sanchez-Panchuelo, Matthew J. Brookes, Johan Wessberg, Susan T. Francis, Francis Mcglone To cite this version: Paul Glover, Roger H. Watkins, George C. O’neill, Rochelle Ackerley, Rosa Sanchez-Panchuelo, et al.. An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography. Journal of Neuroscience Methods, Elsevier, 2017, 290, pp.69 - 78. 10.1016/j.jneumeth.2017.07.016. hal-01599604 HAL Id: hal-01599604 https://hal.archives-ouvertes.fr/hal-01599604 Submitted on 2 Oct 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Journal of Neuroscience Methods 290 (2017) 69–78 Contents lists available at ScienceDirect Journal of Neuroscience Methods jo urnal homepage: www.elsevier.com/locate/jneumeth Research Paper An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography a,∗ b a b,c Paul M. Glover , Roger H. Watkins , George C. O’Neill , Rochelle Ackerley , a d,e a b Rosa Sanchez-Panchuelo , Francis McGlone , Matthew J. -
Ion Channels
UC Davis UC Davis Previously Published Works Title THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels. Permalink https://escholarship.org/uc/item/1442g5hg Journal British journal of pharmacology, 176 Suppl 1(S1) ISSN 0007-1188 Authors Alexander, Stephen PH Mathie, Alistair Peters, John A et al. Publication Date 2019-12-01 DOI 10.1111/bph.14749 License https://creativecommons.org/licenses/by/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California S.P.H. Alexander et al. The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. British Journal of Pharmacology (2019) 176, S142–S228 THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels Stephen PH Alexander1 , Alistair Mathie2 ,JohnAPeters3 , Emma L Veale2 , Jörg Striessnig4 , Eamonn Kelly5, Jane F Armstrong6 , Elena Faccenda6 ,SimonDHarding6 ,AdamJPawson6 , Joanna L Sharman6 , Christopher Southan6 , Jamie A Davies6 and CGTP Collaborators 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK 2Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK 3Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK 4Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria 5School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK 6Centre for Discovery Brain Science, University of Edinburgh, Edinburgh, EH8 9XD, UK Abstract The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. -
Pdf4 Complex I and the Aryl Palladium Precursor II Underwent Sequential Single Electron Abstraction from Aryl Pd(II) Complex
Design, synthesis, methodology development, and evaluation of PET imaging agents targeting cancer and CNS disorders By Gengyang Yuan B.S. in Chemical Engineering and Technology, Zhejiang University of Technology M.S. in Pharmaceutical Engineering, Zhejiang University A dissertation submitted to The Faculty of the College of Science of Northeastern University in partial fulfillment of the requirements for the degree of Doctor of Philosophy April 21, 2017 Dissertation directed by Michael P. Pollastri Associate Professor and Chair of Chemistry and Chemical Biology Co-directed by Neil Vasdev Adjunct Associate Professor of Chemsitry and Chemical Biology Associate Professor of Radiology, Massachusetts General Hospital and Harvard Medical School Dedication To my parents Zhijun and Yongmian and my wife Ran and daughter Isabella ii Acknowledgements This dissertation would not have been possible without the support, guidance and encouragement of numerous people who have helped me along the way. First and foremost, I would like to thank Northeastern University and the Department of Chemistry and Chemical Biology for supporting me to pursue my doctoral study. I would like to especially thank my current advisor Professor Michael Pollastri for helping me out when I needed it the most. I appreciate you for taking me into your group and giving me full support to finish my thesis projects. I also especially thank my co-advisor Professor Neil Vasdev for taking me into his group at Mass. General Hospital & Harvard Medical School and teaching me the PET radiochemistry and PET imaging. I could not image how I could accomplish this work without your help. I also got a lot of help from Dr. -
WCBR Program3
Welcome to the Thirty-Fifth Annual Winter Conference on Brain Research The Winter Conference on Brain Research (WCBR) was founded in 1968 to promote free exchange of information and ideas within neuroscience. It was the intent of the founders that both formal and informal interactions would occur between clinical and laboratory based neuroscientists. During the past thirty years neuroscience has grown and expanded to include many new fields and methodologies. This diversity is also reflected by WCBR participants and in our program. A primary goal of the WCBR is to enable participants to learn about the current status of areas of neuroscience other than their own. Another objective is to provide a vehicle for scientists with common interests to discuss current issues in an informal setting. On the other hand, WCBR is not designed for presentations limited to communicating the latest data to a small group of specialists; this is best done at national society meetings. The program includes panels (reviews for an audience not neces- sarily familiar with the area presented), workshops (informal discussions of current issues and data), and a number of posters. The annual conference lecture will be presented at the Sunday breakfast on Sunday, January 27. Our guest speaker will be Dr. Donald Kennedy, Editor-in-Chief of Science. On Tuesday, January 29, a town meeting will be held for the Aspen/Snowmass commu- nity at which Dr. George Ricaurte, and WCBR participants will discuss drug addiction and toxicity of addictive drugs. Also, participants in the WCBR Outreach Program will present sessions at local schools throughout the week to pique students’ interest in science. -
Neural Control of the Cardiovascular System in Space 177 Figure 3
Experiment Team Neural Control of the Principal Investigator: C. Gunnar Blomqvist’ Cardiovascular System Co-Investigators: Benjamin D. Levinel James A. Pawelczyk2 in Space Lynda D. Lane3 Cole A. Gillerl E Andrew Gaffney3 Authors Benjamin D. Levine, James A. Pawelczyk, ‘University of Texas Southwestern Medical Center, Julie H. Zuckerman, Rong Zhang, Qi Fu, Dallas, USA Kenichi Iwasaki, Chet Ray, C. Gunnar Blomqvist *The Pennsylvania State University, University Park, USA Vanderbilt University, Nashville, USA ABSTRACT During the acute transition from lying supine to standing upright, a large volume of blood suddenly moves from the chest into the legs. To prevent fainting, the blood pressure control system senses this change immediately, and rapidly adjusts flow (by increasing heart rate) and resistance to flow (by constricting the blood vessels) to restore blood pressure and maintain brain blood flow. If this system is inadequate, the brain has a “backup plan.” Blood vessels in the brain can adjust their diameter to keep blood flow constant. If blood pressure drops, the brain blood vessels dilate; if blood pressure increases, the brain blood vessels constrict. This process, which is called “autoreg- ulation,” allows the brain to maintain a steady stream of oxygen, even when blood pressure changes. We examined what changes in the blood pressure control system or cerebral autoregulation contribute to the blood pressure con- trol problems seen after spaceflight. We asked: (1) does the adaptation to spaceflight cause an adaptation in the blood pressure control system that impairs the ability of the system to constrict blood vessels on return to Earth?; (2)if such a defect exists, could we pinpoint the neural pathways involved?; and (3) does cerebral autoregulation become abnormal during spaceflight, impairing the body’s ability to maintain constant brain blood flow when standing upright on Earth? We stressed the blood pressure control system using lower body negative pressure, upright tilt, handgrip exercise, and cold stimulation of the hand.