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1 TITLE: 1 BMI Is Negatively Associated with Telomere Length 1 TITLE: 2 BMI is negatively associated with telomere length; a collaborative cross-sectional meta- 3 analysis of 72 observational studies 4 Marij Gielen1, Geja J Hageman2, Evangelia E Antoniou3, Katarina Nordfjall4, Mangino M. 5 Massimo5, 6, Muthuswamy Balasubramanyam7, Tim de Meyer8, Audrey E. Hendricks9, 10, Erik J. 6 Giltay11, Steven C. Hunt12, Jennifer A. Nettleton13, Klelia D. Salpea14, Vanessa A. Diaz15, Ramin 7 Farzaneh-Far16, Gil Atzmon17, Sarah E. Harris18, Lifang Hou19, David Gilley20, Iiris Hovatta21, 22, 8 Sangmi Kim 23, Jeremy D. Kark 24, Hisham Nassar25, David J. Kurz26, Karen A. Mather27, Peter 9 Willeit28, Yun-Ling Zheng29, Sofia Pavanello30, Ellen W. Demerath31, Line Rode32, Daniel 10 Bunout33, Andrew Steptoe34, Lisa Boardman35, Zhao Jinying36, Amelia Marti37, 38, 39, Belinda 11 Needham40, Wei Zheng41, Rosalind Ramsey-Goldman42, Christine Kim Garcia43, 44, Andrew J. 12 Pellatt45, Jaakko Kaprio22, 46, 47, Jonathan N. Hofmann48, Christian Gieger49, Giuseppe Paolisso50, 13 Jacob B.H. Hjelmborg51, Lisa Mirabello45, 48, Teresa Seeman53, Jason Wong54, Katri 14 Savolainen55, Pim Van der Harst56, Linda Broer57, Florian Kronenberg58, Barbara Kollerits58, 15 Timo Strandberg59, Dan T.A. Eisenberg60, Catherine Duggan61, Josine E. Verhoeven62, Roxanne 16 Schaakxs 63, Raffaela Zannolli64, Maurice P. Zeegers1, 65, on behalf of the TELOMAAS group. 17 18 19 Affiliations 20 1NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University 21 Medical Centre, Department of Complex Genetics, Maastricht University, The Netherlands 22 2NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University 23 Medical Centre, Department of Toxicology, Maastricht University, The Netherlands 1 24 3 Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, 25 Maastricht University, The Netherlands 26 4Östersund Hospital, Department of Medicine, Sweden 27 5 Twin Research & Genetic Epidemiology, King’s College London, United Kingdom 28 6 NIHR Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust, London, UK 29 7 Cell and Molecular Biology, Madras Diabetes Research Foundation, Gopalapuram, Chennai, 30 India 31 8 Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Ghent, 32 Belgium 33 9 Population Sciences Branch of the National Heart, Lung, and Blood Institute, NIH, NHLBI's 34 Framingham Heart Study, Framingham, MA, USA 35 10 Department of Mathematical and Statistical Sciences, University of Colorado – Denver, 36 Denver, CO, USA 37 11 Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands 38 12 Cardiovascular Genetics Division, Department of Medicine, University of Utah, Salt Lake 39 City, Utah USA 40 13 Division of Epidemiology, Human Genetics, and Envirionmental Sciences, University of Texas 41 Health Science Center- Houston, Texas, USA 42 14 Department of Molecular Biology and Genetics, B.S.R.C. "Alexander Fleming", Athens, 43 Greece 44 15 Department of Family Medicine, Medical University of South Carolina, Charleston, SC, USA 45 16 Division of Cardiology, San Francisco General Hospital, San Francisco, CA, USA 46 17 Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA. 47 And Department of Biology, Faculty of natural science, University of Haifa, Haifa, Israel. 2 48 18 Centre for Cognitive Ageing and Cognitive Epidemiology, and Medical Genetics Section and 49 Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular 50 Medicine, University of Edenburgh, Edenburgh, United Kingdom 51 19 Department of Preventive Medicine and Robert H. Lurie Comprehensive Cancer center, 52 Feinberg School of Medicine, Northwestern University, Chicago, IL, USA 53 20 Department of Medical and Molecular Genetics, Indiana University School of Medicine, 54 Indianapolis, IN, USA 55 21 Department of Biosciences, University of Helsinki, Helsinki, Finland 56 22 Department of Health, National Institute for Health and Welfare, Helsinki, Finland 57 23 Cancer Prevention and Control Program, Georgia Regents University Cancer Center, Augusta, 58 GA, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research 59 Triangle Park, NC 60 24 Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community 61 Medicine, Jerusalem, Israel 62 25 Department of Cardiology, Hadassah University Medical Center, Jerusalem, Israel 63 26 Department of Cardiology, Triemli Hospital, Zurich, Switzerland 64 27 Centre for Healthy Brain Ageing, Psychiatry, UNSW Australia, Sydney, Australia 65 28 Department of Neurology, Medical University Innsbruck, Innsbruck, Austria, and Department 66 of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom 67 29 Department of Oncology, Georgetown University Medical Center, Georgetown University, 68 Washington DC, USA 69 30 Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, 70 University of Padova, Padova, Italy 3 71 31 Division of Epidemiology and Community Health, University of Minnesota School of Public 72 Health, Minneapolis, MN, USA 73 32 The Copenhagen General Population Study, Dept. of Clinical Biochemistry, Copenhagen 74 University Hospital, Herlev and Gentofte Hospital, Copenhagen, Denmark 75 33 Institute of Nutrition and Food Technology University of Chile, Chile 76 34 Department of Epidemiology and Public Health, University College London, UK. 77 35 Mayo Clinic College of Medicine, Divsion of Gastroenterology and Hepatology, Department 78 of Internal Medicine, Rochester, MN, USA 79 36 Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane 80 University, New Orleans, LA, USA 81 37 Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, 82 Spain 83 38 Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain 84 39 CIBER Fisiopatología de la Obesidad y Nutrición, (CIBERobn), Instituto de Salud Carlos III, 85 Madrid, Spain 86 40 Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA 87 41 Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, 88 Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA 89 42 Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, 90 IL, USA 91 43 Eugene McDermott Center for Human Growth and Development, University of Texas 92 Southwestern Medical Center, Dallas, Texas, USA 93 44 Department of Internal Medicine Division of Pulmonary and Critical Care Medicine, 94 University of Texas Southwestern Medical Center, Dallas, Texas, USA 4 95 45 Department of Medicine, University of Utah, Salt Lake City Utah, USA (currently at Tulane 96 School of Medicine, New Orleans, Lousiana USA) 97 46 Department of Public Health, University of Helsinki, Helsinki, Finland 98 47 Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland 99 48 National Cancer Institute, NIH, Division of Cancer Epidemiology and Genetics, Bethesda, 100 MD, USA 49 Research Unit of Molecular Epidemiology and Institute of Epidemiology II, 101 Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 102 Germany 103 50 Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second 104 University of Naples, Naples, Italy 105 51 Department of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, 106 University of Southern Denmark, Odense C, Denmark 107 53 David Geffen School of Medicine at UCLA, Department of Medicine, Los Angeles, CA, USA 108 54 Stanford University School of Medicine, CA, USA 109 55 Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland 110 56 Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands 111 57 Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands 112 58 Medical University of Innsbruck, Division of Genetic Epidemiology, Department of Medical 113 Genetics, Molecular and Clinical Pharmacology, Innsbruck, Austria 114 59 University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; University 115 of Oulu, Centre for Life Course Epidemiology, Oulu, Finland 116 60 Department of Anthropology and Center for Studies in Demography and Ecology, University 117 of Washington, Seattle WA 98195 118 61 The Fred Hutchinson Cancer Research Center, Seattle, WA, USA 5 119 62 Department of Psychiatry and EMGO Institute for Health and Care Research, VU University 120 Medical Centre, Amsterdam, The Netherlands 121 63 Department of Psychiatry and EMGO Institute for Health and Care Research, VU University 122 Medical Centre, Amsterdam, the Netherlands 123 64 Pediatrics Unit, Azienda Ospedaliera Universitaria, Senese/University of Siena, Policlinico Le 124 Scotte, Siena, Italy 125 65 CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The 126 Netherlands 127 128 Other authors in the TELOMAAS group 129 Göran Roos MD PhD, Umeå Univerisy, Department of Medical Biosciences, Umeå University, 130 Umeå, Sweden 131 Birgitta Stegmayr MD PhD, Umeå Univerisy, Department of Public Health and Clinical 132 Medicine, Sweden 133 Peter Nilsson MD PhD, University Hospital, Malmö, Clinical Sciences Medicine, Sweden 134 Mats Eliasson MD PhD, Sunderbyn Hospital, Luleå, Department of Medicine, Sweden 135 Olle Melander MD PhD, University Hospital, Malmö, Department of
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