Georgia State University ScholarWorks @ Georgia State University Chemistry Dissertations Department of Chemistry 12-16-2020 Regulation Of Cardiovascular Homeostasis By Autophagy Jing Mu Georgia State University Follow this and additional works at: https://scholarworks.gsu.edu/chemistry_diss Recommended Citation Mu, Jing, "Regulation Of Cardiovascular Homeostasis By Autophagy." Dissertation, Georgia State University, 2020. https://scholarworks.gsu.edu/chemistry_diss/190 This Dissertation is brought to you for free and open access by the Department of Chemistry at ScholarWorks @ Georgia State University. It has been accepted for inclusion in Chemistry Dissertations by an authorized administrator of ScholarWorks @ Georgia State University. For more information, please contact
[email protected]. REGULATION OF CARDIOVASCULAR HOMEOSTASIS BY AUTOPHAGY by JING MU Under the Direction of Ming-hui Zou, MD/PhD ABSTRACT Macroautophagy (hereafter autophagy) is a fundamental cellular process that removes unnecessary or dysfunctional components. It allows the orderly degradation and recycling of cellular components. Mitophagy refers to the selective removal of damaged mitochondria via autophagy pathway. In addition to utilizing core autophagic machinery components, mitophagy exploits a variety of molecules, such as PTEN-induced putative kinase protein 1 (PINK1) and Parkin, to identify and eliminate damaged or superfluous mitochondria. Dysregulation of autophagy and mitophagy contributes to a variety of human disorders, including cardiovascular diseases, such as atherosclerosis and diabetic cardiomyopathy. Vascular smooth muscle cells (VSMCs) are a major component of the vascular media, and are vital for maintaining vessel homeostasis. Migration of VSMCs from the media to intima occurs during the development of atherosclerosis. Although alterations in autophagy activity have been reported in atherosclerosis, further investigation is required to delineate the mechanism by which autophagy regulates microtubule stability and cell migration.