DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2008/0014272 A1 Skolnick Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2008/0014272 A1 Skolnick Et Al US 2008.0014272A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2008/0014272 A1 Skolnick et al. (43) Pub. Date: Jan. 17, 2008 (54) COMPOSITIONS AND METHODS FOR Publication Classification TREATMENT OF CHRONIC PAIN CONDITIONS (51) Int. Cl. A6II 3 L/403 (2006.01) (76) Inventors: Phil Skolnick, Edgewater, NJ (US); A6II 3/19 (2006.01) Warren Stern, Plymouth, MA (US) A6II 3/44 (2006.01) A6IR 9/00 (2006.01) Correspondence Address: A6IP 9/00 (2006.01) Jeffrey J. King, Esq. A6IP 9/02 (2006.01) BLACKLOWE & GRAHAM PLLC (52) U.S. Cl. ......................... 424/484: 514/282: 514/415; Suite 4800 514/557 701 Fifth Avenue Seattle, WA 98104 (US) (57) ABSTRACT (21) Appl. No. 11/775,721 The present invention relates to methods, pharmaceutical compositions and kits for treating osteoarthritis associated (22) Filed: Jul. 10, 2007 pain, inflammation and improving function in a patient comprising a first therapeutic agent which comprises bici Related U.S. Application Data fadine or a pharmaceutically acceptable salt, enantiomer, Solvate, hydrate, polymorph or prodrug thereof and a second (60) Provisional application No. 60/830,412, filed on Jul. therapeutic agent which comprises a non-steroidal anti 11, 2006. inflammatory drug or derivative thereof. 1 hr post-treatment 2 hr post-treatment 1. 2 SO Boifadine Morphine Treatment, (mg/kg PO) Patent Application Publication Jan. 17, 2008 Sheet 1 of 4 US 2008/0014272 A1 F - : 1hr post-treatment as 2 hr post-treatment S. - O s w Sg 25 is t f Wehicle 5 SO Bici fadine Morphine Treatment, (mg/kg PO) Figure 1 Patent Application Publication Jan. 17, 2008 Sheet 2 of 4 US 2008/0014272 A1 25 20 ss 15 10 S Sm 5 < 0 2C 5 -10 Placebo BiCifadine |buprofen Bici fadine + buprofer Figure 2 Patent Application Publication Jan. 17, 2008 Sheet 3 of 4 US 2008/0014272 A1 15 O -150 Placebo BC fade |buprofen Biciifadine + buprofen Figure 3 Patent Application Publication Jan. 17, 2008 Sheet 4 of 4 US 2008/0014272 A1 60 5 O 4. O 30 Placebo BiCifadine |buprofen Bici fadine + Ibuprofen Figure 4 US 2008/0014272 A1 Jan. 17, 2008 COMPOSITIONS AND METHODS FOR point where quality of life, functional capabilities, produc TREATMENT OF CHRONIC PAIN CONDITIONS tivity and other functional/activity measures are profoundly affected. RELATED APPLICATIONS 0006 Generally, OA is treated pharmacologically. How 0001. This application claims all priority benefits of U.S. ever, currently approved pharmacological agents such as Provisional patent application No. 60/830,412, filed Jul. 11, acetaminophen or non-steroidal anti-inflammatory drugs 2006 which is incorporated herein by reference. (NSAIDs). Such as aspirin, ibuprofen, and cyclo-oxyge nase-2 (COX-2) inhibitors, only reduce pain by approxi TECHNICAL FIELD mately 30 percent. (Schnitzer T.J. Update of ACR guidelines for osteoarthritis: role of coxibs. J. Pain Symptom Manage. 0002 The present invention relates to compositions and 2002; 23:S24-30; Easton B. T. Evaluation and treatment of methods for treatment of chronic pain conditions, including the subject with osteoarthritis. J. Family. Practice. 2001: 50: osteoarthritis, rheumatoid arthritis, chronic low back pain, 791-797: Chard J, Dieppe P. Update: treatment of osteoar and other chronic pain conditions. More specifically, the thritis. Arthritis and Rheumatism. 2002: 47: 686-690.) Ste present invention relates to compositions and methods to roids may be used to treat swelling caused by OA, however, alleviate chronic pain and/or to reduce functional disabilities steroids are contraindicated for long term use due to side associated with chronic pain. effects Such as increased bone loss and increased suscepti bility to infection. Surgery such as joint replacement, arthro BACKGROUND OF THE INVENTION scopic lavage and debridement, repositioning of bones or 0003 Chronic pain conditions are diverse and wide fusing of bones may also be recommended. However, Sur spread in humans and other Subjects, often causing serious gery, particularly in older patients, has increased risks of impacts on quality of life and resulting in serious disabilities complications and long recovery periods. including functional and activity impairment. The high 0007. There is therefore an urgent need in the art for new prevalence and morbidity of chronic pain conditions result and alternative treatments for management of chronic pain, in high costs for human and veterinary health care to treat including osteoarthritis, and for alleviating disabilities, chronic pain. Exemplary chronic pain conditions for which including function/activity impairment, in patients with new drugs and therapies are urgently needed include chronic pain. osteoarthritis pain; rheumatoid arthritis pain; cancer pain; and various other chronic pain conditions of non-neuro SUMMARY OF EXEMPLARY EMBODIMENTS pathic origin, such as chronic low back pain, chronic lumbar OF THE INVENTION and cervical pain, chronic fibromyalgia pain, chronic pain 0008. The present invention provides methods and com from arteriovenuous malformation, arachnoiditis, chronic positions to treat and/or prevent chronic pain conditions in pain from root avulsion, chronic postthoracotomy pain, and mammalian Subjects. The compositions and methods of the chronic postmastectomy pain of non-neuropathic origin. invention effectively treat a wide variety of chronic pain 0004 Osteoarthritis (OA), sometimes called degenera conditions and symptoms, including, for example, osteoar tive joint disease, hypertrophic arthritis, degenerative arthri thritis (OA) pain; rheumatoid arthritis pain; cancer pain; and tis or osteoarthrosis is the most common form of arthritis various other chronic pain conditions of non-neuropathic currently afflicting more than 21 million Americans. It is the origin, including chronic low back pain, chronic lumbar and most common rheumatic disease affecting humans and it is cervical pain, chronic fibromyalgia pain, chronic pain from the second most common disease responsible for disability arteriovenuous malformation, arachnoiditis, chronic pain in the United States. (Peyron J. G. Altman R D: The from root avulsion, chronic postthoracotomy pain, and Epidemiology of Osteoarthritis. In Osteoarthritis: Diagnosis chronic postmastectomy pain of non-neuropathic origin. The and Medical/Surgical Management, edin 2. Edited by Mosk methods and compositions of the invention employ combi owitz R. W. Howell DS, Goldberg V M. Philadelphia: W B natorial formulations and/or coordinate treatment methods Saunders; 1992: 15-37). Despite the frequency of the disease, wherein an effective amount of bici fadine is administered to the cause is still unknown and there is no cure or effective a patient Suffering from chronic pain in combination with treatment. one or more non-steroidal anti-inflammatory drugs 0005 OA is a chronic and progressive disease which (NSAIDs), wherein the combination of drug treatments is causes damage to afflicted joints and Surrounding tissues. It Sufficient to alleviate one or more targeted chronic pain often develops slowly as the articular cartilage that lies on condition(s) or symptom(s). the ends of bones and forms the articulating surface of the 0009. Within certain embodiments of the invention, joints gradually degenerates. As cartilage degeneration methods for treating chronic pain associated with OA are progresses, secondary changes occur in other tissues in and provided which employ an effective combination of bicifa around the joints including the bone, muscle, ligaments, dine and one or more NSAID(s) sufficient to alleviate one or menisci and synovium. The effect of the failure of cartilage more condition(s) or symptom(s) of OA. tissue and secondary damage to other tissues is that an individual experiences pain, Swelling, weakness and loss of 0010. In other embodiments, the methods and composi functional ability in the afflicted joint(s). Individuals with tions of the invention employing bicifadine in combination OA have pain that typically worsens with weight bearing with one or more NSAID(s) are effective for inhibiting and activity and improves with rest. Many individuals with progression of a chronic pain condition in a mammalian OA develop functional/activity impairments, such as Subject. impaired coordination, and postural and gait defects due to 0011. In a further embodiment, the invention is directed pain and stiffness. These symptoms frequently progress to a to methods and compositions for treating inflammation US 2008/0014272 A1 Jan. 17, 2008 associated with a chronic pain condition, Such as inflamma including, but not limited to, trifumidate; pyrazoles includ tion associated with OA. These methods similarly employ a ing, but not limited to, phenylbutaZone, aminopyrine, anti combination of bici fadine and one or more NSAID(s) suf pyrine, oxyphenbutaZone, and tetrydamine; aminonicotinic ficient to alleviate one or more symptoms of inflammation acids including, but not limited to, flunixin; pyrazolones associated with a chronic pain condition. including, but not limited to phenylbutaZone, feprazone, and apazone. Additional NSAIDs which may be used in the 0012. In another embodiment, the invention is directed to present invention further include, but are not limited to, methods and compositions for treating or preventing a benzindopyrine hydrochloride, benzydamine hydrochloride, disability associated with chronic pain, for example by cinchophen, cintaZone, clonixeril, clonixin, diflumidone reducing or eliminating functional/activity impairment in a Sodium, dimefadane,
Load more

Recommended publications
  • Antinociceptive Effects of Monoamine Reuptake Inhibitors in Assays of Pain-Stimulated and Pain-Depressed Behaviors
    Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2012 Antinociceptive Effects of Monoamine Reuptake Inhibitors in Assays of Pain-Stimulated and Pain-Depressed Behaviors Marisa Rosenberg Virginia Commonwealth University Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Medical Pharmacology Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/2715 This Thesis is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact [email protected]. ANTINOCICEPTIVE EFFECTS OF MONOAMINE REUPTAKE INHIBITORS IN ASSAYS OF PAIN-STIMULATED AND PAIN-DEPRESSED BEHAVIOR A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University By Marisa B. Rosenberg Bachelor of Science, Temple University, 2008 Advisor: Sidney Stevens Negus, Ph.D. Professor, Department of Pharmacology/Toxicology Virginia Commonwealth University Richmond, VA May, 2012 Acknowledgement First and foremost, I’d like to thank my advisor Dr. Steven Negus, whose unwavering support, guidance and patience throughout my graduate career has helped me become the scientist I am today. His dedication to education, learning and the scientific process has instilled in me a quest for knowledge that I will continue to pursue in life. His thoroughness, attention to detail and understanding of pharmacology has been exemplary to a young person like me just starting out in the field of science. I’d also like to thank all of my committee members (Drs.
    [Show full text]
  • Salsalate Tablets, USP 500 Mg and 750 Mg Rx Only
    SALSALATE RX- salsalate tablet, film coated ANDAPharm LLC Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here. ---------- Salsalate Tablets, USP 500 mg and 750 mg Rx Only Cardiovascular Risk NSAIDs may cause an increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (See WARNINGS and CLINICAL TRIALS). Salsalate tablets, USP is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (See WARNINGS). Gastrointestinal Risk NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events. (See WARNINGS). DESCRIPTION Salsalate, is a nonsteroidal anti-inflammatory agent for oral administration. Chemically, salsalate (salicylsalicylic acid or 2-hydroxybenzoic acid, 2-carboxyphenyl ester) is a dimer of salicylic acid; its structural formula is shown below. Chemical Structure: Inactive Ingredients: Colloidal Silicon Dioxide, D&C Yellow #10 Aluminum Lake, Hypromellose, Microcrystalline Cellulose, Sodium Starch Glycolate, Stearic Acid, Talc, Titanium Dioxide, Triacetin. CLINICAL PHARMACOLOGY Salsalate is insoluble in acid gastric fluids (<0.1 mg/mL at pH 1.0), but readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid.
    [Show full text]
  • Download Product Insert (PDF)
    PRODUCT INFORMATION Salsalate Item No. 11911 CAS Registry No.: 552-94-3 Formal Name: 2-hydroxy-2-carboxyphenyl ester- benzoic acid Synonyms: Nobacid, NSC 49171 O MF: C14H10O5 FW: 258.2 O Purity: ≥98% UV/Vis.: λ: 207, 234, 308 nm O max OH HO Supplied as: A crystalline solid Storage: -20°C Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Laboratory Procedures Salsalate is supplied as a crystalline solid. A stock solution may be made by dissolving the salsalate in the solvent of choice, which should be purged with an inert gas. Salsalate is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of salsalate in these solvents is approximately 3, 5, and 14 mg/ml, respectively. Salsalate is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, salsalate should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Salsalate has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Description Salsalate is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of salicylic acid.1 It is converted to salicylic acid by hydrolysis. It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in isolated 2 human whole blood stimulated with LPS (IC50 = 39.9 µM). Salsalate (1,000 mg/kg) inhibits weight gain and decreases fasting plasma glucose and insulin levels, as well as decreases plasma cholesterol and triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat high-cholesterol diet.3 Formulations containing salsalate have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.
    [Show full text]
  • Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types
    (19) TZZ ¥Z_T (11) EP 2 380 595 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.10.2011 Bulletin 2011/43 A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61P 25/00 (2006.01) A61K 49/00 (2006.01) (2006.01) (21) Application number: 10382087.4 A61K 51/00 (22) Date of filing: 19.04.2010 (84) Designated Contracting States: • Alvarado Urbina, Gabriel AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nepean Ontario K2G 4Z1 (CA) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • Bortolozzi Biassoni, Analia Alejandra PT RO SE SI SK SM TR E-08036, Barcelona (ES) Designated Extension States: • Artigas Perez, Francesc AL BA ME RS E-08036, Barcelona (ES) • Vila Bover, Miquel (71) Applicant: Nlife Therapeutics S.L. 15006 La Coruna (ES) E-08035, Barcelona (ES) (72) Inventors: (74) Representative: ABG Patentes, S.L. • Montefeltro, Andrés Pablo Avenida de Burgos 16D E-08014, Barcelon (ES) Edificio Euromor 28036 Madrid (ES) (54) Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types (57) The invention provides a conjugate comprising nucleuc acid toi cell of interests and thus, for the treat- (i) a nucleic acid which is complementary to a target nu- ment of diseases which require a down-regulation of the cleic acid sequence and which expression prevents or protein encoded by the target nucleic acid as well as for reduces expression of the target nucleic acid and (ii) a the delivery of contrast agents to the cells for diagnostic selectivity agent which is capable of binding with high purposes.
    [Show full text]
  • Salicylate, Diflunisal and Their Metabolites Inhibit CBP/P300 and Exhibit Anticancer Activity
    RESEARCH ARTICLE Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity Kotaro Shirakawa1,2,3,4, Lan Wang5,6, Na Man5,6, Jasna Maksimoska7,8, Alexander W Sorum9, Hyung W Lim1,2, Intelly S Lee1,2, Tadahiro Shimazu1,2, John C Newman1,2, Sebastian Schro¨ der1,2, Melanie Ott1,2, Ronen Marmorstein7,8, Jordan Meier9, Stephen Nimer5,6, Eric Verdin1,2* 1Gladstone Institutes, University of California, San Francisco, United States; 2Department of Medicine, University of California, San Francisco, United States; 3Department of Hematology and Oncology, Kyoto University, Kyoto, Japan; 4Graduate School of Medicine, Kyoto University, Kyoto, Japan; 5University of Miami, Gables, United States; 6Sylvester Comprehensive Cancer Center, Miami, United States; 7Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States; 8Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Philadelphia, United States; 9Chemical Biology Laboratory, National Cancer Institute, Frederick, United States Abstract Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-kB activity, and direct activation of AMPK. However, the full spectrum of their activities is incompletely understood. Here we show that salicylate specifically inhibits CBP and p300 lysine acetyltransferase activity in vitro by direct *For correspondence: everdin@ competition with acetyl-Coenzyme A at the catalytic site. We used a chemical structure-similarity gladstone.ucsf.edu search to identify another anti-inflammatory drug, diflunisal, that inhibits p300 more potently than salicylate. At concentrations attainable in human plasma after oral administration, both salicylate Competing interests: The and diflunisal blocked the acetylation of lysine residues on histone and non-histone proteins in cells.
    [Show full text]
  • Medications & Supplements to Avoid Before Procedures
    Medications & Supplements to Avoid Before Procedures Do not ingest any brand of aspirin, or any aspirin-containing medication, any MAO inhibiting, or any serotonin medications, for 14 prior to and 14 days after surgery. Disclose every medication, supplement, ​ ​ etc. With Dr. Rau and your anesthesiologist. Aspirin and aspirin-containing products, as well as some supplements and herbals, may inhibit blood clotting and cause difficulties during and after surgery. If you need an aspirin-free fever reducer and pain reliever, take Tylenol. Also, if you smoke, you must refrain for at least a month prior to a month after your surgery date. Smoking significantly reduces your body’s circulation and vascularity, meaning that your tissues won’t receive all the oxygen needed for proper healing. DIET PILLS, FAT LOSS SUPPLEMENTS AND STACKERS: Please stop taking these pills at least 2 ​ weeks before surgery. Many of these pills contain anticoagulants and can seriously impede your body's ability to clot sufficiently, resulting in hemorrhaging. Many of them also contain ephedra and caffeine, which can affect your anesthetic medications. Remember: if you take antibiotics or if you stop oral contraceptive pills for surgery, use an alternative method of birth control. A Aspirin, Advil, Actifed, Acuprin, Addaprin, Alka Seltzer, Alpha Omega (fish oil), Aluprin, Amitriptyline, Anacin, Ansaid, Anodynos, Analval, Anodynos, Ansaid, Argesic, Arthra-G, Arthralgen, Arthropan, Ascodeen, Ascriptin, Aspir-lox, Asperi-mox, Aspirbuf, Aspercin, Aspergum, Axotal, Azdone,
    [Show full text]
  • Arthritis Treatment Comparison Arthritis Treatment Comparison
    ARTHRITIS TREATMENT COMPARISON ARTHRITIS TREATMENT COMPARISON GENERIC OA of (BRAND) HOW SUPPLIED AS GA JIA JRA OA Knee PsA RA CHELATING AGENTS Penicillamine Cap: 250mg ✓ (Cuprimine) Penicillamine Tab: 250mg ✓ (Depen) CYCLIC POLYPEPTIDE IMMUNOSUPPRESSANTS Cyclosporine Cap: 25mg, 100mg; ✓ (Gengraf, Neoral) Sol: 100mg/mL CYCLOOXYGENASE-2 INHIBITORS Celecoxib Cap: 50mg, 100mg, ✓ ✓ ✓ ✓ (Celebrex) 200mg, 400mg DIHYDROFOLIC ACID REDUCTASE INHIBITORS Methotrexate Inj: 25mg/mL; ✓ ✓ Tab: 2.5mg Methotrexate Tab: 5mg, 7.5mg, ✓ ✓ (Trexall) 10mg, 15mg INTERLEUKIN RECEPTOR ANTAGONISTS Anakinra Inj: 100mg/0.67mL ✓ (Kineret) Tocilizumab Inj: 20mg/mL, ✓ ✓ (Actemra) 162mg/0.9mL GOLD COMPOUNDS Auranofin Cap: 3mg ✓ (Ridaura) Gold sodium thiomalate Inj: 50mg/mL ✓ ✓ (Myochrysine) HYALURONAN AND DERIVATIVES Hyaluronan Inj: 30mg/2mL ✓ (Orthovisc) Sodium hyaluronate Inj: 1% ✓ (Euflexxa) Sodium hyaluronate Inj: 10mg/mL ✓ (Hyalgan) Sodium hyaluronate Inj: 2.5mL ✓ (Supartz) HYLAN POLYMERS Hylan G-F 20 Inj: 8mg/mL ✓ (Synvisc, Synvisc One) KINASE INHIBITORS Tofacitinib Tab: 5mg ✓ (Xeljanz) MONOCLONAL ANTIBODIES Ustekinumab Inj: 45mg/0.5mL, ✓ (Stelara) 90mg/mL MONOCLONAL ANTIBODIES/CD20-BLOCKERS Rituximab Inj: 100mg/10mL, ✓ (Rituxan) 500mg/50mL (Continued) ARTHRITIS TREATMENT COMPARISON GENERIC OA of (BRAND) HOW SUPPLIED AS GA JIA JRA OA Knee PsA RA MONOCLONAL ANTIBODIES/TNF-BLOCKERS Adalimumab Inj: 20mg/0.4mL, ✓ ✓ ✓ ✓ (Humira) 40mg/0.8mL Golimumab Inj: 50mg/0.5mL, ✓ ✓ ✓ (Simponi) 100mg/mL Infliximab Inj: 100mg ✓ ✓ ✓ (Remicade) NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
    [Show full text]
  • List of a FEW of MANY Aspirin-Like Or Herbal Supplement Products To
    1809 E 13th St. Suite 100 -300 Tulsa, OK 74104 (918)582-6800 MEDICATION AND PRODUCTS TO BE AVOIDED PRIOR TO SURGERY **Do not stop taking blood pressure, diabetic, or prescribed medications that are not blood thinners. You will be advised at your pre-op when to stop these medications prior to surgery. If you have any question as to whether it is safe to stop a medication, please check with the prescribing physician. Aspirin and other non-steroidal anti-inflammatory drugs (NSAID’s), such as Motrin are strong anti-coagulants which can cause bleeding problems in normal individuals. In addition to these Aspirin- like medications, Vitamins and many herbal supplements (such as Garlic, Ginkgo, Ginseng, Flaxseed, Ginger, Feverfew, Bilberry, Chamomile, Selenium) can cause bleeding or adverse physiologic effects during surgery. If you are on a blood thinner or antiplatelet medication such as Eliquis, Coumadin (warfarin), Plavix (clopidogrel), Pletal (cilostazol)Pradaxa or Xarelto, you must stop these medications prior to surgery. Please follow the prescribing physician’s recommendation for stopping the medications. Do not restart blood thinners until your physician advises. Patients preparing for surgery must stop all sources of Aspirin, Aspirin like products, Vitamins and all Herbal Supplements or Diet Pills for 7 days prior to surgery and 5 days after surgery. Below are a FEW OF MANY Aspirin-like or Herbal Supplement products to be avoided prior to surgery. Advil Congesprin Chewable Fish Oil Nabumetone Selenium Aggrenox Compounded Creams Flaxseed Nalfon Sine – Aid Aleve Contac Flurbiprofen Naprelan Sine – Off Sinus Alka – Seltzers Cope Four Way Cold Tabs Naprosyn Sinutab Anacin Coricidin Gaysal-S Naproxen SK – 65 Anaprox Cosprin Garlic (Allium Sativum) Neocylate Soma Anadynos Coumadin Gelprin Norgesic Stanback Ansaid Damason P Gemnisin Novnaproxen Stendin APC Darvon Ginger Novodipiradrol St.
    [Show full text]
  • Problems of Drug Dependence 1982 Proceedings of the 44Th Annual Scientific Meeting The
    National Institute Drug Abuse MONOGRAPH SERIES Problems of Drug Dependence 1982 Proceedings of the 44th Annual Scientific Meeting The Committee on Problems of Drug Dependence, Inc. U. S. DEPARTMENT OF HEALTH AND HUMAN SERVICE • Public Health Service • Alcohol, Drug Abuse, and Mental Health Administration Problems of Drug Dependence, 1982 Proceedings of the 44th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Editor, Louis S. Harris, Ph.D. NIDA Research Monograph 43 April 1983 DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse Office of Science 5600 Fishers Lane Rockville, Maryland 20657 NIDA Research Monographs are prepared by the research divisions of the National Institute on Drug Abuse and published by its Office of Science. The primary objective of the series is to provide critical reviews of research problem areas and techniques, the content of state-of-the-art confer- ences, integrative research reviews and significant original research. Its dual publication emphasis is rapid and targeted dissemination to the scientific and professional community. Editorial Advisory Board Avram Goldstein, M.D. Addiction Research Foundation Palo Alto, California Jerome Jaffe, M.D. University of Connecticut School of Medicine Farmington, Connecticut Reese T. Jones, M.D. Langley Porter Neuropsychiatric Institute University of California San Francisco, California Jack Mendelson, M.D. Alcohol and Drug Abuse Research Center Harvard Medical School McLean Hospital Belmont, Massachusetts Helen Nowlis, Ph.D. Rochester, New York Lee Robins, Ph.D. Washington University School of Medicine St. Louis, Missouri NIDA Research Monograph Series William Pollin, M.D.
    [Show full text]
  • S Salsalate Tablets
    SALSALATE TABLETS CARDIOVASCULAR EFFECTS renal disease. If SALSALATE TABLETS therapy must be initiated, Rx Only Cardiovascular Thrombotic Events close monitoring of the patient’s renal function is advisable. Cardiovascular Risk Clinical trials of several COX-2 selective and nonselective NSAIDs Anaphylactoid Reactions • NSAIDs may cause an increased risk of serious cardiovascular of up to three years duration have shown an increased risk of As with other NSAIDs, anaphylactoid reactions may occur in thrombotic events, myocardial infarction, and stroke, which can serious cardiovascular (CV) thrombotic events, myocardial patients without known prior exposure to SALSALATE TABLETS. be fatal. This risk may increase with duration of use. Patients infarction, and stroke, which can be fatal. All NSAIDs, both COX-2 SALSALATE TABLETS should not be given to patients with the with cardiovascular disease or risk factors for cardiovascular selective and nonselective, may have a similar risk. Patients with aspirin triad. This symptom complex typically occurs in asthmatic disease may be at greater risk. (See WARNINGS and CLINICAL known CV disease or risk factors for CV disease may be at greater patients who experience rhinitis with or without nasal polyps, or TRIALS). risk. To minimize the potential risk for an adverse CV event in who exhibit severe, potentially fatal bronchospasm after taking • SALSALATE TABLETS is contraindicated for the treatment of patients treated with an NSAID, the lowest effective dose should be aspirin or other NSAIDs (see CONTRAINDICATIONS and perioperative pain in the setting of coronary artery bypass graft used for the shortest duration possible. Physicians and patients PRECAUTIONS - Preexisting Asthma). Emergency help should be (CABG) surgery (see WARNINGS Gastrointestinal Risk) should remain alert for the development of such events, even in sought in cases where an anaphylactoid reaction occurs.
    [Show full text]
  • Pharmaceutical Appendix to the Tariff Schedule 2
    Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9
    [Show full text]
  • Effect of Targeting Inflammation with Salsalate
    Supplementary Online Content Hauser TH, Salastekar N, Schaefer EJ, et al; Effect of targeting inflammation with salsalate: the TINSAL-CVD randomized clinical trial on progression of coronary plaque in overweight and obese patients using statins. JAMA Cardiol. Published online May 25, 2016. doi:10.1001/jamacardio.2016.0605. eAppendix 1. Supplemental Background eAppendix 2. Additional TINSAL-CVD Study Team in Alphabetical Order Providing Current Contact Information eFigure. Coronary Artery Segment Plaque Assessment Demonstrating [A] Progression and [B] Regression Over 30-Months eTable 1. Primary Endpoint Plaque Volume in Salsalate Versus Placebo Results for the Intention to Treat (ITT) Population (Per Plaque Analysis) eTable 2. Secondary Analysis Plaque Density in Salsalate Versus Placebo Results for the Intention to Treat (ITT) Population (Per Plaque Analysis) eTable 3. Plaque Volume and Plaque Density in Salsalate Versus Placebo Results for the Intention to Treat (ITT) Population (Per Subject Analysis) eTable 4. Plaque Volume and Plaque Density in Salsalate Versus Placebo Results for the Per Protocol Analyses eTable 5. Plaque Volume and Plaque Density in Salsalate Versus Placebo Results for the Participants With Type 2 Diabetes eTable 6. Sensitivity Analyses Using Markov Chain Monte Carlo Method eTable 7. Baseline and Change From Baseline of Clinical and Laboratory Parameters by Treatment Group (SI Units) eTable 8. Serious Adverse Events Occurring After Randomization by Treatment Assignment eTable 9. Cardiac Events by Treatment Assignment eTable 10. Adverse Events Reported by 5% of Total Cohort and Numerically More in Salsalate Than Placebo Treated Group This supplementary material has been provided by the authors to give readers additional information about their work.
    [Show full text]