Antacid Comparison Chart Description Action Neutralizing effect Protective effect Aluminum hydroxide is an amorphous form of aluminum Aluminum hydroxide is a typical antacid active, very often Aluminum hydroxide in which there is a partial substitution of combined with magnesium hydroxide. Aluminum hydroxide Hydroxide Gels carbonate for hydroxide. On dry basis, it contains the as an antacid is not exactly an aluminum hydroxide (Al(OH)3), equivalent of NLT 76.5% of Al(OH)3, and it may contain it is an aluminum « hydroxy-carbonate » (Al(OH)3-2x (CO3)x, & Powders varying quantities of basic aluminum carbonate and with x within 0.1 to 0.4 where some hydroxides (OH-) are bicarbonate. substituted by carbonates (CO32-). It has an amorphous structure. It is this amorphous structure which allows the acid neutralizing capacity. Side effects: Constipating. Can chelate dietary phosphate, so can potentially deplete phosphate from the stomach. On dry basis magnesium hydroxide, dried at 105°C for Magnesium hydroxide as aluminum hydroxide is a typical Magnesium 2 hours, contains not less than 95.0% and not more antacid active. Both are often combined, offering a good than 100.5% of Mg(OH)2. neutralizing and pH buffering effect and compensating their Hydroxide Gels side effects. It is also used as laxative active (Milk of Magnesia). & Powders Magnesium hydroxide has a crystalline structure. On dry basis calcium carbonate, dried at 200°C for Calcium carbonate is a very reactive antacid active which is Calcium 4 hours, contains not less than 98.5% and not more used alone or in combination with magnesium compounds. Carbonate than 100.5% of CaCO3. It has a crystalline structure and buffering properties. Powders Magaldrate is a chemical combination of aluminum Magaldrate is a basic aluminum and magnesium compound Magaldrate and magnesium hydroxides and sulphate, possessing a layer structure connected by water and sulphate corresponding to the formula: Al5Mg10(OH)31(SO4)2·xH2O. bridges and is crystalline by nature. This unique crystal lattice Gels & It contains the equivalent of not less than 90.0% structure results in the high reactivity for magaldrate. The Powders and not more than 105.0% of Al5Mg10(OH)31(SO4)2, antacid effectiveness of magaldrate can be used to treat peptic calculated on the dried basis. ulcers because it neutralizes gastric acid very quickly while buffering the pH even in presence of proteins and pepsin. Magaldrate can also absorb large quantities of bile acids which prevent these acids from attacking the mucous membranes. Aluminum phosphate gel is a suspension of hydrated Aluminum phosphate (AlPO4) functions by coating the stomach Aluminum AlPO4. Content: 19.0% to 21.0% of AlPO4. wall. It does not neutralize stomach acids. Aluminum phosphate absorbs the bile acids and stomach gas. Since the product does Phosphate not chelate dietary phosphate, it does not deplete phosphate Gel from the stomach. Boehmite gel is a white or almost white, translucent, Boehmite is a crystalline form of aluminum hydroxide. Unlike viscous, colloidal gel of aluminum oxide hydroxide: the amorphous form of aluminum hydroxide gel, boehmite [AlO(OH)]1,nH2O. does not dissolve in hydrochloric acid (HCl). Boehmite protects Boehmite Gel the stomach wall by absorbing stomach acid and creating a “high viscosity gel.” It is chosen primarily because of its lower aluminum solubility. The product, by design, has lower acid neutralizing capacity (ANC) compared to standard aluminum hydroxide gel. www.spipharma.com www.spipharma.com Americas Europe/Middle East/ Africa Asia/Pacific Australia Distribution Company SPI Pharma, Inc. 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