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Problem Formulation of the Risk Evaluation for Perchloroethylene (Ethene, 1,1,2,2-Tetrachloro)
EPA Document# EPA-740-R1-7017 May 2018 DRAFTUnited States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention Problem Formulation of the Risk Evaluation for Perchloroethylene (Ethene, 1,1,2,2-Tetrachloro) CASRN: 127-18-4 May 2018 TABLE OF CONTENTS ABBREVIATIONS ............................................................................................................................ 8 EXECUTIVE SUMMARY .............................................................................................................. 11 1 INTRODUCTION .................................................................................................................... 14 1.1 Regulatory History ..................................................................................................................... 16 1.2 Assessment History .................................................................................................................... 16 1.3 Data and Information Collection ................................................................................................ 18 1.4 Data Screening During Problem Formulation ............................................................................ 19 2 PROBLEM FORMULATION ................................................................................................. 20 2.1 Physical and Chemical Properties .............................................................................................. 20 2.2 Conditions of Use ...................................................................................................................... -
Toxicological Profile for Tetrachloroethylene
TETRACHLOROETHYLENE 263 6. POTENTIAL FOR HUMAN EXPOSURE 6.1 OVERVIEW Tetrachloroethylene has been identified in at least 949 of the 1,854 hazardous waste sites that have been proposed for inclusion on the EPA National Priorities List (NPL) (ATSDR 2017a). However, the number of sites evaluated for tetrachloroethylene is not known. The frequency of these sites can be seen in Figure 6-1. Of these sites, 943 are located within the United States, 3 are located in the Commonwealth of Puerto Rico (not shown), 1 is located in Guam (not shown), and 1 is located in the Virgin Islands (not shown). Tetrachloroethylene is a VOC that is widely distributed in the environment. It is released to the environment via industrial emissions and from building and consumer products. Releases are primarily to the atmosphere. However, the compound is also released to surface water and land in sewage sludges and in other liquid and solid waste, where its high vapor pressure and Henry's law constant usually result in its rapid volatilization to the atmosphere. Tetrachloroethylene has relatively low solubility in water and has medium-to-high mobility in soil; thus, its residence time in surface environments is not expected to be more than a few days. However, it persists in the atmosphere for several months and can last for decades in the groundwater. Background tetrachloroethylene levels in outdoor air are typically <1 μg/m3 (0.15 ppb) for most locations (EPA 2013h, 2018); however, indoor air at source dominant facilities (e.g., dry cleaners) has been shown to have levels >1 mg/m3 (Chiappini et al. -
Secondary Organic Aerosol from Chlorine-Initiated Oxidation of Isoprene Dongyu S
Secondary organic aerosol from chlorine-initiated oxidation of isoprene Dongyu S. Wang and Lea Hildebrandt Ruiz McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78756, USA 5 Correspondence to: Lea Hildebrandt Ruiz ([email protected]) Abstract. Recent studies have found concentrations of reactive chlorine species to be higher than expected, suggesting that atmospheric chlorine chemistry is more extensive than previously thought. Chlorine radicals can interact with HOx radicals and nitrogen oxides (NOx) to alter the oxidative capacity of the atmosphere. They are known to rapidly oxidize a wide range of volatile organic compounds (VOC) found in the atmosphere, yet little is known about secondary organic aerosol (SOA) 10 formation from chlorine-initiated photo-oxidation and its atmospheric implications. Environmental chamber experiments were carried out under low-NOx conditions with isoprene and chlorine as primary VOC and oxidant sources. Upon complete isoprene consumption, observed SOA yields ranged from 8 to 36 %, decreasing with extended photo-oxidation and SOA aging. Formation of particulate organochloride was observed. A High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer was used to determine the molecular composition of gas-phase species using iodide-water and hydronium-water 15 cluster ionization. Multi-generational chemistry was observed, including ions consistent with hydroperoxides, chloroalkyl hydroperoxides, isoprene-derived epoxydiol (IEPOX) and hypochlorous acid (HOCl), evident of secondary OH production and resulting chemistry from Cl-initiated reactions. This is the first reported study of SOA formation from chlorine-initiated oxidation of isoprene. Results suggest that tropospheric chlorine chemistry could contribute significantly to organic aerosol loading. -
Health Effects Support Document for Hexachlorobutadiene Health Effects Support Document for Hexachlorobutadiene
Health Effects Support Document for Hexachlorobutadiene Health Effects Support Document for Hexachlorobutadiene U.S. Environmental Protection Agency Office of Water (4304T) Health and Ecological Criteria Division Washington, DC 20460 www.epa.gov/safewater/ EPA 822-R-03-002 February 2003 Printed on Recycled Paper FOREWORD The Safe Drinking Water Act (SDWA), as amended in 1996, requires the Administrator of the Environmental Protection Agency (EPA) to establish a list of contaminants to aid the agency in regulatory priority setting for the drinking water program. In addition, SDWA requires EPA to make regulatory determinations for no fewer than five contaminants by August 2001. The criteria used to determine whether or not to regulate a chemical on the CCL are the following: The contaminant may have an adverse effect on the health of persons. The contaminant is known to occur or there is a substantial likelihood that the contaminant will occur in public water systems with a frequency and at levels of public health concern. In the sole judgment of the administrator, regulation of such contaminant presents a meaningful opportunity for health risk reduction for persons served by public water systems. The Agency’s findings for the three criteria are used in making a determination to regulate a contaminant. The Agency may determine that there is no need for regulation when a contaminant fails to meet one of the criteria. This document provides the health effects basis for the regulatory determination for hexachlorobutadiene. In arriving at the regulatory determination, data on toxicokinetics, human exposure, acute and chronic toxicity to animals and humans, epidemiology, and mechanisms of toxicity were evaluated. -
1,2-DICHLOROETHANE 1. Exposure Data
1,2-DICHLOROETHANE Data were last reviewed in IARC (1979) and the compound was classified in IARC Monographs Supplement 7 (1987a). 1. Exposure Data 1.1 Chemical and physical data 1.1.1 Nomenclature Chem. Abstr. Serv. Reg. No.: 107-06-2 Chem. Abstr. Name: 1,2-Dichloroethane IUPAC Systematic Name: 1,2-Dichloroethane Synonym: Ethylene dichloride 1.1.2 Structural and molecular formulae and relative molecular mass Cl CH2 CH2 Cl C2H4Cl2 Relative molecular mass: 98.96 1.1.3 Chemical and physical properties of the pure substance (a) Description: Colourless liquid with a pleasant odour (Budavari, 1996) (b) Boiling-point: 83.5°C (Lide, 1995) (c) Melting-point: –35.5°C (Lide, 1995) (d) Solubility: Slightly soluble in water; miscible with ethanol, chloroform and diethyl ether (Lide, 1995; Budavari, 1996) (e) Vapour pressure: 8 kPa at 20°C (Verschueren, 1996) (f) Flash-point: 18°C, open cup (Budavari, 1996) (g) Conversion factor: mg/m3 = 4.0 × ppm 1.2 Production and use World production capacities in 1988 for 1,2-dichloroethane have been reported as follows (thousand tonnes): North America, 9445; western Europe, 9830; Japan, 3068; and other, 8351 (Snedecor, 1993). Production in the United States has been reported as follows (thousand tonnes): 1983, 5200; 1990, 6300; 1991, 6200; 1992, 6900; 1993, 8100 (United States National Library of Medicine, 1997). The total annual production in Canada in 1990 was estimated to be 922 thousand tonnes; more than 1000 thousand tonnes were produced in the United Kingdom in 1991 (WHO, 1995). –501– 502 IARC MONOGRAPHS VOLUME 71 1,2-Dichloroethane is used primarily in the production of vinyl chloride; 99% of total demand in Canada, 90% in Japan and 88% of total production in the United States are used for this purpose. -
Removal of AOX in Activated Sludge of Industrial Chemical Dyestuff with Bimetallic Pd/Fe Particles
water Article Removal of AOX in Activated Sludge of Industrial Chemical Dyestuff with Bimetallic Pd/Fe Particles Cancan Xu 1, Rui Liu 1, Wei Zheng 1,*, Lichu Lin 1 and Lvjun Chen 1,2 1 Zhejiang Provincial Key Laboratory of Water Science and Technology, Department of Environment in Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China; [email protected] (C.X.); [email protected] (R.L.); sifl[email protected] (L.L.); [email protected] (L.C.) 2 School of Environment, Tsinghua University, Beijing 100084, China * Correspondence: [email protected]; Tel.: +86-0573-8258-1603 Abstract: Pd/Fe bimetallic particles were synthesized by chemical deposition and used to remove absorbable organic halogens (AOX) in the activated sludge of a chemical dyestuff wastewater treatment plant. Bath experiments demonstrated that the Pd/Fe bimetallic particles could effectively remove AOX. It indicated several factors, such as Pd loading, the amount of Pd/Fe used, initial activated sludge pH, and reaction time, which could affect the removal effect. The results showed that increasing the Pd content in Pd/Fe particles, from 0.01 to 0.05 wt %, significantly increased the removal efficiency of AOX in activated sludge. The Pd/Fe particles had a much higher removal efficiency of AOX in the activated sludge than bare Fe particles. A slightly acidic condition with a Pd content of 0.05% and 10 g/L of Pd/Fe was beneficial to the process of removing AOX in activated sludge. In detail, the removal efficiency of AOX in the activated sludge could reach 50.7% after 15 days of reaction with 10 g/L of Pd/Fe (Pd loading 0.05 wt %) and at an initial pH of 6.0 during the experiments. -
The Effect of Individual and Mixtures of Mycotoxins and Persistent
Food and Chemical Toxicology 130 (2019) 68–78 Contents lists available at ScienceDirect Food and Chemical Toxicology journal homepage: www.elsevier.com/locate/foodchemtox The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation T using in vitro reporter gene assays ∗ Ukpai A. Ezea,b,1, John Huntrissc, Michael N. Routledged, Yun Yun Gonga,e, , Lisa Connollyf a School of Food Science and Nutrition, Food Science Building, University of Leeds, LS2 9JT, UK b Department of Medical Laboratory Sciences, Faculty of Health Sciences, Ebonyi State University, P. M. B. 053, Abakaliki, Nigeria c Division of Reproduction and Early Development, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, LS2 9JT, UK d Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, LS2 9JT, UK e Department of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Ministry of Health, Beijing, 100021, PR China f Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, Northern Ireland, BT9 5AF, UK ARTICLE INFO ABSTRACT Keywords: The mycotoxins zearalenone (ZEN) and alpha-zearalenone (α-ZOL), which are common contaminants of agri- Mycotoxins food products, are known for their oestrogenic potential. In addition to mycotoxins, food may also contain Chemical mixtures pesticides with oestrogenic properties such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (p,p'-DDT) and 1,1- Food-borne chemical contaminants dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), raising the question on the potential effects of individual Reporter gene assay and combinations of these xeno-oestrogens on the action of natural oestrogens. -
Safe Thermal Decomposition of Organochloride Pesticides by Submerged Oxidation in Molten Salts LAINETTI, P
Safe Thermal Decomposition of Organochloride Pesticides by Submerged Oxidation in Molten Salts LAINETTI, P. E. O. A a. Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP, São Paulo * Corresponding author: [email protected] Abstract This study was motivated by the current interest in the world in the development of advanced processes for waste decomposition, category in which the process described herein is inserted. This interest stems from the need for safer processes for the decomposition of some wastes, particularly those deemed hazardous or present significant impact on the environment. The technology developed fits into this principle and it is applicable for intrinsically safe disposal of hazardous organic wastes, particularly the organochloride, whose degradation has presented problems when using the most common methods, such as incineration. Pesticides banned, obsolete or discarded constitute a serious environmental risk around the world, especially in developing countries. The HCHS, or Hexachlorcyclohexanes also called BHC or Lindane, are organochloride insecticides that have been banned in most countries in the 70s and 80s. It is one of the compounds that constitute the group of so-called POPs, or persistent organic pollutants that are regulated internationally by the Basel Convention. Among the major POPs could be cited pesticides, dioxins and PCBs that represent, according to the United Nations Industrial Development Organization - UNIDO, one of the most serious and urgent problems to be faced, because on the one hand, -
Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas Matthew E
Journal of the Arkansas Academy of Science Volume 72 Article 19 2018 Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas Matthew E. Grilliot Auburn University--Montgomery, [email protected] John L. Hunt University of Arkansas at Monticello, [email protected] Christopher G. Sims University of Arkansas at Monticello, [email protected] Follow this and additional works at: https://scholarworks.uark.edu/jaas Part of the Environmental Health Commons, and the Zoology Commons Recommended Citation Grilliot, Matthew E.; Hunt, John L.; and Sims, Christopher G. (2018) "Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas," Journal of the Arkansas Academy of Science: Vol. 72 , Article 19. Available at: https://scholarworks.uark.edu/jaas/vol72/iss1/19 This article is available for use under the Creative Commons license: Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0). Users are able to read, download, copy, print, distribute, search, link to the full texts of these articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This Article is brought to you for free and open access by ScholarWorks@UARK. It has been accepted for inclusion in Journal of the Arkansas Academy of Science by an authorized editor of ScholarWorks@UARK. For more information, please contact [email protected], [email protected]. Journal of the Arkansas Academy of Science, Vol. 72 [], Art. 19 Organochloride Pesticides Present in Animal Fur, Soil, and Streambed in an Agricultural Region of Southeastern Arkansas M.E. -
Prohibited Chemicals
PROHIBITED CHEMICALS CHEMICAL TRADE NAME NOTES Atrazine Atrazine Toxicity group III Gesaprim Atraflo Bladex Terbutal Parathion Folidol An organophosphate. Extremely toxic, Toxic group I. Banned in 17 Diethyl (p –nitropheny) phosphothioate Parafos countries, restricted use status in RSA. Agrithion PCP Woodprufe An organochloride Pentachlorophenol Timerlife Pentachlorophenyl Borcide Timbertret Anti-stain Chlordane Termidan An organochlorine insecticide. Moderately, toxic, toxic group I Octahoro-a hexahydror-methiodene Chlorsdasol Banned in 25 countries, restricted status in RSA Aldicard Termik A N-Methyl Carbonate insecticide. Extremely toxic, Toxic group I Methyl-(methylthio)-propinaldehyne Methylcarbonmoy oxine EDB Edabrom A halocarbon pesticide. Toxic group II. Dibromoethane Gerbex Banned in 14 countries. Restricted status in RSA. Aquamix Bacfume Dieldrin Aldrin An organochlorine insecticide. Highly toxic, Toxic group I. Hexachloro-hexahydro-dimethanonaphthalene HHDN Banned in 34 countries. Restricted status in RSA. Plus derivities Aldrin and Endrin Shelldrite DDT Dichloro-diphenyl trichloro-ethane plus derivities DDE and DDD Difethialone Rattex Brodifacoum Finale Difenacoum Tornadel Flocoumafen Tornadel Chlorofluoro-carbon Total phase-out by 1996. Manreal protocol 1987, amended CFC-11 , CFC-12 , CFC-113 , CFC-114 , CFC- Copenhagen 1992. 115 Halon gas Total phase-out by 1996. Manreal protocol 1987, amended Halon -1211 , Halon1301 , Halon -2402 Copenhagen 1992. Carbon – tetrachloride CC14 Total phase-out by 1996. Manreal protocol 1987, -
Tetrachloroethylene Facts
TETRACHLOROETHYLENE CAS # 127-18-4 Agency for Toxic Substances and Disease Registry ToxFAQs September 1997 This fact sheet answers the most frequently asked health questions (FAQs) about tetrachloroethylene. For more information, call the ATSDR Information Center at 1-888-422-8737. This fact sheet is one in a series of summaries about hazardous substances and their health effects. It’s important you understand this information because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. HIGHLIGHTS: Tetrachloroethylene is a manufactured chemical used for dry cleaning and metal degreasing. Exposure to very high concentrations of tetrachloroethylene can cause dizziness, headaches, sleepiness, confusion, nausea, difficulty in speaking and walking, unconsciousness, and death. Tetrachloroethylene has been found in at least 771 of the 1,430 National Priorities List sites identified by the Environmental Protection Agency (EPA). What is tetrachloroethylene? How might I be exposed to tetrachloroethylene? (Pronounced tµt”r…-klôr“ ½-µth“…-l¶n”) q When you bring clothes from the dry cleaners, they will release small amounts of tetrachloroethylene into the air. Tetrachloroethylene is a manufactured chemical that is q widely used for dry cleaning of fabrics and for metal-degreas- When you drink water containing tetrachloroethylene, you are exposed to it. ing. It is also used to make other chemicals and is used in some consumer products. Other names for tetrachloroethylene include perchloroet- How can tetrachloroethylene affect my health? hylene, PCE, and tetrachloroethene. It is a nonflammable High concentrations of tetrachloroethylene (particularly liquid at room temperature. -
Pentachlorophenol Report Response to PSB Docket #8310 Filed April 26, 2016 Pentachlorophenol Workgroup Participants
Pentachlorophenol Report Response to PSB Docket #8310 Filed April 26, 2016 Pentachlorophenol Workgroup Participants Chuck Schwer: Group Facilitator, Agency of Natural Resources (ANR) Ashley Desmond: Agency of Natural Resources (ANR), Sites Michael B. Smith Management Section Sarah Vose: Department of Health (VDH) Bill Jordan: Public Service Department (PSD) Cary Giguere: Agency of Agriculture Food and Markets (AAFM) Jeff Comstock Linda Boccuzzo Deb Gaynor: Town of Monkton Wendy Sue Harper Kim Greenwood: Vermont Natural Resources Council (VNRC) Tim Upton: Green Mountain Power (GMP) Tim Follensbee: Vermont Electric Power Company (VELCO) Scott Allocca: Fairpoint Communications Jeff Austin Dan Weston: Washington Electric Cooperative (WEC) Scott Martino Jeff Miller: Treated Wood Council (TWC) Roger Donegan: International Brotherhood of Electrical Workers (IBEW) Jeffrey Wimette Local 300 ii Acronyms AAFM Agency of Agriculture, Food & Markets (Vermont) ACZA Ammoniacal copper zinc arsenate ANR Agency of Natural Resources (Vermont) ATSDR Agency for Toxic Substances and Disease Registry (federal) AWPA American Wood Protection Association BMP Best Management Practices BTEX Benzene, toluene, ethylbenzene, xylenes CCA Chromated copper arsenate CFR Code of Federal Register CIS Consumer Information Sheet CuNap Copper napthenate FIFRA Federal Insecticide, Fungicide and Rodenticide Act g/L grams per liter GHS Global Harmonization System GIDMO Gravitational induced Downward Migration of Oil HCB hexachlorobenzene HHE Health hazard evaluation IBEW International