PF 44(1) Table of Contents Publish Date: November 1, 2017
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Wachter-Et-Al-LSM-32(2003)101-110.Pdf
Lasers in Surgery and Medicine 32:101–110 (2003) Topical Rose Bengal: Pre-Clinical Evaluation of Pharmacokinetics and Safety 1 1 1 1 2 Eric Wachter, PhD, * Craig Dees, PhD, Jay Harkins, Timothy Scott, PhD, Mark Petersen, DVM, 3 4 Rusty E. Rush, MS, and Amy Cada, PhD 1Provectus Pharmaceuticals, Inc., Knoxville, Tennessee 37931 2College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37916 3Springborn Laboratories, Inc., Spencerville, Ohio 45887 4Therimmune Research Corporation, Gaithersburg, Maryland 20879 Background and Objectives: Rose bengal (RB) is a should have minimal potential for side effects, such as potent photosensitizer that has largely been overlooked as a prolonged photosensitivity. potential photodynamic therapy (PDT) agent. In this study, Since RB readily photobleaches [29], its photodynamic the feasibility of topical delivery of RB to the epidermis has effects may be self-limiting. This is particularly relevant for been evaluated. treatment of many dermatologic conditions, such as psoria- Study Design/Materials and Methods: Topical formu- sis and actinic keratosis, since precise light dosimetry is lations of RB were assessed on murine and rabbit skin for impractical over the large surface areas typically involved pharmacokinetic properties, cutaneous toxicity, and photo- in these diseases: a PDT regimen that exhibits self-limiting sensitization. effects would avoid the need for complex light dosimetry. Results: Hydrophilic formulations (1% RB) exhibited The combination of photodynamic potential, substantial -
(12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak Et Al
US008343962B2 (12) United States Patent (10) Patent N0.: US 8,343,962 B2 Kisak et al. (45) Date of Patent: *Jan. 1, 2013 (54) TOPICAL FORMULATION (58) Field of Classi?cation Search ............. .. 514/226.5, 514/334, 420, 557, 567 (75) Inventors: Edward T. Kisak, San Diego, CA (US); See application ?le fOr Complete Search history. John M. NeWsam, La Jolla, CA (US); _ Dominic King-Smith, San Diego, CA (56) References C‘ted (US); Pankaj Karande, Troy, NY (US); Samir Mitragotri, Goleta, CA (US) US' PATENT DOCUMENTS 5,602,183 A 2/1997 Martin et al. (73) Assignee: NuvoResearchOntano (CA) Inc., Mississagua, 6,328,979 2B1 12/2001 Yamashita et a1. 7,001,592 B1 2/2006 Traynor et a1. ( * ) Notice: Subject to any disclaimer, the term of this 7,795,309 B2 9/2010 Kisak eta1~ patent is extended or adjusted under 35 2002/0064524 A1 5/2002 Cevc U.S.C. 154(b) by 212 days. FOREIGN PATENT DOCUMENTS This patent is subject to a terminal dis- W0 WO 2005/009510 2/2005 claimer- OTHER PUBLICATIONS (21) APPI' NO‘, 12/848,792 International Search Report issued on Aug. 8, 2008 in application No. PCT/lB2007/0l983 (corresponding to US 7,795,309). _ Notice ofAlloWance issued on Apr. 29, 2010 by the Examiner in US. (22) Med Aug- 2’ 2010 Appl. No. 12/281,561 (US 7,795,309). _ _ _ Of?ce Action issued on Dec. 30, 2009 by the Examiner in US. Appl. (65) Prior Publication Data No, 12/281,561 (Us 7,795,309), Us 2011/0028460 A1 Feb‘ 3’ 2011 Primary Examiner * Raymond Henley, 111 Related U 5 Application Data (74) Attorney, Agent, or Firm * Foley & Lardner LLP (63) Continuation-in-part of application No. -
Ophthalmic Herpes Zoster
OPHTHALMIC HERPES ZOSTER RONALD J. MARSH and MATTHEW COOPER London SUMMARY Fig. 1 shows the age and sex distribution, which is A current review of ophthalmic zoster is presented biased in favour of females and compares with 50.7% including its virology, immunology, epidemiology and males, 49.3% females in another series.5 The 1981 census pathogenesis. We give our findings in 1356 patients for Greater London recorded 48% males and 52% referred to the Zoster Clinic at Moorfields Ey e Hospital, females. London. The treatment of the disease and its ocular com ONSET plications is discussed. There is a prodromal influenza-like illness of varying Ophthalmic herpes zoster is a disease varying in severity duration, with headache, pyrexia, malaise, depression, and from devastating, threatening life and sight, to so mild that sometimes neck stiffness, which may last up to a week it may pass unnoticed. The ophthalmic division of the fifth before the rash appears. This is shortly followed by local cranial nerve is affected in 7-17.5% of herpes zoster ised pain over the distribution of the ophthalmic nerve, patients. 1-5 Ocular involvement complicates approxi lymph node swelling in the corresponding drainage areas mately 50% of these cases and very rarely cases of maxil and, occasionally, a red eye. The localised pain is well lary herpes zoster,l affecting many of the tissues of the known to precede the rash by several days in some cases. globe and orbit by highly varied types of lesions. This probably represents the replication and migration We felt it would be helpful to report our experience with phase of the disease and is possibly accompanied by a lim the disease because the large number of cases we have ited viraemia. -
Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate. -
Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study
Cornea Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study Patricia Gallego-Munoz,˜ 1 Luc´ıa Ibares-Fr´ıas,1 Elvira Lorenzo,1 Susana Marcos,2 Pablo Perez-Merino,´ 2 Nandor Bekesi,2 Irene E. Kochevar,3 and M. Carmen Mart´ınez-Garc´ıa1 1Departamento de Biolog´ıa Celular, Histolog´ıa y Farmacolog´ıa, GIR de Tecnicas´ Opticas´ para el Diagnostico,´ Universidad de Valladolid, Valladolid, Spain 2Instituto de Optica,´ Consejo Superior de Investigaciones Cient´ıficas, Madrid, Spain 3Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States Correspondence: M. Carmen PURPOSE. To evaluate corneal wound healing after treatment with a new collagen crosslinking Mart´ınez-Garc´ıa, Departamento de protocol using rose bengal dye and green light (RGX). Biolog´ıa Celular, Histolog´ıa y Farm- acolog´ıa, Facultad de Medicina, Uni- METHODS. One cornea of 20 New Zealand rabbits was de-epithelialized (DE) in an 8-mm versidad de Valladolid, C/Ramon´ y diameter circle and, in another group (n ¼ 25), the DE corneas were then stained with 0.1% Cajal 7, 47005 Valladolid, Spain; rose bengal for 2 minutes and exposed to green light (532 nm) for 7 minutes (RGX). The mariacarmen.martinez.garcia@ contralateral eyes without treatment acted as controls. The animals were clinically followed uva.es. including fluorescein staining and pachymetry. Healing events were analyzed after euthanasia 0 Submitted: December 23, 2016 at 2, 30, and 60 days. Cell death (TUNEL assay), cell proliferation (5-bromo-2 -deoxyuridine Accepted: June 1, 2017 incorporation), and cell differentiation to myofibroblasts (a-SMA labeling) were carried out. -
Curable Composition and Skin Adhesive
(19) TZZ ¥Z¥_T (11) EP 2 957 303 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 23.12.2015 Bulletin 2015/52 A61L 15/58 (2006.01) A61L 24/04 (2006.01) C08K 5/10 (2006.01) C09J 167/06 (2006.01) (2006.01) (21) Application number: 14173247.9 C08L 67/06 (22) Date of filing: 20.06.2014 (84) Designated Contracting States: (72) Inventor: Schüwer, Nicolas AL AT BE BG CH CY CZ DE DK EE ES FI FR GB 1010 Lausanne (CH) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (74) Representative: Hoffmann Eitle Designated Extension States: Patent- und Rechtsanwälte PartmbB BA ME Arabellastraße 30 81925 München (DE) (71) Applicant: NITTO DENKO CORPORATION Osaka 567 (JP) (54) Curable composition and skin adhesive (57) The present invention pertains to compositions The composition of the invention may be cross- linked to containing a polycondensate and optionally an oil com- yield an adhesive composition. The composition of the ponent, wherein the polycondensate is derived from a invention and the adhesive composition of the invention dicarboxylic acid component, a diol component and an may be used on substrates such as tapes and patches ethylenically unsaturated dicarboxylic acid component. in the medical field. EP 2 957 303 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 957 303 A1 Description 1. Technical Field of the Invention 5 [0001] The present invention relates to a curable composition comprising: a polycondensate of a dicarboxylic acid, a diol, and a polymerizable ethylenic derivative; and optionally an oil additive. -
Medications in Pregnant and Nursing Mothers
Medications in Pregnant and Nursing Mothers NADINE M. GIRGIS, OD, FAAO ASSISTANT PROFESSOR YIN C. TEA, OD, FAAO CHIEF, PEDIATRICS AND BINOCULAR VISION ASSISTANT PROFESSOR Gestation age vs fetal age Gestation age-sperm penetrates the egg and zygote is formed Zygote (fertilized egg) travels from fallopian tube to uterus During this time, egg divides into cells - called a morula Continued dividing and morula - called a blastocyst - embeds in the uterus anywhere from 6-12 days after conception This begins the embryonic stage and fetal age begins Fetal development-1st trimester Gestation age week 3-fetal age week 1: a lot of basic growth Brain, spinal cord, heart, GI tract begin development 1st trimester Gestation age-week 4 and 5: embryo ¼ inch long Arm and leg buds, ears, eyes forming Placenta forming and producing hormones Heart is beating at a steady rhythm Movement of rudimentary blood through blood vessels 1st trimester Gestation age week 6: embryo is ½ in length Lungs, jaw, nose, plate formation, hands and feet Hand and feet buds have webbed structures Brain forming into complex parts 1st trimester Gestation age week 7: weighs less than an aspirin All essential organs have begun to form Hair, nail follicles, eyelids and tongue starting to form Trunk begins to straighten out 1st trimester Gestation age week 8: 1 in long, size of a bean All parts of adult are now present in the embryo Bones beginning to form Muscles begin to contract Facial features, including eyelids more developed Gestation age weeks 9-13: 3 in and weighs -
Waste Disposal Guide
Waste Disposal Guide How to Properly Dispose of Waste Materials Generated at Michigan State University Environmental Health & Safety (EHS) / Office of Radiation, Chemical & Biological Safety (ORCBS) C124 Research Complex‐Engineering East Lansing, MI 48824‐1326 Revised April 2009 CONTACT INFORMATION Campus Emergency: 911 ORCBS Phone Number: (517) 355-0153 ORCBS Fax Number: (517) 353-4871 ORCBS E-mail Address: [email protected] ORCBS Web Address: http://www.orcbs.msu.edu TABLE OF CONTENTS Sections Introduction ................................................................................................................... 4 Hazardous Waste Defined ............................................................................................ 5 Requirements for Chemical Waste ............................................................................... 6 Classification of Chemical Waste .................................................................................. 7 Containers ..................................................................................................................... 8 Container Label ............................................................................................................. 9 General Labeling & Packaging Procedures .................................................................. 9 Specific Labeling & Packaging Procedures ............................................................. 9-15 Scheduling a Chemical Waste Pick-up ...................................................................... -
Inhibition of Vesicular Glutamate Storage and Exocytotic Release by Rose Bengal
Journal of Neurochemistry, 2001, 77,34±42 Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal Kiyokazu Ogita,*,1 Koji Hirata,* David G. Bole,* Sumiko Yoshida,*,2 Yutaka Tamura,*,3 Anne Marie Leckenby* and Tetsufumi Ueda*,²,³ *Mental Health Research Institute, Departments of ²Pharmacology and ³Psychiatry, Medical School, The University of Michigan, Ann Arbor, Michigan, USA Abstract the synaptosome result in a corresponding decrease in the It had been thought that quantal size in synaptic transmission amount of [3H]Glu released in a depolarization- (induced by 4- is invariable. Evidence has been emerging, however, that aminopyridine) and Ca21-dependent manner. In contrast, quantal size can be varied under certain conditions. We ¯uorescein, the halogen-free analog of Rose Bengal, which is 3 3 present evidence that alteration in vesicular [ H]L-glutamate devoid of inhibitory activity on vesicular [ H]Glu uptake, failed to (Glu) content within the synaptosome (a pinched-off nerve change the amount of exocytotically released [3H]Glu. These ending preparation) leads to a change in the amount of observations suggest that glutamate synaptic transmission exocytotically released [3H]Glu. We found that Rose Bengal, a could be altered by pharmacological intervention of glutamate polyhalogenated ¯uorescein derivative, is a quite potent uptake into synaptic vesicles in the nerve terminal, a new membrane-permeant inhibitor (K 19 nM) of glutamate mode of synaptic manipulation for glutamate transmission. i uptake into isolated synaptic vesicles. This vesicular Glu Keywords: glutamate, inhibitor, release, Rose Bengal, uptake inhibition was achieved largely without affecting H1- vesicular uptake. pump ATPase. We show that various degrees of reduction J. -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0 -
2020 Aetna Standard Plan
Plan for your best health Aetna Standard Plan Aetna.com Aetna is the brand name used for products and services provided by one or more of the Aetna group of subsidiary companies, including Aetna Life Insurance Company and its affiliates (Aetna). Aetna Pharmacy Management refers to an internal business unit of Aetna Health Management, LLC. Aetna Pharmacy Management administers, but does not offer, insure or otherwise underwrite the prescription drug benefits portion of your health plan and has no financial responsibility therefor. 2020 Pharmacy Drug Guide - Aetna Standard Plan Table of Contents INFORMATIONAL SECTION..................................................................................................................6 *ADHD/ANTI-NARCOLEPSY/ANTI-OBESITY/ANOREXIANTS* - DRUGS FOR THE NERVOUS SYSTEM.................................................................................................................................16 *ALLERGENIC EXTRACTS/BIOLOGICALS MISC* - BIOLOGICAL AGENTS...............................18 *ALTERNATIVE MEDICINES* - VITAMINS AND MINERALS....................................................... 19 *AMEBICIDES* - DRUGS FOR INFECTIONS.....................................................................................19 *AMINOGLYCOSIDES* - DRUGS FOR INFECTIONS.......................................................................19 *ANALGESICS - ANTI-INFLAMMATORY* - DRUGS FOR PAIN AND FEVER............................19 *ANALGESICS - NONNARCOTIC* - DRUGS FOR PAIN AND FEVER......................................... -
31295001608727.Pdf
MOLECULAR TOPOGRAPHY AND FUNCTION OF PERIDININ IN THE PERIDININ-CHLOROPHYLL a-PROTEIN COMPLEX by SIVARAMAKRISHNA PRASAD KOKA, B.S., M.A. A DISSERTATION IN CHEMISTRY Submitted to the Graduate Faculty of Texas Tech University in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY Approved _ Accepted December, 1977 Ho, 7^ ACKNOWLEDGMENTS I am extremely grateful and deeply indebted to my professor. Dr. Pill-Soon Song, for his constant guidance, patience and encouragement throughout my studies for the Ph.D. degree. I am thankful to my fellow graduate stu dents for their help and cooperation. The efficient typing work of Mrs. Evelyn Gaffga is well acknowledged. I continue to be grateful to my former professors, Dr. Robert R. Kuntz (University of Missouri) and Dr. Richard D. Doepker (University of Miami), without whose encourage ment I would not be where I am now. Last but not the least, my indebtedness persists forever to my parents and family, without whose help I would not have been able to pursue higher studies. XI TABLE OF CONTENTS ACKNOWLEDGrffiNTS ii LIST OF TABLES vi LIST OF ILLUSTRATIONS vii I. INTRODUCTION AND STATEI/IENT OF PROBLEM. ... 1 Introduction 1 Statement of Problem 2 II. LITERATURE REVIEW 3 Carotenoid-Chlorophyll Complexes . 3 Energy Transfer from Carotenoid to Chlorophyll 9 Exciton Interactions 12 Role of Carotenoid As A Photoreceptor 13 Singlet Oxygen-Induced Photo- oxidation and Its Inhibition ... 14 Singlet-Triplet Transitions of Photosensitizer Dyes 21 III. MATERIALS AND METHODS 22 Materials 22 Methods 24 Theoretical Section 24 Critical Distance Calculation. 24 iii IV Intermolecular Distance Cal culation 25 Polarization by Photoselection.