Curriculum Vitae
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34 Annual Minisymposium on Reproductive Biology
34th Annual Minisymposium on Reproductive Biology January 26th, 2015 Lurie Medical Research Center 303 E. Superior St, Northwestern University, Chicago, IL Sponsored by The Office of the President The Office of the Vice President for Research The Graduate School Table of Contents About the Center for Reproductive Science/Center Sponsored Awards ....................... 3 Minisymposium on Reproductive Biology Overview ................................................... 5 Neena B. Schwartz Lectureship in Reproductive Science ............................................. 7 Lectureship Recipient, Richard L. Stouffer, PhD .......................................................... 9 The Legacy of Dr. Constance Campbell ...................................................................... 11 Northwestern Alumni Speaker, David L. Keefe, MD .................................................. 13 Program for Minisymposium ....................................................................................... 15 ABSTRACTS: Oral Session .............................................................................................................. 17 Poster Sessions .......................................................................................................... 21 List of Presenters .......................................................................................................... 47 Acknowledgements ...................................................................................................... 49 Front cover photograph courtesy -
Harris' Neuroendocrine Revolution
G FINK Of portal vessels and 226:2 T13–T24 Thematic Review self-priming 60 YEARS OF NEUROENDOCRINOLOGY MEMOIR: Harris’ neuroendocrine revolution: of portal vessels and self-priming Correspondence George Fink should be addressed to G Fink Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, Email Genetics Lane, Parkville, Victoria 3010, Australia george.fink@florey.edu.au or georgefi[email protected] Abstract Geoffrey Harris, while still a medical student at Cambridge, was the first researcher (1937) to Key Words provide experimental proof for the then tentative view that the anterior pituitary gland was " neurohormones controlled by the CNS. The elegant studies carried out by Harris in the 1940s and early 1950s, " hypophysial portal alone and in collaboration with John Green and Dora Jacobsohn, established that this control vessel blood was mediated by a neurohumoral mechanism that involved the transport by hypophysial " gonadotrophin-releasing hormone (GnRH) portal vessel blood of chemical substances from the hypothalamus to the anterior pituitary " self-priming effect of GnRH gland. The neurohumoral control of anterior pituitary secretion was proved by the isolation " oestrogen-induced and characterisation of the ‘chemical substances’ (mainly neuropeptides) and the finding that ovulatory GnRH surge Journal of Endocrinology these substances were released into hypophysial portal blood in a manner consistent with " oestrogen-induced increase their physiological functions. The new discipline of neuroendocrinology – the way that the in pituitary responsiveness brain controls endocrine glands and vice versa – revolutionised the treatment of endocrine to GnRH disorders such as growth and pubertal abnormalities, infertility and hormone-dependent tumours, and it underpins our understanding of the sexual differentiation of the brain and key aspects of behaviour and mental disorder. -
Folliculogenesis and Fertilization in the Domestic Dog: Application to Biomedical Research, Medicine, and Conservation
FOLLICULOGENESIS AND FERTILIZATION IN THE DOMESTIC DOG: APPLICATION TO BIOMEDICAL RESEARCH, MEDICINE, AND CONSERVATION A Dissertation Presented to the Faculty of the Graduate School of Cornell University in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy By Jennifer Beth Nagashima August 2015 © Jennifer Beth Nagashima FOLLICULOGENESIS AND FERTILIZATION IN THE DOMESTIC DOG: APPLICATIONS TO BIOMEDICAL RESEARCH, MEDICINE, AND CONSERVATION Jennifer Beth Nagashima, Ph.D. Cornell University 2015 Understanding of reproductive biology in canids, including the domestic dog, is surprisingly limited. This includes the regulators of ovarian follicle development, and mechanisms of anestrus termination, fertilization and embryo development. In turn, this lack of understanding has limited our ability to develop assisted reproductive technologies (ART) for endangered canid conservation efforts. ART of interest include in vitro follicle culture for maternal genome rescue, estrus induction protocols, and in vitro fertilization (IVF). Here, we describe: 1) Studies evaluating the stage-specific requirements for follicle stimulating hormone (FSH), luteinizing hormone (LH), and activin on domestic dog follicle development in vitro. We demonstrate the beneficial effects of FSH and activin on growth, and activin on antrum expansion and oocyte health in short term culture. 2) Evaluation of serum collected during the anestrus to estrus transition revealing a significant increase in anti-Müllerian hormone (AMH) during proestrus, likely originating from increased numbers of antral follicles during this time. 3) The birth of the first live puppies from IVF embryos utilizing in vivo matured oocytes. Further, consistently high rates of embryo production are obtained using the described system, with no effect of progesterone supplementation to embryo culture media. -
Gore, Andrea C. (1)
Last Updated 10-12-20 C.V. - Gore, Andrea C. (1) CURRICULUM VITAE Andrea C. Gore, Ph.D. Professor and Vacek Chair of Pharmacology Address The University of Texas at Austin Division of Pharmacology and Toxicology 107 W. Dean Keeton, Stop C0875, Room BME 3.510B Austin, TX 78712, USA Office phone: (512) 471-3669 Office fax: (512) 471-5002 Lab phone: (512) 471-6311 Lab fax: (512) 471-3589 email: [email protected] Gore Lab: https://sites.utexas.edu/gore/ Google Scholar: http://scholar.google.com/citations?user=iCgJEF0AAAAJ&hl=en My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45448158/?sort=date &direction=ascending ORCID: 0000-0001-5549-6793 Education 1990 Ph.D., Neuroscience Training Program, December 1990 University of Wisconsin, Madison, WI Supervisor: Dr. Ei Terasawa Dissertation title: “The roles of norepinephrine and neuropeptide Y in the control of the onset of puberty in female rhesus monkeys” 1985 A.B., Biology (cum laude), June 1985 Princeton University, Princeton, NJ Undergraduate Thesis Supervisor: Dr. Robert D. Lisk Thesis title: “Male dominance status, female choice and mating success in golden hamsters” Professional Experience and Appointments 2014-present Professor and Vacek Chair of Pharmacology (tenured) Division of Pharmacology and Toxicology, College of Pharmacy; Institute for Neuroscience; Institute for Cellular and Molecular Biology The University of Texas at Austin, Austin, TX 2008-2014 Gustavus & Louise Pfeiffer Professor of Toxicology (tenured) Division of Pharmacology and Toxicology, College of Pharmacy; Institute for Neuroscience; Institute for Cellular and Molecular Biology The University of Texas at Austin, Austin, TX Professor, Behavioral Neurosciences (Dept. -
Innovation Engines at Northwestern Medicine Women's Health Research Institute
THE INSTITUTES AT NORTHWESTERN MEDICINE INNOVATION ENGINES AT NORTHWESTERN MEDICINE WOMEN’S HEALTH RESEARCH INSTITUTE THE INSTITUTES AT NORTHWESTERN MEDICINE WOMEN’S HEALTH RESEARCH INSTITUTE AT NORTHWESTERN MEDICINE As an Innovation Engine at Northwestern Medicine, the mission of the Women’s Health Research Institute is to create the world’s leading institute in women’s health research and care. As new technology is enabling scientific advancement and healthcare reform is extending care to more Americans, research on sex-based differences across all body systems must become the norm. When we look at research and care through a sex-inclusive lens, our research investments will accelerate discovery and improve the quality of care for men and women. Why and How opportunities for prevention, misdiagnoses, When it comes to health, women and men are inadequate treatment, morbidities, and even death. different in ways beyond anatomy. Sex differences The passage of the National Institutes of Health have been discovered in such diverse areas as (NIH) Revitalization Act of 1993 was a critical autoimmune diseases, obesity, sleep disorders, milestone that mandated the inclusion of women digestive diseases, cancers, depression, drug in clinical research to improve healthcare for all interactions, and musculoskeletal issues. In some people. Unfortunately, nearly two decades later, cases, such as cardiovascular disease, sex only 37% of clinical human studies include women. differences have been well documented. In other Also, only 10% of pre-clinical studies using rodents diseases, the differences have neither been indicate the sex of the animals used. As a society, properly described nor studied. This knowledge gap we have work yet to be done to ensure that sex is undermining patient care. -
WOMEN in REPRODUCTIVE SCIENCE: Lessons From
158 3 REPRODUCTIONFOCUS REVIEW WOMEN IN REPRODUCTIVE SCIENCE Lessons from bioengineering the ovarian follicle: a personal perspective Teresa K Woodruff Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA Correspondence should be addressed to T K Woodruff; Email: [email protected] This paper forms part of a focus section on Women in Reproductive Science. The guest editor for this section was Professor Marilyn Renfree, Ian Potter Chair of Zoology, School of BioSciences, The University of Melbourne, Victoria, Australia Abstract The ovarian follicle and its maturation captivated my imagination and inspired my scientific journey – what we know now about this remarkable structure is captured in this invited review. In the past decade, our knowledge of the ovarian follicle expanded dramatically as cross-disciplinary collaborations brought new perspectives to bear, ultimately leading to the development of extragonadal follicles as model systems with significant clinical implications. Follicle maturation in vitro in an ‘artificial’ ovary became possible by learning what the follicle is fundamentally and autonomously capable of – which turns out to be quite a lot. Progress in understanding and harnessing follicle biology has been aided by engineers and materials scientists who created hardware that enables tissue function for extended periods of time. The EVATAR system supports extracorporeal ovarian function in an engineered environment that mimics the endocrine environment of the reproductive tract. Finally, applying the tools of inorganic chemistry, we discovered that oocytes require zinc to mature over time – a truly new aspect of follicle biology with no antecedent other than the presence of zinc in sperm. Drawing on the tools and ideas from the fields of bioengineering, materials science and chemistry unlocked follicle biology in ways that we could not have known or even predicted. -
Physiologist Physiologist
Published by The American Physiological Society Integrating the Life Sciences from Molecule to Organism The PhysiologistPhysiologist Association of Chairs of INSIDE Departments of Physiology 2006 Survey Results Richard L. Moss and William S. Spielman University of Wisconsin and Michigan State University APS Launches Stopgap The Association of Chairs of in Table 1 for the first time is infor- Departments of Physiology annual mation on the average number of con- Fellowship survey was emailed to 184 physiology tact hours for faculty and on the type Program departments throughout the US, of medical physiology course being p. 92 Canada, and Puerto Rico. A total of taught. 71 surveys were returned, for a Student/trainee information is pro- response rate of 38.5%. This rate is vided by ethnicity for predoctoral and AAMC Survey almost identical to that of the 2005 postdoctoral categories, as well as Results survey (39%). Of the 71 surveys predoctoral trainee completions, p. 98 returned, there were 22 public and 49 stipends provided, and type of sup- private medical schools. port (Table 2). The data provides the reader with Institutional information is provid- Opening up Open general trends of faculty, overall ed in Table 3. Departmental budget Access: Weaving departmental budgets, and space information (Table 4) shows type of the “Author Pays” available for research. As a reminder, support, faculty salaries derived from beginning in 2004, ACDP decided not grants along with negotiated indirect Safety Net to include faculty salary information costs to the departments. Table 5 p. 106 in this report. Because of the limited ranks responding Institutions accord- response rate and variability in ing to their total dollars, research APS Testifies departments responding on a year- grant dollars, and departmental by-year basis and the completeness of space. -
A Universal Solution for Regenerative Medicine Revolutionary Nanomaterials Developed at Northwestern Could Make It Possible to Repair Any Part of the Body
Winter 2016–17 Volume 04, Number 01 A publication for the alumni and friends of Northwestern University Feinberg School of Medicine, Northwestern Memorial HealthCare and the McGaw Medical Center of Northwestern University P.12 A Universal Solution for Regenerative Medicine Revolutionary nanomaterials developed at Northwestern could make it possible to repair any part of the body P.15 P.21 P.24 P.27 A Year of Impact Mental Health- Bringing Ethics Celebrating care on Hand to the Bench 30 Years of and Bedside ALS Care ADDRESS ALL CORRESPONDENCE TO: Northwestern University Call or e-mail us at 312.503.4210 or Feinberg School of Medicine [email protected] Office of Communications ©2017 Northwestern University. 420 E. Superior Street Northwestern Medicine® is a federally Rubloff 12th floor registered trademark of Northwestern Chicago, IL 60611 Memorial HealthCare and is used by Northwestern University. MEDICAL STUDENTS MELISSA MONTOYA, PETER ZHAN AND OTHER MEMBERS OF FEINBERG’S A CAPELLA GROUP, DOCAPELLA, SING DURING THE 38TH ANNUAL PERFORMANCE OF IN VIVO. THE VARIETY SHOW ON DECEMBER 2 ALSO FEATURED SHORT FILMS, DANCE ROUTINES AND, OF COURSE, SKITS POKING FUN AT THE MEDICAL SCHOOL EXPERIENCE. “THERE’S NOTHING QUITE LIKE THE FEELING OF BRINGING HUNDREDS OF FAMILIAR FACES TO LAUGHTER,” SAID SECOND-YEAR MEDICAL STUDENT NOAH WEINGARTEN, THE SHOW’S DIRECTOR. READ MORE ABOUT IN VIVO ONLINE AT MAGAZINE.NM.ORG. Northwestern Medicine 02 Northwestern Medicine Leadership Message WINTER 2016–17 Magazine A Successful Year for the Health -
NEENA B. SCHWARTZ, Phd
The Endocrine Society Oral History Collection The Clark Sawin Library NEENA B. SCHWARTZ, PhD Interview conducted by Michael Chappelle June 15, 2008 Copyright © 2008 by The Endocrine Society ii All uses of this manuscript are covered by a legal agreement between The Trustees of The Endocrine Society and Neena B. Schwartz, dated June 15, 2008. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Clark Sawin Library. No part of the manuscript may be quoted for publication without the written permission of the Director of Clark Sawin Library. Requests for permission to quote for publication should be addressed to The Endocrine Society Office, The Clark Sawin Library, Chevy Chase, Maryland, 20815, and should include identification of the specific passages to be quoted, anticipated use of the passages, and identification of the user. It is recommended that this oral history be cited as follows: Neena B. Schwartz, an oral history conducted in 2008 by Michael Chappelle, The Endocrine Society, The Clark Sawin Library, Chevy Chase, Maryland, 2008. iii INTRODUCTION Neena B. Schwartz, William Deering Professor Emerita of Biological Sciences at Northwestern University, is a pioneer in reproductive endocrinology for more than fifty years. She has made important contributions toward understanding the hormones involved in communication between the brain, pituitary gland, and reproductive organs; her long- standing interests include the mechanisms by which this communication normally occurs and how system dysfunction leads to reproductive disorders and disease. Throughout her career, she has been one of the most important leaders in promoting the careers of female life scientists and in creating an environment within national societies and granting agencies that has enabled many female scientists to follow in her footsteps. -
Involved in Ovarian Granulosa Cell Proliferation Gene Expression
Gene Expression Profiling Reveals Cyp26b1 to Be an Activin Regulated Gene Involved in Ovarian Granulosa Cell Proliferation Jingjing L. Kipp, Ann Golebiowski, Guadalupe Rodriguez, Michael Demczuk, Signe M. Kilen and Kelly E. Mayo Endocrinology 2011 152:303-312 originally published online Nov 17, 2010; , doi: 10.1210/en.2010-0749 To subscribe to Endocrinology or any of the other journals published by The Endocrine Society please go to: http://endo.endojournals.org//subscriptions/ Copyright © The Endocrine Society. All rights reserved. Print ISSN: 0021-972X. Online REPRODUCTION-DEVELOPMENT Gene Expression Profiling Reveals Cyp26b1 to Be an Activin Regulated Gene Involved in Ovarian Granulosa Cell Proliferation Jingjing L. Kipp, Ann Golebiowski,* Guadalupe Rodriguez,* Michael Demczuk, Signe M. Kilen, and Kelly E. Mayo Department of Biological Sciences (J.L.K., A.G., G.R., M.D.), DePaul University, Chicago, Illinois 60614; and Departments of Molecular Biosciences (S.M.K., K.E.M.) and Neurobiology and Physiology (K.E.M.) and Center for Reproductive Science (S.M.K., K.E.M.), Northwestern University, Evanston, Illinois 60208 Activin, a member of the TGF- superfamily, is an important modulator of FSH synthesis and secretion and is involved in reproductive dysfunctions and cancers. It also regulates ovarian follicle development. To understand the mechanisms and pathways by which activin regulates follicle function, we performed a microarray study and identified 240 activin regulated genes in mouse granulosa cells. The gene most strongly inhibited by activin was Cyp26b1, which encodes a P450 cytochrome enzyme that degrades retinoic acid (RA). Cyp26b1 has been shown to play an impor- tant role in male germ cell meiosis, but its expression is largely lost in the ovary around embryonic d 12.5. -
NIH Director's Pioneer Award 2008 Reviewers
NIH Director’s Pioneer Award 2008 Reviewers Phase 1 James C. Anthony, Ph.D. James Collins, Ph.D. Michigan State University Boston University East Lansing, MI Boston, MA David Baker, Ph.D. William Crowley Jr., M.D. University of Washington Harvard Medical School Seattle, WA Boston, MA Jeffrey Balser, M.D., Ph.D. Roger Detels, M.D. Vanderbilt University Medical Center University of California, Los Angeles Nashville, TN Los Angeles, CA Ben A. Barres, M.D., Ph.D. Jennifer Doudna, Ph.D. Stanford University School of Medicine University of California, Berkeley Stanford, CA Berkeley, CA Jacqueline Barton, Ph.D. Judy Dubno, Ph.D. California Institute of Technology Medical University of South Carolina Pasadena, CA Charleston, SC Leslie Berg, Ph.D. Thomas Earnest, Ph.D. University of Massachusetts Medical Center Lawrence Berkeley National Laboratory Worchester, MA Berkeley, CA Joan Heller Brown, Ph.D. Mostafa El-Sayed, Ph.D. University of California, San Diego Georgia Institute of Technology La Jolla, CA Atlanta, GA Timothy Buchman, M.D., Ph.D. Jennifer Elisseeff, Ph.D. Washington University School of Medicine Johns Hopkins University St. Louis, MO Baltimore, MD Cynthia Burrows, Ph.D. William Fals-Stewart, Ph.D. University of Utah University of Rochester Salt Lake City, UT Rochester, NY Charles Cantor, Ph.D. Marie Filbin, Ph.D. Sequenom, Inc. City University of New York San Diego, CA New York, NY Arup Chakraborty, Ph.D. Claire M. Fraser-Liggett, Ph.D. Massachusetts Institute of Technology University of Maryland Cambridge, MA Baltimore, MD 1 Gary H. Gibbons, M.D. Harry Honig, Ph.D. Morehouse School of Medicine Columbia University Atlanta, GA New York, NY Lila Gierasch, Ph.D. -
Physiologist Physiologist
Published by The American Physiological Society Integrating the Life Sciences from Molecule to Organism The PhysiologistPhysiologist Arthur C. Guyton Educator of the Year Teacher Quality Matters!! Stephen E. DiCarlo INSIDE Wayne State University School of Medicine Standing on the An Unbalanced Shoulders of Discussion From the Giants The following will President’s Desk My graduate men- not be a balanced dis- tor, Dr. H. Lowell cussion of our train- p. 91 Stone and my post- ing/preparation for doctoral mentor, Dr. teaching or how we Vernon S. Bishop, train our graduate 2009 ISI Impact studied with Dr. students to become Factors for APS Arthur C. Guyton. In effective teachers; or fact, Drs. Stone and even its importance Journals Bishop studied in medical education; p. 97 together with Dr. I will exaggerate a Guyton from 1961 bit. A preacher does through 1964. I not begin a sermon ILAR Releases heard many wonder- on the evils of alcohol ful stories about Dr. by admitting the Guide Update Guyton when Lowell comforting effect of a Stephen E. DiCarlo p. 105 and Vernon got beer after a hard day together, especially if their good friend at the laboratory (17). So, only the Dr. Aubrey Taylor was around. I also case against our training and prepa- 163rd APS had the great fortune of meeting Dr. ration for teaching, as well as how we Guyton. Thus, I know of his enormous prepare our graduate students to Business Meeting accomplishments directly, as well as become effective teachers will be pre- p. 107 from three men who knew him person- sented; the defense will be left to its ally.