(12) United States Patent (10) Patent No.: US 8.445,023 B2 Guimberteau Et Al
USOO8445,023B2 (12) United States Patent (10) Patent No.: US 8.445,023 B2 Guimberteau et al. (45) Date of Patent: May 21, 2013 (54) ANTI-MISUSE MICROPARTICULATE ORAL 6.264,983 B1 7/2001 Upadhyay PHARMACEUTICAL FORM 6,309.668 B1 10/2001 Bastin et al. 6,444,246 B1 9/2002 Popplewell et al. (75) Inventors: Florence Guimberteau, Montussan 6,566,560 B2 5, 2003 Travis (FR); Frederic Dargelas, Pessac (FR) (Continued) (73) Assignee: Flamel Technologies (FR) FOREIGN PATENT DOCUMENTS EP O198769 10, 1986 (*) Notice: Subject to any disclaimer, the term of this EP O7O9087 5, 1996 patent is extended or adjusted under 35 (Continued) U.S.C. 154(b) by 335 days. OTHER PUBLICATIONS (21) Appl. No.: 12/638,739 In the U.S. Patent and Trademark Office, Office Action in re: U.S. (22) Filed: Dec. 15, 2009 Appl. No. 1 1/651.577, dated Dec. 26, 2008, 22 pages. (65) Prior Publication Data (Continued) US 2010/0092.553 A1 Apr. 15, 2010 Primary Examiner — Paul Dickinson Related U.S. Application Data (74) Attorney, Agent, or Firm — Patton Boggs LLP (62) Division of application No. 1 1/439,432, filed on May 24, 2006. (57) ABSTRACT (60) Provisional application No. 60/735,182, filed on Nov. 10, 2005. The present invention relates to solid microparticulate oral pharmaceutical forms whose composition and structure make (30) Foreign Application Priority Data it possible to avoid misuse of the pharmaceutical active prin ciple (AP) they contain. Nov. 10, 2005 (FR) ...................................... O5 53437 The object of the present invention is to prevent solid oral (51) Int.
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