bioRxiv preprint doi: https://doi.org/10.1101/824466; this version posted October 30, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Spondweni virus causes fetal harm in a mouse model of vertical transmission and is transmitted by Aedes aegypti mosquitoes Anna S. Jaeger1, Andrea M. Weiler2, Ryan V. Moriarty2, Sierra Rybarczyk2, Shelby L. O’Connor2,3, David H. O’Connor2,3, Davis M. Seelig4, Michael K. Fritsch3, Thomas C. Friedrich2,5, and Matthew T. Aliota1* 1Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities. 2Wisconsin National Primate Research Center, University of Wisconsin-Madison. 3Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison. 4Department of Veterinary Clinical Sciences, University of Minnesota, Twin Cities. 5Department of Pathobiological Sciences, University of Wisconsin-Madison. *Correspondence:
[email protected] bioRxiv preprint doi: https://doi.org/10.1101/824466; this version posted October 30, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract Spondweni virus (SPONV) is the most closely related known flavivirus to Zika virus (ZIKV). Its pathogenic potential and vector specificity have not been well defined. SPONV has been found predominantly in Africa, but was recently detected in a pool of Culex quinquefasciatus mosquitoes in Haiti.