Drug Adherence Assessment Report

APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Drug Adherence Assessment Report Prescribed Medications: CYMBALTA, FIORICET, HYDROCODONE/APAP, NEURONTIN, NORTRIPTYLINE, SOMA, TRAMADOL, VENLAFAXINE, XANAX, CODEINE, PROMETHAZINE, STADOL, ACETAMINOPHEN, ABILIFY, CHLORPROMAZINE, TIAGABINE, TOPAMAX, BRINTELLIX, TRILEPTAL, GLUMETZA (Metformin), PALIPERIDONE, DARVON, CARBAMAZEPINE, TEGRETOL, GEODON, PLAVIX (CLOPIDOGREL), PREVACID (LANSOPRAZOLE), PANTOPRAZOLE, WARFARIN, SIMVASTATIN, OMEPRAZOLE, SUDAFED (Pseudoephedrine), INVEGA SUSTENNA, ZYLOPRIM (Allopurinol)

CONSISTENT RESULTS - REPORTED MEDICATION DETECTED (PARENT DRUG AND/OR METABOLITE) REPORTED ANTICIPATED TEST DETECTION WINDOW PRESCRIPTION POSITIVE(S) OUTCOME

ABILIFY Aripiprazole POSITIVE Plasma Half-Life: 75-94 hours ACETAMINOPHEN Acetaminophen POSITIVE Plasma Half-Life: 2-3 hours BRINTELLIX Vortioxetine POSITIVE Plasma Half-Life: 66 hours CHLORPROMAZINE Chlorpromazine POSITIVE Plasma Half-Life: 30 hours CODEINE Codeine POSITIVE Plasma Half-Life: 2-4 hours CODEINE Morphine POSITIVE Plasma Half-Life: 1.3-7 hours CODEINE Dihydrocodeine POSITIVE Plasma Half-Life: 4 hours CODEINE NorCodeine POSITIVE Plasma Half-Life: 2-4 hours CYMBALTA Duloxetine POSITIVE Plasma Half-Life: 8-17 hours FIORICET Acetaminophen POSITIVE Plasma Half-Life: 2-3 hours FIORICET Caffeine POSITIVE Plasma Half-Life: 5-6 hours GLUMETZA (Metformin) Metformin POSITIVE Plasma Half-Life: 6-7 hours HYDROCODONE/APAP Hydrocodone POSITIVE Plasma Half-Life: 3.5-9 hours HYDROCODONE/APAP Norhydrocodone POSITIVE Plasma Half-Life: 3.5-9 hours HYDROCODONE/APAP Hydromorphone POSITIVE Plasma Half-Life: 1.5-4 hours NEURONTIN Gabapentin POSITIVE Plasma Half-Life: 5-7 hours NORTRIPTYLINE Nortriptyline POSITIVE Plasma Half-Life: 26 hours PALIPERIDONE 9-Hydroxyrisperidone POSITIVE Plasma Half-Life: 5-6 days PROMETHAZINE Promethazine POSITIVE Plasma Half-Life: 16-19 hours SOMA Carisoprodol POSITIVE Plasma Half-Life: 2 hours SOMA Meprobamate POSITIVE Plasma Half-Life: 10 hours STADOL Butorphanol POSITIVE Plasma Half-Life: 18 hours TIAGABINE Tiagabine POSITIVE Plasma Half-Life: 2-5 hours TOPAMAX Topiramate POSITIVE Plasma Half-Life: 19-25 hours TRAMADOL Tramadol POSITIVE Plasma Half-Life: 4-8 hours TRAMADOL N-Desmethyl-Tramadol POSITIVE Plasma Half-Life: 4-10 hours TRAMADOL O-Desmethyl-Tramadol POSITIVE Plasma Half-Life: 4-10 hours TRILEPTAL Carbamazepine POSITIVE Plasma Half-Life: 18-65 hours TRILEPTAL Oxcarbazepine POSITIVE Plasma Half-Life: 1-5 hours

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 1 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

TRILEPTAL 10-11-Dihydro-10-Hydroxycarbamazepine POSITIVE Plasma Half-Life: 8-10 hours VENLAFAXINE Venlafaxine POSITIVE Plasma Half-Life: 3-7 hours VENLAFAXINE O-Desmethyl-Venlafaxine POSITIVE Plasma Half-Life: 9-13 hours XANAX Alprazolam POSITIVE Plasma Half-Life: 6-27 hours XANAX Alpha-hydroxyalprazolam POSITIVE Plasma Half-Life: 13-20 hours DARVON Propoxyphene POSITIVE Plasma Half-Life: 8-24 hours DARVON Norpropoxyphene POSITIVE Plasma Half-Life: 16-30 hours CARBAMAZEPINE Carbamazepine POSITIVE Plasma Half-Life: 18-65 hours CARBAMAZEPINE 10-11-Dihydro-10-Hydroxycarbamazepine POSITIVE Plasma Half-Life: 8-10 hours GEODON Ziprasidone POSITIVE Plasma Half-Life: 7-10 hours INVEGA SUSTENNA 9-Hydroxyrisperidone POSITIVE Plasma Half-Life: 5-6 days OMEPRAZOLE Omeprazole POSITIVE Plasma Half-Life: less than 1 hour PANTOPRAZOLE Pantoprazole POSITIVE Plasma Half-Life: 1 hour PLAVIX (CLOPIDOGREL) Clopidogrel POSITIVE Plasma Half-Life: 7-8 hours SIMVASTATIN Simvastatin POSITIVE Plasma Half-Life: SUDAFED (Pseudoephedrine) Pseudoephedrine POSITIVE Plasma Half-Life: 4-8 hours TEGRETOL Carbamazepine POSITIVE Plasma Half-Life: 18-65 hours TEGRETOL 10-11-Dihydro-10-Hydroxycarbamazepine POSITIVE Plasma Half-Life: 8-10 hours WARFARIN Warfarin POSITIVE Plasma Half-Life: 20-60 hours ZYLOPRIM (Allopurinol) Oxipurinol POSITIVE Plasma Half-Life: 1-2 hours

INCONSISTENT RESULTS - REPORTED MEDICATION NOT DETECTED (NEITHER PARENT DRUG NOR METABOLITE) REPORTED ANTICIPATED TEST DETECTION WINDOW PRESCRIPTION POSITIVE(S) OUTCOME

N/A N/A N/A N/A

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 2 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

INCONSISTENT RESULTS - ANALYTE DETECTED BUT NO CORRESPONDING PRESCRIPTION REPORTED DETECTED ILLICIT MEASURED CUTOFF TEST DETECTION WINDOW ANALYTE RESULT OUTCOME

Buprenorphine No 200 <10 POSITIVE Plasma Half-Life: 26-42 hours Norbuprenorphine No 200 <10 POSITIVE Plasma Half-Life: 15-150 hours Fentanyl No 200 <5 POSITIVE Plasma Half-Life: 3-12 hours Norfentanyl No 200 <5 POSITIVE Plasma Half-Life: 9-10 hours Levorphanol No 200 <5 POSITIVE Plasma Half-Life: 11-30 hours Meperidine No 200 <5 POSITIVE Plasma Half-Life: 3-4 hours Methadone No 200 <5 POSITIVE Plasma Half-Life: 15-55 hours EDDP No 200 <5 POSITIVE Plasma Half-Life: 15-55 hours Oxycodone No 200 <5 POSITIVE Plasma Half-Life: 3-6 hours Noroxycodone No 200 <10 POSITIVE Plasma Half-Life: 3-6 hours Oxymorphone No 200 <10 POSITIVE Plasma Half-Life: 7.5-9.5 hours Tapentadol No 200 <10 POSITIVE Plasma Half-Life: 4 hours Clonazepam No 200 <5 POSITIVE Plasma Half-Life:19-60 hours 7-Aminoclonazepam No 200 <5 POSITIVE Plasma Half-Life: 30-92 hours Diazepam No 200 <5 POSITIVE Plasma Half-Life: 21-37 hours Nordiazepam No 200 <5 POSITIVE Plasma Half-Life: 36-200 hours Temazepam No 200 <5 POSITIVE Plasma Half-Life: 3-13 hours Oxazepam No 200 <5 POSITIVE Plasma Half-Life: 4-11 hours Lorazepam No 200 <125 POSITIVE Plasma Half-Life: 9-16 hours Alpha-Hydroxytriazolam No 200 <5 POSITIVE Plasma Half-Life: 3-4 hrs 6-Hydroxybuspirone No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Buspirone No 200 <10 POSITIVE Plasma Half-Life: 2-3 hours Triazolam No 200 <5 POSITIVE Plasma Half-Life: 1-6 hours Prazepam No 200 <10 POSITIVE Plasma Half-Life: 29-224 hours Norchlordiazepoxide No 200 <10 POSITIVE Plasma Half-Life: 6-28 hours N-Desmethyl-Flunitrazepam No 200 <5 POSITIVE Plasma Half-Life: 16-35 hours Flunitrazepam No 200 <5 POSITIVE Plasma Half-Life: 16-35 hours Estazolam No 200 <5 POSITIVE Plasma Half-Life: 1-6 hours Clobazam No 200 <5 POSITIVE Plasma Half-Life:18 hours Chlordiazepoxide No 200 <5 POSITIVE Plasma Half-Life: 6-28 hours Clozapine No 200 <5 POSITIVE Plasma Half-Life: 14 hours Clozapine_N_oxide No 200 <10 POSITIVE Plasma Half-Life: 14 hours Fluphenazine No 200 <5 POSITIVE Plasma Half-Life: 14-15 hours Quetiapine No 200 <5 POSITIVE Plasma Half-Life: 6-7 hours Thioridazine No 200 <10 POSITIVE Plasma Half-Life: 5-26 hours Thiothixene No 200 <10 POSITIVE Plasma Half-Life: 4-24 hours Risperidone No 200 <5 POSITIVE Plasma Half-Life: 3 hours Olanzapine No 200 <10 POSITIVE Plasma Half-Life: 21-54 hours Asenapine No 200 <50 POSITIVE Plasma Half-Life: 24 hours Norquetiapine No 200 <50 POSITIVE Plasma Half-Life: 7-12 hours

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 3 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Lurasidone No 200 <10 POSITIVE Plasma Half-Life:14-18 hours Iloperidone No 200 <10 POSITIVE Plasma Half-Life: 18-33 hours Dehydro Aripiprazole No 200 <125 POSITIVE Plasma Half-Life: 75-94 hours Haloperidol No 200 <5 POSITIVE Plasma Half-Life: 14-37 hours Amitriptyline No 200 <5 POSITIVE Plasma Half-Life: 10-28 hours Bupropion No 200 <5 POSITIVE Plasma Half-Life: 12-30 hours Citalopram No 200 <10 POSITIVE Plasma Half-Life: 35 hours Doxepin No 200 <5 POSITIVE Plasma-Half-Life: 8-25 hours Fluoxetine No 200 <5 POSITIVE Plasma Half-Life: 4 days Mirtazapine No 200 <5 POSITIVE Plasma Half-Life: 20-40 hours Paroxetine No 200 <10 POSITIVE Plasma Half-Life: 21 hours Sertraline No 200 <5 POSITIVE Plasma Half-Life: 23-26 hours Trazodone No 200 <5 POSITIVE Plasma Half-Life: 10-12 hours Clomipramine No 200 <5 POSITIVE Plasma Half-Life: 19-37 hours Vilazodone No 200 <125 POSITIVE Plasma Half-Life: 25 hours Yangonin No 200 <10 POSITIVE Plasma Half-Life: 9 hours Amoxapine No 200 <10 POSITIVE Plasma Half-Life: 8 hours Normirtazapine No 200 <1 POSITIVE Plasma Half-Life: 20-40 hours Norfluoxetine No 200 <10 POSITIVE Plasma Half-Life: 4-16 days Nordoxepin No 200 <5 POSITIVE Plasma Half-Life: 31 hours Milnacipran No 200 <1 POSITIVE Plasma Half-Life: 8 hours Hydroxybupropion No 200 <10 POSITIVE Plasma Half-Life: 12-30 hours D-L-Kavain No 200 <10 POSITIVE Plasma Half-Life: 9 hours Desmethoxyyangonin No 200 <50 POSITIVE Plasma Half-Life: 9 hours Dihydromethysticin No 200 <5 POSITIVE Plasma Half-Life: 9 hours Dihydrokavain No 200 <50 POSITIVE Plasma Half-Life: 9 hours Methysticin No 200 <5 POSITIVE Plasma Half-Life: 9 hours N-Desmethyl-Clomipramine No 200 <5 POSITIVE Plasma Half-Life: 19-37 hours Imipramine No 200 <5 POSITIVE Plasma Half-Life: 10-16 hours Fluvoxamine No 200 <5 POSITIVE Plasma Half-Life: 26 hours Desipramine No 200 <5 POSITIVE Plasma Half-Life: 12-30 hours Zolpidem No 200 <5 POSITIVE Plasma Half-Life: 2-3 hours Zopiclone-N-Oxide No 200 <125 POSITIVE Plasma Half-Life: 3.5-5 hours Alpha-Hydroxymidazolam No 200 <5 POSITIVE Plasma Half-Life: 1-3 hours Zaleplon No 200 <10 POSITIVE Plasma Half-Life: 1 hour Midazolam No 200 <5 POSITIVE Plasma Half-Life: 1-3 hours Flurazepam No 200 <5 POSITIVE Plasma Half-Life: 2-3 hours Desalkylflurazepam No 200 <5 POSITIVE Plasma Half-Life: 74-90 hours Lamotrigine No 200 <10 POSITIVE Plasma Half-Life: 22-38 hours Levetiracetam No 200 <5 POSITIVE Plasma Half-Life: 6-8 hours Pregabalin No 200 <10 POSITIVE Plasma Half-Life: 6-6.3 hours Zonisamide No 200 <125 POSITIVE Plasma Half-Life: 63 hours Licarbazepine No 550 <500 POSITIVE Plasma Half-Life: 9-13 hours Primidone No 200 <10 POSITIVE Plasma Half-Life: 3-12 hours

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 4 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Phenytoin No 200 <10 POSITIVE Valproic Acid No 200 <10 POSITIVE Plasma Half-Life: 10-16 hours Cyclobenzaprine No 200 <5 POSITIVE Plasma Half-Life: 8-37 hours Baclofen No 200 <10 POSITIVE Plasma Half-Life: 3-4 hrs Methocarbamol No 200 <50 POSITIVE Plasma Half-Life: 1-2 hours Amphetamine No 200 <5 POSITIVE Plasma Half-Life: 7-34 hours Methylphenidate No 200 <5 POSITIVE Plasma Half-Life: 1.5-4.5 hours Ritalinic Acid No 200 <5 POSITIVE Plasma Half-Life: 1.8-2.5 hours Ephedrine No 200 <10 POSITIVE Plasma Half-Life: 3-6 hours Atomoxetine No 200 <10 POSITIVE Plasma Half-Life: 5-6 hours Lisdexamfetamine No 200 <5 POSITIVE Plasma Half-Life: <1 hour Dextromethorphan No 200 <5 POSITIVE Plasma Half-Life: 2-4 hours Marinol No 200 <50 POSITIVE Plasma Half-Life: 25-36 hours Phentermine No 200 <10 POSITIVE Plasma Half-Life: 16-31 hours Naloxone No 200 <5 POSITIVE Plasma Half-Life: 30-80 minutes Naltrexone No 200 <5 POSITIVE Plasma Half-Life: 4-13 hours MDA Yes 200 <125 POSITIVE Plasma Half-Life: 11-17 hours MDEA Yes 200 <5 POSITIVE Plasma Half-Life: 6-11 hours MDMA Yes 200 <50 POSITIVE Plasma Half-Life: 6-10 hours Mephedrone Yes 200 <5 POSITIVE Plasma Half-Life: 30-90 minutes Cocaine Yes 200 <5 POSITIVE Plasma Half-Life: 0.7-1.5 hours Benzoylecgonine Yes 200 <5 POSITIVE Plasma Half-Life: 5.5-7.5 hours THC (Marijuana metabolite) Yes 200 <50 POSITIVE Plasma Half-Life: 4-12 hours AM2201 (Spice Cannabinoid) Yes 200 <50 POSITIVE Plasma Half-Life: 2-8 hours HU-210 (Spice Cannabinoid) Yes 200 <50 POSITIVE Plasma Half-Life: 2-8 hours JWH-019 (Spice Cannabinoid) Yes 200 <50 POSITIVE Plasma Half-Life: 2-8 hours JWH-073 4-Hydroxybutyl (Spice Cannabinoid)Yes 200 <10 POSITIVE Plasma Half-Life: 2-8 hours JWH-081 (Spice Cannabinoid) Yes 200 <10 POSITIVE Plasma Half-Life: 2-8 hours JWH-122 (Spice Cannabinoid) Yes 200 <5 POSITIVE Plasma Half-Life: 2-8 hours JWH-18-5-pentanoic acid (Spice Cannabinoid)Yes 200 <5 POSITIVE Plasma Half-Life: 2-8 hours JWH-18-5-pentanyl (Spice Cannabinoid) Yes 200 <5 POSITIVE Plasma Half-Life: 2-8 hours JWH-250-5OH-pentanyl (Spice Cannabinoid)Yes 200 <10 POSITIVE Plasma Half-Life: 2-8 hours Methamphetamine Yes 200 <5 POSITIVE Plasma Half-Life: 6-17 hours 6-MAM (heroin metabolite) Yes 200 <10 POSITIVE Plasma Half-Life: 6-15 minutes PCP Yes 200 <5 POSITIVE Plasma Half-Life: 7-46 hours 7-HydroxyMitragynine (Kratom) No 200 <5 POSITIVE Plasma Half-Life: 5-7 hours MMB-CHMICA Yes 200 <5 POSITIVE Plasma Half-Life: <1 hour FDU-PB-22 Yes 200 <10 POSITIVE Plasma Half-Life: 12.5 min N-Desmethyl-U-47700 Yes 200 <5 POSITIVE 100-400 ng/mL (acute overdose) Didesmethyl-U-47700 Yes 200 <5 POSITIVE 100-400 ng/mL (acute overdose) Carfentanil Yes 200 <10 POSITIVE Plasma Half-Life: 7-8 hours Acetyl-Fentanyl Yes 200 <5 POSITIVE 90–945 ng/mL (acute overdose) AB-FUBINACA Yes 200 <5 POSITIVE Plasma Half-Life: <1 hour 5-Fluoro-NPB-22 Yes 200 <50 POSITIVE Plasma Half-Life: 15 min

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 5 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

5-MeO-DMT Yes 200 <5 POSITIVE Plasma Half-Life: 15 min Mitragynine (Kratom) No 200 <5 POSITIVE Plasma Half-Life: 7-39 hours Methylone Yes 200 <5 POSITIVE Plasma Half-Life: 1 hour MDPV Yes 200 <5 POSITIVE Plasma Half-Life: 77-98 hours DMT Yes 200 <5 POSITIVE Plasma Half-Life: 15 min Amobarbital No 200 <5 POSITIVE Plasma Half-Life: 8-42 hours Secobarbital No 200 <5 POSITIVE Plasma Half-Life: 15-40 hours Pentobarbital No 200 <5 POSITIVE Plasma Half-Life: 15-48 hours Phenobarbital No 200 <5 POSITIVE Plasma Half-Life: 53-118 hours Butalbital No 200 <50 POSITIVE Plasma Half-Life: 35 hours Butabarbital No 200 <50 POSITIVE Plasma Half-Life: 100 hours (-)-Cotinine No 200 <5 POSITIVE Plasma Half-Life:10-27 hours Ethyl Sulfate (Ethanol) No 200 <5 POSITIVE Plasma Half-Life: 3-4 hours Ethyl Glucuronide (Ethanol) No 200 <5 POSITIVE Plasma Half-Life: 3-4 hours Desloratadine No 200 <10 POSITIVE Plasma Half-Life: 27 hours Tofacitinib No 200 <10 POSITIVE Plasma Half-Life: 6 hours Sumatriptan No 200 <10 POSITIVE Plasma Half-Life: 2-3 hours Piroxicam No 200 <10 POSITIVE Plasma Half-Life: 50 hours Colchicine No 200 <10 POSITIVE Plasma Half-Life: 26-31 hours Chlorpheniramine No 200 <10 POSITIVE Plasma Half-Life: 13-43 hours Cetirizine No 200 <10 POSITIVE Plasma Half-Life: 6-8 hours Celecoxib No 200 <10 POSITIVE Plasma Half-Life: 8-12 hours Olopatadine No 200 <10 POSITIVE Plasma Half-Life: 3 hours Naproxen No 200 <10 POSITIVE Plasma Half-Life: 15 hours Montelukast No 200 <10 POSITIVE Plasma Half-Life: 2-6 hours Meloxicam No 200 <10 POSITIVE Plasma Half-Life: 20 hours Loratadine No 200 <10 POSITIVE Plasma Half-Life: 8 hours Indomethacin No 200 <10 POSITIVE Plasma Half-Life: 5-10 hours Ibuprofen No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Hydroxyzine No 200 <10 POSITIVE Plasma Half-Life: 20 hours Hydroxychloroquine No 200 <10 POSITIVE Plasma Half-Life: 32-52 days Fexofenadine No 200 <10 POSITIVE Plasma Half-Life: 14-15 hours Febuxostat No 200 <10 POSITIVE Plasma Half-Life: 5-8 hours Etodolac No 200 <10 POSITIVE Plasma Half-Life: 6-7 hours Diphenhydramine No 200 <10 POSITIVE Plasma Half-Life: 8-10 hours Diclofenac No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Diltiazem No 200 <10 POSITIVE Plasma Half-Life: 3-5 hours Verapamil No 200 <10 POSITIVE Plasma Half-Life: 5-12 hours Valsartan No 200 <10 POSITIVE Plasma Half-Life: 6 hours Ticagrelor No 200 <10 POSITIVE Plasma Half-Life: 7 hours Terazosin No 200 <10 POSITIVE Plasma Half-Life: 12 hours Telmisartan No 200 <10 POSITIVE Plasma Half-Life: 24 hours Rivaroxaban No 200 <10 POSITIVE Plasma Half-Life: 5-9 hours Ranolazine No 200 <10 POSITIVE Plasma Half-Life: 7 hours

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 6 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Propranolol No 200 <10 POSITIVE Plasma Half-Life: 4-5 hours Dabigatran No 200 <10 POSITIVE Plasma Half-Life: 7-9 hours Cilostazol No 200 <10 POSITIVE Plasma Half-Life: 11-13 hours Carvedilol No 200 <10 POSITIVE Plasma Half-Life: 7-10 hours Candesartan No 200 <10 POSITIVE Plasma Half-Life: 9-10 hours Candesartan Cilexetil No 200 <10 POSITIVE Plasma Half-Life: Bisoprolol No 200 <10 POSITIVE Plasma Half-Life: 9-12 hours Benazeprilat No 200 <10 POSITIVE Plasma Half-Life: 10-11 hours Atorvastatin No 200 <10 POSITIVE Plasma Half-Life: 14 hours Atenolol No 200 <10 POSITIVE Plasma Half-Life: 6-7 hours Apixaban No 200 <10 POSITIVE Plasma Half-Life: 12 hours Amlodipine No 200 <10 POSITIVE Plasma Half-Life: 30-50 hours Amiodarone No 200 <10 POSITIVE Plasma Half-Life: 58 days Acebutolol No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Pentoxifylline No 200 <10 POSITIVE Plasma Half-Life: less than 1 hour Olmesartan Acid No 200 <10 POSITIVE Plasma Half-Life: Nifedipine No 200 <10 POSITIVE Plasma Half-Life: 2 hours Nadolol No 200 <10 POSITIVE Plasma Half-Life: 14-24 hours Metoprolol No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Losartan No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Lisinopril No 200 <10 POSITIVE Plasma Half-Life: 12 hours Labetalol No 200 <10 POSITIVE Plasma Half-Life: 6-8 hours Irbesartan No 200 <10 POSITIVE Plasma Half-Life: 11-15 hours Hydrochlorothiazide No 200 <10 POSITIVE Plasma Half-Life: 6-15 hours Glimepiride No 200 <10 POSITIVE Plasma Half-Life:5-8 hours Gemfibrozil No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Flecainide No 200 <10 POSITIVE Plasma Half-Life: 12-17 hours Fenofibric Acid No 200 <10 POSITIVE Plasma Half-Life: 20 hours Ezetimibe No 200 <10 POSITIVE Plasma Half-Life: 22 hours Enalaprilat No 200 <10 POSITIVE Plasma Half-Life: 11 hours Eletriptan No 200 <10 POSITIVE Plasma Half-Life: 4 hours Dronedarone No 200 <10 POSITIVE Plasma Half-Life: 13-19 hours Doxazosin No 200 <10 POSITIVE Plasma Half-Life: 22 hours Dipyridamole No 200 <10 POSITIVE Plasma Half-Life: 10 hours Darifenacin No 200 <10 POSITIVE Plasma Half-Life: 13-19 hours Nitrofurantoin No 200 <10 POSITIVE Plasma Half-Life: 20-60 min Itraconazole No 200 <10 POSITIVE Plasma Half-Life: 21 hours Famotidine No 200 <10 POSITIVE Plasma Half-Life: 1-3 hours Ranitidine No 200 <10 POSITIVE Plasma Half-Life: 2-3 hours Biotin No 200 <10 POSITIVE Plasma Half-Life: 1 hour Ondansetron No 200 <10 POSITIVE Plasma Half-Life: 2-5 hours Metoclopramide No 200 <10 POSITIVE Plasma Half-Life: 5-6 hours Lansoprazole No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Hyoscyamine No 200 <10 POSITIVE Plasma Half-Life: 3-5 hours

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 7 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Glipizide No 200 <10 POSITIVE Plasma Half-Life: 2-7 hours Sitagliptin No 200 <10 POSITIVE Plasma Half-Life: 8-14 hours Saxagliptin No 200 <10 POSITIVE Plasma Half-Life: 2-3 hours Rosiglitazone No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Repaglinide No 200 <10 POSITIVE Plasma Half-Life: 1 hours Pioglitazone No 200 <10 POSITIVE Plasma Half-Life: 40 hours Nateglinide No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Linagliptin No 200 <10 POSITIVE Plasma Half-Life: 24 hours Glyburide No 200 <10 POSITIVE Plasma Half-Life: 10 hours Furosemide No 200 <10 POSITIVE Plasma Half-Life: 4-10 hours Triamterene No 200 <10 POSITIVE Plasma Half-Life:1-2 hours Torsemide No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Solifenacin No 200 <10 POSITIVE Plasma Half-Life: 45-65 hours Chlorothiazide No 200 <10 POSITIVE Plasma Half-Life: 1-3 hours Canrenone No 200 <10 POSITIVE Plasma Half-Life: 4-22 hours Alfuzosin No 200 <10 POSITIVE Plasma Half-Life: 10 hours Acetazolamide No 200 <10 POSITIVE Plasma Half-Life: 6-9 hours Indapamide No 200 <10 POSITIVE Plasma Half-Life: 14-18 hours Sildenafil No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Vardenafil No 200 <10 POSITIVE Plasma Half-Life: 4 hours Tadalafil No 200 <10 POSITIVE Plasma Half-Life: 17-18 hours Dexamethasone No 200 <10 POSITIVE Plasma Half-Life: 36-54 hours Raloxifene No 200 <10 POSITIVE Plasma Half-Life: 27-28 hours Prednisolone No 200 <10 POSITIVE Plasma Half-Life: 3-4 hours Levothyroxine No 200 <10 POSITIVE Plasma Half-Life: 6-7 Days Budesonide No 200 <10 POSITIVE Plasma Half-Life: 2-3 hours Finasteride No 200 <10 POSITIVE Plasma Half-Life: 5-6 hours Methotrexate No 200 <10 POSITIVE Plasma Half-Life: 18-15 hours Ondansetron No 200 <10 POSITIVE Plasma Half-Life: 2-5 hours Donepezil No 200 <10 POSITIVE Plasma Half-Life: 70 hours Rivastigmine No 200 <10 POSITIVE Plasma Half-Life: 1-2 hours Ropinirole No 200 <10 POSITIVE Plasma Half-Life: 5-6 hours

SPECIMEN VALIDITY TESTING TEST TEST MEASURED REFERENCE ADDITIONAL MEDICATIONS REPORTED OUTCOME RESULT RANGE BUT NOT TESTED FOR IN THIS REPORT

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 8 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

1.NARCOTIC ANALGESICS-OPIODS/OPIATES Run by: CT on 4/24/2018 1:07 PM Acetaminophen Positive 200 <50 ng/mL No Consistent Result Buprenorphine Positive 200 <10 ng/mL No Inconsistent Result Norbuprenorphine Positive 200 <10 ng/mL No Inconsistent Result Codeine Positive 200 <10 ng/mL No Consistent Result Fentanyl Positive 200 <5 ng/mL No Inconsistent Result Norfentanyl Positive 200 <5 ng/mL No Inconsistent Result Hydrocodone Positive 200 <5 ng/mL No Consistent Result Norhydrocodone Positive 200 <5 ng/mL No Consistent Result Hydromorphone Positive 200 <10 ng/mL No Consistent Result Morphine Positive 200 <10 ng/mL No Consistent Result Levorphanol Positive 200 <5 ng/mL No Inconsistent Result Meperidine Positive 200 <5 ng/mL No Inconsistent Result Methadone Positive 200 <5 ng/mL No Inconsistent Result EDDP Positive 200 <5 ng/mL No Inconsistent Result Oxycodone Positive 200 <5 ng/mL No Inconsistent Result Noroxycodone Positive 200 <10 ng/mL No Inconsistent Result Oxymorphone Positive 200 <10 ng/mL No Inconsistent Result Propoxyphene Positive 200 <10 ng/mL No Consistent Result Norpropoxyphene Positive 200 <10 ng/mL No Consistent Result Tapentadol Positive 200 <10 ng/mL No Inconsistent Result Tramadol Positive 200 <5 ng/mL No Consistent Result N-Desmethyl-Tramadol Positive 200 <5 ng/mL No Consistent Result O-Desmethyl-Tramadol Positive 200 <5 ng/mL No Consistent Result Butorphanol Positive 200 <5 ng/mL No Consistent Result NorCodeine Positive 200 <5 ng/mL No Consistent Result Dihydrocodeine Positive 200 <10 ng/mL No Consistent Result 2.BENZODIAZEPINES Run by: CT on 4/24/2018 1:07 PM Alprazolam Positive 200 <10 ng/mL No Consistent Result Alpha-hydroxyalprazola Positive 200 <5 ng/mL No Consistent Result m Clonazepam Positive 200 <5 ng/mL No Inconsistent Result 7-Aminoclonazepam Positive 200 <5 ng/mL No Inconsistent Result Diazepam Positive 200 <5 ng/mL No Inconsistent Result Nordiazepam Positive 200 <5 ng/mL No Inconsistent Result Temazepam Positive 200 <5 ng/mL No Inconsistent Result Oxazepam Positive 200 <5 ng/mL No Inconsistent Result Lorazepam Positive 200 <125 ng/mL No Inconsistent Result Alpha-Hydroxytriazola Positive 200 <5 ng/mL No Inconsistent Result m 6-Hydroxybuspirone Positive 200 <10 ng/mL No Inconsistent Result Buspirone Positive 200 <10 ng/mL No Inconsistent Result Triazolam Positive 200 <5 ng/mL No Inconsistent Result Prazepam Positive 200 <10 ng/mL No Inconsistent Result Norchlordiazepoxide Positive 200 <10 ng/mL No Inconsistent Result N-Desmethyl-Flunitraz Positive 200 <5 ng/mL No Inconsistent Result

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 9 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

2.BENZODIAZEPINES Run by: CT on 4/24/2018 1:07 PM epam Flunitrazepam Positive 200 <5 ng/mL No Inconsistent Result Estazolam Positive 200 <5 ng/mL No Inconsistent Result Clobazam Positive 200 <5 ng/mL No Inconsistent Result Chlordiazepoxide Positive 200 <5 ng/mL No Inconsistent Result 3.ANTIPSYCHOTICS Run by: CT on 4/24/2018 1:07 PM Aripiprazole Positive 200 <125 ng/mL No Consistent Result Chlorpromazine Positive 255 <250 ng/mL No Consistent Result Clozapine Positive 200 <5 ng/mL No Inconsistent Result Clozapine_N_oxide Positive 200 <10 ng/mL No Inconsistent Result Fluphenazine Positive 200 <5 ng/mL No Inconsistent Result Quetiapine Positive 200 <5 ng/mL No Inconsistent Result Thioridazine Positive 200 <10 ng/mL No Inconsistent Result Ziprasidone Positive 200 <10 ng/mL No Consistent Result 9-Hydroxyrisperidone Positive 200 <5 ng/mL No Consistent Result Thiothixene Positive 200 <10 ng/mL No Inconsistent Result Risperidone Positive 200 <5 ng/mL No Inconsistent Result Olanzapine Positive 200 <10 ng/mL No Inconsistent Result Asenapine Positive 200 <50 ng/mL No Inconsistent Result Norquetiapine Positive 200 <50 ng/mL No Inconsistent Result Lurasidone Positive 200 <10 ng/mL No Inconsistent Result Iloperidone Positive 200 <10 ng/mL No Inconsistent Result Dehydro Aripiprazole Positive 200 <125 ng/mL No Inconsistent Result Haloperidol Positive 200 <5 ng/mL No Inconsistent Result 4.ANTIDEPRESSANTS Run by: CT on 4/24/2018 1:07 PM Amitriptyline Positive 200 <5 ng/mL No Inconsistent Result Bupropion Positive 200 <5 ng/mL No Inconsistent Result Citalopram Positive 200 <10 ng/mL No Inconsistent Result Doxepin Positive 200 <5 ng/mL No Inconsistent Result Duloxetine Positive 200 <5 ng/mL No Consistent Result Fluoxetine Positive 200 <5 ng/mL No Inconsistent Result Mirtazapine Positive 200 <5 ng/mL No Inconsistent Result Paroxetine Positive 200 <10 ng/mL No Inconsistent Result Sertraline Positive 200 <5 ng/mL No Inconsistent Result Trazodone Positive 200 <5 ng/mL No Inconsistent Result Venlafaxine Positive 200 <10 ng/mL No Consistent Result O-Desmethyl-Venlafaxi Positive 200 <5 ng/mL No Consistent Result ne Clomipramine Positive 200 <5 ng/mL No Inconsistent Result Vortioxetine Positive 200 <1 ng/mL No Consistent Result Vilazodone Positive 200 <125 ng/mL No Inconsistent Result Yangonin Positive 200 <10 ng/mL No Inconsistent Result Amoxapine Positive 200 <10 ng/mL No Inconsistent Result Normirtazapine Positive 200 <1 ng/mL No Inconsistent Result Norfluoxetine Positive 200 <10 ng/mL No Inconsistent Result

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 10 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

4.ANTIDEPRESSANTS Run by: CT on 4/24/2018 1:07 PM Nordoxepin Positive 200 <5 ng/mL No Inconsistent Result Milnacipran Positive 200 <1 ng/mL No Inconsistent Result Hydroxybupropion Positive 200 <10 ng/mL No Inconsistent Result D-L-Kavain Positive 200 <10 ng/mL No Inconsistent Result Desmethoxyyangonin Positive 200 <50 ng/mL No Inconsistent Result Dihydromethysticin Positive 200 <5 ng/mL No Inconsistent Result Dihydrokavain Positive 200 <50 ng/mL No Inconsistent Result Methysticin Positive 200 <5 ng/mL No Inconsistent Result Nortriptyline Positive 200 <5 ng/mL No Consistent Result N-Desmethyl-Clomipra Positive 200 <5 ng/mL No Inconsistent Result mine Imipramine Positive 200 <5 ng/mL No Inconsistent Result Fluvoxamine Positive 200 <5 ng/mL No Inconsistent Result Desipramine Positive 200 <5 ng/mL No Inconsistent Result 5.DEPRESSANTS Run by: CT on 4/24/2018 1:07 PM Zolpidem Positive 200 <5 ng/mL No Inconsistent Result Zopiclone-N-Oxide Positive 200 <125 ng/mL No Inconsistent Result Alpha-Hydroxymidazol Positive 200 <5 ng/mL No Inconsistent Result am Zaleplon Positive 200 <10 ng/mL No Inconsistent Result Midazolam Positive 200 <5 ng/mL No Inconsistent Result Flurazepam Positive 200 <5 ng/mL No Inconsistent Result Desalkylflurazepam Positive 200 <5 ng/mL No Inconsistent Result 6.ANTICONVULSANTS Run by: CT on 4/24/2018 1:07 PM Carbamazepine Positive 200 <10 ng/mL No Consistent Result Gabapentin Positive 200 <5 ng/mL No Consistent Result Lamotrigine Positive 200 <10 ng/mL No Inconsistent Result Levetiracetam Positive 200 <5 ng/mL No Inconsistent Result Oxcarbazepine Positive 200 <10 ng/mL No Consistent Result 10-11-Dihydro-10-Hydr Positive 200 <5 ng/mL No Consistent Result oxycarbamazepine Pregabalin Positive 200 <10 ng/mL No Inconsistent Result Tiagabine Positive 200 <10 ng/mL No Consistent Result Zonisamide Positive 200 <125 ng/mL No Inconsistent Result Licarbazepine Positive 550 <500 ng/mL No Inconsistent Result Topiramate Positive 200 <1 ng/mL No Consistent Result Primidone Positive 200 <10 ng/mL No Inconsistent Result Phenytoin Positive 200 <10 ng/mL No Inconsistent Result Valproic Acid Positive 200 <10 ng/mL No Inconsistent Result 7.MUSCLE RELAXANTS Run by: CT on 4/24/2018 1:07 PM Carisoprodol Positive 200 <50 ng/mL No Consistent Result Meprobamate Positive 200 <10 ng/mL No Consistent Result Cyclobenzaprine Positive 200 <5 ng/mL No Inconsistent Result Baclofen Positive 200 <10 ng/mL No Inconsistent Result Methocarbamol Positive 200 <50 ng/mL No Inconsistent Result

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 11 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

8.STIMULANT Run by: CT on 4/24/2018 1:07 PM Amphetamine Positive 200 <5 ng/mL No Inconsistent Result Caffeine Positive 200 <125 ng/mL No Consistent Result Methylphenidate Positive 200 <5 ng/mL No Inconsistent Result Ritalinic Acid Positive 200 <5 ng/mL No Inconsistent Result Ephedrine Positive 200 <10 ng/mL No Inconsistent Result Atomoxetine Positive 200 <10 ng/mL No Inconsistent Result Lisdexamfetamine Positive 200 <5 ng/mL No Inconsistent Result 9.DECONGESTANTS Run by: CT on 4/24/2018 1:07 PM Dextromethorphan Positive 200 <5 ng/mL No Inconsistent Result Pseudoephedrine Positive 200 <10 ng/mL No Consistent Result 10.APPETITE STIMULANTS Run by: CT on 4/24/2018 1:07 PM Marinol Positive 200 <50 ng/mL No Inconsistent Result Phentermine Positive 200 <10 ng/mL No Inconsistent Result 11.ANTIDOTES Run by: CT on 4/24/2018 1:07 PM Naloxone Positive 200 <5 ng/mL No Inconsistent Result Naltrexone Positive 200 <5 ng/mL No Inconsistent Result 12.ILLICITS Run by: CT on 4/24/2018 1:07 PM MDA Positive 200 <125 ng/mL Yes Inconsistent Result MDEA Positive 200 <5 ng/mL Yes Inconsistent Result MDMA Positive 200 <50 ng/mL Yes Inconsistent Result Mephedrone Positive 200 <5 ng/mL Yes Inconsistent Result Cocaine Positive 200 <5 ng/mL Yes Inconsistent Result Benzoylecgonine Positive 200 <5 ng/mL Yes Inconsistent Result THC (Marijuana Positive 200 <50 ng/mL Yes Inconsistent Result metabolite) AM2201 (Spice Positive 200 <50 ng/mL Yes Inconsistent Result Cannabinoid) HU-210 (Spice Positive 200 <50 ng/mL Yes Inconsistent Result Cannabinoid) JWH-019 (Spice Positive 200 <50 ng/mL Yes Inconsistent Result Cannabinoid) JWH-073 Positive 200 <10 ng/mL Yes Inconsistent Result 4-Hydroxybutyl (Spice Cannabinoid) JWH-081 (Spice Positive 200 <10 ng/mL Yes Inconsistent Result Cannabinoid) JWH-122 (Spice Positive 200 <5 ng/mL Yes Inconsistent Result Cannabinoid) JWH-18-5-pentanoic Positive 200 <5 ng/mL Yes Inconsistent Result acid (Spice Cannabinoid) JWH-18-5-pentanyl Positive 200 <5 ng/mL Yes Inconsistent Result (Spice Cannabinoid) JWH-250-5OH-pentany Positive 200 <10 ng/mL Yes Inconsistent Result l (Spice Cannabinoid) Methamphetamine Positive 200 <5 ng/mL Yes Inconsistent Result 6-MAM (heroin Positive 200 <10 ng/mL Yes Inconsistent Result metabolite) Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 12 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

12.ILLICITS Run by: CT on 4/24/2018 1:07 PM PCP Positive 200 <5 ng/mL Yes Inconsistent Result 7-HydroxyMitragynine Positive 200 <5 ng/mL No Inconsistent Result (Kratom) MMB-CHMICA Positive 200 <5 ng/mL Yes Inconsistent Result FDU-PB-22 Positive 200 <10 ng/mL Yes Inconsistent Result N-Desmethyl-U-47700 Positive 200 <5 ng/mL Yes Inconsistent Result Didesmethyl-U-47700 Positive 200 <5 ng/mL Yes Inconsistent Result Carfentanil Positive 200 <10 ng/mL Yes Inconsistent Result Acetyl-Fentanyl Positive 200 <5 ng/mL Yes Inconsistent Result AB-FUBINACA Positive 200 <5 ng/mL Yes Inconsistent Result 5-Fluoro-NPB-22 Positive 200 <50 ng/mL Yes Inconsistent Result 5-MeO-DMT Positive 200 <5 ng/mL Yes Inconsistent Result Mitragynine (Kratom) Positive 200 <5 ng/mL No Inconsistent Result Methylone Positive 200 <5 ng/mL Yes Inconsistent Result MDPV Positive 200 <5 ng/mL Yes Inconsistent Result DMT Positive 200 <5 ng/mL Yes Inconsistent Result 13.BARBITURATES Run by: CT on 4/24/2018 1:07 PM Amobarbital Positive 200 <5 ng/mL No Inconsistent Result Secobarbital Positive 200 <5 ng/mL No Inconsistent Result Pentobarbital Positive 200 <5 ng/mL No Inconsistent Result Phenobarbital Positive 200 <5 ng/mL No Inconsistent Result Butalbital Positive 200 <50 ng/mL No Inconsistent Result Butabarbital Positive 200 <50 ng/mL No Inconsistent Result 14.DIRECT BIOMARKERS Run by: CT on 4/24/2018 1:07 PM (-)-Cotinine Positive 200 <5 ng/mL No Inconsistent Result Ethyl Sulfate (Ethanol) Positive 200 <5 ng/mL No Inconsistent Result Ethyl Glucuronide Positive 200 <5 ng/mL No Inconsistent Result (Ethanol) 15. ANTI-INFLAMMATORY / NSAIDs Run by: CT on 4/24/2018 1:07 PM Desloratadine Positive 200 <10 ng/mL No Inconsistent Result Tofacitinib Positive 200 <10 ng/mL No Inconsistent Result Sumatriptan Positive 200 <10 ng/mL No Inconsistent Result Promethazine Positive 200 <10 ng/mL No Consistent Result Piroxicam Positive 200 <10 ng/mL No Inconsistent Result Colchicine Positive 200 <10 ng/mL No Inconsistent Result Chlorpheniramine Positive 200 <10 ng/mL No Inconsistent Result Cetirizine Positive 200 <10 ng/mL No Inconsistent Result Celecoxib Positive 200 <10 ng/mL No Inconsistent Result Oxipurinol Positive 200 <10 ng/mL No Consistent Result Olopatadine Positive 200 <10 ng/mL No Inconsistent Result Naproxen Positive 200 <10 ng/mL No Inconsistent Result Montelukast Positive 200 <10 ng/mL No Inconsistent Result Meloxicam Positive 200 <10 ng/mL No Inconsistent Result Loratadine Positive 200 <10 ng/mL No Inconsistent Result Indomethacin Positive 200 <10 ng/mL No Inconsistent Result

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 13 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

15. ANTI-INFLAMMATORY / NSAIDs Run by: CT on 4/24/2018 1:07 PM Ibuprofen Positive 200 <10 ng/mL No Inconsistent Result Hydroxyzine Positive 200 <10 ng/mL No Inconsistent Result Hydroxychloroquine Positive 200 <10 ng/mL No Inconsistent Result Fexofenadine Positive 200 <10 ng/mL No Inconsistent Result Febuxostat Positive 200 <10 ng/mL No Inconsistent Result Etodolac Positive 200 <10 ng/mL No Inconsistent Result Diphenhydramine Positive 200 <10 ng/mL No Inconsistent Result Diclofenac Positive 200 <10 ng/mL No Inconsistent Result 16. CARDIOVASCULAR Run by: CT on 4/24/2018 1:07 PM Diltiazem Positive 200 <10 ng/mL No Inconsistent Result Warfarin Positive 200 <10 ng/mL No Consistent Result Verapamil Positive 200 <10 ng/mL No Inconsistent Result Valsartan Positive 200 <10 ng/mL No Inconsistent Result Ticagrelor Positive 200 <10 ng/mL No Inconsistent Result Terazosin Positive 200 <10 ng/mL No Inconsistent Result Telmisartan Positive 200 <10 ng/mL No Inconsistent Result Rivaroxaban Positive 200 <10 ng/mL No Inconsistent Result Ranolazine Positive 200 <10 ng/mL No Inconsistent Result Propranolol Positive 200 <10 ng/mL No Inconsistent Result Simvastatin Positive 200 <10 ng/mL No Consistent Result Dabigatran Positive 200 <10 ng/mL No Inconsistent Result Clopidogrel Positive 200 <10 ng/mL No Consistent Result Cilostazol Positive 200 <10 ng/mL No Inconsistent Result Carvedilol Positive 200 <10 ng/mL No Inconsistent Result Candesartan Positive 200 <10 ng/mL No Inconsistent Result Candesartan Cilexetil Positive 200 <10 ng/mL No Inconsistent Result Bisoprolol Positive 200 <10 ng/mL No Inconsistent Result Benazeprilat Positive 200 <10 ng/mL No Inconsistent Result Atorvastatin Positive 200 <10 ng/mL No Inconsistent Result Atenolol Positive 200 <10 ng/mL No Inconsistent Result Apixaban Positive 200 <10 ng/mL No Inconsistent Result Amlodipine Positive 200 <10 ng/mL No Inconsistent Result Amiodarone Positive 200 <10 ng/mL No Inconsistent Result Acebutolol Positive 200 <10 ng/mL No Inconsistent Result Pentoxifylline Positive 200 <10 ng/mL No Inconsistent Result Olmesartan Acid Positive 200 <10 ng/mL No Inconsistent Result Nifedipine Positive 200 <10 ng/mL No Inconsistent Result Nadolol Positive 200 <10 ng/mL No Inconsistent Result Metoprolol Positive 200 <10 ng/mL No Inconsistent Result Losartan Positive 200 <10 ng/mL No Inconsistent Result Lisinopril Positive 200 <10 ng/mL No Inconsistent Result Labetalol Positive 200 <10 ng/mL No Inconsistent Result Irbesartan Positive 200 <10 ng/mL No Inconsistent Result Hydrochlorothiazide Positive 200 <10 ng/mL No Inconsistent Result Glimepiride Positive 200 <10 ng/mL No Inconsistent Result Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 14 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

16. CARDIOVASCULAR Run by: CT on 4/24/2018 1:07 PM Gemfibrozil Positive 200 <10 ng/mL No Inconsistent Result Flecainide Positive 200 <10 ng/mL No Inconsistent Result Fenofibric Acid Positive 200 <10 ng/mL No Inconsistent Result Ezetimibe Positive 200 <10 ng/mL No Inconsistent Result Enalaprilat Positive 200 <10 ng/mL No Inconsistent Result Eletriptan Positive 200 <10 ng/mL No Inconsistent Result Dronedarone Positive 200 <10 ng/mL No Inconsistent Result Doxazosin Positive 200 <10 ng/mL No Inconsistent Result Dipyridamole Positive 200 <10 ng/mL No Inconsistent Result 17. ANTIBIOTICS / UTIs Run by: CT on 4/24/2018 1:07 PM Darifenacin Positive 200 <10 ng/mL No Inconsistent Result Nitrofurantoin Positive 200 <10 ng/mL No Inconsistent Result Itraconazole Positive 200 <10 ng/mL No Inconsistent Result 18. GASTROINTESTINAL / DIETARY Run by: CT on 4/24/2018 1:07 PM Famotidine Positive 200 <10 ng/mL No Inconsistent Result Ranitidine Positive 200 <10 ng/mL No Inconsistent Result Pantoprazole Positive 200 <10 ng/mL No Consistent Result Biotin Positive 200 <10 ng/mL No Inconsistent Result Ondansetron Positive 200 <10 ng/mL No Inconsistent Result Omeprazole Positive 200 <10 ng/mL No Consistent Result Metoclopramide Positive 200 <10 ng/mL No Inconsistent Result Lansoprazole Positive 200 <10 ng/mL No Inconsistent Result Hyoscyamine Positive 200 <10 ng/mL No Inconsistent Result 19. DIABETIC Run by: CT on 4/24/2018 1:07 PM Glipizide Positive 200 <10 ng/mL No Inconsistent Result Sitagliptin Positive 200 <10 ng/mL No Inconsistent Result Saxagliptin Positive 200 <10 ng/mL No Inconsistent Result Rosiglitazone Positive 200 <10 ng/mL No Inconsistent Result Repaglinide Positive 200 <10 ng/mL No Inconsistent Result Pioglitazone Positive 200 <10 ng/mL No Inconsistent Result Nateglinide Positive 200 <10 ng/mL No Inconsistent Result Metformin Positive 200 <10 ng/mL No Consistent Result Linagliptin Positive 200 <10 ng/mL No Inconsistent Result Glyburide Positive 200 <10 ng/mL No Inconsistent Result 20. DIURETICS / INCONTINENCE Run by: CT on 4/24/2018 1:07 PM Furosemide Positive 200 <10 ng/mL No Inconsistent Result Triamterene Positive 200 <10 ng/mL No Inconsistent Result Torsemide Positive 200 <10 ng/mL No Inconsistent Result Solifenacin Positive 200 <10 ng/mL No Inconsistent Result Chlorothiazide Positive 200 <10 ng/mL No Inconsistent Result Canrenone Positive 200 <10 ng/mL No Inconsistent Result Alfuzosin Positive 200 <10 ng/mL No Inconsistent Result Acetazolamide Positive 200 <10 ng/mL No Inconsistent Result Indapamide Positive 200 <10 ng/mL No Inconsistent Result 21. PDE / Phosphodiesterase Inhibitors Run by: CT on 4/24/2018 1:07 PM

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 15 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Test Name Outcome Measured Result Cutoff Units Illicit? Status

21. PDE / Phosphodiesterase Inhibitors Run by: CT on 4/24/2018 1:07 PM Sildenafil Positive 200 <10 ng/mL No Inconsistent Result Vardenafil Positive 200 <10 ng/mL No Inconsistent Result Tadalafil Positive 200 <10 ng/mL No Inconsistent Result 22. CORTICOSTEROIDS / HORMONE THERAPY Run by: CT on 4/24/2018 1:07 PM Dexamethasone Positive 200 <10 ng/mL No Inconsistent Result Raloxifene Positive 200 <10 ng/mL No Inconsistent Result Prednisolone Positive 200 <10 ng/mL No Inconsistent Result Levothyroxine Positive 200 <10 ng/mL No Inconsistent Result Budesonide Positive 200 <10 ng/mL No Inconsistent Result Finasteride Positive 200 <10 ng/mL No Inconsistent Result 23. ANTI-NEOPLASTICS / CANCER THERAPY Run by: CT on 4/24/2018 1:07 PM Methotrexate Positive 200 <10 ng/mL No Inconsistent Result Ondansetron Positive 200 <10 ng/mL No Inconsistent Result 24. DEMENTIA (Parkinson's/Alzheimer's) Run by: CT on 4/24/2018 1:07 PM Donepezil Positive 200 <10 ng/mL No Inconsistent Result Rivastigmine Positive 200 <10 ng/mL No Inconsistent Result Ropinirole Positive 200 <10 ng/mL No Inconsistent Result Morphine is a commonly detected metabolite among patients taking codeine. An active molecule of Opana, Oxymorphone is a commonly detected metabolite among patients taking Oxycodone. Opana (Oxymorphone) will not metabolize to Noroxycodone or Oxycodone. Hydromorphone is a commonly detected metabolite among patients taking Hydrocodone and Morphine. Oxazepam is commonly detected metabolite among patients taking Diazepam, Nor-Diazepam or Temazepam. Temazepam and Nor-Diazepam are commonly detected metabolites among patients taking Diazepam. Alprazolam, Alpha-OH-Alprazolam, Clonazepam, and 7-amino-Clonazepam are not detected in patients taking Diazepam, Nor-diazepam, Lorazepam, Oxazepam, and Temazepam. Meprobamate is a commonly detected metabolite among patients taking Carisoprodol and its presence is consistent with the use of Carisoprodol. An active (drug) or metabolite may be listed as a Negative Outcome, however, if either the active or any metabolite(s) are present (Positive), then the result is listed as Consistent for that reported prescribed medication. Metabolites can remain longer in the body than the parent drug. Sometimes only the metabolite may be detected in the urine and not the parent drug.

In case of patients consuming HYDROCODONE-containing medications: Norhydrocodone is the major metabolite of Hydrocodone indicating presence of Hydrocodone in the urine. While Hydrocodone can also be metabolized to Hydromorphone, identification of just Hydromorphone by itself is not a confirmation of Hydrocodone being present, since recent studies suggest that urine specimens of patients taking Hydrocodone always show presence of Hydrocodone or Norhydrocodone in combination with Hydromorphone. FOR PATIENT RESULTS INDICATING JUST THE PRESENCE OF HYDROMORPHONE: THIS MAY BE DERIVED FROM MORPHINE-CONTAINING PRESCRIPTION DRUGS OR HYDROMORPHONE-ONLY PRESCRIPTIONS (FOR EXAMPLE, DILAUDID). Further reading: Valtier,S. and Bebarta,V.S. (2012) Excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following single dose administration of hydrocodone to healthy volunteers. J. Anal. Toxicol., 36, 507–14. and Barakat,N.H., Atayee,R.S., Best,B.M. and Ma,J.D. (2014) Observations of Urinary Hydrocodone and Metabolite Distributions in Pain Patients. J. Anal. Toxicol., 38, 129–134.)

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 16 of 17 STAT[S] Corrected [C] Added [A] APPROVAL REQUIRED

Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 4/5/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

Notes: Specimen collected by CleanAssure: Dried Blood Spot Mitra™ Microsampling. This procedure is to determine the presence and concentration of prescription/non-prescription drugs from dried blood spots collected using Mitra™ Microsampling devices by finger pricks.

This method and associated validation is intended for patient compliance testing only (i.e. determination of the presence or absence and concentrations of prescribed and illicit drugs in dried blood spots) and is not validated for therapeutic drug monitoring (TDM) of drug plasma levels. Detection ranges may be reduced (compound-specific) versus urine toxicology test results. Mitra™ Microsampling devices improve patient comfort and increase operational efficiencies.

Cocaine and Benzoylecgonine, the major metabolite of Cocaine, was observed.

6-MAM, the major metabolite of Heroin, was observed.

(*) Levorphanol was detected:

Patients testing positive for Levorphanol may be consuming cough medication instead: Dextromethorphan, found in Common brands of Cough Medications (e.g. Robitussin, Zicam, Delsym), is an antitussive that has been proposed to have potential utility in the treatment of various neurological disorders (Steinberg et al., 1996). Dextromethorphan is a weak noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. It is metabolized in vivo to dextrorphan, a more potent noncompetitive NMDA antagonist that is the dextrorotatory enantiomer of the opioid agonist levorphanol. Source: Pechnick, R. N., & Poland, R. E. (2004). Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. The Journal of Pharmacology and Experimental Therapeutics, 309(2), 515–22.

Reviewed By: Date:

Originally Reported On: 4/24/2018 1:03 PM Accession: 80139 Patient ID: 1-49505 Printed: 4/24/2018 7:20 PM Lab Results For: Sample report COMP Page 17 of 17 STAT[S] Corrected [C] Added [A] FINAL COPY

______Patient: COMP, Sample report Acc #: 80139 Patient #: 1-49505 Birth: 04/05/1963 Doctor: Doctor, Test Age: 55 years Collection Date: 4/17/2018 1:27 PM Gender: Male Received in Lab: 4/17/2018 1:27 PM CT

FINAL COPY