G C A T T A C G G C A T genes Review Ancient DNA Studies in Pre-Columbian Mesoamerica Xavier Roca-Rada 1,* , Yassine Souilmi 1,2,3 , João C. Teixeira 1,4 and Bastien Llamas 1,2,3,4,* 1 Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia;
[email protected] (Y.S.);
[email protected] (J.C.T.) 2 National Centre for Indigenous Genomics, Australian National University, Canberra, ACT 0200, Australia 3 Environment Institute, University of Adelaide, Adelaide, SA 5005, Australia 4 Centre of Excellence for Australian Biodiversity and Heritage (CABAH), School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia * Correspondence:
[email protected] (X.R.-R.);
[email protected] (B.L.); Tel.: +61-8-8313-0262 (X.R.-R. & B.L.) Received: 1 October 2020; Accepted: 10 November 2020; Published: 13 November 2020 Abstract: Mesoamerica is a historically and culturally defined geographic area comprising current central and south Mexico, Belize, Guatemala, El Salvador, and border regions of Honduras, western Nicaragua, and northwestern Costa Rica. The permanent settling of Mesoamerica was accompanied by the development of agriculture and pottery manufacturing (2500 BCE–150 CE), which led to the rise of several cultures connected by commerce and farming. Hence, Mesoamericans probably carried an invaluable genetic diversity partly lost during the Spanish conquest and the subsequent colonial period. Mesoamerican ancient DNA (aDNA) research has mainly focused on the study of mitochondrial DNA in the Basin of Mexico and the Yucatán Peninsula and its nearby territories, particularly during the Postclassic period (900–1519 CE).