Cross-Tissue Immune Cell Analysis Reveals Tissue-Specific Adaptations and Clonal Architecture 2 Across the Human Body
bioRxiv preprint doi: https://doi.org/10.1101/2021.04.28.441762; this version posted April 28, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. 1 Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture 2 across the human body 3 Authors: 4 Domínguez Conde C1, *, Gomes T 1,*, Jarvis LB2, *, Xu C 1,*, Howlett SK 2, Rainbow DB 2, Suchanek O3 , 5 King HW 4, Mamanova L 1, Polanski K 1, Huang N1 , Fasouli E 1, Mahbubani KT 5, Prete M 1, Campos L 1,6, 6 Mousa HS 2, Needham EJ 2, Pritchard S 1,, Li T 1,, Elmentaite R 1,, Park J 1,, Menon DK 7, Bayraktar OA 1, 7 James LK 4, Meyer KB 1,, Clatworthy MR 1,3, Saeb-Parsy K 5,#, Jones JL 2, #, Teichmann SA 1,8, # 8 Affiliations: 9 1. Wellcome Sanger Institute, Cambridge, UK 10 2. Department of Clinical Neurosciences, University of Cambridge 11 3. Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK 12 4. Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK 13 5. Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research 14 Centre, Cambridge, UK 15 6. West Suffolk Hospital NHS Trust, Bury Saint Edmunds, UK 16 7. Department of Anaesthesia, University of Cambridge, Cambridge, UK 17 8. Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of 18 Cambridge, Cambridge, UK 19 *Co-first authors 20 #Corresponding authors 1 bioRxiv preprint doi: https://doi.org/10.1101/2021.04.28.441762; this version posted April 28, 2021.
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