2020 Aetna Pharmacy Drug Guide Aetna Standard Plan

Total Page:16

File Type:pdf, Size:1020Kb

2020 Aetna Pharmacy Drug Guide Aetna Standard Plan Plan for your best health 2020 Aetna Pharmacy Drug Guide Aetna Standard Plan 05.02.472.1 (01/01) aetna.com Aetna is the brand name used for products and services provided by one or more of the Aetna group of subsidiary companies, including Aetna Life Insurance Company and its affiliates (Aetna). Aetna Pharmacy Management refers to an internal business unit of Aetna Health Management, LLC. Aetna Pharmacy Management administers, but does not offer, insure or otherwise underwrite the prescription drug benefits portion of your health plan and has no financial responsibility therefor. 2020 Pharmacy Drug Guide - Aetna Standard Plan Table of Contents INFORMATIONAL SECTION..................................................................................................................8 *5-HT4 RECEPTOR AGONISTS*** - DRUGS FOR THE STOMACH.................................................. 8 *ADENOSINE RECEPTOR ANTAGONIST*** - DRUGS FOR THE NERVOUS SYSTEM............... 8 *ADHD/ANTI-NARCOLEPSY/ANTI-OBESITY/ANOREXIANTS* - DRUGS FOR THE NERVOUS SYSTEM...................................................................................................................................8 *AGENTS FOR NARCOTIC WITHDRAWAL*** - DRUGS FOR ADDICTION.................................9 *AGENTS FOR OPIOID WITHDRAWAL*** - DRUGS FOR ADDICTION......................................10 *ALTERNATIVE MEDICINES* - VITAMINS AND MINERALS....................................................... 10 *AMEBICIDES* - DRUGS FOR INFECTIONS.....................................................................................10 *AMINOGLYCOSIDES* - DRUGS FOR INFECTIONS.......................................................................10 *AMINOMETHYLCYCLINES*** - DRUGS FOR INFECTIONS....................................................... 10 *ANALGESICS - ANTI-INFLAMMATORY* - DRUGS FOR PAIN AND FEVER............................10 *ANALGESICS - NONNARCOTIC* - DRUGS FOR PAIN AND FEVER.......................................... 14 *ANALGESICS - OPIOID* - DRUGS FOR PAIN AND FEVER.......................................................... 16 *ANDROGENS-ANABOLIC* - HORMONES........................................................................................20 *ANORECTAL AGENTS* - RECTAL PREPARATIONS..................................................................... 21 *ANTACIDS* - DRUGS FOR THE STOMACH.....................................................................................21 *ANTHELMINTICS* - DRUGS FOR INFECTIONS............................................................................ 21 *ANTIANGINAL AGENTS* - DRUGS FOR THE HEART................................................................. 22 *ANTIANXIETY AGENTS* - DRUGS FOR THE NERVOUS SYSTEM.............................................22 *ANTIARRHYTHMICS* - DRUGS FOR THE HEART....................................................................... 23 *ANTIASTHMATIC AND BRONCHODILATOR AGENTS* - DRUGS FOR THE LUNGS............ 23 *ANTICOAGULANTS - MISC.*** - DRUGS FOR THE BLOOD........................................................ 26 *ANTICOAGULANTS* - DRUGS FOR THE BLOOD..........................................................................26 *ANTICONVULSANTS* - DRUGS FOR THE NERVOUS SYSTEM.................................................. 27 *ANTIDEMENTIA AGENT COMBINATIONS*** - DRUGS FOR THE NERVOUS SYSTEM........29 *ANTIDEPRESSANTS* - DRUGS FOR THE NERVOUS SYSTEM....................................................29 *ANTIDIABETICS* - HORMONES........................................................................................................31 *ANTIDIARRHEAL/PROBIOTIC AGENTS* - DRUGS FOR THE STOMACH................................ 35 *ANTIDIARRHEALS* - DRUGS FOR THE STOMACH..................................................................... 35 *ANTIDOTES AND SPECIFIC ANTAGONISTS* - DRUGS FOR OVERDOSE OR POISONING...35 *ANTIDOTES* - DRUGS FOR OVERDOSE OR POISONING............................................................ 35 *ANTIEMETICS* - DRUGS FOR THE STOMACH..............................................................................36 *ANTIFUNGALS* - DRUGS FOR INFECTIONS.................................................................................37 *ANTIHEMOPHILIC PRODUCTS - MONOCLONAL ANTIBODIES*** - DRUGS FOR THE BLOOD...................................................................................................................................................... 37 *ANTIHISTAMINES* - DRUGS FOR THE LUNGS.............................................................................37 *ANTIHYPERLIPIDEMICS MISC. COMBINATIONS*** - DRUGS FOR THE HEART..................38 *ANTIHYPERLIPIDEMICS* - DRUGS FOR THE HEART.................................................................38 *ANTIHYPERTENSIVES* - DRUGS FOR THE HEART..................................................................... 40 *ANTI-INFECTIVE AGENTS - MISC.* - DRUGS FOR INFECTIONS...............................................42 *ANTIMALARIALS* - DRUGS FOR INFECTIONS............................................................................ 43 *ANTIMYASTHENIC AGENTS* - DRUGS FOR NERVES AND MUSCLES....................................43 *ANTIMYASTHENIC/CHOLINERGIC AGENTS* - DRUGS FOR NERVES AND MUSCLES.......43 *ANTIMYCOBACTERIAL AGENTS* - DRUGS FOR INFECTIONS................................................ 43 *ANTINEOPLASTIC - FGFR KINASE INHIBITORS*** - DRUGS FOR CANCER......................... 44 TOC-3 *ANTINEOPLASTIC - TROPOMYOSIN RECEPTOR KINASE INHIBITORS*** - DRUGS FOR CANCER....................................................................................................................................................44 *ANTINEOPLASTIC - XPO1 INHIBITORS*** - DRUGS FOR CANCER.......................................... 44 *ANTINEOPLASTIC OR PREMALIGNANT LESION AGENT - COMB*** - DRUGS FOR CANCER....................................................................................................................................................44 *ANTINEOPLASTICS AND ADJUNCTIVE THERAPIES* - DRUGS FOR CANCER......................44 *ANTI-OBESITY AGENT COMBINATIONS** - DRUGS FOR EATING DISORDERS...................49 *ANTIPARKINSON AGENTS* - DRUGS FOR THE NERVOUS SYSTEM....................................... 49 *ANTIPSORIATIC COMBINATIONS*** - DRUGS FOR THE SKIN................................................. 50 *ANTIPSYCHOTICS/ANTIMANIC AGENTS* - DRUGS FOR THE NERVOUS SYSTEM..............50 *ANTIRETROVIRALS ADJUVANTS*** - DRUGS THAT ALTER METABOLISM.........................52 *ANTISENSE OLIGONUCLEOTIDE (ASO) INHIBITOR AGENTS*** - HORMONES....................52 *ANTISEPTICS & DISINFECTANTS* - ANTISEPTICS AND DISINFECTANTS.............................52 *ANTIVIRALS* - DRUGS FOR INFECTIONS..................................................................................... 52 *ANTI-VON WILLEBRAND FACTOR AGENTS*** - DRUGS FOR THE BLOOD.......................... 55 *ASSORTED CLASSES* - VITAMINS AND MINERALS.................................................................... 55 *ATOPIC DERMATITIS - MONOCLONAL ANTIBODIES*** - DRUGS FOR THE LUNGS.......... 56 *BACTERIAL MONOCLONAL ANTIBODIES*** - BIOLOGICAL AGENTS................................... 56 *B-COMPLEX W/ E & FOLIC ACID*** - DRUGS FOR NUTRITION................................................57 *BETA BLOCKER & ANGIOTENSIN II RECEPTOR ANTAGONIST COMB*** - DRUGS FOR THE HEART............................................................................................................................................. 57 *BETA BLOCKERS* - DRUGS FOR THE HEART...............................................................................57 *BIGUANIDE-DIABETIC SUPPLIES COMBINATIONS*** - HORMONES......................................58 *BILE ACID SYNTHESIS DISORDER AGENTS*** - DRUGS FOR THE STOMACH.....................58 *BIOLOGICALS MISC* - BIOLOGICAL AGENTS...............................................................................58 *CALCITONIN GENE-RELATED PEPTIDE (CGRP) RECEPTOR ANTAG*** - DRUGS FOR THE NERVOUS SYSTEM........................................................................................................................58 *CALCIUM CHANNEL BLOCKERS* - DRUGS FOR THE HEART..................................................58 *CARDIOTONICS* - DRUGS FOR THE HEART.................................................................................59 *CARDIOVASCULAR AGENTS - MISC.* - DRUGS FOR THE HEART........................................... 60 *CEPHALOSPORINS* - DRUGS FOR INFECTIONS.......................................................................... 61 *CHEMICALS*......................................................................................................................................... 61 *CIC AGENTS - GUANYLATE CYCLASE-C (GC-C) AGONISTS*** - DRUGS FOR THE STOMACH................................................................................................................................................ 62 *CONTRACEPTIVES* - DRUGS FOR WOMEN...................................................................................62 *CORTICOSTEROIDS* - HORMONES..................................................................................................68 *COUGH/COLD/ALLERGY* - DRUGS FOR THE LUNGS................................................................ 70 *CYCLIN-DEPENDENT KINASES (CDK) INHIBITORS*** - DRUGS FOR CANCER...................71 *CYSTIC FIBROSIS AGENT - COMBINATIONS*** - DRUGS FOR THE LUNGS.......................... 71 *DERMATOLOGICALS*
Recommended publications
  • Incremental Costs of Introducing Jet Injection Technology for Delivery of Routine Childhood Vaccinations: Comparative Analysis from Brazil, India, and South Africa
    Vaccine 29 (2011) 969–975 Contents lists available at ScienceDirect Vaccine journal homepage: www.elsevier.com/locate/vaccine Incremental costs of introducing jet injection technology for delivery of routine childhood vaccinations: Comparative analysis from Brazil, India, and South Africa Ulla K. Griffiths a,∗, Andreia C. Santos a, Neeti Nundy b, Erica Jacoby b, Dipika Matthias b a London School of Hygiene and Tropical Medicine, Tavistock Place, London WC1H 9SH, UK b PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA article info abstract Article history: Background: Disposable-syringe jet injectors (DSJIs) have the potential to deliver vaccines safely and Received 14 May 2010 affordably to millions of children around the world. We estimated the incremental costs of transitioning Received in revised form 9 November 2010 from needles and syringes to delivering childhood vaccines with DSJIs in Brazil, India, and South Africa. Accepted 15 November 2010 Methods: Two scenarios were assessed: (1) DSJI delivery of all vaccines at current dose and depth; (2) a Available online 27 November 2010 change to intradermal (ID) delivery with DSJIs for hepatitis B and yellow fever vaccines, while the other vaccines are delivered by DSJIs at current dose and depth. The main advantage of ID delivery is that only Keywords: a small fraction of the standard dose may be needed to obtain an immune response similar to that of Vaccine Jet injector subcutaneous or intramuscular injection. Cost categories included were vaccines, injection equipment, Costs waste management, and vaccine transport. Some delivery cost items, such as training and personnel Brazil were excluded as were treatment cost savings caused by a reduction in diseases transmitted due to India unsafe injections.
    [Show full text]
  • Wachter-Et-Al-LSM-32(2003)101-110.Pdf
    Lasers in Surgery and Medicine 32:101–110 (2003) Topical Rose Bengal: Pre-Clinical Evaluation of Pharmacokinetics and Safety 1 1 1 1 2 Eric Wachter, PhD, * Craig Dees, PhD, Jay Harkins, Timothy Scott, PhD, Mark Petersen, DVM, 3 4 Rusty E. Rush, MS, and Amy Cada, PhD 1Provectus Pharmaceuticals, Inc., Knoxville, Tennessee 37931 2College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37916 3Springborn Laboratories, Inc., Spencerville, Ohio 45887 4Therimmune Research Corporation, Gaithersburg, Maryland 20879 Background and Objectives: Rose bengal (RB) is a should have minimal potential for side effects, such as potent photosensitizer that has largely been overlooked as a prolonged photosensitivity. potential photodynamic therapy (PDT) agent. In this study, Since RB readily photobleaches [29], its photodynamic the feasibility of topical delivery of RB to the epidermis has effects may be self-limiting. This is particularly relevant for been evaluated. treatment of many dermatologic conditions, such as psoria- Study Design/Materials and Methods: Topical formu- sis and actinic keratosis, since precise light dosimetry is lations of RB were assessed on murine and rabbit skin for impractical over the large surface areas typically involved pharmacokinetic properties, cutaneous toxicity, and photo- in these diseases: a PDT regimen that exhibits self-limiting sensitization. effects would avoid the need for complex light dosimetry. Results: Hydrophilic formulations (1% RB) exhibited The combination of photodynamic potential, substantial
    [Show full text]
  • (12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak Et Al
    US008343962B2 (12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak et al. (45) Date of Patent: *Jan. 1, 2013 (54) TOPICAL FORMULATION (58) Field of Classi?cation Search ............. .. 514/226.5, 514/334, 420, 557, 567 (75) Inventors: Edward T. Kisak, San Diego, CA (US); See application ?le fOr Complete Search history. John M. NeWsam, La Jolla, CA (US); _ Dominic King-Smith, San Diego, CA (56) References C‘ted (US); Pankaj Karande, Troy, NY (US); Samir Mitragotri, Goleta, CA (US) US' PATENT DOCUMENTS 5,602,183 A 2/1997 Martin et al. (73) Assignee: NuvoResearchOntano (CA) Inc., Mississagua, 6,328,979 2B1 12/2001 Yamashita et a1. 7,001,592 B1 2/2006 Traynor et a1. ( * ) Notice: Subject to any disclaimer, the term of this 7,795,309 B2 9/2010 Kisak eta1~ patent is extended or adjusted under 35 2002/0064524 A1 5/2002 Cevc U.S.C. 154(b) by 212 days. FOREIGN PATENT DOCUMENTS This patent is subject to a terminal dis- W0 WO 2005/009510 2/2005 claimer- OTHER PUBLICATIONS (21) APPI' NO‘, 12/848,792 International Search Report issued on Aug. 8, 2008 in application No. PCT/lB2007/0l983 (corresponding to US 7,795,309). _ Notice ofAlloWance issued on Apr. 29, 2010 by the Examiner in US. (22) Med Aug- 2’ 2010 Appl. No. 12/281,561 (US 7,795,309). _ _ _ Of?ce Action issued on Dec. 30, 2009 by the Examiner in US. Appl. (65) Prior Publication Data No, 12/281,561 (Us 7,795,309), Us 2011/0028460 A1 Feb‘ 3’ 2011 Primary Examiner * Raymond Henley, 111 Related U 5 Application Data (74) Attorney, Agent, or Firm * Foley & Lardner LLP (63) Continuation-in-part of application No.
    [Show full text]
  • Ophthalmic Herpes Zoster
    OPHTHALMIC HERPES ZOSTER RONALD J. MARSH and MATTHEW COOPER London SUMMARY Fig. 1 shows the age and sex distribution, which is A current review of ophthalmic zoster is presented biased in favour of females and compares with 50.7% including its virology, immunology, epidemiology and males, 49.3% females in another series.5 The 1981 census pathogenesis. We give our findings in 1356 patients for Greater London recorded 48% males and 52% referred to the Zoster Clinic at Moorfields Ey e Hospital, females. London. The treatment of the disease and its ocular com­ ONSET plications is discussed. There is a prodromal influenza-like illness of varying Ophthalmic herpes zoster is a disease varying in severity duration, with headache, pyrexia, malaise, depression, and from devastating, threatening life and sight, to so mild that sometimes neck stiffness, which may last up to a week it may pass unnoticed. The ophthalmic division of the fifth before the rash appears. This is shortly followed by local­ cranial nerve is affected in 7-17.5% of herpes zoster ised pain over the distribution of the ophthalmic nerve, patients. 1-5 Ocular involvement complicates approxi­ lymph node swelling in the corresponding drainage areas mately 50% of these cases and very rarely cases of maxil­ and, occasionally, a red eye. The localised pain is well lary herpes zoster,l affecting many of the tissues of the known to precede the rash by several days in some cases. globe and orbit by highly varied types of lesions. This probably represents the replication and migration We felt it would be helpful to report our experience with phase of the disease and is possibly accompanied by a lim­ the disease because the large number of cases we have ited viraemia.
    [Show full text]
  • 3-Local-Anesthetics.Pdf
    Overview • Local anesthetics produce a transient and reversible loss of sensation (analgesia) in a circumscribed region of the body without loss of consciousness. • Normally, the process is completely reversible. • Local anesthetics are generally classified as either esters or amides and are usually linked to: – a lipophilic aromatic group – to a hydrophilic, ionizable tertiary (sometimes secondary) amine. • Most are weak bases with pKa ( 8 – 9), and at physiologic pH they are primarily in the charged, cationic form. • The potency of local anesthetics is positively correlated with their lipid solubility, which may vary 16-fold, and negatively correlated with their molecular size. • These anesthetics are selected for use on the basis of: 1. the duration of drug action • Short: 20 min • Intermediate: 1—1.5 hrs • Long: 2—4 hrs 2. effectiveness at the administration site 3. potential for toxicity Mechanism of action Local anesthetics act by blocking sodium channels and the conduction of action potentials along sensory nerves. • Blockade is voltage dependent and time dependent. a. At rest, the voltage-dependent sodium (Na+) channels of sensory nerves are in the resting (closed) state. • Following the action potential the Na+ channel becomes active (open) and then converts to an inactive (closed) state that is insensitive to depolarization. • Following repolarization of the plasma membrane there is a slow reversion of channels from the inactive to the resting state, which can again be activated by depolarization. • During excitation the cationic charged form of local anesthetics interacts preferentially with the inactivated state of the Na+ channels on the inner aspect of the sodium channel to block sodium current and increase the threshold for excitation.
    [Show full text]
  • Study Protocol and Statistical Analysis Plan
    Confidential Clinical study protocol number: J1228 Page 1 Version Date: May 7, 2018 IRB study Number: NA_00067315 A Trial of maintenance Rituximab with mTor inhibition after High-dose Consolidative Therapy in CD20+, B-cell Lymphomas, Gray Zone Lymphoma, and Hodgkin’s Lymphoma Principal Investigator: Douglas E. Gladstone, MD The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 1650 Orleans Street, CRBI-287 Baltimore, MD 21287 Phone: 410-955-8781 Fax: 410-614-1005 Email: [email protected] IRB Protocol Number: NA_00067315 Study Number: J1228 IND Number: EXEMPT Novartis Protocol Number: CRAD001NUS157T Version: May 7, 2018 Co-Investigators: Jonathan Powell 1650 Orleans Street, CRBI-443 Phone: 410-502-7887 Fax: 443-287-4653 Email: [email protected] Richard Jones 1650 Orleans Street, CRBI-244 Phone: 410-955-2006 Fax: 410-614-7279 Email: [email protected] Confidential Clinical study protocol number: J1228 Page 2 Version Date: May 7, 2018 IRB study Number: NA_00067315 Satish Shanbhag Johns Hopkins Bayview Medical Center 301 Building, Suite 4500 4940 Eastern Ave Phone: 410-550-4061 Fax: 410-550-5445 Email: [email protected] Statisticians: Gary Rosner Phone: 410-955-4884 Email: [email protected] Marianna Zahurak Phone: 410-955-4219 Email: [email protected] Confidential Clinical study protocol number: J1228 Page 3 Version Date: May 7, 2018 IRB study Number: NA_00067315 Table of contents Table of contents ......................................................................................................................... 3 List of abbreviations
    [Show full text]
  • Daidzein and Genistein Content of Cereals
    European Journal of Clinical Nutrition (2002) 56, 961–966 ß 2002 Nature Publishing Group All rights reserved 0954–3007/02 $25.00 www.nature.com/ejcn ORIGINAL COMMUNICATION Daidzein and genistein content of cereals J Liggins1, A Mulligan1,2, S Runswick1 and SA Bingham1,2* 1Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge, UK; and 2European Prospective Investigation of Cancer, University of Cambridge, Cambridge, UK Objective: To analyse 75 cereals and three soy flours commonly eaten in Europe for the phytoestrogens daidzein and genistein. Design: The phytoestrogens daidzein and genistein were extracted from dried foods, and the two isoflavones quantified after hydrolytic removal of any conjugated carbohydrate. Completeness of extraction and any procedural losses of the isoflavones 0 0 were accounted for using synthetic daidzin (7-O-glucosyl-4 -hydroxyisoflavone) and genistin (7-O-glucosyl-4 5-dihydroxyiso- flavone) as internal standards. Setting: Foods from the Cambridge UK area were purchased, prepared for eating, which included cooking if necessary, and freeze dried. Three stock soy flours were also analysed. Results: Eighteen of the foods assayed contained trace or no detectable daidzein or genistein. The soy flours were rich sources, containing 1639 – 2117 mg=kg. The concentration of the two isoflavones in the remaining foods ranged from 33 to 11 873 mg=kg. Conclusion: These analyses will supply useful information to investigators determining the intake of phytoestrogens in cereal products in order to relate intakes to potential biological activities. Sponsorship: This work was supported by the United Kingdom Medical Research Council, Ministry of Agriculture Fisheries and Food (contract FS2034) and the United States of America Army (contract DAMD 17-97-1-7028).
    [Show full text]
  • Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
    Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate.
    [Show full text]
  • For Nexplanon® Insertion and Removal G
    Wilson et al. Contraception and Reproductive Medicine (2020) 5:1 Contraception and https://doi.org/10.1186/s40834-020-00104-x Reproductive Medicine RESEARCH Open Access Comparison of traditional anesthesia method and jet injector anesthesia method (MadaJet XL®) for Nexplanon® insertion and removal G. Anthony Wilson* , Julie W. Jeter, William S. Dabbs, Amy Barger Stevens, Robert E. Heidel and Shaunta’ M. Chamberlin Abstract Background: This study compared a needle-free anesthesia method with traditional local anesthesia for insertion and removal of Nexplanon® long-acting removable contraceptive device. In our clinic, patients often avoid this highly effective form of contraception due to fear of needles. We sought to determine if patients perceived a difference in pain with the injection, anxiety level or pain with the procedure when local anesthesia was given with a needle v/s a needle-free jet injector device. Methods: Patients were randomly assigned to one of two groups: jet injector or needle lidocaine delivery. Outcomes were ease of use, patient anxiety level, painfulness, and efficacy of anesthesia method. Results: Patient pain perception with administration of jet injector lidocaine was statistically lower than traditional needle with no difference in anxiety or ease of use, or efficacy of the anesthesia. Conclusion: The jet injector device is a reasonable alternative to needle injection delivery of anesthesia prior to insertion/removal of Nexplanon® device. Further studies may determine whether this needle-free alternative for administration of local anesthetic would result in more women choosing Nexplanon® as a contraceptive method. Keywords: Local anesthetic, Nexplanon®, Patient anxiety Background injection of lidocaine differed between the methods of As with many procedures [1, 2], patients often cite a fear delivery, and whether the presence or absence of needles of needles as a major reason to decline Nexplanon® in the anesthesia method affected patient anxiety level.
    [Show full text]
  • WO 2016/133483 Al 25 August 2016 (25.08.2016) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization I International Bureau (10) International Publication Number (43) International Publication Date WO 2016/133483 Al 25 August 2016 (25.08.2016) P O P C T (51) International Patent Classification: SHENIA, Iaroslav Viktorovych [UA/UA]; Feodosiyskyy A61L 15/44 (2006.01) A61L 26/00 (2006.01) lane, 14-a, kv. 65, Kyiv, 03028 (UA). A61L 15/54 (2006.01) (74) Agent: BRAGARNYK, Oleksandr Mykolayovych; str. (21) International Application Number: Lomonosova, 60/5-43, Kyiv, 03189 (UA). PCT/UA20 16/0000 19 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 15 February 2016 (15.02.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (30) Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, a 2015 01285 16 February 2015 (16.02.2015) UA PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, u 2015 01288 16 February 2015 (16.02.2015) UA SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (72) Inventors; and TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
    [Show full text]
  • Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management
    Pharmacology & Pharmacy, 2012, 3, 291-294 291 http://dx.doi.org/10.4236/pp.2012.33038 Published Online July 2012 (http://www.SciRP.org/journal/pp) Prolonged Release of the Local Anesthetic Butamben for Potential Use in Pain Management Ashish Rastogi1,2, Salomon Stavchansky2, Phillip D. Bowman1* 1US Army Institute of Surgical Research, Fort Sam Houston, USA; 2Division of Pharmaceutics, College of Pharmacy, The Univer- sity of Texas at Austin, Austin, USA. Email: [email protected], *[email protected] Received March 20th, 2012; revised April 29th, 2012; accepted May 11th, 2012 ABSTRACT Continuous delivery of local anesthetics might be useful for management of localized and chronic pain. Controlled re- lease injectable anesthetics have been developed but they can deliver the drug for only few days and the release is not zero-order. A drug delivery system (DDS) consisting of a perforated reservoir for drug containment and release and its potential for management of chronic pain is described. Proof of principle is detailed for long-term zero order delivery of butamben. In this study, the DDS was a polyimide tube with a 0.20 mm hole and butamben release was evaluated in vitro. It is envisioned that the DDS could be implanted in proximity to a nerve, enervating the pain source, for long-term control of chronic pain. Keywords: Controlled Release; Prolonged Drug Delivery; Pain Management; Butamben 1. Introduction operated, and not suitable for everyone [9]. Persistent cerebrospinal fluid leak during its insertion is also a Long-term drug therapy for pain management is chal- known complication [10].
    [Show full text]
  • 15-CETY-040, Cetecaine Gel Sell Sheet FA No Crops
    Cetacaine® TOPICAL ANESTHETIC GEL (Benzocaine 14.0%, Butamben 2.0%, Tetracaine Hydrochloride 2.0%) Proven more effective than benzocaine alone1 Cetacaine® Topical Anesthetic Gel is a fast-acting, long-lasting prescription topical anesthetic. Applied directly to the mucous membrane, Cetacaine is primarily used to control pain and ease discomfort at the application site. The protective pump-top jar controls the amount of Cetacaine dispensed while keeping the remaining contents safe from cross contamination. The outside lid helps to keep the pump surface clean and intact. Please see the Brief Summary of the Prescribing Information on the reverse side. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Cetacaine Gel is indicated for anesthesia of all Description Size Item No. accessible mucous membrane except the eyes. Cetacaine Topical Anesthetic Gel 32 g 0217 Cetacaine is not for injection. Features & Benefits • Onset of action: Approximately 30 seconds* • Applies evenly and consistently, tissue need not be dried • Duration of action: 30-60 minutes* • Reacts with body temperature to melt and absorb quickly into tissue • Controls pain and eases discomfort at the application site • Made in USA • Pleasant strawberry flavor • Study shows Cetacaine’s triple formula is more effective than • Lubricating qualities Benzocaine alone Important Safety Information • On rare occasions, methemoglobinemia has been reported in • The most common adverse reaction caused by local anesthetics is connection with the use of benzocaine-containing products. contact dermatitis characterized by erythema and pruritus that If a patient becomes cyanotic, treat appropriately to counteract may progress to vesiculation and oozing.
    [Show full text]