HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Nat Rev Manuscript Author Drug Discov. Author Manuscript Author manuscript; available in PMC 2019 January 19. Published in final edited form as: Nat Rev Drug Discov. 2018 May ; 17(5): 317–332. doi:10.1038/nrd.2018.14. Unexplored therapeutic opportunities in the human genome Tudor I. Oprea1,2,3,4,*, Cristian G. Bologa1, Søren Brunak4, Allen Campbell5, Gregory N. Gan2, Anna Gaulton6, Shawn M. Gomez7,8, Rajarshi Guha9, Anne Hersey6, Jayme Holmes1, Ajit Jadhav9, Lars Juhl Jensen4, Gary L. Johnson8, Anneli Karlson6,20, Andrew R. Leach6, Avi Ma’ayan10, Anna Malovannaya11, Subramani Mani1, Stephen L. Mathias1, Michael T. McManus12, Terrence F. Meehan6, Christian von Mering13, Daniel Muthas14, Dac-Trung Nguyen9, John P. Overington6,21, George Papadatos6,22, Jun Qin11, Christian Reich15, Bryan L. Roth8, Stephan C. Schürer16, Anton Simeonov9, Larry A. Sklar2,17,18, Noel Southall9, Susumu Tomita19, Ilinca Tudose6,23, Oleg Ursu1, Dušica Vidovic16, Anna Waller17, David Westergaard4, Jeremy J. Yang1, and Gergely Zahoránszky-Köhalmi1,24 1Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA. 2UNM Comprehensive Cancer Center, Albuquerque, NM, USA. 3Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at *
[email protected]. Competing interests The authors declare competing interests: see Web version for details. Publisher’s note Springer Nature remains neutral with regard to jurisdictional