elvitegravir- cobicistat- emtricitabine-tenofovir AF ® (Genvoya ) 150-150-200-10 mg - green, oval tablet

® What is Genvoya ? If you stop taking HIV medicine, the amount The Genvoya® tablet contains 4 different of HIV virus in your blood will increase. medicines: elvitegravir, emtricitabine, and If you have Hepatitis B, stopping Genvoya® ® tenofovir AF. Genvoya is used to lower can make Hepatitis B worsen. the amount of HIV virus in your body and make your immune system stronger. Do not stop any of your HIV medicines without talking to your doctor. Cobicistat is a “booster” used to increase other HIV medicines to the correct level in the body. What should I expect? How do I take it? Genvoya® is usually well tolerated. Side effects may include:  Take 1 tablet once daily, at the same time every day  diarrhea  headache ®  Always take Genvoya with food, to  nausea or vomiting  sleep problems make sure the medicine is absorbed  stomach pain  tiredness into your body  skin colour changes  Do NOT take antacids, calcium, iron or magnesium supplements within 2 hours Rare, serious side effects may include: of Genvoya®  Allergic reaction: Signs include rash, Store in a dry place at room temperature, and blisters on skin or mouth, swelling of the keep out of reach of children. face or throat, difficulty breathing, fever or flu-like symptoms

 Liver problems: Signs include yellow skin What if I forget to take it? or eyes, dark urine, pale stools, or pain on It is very important to take Genvoya® every right side below ribs day to make sure that it keeps working. If  Mood changes, feeling sad or depressed you miss a dose, there is a higher chance that  New or worse kidney problems: Signs the virus will change to a form that is harder include being unable to pass urine or to treat. This is called “resistance”. change in amount of urine, blood in urine, If you miss a dose, take it as soon as you weight gain remember. If it is almost time for your  Loss of bone strength next dose, do not take 2 doses at the same  A condition called lactic acidosis: Signs time. If you are not sure if you should include unusual muscle pain, stomach take your dose, call the pharmacist. pain with nausea and vomiting, or a fast heartbeat or fast breathing

Always tell your doctor or pharmacist if  Medicines like vardenafil (Levitra®), side effects are bothering you. sildenafil (Viagra®) and tadalafil (Cialis®) IMMEDIATELY contact your doctor if you  Some medicines to treat seizures such as have any serious side effects phenytoin (Dilantin®) It is important to have regular blood tests to  Some cholesterol medicines watch for side effects and make sure your  Some heart medicines such as HIV medicine is working to control the virus. amiodarone, propafenone, and others Talk to your doctor if you are pregnant or are  Some blood thinners such as rivaroxaban thinking about becoming pregnant, or if you (Xarelto®), warfarin plan to breastfeed.  Some migraine headache medicines  Some pain medicines such as fentanyl ® Can I take Genvoya with  Some antibiotics such as rifampin other medicines?  Some medicines to treat depression and anxiety Some medicines may interact with Genvoya®. Drug interactions can stop your treatment  Some birth control medicines from working or may cause unwanted side  St. John's Wort effects. This is not a complete list of medicines that Always tell your pharmacist and doctor if interact with Genvoya®. you are using any prescription or non- Always check with your pharmacist before prescription medicines, vitamins, starting any new medicines to make sure that supplements, natural medicines or they are safe for you. recreational drugs: Medicines that may interact with Genvoya® What if I have questions? include: If you have questions or problems with your  Antacids (Tums®, Maalox®, Diovol®) and medicine, call St. Paul’s Hospital Ambulatory medicines with, calcium, iron, or Pharmacy: magnesium may be used but must be taken at least 2 hours before or 2 hours 1-888-511-6222 after Genvoya ® (Monday to Friday daytime and urgent issues after hours)  Corticosteroid inhalers (‘puffers’) and

nasal sprays such as fluticasone (Flovent®, To book an appointment to see a St. Paul’s Flonase®, Advair®), triamcinolone Hospital pharmacist, call reception: (Nasacort®), and budesonide (Pulmicort®, Symbicort®) can usually NOT be used. 604-806-8060  Some anti-inflammatory pain medicines (Monday to Friday daytime) (“NSAIDS”) such as ibuprofen (Advil®) or naproxen (Aleve®) may increase the risk This pamphlet is for general

of kidney problems. Low dose, short- information purposes only. It does not provide individual medical or term use is usually possible. treatment advice and is not a  ‘Puffers’ for asthma with salmeterol substitute for medical or professional care. (Serevent®, Advair®)

Elvitegravir-cobicistat-emtricitabine-tenofovir AF (Genvoya) Version Nov 5, 2019