Forever Young? Life Extension and the Ageing Mind
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Excesss Karaoke Master by Artist
XS Master by ARTIST Artist Song Title Artist Song Title (hed) Planet Earth Bartender TOOTIMETOOTIMETOOTIM ? & The Mysterians 96 Tears E 10 Years Beautiful UGH! Wasteland 1999 Man United Squad Lift It High (All About 10,000 Maniacs Candy Everybody Wants Belief) More Than This 2 Chainz Bigger Than You (feat. Drake & Quavo) [clean] Trouble Me I'm Different 100 Proof Aged In Soul Somebody's Been Sleeping I'm Different (explicit) 10cc Donna 2 Chainz & Chris Brown Countdown Dreadlock Holiday 2 Chainz & Kendrick Fuckin' Problems I'm Mandy Fly Me Lamar I'm Not In Love 2 Chainz & Pharrell Feds Watching (explicit) Rubber Bullets 2 Chainz feat Drake No Lie (explicit) Things We Do For Love, 2 Chainz feat Kanye West Birthday Song (explicit) The 2 Evisa Oh La La La Wall Street Shuffle 2 Live Crew Do Wah Diddy Diddy 112 Dance With Me Me So Horny It's Over Now We Want Some Pussy Peaches & Cream 2 Pac California Love U Already Know Changes 112 feat Mase Puff Daddy Only You & Notorious B.I.G. Dear Mama 12 Gauge Dunkie Butt I Get Around 12 Stones We Are One Thugz Mansion 1910 Fruitgum Co. Simon Says Until The End Of Time 1975, The Chocolate 2 Pistols & Ray J You Know Me City, The 2 Pistols & T-Pain & Tay She Got It Dizm Girls (clean) 2 Unlimited No Limits If You're Too Shy (Let Me Know) 20 Fingers Short Dick Man If You're Too Shy (Let Me 21 Savage & Offset &Metro Ghostface Killers Know) Boomin & Travis Scott It's Not Living (If It's Not 21st Century Girls 21st Century Girls With You 2am Club Too Fucked Up To Call It's Not Living (If It's Not 2AM Club Not -
The Ageing Haematopoietic Stem Cell Compartment
REVIEWS The ageing haematopoietic stem cell compartment Hartmut Geiger1,2, Gerald de Haan3 and M. Carolina Florian1 Abstract | Stem cell ageing underlies the ageing of tissues, especially those with a high cellular turnover. There is growing evidence that the ageing of the immune system is initiated at the very top of the haematopoietic hierarchy and that the ageing of haematopoietic stem cells (HSCs) directly contributes to changes in the immune system, referred to as immunosenescence. In this Review, we summarize the phenotypes of ageing HSCs and discuss how the cell-intrinsic and cell-extrinsic mechanisms of HSC ageing might promote immunosenescence. Stem cell ageing has long been considered to be irreversible. However, recent findings indicate that several molecular pathways could be targeted to rejuvenate HSCs and thus to reverse some aspects of immunosenescence. HSC niche The current demographic shift towards an ageing popu- The innate immune system is also affected by ageing. A specialized lation is an unprecedented global phenomenon that has Although an increase in the number of myeloid precur- microenvironment that profound implications. Ageing is associated with tissue sors has been described in the bone marrow of elderly interacts with haematopoietic attrition and an increased incidence of many types of can- people, the oxidative burst and the phagocytic capacity of stem cells (HSCs) to regulate cers, including both myeloid and lymphoid leukaemias, and both macrophages and neutrophils are decreased in these their fate. other haematopoietic cell malignancies1,2. Thus, we need individuals12,13. Moreover, the levels of soluble immune to understand the molecular and cellular mechanisms of mediators are altered with ageing. -
Chapter 6: Old People Are People Too, So Let's Act
Career Planning & Adult Development JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Helen Harkness, Guest Editor QThe Future Q The End of Work as We Know It QJobs and Careers on the Front Line of the Future QSilicon Valley and the New Rules of Work Q Training Challenges Facing Education and Training and Career Development in the Future QOld people are people too, so let’s act accordingly Q Crisis of Human Capital in Aerospace: It’s All About the STEM QCollege for All – Reality or Flawed Myth? QOur Jobs: The American Workforce and Economy in Crisis Q The Future Has Arrived: The Future is Now the Present Summer 2015..............................Career Planning and Adult Development JOURNAL..............................1 CAREER PLANNING and ADULT DEVELOPMENT JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Looking Ahead with the Journal,E\Steven E. Beasley, Managing Editor4 Introduction to this Issue, E\ Helen Harkness, PhD, Guest Editor5 Chapter 1: 7KH)XWXUHE\ Leigh Ellen Key8 Chapter 2: 7KH(QGRI:RUNDV:H.QRZ,Wby Andy Hines10 Chapter 3: -REVDQG&DUHHUVRQWKH)URQW/LQHRIWKH)XWXUHby Gary Marx20 Chapter 4: 6LOLFRQ9DOOH\DQGWKH1HZ5XOHVRI:RUNE\Gary A. Bolles28 Chapter 5: 7UDLQLQJ&KDOOHQJHV)DFLQJ(GXFDWLRQDQG7UDLQLQJ DQG&DUHHU'HYHORSPHQWLQWKH)XWXUHE\Timothy C. Mack40 Chapter 6: 2OGSHRSOHDUHSHRSOHWRRVROHW·VDFWDFFRUGLQJO\by Aubrey de Grey47 Chapter 7: &ULVLVRI+XPDQ&DSLWDOLQ$HURVSDFH,W·V$OO$ERXWWKH67(0 by Deborah Westphal51 Chapter 8: &ROOHJHIRU$OO²5HDOLW\RU)ODZHG0\WK"E\ -
Aster Marketing Thesi
ERASMUS SCHOOL OF ECONOMICS DEPARTMENT OF BUSINESS ECONOMICS - MARKETING MASTER THESIS It's All in the Lyrics: The Predictive Power of Lyrics Date : August, 2014 Name : Maarten de Vos Student ID : 331082 Supervisor : Dr. F. Deutzmann Abstract: This research focuses on whether it is possible to determine popularity of a specific song based on its lyrics. The songs which were considered were in the US Billboard Top 40 Singles Chart between 2006 and 2011. From this point forward, k-means clustering in RapidMiner has been used to determine the content that was present in the songs. Furthermore, data from Last.FM was used to determine the popularity of a song. This resulted in the conclusion that up to a certain extent, it is possible to determine popularity of songs. This is mostly applicable to the love theme, but only in the specific niches of it. Keywords: Content analysis, RapidMiner, Lyric analysis, Last.FM, K-means clustering, US Billboard Top 40 Singles Chart, Popularity 1 Table of Contents 1. Introduction ..................................................................................................................................... 4 2. Motivation ........................................................................................................................................ 5 2.1. Academic contribution .............................................................................................................. 5 2.2. Managerial contribution .......................................................................................................... -
Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes
Sound Decisions: An Undergraduate Bioethics Journal Volume 2 Issue 1 Article 4 2016-12-15 Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes Eric Ralph University of Puget Sound Follow this and additional works at: https://soundideas.pugetsound.edu/sounddecisions Part of the Bioethics and Medical Ethics Commons Recommended Citation Ralph, Eric (2016) "Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes," Sound Decisions: An Undergraduate Bioethics Journal: Vol. 2 : Iss. 1 , Article 4. Available at: https://soundideas.pugetsound.edu/sounddecisions/vol2/iss1/4 This Article is brought to you for free and open access by the Student Publications at Sound Ideas. It has been accepted for inclusion in Sound Decisions: An Undergraduate Bioethics Journal by an authorized editor of Sound Ideas. For more information, please contact [email protected]. Ralph: Longevity Extension Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes Eric Ralph Introduction In the last several decades, a significant amount of progress has been made in pursuits to better understand the process of aging and subsequently gain some level of control over it. Current theories of aging are admittedly lacking, but this has not prevented biogerontologists from drastically increasing the longevity of yeast, drosophilae, worms, and mice (Vaiserman, Moskalev, & Pasyukova 2015; Tosato, Zamboni et al. 2007; Riera & Dillin 2015). Wide-ranging successes with gene therapy and increased comprehension of the genetic components of aging have also recently culminated in numerous successes in extending the longevity of animals and the first human trial of a gene therapy to extend life through telomerase manipulation is already underway, albeit on a small scale (Mendell et al. -
Worms Under Stress: Unravelling Genetic Complex Traits Through Perturbation
Worms under stress: unravelling genetic complex traits through perturbation Miriam Rodriguez Sanchez Thesis committee Promotor Prof. Dr Jaap Bakker Professor of Nematology Wageningen University Co-promotor Dr Jan E. Kammenga Associate professor, Laboratory of Nematology Wageningen University Other members Prof. Dr Bas J. Zwaan, Wageningen University Prof. Dr Hendrik.C. Korswagen, Hubrecht Institute, Utrecht Prof. Dr Ellen Nollen, European Research Institute for the Biology of Ageing (ERIBA), Groningen Dr Gino B. Poulin, University of Manchester, United Kingdom This research was conducted under the auspices of the Graduate School of Production Ecology and Resource Conservation (PE&RC). Worms under stress: unravelling genetic complex traits through perturbation Miriam Rodriguez Sanchez Thesis submitted in fulfilment of the requirements for the degree of doctor at Wageningen University by the authority of the Rector Magnificus Prof. dr. M.J. Kropff, in the presence of the Thesis Committee appointed by the Academic Board to be defended in public on Friday 14 March 2014 at 11 a.m. in the Aula. Miriam Rodriguez Sanchez Worms under stress: unravelling genetic complex traits through perturbation 130 pages PhD thesis, Wageningen University, Wageningen, NL (2014) With references, with summaries in Dutch and English ISBN: 978-94-6173-851-6 A mi padre CONTENTS Contents Chapter 1 General Introduction ........................................................................... 3 Chapter 2 C. elegans stress response and its relevance to complex human disease and aging ................................................. 15 Chapter 3 Uncovering genotype specific variation of Wnt signaling in C. elegans .................................................................... 33 Chapter 4 Genetic variation for stress-response hormesis in C. elegans life span ......................................................................... 55 Chapter 5 Molecular confirmation of trans-regulatory eQTL in C. -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
Read Our New Annual Report
The seeds of a concept. The roots of an idea. The potential of a world free of age-related disease. Photo: Sherry Loeser Photography SENS Research Foundation Board of Directors Barbara Logan, Chair Bill Liao, Secretary Kevin Perrott, Treasurer Michael Boocher Jonathan Cain Kevin Dewalt Michael Kope Jim O’Neill Frank Schüler Sherry Loeser Photography 2 Contents CEO Letter (Jim O’Neill) 4 Finances 5 Donors 6 - 7 Fundraising & Conferences 8 - 9 Around the World with Aubrey de Grey 10 Outreach 11 Founding CEO Tribute & Underdog Pharmaceuticals 12 - 13 Investments 14 Welcome New Team Members 15 Education 16 - 17 Publications & Research Advisory Board 18 Research Summaries 19 - 22 Ways to Donate 23 The SRF Team Front row: Anne Corwin (Engineer/Editor), Amutha Boominathan (MitoSENS Group Lead), Alexandra Stolzing (VP of Research), Aubrey de Grey (Chief Science Officer), Jim O’Neill (CEO), Bhavna Dixit (Research Associate). Center row: Caitlin Lewis (Research Associate), Lisa Fabiny-Kiser (VP of Operations), Gary Abramson (Graphics), Maria Entraigues-Abramson (Global Outreach Coordinator), Jessica Lubke (Administrative Assistant). Back row: Tesfahun Dessale Admasu (Research Fellow), Amit Sharma (ImmunoSENS Group Lead), Michael Rae (Science Writer), Kelly Protzman (Executive Assistant). Not Pictured: Greg Chin (Director, SRF Education), Ben Zealley (Website/Research Assistant/ Deputy Editor) Photo: Sherry Loeser Photography, 2019 3 From the CEO At our 2013 conference at Queens College, Cambridge, I closed my talk by saying, “We should not rest until we make aging an absurdity.” We are now in a very different place. After a lot of patient explanation, publication of scientific results, conferences, and time, our community persuaded enough scientists of the feasibility of the damage repair approach to move SENS and SENS Research Foundation from the fringes of scientific respectability to the vanguard of a mainstream community of scientists developing medical therapies to tackle human aging. -
8123 Songs, 21 Days, 63.83 GB
Page 1 of 247 Music 8123 songs, 21 days, 63.83 GB Name Artist The A Team Ed Sheeran A-List (Radio Edit) XMIXR Sisqo feat. Waka Flocka Flame A.D.I.D.A.S. (Clean Edit) Killer Mike ft Big Boi Aaroma (Bonus Version) Pru About A Girl The Academy Is... About The Money (Radio Edit) XMIXR T.I. feat. Young Thug About The Money (Remix) (Radio Edit) XMIXR T.I. feat. Young Thug, Lil Wayne & Jeezy About Us [Pop Edit] Brooke Hogan ft. Paul Wall Absolute Zero (Radio Edit) XMIXR Stone Sour Absolutely (Story Of A Girl) Ninedays Absolution Calling (Radio Edit) XMIXR Incubus Acapella Karmin Acapella Kelis Acapella (Radio Edit) XMIXR Karmin Accidentally in Love Counting Crows According To You (Top 40 Edit) Orianthi Act Right (Promo Only Clean Edit) Yo Gotti Feat. Young Jeezy & YG Act Right (Radio Edit) XMIXR Yo Gotti ft Jeezy & YG Actin Crazy (Radio Edit) XMIXR Action Bronson Actin' Up (Clean) Wale & Meek Mill f./French Montana Actin' Up (Radio Edit) XMIXR Wale & Meek Mill ft French Montana Action Man Hafdís Huld Addicted Ace Young Addicted Enrique Iglsias Addicted Saving abel Addicted Simple Plan Addicted To Bass Puretone Addicted To Pain (Radio Edit) XMIXR Alter Bridge Addicted To You (Radio Edit) XMIXR Avicii Addiction Ryan Leslie Feat. Cassie & Fabolous Music Page 2 of 247 Name Artist Addresses (Radio Edit) XMIXR T.I. Adore You (Radio Edit) XMIXR Miley Cyrus Adorn Miguel Adorn Miguel Adorn (Radio Edit) XMIXR Miguel Adorn (Remix) Miguel f./Wiz Khalifa Adorn (Remix) (Radio Edit) XMIXR Miguel ft Wiz Khalifa Adrenaline (Radio Edit) XMIXR Shinedown Adrienne Calling, The Adult Swim (Radio Edit) XMIXR DJ Spinking feat. -
Songs by Title
16,341 (11-2020) (Title-Artist) Songs by Title 16,341 (11-2020) (Title-Artist) Title Artist Title Artist (I Wanna Be) Your Adams, Bryan (Medley) Little Ole Cuddy, Shawn Underwear Wine Drinker Me & (Medley) 70's Estefan, Gloria Welcome Home & 'Moment' (Part 3) Walk Right Back (Medley) Abba 2017 De Toppers, The (Medley) Maggie May Stewart, Rod (Medley) Are You Jackson, Alan & Hot Legs & Da Ya Washed In The Blood Think I'm Sexy & I'll Fly Away (Medley) Pure Love De Toppers, The (Medley) Beatles Darin, Bobby (Medley) Queen (Part De Toppers, The (Live Remix) 2) (Medley) Bohemian Queen (Medley) Rhythm Is Estefan, Gloria & Rhapsody & Killer Gonna Get You & 1- Miami Sound Queen & The March 2-3 Machine Of The Black Queen (Medley) Rick Astley De Toppers, The (Live) (Medley) Secrets Mud (Medley) Burning Survivor That You Keep & Cat Heart & Eye Of The Crept In & Tiger Feet Tiger (Down 3 (Medley) Stand By Wynette, Tammy Semitones) Your Man & D-I-V-O- (Medley) Charley English, Michael R-C-E Pride (Medley) Stars Stars On 45 (Medley) Elton John De Toppers, The Sisters (Andrews (Medley) Full Monty (Duets) Williams, Sisters) Robbie & Tom Jones (Medley) Tainted Pussycat Dolls (Medley) Generation Dalida Love + Where Did 78 (French) Our Love Go (Medley) George De Toppers, The (Medley) Teddy Bear Richard, Cliff Michael, Wham (Live) & Too Much (Medley) Give Me Benson, George (Medley) Trini Lopez De Toppers, The The Night & Never (Live) Give Up On A Good (Medley) We Love De Toppers, The Thing The 90 S (Medley) Gold & Only Spandau Ballet (Medley) Y.M.C.A. -
2 the Biology of Ageing
The biology of ageing 2 Aprimer JOAO˜ PEDRO DE MAGALHAES˜ OVERVIEW .......................................................... This chapter introduces key biological concepts of ageing. First, it defines ageing and presents the main features of human ageing, followed by a consideration of evolutionary models of ageing. Causes of variation in ageing (genetic and dietary) are reviewed, before examining biological theories of the causes of ageing. .......................................................... Introduction Thanks to technological progress in different areas, including biomed- ical breakthroughs in preventing and treating infectious diseases, longevity has been increasing dramatically for decades. The life expectancy at birth in the UK for boys and girls rose, respectively, from 45 and 49 years in 1901 to 75 and 80 in 1999 with similar fig- ures reported for other industrialized nations (see Chapter 1 for further discussion). A direct consequence is a steady increase in the propor- tion of people living to an age where their health and well-being are restricted by ageing. By the year 2050, it is estimated that the per- centage of people in the UK over the age of 65 will rise to over 25 per cent, compared to 14 per cent in 2004 (Smith, 2004). The greying of the population, discussed elsewhere (see Chapter 1), implies major medical and societal changes. Although ageing is no longer considered by health professionals as a direct cause of death (Hayflick, 1994), the major killers in industrialized nations are now age-related diseases like cancer, diseases of the heart and 22 Joao˜ Pedro de Magalhaes˜ neurodegenerative diseases. The study of the biological mechanisms of ageing is thus not merely a topic of scientific curiosity, but a crucial area of research throughout the twenty-first century. -
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2007 RECAP 1st Quarter 2008 • Volume 29:1 2007 ANnual Review page 5 Member Profile: Wes Du Charme page 3 7th Alcor Conference Recap page 13 Cryonics and Religion: Friends or Foes? page 19 INSIDE CRYONICS 2 From the Editor 1ST QUARTER 2008 • VOLUME 29:1 19 Cryonics and Religion: Friends or Foes? The cryonics community recognizes the importance and challenge of being 1st Quarter 2008 • Volume 29:1 understood by the general 2007 RECAP public. Religion plays a sub- Cover shows opening reception stantial role in our diverse at the 7th Alcor conference. 2007 ANnual society and may seem to Review Photo by Brian Harris. page 5 some to be at odds with many facets of scientific COVER STORY: PAGE 5 advancement. Meet one theologian who feels the 2007 Annual Review: Today, over ultimate success of cryonics 850page people 3 in the world rely on the is contingent upon the sup- Member Profile: Wes Du CharmeAlcor Life Extension Foundation for Recap port of more than just great Conferencecryopreservation page 13 services. Enrich your 7th Alcor scientific minds. understanding of present-day clinical advancements with the potential to CryonicsFriends and Religion: or Foes?page 19 significantly benefit Alcor’s growing 22 Book Review: Ending membership base in years to come. Aging Likened to a good detective novel, Ending Aging allures the reader into a real- life tale of the mysteries of aging. The author, Dr. 3 Member Profile: Wes Du Charme Aubrey de Grey, has been Wes Du Charme – psychologist, author and barber shop quartet the center of controversy singer – celebrates his thirteenth year as an Alcor member in since proposing a systematic June 2008.