Appendix D

D. Combined Drug-Drug Interactions

This list contains all drug-drug interactions (both critical and significant) in National Drug File V. 3.18. The interactions are cross-referenced by each interacting ingredient.

ACEBUTOLOL CRITICAL INTERACTION WITH VERAPAMIL ACEBUTOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH CLONIDINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN ACEBUTOLOL SIGNIFICANT INTERACTION WITH INSULIN ACEBUTOLOL SIGNIFICANT INTERACTION WITH PIROXICAM ACEBUTOLOL SIGNIFICANT INTERACTION WITH SULINDAC ACEBUTOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE ACETAMINOPHEN SIGNIFICANT INTERACTION WITH SULFINPYRAZONE ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH LABETALOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH NADOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH SOTALOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL ALFENTANIL SIGNIFICANT INTERACTION WITH ERYTHROMYCIN ALLOPURINOL CRITICAL INTERACTION WITH AZATHIOPRINE ALLOPURINOL CRITICAL INTERACTION WITH MERCAPTOPURINE ALPRAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE

April 1998 National Drug File V. 3.18 105 User Manual Appendix D

ALPRAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR ALTEPLASE CRITICAL INTERACTION WITH NITROGLYCERIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH TETRACYCLINE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH BETAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH CORTICOTROPIN AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH CORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH COSYNTROPIN AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH DESOXYCORTICOSTERONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH DEXAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH HYDROCORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH METHYLPREDNISOLONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PARAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PREDNISOLONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PREDNISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH TRIAMCINOLONE AMIKACIN SIGNIFICANT INTERACTION WITH AMPICILLIN AMIKACIN SIGNIFICANT INTERACTION WITH ATRACURIUM AMIKACIN SIGNIFICANT INTERACTION WITH BUMETANIDE AMIKACIN SIGNIFICANT INTERACTION WITH CARBENICILLIN AMIKACIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID AMIKACIN SIGNIFICANT INTERACTION WITH FUROSEMIDE AMIKACIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE AMIKACIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE

106 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

AMIKACIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN AMIKACIN SIGNIFICANT INTERACTION WITH PANCURONIUM AMIKACIN SIGNIFICANT INTERACTION WITH PIPERACILLIN AMIKACIN SIGNIFICANT INTERACTION WITH TICARCILLIN AMIKACIN SIGNIFICANT INTERACTION WITH TORSEMIDE AMIKACIN SIGNIFICANT INTERACTION WITH TUBOCURARINE AMIKACIN SIGNIFICANT INTERACTION WITH VANCOMYCIN AMIKACIN SIGNIFICANT INTERACTION WITH VECURONIUM AMILORIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL AMILORIDE SIGNIFICANT INTERACTION WITH CAPTOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH ENALAPRIL AMILORIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH LISINOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM IODIDE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM PHOSPHATE AMILORIDE SIGNIFICANT INTERACTION WITH QUINAPRIL AMILORIDE SIGNIFICANT INTERACTION WITH QUINIDINE AMILORIDE SIGNIFICANT INTERACTION WITH RAMIPRIL AMILORIDE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL AMINOPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE AMINOPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN AMINOPHYLLINE CRITICAL INTERACTION WITH ENOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH ERYTHROMYCIN AMINOPHYLLINE CRITICAL INTERACTION WITH NORFLOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM AMINOPHYLLINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL AMINOPHYLLINE SIGNIFICANT INTERACTION WITH PHENYTOIN AMINOPHYLLINE SIGNIFICANT INTERACTION WITH RIFAMPIN AMIODARONE CRITICAL INTERACTION WITH ANISINDIONE

April 1998 National Drug File V. 3.18 107 User Manual Appendix D

AMIODARONE CRITICAL INTERACTION WITH CYCLOSPORINE AMIODARONE CRITICAL INTERACTION WITH DICUMAROL AMIODARONE CRITICAL INTERACTION WITH DIGITALIS AMIODARONE CRITICAL INTERACTION WITH FENTANYL AMIODARONE CRITICAL INTERACTION WITH PHENPROCOUMON AMIODARONE CRITICAL INTERACTION WITH QUINIDINE AMIODARONE CRITICAL INTERACTION WITH SPARFLOXACIN AMIODARONE CRITICAL INTERACTION WITH WARFARIN AMIODARONE SIGNIFICANT INTERACTION WITH RITONAVIR AMITRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE AMITRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMITRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE AMITRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE AMITRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE AMITRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE AMITRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMITRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE AMOBARBITAL CRITICAL INTERACTION WITH DICUMAROL AMOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON AMOBARBITAL CRITICAL INTERACTION WITH WARFARIN AMOXAPINE CRITICAL INTERACTION WITH CLONIDINE AMOXAPINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMOXAPINE CRITICAL INTERACTION WITH PARGYLINE AMOXAPINE CRITICAL INTERACTION WITH PHENELZINE AMOXAPINE CRITICAL INTERACTION WITH SELEGILINE AMOXAPINE CRITICAL INTERACTION WITH TRANYLCYPROMINE AMOXAPINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMOXAPINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE AMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE AMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE AMPICILLIN SIGNIFICANT INTERACTION WITH AMIKACIN AMPICILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN AMPICILLIN SIGNIFICANT INTERACTION WITH NETILMICIN AMPICILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN ANISINDIONE CRITICAL INTERACTION WITH AMIODARONE

108 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

ANISINDIONE CRITICAL INTERACTION WITH AMOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH ASPIRIN ANISINDIONE CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE ANISINDIONE CRITICAL INTERACTION WITH CARBAMAZEPINE ANISINDIONE CRITICAL INTERACTION WITH CHOLINE SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH CIMETIDINE ANISINDIONE CRITICAL INTERACTION WITH CLOFIBRATE ANISINDIONE CRITICAL INTERACTION WITH DANAZOL ANISINDIONE CRITICAL INTERACTION WITH DISULFIRAM ANISINDIONE CRITICAL INTERACTION WITH FLUCONAZOLE ANISINDIONE CRITICAL INTERACTION WITH ITRACONAZOLE ANISINDIONE CRITICAL INTERACTION WITH KETOCONAZOLE ANISINDIONE CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH MEPHOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH MEPHOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH METHYL SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH MICONAZOLE ANISINDIONE CRITICAL INTERACTION WITH OXYPHENBUTAZONE ANISINDIONE CRITICAL INTERACTION WITH PENTOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH PHENOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH PHENYLBUTAZONE ANISINDIONE CRITICAL INTERACTION WITH PRIMIDONE ANISINDIONE CRITICAL INTERACTION WITH RIFAMPIN ANISINDIONE CRITICAL INTERACTION WITH SALSALATE ANISINDIONE CRITICAL INTERACTION WITH SECOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH SODIUM SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE ANISINDIONE SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE ANISINDIONE SIGNIFICANT INTERACTION WITH DICLOFENAC ANISINDIONE SIGNIFICANT INTERACTION WITH DIFLUNISAL ANISINDIONE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN ANISINDIONE SIGNIFICANT INTERACTION WITH ETODOLAC ANISINDIONE SIGNIFICANT INTERACTION WITH FENOPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH FLURBIPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH IBUPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH INDOMETHACIN ANISINDIONE SIGNIFICANT INTERACTION WITH KETOPROFEN

April 1998 National Drug File V. 3.18 109 User Manual Appendix D

ANISINDIONE SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE ANISINDIONE SIGNIFICANT INTERACTION WITH LEVAMISOLE ANISINDIONE SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID ANISINDIONE SIGNIFICANT INTERACTION WITH MEFENAMIC ACID ANISINDIONE SIGNIFICANT INTERACTION WITH METHIMAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH METRONIDAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH NABUMETONE ANISINDIONE SIGNIFICANT INTERACTION WITH NAPROXEN ANISINDIONE SIGNIFICANT INTERACTION WITH OXAPROZIN ANISINDIONE SIGNIFICANT INTERACTION WITH PAROXETINE ANISINDIONE SIGNIFICANT INTERACTION WITH PHENYTOIN ANISINDIONE SIGNIFICANT INTERACTION WITH PHYTONADIONE ANISINDIONE SIGNIFICANT INTERACTION WITH PIROXICAM ANISINDIONE SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL ANISINDIONE SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH SULFINPYRAZONE ANISINDIONE SIGNIFICANT INTERACTION WITH SULFISOXAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH SULINDAC ANISINDIONE SIGNIFICANT INTERACTION WITH THYROGLOBULIN ANISINDIONE SIGNIFICANT INTERACTION WITH THYROID ANISINDIONE SIGNIFICANT INTERACTION WITH TOLMETIN ANISINDIONE SIGNIFICANT INTERACTION WITH VITAMIN E ANISINDIONE SIGNIFICANT INTERACTION WITH VITAMIN K ASPIRIN CRITICAL INTERACTION WITH ANISINDIONE ASPIRIN CRITICAL INTERACTION WITH DICUMAROL ASPIRIN CRITICAL INTERACTION WITH METHOTREXATE ASPIRIN CRITICAL INTERACTION WITH PHENPROCOUMON ASPIRIN CRITICAL INTERACTION WITH PROBENECID ASPIRIN CRITICAL INTERACTION WITH WARFARIN ASPIRIN SIGNIFICANT INTERACTION WITH HEPARIN ASTEMIZOLE CRITICAL INTERACTION WITH AZITHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH CLARITHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH ERYTHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE ASTEMIZOLE CRITICAL INTERACTION WITH INDINAVIR SULFATE

110 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

ASTEMIZOLE CRITICAL INTERACTION WITH ITRACONAZOLE ASTEMIZOLE CRITICAL INTERACTION WITH KETOCONAZOLE ASTEMIZOLE CRITICAL INTERACTION WITH NEFAZODONE ASTEMIZOLE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ASTEMIZOLE CRITICAL INTERACTION WITH QUININE ASTEMIZOLE CRITICAL INTERACTION WITH RITONAVIR ASTEMIZOLE SIGNIFICANT INTERACTION WITH SOTALOL ATENOLOL CRITICAL INTERACTION WITH VERAPAMIL ATENOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH CLONIDINE ATENOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE ATENOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ATENOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE ATENOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE ATENOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN ATENOLOL SIGNIFICANT INTERACTION WITH INSULIN ATENOLOL SIGNIFICANT INTERACTION WITH PIROXICAM ATENOLOL SIGNIFICANT INTERACTION WITH SULINDAC ATENOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE ATOVAQUONE SIGNIFICANT INTERACTION WITH ZIDOVUDINE ATRACURIUM SIGNIFICANT INTERACTION WITH AMIKACIN ATRACURIUM SIGNIFICANT INTERACTION WITH GENTAMICIN ATRACURIUM SIGNIFICANT INTERACTION WITH NEOMYCIN ATRACURIUM SIGNIFICANT INTERACTION WITH NETILMICIN ATRACURIUM SIGNIFICANT INTERACTION WITH STREPTOMYCIN ATRACURIUM SIGNIFICANT INTERACTION WITH TOBRAMYCIN ATROPINE SIGNIFICANT INTERACTION WITH CISAPRIDE AZATHIOPRINE CRITICAL INTERACTION WITH ALLOPURINOL AZITHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE AZITHROMYCIN CRITICAL INTERACTION WITH ERGOT AZITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE AZITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE AZITHROMYCIN CRITICAL INTERACTION WITH TERFENADINE BENAZEPRIL SIGNIFICANT INTERACTION WITH AMILORIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID

April 1998 National Drug File V. 3.18 111 User Manual Appendix D

BENAZEPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN BENAZEPRIL SIGNIFICANT INTERACTION WITH LITHIUM BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE BENAZEPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE BENAZEPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE BENDROFLUMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM BENDROFLUMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS BENZPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID BENZPHETAMINE CRITICAL INTERACTION WITH PARGYLINE BENZPHETAMINE CRITICAL INTERACTION WITH PHENELZINE BENZPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE BENZTHIAZIDE CRITICAL INTERACTION WITH LITHIUM BENZTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS BEPRIDIL SIGNIFICANT INTERACTION WITH RITONAVIR BETAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE BETAMETHASONE SIGNIFICANT INTERACTION WITH EDROPHONIUM BETAMETHASONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE BETAMETHASONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE BETAMETHASONE SIGNIFICANT INTERACTION WITH RIFABUTIN BETAMETHASONE SIGNIFICANT INTERACTION WITH RIFAMPIN BETAXOLOL CRITICAL INTERACTION WITH VERAPAMIL BETAXOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE BETAXOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE BETAXOLOL SIGNIFICANT INTERACTION WITH CLONIDINE BETAXOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE BETAXOLOL SIGNIFICANT INTERACTION WITH FELODIPINE BETAXOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE BETAXOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE BETAXOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN BETAXOLOL SIGNIFICANT INTERACTION WITH INSULIN BETAXOLOL SIGNIFICANT INTERACTION WITH PIROXICAM BETAXOLOL SIGNIFICANT INTERACTION WITH SULINDAC BETAXOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE

112 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

BETAXOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH ANISINDIONE BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH DICUMAROL BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH WARFARIN BISMUTH SUBSALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN BISMUTH SUBSALICYLATE SIGNIFICANT INTERACTION WITH METHOTREXATE BISOPROLOL FUMARATE CRITICAL INTERACTION WITH VERAPAMIL BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH CIMETIDINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH EPINEPHRINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH FELODIPINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH GLIPIZIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH GLYBURIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH INDOMETHACIN BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH INSULIN BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH PIROXICAM BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH SULINDAC BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH TOLAZAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH TOLBUTAMIDE BROMOCRIPTINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN BROMOCRIPTINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE BROMOCRIPTINE SIGNIFICANT INTERACTION WITH PHENYLPROPANOLAMINE BUMETANIDE SIGNIFICANT INTERACTION WITH AMIKACIN BUMETANIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH DIGITALIS BUMETANIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH GENTAMICIN BUMETANIDE SIGNIFICANT INTERACTION WITH KANAMYCIN BUMETANIDE SIGNIFICANT INTERACTION WITH NETILMICIN BUMETANIDE SIGNIFICANT INTERACTION WITH QUINAPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH RAMIPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN BUMETANIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN BUPROPION SIGNIFICANT INTERACTION WITH CARBAMAZEPINE BUTABARBITAL SIGNIFICANT INTERACTION WITH DICUMAROL BUTALBITAL SIGNIFICANT INTERACTION WITH DICUMAROL

April 1998 National Drug File V. 3.18 113 User Manual Appendix D

BUTALBITAL SIGNIFICANT INTERACTION WITH WARFARIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE CAPTOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE CAPTOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN CAPTOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE CAPTOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE CARBAMAZEPINE CRITICAL INTERACTION WITH ANISINDIONE CARBAMAZEPINE CRITICAL INTERACTION WITH CYCLOSPORINE CARBAMAZEPINE CRITICAL INTERACTION WITH DESOGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH DICUMAROL CARBAMAZEPINE CRITICAL INTERACTION WITH ETHINYL ESTRADIOL CARBAMAZEPINE CRITICAL INTERACTION WITH ETHYNODIOL DIACETATE CARBAMAZEPINE CRITICAL INTERACTION WITH ISONIAZID CARBAMAZEPINE CRITICAL INTERACTION WITH LEVONORGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH MEDROXYPROGESTERONE CARBAMAZEPINE CRITICAL INTERACTION WITH MESTRANOL CARBAMAZEPINE CRITICAL INTERACTION WITH NORETHINDRONE CARBAMAZEPINE CRITICAL INTERACTION WITH NORETHYNODREL CARBAMAZEPINE CRITICAL INTERACTION WITH NORGESTIMATE CARBAMAZEPINE CRITICAL INTERACTION WITH NORGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH PHENPROCOUMON CARBAMAZEPINE CRITICAL INTERACTION WITH WARFARIN CARBAMAZEPINE SIGNIFICANT INTERACTION WITH BUPROPION CARBAMAZEPINE SIGNIFICANT INTERACTION WITH CLARITHROMYCIN CARBAMAZEPINE SIGNIFICANT INTERACTION WITH DANAZOL CARBAMAZEPINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN CARBAMAZEPINE SIGNIFICANT INTERACTION WITH FELBAMATE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH FELODIPINE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH ITRACONAZOLE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CARBAMAZEPINE SIGNIFICANT INTERACTION WITH PROPOXYPHENE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH VERAPAMIL CARBENICILLIN SIGNIFICANT INTERACTION WITH AMIKACIN CARBENICILLIN SIGNIFICANT INTERACTION WITH DEMECLOCYCLINE

114 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

CARBENICILLIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN CARBENICILLIN SIGNIFICANT INTERACTION WITH MINOCYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH NETILMICIN CARBENICILLIN SIGNIFICANT INTERACTION WITH OXYTETRACYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH TETRACYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN CARMUSTINE CRITICAL INTERACTION WITH CIMETIDINE CARTEOLOL CRITICAL INTERACTION WITH VERAPAMIL CARTEOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE CARTEOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE CARTEOLOL SIGNIFICANT INTERACTION WITH CLONIDINE CARTEOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE CARTEOLOL SIGNIFICANT INTERACTION WITH FELODIPINE CARTEOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE CARTEOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE CARTEOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN CARTEOLOL SIGNIFICANT INTERACTION WITH INSULIN CARTEOLOL SIGNIFICANT INTERACTION WITH PIROXICAM CARTEOLOL SIGNIFICANT INTERACTION WITH SULINDAC CARTEOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE CARTEOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE CHLORAMPHENICOL SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM CHLORAMPHENICOL SIGNIFICANT INTERACTION WITH PHENYTOIN CHLORDIAZEPOXIDE SIGNIFICANT INTERACTION WITH CLOZAPINE CHLORDIAZEPOXIDE SIGNIFICANT INTERACTION WITH RITONAVIR CHLOROQUINE SIGNIFICANT INTERACTION WITH CYCLOSPORINE CHLOROQUINE SIGNIFICANT INTERACTION WITH PRAZIQUANTEL CHLOROTHIAZIDE CRITICAL INTERACTION WITH LITHIUM CHLOROTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS CHLORPROMAZINE SIGNIFICANT INTERACTION WITH MEPERIDINE CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH LABETALOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL

April 1998 National Drug File V. 3.18 115 User Manual Appendix D

CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH NADOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH SOTALOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL CHLORTHALIDONE CRITICAL INTERACTION WITH LITHIUM CHLORTHALIDONE SIGNIFICANT INTERACTION WITH DIGITALIS CHLORZOXAZONE SIGNIFICANT INTERACTION WITH DISULFIRAM CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH ANISINDIONE CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH DICUMAROL CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH DIGITALIS CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH WARFARIN CHOLINE SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE CHOLINE SALICYLATE CRITICAL INTERACTION WITH DICUMAROL CHOLINE SALICYLATE CRITICAL INTERACTION WITH METHOTREXATE CHOLINE SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON CHOLINE SALICYLATE CRITICAL INTERACTION WITH WARFARIN CHOLINE SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN CIMETIDINE CRITICAL INTERACTION WITH AMINOPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH ANISINDIONE CIMETIDINE CRITICAL INTERACTION WITH CARMUSTINE CIMETIDINE CRITICAL INTERACTION WITH DICUMAROL CIMETIDINE CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM CIMETIDINE CRITICAL INTERACTION WITH OXTRIPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH PHENPROCOUMON CIMETIDINE CRITICAL INTERACTION WITH PHENYTOIN CIMETIDINE CRITICAL INTERACTION WITH THEOPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH WARFARIN CIMETIDINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE CIMETIDINE SIGNIFICANT INTERACTION WITH CLOZAPINE CIMETIDINE SIGNIFICANT INTERACTION WITH ENOXACIN CIMETIDINE SIGNIFICANT INTERACTION WITH METOPROLOL CIMETIDINE SIGNIFICANT INTERACTION WITH PAROXETINE CIMETIDINE SIGNIFICANT INTERACTION WITH PROPRANOLOL CIMETIDINE SIGNIFICANT INTERACTION WITH TACRINE HYDROCHLORIDE CIMETIDINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE

116 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

CIPROFLOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE CIPROFLOXACIN CRITICAL INTERACTION WITH OXTRIPHYLLINE CIPROFLOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH IRON CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE CISAPRIDE CRITICAL INTERACTION WITH CLARITHROMYCIN CISAPRIDE CRITICAL INTERACTION WITH ERYTHROMYCIN CISAPRIDE CRITICAL INTERACTION WITH FLUCONAZOLE CISAPRIDE CRITICAL INTERACTION WITH INDINAVIR SULFATE CISAPRIDE CRITICAL INTERACTION WITH ITRACONAZOLE CISAPRIDE CRITICAL INTERACTION WITH KETOCONAZOLE CISAPRIDE CRITICAL INTERACTION WITH MICONAZOLE CISAPRIDE CRITICAL INTERACTION WITH NEFAZODONE CISAPRIDE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CISAPRIDE CRITICAL INTERACTION WITH RITONAVIR CISAPRIDE SIGNIFICANT INTERACTION WITH ATROPINE CLARITHROMYCIN CRITICAL INTERACTION WITH AMINOPHYLLINE CLARITHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE CLARITHROMYCIN CRITICAL INTERACTION WITH CISAPRIDE CLARITHROMYCIN CRITICAL INTERACTION WITH CYCLOSPORINE CLARITHROMYCIN CRITICAL INTERACTION WITH DIGITALIS CLARITHROMYCIN CRITICAL INTERACTION WITH ERGOT CLARITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE CLARITHROMYCIN CRITICAL INTERACTION WITH OXTRIPHYLLINE CLARITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE CLARITHROMYCIN CRITICAL INTERACTION WITH TERFENADINE

April 1998 National Drug File V. 3.18 117 User Manual Appendix D

CLARITHROMYCIN CRITICAL INTERACTION WITH THEOPHYLLINE CLARITHROMYCIN SIGNIFICANT INTERACTION WITH CARBAMAZEPINE CLARITHROMYCIN SIGNIFICANT INTERACTION WITH TACROLIMUS CLOFIBRATE CRITICAL INTERACTION WITH ANISINDIONE CLOFIBRATE CRITICAL INTERACTION WITH DICUMAROL CLOFIBRATE CRITICAL INTERACTION WITH PHENPROCOUMON CLOFIBRATE CRITICAL INTERACTION WITH WARFARIN CLOMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE CLOMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID CLOMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE CLOMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE CLOMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE CLOMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE CLOMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE CLOMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE CLONAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE CLONAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR CLONIDINE CRITICAL INTERACTION WITH AMITRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH AMOXAPINE CLONIDINE CRITICAL INTERACTION WITH CLOMIPRAMINE CLONIDINE CRITICAL INTERACTION WITH DESIPRAMINE CLONIDINE CRITICAL INTERACTION WITH DOXEPIN CLONIDINE CRITICAL INTERACTION WITH IMIPRAMINE CLONIDINE CRITICAL INTERACTION WITH NORTRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH PROTRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH TRIMIPRAMINE CLONIDINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL CLONIDINE SIGNIFICANT INTERACTION WITH ATENOLOL CLONIDINE SIGNIFICANT INTERACTION WITH BETAXOLOL CLONIDINE SIGNIFICANT INTERACTION WITH CARTEOLOL CLONIDINE SIGNIFICANT INTERACTION WITH METOPROLOL CLONIDINE SIGNIFICANT INTERACTION WITH NADOLOL CLONIDINE SIGNIFICANT INTERACTION WITH PENBUTOLOL CLONIDINE SIGNIFICANT INTERACTION WITH PINDOLOL CLONIDINE SIGNIFICANT INTERACTION WITH PROPRANOLOL CLONIDINE SIGNIFICANT INTERACTION WITH TIMOLOL CLORAZEPATE SIGNIFICANT INTERACTION WITH CLOZAPINE CLORAZEPATE SIGNIFICANT INTERACTION WITH RITONAVIR

118 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

CLOZAPINE SIGNIFICANT INTERACTION WITH ALPRAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH CHLORDIAZEPOXIDE CLOZAPINE SIGNIFICANT INTERACTION WITH CIMETIDINE CLOZAPINE SIGNIFICANT INTERACTION WITH CLONAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH CLORAZEPATE CLOZAPINE SIGNIFICANT INTERACTION WITH DIAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN CLOZAPINE SIGNIFICANT INTERACTION WITH ESTAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH FLURAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE CLOZAPINE SIGNIFICANT INTERACTION WITH HALAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH LORAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH MEPERIDINE CLOZAPINE SIGNIFICANT INTERACTION WITH MIDAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH OXAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH PRAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH QUAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH RITONAVIR CLOZAPINE SIGNIFICANT INTERACTION WITH TEMAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH TRIAZOLAM COLCHICINE CRITICAL INTERACTION WITH CYCLOSPORINE COLCHICINE CRITICAL INTERACTION WITH ERYTHROMYCIN CORTICOTROPIN SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN COSYNTROPIN SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CYCLOSPORINE CRITICAL INTERACTION WITH AMIODARONE CYCLOSPORINE CRITICAL INTERACTION WITH CARBAMAZEPINE CYCLOSPORINE CRITICAL INTERACTION WITH CLARITHROMYCIN CYCLOSPORINE CRITICAL INTERACTION WITH COLCHICINE CYCLOSPORINE CRITICAL INTERACTION WITH DILTIAZEM CYCLOSPORINE CRITICAL INTERACTION WITH ERGOT CYCLOSPORINE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE CYCLOSPORINE CRITICAL INTERACTION WITH ERYTHROMYCIN CYCLOSPORINE CRITICAL INTERACTION WITH ETHOTOIN CYCLOSPORINE CRITICAL INTERACTION WITH ETOPOSIDE CYCLOSPORINE CRITICAL INTERACTION WITH FLUCONAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH FOSCARNET

April 1998 National Drug File V. 3.18 119 User Manual Appendix D

CYCLOSPORINE CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM CYCLOSPORINE CRITICAL INTERACTION WITH ITRACONAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH MEPHENYTOIN CYCLOSPORINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CYCLOSPORINE CRITICAL INTERACTION WITH PHENYTOIN CYCLOSPORINE CRITICAL INTERACTION WITH RIFABUTIN CYCLOSPORINE CRITICAL INTERACTION WITH RIFAMPIN CYCLOSPORINE CRITICAL INTERACTION WITH SULFACYTINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFADIAZINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFAMETHIZOLE CYCLOSPORINE CRITICAL INTERACTION WITH SULFAMETHOXAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH SULFASALAZINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFISOXAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH VERAPAMIL CYCLOSPORINE SIGNIFICANT INTERACTION WITH CHLOROQUINE CYCLOSPORINE SIGNIFICANT INTERACTION WITH DANAZOL CYCLOSPORINE SIGNIFICANT INTERACTION WITH DIGITALIS CYCLOSPORINE SIGNIFICANT INTERACTION WITH IMIPENEM CYCLOSPORINE SIGNIFICANT INTERACTION WITH KETOCONAZOLE CYCLOSPORINE SIGNIFICANT INTERACTION WITH LOVASTATIN CYCLOSPORINE SIGNIFICANT INTERACTION WITH METOCLOPRAMIDE CYCLOSPORINE SIGNIFICANT INTERACTION WITH TACROLIMUS CYCLOSPORINE SIGNIFICANT INTERACTION WITH TICLOPIDINE CYCLOSPORINE SIGNIFICANT INTERACTION WITH TRIMETHOPRIM CYCLOTHIAZIDE CRITICAL INTERACTION WITH LITHIUM CYCLOTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS CYPROHEPTADINE SIGNIFICANT INTERACTION WITH FLUOXETINE CYPROHEPTADINE SIGNIFICANT INTERACTION WITH PAROXETINE DANAZOL CRITICAL INTERACTION WITH ANISINDIONE DANAZOL CRITICAL INTERACTION WITH DICUMAROL DANAZOL CRITICAL INTERACTION WITH PHENPROCOUMON DANAZOL SIGNIFICANT INTERACTION WITH CARBAMAZEPINE DANAZOL SIGNIFICANT INTERACTION WITH CYCLOSPORINE DANAZOL SIGNIFICANT INTERACTION WITH TACROLIMUS DAPSONE CRITICAL INTERACTION WITH DIDANOSINE DEMECLOCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN DEMECLOCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS DESFLURANE SIGNIFICANT INTERACTION WITH LABETALOL

120 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

DESIPRAMINE CRITICAL INTERACTION WITH CLONIDINE DESIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DESIPRAMINE CRITICAL INTERACTION WITH PARGYLINE DESIPRAMINE CRITICAL INTERACTION WITH PHENELZINE DESIPRAMINE CRITICAL INTERACTION WITH SELEGILINE DESIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DESIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE DESIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE DESOGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE DESOGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN DESOGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN DESOXYCORTICOSTERONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE DEXAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE DEXAMETHASONE SIGNIFICANT INTERACTION WITH RIFAMPIN DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PHENELZINE DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH SELEGILINE DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE DEXTROAMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DEXTROAMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE DEXTROAMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE DEXTROAMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH ISOCARBOXAZID DEXTROMETHORPHAN CRITICAL INTERACTION WITH PARGYLINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH PHENELZINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH TRANYLCYPROMINE DEXTROMETHORPHAN SIGNIFICANT INTERACTION WITH PAROXETINE DIAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE DIAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR DICLOFENAC SIGNIFICANT INTERACTION WITH ANISINDIONE DICLOFENAC SIGNIFICANT INTERACTION WITH DICUMAROL DICLOFENAC SIGNIFICANT INTERACTION WITH METHOTREXATE DICLOFENAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON DICLOFENAC SIGNIFICANT INTERACTION WITH WARFARIN DICUMAROL CRITICAL INTERACTION WITH AMIODARONE DICUMAROL CRITICAL INTERACTION WITH AMOBARBITAL DICUMAROL CRITICAL INTERACTION WITH ASPIRIN DICUMAROL CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE

April 1998 National Drug File V. 3.18 121 User Manual Appendix D

DICUMAROL CRITICAL INTERACTION WITH CARBAMAZEPINE DICUMAROL CRITICAL INTERACTION WITH CHOLINE SALICYLATE DICUMAROL CRITICAL INTERACTION WITH CIMETIDINE DICUMAROL CRITICAL INTERACTION WITH CLOFIBRATE DICUMAROL CRITICAL INTERACTION WITH DANAZOL DICUMAROL CRITICAL INTERACTION WITH DISULFIRAM DICUMAROL CRITICAL INTERACTION WITH FLUCONAZOLE DICUMAROL CRITICAL INTERACTION WITH ITRACONAZOLE DICUMAROL CRITICAL INTERACTION WITH KETOCONAZOLE DICUMAROL CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE DICUMAROL CRITICAL INTERACTION WITH MEPHOBARBITAL DICUMAROL CRITICAL INTERACTION WITH METHYL SALICYLATE DICUMAROL CRITICAL INTERACTION WITH MICONAZOLE DICUMAROL CRITICAL INTERACTION WITH OXYPHENBUTAZONE DICUMAROL CRITICAL INTERACTION WITH PENTOBARBITAL DICUMAROL CRITICAL INTERACTION WITH PHENOBARBITAL DICUMAROL CRITICAL INTERACTION WITH PHENYLBUTAZONE DICUMAROL CRITICAL INTERACTION WITH PRIMIDONE DICUMAROL CRITICAL INTERACTION WITH RIFAMPIN DICUMAROL CRITICAL INTERACTION WITH SALSALATE DICUMAROL CRITICAL INTERACTION WITH SECOBARBITAL DICUMAROL CRITICAL INTERACTION WITH SODIUM SALICYLATE DICUMAROL CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE DICUMAROL SIGNIFICANT INTERACTION WITH BUTABARBITAL DICUMAROL SIGNIFICANT INTERACTION WITH BUTALBITAL DICUMAROL SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE DICUMAROL SIGNIFICANT INTERACTION WITH DICLOFENAC DICUMAROL SIGNIFICANT INTERACTION WITH DIFLUNISAL DICUMAROL SIGNIFICANT INTERACTION WITH ERYTHROMYCIN DICUMAROL SIGNIFICANT INTERACTION WITH ETODOLAC DICUMAROL SIGNIFICANT INTERACTION WITH FENOPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH FLURBIPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH IBUPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH INDOMETHACIN DICUMAROL SIGNIFICANT INTERACTION WITH KETOPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE DICUMAROL SIGNIFICANT INTERACTION WITH LEVAMISOLE

122 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

DICUMAROL SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID DICUMAROL SIGNIFICANT INTERACTION WITH MEFENAMIC ACID DICUMAROL SIGNIFICANT INTERACTION WITH METHIMAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH METRONIDAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH NABUMETONE DICUMAROL SIGNIFICANT INTERACTION WITH NAPROXEN DICUMAROL SIGNIFICANT INTERACTION WITH OXAPROZIN DICUMAROL SIGNIFICANT INTERACTION WITH PAROXETINE DICUMAROL SIGNIFICANT INTERACTION WITH PHENYTOIN DICUMAROL SIGNIFICANT INTERACTION WITH PHYTONADIONE DICUMAROL SIGNIFICANT INTERACTION WITH PIROXICAM DICUMAROL SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL DICUMAROL SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH SULFINPYRAZONE DICUMAROL SIGNIFICANT INTERACTION WITH SULFISOXAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH SULINDAC DICUMAROL SIGNIFICANT INTERACTION WITH THYROGLOBULIN DICUMAROL SIGNIFICANT INTERACTION WITH THYROID DICUMAROL SIGNIFICANT INTERACTION WITH TOLMETIN DICUMAROL SIGNIFICANT INTERACTION WITH VITAMIN E DICUMAROL SIGNIFICANT INTERACTION WITH VITAMIN K DIDANOSINE CRITICAL INTERACTION WITH DAPSONE DIDANOSINE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH ENOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH GANCICLOVIR DIDANOSINE SIGNIFICANT INTERACTION WITH ITRACONAZOLE DIDANOSINE SIGNIFICANT INTERACTION WITH KETOCONAZOLE DIDANOSINE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH NORFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH OFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH TETRACYCLINE DIDANOSINE SIGNIFICANT INTERACTION WITH ZALCITABINE (DIDEOXYCYTIDINE,ddC) DIETHYLPROPION CRITICAL INTERACTION WITH ISOCARBOXAZID DIETHYLPROPION CRITICAL INTERACTION WITH PARGYLINE DIETHYLPROPION CRITICAL INTERACTION WITH PHENELZINE

April 1998 National Drug File V. 3.18 123 User Manual Appendix D

DIETHYLPROPION CRITICAL INTERACTION WITH TRANYLCYPROMINE DIFLUNISAL SIGNIFICANT INTERACTION WITH ANISINDIONE DIFLUNISAL SIGNIFICANT INTERACTION WITH DICUMAROL DIFLUNISAL SIGNIFICANT INTERACTION WITH PHENPROCOUMON DIFLUNISAL SIGNIFICANT INTERACTION WITH PROBENECID DIFLUNISAL SIGNIFICANT INTERACTION WITH WARFARIN DIGITALIS CRITICAL INTERACTION WITH AMIODARONE DIGITALIS CRITICAL INTERACTION WITH CLARITHROMYCIN DIGITALIS CRITICAL INTERACTION WITH ERYTHROMYCIN DIGITALIS CRITICAL INTERACTION WITH VERAPAMIL DIGITALIS SIGNIFICANT INTERACTION WITH BENDROFLUMETHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH BENZTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH BUMETANIDE DIGITALIS SIGNIFICANT INTERACTION WITH CHLOROTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH CHLORTHALIDONE DIGITALIS SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE DIGITALIS SIGNIFICANT INTERACTION WITH CYCLOSPORINE DIGITALIS SIGNIFICANT INTERACTION WITH CYCLOTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH DEMECLOCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH DOXYCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID DIGITALIS SIGNIFICANT INTERACTION WITH FUROSEMIDE DIGITALIS SIGNIFICANT INTERACTION WITH HYDROCHLOROTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH HYDROFLUMETHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH INDAPAMIDE DIGITALIS SIGNIFICANT INTERACTION WITH METHYCLOTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH METOLAZONE DIGITALIS SIGNIFICANT INTERACTION WITH MINOCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH OXYTETRACYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH POLYTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH PROPAFENONE DIGITALIS SIGNIFICANT INTERACTION WITH QUINETHAZONE DIGITALIS SIGNIFICANT INTERACTION WITH QUINIDINE DIGITALIS SIGNIFICANT INTERACTION WITH TETRACYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH TRICHLORMETHIAZIDE DIHYDROXYALUMINUM SODIUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN DIHYDROXYALUMINUM SODIUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN DILTIAZEM CRITICAL INTERACTION WITH CYCLOSPORINE

124 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

DILTIAZEM SIGNIFICANT INTERACTION WITH THEOPHYLLINE DIRITHROMYCIN CRITICAL INTERACTION WITH ERGOT DIRITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE DIRITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE DISOPYRAMIDE CRITICAL INTERACTION WITH SPARFLOXACIN DISULFIRAM CRITICAL INTERACTION WITH ANISINDIONE DISULFIRAM CRITICAL INTERACTION WITH DICUMAROL DISULFIRAM CRITICAL INTERACTION WITH PHENPROCOUMON DISULFIRAM CRITICAL INTERACTION WITH WARFARIN DISULFIRAM SIGNIFICANT INTERACTION WITH CHLORZOXAZONE DISULFIRAM SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM DISULFIRAM SIGNIFICANT INTERACTION WITH PHENYTOIN DOPAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DOPAMINE CRITICAL INTERACTION WITH PARGYLINE DOPAMINE CRITICAL INTERACTION WITH PHENELZINE DOPAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DOXEPIN CRITICAL INTERACTION WITH CLONIDINE DOXEPIN CRITICAL INTERACTION WITH ISOCARBOXAZID DOXEPIN CRITICAL INTERACTION WITH PARGYLINE DOXEPIN CRITICAL INTERACTION WITH PHENELZINE DOXEPIN CRITICAL INTERACTION WITH SELEGILINE DOXEPIN CRITICAL INTERACTION WITH TRANYLCYPROMINE DOXEPIN SIGNIFICANT INTERACTION WITH FLUOXETINE DOXEPIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN DOXYCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS DOXYCYCLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGALDRATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH PHENYTOIN DOXYCYCLINE SIGNIFICANT INTERACTION WITH RIFAMPIN EDROPHONIUM SIGNIFICANT INTERACTION WITH BETAMETHASONE

April 1998 National Drug File V. 3.18 125 User Manual Appendix D

ENALAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE ENALAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN ENALAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE ENALAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE ENCAINIDE SIGNIFICANT INTERACTION WITH RITONAVIR ENFLURANE SIGNIFICANT INTERACTION WITH ISONIAZID ENFLURANE SIGNIFICANT INTERACTION WITH LABETALOL ENOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE ENOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE ENOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH CIMETIDINE ENOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE ENOXACIN SIGNIFICANT INTERACTION WITH DIHYDROXYALUMINUM SODIUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH FAMOTIDINE ENOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE ENOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE ENOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE ENOXACIN SIGNIFICANT INTERACTION WITH NIZATIDINE ENOXACIN SIGNIFICANT INTERACTION WITH RANITIDINE ENOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE EPHEDRINE CRITICAL INTERACTION WITH ISOCARBOXAZID EPHEDRINE CRITICAL INTERACTION WITH PARGYLINE EPHEDRINE CRITICAL INTERACTION WITH PHENELZINE EPHEDRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE EPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE EPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM ACETATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM CITRATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM LACTATE EPHEDRINE SIGNIFICANT INTERACTION WITH TROMETHAMINE EPINEPHRINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH ATENOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH BETAXOLOL

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EPINEPHRINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE EPINEPHRINE SIGNIFICANT INTERACTION WITH CARTEOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH LABETALOL EPINEPHRINE SIGNIFICANT INTERACTION WITH METOPROLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH NADOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PENBUTOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PINDOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PROPRANOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH SOTALOL EPINEPHRINE SIGNIFICANT INTERACTION WITH TIMOLOL ERGOT CRITICAL INTERACTION WITH AZITHROMYCIN ERGOT CRITICAL INTERACTION WITH CLARITHROMYCIN ERGOT CRITICAL INTERACTION WITH CYCLOSPORINE ERGOT CRITICAL INTERACTION WITH DIRITHROMYCIN ERGOT CRITICAL INTERACTION WITH ERYTHROMYCIN ERGOT CRITICAL INTERACTION WITH FENFLURAMINE ERGOT CRITICAL INTERACTION WITH NITROGLYCERIN ERGOT CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ERGOT CRITICAL INTERACTION WITH PROPRANOLOL ERGOT CRITICAL INTERACTION WITH SUMATRIPTAN ERGOT CRITICAL INTERACTION WITH SUMATRIPTAN SUCCINATE ERGOT CRITICAL INTERACTION WITH TACROLIMUS ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH AZITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH CLARITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH CYCLOSPORINE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH DIRITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH ERYTHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH FENFLURAMINE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH NITROGLYCERIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH PROPRANOLOL ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH SUMATRIPTAN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH SUMATRIPTAN SUCCINATE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH TACROLIMUS ERYTHROMYCIN CRITICAL INTERACTION WITH AMINOPHYLLINE ERYTHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE ERYTHROMYCIN CRITICAL INTERACTION WITH CISAPRIDE ERYTHROMYCIN CRITICAL INTERACTION WITH COLCHICINE

April 1998 National Drug File V. 3.18 127 User Manual Appendix D

ERYTHROMYCIN CRITICAL INTERACTION WITH CYCLOSPORINE ERYTHROMYCIN CRITICAL INTERACTION WITH DIGITALIS ERYTHROMYCIN CRITICAL INTERACTION WITH ERGOT ERYTHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE ERYTHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE ERYTHROMYCIN CRITICAL INTERACTION WITH TERFENADINE ERYTHROMYCIN CRITICAL INTERACTION WITH THEOPHYLLINE ERYTHROMYCIN CRITICAL INTERACTION WITH VINBLASTINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH ALFENTANIL ERYTHROMYCIN SIGNIFICANT INTERACTION WITH ANISINDIONE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH BROMOCRIPTINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH CARBAMAZEPINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH CLOZAPINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH DICUMAROL ERYTHROMYCIN SIGNIFICANT INTERACTION WITH MIDAZOLAM ERYTHROMYCIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON ERYTHROMYCIN SIGNIFICANT INTERACTION WITH TACROLIMUS ERYTHROMYCIN SIGNIFICANT INTERACTION WITH TRIAZOLAM ERYTHROMYCIN SIGNIFICANT INTERACTION WITH WARFARIN ESMOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ESTAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE ESTAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH AMIKACIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH BENAZEPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH DIGITALIS ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH FOSINOPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH GENTAMICIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH KANAMYCIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH NETILMICIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH QUINAPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH RAMIPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH STREPTOMYCIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH TOBRAMYCIN ETHINYL ESTRADIOL CRITICAL INTERACTION WITH CARBAMAZEPINE ETHINYL ESTRADIOL SIGNIFICANT INTERACTION WITH RIFABUTIN ETHINYL ESTRADIOL SIGNIFICANT INTERACTION WITH RIFAMPIN ETHOTOIN CRITICAL INTERACTION WITH CYCLOSPORINE ETHOTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE

128 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

ETHOTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE ETHYNODIOL DIACETATE CRITICAL INTERACTION WITH CARBAMAZEPINE ETHYNODIOL DIACETATE SIGNIFICANT INTERACTION WITH RIFABUTIN ETHYNODIOL DIACETATE SIGNIFICANT INTERACTION WITH RIFAMPIN ETODOLAC SIGNIFICANT INTERACTION WITH ANISINDIONE ETODOLAC SIGNIFICANT INTERACTION WITH DICUMAROL ETODOLAC SIGNIFICANT INTERACTION WITH METHOTREXATE ETODOLAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON ETODOLAC SIGNIFICANT INTERACTION WITH WARFARIN ETOPOSIDE CRITICAL INTERACTION WITH CYCLOSPORINE FAMOTIDINE SIGNIFICANT INTERACTION WITH ENOXACIN FELBAMATE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE FELBAMATE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FELBAMATE SIGNIFICANT INTERACTION WITH PHENYTOIN FELODIPINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL FELODIPINE SIGNIFICANT INTERACTION WITH ATENOLOL FELODIPINE SIGNIFICANT INTERACTION WITH BETAXOLOL FELODIPINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE FELODIPINE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE FELODIPINE SIGNIFICANT INTERACTION WITH CARTEOLOL FELODIPINE SIGNIFICANT INTERACTION WITH ESMOLOL FELODIPINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FELODIPINE SIGNIFICANT INTERACTION WITH LABETALOL FELODIPINE SIGNIFICANT INTERACTION WITH METOPROLOL FELODIPINE SIGNIFICANT INTERACTION WITH NADOLOL FELODIPINE SIGNIFICANT INTERACTION WITH PENBUTOLOL FELODIPINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL FELODIPINE SIGNIFICANT INTERACTION WITH PHENYTOIN FELODIPINE SIGNIFICANT INTERACTION WITH PINDOLOL FELODIPINE SIGNIFICANT INTERACTION WITH PROPRANOLOL FELODIPINE SIGNIFICANT INTERACTION WITH SOTALOL FELODIPINE SIGNIFICANT INTERACTION WITH TIMOLOL FENFLURAMINE CRITICAL INTERACTION WITH ERGOT FENFLURAMINE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE FENFLURAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID FENFLURAMINE CRITICAL INTERACTION WITH PARGYLINE FENFLURAMINE CRITICAL INTERACTION WITH PHENELZINE FENFLURAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE

April 1998 National Drug File V. 3.18 129 User Manual Appendix D

FENFLURAMINE SIGNIFICANT INTERACTION WITH SELEGILINE FENOPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE FENOPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL FENOPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE FENOPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON FENOPROFEN SIGNIFICANT INTERACTION WITH WARFARIN FENTANYL CRITICAL INTERACTION WITH AMIODARONE FERROUS FUMARATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS FUMARATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS FUMARATE SIGNIFICANT INTERACTION WITH OFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH OFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH OFLOXACIN FLUCONAZOLE CRITICAL INTERACTION WITH ANISINDIONE FLUCONAZOLE CRITICAL INTERACTION WITH CISAPRIDE FLUCONAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE FLUCONAZOLE CRITICAL INTERACTION WITH DICUMAROL FLUCONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON FLUCONAZOLE CRITICAL INTERACTION WITH RIFABUTIN FLUCONAZOLE CRITICAL INTERACTION WITH RIFAMPIN FLUCONAZOLE CRITICAL INTERACTION WITH TACROLIMUS FLUCONAZOLE CRITICAL INTERACTION WITH WARFARIN FLUCONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM FLUDROCORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH RIFABUTIN FLUDROCORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN FLUOXETINE CRITICAL INTERACTION WITH ISOCARBOXAZID FLUOXETINE CRITICAL INTERACTION WITH PARGYLINE FLUOXETINE CRITICAL INTERACTION WITH PHENELZINE FLUOXETINE CRITICAL INTERACTION WITH SELEGILINE FLUOXETINE CRITICAL INTERACTION WITH TRANYLCYPROMINE FLUOXETINE SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FLUOXETINE SIGNIFICANT INTERACTION WITH AMITRIPTYLINE

130 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

FLUOXETINE SIGNIFICANT INTERACTION WITH AMOXAPINE FLUOXETINE SIGNIFICANT INTERACTION WITH CLOMIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH CYPROHEPTADINE FLUOXETINE SIGNIFICANT INTERACTION WITH DESIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH DOXEPIN FLUOXETINE SIGNIFICANT INTERACTION WITH ETHOTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FLUOXETINE SIGNIFICANT INTERACTION WITH IMIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH MEPHENYTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH NORTRIPTYLINE FLUOXETINE SIGNIFICANT INTERACTION WITH PHENYTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH PROTRIPTYLINE FLUOXETINE SIGNIFICANT INTERACTION WITH THEOPHYLLINE FLUOXETINE SIGNIFICANT INTERACTION WITH TRIMIPRAMINE FLUOXYMESTERONE SIGNIFICANT INTERACTION WITH WARFARIN FLURAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE FLURAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR FLURBIPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE FLURBIPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL FLURBIPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE FLURBIPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON FLURBIPROFEN SIGNIFICANT INTERACTION WITH WARFARIN FLUVASTATIN SODIUM SIGNIFICANT INTERACTION WITH GEMFIBROZIL FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH ASTEMIZOLE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH ISOCARBOXAZID FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH PARGYLINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH PHENELZINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH SELEGILINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH TERFENADINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH TRANYLCYPROMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMITRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMOXAPINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH CLOMIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH CLOZAPINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH DESIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH DOXEPIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH ETHOTOIN

April 1998 National Drug File V. 3.18 131 User Manual Appendix D

FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH IMIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH MEPHENYTOIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH NORTRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH PHENYTOIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH PROTRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH THEOPHYLLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH TRIMIPRAMINE FOSCARNET CRITICAL INTERACTION WITH CYCLOSPORINE FOSCARNET SIGNIFICANT INTERACTION WITH PENTAMIDINE FOSINOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID FOSINOPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN FOSINOPRIL SIGNIFICANT INTERACTION WITH LITHIUM FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE FOSINOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE FOSINOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH CIMETIDINE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH CYCLOSPORINE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH ISONIAZID FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH CHLORAMPHENICOL FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DISULFIRAM FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DOXYCYCLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FELBAMATE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FELODIPINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FLUOXETINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH ITRACONAZOLE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON

132 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH TENIPOSIDE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH THEOPHYLLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH TICLOPIDINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH WARFARIN FUROSEMIDE SIGNIFICANT INTERACTION WITH AMIKACIN FUROSEMIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH DIGITALIS FUROSEMIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH GENTAMICIN FUROSEMIDE SIGNIFICANT INTERACTION WITH KANAMYCIN FUROSEMIDE SIGNIFICANT INTERACTION WITH NETILMICIN FUROSEMIDE SIGNIFICANT INTERACTION WITH QUINAPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH RAMIPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN FUROSEMIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH AMIKACIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH GENTAMICIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH KANAMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH NEOMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH NETILMICIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN GANCICLOVIR CRITICAL INTERACTION WITH ZIDOVUDINE GANCICLOVIR SIGNIFICANT INTERACTION WITH DIDANOSINE GEMFIBROZIL CRITICAL INTERACTION WITH LOVASTATIN GEMFIBROZIL SIGNIFICANT INTERACTION WITH FLUVASTATIN SODIUM GEMFIBROZIL SIGNIFICANT INTERACTION WITH PRAVASTATIN GEMFIBROZIL SIGNIFICANT INTERACTION WITH SIMVASTATIN GENTAMICIN SIGNIFICANT INTERACTION WITH AMPICILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH ATRACURIUM GENTAMICIN SIGNIFICANT INTERACTION WITH BUMETANIDE GENTAMICIN SIGNIFICANT INTERACTION WITH CARBENICILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID GENTAMICIN SIGNIFICANT INTERACTION WITH FUROSEMIDE GENTAMICIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE GENTAMICIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE GENTAMICIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH PANCURONIUM

April 1998 National Drug File V. 3.18 133 User Manual Appendix D

GENTAMICIN SIGNIFICANT INTERACTION WITH PIPERACILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH TICARCILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH TORSEMIDE GENTAMICIN SIGNIFICANT INTERACTION WITH TUBOCURARINE GENTAMICIN SIGNIFICANT INTERACTION WITH VANCOMYCIN GENTAMICIN SIGNIFICANT INTERACTION WITH VECURONIUM GLIPIZIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH ATENOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH BETAXOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE GLIPIZIDE SIGNIFICANT INTERACTION WITH CARTEOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH LABETALOL GLIPIZIDE SIGNIFICANT INTERACTION WITH METOPROLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH NADOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PINDOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH SOTALOL GLIPIZIDE SIGNIFICANT INTERACTION WITH TIMOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH ATENOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH BETAXOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE GLYBURIDE SIGNIFICANT INTERACTION WITH CARTEOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH LABETALOL GLYBURIDE SIGNIFICANT INTERACTION WITH METOPROLOL GLYBURIDE SIGNIFICANT INTERACTION WITH NADOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PINDOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH SOTALOL GLYBURIDE SIGNIFICANT INTERACTION WITH TIMOLOL HALAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE HALAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR HALOPERIDOL SIGNIFICANT INTERACTION WITH LITHIUM HALOPERIDOL SIGNIFICANT INTERACTION WITH RIFAMPIN HALOPERIDOL SIGNIFICANT INTERACTION WITH TACRINE HYDROCHLORIDE HALOTHANE SIGNIFICANT INTERACTION WITH LABETALOL

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HEPARIN SIGNIFICANT INTERACTION WITH ASPIRIN HEPARIN SIGNIFICANT INTERACTION WITH BISMUTH SUBSALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH CHOLINE SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH MAGNESIUM SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH SALSALATE HEPARIN SIGNIFICANT INTERACTION WITH SODIUM SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH SODIUM THIOSALICYLATE HYDROCHLOROTHIAZIDE CRITICAL INTERACTION WITH LITHIUM HYDROCHLOROTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS HYDROCORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE HYDROCORTISONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE HYDROCORTISONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE HYDROCORTISONE SIGNIFICANT INTERACTION WITH RIFABUTIN HYDROCORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN HYDROFLUMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM HYDROFLUMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS IBUPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE IBUPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL IBUPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE IBUPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON IBUPROFEN SIGNIFICANT INTERACTION WITH WARFARIN IMIPENEM SIGNIFICANT INTERACTION WITH CYCLOSPORINE IMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE IMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID IMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE IMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE IMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE IMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE IMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE IMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE INDAPAMIDE CRITICAL INTERACTION WITH LITHIUM INDAPAMIDE SIGNIFICANT INTERACTION WITH DIGITALIS INDINAVIR SULFATE CRITICAL INTERACTION WITH ASTEMIZOLE INDINAVIR SULFATE CRITICAL INTERACTION WITH CISAPRIDE INDINAVIR SULFATE CRITICAL INTERACTION WITH TERFENADINE INDINAVIR SULFATE SIGNIFICANT INTERACTION WITH MIDAZOLAM INDINAVIR SULFATE SIGNIFICANT INTERACTION WITH TRIAZOLAM INDOMETHACIN SIGNIFICANT INTERACTION WITH ACEBUTOLOL

April 1998 National Drug File V. 3.18 135 User Manual Appendix D

INDOMETHACIN SIGNIFICANT INTERACTION WITH ANISINDIONE INDOMETHACIN SIGNIFICANT INTERACTION WITH ATENOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH BENAZEPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH BETAXOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE INDOMETHACIN SIGNIFICANT INTERACTION WITH CAPTOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH CARTEOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH DICUMAROL INDOMETHACIN SIGNIFICANT INTERACTION WITH ENALAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH FOSINOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH LABETALOL INDOMETHACIN SIGNIFICANT INTERACTION WITH LISINOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH METHOTREXATE INDOMETHACIN SIGNIFICANT INTERACTION WITH METOPROLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH NADOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PENBUTOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON INDOMETHACIN SIGNIFICANT INTERACTION WITH PINDOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PROPRANOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH QUINAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH RAMIPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH SOTALOL INDOMETHACIN SIGNIFICANT INTERACTION WITH TIMOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH TRANDOLAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH WARFARIN INSULIN SIGNIFICANT INTERACTION WITH ACEBUTOLOL INSULIN SIGNIFICANT INTERACTION WITH ATENOLOL INSULIN SIGNIFICANT INTERACTION WITH BETAXOLOL INSULIN SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE INSULIN SIGNIFICANT INTERACTION WITH CARTEOLOL INSULIN SIGNIFICANT INTERACTION WITH LABETALOL INSULIN SIGNIFICANT INTERACTION WITH METOPROLOL INSULIN SIGNIFICANT INTERACTION WITH NADOLOL INSULIN SIGNIFICANT INTERACTION WITH PENBUTOLOL INSULIN SIGNIFICANT INTERACTION WITH PINDOLOL INSULIN SIGNIFICANT INTERACTION WITH PROPRANOLOL INSULIN SIGNIFICANT INTERACTION WITH SOTALOL INSULIN SIGNIFICANT INTERACTION WITH TIMOLOL

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IRON SIGNIFICANT INTERACTION WITH CIPROFLOXACIN IRON SIGNIFICANT INTERACTION WITH LOMEFLOXACIN IRON SIGNIFICANT INTERACTION WITH NORFLOXACIN IRON SIGNIFICANT INTERACTION WITH OFLOXACIN ISOCARBOXAZID CRITICAL INTERACTION WITH AMITRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH AMOXAPINE ISOCARBOXAZID CRITICAL INTERACTION WITH AMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH BENZPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH CLOMIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DESIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DEXTROAMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DEXTROMETHORPHAN ISOCARBOXAZID CRITICAL INTERACTION WITH DIETHYLPROPION ISOCARBOXAZID CRITICAL INTERACTION WITH DOPAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DOXEPIN ISOCARBOXAZID CRITICAL INTERACTION WITH EPHEDRINE ISOCARBOXAZID CRITICAL INTERACTION WITH FENFLURAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH FLUOXETINE ISOCARBOXAZID CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE ISOCARBOXAZID CRITICAL INTERACTION WITH IMIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH MEPERIDINE ISOCARBOXAZID CRITICAL INTERACTION WITH METHAMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH NORTRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH PAROXETINE ISOCARBOXAZID CRITICAL INTERACTION WITH PHENYLEPHRINE ISOCARBOXAZID CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH PROTRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH PSEUDOEPHEDRINE ISOCARBOXAZID CRITICAL INTERACTION WITH SERTRALINE ISOCARBOXAZID CRITICAL INTERACTION WITH TRIMIPRAMINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH MAZINDOL ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENDIMETRAZINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENMETRAZINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENTERMINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH SUMATRIPTAN ISOCARBOXAZID SIGNIFICANT INTERACTION WITH SUMATRIPTAN SUCCINATE

April 1998 National Drug File V. 3.18 137 User Manual Appendix D

ISOCARBOXAZID SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE ISOFLURANE SIGNIFICANT INTERACTION WITH LABETALOL ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH BROMOCRIPTINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH PARGYLINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH PHENELZINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE ISONIAZID CRITICAL INTERACTION WITH CARBAMAZEPINE ISONIAZID CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM ISONIAZID CRITICAL INTERACTION WITH PHENYTOIN ISONIAZID SIGNIFICANT INTERACTION WITH ENFLURANE ITRACONAZOLE CRITICAL INTERACTION WITH ANISINDIONE ITRACONAZOLE CRITICAL INTERACTION WITH ASTEMIZOLE ITRACONAZOLE CRITICAL INTERACTION WITH CISAPRIDE ITRACONAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE ITRACONAZOLE CRITICAL INTERACTION WITH DICUMAROL ITRACONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON ITRACONAZOLE CRITICAL INTERACTION WITH RIFABUTIN ITRACONAZOLE CRITICAL INTERACTION WITH RIFAMPIN ITRACONAZOLE CRITICAL INTERACTION WITH TERFENADINE ITRACONAZOLE CRITICAL INTERACTION WITH WARFARIN ITRACONAZOLE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE ITRACONAZOLE SIGNIFICANT INTERACTION WITH DIDANOSINE ITRACONAZOLE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM ITRACONAZOLE SIGNIFICANT INTERACTION WITH MEPHENYTOIN ITRACONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM ITRACONAZOLE SIGNIFICANT INTERACTION WITH PHENYTOIN ITRACONAZOLE SIGNIFICANT INTERACTION WITH TRIAZOLAM KANAMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE KANAMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID KANAMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE KANAMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE KANAMYCIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE KANAMYCIN SIGNIFICANT INTERACTION WITH PANCURONIUM KANAMYCIN SIGNIFICANT INTERACTION WITH TORSEMIDE KANAMYCIN SIGNIFICANT INTERACTION WITH TUBOCURARINE KANAMYCIN SIGNIFICANT INTERACTION WITH VECURONIUM KETOCONAZOLE CRITICAL INTERACTION WITH ANISINDIONE

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KETOCONAZOLE CRITICAL INTERACTION WITH ASTEMIZOLE KETOCONAZOLE CRITICAL INTERACTION WITH CISAPRIDE KETOCONAZOLE CRITICAL INTERACTION WITH DICUMAROL KETOCONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON KETOCONAZOLE CRITICAL INTERACTION WITH RIFABUTIN KETOCONAZOLE CRITICAL INTERACTION WITH RIFAMPIN KETOCONAZOLE CRITICAL INTERACTION WITH TERFENADINE KETOCONAZOLE CRITICAL INTERACTION WITH WARFARIN KETOCONAZOLE SIGNIFICANT INTERACTION WITH CYCLOSPORINE KETOCONAZOLE SIGNIFICANT INTERACTION WITH DIDANOSINE KETOCONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM KETOCONAZOLE SIGNIFICANT INTERACTION WITH TRIAZOLAM KETOPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE KETOPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL KETOPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE KETOPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON KETOPROFEN SIGNIFICANT INTERACTION WITH WARFARIN KETOROLAC TROMETHAMINE CRITICAL INTERACTION WITH PROBENECID KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH ANISINDIONE KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH DICUMAROL KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH METHOTREXATE KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH WARFARIN LABETALOL CRITICAL INTERACTION WITH VERAPAMIL LABETALOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE LABETALOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE LABETALOL SIGNIFICANT INTERACTION WITH DESFLURANE LABETALOL SIGNIFICANT INTERACTION WITH ENFLURANE LABETALOL SIGNIFICANT INTERACTION WITH EPINEPHRINE LABETALOL SIGNIFICANT INTERACTION WITH FELODIPINE LABETALOL SIGNIFICANT INTERACTION WITH GLIPIZIDE LABETALOL SIGNIFICANT INTERACTION WITH GLYBURIDE LABETALOL SIGNIFICANT INTERACTION WITH HALOTHANE LABETALOL SIGNIFICANT INTERACTION WITH INDOMETHACIN LABETALOL SIGNIFICANT INTERACTION WITH INSULIN LABETALOL SIGNIFICANT INTERACTION WITH ISOFLURANE LABETALOL SIGNIFICANT INTERACTION WITH METHOXYFLURANE LABETALOL SIGNIFICANT INTERACTION WITH PIROXICAM

April 1998 National Drug File V. 3.18 139 User Manual Appendix D

LABETALOL SIGNIFICANT INTERACTION WITH SEVOFLURANE LABETALOL SIGNIFICANT INTERACTION WITH SULINDAC LABETALOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE LABETALOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE LEVAMISOLE SIGNIFICANT INTERACTION WITH ANISINDIONE LEVAMISOLE SIGNIFICANT INTERACTION WITH DICUMAROL LEVAMISOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON LEVAMISOLE SIGNIFICANT INTERACTION WITH WARFARIN LEVODOPA SIGNIFICANT INTERACTION WITH RISPERIDONE LEVONORGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE LEVONORGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN LEVONORGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH SUCRALFATE LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN LISINOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE LISINOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN LISINOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE LISINOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE LITHIUM CRITICAL INTERACTION WITH BENDROFLUMETHIAZIDE LITHIUM CRITICAL INTERACTION WITH BENZTHIAZIDE LITHIUM CRITICAL INTERACTION WITH CHLOROTHIAZIDE LITHIUM CRITICAL INTERACTION WITH CHLORTHALIDONE LITHIUM CRITICAL INTERACTION WITH CYCLOTHIAZIDE LITHIUM CRITICAL INTERACTION WITH HYDROCHLOROTHIAZIDE LITHIUM CRITICAL INTERACTION WITH HYDROFLUMETHIAZIDE LITHIUM CRITICAL INTERACTION WITH INDAPAMIDE LITHIUM CRITICAL INTERACTION WITH METHYCLOTHIAZIDE LITHIUM CRITICAL INTERACTION WITH METOLAZONE LITHIUM CRITICAL INTERACTION WITH POLYTHIAZIDE LITHIUM CRITICAL INTERACTION WITH QUINETHAZONE LITHIUM CRITICAL INTERACTION WITH TRICHLORMETHIAZIDE

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LITHIUM SIGNIFICANT INTERACTION WITH BENAZEPRIL LITHIUM SIGNIFICANT INTERACTION WITH FOSINOPRIL LITHIUM SIGNIFICANT INTERACTION WITH HALOPERIDOL LITHIUM SIGNIFICANT INTERACTION WITH QUINAPRIL LITHIUM SIGNIFICANT INTERACTION WITH RAMIPRIL LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH DIHYDROXYALUMINUM SODIUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH IRON LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE LORAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE LOVASTATIN CRITICAL INTERACTION WITH GEMFIBROZIL LOVASTATIN SIGNIFICANT INTERACTION WITH CYCLOSPORINE MAGALDRATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGALDRATE SIGNIFICANT INTERACTION WITH ENOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH ENOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH ENOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE

April 1998 National Drug File V. 3.18 141 User Manual Appendix D

MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH DICUMAROL MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH WARFARIN MAGNESIUM SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN MAZINDOL SIGNIFICANT INTERACTION WITH ISOCARBOXAZID MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH METHOTREXATE MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH ANISINDIONE MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH DICUMAROL MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH METHOTREXATE MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH PHENPROCOUMON MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH WARFARIN MEDROXYPROGESTERONE CRITICAL INTERACTION WITH CARBAMAZEPINE MEDROXYPROGESTERONE SIGNIFICANT INTERACTION WITH RIFABUTIN MEDROXYPROGESTERONE SIGNIFICANT INTERACTION WITH RIFAMPIN MEFENAMIC ACID SIGNIFICANT INTERACTION WITH ANISINDIONE MEFENAMIC ACID SIGNIFICANT INTERACTION WITH DICUMAROL MEFENAMIC ACID SIGNIFICANT INTERACTION WITH METHOTREXATE MEFENAMIC ACID SIGNIFICANT INTERACTION WITH PHENPROCOUMON MEFENAMIC ACID SIGNIFICANT INTERACTION WITH WARFARIN MEPERIDINE CRITICAL INTERACTION WITH ISOCARBOXAZID MEPERIDINE CRITICAL INTERACTION WITH PARGYLINE MEPERIDINE CRITICAL INTERACTION WITH PHENELZINE MEPERIDINE CRITICAL INTERACTION WITH TRANYLCYPROMINE MEPERIDINE SIGNIFICANT INTERACTION WITH CHLORPROMAZINE MEPERIDINE SIGNIFICANT INTERACTION WITH CLOZAPINE MEPERIDINE SIGNIFICANT INTERACTION WITH RISPERIDONE MEPERIDINE SIGNIFICANT INTERACTION WITH THIORIDAZINE MEPHENYTOIN CRITICAL INTERACTION WITH CYCLOSPORINE MEPHENYTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE MEPHENYTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE MEPHENYTOIN SIGNIFICANT INTERACTION WITH ITRACONAZOLE MEPHOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE MEPHOBARBITAL CRITICAL INTERACTION WITH DICUMAROL

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MEPHOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON MERCAPTOPURINE CRITICAL INTERACTION WITH ALLOPURINOL MESTRANOL CRITICAL INTERACTION WITH CARBAMAZEPINE MESTRANOL SIGNIFICANT INTERACTION WITH RIFABUTIN MESTRANOL SIGNIFICANT INTERACTION WITH RIFAMPIN METHAMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID METHAMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE METHAMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE METHAMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE METHIMAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE METHIMAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL METHIMAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON METHIMAZOLE SIGNIFICANT INTERACTION WITH WARFARIN METHOTREXATE CRITICAL INTERACTION WITH ASPIRIN METHOTREXATE CRITICAL INTERACTION WITH CHOLINE SALICYLATE METHOTREXATE SIGNIFICANT INTERACTION WITH BISMUTH SUBSALICYLATE METHOTREXATE SIGNIFICANT INTERACTION WITH DICLOFENAC METHOTREXATE SIGNIFICANT INTERACTION WITH ETODOLAC METHOTREXATE SIGNIFICANT INTERACTION WITH FENOPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH FLURBIPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH IBUPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH INDOMETHACIN METHOTREXATE SIGNIFICANT INTERACTION WITH KETOPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE METHOTREXATE SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM METHOTREXATE SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID METHOTREXATE SIGNIFICANT INTERACTION WITH MEFENAMIC ACID METHOTREXATE SIGNIFICANT INTERACTION WITH NABUMETONE METHOTREXATE SIGNIFICANT INTERACTION WITH NAPROXEN METHOTREXATE SIGNIFICANT INTERACTION WITH OXAPROZIN METHOTREXATE SIGNIFICANT INTERACTION WITH PHENYLBUTAZONE METHOTREXATE SIGNIFICANT INTERACTION WITH PIROXICAM METHOTREXATE SIGNIFICANT INTERACTION WITH PROBENECID METHOTREXATE SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE METHOTREXATE SIGNIFICANT INTERACTION WITH SULINDAC METHOTREXATE SIGNIFICANT INTERACTION WITH TOLMETIN METHOXYFLURANE SIGNIFICANT INTERACTION WITH LABETALOL METHYCLOTHIAZIDE CRITICAL INTERACTION WITH LITHIUM

April 1998 National Drug File V. 3.18 143 User Manual Appendix D

METHYCLOTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS METHYL SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE METHYL SALICYLATE CRITICAL INTERACTION WITH DICUMAROL METHYL SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON METHYLPREDNISOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE METOCLOPRAMIDE SIGNIFICANT INTERACTION WITH CYCLOSPORINE METOCURINE IODIDE SIGNIFICANT INTERACTION WITH AMIKACIN METOCURINE IODIDE SIGNIFICANT INTERACTION WITH GENTAMICIN METOCURINE IODIDE SIGNIFICANT INTERACTION WITH KANAMYCIN METOLAZONE CRITICAL INTERACTION WITH LITHIUM METOLAZONE SIGNIFICANT INTERACTION WITH DIGITALIS METOPROLOL CRITICAL INTERACTION WITH VERAPAMIL METOPROLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH CIMETIDINE METOPROLOL SIGNIFICANT INTERACTION WITH CLONIDINE METOPROLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE METOPROLOL SIGNIFICANT INTERACTION WITH FELODIPINE METOPROLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE METOPROLOL SIGNIFICANT INTERACTION WITH GLYBURIDE METOPROLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN METOPROLOL SIGNIFICANT INTERACTION WITH INSULIN METOPROLOL SIGNIFICANT INTERACTION WITH PIROXICAM METOPROLOL SIGNIFICANT INTERACTION WITH SULINDAC METOPROLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE METRONIDAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE METRONIDAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL METRONIDAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON METRONIDAZOLE SIGNIFICANT INTERACTION WITH WARFARIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH AMIKACIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH NETILMICIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN MICONAZOLE CRITICAL INTERACTION WITH ANISINDIONE MICONAZOLE CRITICAL INTERACTION WITH CISAPRIDE MICONAZOLE CRITICAL INTERACTION WITH DICUMAROL MICONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON

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MICONAZOLE CRITICAL INTERACTION WITH WARFARIN MIDAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE MIDAZOLAM SIGNIFICANT INTERACTION WITH ERYTHROMYCIN MIDAZOLAM SIGNIFICANT INTERACTION WITH FLUCONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH INDINAVIR SULFATE MIDAZOLAM SIGNIFICANT INTERACTION WITH ITRACONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH KETOCONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) MIDAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR MINOCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN MINOCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS NABUMETONE SIGNIFICANT INTERACTION WITH ANISINDIONE NABUMETONE SIGNIFICANT INTERACTION WITH DICUMAROL NABUMETONE SIGNIFICANT INTERACTION WITH METHOTREXATE NABUMETONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON NABUMETONE SIGNIFICANT INTERACTION WITH WARFARIN NADOLOL CRITICAL INTERACTION WITH VERAPAMIL NADOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE NADOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE NADOLOL SIGNIFICANT INTERACTION WITH CLONIDINE NADOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE NADOLOL SIGNIFICANT INTERACTION WITH FELODIPINE NADOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE NADOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE NADOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN NADOLOL SIGNIFICANT INTERACTION WITH INSULIN NADOLOL SIGNIFICANT INTERACTION WITH PIROXICAM NADOLOL SIGNIFICANT INTERACTION WITH SULINDAC NADOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE NADOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE NAPROXEN SIGNIFICANT INTERACTION WITH ANISINDIONE NAPROXEN SIGNIFICANT INTERACTION WITH DICUMAROL NAPROXEN SIGNIFICANT INTERACTION WITH METHOTREXATE NAPROXEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON NAPROXEN SIGNIFICANT INTERACTION WITH WARFARIN NEFAZODONE CRITICAL INTERACTION WITH ASTEMIZOLE NEFAZODONE CRITICAL INTERACTION WITH CISAPRIDE NEFAZODONE CRITICAL INTERACTION WITH TERFENADINE

April 1998 National Drug File V. 3.18 145 User Manual Appendix D

NEOMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM NEOMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE NEOSTIGMINE SIGNIFICANT INTERACTION WITH BETAMETHASONE NEOSTIGMINE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE NEOSTIGMINE SIGNIFICANT INTERACTION WITH HYDROCORTISONE NETILMICIN SIGNIFICANT INTERACTION WITH AMPICILLIN NETILMICIN SIGNIFICANT INTERACTION WITH ATRACURIUM NETILMICIN SIGNIFICANT INTERACTION WITH BUMETANIDE NETILMICIN SIGNIFICANT INTERACTION WITH CARBENICILLIN NETILMICIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID NETILMICIN SIGNIFICANT INTERACTION WITH FUROSEMIDE NETILMICIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE NETILMICIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN NETILMICIN SIGNIFICANT INTERACTION WITH PIPERACILLIN NETILMICIN SIGNIFICANT INTERACTION WITH TICARCILLIN NETILMICIN SIGNIFICANT INTERACTION WITH VANCOMYCIN NITROGLYCERIN CRITICAL INTERACTION WITH ALTEPLASE NITROGLYCERIN CRITICAL INTERACTION WITH ERGOT NITROGLYCERIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE NIZATIDINE SIGNIFICANT INTERACTION WITH ENOXACIN NORETHINDRONE CRITICAL INTERACTION WITH CARBAMAZEPINE NORETHINDRONE SIGNIFICANT INTERACTION WITH RIFABUTIN NORETHINDRONE SIGNIFICANT INTERACTION WITH RIFAMPIN NORETHYNODREL CRITICAL INTERACTION WITH CARBAMAZEPINE NORETHYNODREL SIGNIFICANT INTERACTION WITH RIFABUTIN NORETHYNODREL SIGNIFICANT INTERACTION WITH RIFAMPIN NORFLOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE NORFLOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE NORFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE NORFLOXACIN SIGNIFICANT INTERACTION WITH IRON NORFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE NORGESTIMATE CRITICAL INTERACTION WITH CARBAMAZEPINE NORGESTIMATE SIGNIFICANT INTERACTION WITH RIFABUTIN NORGESTIMATE SIGNIFICANT INTERACTION WITH RIFAMPIN NORGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE

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NORGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN NORGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN NORTRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE NORTRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID NORTRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE NORTRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE NORTRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE NORTRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE NORTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE NORTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE OFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE OFLOXACIN SIGNIFICANT INTERACTION WITH IRON OFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH AMINOPHYLLINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ASTEMIZOLE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH CISAPRIDE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH CYCLOSPORINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ERGOT OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH TERFENADINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH THEOPHYLLINE OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH CARBAMAZEPINE OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH MIDAZOLAM OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH TRIAZOLAM OXAPROZIN SIGNIFICANT INTERACTION WITH ANISINDIONE OXAPROZIN SIGNIFICANT INTERACTION WITH DICUMAROL OXAPROZIN SIGNIFICANT INTERACTION WITH METHOTREXATE OXAPROZIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON OXAPROZIN SIGNIFICANT INTERACTION WITH WARFARIN OXAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE OXTRIPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE OXTRIPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN OXTRIPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN OXYPHENBUTAZONE CRITICAL INTERACTION WITH ANISINDIONE OXYPHENBUTAZONE CRITICAL INTERACTION WITH DICUMAROL

April 1998 National Drug File V. 3.18 147 User Manual Appendix D

OXYPHENBUTAZONE CRITICAL INTERACTION WITH PHENPROCOUMON OXYTETRACYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN OXYTETRACYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS PANCURONIUM SIGNIFICANT INTERACTION WITH AMIKACIN PANCURONIUM SIGNIFICANT INTERACTION WITH GENTAMICIN PANCURONIUM SIGNIFICANT INTERACTION WITH KANAMYCIN PANCURONIUM SIGNIFICANT INTERACTION WITH TOBRAMYCIN PARAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PARGYLINE CRITICAL INTERACTION WITH AMITRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH AMOXAPINE PARGYLINE CRITICAL INTERACTION WITH AMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH BENZPHETAMINE PARGYLINE CRITICAL INTERACTION WITH CLOMIPRAMINE PARGYLINE CRITICAL INTERACTION WITH DESIPRAMINE PARGYLINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN PARGYLINE CRITICAL INTERACTION WITH DIETHYLPROPION PARGYLINE CRITICAL INTERACTION WITH DOPAMINE PARGYLINE CRITICAL INTERACTION WITH DOXEPIN PARGYLINE CRITICAL INTERACTION WITH EPHEDRINE PARGYLINE CRITICAL INTERACTION WITH FENFLURAMINE PARGYLINE CRITICAL INTERACTION WITH FLUOXETINE PARGYLINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE PARGYLINE CRITICAL INTERACTION WITH IMIPRAMINE PARGYLINE CRITICAL INTERACTION WITH MEPERIDINE PARGYLINE CRITICAL INTERACTION WITH METHAMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH NORTRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH PAROXETINE PARGYLINE CRITICAL INTERACTION WITH PHENYLEPHRINE PARGYLINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE PARGYLINE CRITICAL INTERACTION WITH PROTRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH PSEUDOEPHEDRINE PARGYLINE CRITICAL INTERACTION WITH SERTRALINE PARGYLINE CRITICAL INTERACTION WITH TRIMIPRAMINE PARGYLINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE PARGYLINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE PAROXETINE CRITICAL INTERACTION WITH ISOCARBOXAZID PAROXETINE CRITICAL INTERACTION WITH PARGYLINE

148 National Drug File V. 3.18 April 1998 User Manual Combined Drug Interactions

PAROXETINE CRITICAL INTERACTION WITH PHENELZINE PAROXETINE CRITICAL INTERACTION WITH SELEGILINE PAROXETINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PAROXETINE SIGNIFICANT INTERACTION WITH ANISINDIONE PAROXETINE SIGNIFICANT INTERACTION WITH CIMETIDINE PAROXETINE SIGNIFICANT INTERACTION WITH CYPROHEPTADINE PAROXETINE SIGNIFICANT INTERACTION WITH DEXTROMETHORPHAN PAROXETINE SIGNIFICANT INTERACTION WITH DICUMAROL PAROXETINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON PAROXETINE SIGNIFICANT INTERACTION WITH WARFARIN PENBUTOLOL CRITICAL INTERACTION WITH VERAPAMIL PENBUTOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PENBUTOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PENBUTOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PENBUTOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PENBUTOLOL SIGNIFICANT INTERACTION WITH INSULIN PENBUTOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PENBUTOLOL SIGNIFICANT INTERACTION WITH SULINDAC PENBUTOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PENTAMIDINE SIGNIFICANT INTERACTION WITH FOSCARNET PENTOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE PENTOBARBITAL CRITICAL INTERACTION WITH DICUMAROL PENTOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON PENTOBARBITAL CRITICAL INTERACTION WITH WARFARIN PHENDIMETRAZINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENELZINE CRITICAL INTERACTION WITH AMITRIPTYLINE PHENELZINE CRITICAL INTERACTION WITH AMOXAPINE PHENELZINE CRITICAL INTERACTION WITH AMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH BENZPHETAMINE PHENELZINE CRITICAL INTERACTION WITH CLOMIPRAMINE PHENELZINE CRITICAL INTERACTION WITH DESIPRAMINE PHENELZINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN

April 1998 National Drug File V. 3.18 149 User Manual Appendix D

PHENELZINE CRITICAL INTERACTION WITH DIETHYLPROPION PHENELZINE CRITICAL INTERACTION WITH DOPAMINE PHENELZINE CRITICAL INTERACTION WITH DOXEPIN PHENELZINE CRITICAL INTERACTION WITH EPHEDRINE PHENELZINE CRITICAL INTERACTION WITH FENFLURAMINE PHENELZINE CRITICAL INTERACTION WITH FLUOXETINE PHENELZINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE PHENELZINE CRITICAL INTERACTION WITH IMIPRAMINE PHENELZINE CRITICAL INTERACTION WITH MEPERIDINE PHENELZINE CRITICAL INTERACTION WITH METHAMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH NORTRIPTYLINE PHENELZINE CRITICAL INTERACTION WITH PAROXETINE PHENELZINE CRITICAL INTERACTION WITH PHENYLEPHRINE PHENELZINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE PHENELZINE CRITICAL INTERACTION WITH PROTRIPTYLINE PHENELZINE CRITICAL INTERACTION WITH SERTRALINE PHENELZINE CRITICAL INTERACTION WITH TRIMIPRAMINE PHENELZINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE PHENELZINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE PHENELZINE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE PHENELZINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE PHENMETRAZINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE PHENOBARBITAL CRITICAL INTERACTION WITH DICUMAROL PHENOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON PHENOBARBITAL CRITICAL INTERACTION WITH WARFARIN PHENOBARBITAL SIGNIFICANT INTERACTION WITH AMINOPHYLLINE PHENOBARBITAL SIGNIFICANT INTERACTION WITH FELODIPINE PHENOBARBITAL SIGNIFICANT INTERACTION WITH TENIPOSIDE PHENOBARBITAL SIGNIFICANT INTERACTION WITH THEOPHYLLINE PHENPROCOUMON CRITICAL INTERACTION WITH AMIODARONE PHENPROCOUMON CRITICAL INTERACTION WITH AMOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH ASPIRIN PHENPROCOUMON CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH CARBAMAZEPINE PHENPROCOUMON CRITICAL INTERACTION WITH CHOLINE SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH CIMETIDINE PHENPROCOUMON CRITICAL INTERACTION WITH CLOFIBRATE

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PHENPROCOUMON CRITICAL INTERACTION WITH DANAZOL PHENPROCOUMON CRITICAL INTERACTION WITH DISULFIRAM PHENPROCOUMON CRITICAL INTERACTION WITH FLUCONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH ITRACONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH KETOCONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH MEPHOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH METHYL SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH MICONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH OXYPHENBUTAZONE PHENPROCOUMON CRITICAL INTERACTION WITH PENTOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH PHENOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH PHENYLBUTAZONE PHENPROCOUMON CRITICAL INTERACTION WITH PRIMIDONE PHENPROCOUMON CRITICAL INTERACTION WITH RIFAMPIN PHENPROCOUMON CRITICAL INTERACTION WITH SALSALATE PHENPROCOUMON CRITICAL INTERACTION WITH SECOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH SODIUM SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE PHENPROCOUMON SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH DICLOFENAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH DIFLUNISAL PHENPROCOUMON SIGNIFICANT INTERACTION WITH ERYTHROMYCIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH ETODOLAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH FENOPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH FLURBIPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH IBUPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH INDOMETHACIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH KETOPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH LEVAMISOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID PHENPROCOUMON SIGNIFICANT INTERACTION WITH MEFENAMIC ACID PHENPROCOUMON SIGNIFICANT INTERACTION WITH METHIMAZOLE

April 1998 National Drug File V. 3.18 151 User Manual Appendix D

PHENPROCOUMON SIGNIFICANT INTERACTION WITH METRONIDAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH NABUMETONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH NAPROXEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH OXAPROZIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH PAROXETINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH PHENYTOIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH PHYTONADIONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH PIROXICAM PHENPROCOUMON SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFINPYRAZONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFISOXAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULINDAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH THYROGLOBULIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH THYROID PHENPROCOUMON SIGNIFICANT INTERACTION WITH TOLMETIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH VITAMIN E PHENPROCOUMON SIGNIFICANT INTERACTION WITH VITAMIN K PHENTERMINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENYLBUTAZONE CRITICAL INTERACTION WITH ANISINDIONE PHENYLBUTAZONE CRITICAL INTERACTION WITH DICUMAROL PHENYLBUTAZONE CRITICAL INTERACTION WITH PHENPROCOUMON PHENYLBUTAZONE CRITICAL INTERACTION WITH WARFARIN PHENYLBUTAZONE SIGNIFICANT INTERACTION WITH METHOTREXATE PHENYLEPHRINE CRITICAL INTERACTION WITH ISOCARBOXAZID PHENYLEPHRINE CRITICAL INTERACTION WITH PARGYLINE PHENYLEPHRINE CRITICAL INTERACTION WITH PHENELZINE PHENYLEPHRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH PARGYLINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH PHENELZINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PHENYLPROPANOLAMINE SIGNIFICANT INTERACTION WITH BROMOCRIPTINE PHENYTOIN CRITICAL INTERACTION WITH CIMETIDINE PHENYTOIN CRITICAL INTERACTION WITH CYCLOSPORINE PHENYTOIN CRITICAL INTERACTION WITH ISONIAZID PHENYTOIN SIGNIFICANT INTERACTION WITH AMINOPHYLLINE PHENYTOIN SIGNIFICANT INTERACTION WITH ANISINDIONE

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PHENYTOIN SIGNIFICANT INTERACTION WITH CHLORAMPHENICOL PHENYTOIN SIGNIFICANT INTERACTION WITH DICUMAROL PHENYTOIN SIGNIFICANT INTERACTION WITH DISULFIRAM PHENYTOIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE PHENYTOIN SIGNIFICANT INTERACTION WITH FELBAMATE PHENYTOIN SIGNIFICANT INTERACTION WITH FELODIPINE PHENYTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE PHENYTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE PHENYTOIN SIGNIFICANT INTERACTION WITH ITRACONAZOLE PHENYTOIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON PHENYTOIN SIGNIFICANT INTERACTION WITH TENIPOSIDE PHENYTOIN SIGNIFICANT INTERACTION WITH THEOPHYLLINE PHENYTOIN SIGNIFICANT INTERACTION WITH TICLOPIDINE PHENYTOIN SIGNIFICANT INTERACTION WITH WARFARIN PHYTONADIONE SIGNIFICANT INTERACTION WITH ANISINDIONE PHYTONADIONE SIGNIFICANT INTERACTION WITH DICUMAROL PHYTONADIONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON PIMOZIDE CRITICAL INTERACTION WITH AZITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH CLARITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH DIRITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH ERYTHROMYCIN PINDOLOL CRITICAL INTERACTION WITH VERAPAMIL PINDOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PINDOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PINDOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PINDOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PINDOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PINDOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PINDOLOL SIGNIFICANT INTERACTION WITH INSULIN PINDOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PINDOLOL SIGNIFICANT INTERACTION WITH SULINDAC PINDOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PIPERACILLIN SIGNIFICANT INTERACTION WITH AMIKACIN PIPERACILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN PIPERACILLIN SIGNIFICANT INTERACTION WITH NETILMICIN

April 1998 National Drug File V. 3.18 153 User Manual Appendix D

PIPERACILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN PIROXICAM SIGNIFICANT INTERACTION WITH ACEBUTOLOL PIROXICAM SIGNIFICANT INTERACTION WITH ANISINDIONE PIROXICAM SIGNIFICANT INTERACTION WITH ATENOLOL PIROXICAM SIGNIFICANT INTERACTION WITH BETAXOLOL PIROXICAM SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE PIROXICAM SIGNIFICANT INTERACTION WITH CARTEOLOL PIROXICAM SIGNIFICANT INTERACTION WITH DICUMAROL PIROXICAM SIGNIFICANT INTERACTION WITH LABETALOL PIROXICAM SIGNIFICANT INTERACTION WITH METHOTREXATE PIROXICAM SIGNIFICANT INTERACTION WITH METOPROLOL PIROXICAM SIGNIFICANT INTERACTION WITH NADOLOL PIROXICAM SIGNIFICANT INTERACTION WITH PENBUTOLOL PIROXICAM SIGNIFICANT INTERACTION WITH PHENPROCOUMON PIROXICAM SIGNIFICANT INTERACTION WITH PINDOLOL PIROXICAM SIGNIFICANT INTERACTION WITH PROPRANOLOL PIROXICAM SIGNIFICANT INTERACTION WITH SOTALOL PIROXICAM SIGNIFICANT INTERACTION WITH TIMOLOL PIROXICAM SIGNIFICANT INTERACTION WITH WARFARIN POLYTHIAZIDE CRITICAL INTERACTION WITH LITHIUM POLYTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH EPHEDRINE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH AMILORIDE

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POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH EPHEDRINE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM IODIDE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM PHOSPHATE SIGNIFICANT INTERACTION WITH AMILORIDE PRAVASTATIN SIGNIFICANT INTERACTION WITH GEMFIBROZIL PRAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE PRAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR PRAZIQUANTEL SIGNIFICANT INTERACTION WITH CHLOROQUINE PREDNISOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PREDNISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PRIMIDONE CRITICAL INTERACTION WITH ANISINDIONE PRIMIDONE CRITICAL INTERACTION WITH DICUMAROL PRIMIDONE CRITICAL INTERACTION WITH PHENPROCOUMON PRIMIDONE CRITICAL INTERACTION WITH WARFARIN PROBENECID CRITICAL INTERACTION WITH ASPIRIN PROBENECID CRITICAL INTERACTION WITH KETOROLAC TROMETHAMINE PROBENECID SIGNIFICANT INTERACTION WITH DIFLUNISAL PROBENECID SIGNIFICANT INTERACTION WITH METHOTREXATE

April 1998 National Drug File V. 3.18 155 User Manual Appendix D

PROCAINAMIDE SIGNIFICANT INTERACTION WITH TRIMETHOPRIM PROPAFENONE SIGNIFICANT INTERACTION WITH DIGITALIS PROPOXYPHENE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE PROPRANOLOL CRITICAL INTERACTION WITH ERGOT PROPRANOLOL CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE PROPRANOLOL CRITICAL INTERACTION WITH VERAPAMIL PROPRANOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH CIMETIDINE PROPRANOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PROPRANOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PROPRANOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PROPRANOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PROPRANOLOL SIGNIFICANT INTERACTION WITH INSULIN PROPRANOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PROPRANOLOL SIGNIFICANT INTERACTION WITH SULINDAC PROPRANOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH ANISINDIONE PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH DICUMAROL PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH PHENPROCOUMON PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH WARFARIN PROTRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE PROTRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID PROTRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE PROTRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE PROTRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE PROTRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PROTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE PROTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE PSEUDOEPHEDRINE CRITICAL INTERACTION WITH ISOCARBOXAZID PSEUDOEPHEDRINE CRITICAL INTERACTION WITH PARGYLINE PSEUDOEPHEDRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH PHENELZINE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE

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PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM ACETATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM CITRATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM LACTATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH TROMETHAMINE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH BETAMETHASONE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH HYDROCORTISONE QUAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE QUAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR QUINAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE QUINAPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE QUINAPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID QUINAPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE QUINAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN QUINAPRIL SIGNIFICANT INTERACTION WITH LITHIUM QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE QUINAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE QUINAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE QUINETHAZONE CRITICAL INTERACTION WITH LITHIUM QUINETHAZONE SIGNIFICANT INTERACTION WITH DIGITALIS QUINIDINE CRITICAL INTERACTION WITH AMIODARONE QUINIDINE SIGNIFICANT INTERACTION WITH AMILORIDE QUINIDINE SIGNIFICANT INTERACTION WITH DIGITALIS QUINIDINE SIGNIFICANT INTERACTION WITH RIFABUTIN QUINIDINE SIGNIFICANT INTERACTION WITH RIFAMPIN QUININE CRITICAL INTERACTION WITH ASTEMIZOLE QUININE CRITICAL INTERACTION WITH TERFENADINE RAMIPRIL SIGNIFICANT INTERACTION WITH AMILORIDE RAMIPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE RAMIPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID RAMIPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE RAMIPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN RAMIPRIL SIGNIFICANT INTERACTION WITH LITHIUM

April 1998 National Drug File V. 3.18 157 User Manual Appendix D

RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE RAMIPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE RAMIPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE RANITIDINE SIGNIFICANT INTERACTION WITH ENOXACIN RIFABUTIN CRITICAL INTERACTION WITH CYCLOSPORINE RIFABUTIN CRITICAL INTERACTION WITH FLUCONAZOLE RIFABUTIN CRITICAL INTERACTION WITH ITRACONAZOLE RIFABUTIN CRITICAL INTERACTION WITH KETOCONAZOLE RIFABUTIN SIGNIFICANT INTERACTION WITH BETAMETHASONE RIFABUTIN SIGNIFICANT INTERACTION WITH DESOGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH ETHINYL ESTRADIOL RIFABUTIN SIGNIFICANT INTERACTION WITH ETHYNODIOL DIACETATE RIFABUTIN SIGNIFICANT INTERACTION WITH FLUDROCORTISONE RIFABUTIN SIGNIFICANT INTERACTION WITH HYDROCORTISONE RIFABUTIN SIGNIFICANT INTERACTION WITH LEVONORGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH MEDROXYPROGESTERONE RIFABUTIN SIGNIFICANT INTERACTION WITH MESTRANOL RIFABUTIN SIGNIFICANT INTERACTION WITH NORETHINDRONE RIFABUTIN SIGNIFICANT INTERACTION WITH NORETHYNODREL RIFABUTIN SIGNIFICANT INTERACTION WITH NORGESTIMATE RIFABUTIN SIGNIFICANT INTERACTION WITH NORGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH QUINIDINE RIFABUTIN SIGNIFICANT INTERACTION WITH SAQUINAVIR RIFAMPIN CRITICAL INTERACTION WITH ANISINDIONE RIFAMPIN CRITICAL INTERACTION WITH CYCLOSPORINE RIFAMPIN CRITICAL INTERACTION WITH DICUMAROL RIFAMPIN CRITICAL INTERACTION WITH FLUCONAZOLE RIFAMPIN CRITICAL INTERACTION WITH ITRACONAZOLE RIFAMPIN CRITICAL INTERACTION WITH KETOCONAZOLE RIFAMPIN CRITICAL INTERACTION WITH PHENPROCOUMON RIFAMPIN CRITICAL INTERACTION WITH WARFARIN RIFAMPIN SIGNIFICANT INTERACTION WITH AMINOPHYLLINE RIFAMPIN SIGNIFICANT INTERACTION WITH BETAMETHASONE RIFAMPIN SIGNIFICANT INTERACTION WITH CORTISONE

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RIFAMPIN SIGNIFICANT INTERACTION WITH DESOGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH DEXAMETHASONE RIFAMPIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE RIFAMPIN SIGNIFICANT INTERACTION WITH ETHINYL ESTRADIOL RIFAMPIN SIGNIFICANT INTERACTION WITH ETHYNODIOL DIACETATE RIFAMPIN SIGNIFICANT INTERACTION WITH FLUDROCORTISONE RIFAMPIN SIGNIFICANT INTERACTION WITH HALOPERIDOL RIFAMPIN SIGNIFICANT INTERACTION WITH HYDROCORTISONE RIFAMPIN SIGNIFICANT INTERACTION WITH LEVONORGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH MEDROXYPROGESTERONE RIFAMPIN SIGNIFICANT INTERACTION WITH MESTRANOL RIFAMPIN SIGNIFICANT INTERACTION WITH NORETHINDRONE RIFAMPIN SIGNIFICANT INTERACTION WITH NORETHYNODREL RIFAMPIN SIGNIFICANT INTERACTION WITH NORGESTIMATE RIFAMPIN SIGNIFICANT INTERACTION WITH NORGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH QUINIDINE RIFAMPIN SIGNIFICANT INTERACTION WITH SAQUINAVIR RIFAMPIN SIGNIFICANT INTERACTION WITH TACROLIMUS RIFAMPIN SIGNIFICANT INTERACTION WITH THEOPHYLLINE RISPERIDONE SIGNIFICANT INTERACTION WITH LEVODOPA RISPERIDONE SIGNIFICANT INTERACTION WITH MEPERIDINE RITONAVIR CRITICAL INTERACTION WITH ASTEMIZOLE RITONAVIR CRITICAL INTERACTION WITH CISAPRIDE RITONAVIR CRITICAL INTERACTION WITH TERFENADINE RITONAVIR SIGNIFICANT INTERACTION WITH ALPRAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH AMIODARONE RITONAVIR SIGNIFICANT INTERACTION WITH BEPRIDIL RITONAVIR SIGNIFICANT INTERACTION WITH CHLORDIAZEPOXIDE RITONAVIR SIGNIFICANT INTERACTION WITH CLONAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH CLORAZEPATE RITONAVIR SIGNIFICANT INTERACTION WITH CLOZAPINE RITONAVIR SIGNIFICANT INTERACTION WITH DIAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH ENCAINIDE RITONAVIR SIGNIFICANT INTERACTION WITH ESTAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH FLURAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH HALAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH MIDAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH PRAZEPAM

April 1998 National Drug File V. 3.18 159 User Manual Appendix D

RITONAVIR SIGNIFICANT INTERACTION WITH QUAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH TEMAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH TRIAZOLAM SALSALATE CRITICAL INTERACTION WITH ANISINDIONE SALSALATE CRITICAL INTERACTION WITH DICUMAROL SALSALATE CRITICAL INTERACTION WITH PHENPROCOUMON SALSALATE CRITICAL INTERACTION WITH WARFARIN SALSALATE SIGNIFICANT INTERACTION WITH HEPARIN SAQUINAVIR SIGNIFICANT INTERACTION WITH RIFABUTIN SAQUINAVIR SIGNIFICANT INTERACTION WITH RIFAMPIN SECOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE SECOBARBITAL CRITICAL INTERACTION WITH DICUMAROL SECOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON SECOBARBITAL CRITICAL INTERACTION WITH WARFARIN SELEGILINE CRITICAL INTERACTION WITH AMITRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH AMOXAPINE SELEGILINE CRITICAL INTERACTION WITH CLOMIPRAMINE SELEGILINE CRITICAL INTERACTION WITH DESIPRAMINE SELEGILINE CRITICAL INTERACTION WITH DOXEPIN SELEGILINE CRITICAL INTERACTION WITH FLUOXETINE SELEGILINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE SELEGILINE CRITICAL INTERACTION WITH IMIPRAMINE SELEGILINE CRITICAL INTERACTION WITH NORTRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH PAROXETINE SELEGILINE CRITICAL INTERACTION WITH PROTRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH SERTRALINE SELEGILINE CRITICAL INTERACTION WITH TRIMIPRAMINE SELEGILINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE SELEGILINE SIGNIFICANT INTERACTION WITH FENFLURAMINE SELEGILINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE SERTRALINE CRITICAL INTERACTION WITH ISOCARBOXAZID SERTRALINE CRITICAL INTERACTION WITH PARGYLINE SERTRALINE CRITICAL INTERACTION WITH PHENELZINE SERTRALINE CRITICAL INTERACTION WITH SELEGILINE SERTRALINE CRITICAL INTERACTION WITH TRANYLCYPROMINE SEVOFLURANE SIGNIFICANT INTERACTION WITH LABETALOL SIMVASTATIN SIGNIFICANT INTERACTION WITH GEMFIBROZIL SODIUM ACETATE SIGNIFICANT INTERACTION WITH EPHEDRINE

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SODIUM ACETATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE SODIUM CITRATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM CITRATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM LACTATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM LACTATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE SODIUM SALICYLATE CRITICAL INTERACTION WITH DICUMAROL SODIUM SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON SODIUM SALICYLATE CRITICAL INTERACTION WITH WARFARIN SODIUM SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH ANISINDIONE SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH DICUMAROL SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH WARFARIN SODIUM THIOSALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN SOTALOL CRITICAL INTERACTION WITH VERAPAMIL SOTALOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE SOTALOL SIGNIFICANT INTERACTION WITH ASTEMIZOLE SOTALOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE SOTALOL SIGNIFICANT INTERACTION WITH EPINEPHRINE SOTALOL SIGNIFICANT INTERACTION WITH FELODIPINE SOTALOL SIGNIFICANT INTERACTION WITH GLIPIZIDE SOTALOL SIGNIFICANT INTERACTION WITH GLYBURIDE SOTALOL SIGNIFICANT INTERACTION WITH INDOMETHACIN SOTALOL SIGNIFICANT INTERACTION WITH INSULIN SOTALOL SIGNIFICANT INTERACTION WITH PIROXICAM SOTALOL SIGNIFICANT INTERACTION WITH SULINDAC SOTALOL SIGNIFICANT INTERACTION WITH TERFENADINE SOTALOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE SOTALOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE SPARFLOXACIN CRITICAL INTERACTION WITH AMIODARONE SPARFLOXACIN CRITICAL INTERACTION WITH DISOPYRAMIDE

April 1998 National Drug File V. 3.18 161 User Manual Appendix D

SPIRONOLACTONE SIGNIFICANT INTERACTION WITH BENAZEPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH CAPTOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH ENALAPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH FOSINOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH LISINOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH QUINAPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH RAMIPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL STREPTOMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM STREPTOMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE STREPTOMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID STREPTOMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE STREPTOMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE SUCRALFATE SIGNIFICANT INTERACTION WITH ENOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM SUCRALFATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH NORFLOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH OFLOXACIN SULFACYTINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFADIAZINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFAMETHIZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SULFAMETHOXAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH METHOTREXATE SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH WARFARIN SULFASALAZINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFINPYRAZONE SIGNIFICANT INTERACTION WITH ACETAMINOPHEN SULFINPYRAZONE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFINPYRAZONE SIGNIFICANT INTERACTION WITH DICUMAROL SULFINPYRAZONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFINPYRAZONE SIGNIFICANT INTERACTION WITH WARFARIN

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SULFISOXAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SULFISOXAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFISOXAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL SULFISOXAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFISOXAZOLE SIGNIFICANT INTERACTION WITH WARFARIN SULINDAC SIGNIFICANT INTERACTION WITH ACEBUTOLOL SULINDAC SIGNIFICANT INTERACTION WITH ANISINDIONE SULINDAC SIGNIFICANT INTERACTION WITH ATENOLOL SULINDAC SIGNIFICANT INTERACTION WITH BETAXOLOL SULINDAC SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE SULINDAC SIGNIFICANT INTERACTION WITH CARTEOLOL SULINDAC SIGNIFICANT INTERACTION WITH DICUMAROL SULINDAC SIGNIFICANT INTERACTION WITH LABETALOL SULINDAC SIGNIFICANT INTERACTION WITH METHOTREXATE SULINDAC SIGNIFICANT INTERACTION WITH METOPROLOL SULINDAC SIGNIFICANT INTERACTION WITH NADOLOL SULINDAC SIGNIFICANT INTERACTION WITH PENBUTOLOL SULINDAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULINDAC SIGNIFICANT INTERACTION WITH PINDOLOL SULINDAC SIGNIFICANT INTERACTION WITH PROPRANOLOL SULINDAC SIGNIFICANT INTERACTION WITH SOTALOL SULINDAC SIGNIFICANT INTERACTION WITH TIMOLOL SULINDAC SIGNIFICANT INTERACTION WITH WARFARIN SUMATRIPTAN CRITICAL INTERACTION WITH ERGOT SUMATRIPTAN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE SUMATRIPTAN SIGNIFICANT INTERACTION WITH ISOCARBOXAZID SUMATRIPTAN SUCCINATE CRITICAL INTERACTION WITH ERGOT SUMATRIPTAN SUCCINATE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE SUMATRIPTAN SUCCINATE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID TACRINE HYDROCHLORIDE CRITICAL INTERACTION WITH THEOPHYLLINE TACRINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH CIMETIDINE TACRINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH HALOPERIDOL TACROLIMUS CRITICAL INTERACTION WITH ERGOT TACROLIMUS CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE TACROLIMUS CRITICAL INTERACTION WITH FLUCONAZOLE TACROLIMUS SIGNIFICANT INTERACTION WITH CLARITHROMYCIN TACROLIMUS SIGNIFICANT INTERACTION WITH CYCLOSPORINE TACROLIMUS SIGNIFICANT INTERACTION WITH DANAZOL

April 1998 National Drug File V. 3.18 163 User Manual Appendix D

TACROLIMUS SIGNIFICANT INTERACTION WITH ERYTHROMYCIN TACROLIMUS SIGNIFICANT INTERACTION WITH RIFAMPIN TEMAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE TEMAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR TENIPOSIDE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM TENIPOSIDE SIGNIFICANT INTERACTION WITH PHENOBARBITAL TENIPOSIDE SIGNIFICANT INTERACTION WITH PHENYTOIN TERFENADINE CRITICAL INTERACTION WITH AZITHROMYCIN TERFENADINE CRITICAL INTERACTION WITH CLARITHROMYCIN TERFENADINE CRITICAL INTERACTION WITH ERYTHROMYCIN TERFENADINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE TERFENADINE CRITICAL INTERACTION WITH INDINAVIR SULFATE TERFENADINE CRITICAL INTERACTION WITH ITRACONAZOLE TERFENADINE CRITICAL INTERACTION WITH KETOCONAZOLE TERFENADINE CRITICAL INTERACTION WITH NEFAZODONE TERFENADINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) TERFENADINE CRITICAL INTERACTION WITH QUININE TERFENADINE CRITICAL INTERACTION WITH RITONAVIR TERFENADINE SIGNIFICANT INTERACTION WITH SOTALOL TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE TETRACYCLINE SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN TETRACYCLINE SIGNIFICANT INTERACTION WITH DIDANOSINE TETRACYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGALDRATE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE THEOPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE THEOPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN THEOPHYLLINE CRITICAL INTERACTION WITH ENOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH ERYTHROMYCIN THEOPHYLLINE CRITICAL INTERACTION WITH NORFLOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN)

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THEOPHYLLINE CRITICAL INTERACTION WITH TACRINE HYDROCHLORIDE THEOPHYLLINE SIGNIFICANT INTERACTION WITH DILTIAZEM THEOPHYLLINE SIGNIFICANT INTERACTION WITH FLUOXETINE THEOPHYLLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE THEOPHYLLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM THEOPHYLLINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL THEOPHYLLINE SIGNIFICANT INTERACTION WITH PHENYTOIN THEOPHYLLINE SIGNIFICANT INTERACTION WITH RIFAMPIN THEOPHYLLINE SIGNIFICANT INTERACTION WITH TICLOPIDINE THEOPHYLLINE SIGNIFICANT INTERACTION WITH VERAPAMIL THIORIDAZINE SIGNIFICANT INTERACTION WITH MEPERIDINE THYROGLOBULIN SIGNIFICANT INTERACTION WITH ANISINDIONE THYROGLOBULIN SIGNIFICANT INTERACTION WITH DICUMAROL THYROGLOBULIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON THYROGLOBULIN SIGNIFICANT INTERACTION WITH WARFARIN THYROID SIGNIFICANT INTERACTION WITH ANISINDIONE THYROID SIGNIFICANT INTERACTION WITH DICUMAROL THYROID SIGNIFICANT INTERACTION WITH PHENPROCOUMON THYROID SIGNIFICANT INTERACTION WITH WARFARIN THYROID SIGNIFICANT INTERACTION WITH WARFARIN TICARCILLIN SIGNIFICANT INTERACTION WITH AMIKACIN TICARCILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN TICARCILLIN SIGNIFICANT INTERACTION WITH NETILMICIN TICARCILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN TICLOPIDINE SIGNIFICANT INTERACTION WITH CYCLOSPORINE TICLOPIDINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM TICLOPIDINE SIGNIFICANT INTERACTION WITH PHENYTOIN TICLOPIDINE SIGNIFICANT INTERACTION WITH THEOPHYLLINE TIMOLOL CRITICAL INTERACTION WITH VERAPAMIL TIMOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH CLONIDINE TIMOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE TIMOLOL SIGNIFICANT INTERACTION WITH FELODIPINE TIMOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE TIMOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE TIMOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN TIMOLOL SIGNIFICANT INTERACTION WITH INSULIN

April 1998 National Drug File V. 3.18 165 User Manual Appendix D

TIMOLOL SIGNIFICANT INTERACTION WITH PIROXICAM TIMOLOL SIGNIFICANT INTERACTION WITH SULINDAC TIMOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH AMPICILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM TOBRAMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH CARBENICILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID TOBRAMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH PANCURONIUM TOBRAMYCIN SIGNIFICANT INTERACTION WITH PIPERACILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH TICARCILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH TUBOCURARINE TOBRAMYCIN SIGNIFICANT INTERACTION WITH VANCOMYCIN TOLAZAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE TOLAZAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH LABETALOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH NADOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH SOTALOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE TOLBUTAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH LABETALOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH NADOLOL

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TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH SOTALOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL TOLMETIN SIGNIFICANT INTERACTION WITH ANISINDIONE TOLMETIN SIGNIFICANT INTERACTION WITH DICUMAROL TOLMETIN SIGNIFICANT INTERACTION WITH METHOTREXATE TOLMETIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON TOLMETIN SIGNIFICANT INTERACTION WITH WARFARIN TORSEMIDE SIGNIFICANT INTERACTION WITH AMIKACIN TORSEMIDE SIGNIFICANT INTERACTION WITH GENTAMICIN TORSEMIDE SIGNIFICANT INTERACTION WITH KANAMYCIN TRANDOLAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE TRANDOLAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN TRANDOLAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE TRANDOLAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE TRANYLCYPROMINE CRITICAL INTERACTION WITH AMITRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH AMOXAPINE TRANYLCYPROMINE CRITICAL INTERACTION WITH AMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH BENZPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH CLOMIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DESIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN TRANYLCYPROMINE CRITICAL INTERACTION WITH DIETHYLPROPION TRANYLCYPROMINE CRITICAL INTERACTION WITH DOPAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DOXEPIN TRANYLCYPROMINE CRITICAL INTERACTION WITH EPHEDRINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FENFLURAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FLUOXETINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE TRANYLCYPROMINE CRITICAL INTERACTION WITH IMIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH MEPERIDINE TRANYLCYPROMINE CRITICAL INTERACTION WITH METHAMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH NORTRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PAROXETINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PHENYLEPHRINE

April 1998 National Drug File V. 3.18 167 User Manual Appendix D

TRANYLCYPROMINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PROTRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PSEUDOEPHEDRINE TRANYLCYPROMINE CRITICAL INTERACTION WITH SERTRALINE TRANYLCYPROMINE CRITICAL INTERACTION WITH TRIMIPRAMINE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE TRIAMCINOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE TRIAMTERENE SIGNIFICANT INTERACTION WITH BENAZEPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH CAPTOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH ENALAPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH FOSINOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH LISINOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE TRIAMTERENE SIGNIFICANT INTERACTION WITH QUINAPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH RAMIPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL TRIAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE TRIAZOLAM SIGNIFICANT INTERACTION WITH ERYTHROMYCIN TRIAZOLAM SIGNIFICANT INTERACTION WITH INDINAVIR SULFATE TRIAZOLAM SIGNIFICANT INTERACTION WITH ITRACONAZOLE TRIAZOLAM SIGNIFICANT INTERACTION WITH KETOCONAZOLE TRIAZOLAM SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) TRIAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR TRICHLORMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM TRICHLORMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS TRIMETHOPRIM SIGNIFICANT INTERACTION WITH CYCLOSPORINE TRIMETHOPRIM SIGNIFICANT INTERACTION WITH PROCAINAMIDE TRIMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE TRIMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID TRIMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE TRIMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE TRIMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE

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TRIMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE TRIMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE TRIMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE TROMETHAMINE SIGNIFICANT INTERACTION WITH EPHEDRINE TROMETHAMINE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE TUBOCURARINE SIGNIFICANT INTERACTION WITH AMIKACIN TUBOCURARINE SIGNIFICANT INTERACTION WITH GENTAMICIN TUBOCURARINE SIGNIFICANT INTERACTION WITH KANAMYCIN TUBOCURARINE SIGNIFICANT INTERACTION WITH TOBRAMYCIN VANCOMYCIN SIGNIFICANT INTERACTION WITH AMIKACIN VANCOMYCIN SIGNIFICANT INTERACTION WITH GENTAMICIN VANCOMYCIN SIGNIFICANT INTERACTION WITH NETILMICIN VANCOMYCIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN VECURONIUM SIGNIFICANT INTERACTION WITH AMIKACIN VECURONIUM SIGNIFICANT INTERACTION WITH GENTAMICIN VECURONIUM SIGNIFICANT INTERACTION WITH KANAMYCIN VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH CIMETIDINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PARGYLINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PHENELZINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH SELEGILINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE VERAPAMIL CRITICAL INTERACTION WITH ACEBUTOLOL VERAPAMIL CRITICAL INTERACTION WITH ATENOLOL VERAPAMIL CRITICAL INTERACTION WITH BETAXOLOL VERAPAMIL CRITICAL INTERACTION WITH BISOPROLOL FUMARATE VERAPAMIL CRITICAL INTERACTION WITH CARTEOLOL VERAPAMIL CRITICAL INTERACTION WITH CYCLOSPORINE VERAPAMIL CRITICAL INTERACTION WITH DIGITALIS VERAPAMIL CRITICAL INTERACTION WITH LABETALOL VERAPAMIL CRITICAL INTERACTION WITH METOPROLOL VERAPAMIL CRITICAL INTERACTION WITH NADOLOL VERAPAMIL CRITICAL INTERACTION WITH PENBUTOLOL VERAPAMIL CRITICAL INTERACTION WITH PINDOLOL VERAPAMIL CRITICAL INTERACTION WITH PROPRANOLOL VERAPAMIL CRITICAL INTERACTION WITH SOTALOL VERAPAMIL CRITICAL INTERACTION WITH TIMOLOL VERAPAMIL SIGNIFICANT INTERACTION WITH CARBAMAZEPINE

April 1998 National Drug File V. 3.18 169 User Manual Appendix D

VERAPAMIL SIGNIFICANT INTERACTION WITH THEOPHYLLINE VINBLASTINE CRITICAL INTERACTION WITH ERYTHROMYCIN VITAMIN E SIGNIFICANT INTERACTION WITH ANISINDIONE VITAMIN E SIGNIFICANT INTERACTION WITH DICUMAROL VITAMIN E SIGNIFICANT INTERACTION WITH PHENPROCOUMON VITAMIN E SIGNIFICANT INTERACTION WITH WARFARIN VITAMIN K SIGNIFICANT INTERACTION WITH ANISINDIONE VITAMIN K SIGNIFICANT INTERACTION WITH DICUMAROL VITAMIN K SIGNIFICANT INTERACTION WITH PHENPROCOUMON VITAMIN K SIGNIFICANT INTERACTION WITH WARFARIN WARFARIN CRITICAL INTERACTION WITH AMIODARONE WARFARIN CRITICAL INTERACTION WITH AMOBARBITAL WARFARIN CRITICAL INTERACTION WITH ASPIRIN WARFARIN CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE WARFARIN CRITICAL INTERACTION WITH CARBAMAZEPINE WARFARIN CRITICAL INTERACTION WITH CHOLINE SALICYLATE WARFARIN CRITICAL INTERACTION WITH CIMETIDINE WARFARIN CRITICAL INTERACTION WITH CLOFIBRATE WARFARIN CRITICAL INTERACTION WITH DISULFIRAM WARFARIN CRITICAL INTERACTION WITH FLUCONAZOLE WARFARIN CRITICAL INTERACTION WITH ITRACONAZOLE WARFARIN CRITICAL INTERACTION WITH KETOCONAZOLE WARFARIN CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE WARFARIN CRITICAL INTERACTION WITH MICONAZOLE WARFARIN CRITICAL INTERACTION WITH PENTOBARBITAL WARFARIN CRITICAL INTERACTION WITH PHENOBARBITAL WARFARIN CRITICAL INTERACTION WITH PHENYLBUTAZONE WARFARIN CRITICAL INTERACTION WITH PRIMIDONE WARFARIN CRITICAL INTERACTION WITH RIFAMPIN WARFARIN CRITICAL INTERACTION WITH SALSALATE WARFARIN CRITICAL INTERACTION WITH SECOBARBITAL WARFARIN CRITICAL INTERACTION WITH SODIUM SALICYLATE WARFARIN CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE WARFARIN SIGNIFICANT INTERACTION WITH BUTALBITAL WARFARIN SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE WARFARIN SIGNIFICANT INTERACTION WITH DICLOFENAC WARFARIN SIGNIFICANT INTERACTION WITH DIFLUNISAL WARFARIN SIGNIFICANT INTERACTION WITH ERYTHROMYCIN

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WARFARIN SIGNIFICANT INTERACTION WITH ETODOLAC WARFARIN SIGNIFICANT INTERACTION WITH FENOPROFEN WARFARIN SIGNIFICANT INTERACTION WITH FLUOXYMESTERONE WARFARIN SIGNIFICANT INTERACTION WITH FLURBIPROFEN WARFARIN SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM WARFARIN SIGNIFICANT INTERACTION WITH IBUPROFEN WARFARIN SIGNIFICANT INTERACTION WITH INDOMETHACIN WARFARIN SIGNIFICANT INTERACTION WITH KETOPROFEN WARFARIN SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE WARFARIN SIGNIFICANT INTERACTION WITH LEVAMISOLE WARFARIN SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID WARFARIN SIGNIFICANT INTERACTION WITH MEFENAMIC ACID WARFARIN SIGNIFICANT INTERACTION WITH METHIMAZOLE WARFARIN SIGNIFICANT INTERACTION WITH METRONIDAZOLE WARFARIN SIGNIFICANT INTERACTION WITH NABUMETONE WARFARIN SIGNIFICANT INTERACTION WITH NAPROXEN WARFARIN SIGNIFICANT INTERACTION WITH OXAPROZIN WARFARIN SIGNIFICANT INTERACTION WITH PAROXETINE WARFARIN SIGNIFICANT INTERACTION WITH PHENYTOIN WARFARIN SIGNIFICANT INTERACTION WITH PIROXICAM WARFARIN SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL WARFARIN SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE WARFARIN SIGNIFICANT INTERACTION WITH SULFINPYRAZONE WARFARIN SIGNIFICANT INTERACTION WITH SULFISOXAZOLE WARFARIN SIGNIFICANT INTERACTION WITH SULINDAC WARFARIN SIGNIFICANT INTERACTION WITH THYROGLOBULIN WARFARIN SIGNIFICANT INTERACTION WITH THYROID WARFARIN SIGNIFICANT INTERACTION WITH THYROID WARFARIN SIGNIFICANT INTERACTION WITH TOLMETIN WARFARIN SIGNIFICANT INTERACTION WITH VITAMIN E WARFARIN SIGNIFICANT INTERACTION WITH VITAMIN K ZALCITABINE (DIDEOXYCYTIDINE,ddC) SIGNIFICANT INTERACTION WITH DIDANOSINE ZIDOVUDINE CRITICAL INTERACTION WITH GANCICLOVIR ZIDOVUDINE SIGNIFICANT INTERACTION WITH ATOVAQUONE

April 1998 National Drug File V. 3.18 171 User Manual Appendix D

Critical Drug Interactions List

ACEBUTOLOL CRITICAL INTERACTION WITH VERAPAMIL ALLOPURINOL CRITICAL INTERACTION WITH AZATHIOPRINE ALLOPURINOL CRITICAL INTERACTION WITH MERCAPTOPURINE ALTEPLASE CRITICAL INTERACTION WITH NITROGLYCERIN AMINOPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE AMINOPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN AMINOPHYLLINE CRITICAL INTERACTION WITH ENOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH ERYTHROMYCIN AMINOPHYLLINE CRITICAL INTERACTION WITH NORFLOXACIN AMINOPHYLLINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) AMIODARONE CRITICAL INTERACTION WITH ANISINDIONE AMIODARONE CRITICAL INTERACTION WITH CYCLOSPORINE AMIODARONE CRITICAL INTERACTION WITH DICUMAROL AMIODARONE CRITICAL INTERACTION WITH DIGITALIS AMIODARONE CRITICAL INTERACTION WITH FENTANYL AMIODARONE CRITICAL INTERACTION WITH PHENPROCOUMON AMIODARONE CRITICAL INTERACTION WITH QUINIDINE AMIODARONE CRITICAL INTERACTION WITH SPARFLOXACIN AMIODARONE CRITICAL INTERACTION WITH WARFARIN AMITRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE AMITRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMITRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE AMITRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE AMITRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE AMITRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE AMOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE AMOBARBITAL CRITICAL INTERACTION WITH DICUMAROL AMOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON AMOBARBITAL CRITICAL INTERACTION WITH WARFARIN AMOXAPINE CRITICAL INTERACTION WITH CLONIDINE AMOXAPINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMOXAPINE CRITICAL INTERACTION WITH PARGYLINE AMOXAPINE CRITICAL INTERACTION WITH PHENELZINE AMOXAPINE CRITICAL INTERACTION WITH SELEGILINE

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AMOXAPINE CRITICAL INTERACTION WITH TRANYLCYPROMINE AMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID AMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE AMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE AMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE ANISINDIONE CRITICAL INTERACTION WITH AMIODARONE ANISINDIONE CRITICAL INTERACTION WITH AMOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH ASPIRIN ANISINDIONE CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE ANISINDIONE CRITICAL INTERACTION WITH CARBAMAZEPINE ANISINDIONE CRITICAL INTERACTION WITH CHOLINE SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH CIMETIDINE ANISINDIONE CRITICAL INTERACTION WITH CLOFIBRATE ANISINDIONE CRITICAL INTERACTION WITH DANAZOL ANISINDIONE CRITICAL INTERACTION WITH DISULFIRAM ANISINDIONE CRITICAL INTERACTION WITH FLUCONAZOLE ANISINDIONE CRITICAL INTERACTION WITH ITRACONAZOLE ANISINDIONE CRITICAL INTERACTION WITH KETOCONAZOLE ANISINDIONE CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH MEPHOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH MEPHOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH METHYL SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH MICONAZOLE ANISINDIONE CRITICAL INTERACTION WITH OXYPHENBUTAZONE ANISINDIONE CRITICAL INTERACTION WITH PENTOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH PHENOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH PHENYLBUTAZONE ANISINDIONE CRITICAL INTERACTION WITH PRIMIDONE ANISINDIONE CRITICAL INTERACTION WITH RIFAMPIN ANISINDIONE CRITICAL INTERACTION WITH SALSALATE ANISINDIONE CRITICAL INTERACTION WITH SECOBARBITAL ANISINDIONE CRITICAL INTERACTION WITH SODIUM SALICYLATE ANISINDIONE CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE ASPIRIN CRITICAL INTERACTION WITH ANISINDIONE ASPIRIN CRITICAL INTERACTION WITH DICUMAROL ASPIRIN CRITICAL INTERACTION WITH METHOTREXATE ASPIRIN CRITICAL INTERACTION WITH PHENPROCOUMON ASPIRIN CRITICAL INTERACTION WITH PROBENECID

April 1998 National Drug File V. 3.18 173 User Manual Appendix D

ASPIRIN CRITICAL INTERACTION WITH WARFARIN ASTEMIZOLE CRITICAL INTERACTION WITH AZITHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH CLARITHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH ERYTHROMYCIN ASTEMIZOLE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE ASTEMIZOLE CRITICAL INTERACTION WITH INDINAVIR SULFATE ASTEMIZOLE CRITICAL INTERACTION WITH ITRACONAZOLE ASTEMIZOLE CRITICAL INTERACTION WITH KETOCONAZOLE ASTEMIZOLE CRITICAL INTERACTION WITH NEFAZODONE ASTEMIZOLE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ASTEMIZOLE CRITICAL INTERACTION WITH QUININE ASTEMIZOLE CRITICAL INTERACTION WITH RITONAVIR ATENOLOL CRITICAL INTERACTION WITH VERAPAMIL AZATHIOPRINE CRITICAL INTERACTION WITH ALLOPURINOL AZITHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE AZITHROMYCIN CRITICAL INTERACTION WITH ERGOT AZITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE AZITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE AZITHROMYCIN CRITICAL INTERACTION WITH TERFENADINE BENDROFLUMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM BENZPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID BENZPHETAMINE CRITICAL INTERACTION WITH PARGYLINE BENZPHETAMINE CRITICAL INTERACTION WITH PHENELZINE BENZPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE BENZTHIAZIDE CRITICAL INTERACTION WITH LITHIUM BETAXOLOL CRITICAL INTERACTION WITH VERAPAMIL BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH ANISINDIONE BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH DICUMAROL BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON BISMUTH SUBSALICYLATE CRITICAL INTERACTION WITH WARFARIN BISOPROLOL FUMARATE CRITICAL INTERACTION WITH VERAPAMIL CARBAMAZEPINE CRITICAL INTERACTION WITH ANISINDIONE CARBAMAZEPINE CRITICAL INTERACTION WITH CYCLOSPORINE CARBAMAZEPINE CRITICAL INTERACTION WITH DESOGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH DICUMAROL CARBAMAZEPINE CRITICAL INTERACTION WITH ETHINYL ESTRADIOL CARBAMAZEPINE CRITICAL INTERACTION WITH ETHYNODIOL DIACETATE CARBAMAZEPINE CRITICAL INTERACTION WITH ISONIAZID

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CARBAMAZEPINE CRITICAL INTERACTION WITH LEVONORGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH MEDROXYPROGESTERONE CARBAMAZEPINE CRITICAL INTERACTION WITH MESTRANOL CARBAMAZEPINE CRITICAL INTERACTION WITH NORETHINDRONE CARBAMAZEPINE CRITICAL INTERACTION WITH NORETHYNODREL CARBAMAZEPINE CRITICAL INTERACTION WITH NORGESTIMATE CARBAMAZEPINE CRITICAL INTERACTION WITH NORGESTREL CARBAMAZEPINE CRITICAL INTERACTION WITH PHENPROCOUMON CARBAMAZEPINE CRITICAL INTERACTION WITH WARFARIN CARMUSTINE CRITICAL INTERACTION WITH CIMETIDINE CARTEOLOL CRITICAL INTERACTION WITH VERAPAMIL CHLOROTHIAZIDE CRITICAL INTERACTION WITH LITHIUM CHLORTHALIDONE CRITICAL INTERACTION WITH LITHIUM CHOLINE SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE CHOLINE SALICYLATE CRITICAL INTERACTION WITH DICUMAROL CHOLINE SALICYLATE CRITICAL INTERACTION WITH METHOTREXATE CHOLINE SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON CHOLINE SALICYLATE CRITICAL INTERACTION WITH WARFARIN CIMETIDINE CRITICAL INTERACTION WITH AMINOPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH ANISINDIONE CIMETIDINE CRITICAL INTERACTION WITH CARMUSTINE CIMETIDINE CRITICAL INTERACTION WITH DICUMAROL CIMETIDINE CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM CIMETIDINE CRITICAL INTERACTION WITH OXTRIPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH PHENPROCOUMON CIMETIDINE CRITICAL INTERACTION WITH PHENYTOIN CIMETIDINE CRITICAL INTERACTION WITH THEOPHYLLINE CIMETIDINE CRITICAL INTERACTION WITH WARFARIN CIPROFLOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE CIPROFLOXACIN CRITICAL INTERACTION WITH OXTRIPHYLLINE CIPROFLOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE CISAPRIDE CRITICAL INTERACTION WITH CLARITHROMYCIN CISAPRIDE CRITICAL INTERACTION WITH ERYTHROMYCIN CISAPRIDE CRITICAL INTERACTION WITH FLUCONAZOLE CISAPRIDE CRITICAL INTERACTION WITH INDINAVIR SULFATE CISAPRIDE CRITICAL INTERACTION WITH ITRACONAZOLE CISAPRIDE CRITICAL INTERACTION WITH KETOCONAZOLE CISAPRIDE CRITICAL INTERACTION WITH MICONAZOLE

April 1998 National Drug File V. 3.18 175 User Manual Appendix D

CISAPRIDE CRITICAL INTERACTION WITH NEFAZODONE CISAPRIDE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CISAPRIDE CRITICAL INTERACTION WITH RITONAVIR CLARITHROMYCIN CRITICAL INTERACTION WITH AMINOPHYLLINE CLARITHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE CLARITHROMYCIN CRITICAL INTERACTION WITH CISAPRIDE CLARITHROMYCIN CRITICAL INTERACTION WITH CYCLOSPORINE CLARITHROMYCIN CRITICAL INTERACTION WITH DIGITALIS CLARITHROMYCIN CRITICAL INTERACTION WITH ERGOT CLARITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE CLARITHROMYCIN CRITICAL INTERACTION WITH OXTRIPHYLLINE CLARITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE CLARITHROMYCIN CRITICAL INTERACTION WITH TERFENADINE CLARITHROMYCIN CRITICAL INTERACTION WITH THEOPHYLLINE CLOFIBRATE CRITICAL INTERACTION WITH ANISINDIONE CLOFIBRATE CRITICAL INTERACTION WITH DICUMAROL CLOFIBRATE CRITICAL INTERACTION WITH PHENPROCOUMON CLOFIBRATE CRITICAL INTERACTION WITH WARFARIN CLOMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE CLOMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID CLOMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE CLOMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE CLOMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE CLOMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE CLONIDINE CRITICAL INTERACTION WITH AMITRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH AMOXAPINE CLONIDINE CRITICAL INTERACTION WITH CLOMIPRAMINE CLONIDINE CRITICAL INTERACTION WITH DESIPRAMINE CLONIDINE CRITICAL INTERACTION WITH DOXEPIN CLONIDINE CRITICAL INTERACTION WITH IMIPRAMINE CLONIDINE CRITICAL INTERACTION WITH NORTRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH PROTRIPTYLINE CLONIDINE CRITICAL INTERACTION WITH TRIMIPRAMINE COLCHICINE CRITICAL INTERACTION WITH CYCLOSPORINE COLCHICINE CRITICAL INTERACTION WITH ERYTHROMYCIN CYCLOSPORINE CRITICAL INTERACTION WITH AMIODARONE CYCLOSPORINE CRITICAL INTERACTION WITH CARBAMAZEPINE CYCLOSPORINE CRITICAL INTERACTION WITH CLARITHROMYCIN

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CYCLOSPORINE CRITICAL INTERACTION WITH COLCHICINE CYCLOSPORINE CRITICAL INTERACTION WITH DILTIAZEM CYCLOSPORINE CRITICAL INTERACTION WITH ERGOT CYCLOSPORINE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE CYCLOSPORINE CRITICAL INTERACTION WITH ERYTHROMYCIN CYCLOSPORINE CRITICAL INTERACTION WITH ETHOTOIN CYCLOSPORINE CRITICAL INTERACTION WITH ETOPOSIDE CYCLOSPORINE CRITICAL INTERACTION WITH FLUCONAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH FOSCARNET CYCLOSPORINE CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM CYCLOSPORINE CRITICAL INTERACTION WITH ITRACONAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH MEPHENYTOIN CYCLOSPORINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CYCLOSPORINE CRITICAL INTERACTION WITH PHENYTOIN CYCLOSPORINE CRITICAL INTERACTION WITH RIFABUTIN CYCLOSPORINE CRITICAL INTERACTION WITH RIFAMPIN CYCLOSPORINE CRITICAL INTERACTION WITH SULFACYTINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFADIAZINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFAMETHIZOLE CYCLOSPORINE CRITICAL INTERACTION WITH SULFAMETHOXAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH SULFASALAZINE CYCLOSPORINE CRITICAL INTERACTION WITH SULFISOXAZOLE CYCLOSPORINE CRITICAL INTERACTION WITH VERAPAMIL CYCLOTHIAZIDE CRITICAL INTERACTION WITH LITHIUM DANAZOL CRITICAL INTERACTION WITH ANISINDIONE DANAZOL CRITICAL INTERACTION WITH DICUMAROL DANAZOL CRITICAL INTERACTION WITH PHENPROCOUMON DAPSONE CRITICAL INTERACTION WITH DIDANOSINE DESIPRAMINE CRITICAL INTERACTION WITH CLONIDINE DESIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DESIPRAMINE CRITICAL INTERACTION WITH PARGYLINE DESIPRAMINE CRITICAL INTERACTION WITH PHENELZINE DESIPRAMINE CRITICAL INTERACTION WITH SELEGILINE DESIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DESOGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE DEXTROAMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DEXTROAMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE DEXTROAMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE

April 1998 National Drug File V. 3.18 177 User Manual Appendix D

DEXTROAMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH ISOCARBOXAZID DEXTROMETHORPHAN CRITICAL INTERACTION WITH PARGYLINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH PHENELZINE DEXTROMETHORPHAN CRITICAL INTERACTION WITH TRANYLCYPROMINE DICUMAROL CRITICAL INTERACTION WITH AMIODARONE DICUMAROL CRITICAL INTERACTION WITH AMOBARBITAL DICUMAROL CRITICAL INTERACTION WITH ASPIRIN DICUMAROL CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE DICUMAROL CRITICAL INTERACTION WITH CARBAMAZEPINE DICUMAROL CRITICAL INTERACTION WITH CHOLINE SALICYLATE DICUMAROL CRITICAL INTERACTION WITH CIMETIDINE DICUMAROL CRITICAL INTERACTION WITH CLOFIBRATE DICUMAROL CRITICAL INTERACTION WITH DANAZOL DICUMAROL CRITICAL INTERACTION WITH DISULFIRAM DICUMAROL CRITICAL INTERACTION WITH FLUCONAZOLE DICUMAROL CRITICAL INTERACTION WITH ITRACONAZOLE DICUMAROL CRITICAL INTERACTION WITH KETOCONAZOLE DICUMAROL CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE DICUMAROL CRITICAL INTERACTION WITH MEPHOBARBITAL DICUMAROL CRITICAL INTERACTION WITH METHYL SALICYLATE DICUMAROL CRITICAL INTERACTION WITH MICONAZOLE DICUMAROL CRITICAL INTERACTION WITH OXYPHENBUTAZONE DICUMAROL CRITICAL INTERACTION WITH PENTOBARBITAL DICUMAROL CRITICAL INTERACTION WITH PHENOBARBITAL DICUMAROL CRITICAL INTERACTION WITH PHENYLBUTAZONE DICUMAROL CRITICAL INTERACTION WITH PRIMIDONE DICUMAROL CRITICAL INTERACTION WITH RIFAMPIN DICUMAROL CRITICAL INTERACTION WITH SALSALATE DICUMAROL CRITICAL INTERACTION WITH SECOBARBITAL DICUMAROL CRITICAL INTERACTION WITH SODIUM SALICYLATE DICUMAROL CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE DIDANOSINE CRITICAL INTERACTION WITH DAPSONE DIETHYLPROPION CRITICAL INTERACTION WITH ISOCARBOXAZID DIETHYLPROPION CRITICAL INTERACTION WITH PARGYLINE DIETHYLPROPION CRITICAL INTERACTION WITH PHENELZINE DIETHYLPROPION CRITICAL INTERACTION WITH TRANYLCYPROMINE DIGITALIS CRITICAL INTERACTION WITH AMIODARONE

178 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

DIGITALIS CRITICAL INTERACTION WITH CLARITHROMYCIN DIGITALIS CRITICAL INTERACTION WITH ERYTHROMYCIN DIGITALIS CRITICAL INTERACTION WITH VERAPAMIL DILTIAZEM CRITICAL INTERACTION WITH CYCLOSPORINE DIRITHROMYCIN CRITICAL INTERACTION WITH ERGOT DIRITHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE DIRITHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE DISOPYRAMIDE CRITICAL INTERACTION WITH SPARFLOXACIN DISULFIRAM CRITICAL INTERACTION WITH ANISINDIONE DISULFIRAM CRITICAL INTERACTION WITH DICUMAROL DISULFIRAM CRITICAL INTERACTION WITH PHENPROCOUMON DISULFIRAM CRITICAL INTERACTION WITH WARFARIN DOPAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID DOPAMINE CRITICAL INTERACTION WITH PARGYLINE DOPAMINE CRITICAL INTERACTION WITH PHENELZINE DOPAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE DOXEPIN CRITICAL INTERACTION WITH CLONIDINE DOXEPIN CRITICAL INTERACTION WITH ISOCARBOXAZID DOXEPIN CRITICAL INTERACTION WITH PARGYLINE DOXEPIN CRITICAL INTERACTION WITH PHENELZINE DOXEPIN CRITICAL INTERACTION WITH SELEGILINE DOXEPIN CRITICAL INTERACTION WITH TRANYLCYPROMINE ENOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE ENOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE EPHEDRINE CRITICAL INTERACTION WITH ISOCARBOXAZID EPHEDRINE CRITICAL INTERACTION WITH PARGYLINE EPHEDRINE CRITICAL INTERACTION WITH PHENELZINE EPHEDRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE ERGOT CRITICAL INTERACTION WITH AZITHROMYCIN ERGOT CRITICAL INTERACTION WITH CLARITHROMYCIN ERGOT CRITICAL INTERACTION WITH CYCLOSPORINE ERGOT CRITICAL INTERACTION WITH DIRITHROMYCIN ERGOT CRITICAL INTERACTION WITH ERYTHROMYCIN ERGOT CRITICAL INTERACTION WITH FENFLURAMINE ERGOT CRITICAL INTERACTION WITH NITROGLYCERIN ERGOT CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ERGOT CRITICAL INTERACTION WITH PROPRANOLOL ERGOT CRITICAL INTERACTION WITH SUMATRIPTAN

April 1998 National Drug File V. 3.18 179 User Manual Appendix D

ERGOT CRITICAL INTERACTION WITH SUMATRIPTAN SUCCINATE ERGOT CRITICAL INTERACTION WITH TACROLIMUS ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH AZITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH CLARITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH CYCLOSPORINE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH DIRITHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH ERYTHROMYCIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH FENFLURAMINE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH NITROGLYCERIN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH PROPRANOLOL ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH SUMATRIPTAN ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH SUMATRIPTAN SUCCINATE ERGOTAMINE TARTRATE CRITICAL INTERACTION WITH TACROLIMUS ERYTHROMYCIN CRITICAL INTERACTION WITH AMINOPHYLLINE ERYTHROMYCIN CRITICAL INTERACTION WITH ASTEMIZOLE ERYTHROMYCIN CRITICAL INTERACTION WITH CISAPRIDE ERYTHROMYCIN CRITICAL INTERACTION WITH COLCHICINE ERYTHROMYCIN CRITICAL INTERACTION WITH CYCLOSPORINE ERYTHROMYCIN CRITICAL INTERACTION WITH DIGITALIS ERYTHROMYCIN CRITICAL INTERACTION WITH ERGOT ERYTHROMYCIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE ERYTHROMYCIN CRITICAL INTERACTION WITH PIMOZIDE ERYTHROMYCIN CRITICAL INTERACTION WITH TERFENADINE ERYTHROMYCIN CRITICAL INTERACTION WITH THEOPHYLLINE ERYTHROMYCIN CRITICAL INTERACTION WITH VINBLASTINE ETHINYL ESTRADIOL CRITICAL INTERACTION WITH CARBAMAZEPINE ETHOTOIN CRITICAL INTERACTION WITH CYCLOSPORINE ETHYNODIOL DIACETATE CRITICAL INTERACTION WITH CARBAMAZEPINE ETOPOSIDE CRITICAL INTERACTION WITH CYCLOSPORINE FENFLURAMINE CRITICAL INTERACTION WITH ERGOT FENFLURAMINE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE FENFLURAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID FENFLURAMINE CRITICAL INTERACTION WITH PARGYLINE FENFLURAMINE CRITICAL INTERACTION WITH PHENELZINE FENFLURAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE FENTANYL CRITICAL INTERACTION WITH AMIODARONE FLUCONAZOLE CRITICAL INTERACTION WITH ANISINDIONE

180 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

FLUCONAZOLE CRITICAL INTERACTION WITH CISAPRIDE FLUCONAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE FLUCONAZOLE CRITICAL INTERACTION WITH DICUMAROL FLUCONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON FLUCONAZOLE CRITICAL INTERACTION WITH RIFABUTIN FLUCONAZOLE CRITICAL INTERACTION WITH RIFAMPIN FLUCONAZOLE CRITICAL INTERACTION WITH TACROLIMUS FLUCONAZOLE CRITICAL INTERACTION WITH WARFARIN FLUOXETINE CRITICAL INTERACTION WITH ISOCARBOXAZID FLUOXETINE CRITICAL INTERACTION WITH PARGYLINE FLUOXETINE CRITICAL INTERACTION WITH PHENELZINE FLUOXETINE CRITICAL INTERACTION WITH SELEGILINE FLUOXETINE CRITICAL INTERACTION WITH TRANYLCYPROMINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH ASTEMIZOLE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH ISOCARBOXAZID FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH PARGYLINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH PHENELZINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH SELEGILINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH TERFENADINE FLUVOXAMINE MALEATE CRITICAL INTERACTION WITH TRANYLCYPROMINE FOSCARNET CRITICAL INTERACTION WITH CYCLOSPORINE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH CIMETIDINE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH CYCLOSPORINE FOSPHENYTOIN SODIUM CRITICAL INTERACTION WITH ISONIAZID GANCICLOVIR CRITICAL INTERACTION WITH ZIDOVUDINE GEMFIBROZIL CRITICAL INTERACTION WITH LOVASTATIN HYDROCHLOROTHIAZIDE CRITICAL INTERACTION WITH LITHIUM HYDROFLUMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM IMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE IMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID IMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE IMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE IMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE IMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE INDAPAMIDE CRITICAL INTERACTION WITH LITHIUM INDINAVIR SULFATE CRITICAL INTERACTION WITH ASTEMIZOLE INDINAVIR SULFATE CRITICAL INTERACTION WITH CISAPRIDE INDINAVIR SULFATE CRITICAL INTERACTION WITH TERFENADINE

April 1998 National Drug File V. 3.18 181 User Manual Appendix D

ISOCARBOXAZID CRITICAL INTERACTION WITH AMITRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH AMOXAPINE ISOCARBOXAZID CRITICAL INTERACTION WITH AMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH BENZPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH CLOMIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DESIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DEXTROAMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DEXTROMETHORPHAN ISOCARBOXAZID CRITICAL INTERACTION WITH DIETHYLPROPION ISOCARBOXAZID CRITICAL INTERACTION WITH DOPAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH DOXEPIN ISOCARBOXAZID CRITICAL INTERACTION WITH EPHEDRINE ISOCARBOXAZID CRITICAL INTERACTION WITH FENFLURAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH FLUOXETINE ISOCARBOXAZID CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE ISOCARBOXAZID CRITICAL INTERACTION WITH IMIPRAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH MEPERIDINE ISOCARBOXAZID CRITICAL INTERACTION WITH METHAMPHETAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH NORTRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH PAROXETINE ISOCARBOXAZID CRITICAL INTERACTION WITH PHENYLEPHRINE ISOCARBOXAZID CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE ISOCARBOXAZID CRITICAL INTERACTION WITH PROTRIPTYLINE ISOCARBOXAZID CRITICAL INTERACTION WITH PSEUDOEPHEDRINE ISOCARBOXAZID CRITICAL INTERACTION WITH SERTRALINE ISOCARBOXAZID CRITICAL INTERACTION WITH TRIMIPRAMINE ISONIAZID CRITICAL INTERACTION WITH CARBAMAZEPINE ISONIAZID CRITICAL INTERACTION WITH FOSPHENYTOIN SODIUM ISONIAZID CRITICAL INTERACTION WITH PHENYTOIN ITRACONAZOLE CRITICAL INTERACTION WITH ANISINDIONE ITRACONAZOLE CRITICAL INTERACTION WITH ASTEMIZOLE ITRACONAZOLE CRITICAL INTERACTION WITH CISAPRIDE ITRACONAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE ITRACONAZOLE CRITICAL INTERACTION WITH DICUMAROL ITRACONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON ITRACONAZOLE CRITICAL INTERACTION WITH RIFABUTIN ITRACONAZOLE CRITICAL INTERACTION WITH RIFAMPIN ITRACONAZOLE CRITICAL INTERACTION WITH TERFENADINE

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ITRACONAZOLE CRITICAL INTERACTION WITH WARFARIN KETOCONAZOLE CRITICAL INTERACTION WITH ANISINDIONE KETOCONAZOLE CRITICAL INTERACTION WITH ASTEMIZOLE KETOCONAZOLE CRITICAL INTERACTION WITH CISAPRIDE KETOCONAZOLE CRITICAL INTERACTION WITH DICUMAROL KETOCONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON KETOCONAZOLE CRITICAL INTERACTION WITH RIFABUTIN KETOCONAZOLE CRITICAL INTERACTION WITH RIFAMPIN KETOCONAZOLE CRITICAL INTERACTION WITH TERFENADINE KETOCONAZOLE CRITICAL INTERACTION WITH WARFARIN KETOROLAC TROMETHAMINE CRITICAL INTERACTION WITH PROBENECID LABETALOL CRITICAL INTERACTION WITH VERAPAMIL LEVONORGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE LITHIUM CRITICAL INTERACTION WITH BENDROFLUMETHIAZIDE LITHIUM CRITICAL INTERACTION WITH BENZTHIAZIDE LITHIUM CRITICAL INTERACTION WITH CHLOROTHIAZIDE LITHIUM CRITICAL INTERACTION WITH CHLORTHALIDONE LITHIUM CRITICAL INTERACTION WITH CYCLOTHIAZIDE LITHIUM CRITICAL INTERACTION WITH HYDROCHLOROTHIAZIDE LITHIUM CRITICAL INTERACTION WITH HYDROFLUMETHIAZIDE LITHIUM CRITICAL INTERACTION WITH INDAPAMIDE LITHIUM CRITICAL INTERACTION WITH METHYCLOTHIAZIDE LITHIUM CRITICAL INTERACTION WITH METOLAZONE LITHIUM CRITICAL INTERACTION WITH POLYTHIAZIDE LITHIUM CRITICAL INTERACTION WITH QUINETHAZONE LITHIUM CRITICAL INTERACTION WITH TRICHLORMETHIAZIDE LOVASTATIN CRITICAL INTERACTION WITH GEMFIBROZIL MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH DICUMAROL MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON MAGNESIUM SALICYLATE CRITICAL INTERACTION WITH WARFARIN MEDROXYPROGESTERONE CRITICAL INTERACTION WITH CARBAMAZEPINE MEPERIDINE CRITICAL INTERACTION WITH ISOCARBOXAZID MEPERIDINE CRITICAL INTERACTION WITH PARGYLINE MEPERIDINE CRITICAL INTERACTION WITH PHENELZINE MEPERIDINE CRITICAL INTERACTION WITH TRANYLCYPROMINE MEPHENYTOIN CRITICAL INTERACTION WITH CYCLOSPORINE MEPHOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE

April 1998 National Drug File V. 3.18 183 User Manual Appendix D

MEPHOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE MEPHOBARBITAL CRITICAL INTERACTION WITH DICUMAROL MEPHOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON MERCAPTOPURINE CRITICAL INTERACTION WITH ALLOPURINOL MESTRANOL CRITICAL INTERACTION WITH CARBAMAZEPINE METHAMPHETAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID METHAMPHETAMINE CRITICAL INTERACTION WITH PARGYLINE METHAMPHETAMINE CRITICAL INTERACTION WITH PHENELZINE METHAMPHETAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE METHOTREXATE CRITICAL INTERACTION WITH ASPIRIN METHOTREXATE CRITICAL INTERACTION WITH CHOLINE SALICYLATE METHYCLOTHIAZIDE CRITICAL INTERACTION WITH LITHIUM METHYL SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE METHYL SALICYLATE CRITICAL INTERACTION WITH DICUMAROL METHYL SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON METOLAZONE CRITICAL INTERACTION WITH LITHIUM METOPROLOL CRITICAL INTERACTION WITH VERAPAMIL MICONAZOLE CRITICAL INTERACTION WITH ANISINDIONE MICONAZOLE CRITICAL INTERACTION WITH CISAPRIDE MICONAZOLE CRITICAL INTERACTION WITH DICUMAROL MICONAZOLE CRITICAL INTERACTION WITH PHENPROCOUMON MICONAZOLE CRITICAL INTERACTION WITH WARFARIN NADOLOL CRITICAL INTERACTION WITH VERAPAMIL NEFAZODONE CRITICAL INTERACTION WITH ASTEMIZOLE NEFAZODONE CRITICAL INTERACTION WITH CISAPRIDE NEFAZODONE CRITICAL INTERACTION WITH TERFENADINE NITROGLYCERIN CRITICAL INTERACTION WITH ALTEPLASE NITROGLYCERIN CRITICAL INTERACTION WITH ERGOT NITROGLYCERIN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE NORETHINDRONE CRITICAL INTERACTION WITH CARBAMAZEPINE NORETHYNODREL CRITICAL INTERACTION WITH CARBAMAZEPINE NORFLOXACIN CRITICAL INTERACTION WITH AMINOPHYLLINE NORFLOXACIN CRITICAL INTERACTION WITH THEOPHYLLINE NORGESTIMATE CRITICAL INTERACTION WITH CARBAMAZEPINE NORGESTREL CRITICAL INTERACTION WITH CARBAMAZEPINE NORTRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE NORTRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID NORTRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE

184 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

NORTRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE NORTRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE NORTRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH AMINOPHYLLINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ASTEMIZOLE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH CISAPRIDE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH CYCLOSPORINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ERGOT OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH TERFENADINE OLEANDOMYCIN (AS TROLEANDOMYCIN) CRITICAL INTERACTION WITH THEOPHYLLINE OXTRIPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE OXTRIPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN OXTRIPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN OXYPHENBUTAZONE CRITICAL INTERACTION WITH ANISINDIONE OXYPHENBUTAZONE CRITICAL INTERACTION WITH DICUMAROL OXYPHENBUTAZONE CRITICAL INTERACTION WITH PHENPROCOUMON PARGYLINE CRITICAL INTERACTION WITH AMITRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH AMOXAPINE PARGYLINE CRITICAL INTERACTION WITH AMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH BENZPHETAMINE PARGYLINE CRITICAL INTERACTION WITH CLOMIPRAMINE PARGYLINE CRITICAL INTERACTION WITH DESIPRAMINE PARGYLINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN PARGYLINE CRITICAL INTERACTION WITH DIETHYLPROPION PARGYLINE CRITICAL INTERACTION WITH DOPAMINE PARGYLINE CRITICAL INTERACTION WITH DOXEPIN PARGYLINE CRITICAL INTERACTION WITH EPHEDRINE PARGYLINE CRITICAL INTERACTION WITH FENFLURAMINE PARGYLINE CRITICAL INTERACTION WITH FLUOXETINE PARGYLINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE PARGYLINE CRITICAL INTERACTION WITH IMIPRAMINE PARGYLINE CRITICAL INTERACTION WITH MEPERIDINE PARGYLINE CRITICAL INTERACTION WITH METHAMPHETAMINE PARGYLINE CRITICAL INTERACTION WITH NORTRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH PAROXETINE PARGYLINE CRITICAL INTERACTION WITH PHENYLEPHRINE

April 1998 National Drug File V. 3.18 185 User Manual Appendix D

PARGYLINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE PARGYLINE CRITICAL INTERACTION WITH PROTRIPTYLINE PARGYLINE CRITICAL INTERACTION WITH PSEUDOEPHEDRINE PARGYLINE CRITICAL INTERACTION WITH SERTRALINE PARGYLINE CRITICAL INTERACTION WITH TRIMIPRAMINE PAROXETINE CRITICAL INTERACTION WITH ISOCARBOXAZID PAROXETINE CRITICAL INTERACTION WITH PARGYLINE PAROXETINE CRITICAL INTERACTION WITH PHENELZINE PAROXETINE CRITICAL INTERACTION WITH SELEGILINE PAROXETINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PENBUTOLOL CRITICAL INTERACTION WITH VERAPAMIL PENTOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE PENTOBARBITAL CRITICAL INTERACTION WITH DICUMAROL PENTOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON PENTOBARBITAL CRITICAL INTERACTION WITH WARFARIN PHENELZINE CRITICAL INTERACTION WITH AMITRIPTYLINE PHENELZINE CRITICAL INTERACTION WITH AMOXAPINE PHENELZINE CRITICAL INTERACTION WITH AMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH BENZPHETAMINE PHENELZINE CRITICAL INTERACTION WITH CLOMIPRAMINE PHENELZINE CRITICAL INTERACTION WITH DESIPRAMINE PHENELZINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN PHENELZINE CRITICAL INTERACTION WITH DIETHYLPROPION PHENELZINE CRITICAL INTERACTION WITH DOPAMINE PHENELZINE CRITICAL INTERACTION WITH DOXEPIN PHENELZINE CRITICAL INTERACTION WITH EPHEDRINE PHENELZINE CRITICAL INTERACTION WITH FENFLURAMINE PHENELZINE CRITICAL INTERACTION WITH FLUOXETINE PHENELZINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE PHENELZINE CRITICAL INTERACTION WITH IMIPRAMINE PHENELZINE CRITICAL INTERACTION WITH MEPERIDINE PHENELZINE CRITICAL INTERACTION WITH METHAMPHETAMINE PHENELZINE CRITICAL INTERACTION WITH NORTRIPTYLINE PHENELZINE CRITICAL INTERACTION WITH PAROXETINE PHENELZINE CRITICAL INTERACTION WITH PHENYLEPHRINE PHENELZINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE PHENELZINE CRITICAL INTERACTION WITH PROTRIPTYLINE

186 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

PHENELZINE CRITICAL INTERACTION WITH SERTRALINE PHENELZINE CRITICAL INTERACTION WITH TRIMIPRAMINE PHENOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE PHENOBARBITAL CRITICAL INTERACTION WITH DICUMAROL PHENOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON PHENOBARBITAL CRITICAL INTERACTION WITH WARFARIN PHENPROCOUMON CRITICAL INTERACTION WITH AMIODARONE PHENPROCOUMON CRITICAL INTERACTION WITH AMOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH ASPIRIN PHENPROCOUMON CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH CARBAMAZEPINE PHENPROCOUMON CRITICAL INTERACTION WITH CHOLINE SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH CIMETIDINE PHENPROCOUMON CRITICAL INTERACTION WITH CLOFIBRATE PHENPROCOUMON CRITICAL INTERACTION WITH DANAZOL PHENPROCOUMON CRITICAL INTERACTION WITH DISULFIRAM PHENPROCOUMON CRITICAL INTERACTION WITH FLUCONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH ITRACONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH KETOCONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH MEPHOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH METHYL SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH MICONAZOLE PHENPROCOUMON CRITICAL INTERACTION WITH OXYPHENBUTAZONE PHENPROCOUMON CRITICAL INTERACTION WITH PENTOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH PHENOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH PHENYLBUTAZONE PHENPROCOUMON CRITICAL INTERACTION WITH PRIMIDONE PHENPROCOUMON CRITICAL INTERACTION WITH RIFAMPIN PHENPROCOUMON CRITICAL INTERACTION WITH SALSALATE PHENPROCOUMON CRITICAL INTERACTION WITH SECOBARBITAL PHENPROCOUMON CRITICAL INTERACTION WITH SODIUM SALICYLATE PHENPROCOUMON CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE PHENYLBUTAZONE CRITICAL INTERACTION WITH ANISINDIONE PHENYLBUTAZONE CRITICAL INTERACTION WITH DICUMAROL PHENYLBUTAZONE CRITICAL INTERACTION WITH PHENPROCOUMON PHENYLBUTAZONE CRITICAL INTERACTION WITH WARFARIN PHENYLEPHRINE CRITICAL INTERACTION WITH ISOCARBOXAZID

April 1998 National Drug File V. 3.18 187 User Manual Appendix D

PHENYLEPHRINE CRITICAL INTERACTION WITH PARGYLINE PHENYLEPHRINE CRITICAL INTERACTION WITH PHENELZINE PHENYLEPHRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH PARGYLINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH PHENELZINE PHENYLPROPANOLAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PHENYTOIN CRITICAL INTERACTION WITH CIMETIDINE PHENYTOIN CRITICAL INTERACTION WITH CYCLOSPORINE PHENYTOIN CRITICAL INTERACTION WITH ISONIAZID PIMOZIDE CRITICAL INTERACTION WITH AZITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH CLARITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH DIRITHROMYCIN PIMOZIDE CRITICAL INTERACTION WITH ERYTHROMYCIN PINDOLOL CRITICAL INTERACTION WITH VERAPAMIL POLYTHIAZIDE CRITICAL INTERACTION WITH LITHIUM PRIMIDONE CRITICAL INTERACTION WITH ANISINDIONE PRIMIDONE CRITICAL INTERACTION WITH DICUMAROL PRIMIDONE CRITICAL INTERACTION WITH PHENPROCOUMON PRIMIDONE CRITICAL INTERACTION WITH WARFARIN PROBENECID CRITICAL INTERACTION WITH ASPIRIN PROBENECID CRITICAL INTERACTION WITH KETOROLAC TROMETHAMINE PROPRANOLOL CRITICAL INTERACTION WITH ERGOT PROPRANOLOL CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE PROPRANOLOL CRITICAL INTERACTION WITH VERAPAMIL PROTRIPTYLINE CRITICAL INTERACTION WITH CLONIDINE PROTRIPTYLINE CRITICAL INTERACTION WITH ISOCARBOXAZID PROTRIPTYLINE CRITICAL INTERACTION WITH PARGYLINE PROTRIPTYLINE CRITICAL INTERACTION WITH PHENELZINE PROTRIPTYLINE CRITICAL INTERACTION WITH SELEGILINE PROTRIPTYLINE CRITICAL INTERACTION WITH TRANYLCYPROMINE PSEUDOEPHEDRINE CRITICAL INTERACTION WITH ISOCARBOXAZID PSEUDOEPHEDRINE CRITICAL INTERACTION WITH PARGYLINE PSEUDOEPHEDRINE CRITICAL INTERACTION WITH TRANYLCYPROMINE QUINETHAZONE CRITICAL INTERACTION WITH LITHIUM QUINIDINE CRITICAL INTERACTION WITH AMIODARONE QUININE CRITICAL INTERACTION WITH ASTEMIZOLE QUININE CRITICAL INTERACTION WITH TERFENADINE

188 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

RIFABUTIN CRITICAL INTERACTION WITH CYCLOSPORINE RIFABUTIN CRITICAL INTERACTION WITH FLUCONAZOLE RIFABUTIN CRITICAL INTERACTION WITH ITRACONAZOLE RIFABUTIN CRITICAL INTERACTION WITH KETOCONAZOLE RIFAMPIN CRITICAL INTERACTION WITH ANISINDIONE RIFAMPIN CRITICAL INTERACTION WITH CYCLOSPORINE RIFAMPIN CRITICAL INTERACTION WITH DICUMAROL RIFAMPIN CRITICAL INTERACTION WITH FLUCONAZOLE RIFAMPIN CRITICAL INTERACTION WITH ITRACONAZOLE RIFAMPIN CRITICAL INTERACTION WITH KETOCONAZOLE RIFAMPIN CRITICAL INTERACTION WITH PHENPROCOUMON RIFAMPIN CRITICAL INTERACTION WITH WARFARIN RITONAVIR CRITICAL INTERACTION WITH ASTEMIZOLE RITONAVIR CRITICAL INTERACTION WITH CISAPRIDE RITONAVIR CRITICAL INTERACTION WITH TERFENADINE SALSALATE CRITICAL INTERACTION WITH ANISINDIONE SALSALATE CRITICAL INTERACTION WITH DICUMAROL SALSALATE CRITICAL INTERACTION WITH PHENPROCOUMON SALSALATE CRITICAL INTERACTION WITH WARFARIN SECOBARBITAL CRITICAL INTERACTION WITH ANISINDIONE SECOBARBITAL CRITICAL INTERACTION WITH DICUMAROL SECOBARBITAL CRITICAL INTERACTION WITH PHENPROCOUMON SECOBARBITAL CRITICAL INTERACTION WITH WARFARIN SELEGILINE CRITICAL INTERACTION WITH AMITRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH AMOXAPINE SELEGILINE CRITICAL INTERACTION WITH CLOMIPRAMINE SELEGILINE CRITICAL INTERACTION WITH DESIPRAMINE SELEGILINE CRITICAL INTERACTION WITH DOXEPIN SELEGILINE CRITICAL INTERACTION WITH FLUOXETINE SELEGILINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE SELEGILINE CRITICAL INTERACTION WITH IMIPRAMINE SELEGILINE CRITICAL INTERACTION WITH NORTRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH PAROXETINE SELEGILINE CRITICAL INTERACTION WITH PROTRIPTYLINE SELEGILINE CRITICAL INTERACTION WITH SERTRALINE SELEGILINE CRITICAL INTERACTION WITH TRIMIPRAMINE SERTRALINE CRITICAL INTERACTION WITH ISOCARBOXAZID SERTRALINE CRITICAL INTERACTION WITH PARGYLINE

April 1998 National Drug File V. 3.18 189 User Manual Appendix D

SERTRALINE CRITICAL INTERACTION WITH PHENELZINE SERTRALINE CRITICAL INTERACTION WITH SELEGILINE SERTRALINE CRITICAL INTERACTION WITH TRANYLCYPROMINE SODIUM SALICYLATE CRITICAL INTERACTION WITH ANISINDIONE SODIUM SALICYLATE CRITICAL INTERACTION WITH DICUMAROL SODIUM SALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON SODIUM SALICYLATE CRITICAL INTERACTION WITH WARFARIN SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH ANISINDIONE SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH DICUMAROL SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH PHENPROCOUMON SODIUM THIOSALICYLATE CRITICAL INTERACTION WITH WARFARIN SOTALOL CRITICAL INTERACTION WITH VERAPAMIL SPARFLOXACIN CRITICAL INTERACTION WITH AMIODARONE SPARFLOXACIN CRITICAL INTERACTION WITH DISOPYRAMIDE SULFACYTINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFADIAZINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFAMETHIZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SULFAMETHOXAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SULFASALAZINE CRITICAL INTERACTION WITH CYCLOSPORINE SULFISOXAZOLE CRITICAL INTERACTION WITH CYCLOSPORINE SUMATRIPTAN CRITICAL INTERACTION WITH ERGOT SUMATRIPTAN CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE SUMATRIPTAN SUCCINATE CRITICAL INTERACTION WITH ERGOT SUMATRIPTAN SUCCINATE CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE TACRINE HYDROCHLORIDE CRITICAL INTERACTION WITH THEOPHYLLINE TACROLIMUS CRITICAL INTERACTION WITH ERGOT TACROLIMUS CRITICAL INTERACTION WITH ERGOTAMINE TARTRATE TACROLIMUS CRITICAL INTERACTION WITH FLUCONAZOLE TERFENADINE CRITICAL INTERACTION WITH AZITHROMYCIN TERFENADINE CRITICAL INTERACTION WITH CLARITHROMYCIN TERFENADINE CRITICAL INTERACTION WITH ERYTHROMYCIN TERFENADINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE TERFENADINE CRITICAL INTERACTION WITH INDINAVIR SULFATE TERFENADINE CRITICAL INTERACTION WITH ITRACONAZOLE TERFENADINE CRITICAL INTERACTION WITH KETOCONAZOLE TERFENADINE CRITICAL INTERACTION WITH NEFAZODONE TERFENADINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) TERFENADINE CRITICAL INTERACTION WITH QUININE

190 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

TERFENADINE CRITICAL INTERACTION WITH RITONAVIR THEOPHYLLINE CRITICAL INTERACTION WITH CIMETIDINE THEOPHYLLINE CRITICAL INTERACTION WITH CIPROFLOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH CLARITHROMYCIN THEOPHYLLINE CRITICAL INTERACTION WITH ENOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH ERYTHROMYCIN THEOPHYLLINE CRITICAL INTERACTION WITH NORFLOXACIN THEOPHYLLINE CRITICAL INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) THEOPHYLLINE CRITICAL INTERACTION WITH TACRINE HYDROCHLORIDE TIMOLOL CRITICAL INTERACTION WITH VERAPAMIL TRANYLCYPROMINE CRITICAL INTERACTION WITH AMITRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH AMOXAPINE TRANYLCYPROMINE CRITICAL INTERACTION WITH AMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH BENZPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH CLOMIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DESIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DEXTROAMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DEXTROMETHORPHAN TRANYLCYPROMINE CRITICAL INTERACTION WITH DIETHYLPROPION TRANYLCYPROMINE CRITICAL INTERACTION WITH DOPAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH DOXEPIN TRANYLCYPROMINE CRITICAL INTERACTION WITH EPHEDRINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FENFLURAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FLUOXETINE TRANYLCYPROMINE CRITICAL INTERACTION WITH FLUVOXAMINE MALEATE TRANYLCYPROMINE CRITICAL INTERACTION WITH IMIPRAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH MEPERIDINE TRANYLCYPROMINE CRITICAL INTERACTION WITH METHAMPHETAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH NORTRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PAROXETINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PHENYLEPHRINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PHENYLPROPANOLAMINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PROTRIPTYLINE TRANYLCYPROMINE CRITICAL INTERACTION WITH PSEUDOEPHEDRINE TRANYLCYPROMINE CRITICAL INTERACTION WITH SERTRALINE TRANYLCYPROMINE CRITICAL INTERACTION WITH TRIMIPRAMINE TRICHLORMETHIAZIDE CRITICAL INTERACTION WITH LITHIUM TRIMIPRAMINE CRITICAL INTERACTION WITH CLONIDINE

April 1998 National Drug File V. 3.18 191 User Manual Appendix D

TRIMIPRAMINE CRITICAL INTERACTION WITH ISOCARBOXAZID TRIMIPRAMINE CRITICAL INTERACTION WITH PARGYLINE TRIMIPRAMINE CRITICAL INTERACTION WITH PHENELZINE TRIMIPRAMINE CRITICAL INTERACTION WITH SELEGILINE TRIMIPRAMINE CRITICAL INTERACTION WITH TRANYLCYPROMINE VERAPAMIL CRITICAL INTERACTION WITH ACEBUTOLOL VERAPAMIL CRITICAL INTERACTION WITH ATENOLOL VERAPAMIL CRITICAL INTERACTION WITH BETAXOLOL VERAPAMIL CRITICAL INTERACTION WITH BISOPROLOL FUMARATE VERAPAMIL CRITICAL INTERACTION WITH CARTEOLOL VERAPAMIL CRITICAL INTERACTION WITH CYCLOSPORINE VERAPAMIL CRITICAL INTERACTION WITH DIGITALIS VERAPAMIL CRITICAL INTERACTION WITH LABETALOL VERAPAMIL CRITICAL INTERACTION WITH METOPROLOL VERAPAMIL CRITICAL INTERACTION WITH NADOLOL VERAPAMIL CRITICAL INTERACTION WITH PENBUTOLOL VERAPAMIL CRITICAL INTERACTION WITH PINDOLOL VERAPAMIL CRITICAL INTERACTION WITH PROPRANOLOL VERAPAMIL CRITICAL INTERACTION WITH SOTALOL VERAPAMIL CRITICAL INTERACTION WITH TIMOLOL VINBLASTINE CRITICAL INTERACTION WITH ERYTHROMYCIN WARFARIN CRITICAL INTERACTION WITH AMIODARONE WARFARIN CRITICAL INTERACTION WITH AMOBARBITAL WARFARIN CRITICAL INTERACTION WITH ASPIRIN WARFARIN CRITICAL INTERACTION WITH BISMUTH SUBSALICYLATE WARFARIN CRITICAL INTERACTION WITH CARBAMAZEPINE WARFARIN CRITICAL INTERACTION WITH CHOLINE SALICYLATE WARFARIN CRITICAL INTERACTION WITH CIMETIDINE WARFARIN CRITICAL INTERACTION WITH CLOFIBRATE WARFARIN CRITICAL INTERACTION WITH DISULFIRAM WARFARIN CRITICAL INTERACTION WITH FLUCONAZOLE WARFARIN CRITICAL INTERACTION WITH ITRACONAZOLE WARFARIN CRITICAL INTERACTION WITH KETOCONAZOLE WARFARIN CRITICAL INTERACTION WITH MAGNESIUM SALICYLATE WARFARIN CRITICAL INTERACTION WITH MICONAZOLE WARFARIN CRITICAL INTERACTION WITH PENTOBARBITAL WARFARIN CRITICAL INTERACTION WITH PHENOBARBITAL WARFARIN CRITICAL INTERACTION WITH PHENYLBUTAZONE

192 National Drug File V. 3.18 April 1998 User Manual Critical Drug Interactions

WARFARIN CRITICAL INTERACTION WITH PRIMIDONE WARFARIN CRITICAL INTERACTION WITH RIFAMPIN WARFARIN CRITICAL INTERACTION WITH SALSALATE WARFARIN CRITICAL INTERACTION WITH SECOBARBITAL WARFARIN CRITICAL INTERACTION WITH SODIUM SALICYLATE WARFARIN CRITICAL INTERACTION WITH SODIUM THIOSALICYLATE ZIDOVUDINE CRITICAL INTERACTION WITH GANCICLOVIR

April 1998 National Drug File V. 3.18 193 User Manual Appendix D

Significant Drug Interactions List

ACEBUTOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH CLONIDINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ACEBUTOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN ACEBUTOLOL SIGNIFICANT INTERACTION WITH INSULIN ACEBUTOLOL SIGNIFICANT INTERACTION WITH PIROXICAM ACEBUTOLOL SIGNIFICANT INTERACTION WITH SULINDAC ACEBUTOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE ACEBUTOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE ACETAMINOPHEN SIGNIFICANT INTERACTION WITH SULFINPYRAZONE ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH LABETALOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH NADOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH SOTALOL ACETOHEXAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL ALFENTANIL SIGNIFICANT INTERACTION WITH ERYTHROMYCIN ALPRAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE ALPRAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN

194 National Drug File V. 3.18 April 1998 User Manual Significant Drug Interactions

ALUMINUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN ALUMINUM HYDROXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH ENOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN ALUMINUM PHOSPHATE SIGNIFICANT INTERACTION WITH TETRACYCLINE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH BETAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH CORTICOTROPIN AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH CORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH COSYNTROPIN AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH DESOXYCORTICOSTERONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH DEXAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH HYDROCORTISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH METHYLPREDNISOLONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PARAMETHASONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PREDNISOLONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH PREDNISONE AMBENONIUM CHLORIDE SIGNIFICANT INTERACTION WITH TRIAMCINOLONE AMIKACIN SIGNIFICANT INTERACTION WITH AMPICILLIN AMIKACIN SIGNIFICANT INTERACTION WITH ATRACURIUM AMIKACIN SIGNIFICANT INTERACTION WITH BUMETANIDE AMIKACIN SIGNIFICANT INTERACTION WITH CARBENICILLIN AMIKACIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID AMIKACIN SIGNIFICANT INTERACTION WITH FUROSEMIDE AMIKACIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE AMIKACIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE AMIKACIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN AMIKACIN SIGNIFICANT INTERACTION WITH PANCURONIUM AMIKACIN SIGNIFICANT INTERACTION WITH PIPERACILLIN AMIKACIN SIGNIFICANT INTERACTION WITH TICARCILLIN AMIKACIN SIGNIFICANT INTERACTION WITH TORSEMIDE AMIKACIN SIGNIFICANT INTERACTION WITH TUBOCURARINE

April 1998 National Drug File V. 3.18 195 User Manual Appendix D

AMIKACIN SIGNIFICANT INTERACTION WITH VANCOMYCIN AMIKACIN SIGNIFICANT INTERACTION WITH VECURONIUM AMILORIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL AMILORIDE SIGNIFICANT INTERACTION WITH CAPTOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH ENALAPRIL AMILORIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH LISINOPRIL AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM IODIDE AMILORIDE SIGNIFICANT INTERACTION WITH POTASSIUM PHOSPHATE AMILORIDE SIGNIFICANT INTERACTION WITH QUINAPRIL AMILORIDE SIGNIFICANT INTERACTION WITH QUINIDINE AMILORIDE SIGNIFICANT INTERACTION WITH RAMIPRIL AMILORIDE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMINOPHYLLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM AMINOPHYLLINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL AMINOPHYLLINE SIGNIFICANT INTERACTION WITH PHENYTOIN AMINOPHYLLINE SIGNIFICANT INTERACTION WITH RIFAMPIN AMIODARONE SIGNIFICANT INTERACTION WITH RITONAVIR AMITRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMITRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMOXAPINE SIGNIFICANT INTERACTION WITH FLUOXETINE AMOXAPINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE AMPICILLIN SIGNIFICANT INTERACTION WITH AMIKACIN AMPICILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN AMPICILLIN SIGNIFICANT INTERACTION WITH NETILMICIN AMPICILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN ANISINDIONE SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE ANISINDIONE SIGNIFICANT INTERACTION WITH DICLOFENAC ANISINDIONE SIGNIFICANT INTERACTION WITH DIFLUNISAL ANISINDIONE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN ANISINDIONE SIGNIFICANT INTERACTION WITH ETODOLAC

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ANISINDIONE SIGNIFICANT INTERACTION WITH FENOPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH FLURBIPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH IBUPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH INDOMETHACIN ANISINDIONE SIGNIFICANT INTERACTION WITH KETOPROFEN ANISINDIONE SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE ANISINDIONE SIGNIFICANT INTERACTION WITH LEVAMISOLE ANISINDIONE SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM ANISINDIONE SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID ANISINDIONE SIGNIFICANT INTERACTION WITH MEFENAMIC ACID ANISINDIONE SIGNIFICANT INTERACTION WITH METHIMAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH METRONIDAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH NABUMETONE ANISINDIONE SIGNIFICANT INTERACTION WITH NAPROXEN ANISINDIONE SIGNIFICANT INTERACTION WITH OXAPROZIN ANISINDIONE SIGNIFICANT INTERACTION WITH PAROXETINE ANISINDIONE SIGNIFICANT INTERACTION WITH PHENYTOIN ANISINDIONE SIGNIFICANT INTERACTION WITH PHYTONADIONE ANISINDIONE SIGNIFICANT INTERACTION WITH PIROXICAM ANISINDIONE SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL ANISINDIONE SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH SULFINPYRAZONE ANISINDIONE SIGNIFICANT INTERACTION WITH SULFISOXAZOLE ANISINDIONE SIGNIFICANT INTERACTION WITH SULINDAC ANISINDIONE SIGNIFICANT INTERACTION WITH THYROGLOBULIN ANISINDIONE SIGNIFICANT INTERACTION WITH THYROID ANISINDIONE SIGNIFICANT INTERACTION WITH TOLMETIN ANISINDIONE SIGNIFICANT INTERACTION WITH VITAMIN E ANISINDIONE SIGNIFICANT INTERACTION WITH VITAMIN K ASPIRIN SIGNIFICANT INTERACTION WITH HEPARIN ASTEMIZOLE SIGNIFICANT INTERACTION WITH SOTALOL ATENOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH CLONIDINE ATENOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE

April 1998 National Drug File V. 3.18 197 User Manual Appendix D

ATENOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ATENOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE ATENOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE ATENOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN ATENOLOL SIGNIFICANT INTERACTION WITH INSULIN ATENOLOL SIGNIFICANT INTERACTION WITH PIROXICAM ATENOLOL SIGNIFICANT INTERACTION WITH SULINDAC ATENOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE ATENOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE ATOVAQUONE SIGNIFICANT INTERACTION WITH ZIDOVUDINE ATRACURIUM SIGNIFICANT INTERACTION WITH AMIKACIN ATRACURIUM SIGNIFICANT INTERACTION WITH GENTAMICIN ATRACURIUM SIGNIFICANT INTERACTION WITH NEOMYCIN ATRACURIUM SIGNIFICANT INTERACTION WITH NETILMICIN ATRACURIUM SIGNIFICANT INTERACTION WITH STREPTOMYCIN ATRACURIUM SIGNIFICANT INTERACTION WITH TOBRAMYCIN ATROPINE SIGNIFICANT INTERACTION WITH CISAPRIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH AMILORIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID BENAZEPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN BENAZEPRIL SIGNIFICANT INTERACTION WITH LITHIUM BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE BENAZEPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE BENAZEPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE BENAZEPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE BENDROFLUMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS BENZTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS BEPRIDIL SIGNIFICANT INTERACTION WITH RITONAVIR BETAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE BETAMETHASONE SIGNIFICANT INTERACTION WITH EDROPHONIUM BETAMETHASONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE BETAMETHASONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE BETAMETHASONE SIGNIFICANT INTERACTION WITH RIFABUTIN

198 National Drug File V. 3.18 April 1998 User Manual Significant Drug Interactions

BETAMETHASONE SIGNIFICANT INTERACTION WITH RIFAMPIN BETAXOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE BETAXOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE BETAXOLOL SIGNIFICANT INTERACTION WITH CLONIDINE BETAXOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE BETAXOLOL SIGNIFICANT INTERACTION WITH FELODIPINE BETAXOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE BETAXOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE BETAXOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN BETAXOLOL SIGNIFICANT INTERACTION WITH INSULIN BETAXOLOL SIGNIFICANT INTERACTION WITH PIROXICAM BETAXOLOL SIGNIFICANT INTERACTION WITH SULINDAC BETAXOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE BETAXOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE BISMUTH SUBSALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN BISMUTH SUBSALICYLATE SIGNIFICANT INTERACTION WITH METHOTREXATE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH CIMETIDINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH EPINEPHRINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH FELODIPINE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH GLIPIZIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH GLYBURIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH INDOMETHACIN BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH INSULIN BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH PIROXICAM BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH SULINDAC BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH TOLAZAMIDE BISOPROLOL FUMARATE SIGNIFICANT INTERACTION WITH TOLBUTAMIDE BROMOCRIPTINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN BROMOCRIPTINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE BROMOCRIPTINE SIGNIFICANT INTERACTION WITH PHENYLPROPANOLAMINE BUMETANIDE SIGNIFICANT INTERACTION WITH AMIKACIN BUMETANIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH DIGITALIS BUMETANIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH GENTAMICIN BUMETANIDE SIGNIFICANT INTERACTION WITH KANAMYCIN

April 1998 National Drug File V. 3.18 199 User Manual Appendix D

BUMETANIDE SIGNIFICANT INTERACTION WITH NETILMICIN BUMETANIDE SIGNIFICANT INTERACTION WITH QUINAPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH RAMIPRIL BUMETANIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN BUMETANIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN BUPROPION SIGNIFICANT INTERACTION WITH CARBAMAZEPINE BUTABARBITAL SIGNIFICANT INTERACTION WITH DICUMAROL BUTALBITAL SIGNIFICANT INTERACTION WITH DICUMAROL BUTALBITAL SIGNIFICANT INTERACTION WITH WARFARIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN CALCIUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE CAPTOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE CAPTOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN CAPTOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE CAPTOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH BUPROPION CARBAMAZEPINE SIGNIFICANT INTERACTION WITH CLARITHROMYCIN CARBAMAZEPINE SIGNIFICANT INTERACTION WITH DANAZOL CARBAMAZEPINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN CARBAMAZEPINE SIGNIFICANT INTERACTION WITH FELBAMATE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH FELODIPINE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH ITRACONAZOLE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) CARBAMAZEPINE SIGNIFICANT INTERACTION WITH PROPOXYPHENE CARBAMAZEPINE SIGNIFICANT INTERACTION WITH VERAPAMIL CARBENICILLIN SIGNIFICANT INTERACTION WITH AMIKACIN CARBENICILLIN SIGNIFICANT INTERACTION WITH DEMECLOCYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN CARBENICILLIN SIGNIFICANT INTERACTION WITH MINOCYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH NETILMICIN CARBENICILLIN SIGNIFICANT INTERACTION WITH OXYTETRACYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH TETRACYCLINE CARBENICILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN CARTEOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE

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CARTEOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE CARTEOLOL SIGNIFICANT INTERACTION WITH CLONIDINE CARTEOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE CARTEOLOL SIGNIFICANT INTERACTION WITH FELODIPINE CARTEOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE CARTEOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE CARTEOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN CARTEOLOL SIGNIFICANT INTERACTION WITH INSULIN CARTEOLOL SIGNIFICANT INTERACTION WITH PIROXICAM CARTEOLOL SIGNIFICANT INTERACTION WITH SULINDAC CARTEOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE CARTEOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE CHLORAMPHENICOL SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM CHLORAMPHENICOL SIGNIFICANT INTERACTION WITH PHENYTOIN CHLORDIAZEPOXIDE SIGNIFICANT INTERACTION WITH CLOZAPINE CHLORDIAZEPOXIDE SIGNIFICANT INTERACTION WITH RITONAVIR CHLOROQUINE SIGNIFICANT INTERACTION WITH CYCLOSPORINE CHLOROQUINE SIGNIFICANT INTERACTION WITH PRAZIQUANTEL CHLOROTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS CHLORPROMAZINE SIGNIFICANT INTERACTION WITH MEPERIDINE CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH LABETALOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH NADOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH SOTALOL CHLORPROPAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL CHLORTHALIDONE SIGNIFICANT INTERACTION WITH DIGITALIS CHLORZOXAZONE SIGNIFICANT INTERACTION WITH DISULFIRAM CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH ANISINDIONE CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH DICUMAROL CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH DIGITALIS

April 1998 National Drug File V. 3.18 201 User Manual Appendix D

CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON CHOLESTYRAMINE SIGNIFICANT INTERACTION WITH WARFARIN CHOLINE SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN CIMETIDINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE CIMETIDINE SIGNIFICANT INTERACTION WITH CLOZAPINE CIMETIDINE SIGNIFICANT INTERACTION WITH ENOXACIN CIMETIDINE SIGNIFICANT INTERACTION WITH METOPROLOL CIMETIDINE SIGNIFICANT INTERACTION WITH PAROXETINE CIMETIDINE SIGNIFICANT INTERACTION WITH PROPRANOLOL CIMETIDINE SIGNIFICANT INTERACTION WITH TACRINE HYDROCHLORIDE CIMETIDINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH IRON CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE CIPROFLOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE CISAPRIDE SIGNIFICANT INTERACTION WITH ATROPINE CLARITHROMYCIN SIGNIFICANT INTERACTION WITH CARBAMAZEPINE CLARITHROMYCIN SIGNIFICANT INTERACTION WITH TACROLIMUS CLOMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE CLOMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE CLONAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE CLONAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR CLONIDINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL CLONIDINE SIGNIFICANT INTERACTION WITH ATENOLOL CLONIDINE SIGNIFICANT INTERACTION WITH BETAXOLOL CLONIDINE SIGNIFICANT INTERACTION WITH CARTEOLOL CLONIDINE SIGNIFICANT INTERACTION WITH METOPROLOL CLONIDINE SIGNIFICANT INTERACTION WITH NADOLOL

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CLONIDINE SIGNIFICANT INTERACTION WITH PENBUTOLOL CLONIDINE SIGNIFICANT INTERACTION WITH PINDOLOL CLONIDINE SIGNIFICANT INTERACTION WITH PROPRANOLOL CLONIDINE SIGNIFICANT INTERACTION WITH TIMOLOL CLORAZEPATE SIGNIFICANT INTERACTION WITH CLOZAPINE CLORAZEPATE SIGNIFICANT INTERACTION WITH RITONAVIR CLOZAPINE SIGNIFICANT INTERACTION WITH ALPRAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH CHLORDIAZEPOXIDE CLOZAPINE SIGNIFICANT INTERACTION WITH CIMETIDINE CLOZAPINE SIGNIFICANT INTERACTION WITH CLONAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH CLORAZEPATE CLOZAPINE SIGNIFICANT INTERACTION WITH DIAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH ERYTHROMYCIN CLOZAPINE SIGNIFICANT INTERACTION WITH ESTAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH FLURAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE CLOZAPINE SIGNIFICANT INTERACTION WITH HALAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH LORAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH MEPERIDINE CLOZAPINE SIGNIFICANT INTERACTION WITH MIDAZOLAM CLOZAPINE SIGNIFICANT INTERACTION WITH OXAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH PRAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH QUAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH RITONAVIR CLOZAPINE SIGNIFICANT INTERACTION WITH TEMAZEPAM CLOZAPINE SIGNIFICANT INTERACTION WITH TRIAZOLAM CORTICOTROPIN SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN COSYNTROPIN SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE CYCLOSPORINE SIGNIFICANT INTERACTION WITH CHLOROQUINE CYCLOSPORINE SIGNIFICANT INTERACTION WITH DANAZOL CYCLOSPORINE SIGNIFICANT INTERACTION WITH DIGITALIS CYCLOSPORINE SIGNIFICANT INTERACTION WITH IMIPENEM CYCLOSPORINE SIGNIFICANT INTERACTION WITH KETOCONAZOLE CYCLOSPORINE SIGNIFICANT INTERACTION WITH LOVASTATIN CYCLOSPORINE SIGNIFICANT INTERACTION WITH METOCLOPRAMIDE CYCLOSPORINE SIGNIFICANT INTERACTION WITH TACROLIMUS

April 1998 National Drug File V. 3.18 203 User Manual Appendix D

CYCLOSPORINE SIGNIFICANT INTERACTION WITH TICLOPIDINE CYCLOSPORINE SIGNIFICANT INTERACTION WITH TRIMETHOPRIM CYCLOTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS CYPROHEPTADINE SIGNIFICANT INTERACTION WITH FLUOXETINE CYPROHEPTADINE SIGNIFICANT INTERACTION WITH PAROXETINE DANAZOL SIGNIFICANT INTERACTION WITH CARBAMAZEPINE DANAZOL SIGNIFICANT INTERACTION WITH CYCLOSPORINE DANAZOL SIGNIFICANT INTERACTION WITH TACROLIMUS DEMECLOCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN DEMECLOCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS DESFLURANE SIGNIFICANT INTERACTION WITH LABETALOL DESIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE DESIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE DESOGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN DESOGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN DESOXYCORTICOSTERONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE DEXAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE DEXAMETHASONE SIGNIFICANT INTERACTION WITH RIFAMPIN DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PHENELZINE DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH SELEGILINE DEXFENFLURAMINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE DEXTROMETHORPHAN SIGNIFICANT INTERACTION WITH PAROXETINE DIAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE DIAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR DICLOFENAC SIGNIFICANT INTERACTION WITH ANISINDIONE DICLOFENAC SIGNIFICANT INTERACTION WITH DICUMAROL DICLOFENAC SIGNIFICANT INTERACTION WITH METHOTREXATE DICLOFENAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON DICLOFENAC SIGNIFICANT INTERACTION WITH WARFARIN DICUMAROL SIGNIFICANT INTERACTION WITH BUTABARBITAL DICUMAROL SIGNIFICANT INTERACTION WITH BUTALBITAL DICUMAROL SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE DICUMAROL SIGNIFICANT INTERACTION WITH DICLOFENAC DICUMAROL SIGNIFICANT INTERACTION WITH DIFLUNISAL DICUMAROL SIGNIFICANT INTERACTION WITH ERYTHROMYCIN DICUMAROL SIGNIFICANT INTERACTION WITH ETODOLAC DICUMAROL SIGNIFICANT INTERACTION WITH FENOPROFEN

204 National Drug File V. 3.18 April 1998 User Manual Significant Drug Interactions

DICUMAROL SIGNIFICANT INTERACTION WITH FLURBIPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH IBUPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH INDOMETHACIN DICUMAROL SIGNIFICANT INTERACTION WITH KETOPROFEN DICUMAROL SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE DICUMAROL SIGNIFICANT INTERACTION WITH LEVAMISOLE DICUMAROL SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM DICUMAROL SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID DICUMAROL SIGNIFICANT INTERACTION WITH MEFENAMIC ACID DICUMAROL SIGNIFICANT INTERACTION WITH METHIMAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH METRONIDAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH NABUMETONE DICUMAROL SIGNIFICANT INTERACTION WITH NAPROXEN DICUMAROL SIGNIFICANT INTERACTION WITH OXAPROZIN DICUMAROL SIGNIFICANT INTERACTION WITH PAROXETINE DICUMAROL SIGNIFICANT INTERACTION WITH PHENYTOIN DICUMAROL SIGNIFICANT INTERACTION WITH PHYTONADIONE DICUMAROL SIGNIFICANT INTERACTION WITH PIROXICAM DICUMAROL SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL DICUMAROL SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH SULFINPYRAZONE DICUMAROL SIGNIFICANT INTERACTION WITH SULFISOXAZOLE DICUMAROL SIGNIFICANT INTERACTION WITH SULINDAC DICUMAROL SIGNIFICANT INTERACTION WITH THYROGLOBULIN DICUMAROL SIGNIFICANT INTERACTION WITH THYROID DICUMAROL SIGNIFICANT INTERACTION WITH TOLMETIN DICUMAROL SIGNIFICANT INTERACTION WITH VITAMIN E DICUMAROL SIGNIFICANT INTERACTION WITH VITAMIN K DIDANOSINE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH ENOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH GANCICLOVIR DIDANOSINE SIGNIFICANT INTERACTION WITH ITRACONAZOLE DIDANOSINE SIGNIFICANT INTERACTION WITH KETOCONAZOLE DIDANOSINE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH NORFLOXACIN

April 1998 National Drug File V. 3.18 205 User Manual Appendix D

DIDANOSINE SIGNIFICANT INTERACTION WITH OFLOXACIN DIDANOSINE SIGNIFICANT INTERACTION WITH TETRACYCLINE DIDANOSINE SIGNIFICANT INTERACTION WITH ZALCITABINE (DIDEOXYCYTIDINE,ddC) DIFLUNISAL SIGNIFICANT INTERACTION WITH ANISINDIONE DIFLUNISAL SIGNIFICANT INTERACTION WITH DICUMAROL DIFLUNISAL SIGNIFICANT INTERACTION WITH PHENPROCOUMON DIFLUNISAL SIGNIFICANT INTERACTION WITH PROBENECID DIFLUNISAL SIGNIFICANT INTERACTION WITH WARFARIN DIGITALIS SIGNIFICANT INTERACTION WITH BENDROFLUMETHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH BENZTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH BUMETANIDE DIGITALIS SIGNIFICANT INTERACTION WITH CHLOROTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH CHLORTHALIDONE DIGITALIS SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE DIGITALIS SIGNIFICANT INTERACTION WITH CYCLOSPORINE DIGITALIS SIGNIFICANT INTERACTION WITH CYCLOTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH DEMECLOCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH DOXYCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID DIGITALIS SIGNIFICANT INTERACTION WITH FUROSEMIDE DIGITALIS SIGNIFICANT INTERACTION WITH HYDROCHLOROTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH HYDROFLUMETHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH INDAPAMIDE DIGITALIS SIGNIFICANT INTERACTION WITH METHYCLOTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH METOLAZONE DIGITALIS SIGNIFICANT INTERACTION WITH MINOCYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH OXYTETRACYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH POLYTHIAZIDE DIGITALIS SIGNIFICANT INTERACTION WITH PROPAFENONE DIGITALIS SIGNIFICANT INTERACTION WITH QUINETHAZONE DIGITALIS SIGNIFICANT INTERACTION WITH QUINIDINE DIGITALIS SIGNIFICANT INTERACTION WITH TETRACYCLINE DIGITALIS SIGNIFICANT INTERACTION WITH TRICHLORMETHIAZIDE DIHYDROXYALUMINUM SODIUM CARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN DIHYDROXYALUMINUM SODIUM CARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN DILTIAZEM SIGNIFICANT INTERACTION WITH THEOPHYLLINE DISULFIRAM SIGNIFICANT INTERACTION WITH CHLORZOXAZONE DISULFIRAM SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM

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DISULFIRAM SIGNIFICANT INTERACTION WITH PHENYTOIN DOXEPIN SIGNIFICANT INTERACTION WITH FLUOXETINE DOXEPIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN DOXYCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS DOXYCYCLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGALDRATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE DOXYCYCLINE SIGNIFICANT INTERACTION WITH PHENYTOIN DOXYCYCLINE SIGNIFICANT INTERACTION WITH RIFAMPIN EDROPHONIUM SIGNIFICANT INTERACTION WITH BETAMETHASONE ENALAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE ENALAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN ENALAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE ENALAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE ENCAINIDE SIGNIFICANT INTERACTION WITH RITONAVIR ENFLURANE SIGNIFICANT INTERACTION WITH ISONIAZID ENFLURANE SIGNIFICANT INTERACTION WITH LABETALOL ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE ENOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE ENOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH CIMETIDINE ENOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE ENOXACIN SIGNIFICANT INTERACTION WITH DIHYDROXYALUMINUM SODIUM CARBONATE ENOXACIN SIGNIFICANT INTERACTION WITH FAMOTIDINE ENOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE ENOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE ENOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE ENOXACIN SIGNIFICANT INTERACTION WITH NIZATIDINE ENOXACIN SIGNIFICANT INTERACTION WITH RANITIDINE ENOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE

April 1998 National Drug File V. 3.18 207 User Manual Appendix D

ENOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE EPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE EPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM ACETATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM CITRATE EPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM LACTATE EPHEDRINE SIGNIFICANT INTERACTION WITH TROMETHAMINE EPINEPHRINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH ATENOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH BETAXOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE EPINEPHRINE SIGNIFICANT INTERACTION WITH CARTEOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH LABETALOL EPINEPHRINE SIGNIFICANT INTERACTION WITH METOPROLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH NADOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PENBUTOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PINDOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH PROPRANOLOL EPINEPHRINE SIGNIFICANT INTERACTION WITH SOTALOL EPINEPHRINE SIGNIFICANT INTERACTION WITH TIMOLOL ERYTHROMYCIN SIGNIFICANT INTERACTION WITH ALFENTANIL ERYTHROMYCIN SIGNIFICANT INTERACTION WITH ANISINDIONE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH BROMOCRIPTINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH CARBAMAZEPINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH CLOZAPINE ERYTHROMYCIN SIGNIFICANT INTERACTION WITH DICUMAROL ERYTHROMYCIN SIGNIFICANT INTERACTION WITH MIDAZOLAM ERYTHROMYCIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON ERYTHROMYCIN SIGNIFICANT INTERACTION WITH TACROLIMUS ERYTHROMYCIN SIGNIFICANT INTERACTION WITH TRIAZOLAM ERYTHROMYCIN SIGNIFICANT INTERACTION WITH WARFARIN ESMOLOL SIGNIFICANT INTERACTION WITH FELODIPINE ESTAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE ESTAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH AMIKACIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH BENAZEPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH DIGITALIS

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ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH FOSINOPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH GENTAMICIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH KANAMYCIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH NETILMICIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH QUINAPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH RAMIPRIL ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH STREPTOMYCIN ETHACRYNIC ACID SIGNIFICANT INTERACTION WITH TOBRAMYCIN ETHINYL ESTRADIOL SIGNIFICANT INTERACTION WITH RIFABUTIN ETHINYL ESTRADIOL SIGNIFICANT INTERACTION WITH RIFAMPIN ETHOTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE ETHOTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE ETHYNODIOL DIACETATE SIGNIFICANT INTERACTION WITH RIFABUTIN ETHYNODIOL DIACETATE SIGNIFICANT INTERACTION WITH RIFAMPIN ETODOLAC SIGNIFICANT INTERACTION WITH ANISINDIONE ETODOLAC SIGNIFICANT INTERACTION WITH DICUMAROL ETODOLAC SIGNIFICANT INTERACTION WITH METHOTREXATE ETODOLAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON ETODOLAC SIGNIFICANT INTERACTION WITH WARFARIN FAMOTIDINE SIGNIFICANT INTERACTION WITH ENOXACIN FELBAMATE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE FELBAMATE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FELBAMATE SIGNIFICANT INTERACTION WITH PHENYTOIN FELODIPINE SIGNIFICANT INTERACTION WITH ACEBUTOLOL FELODIPINE SIGNIFICANT INTERACTION WITH ATENOLOL FELODIPINE SIGNIFICANT INTERACTION WITH BETAXOLOL FELODIPINE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE FELODIPINE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE FELODIPINE SIGNIFICANT INTERACTION WITH CARTEOLOL FELODIPINE SIGNIFICANT INTERACTION WITH ESMOLOL FELODIPINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FELODIPINE SIGNIFICANT INTERACTION WITH LABETALOL FELODIPINE SIGNIFICANT INTERACTION WITH METOPROLOL FELODIPINE SIGNIFICANT INTERACTION WITH NADOLOL FELODIPINE SIGNIFICANT INTERACTION WITH PENBUTOLOL FELODIPINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL FELODIPINE SIGNIFICANT INTERACTION WITH PHENYTOIN FELODIPINE SIGNIFICANT INTERACTION WITH PINDOLOL

April 1998 National Drug File V. 3.18 209 User Manual Appendix D

FELODIPINE SIGNIFICANT INTERACTION WITH PROPRANOLOL FELODIPINE SIGNIFICANT INTERACTION WITH SOTALOL FELODIPINE SIGNIFICANT INTERACTION WITH TIMOLOL FENFLURAMINE SIGNIFICANT INTERACTION WITH SELEGILINE FENOPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE FENOPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL FENOPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE FENOPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON FENOPROFEN SIGNIFICANT INTERACTION WITH WARFARIN FERROUS FUMARATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS FUMARATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS FUMARATE SIGNIFICANT INTERACTION WITH OFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS GLUCONATE SIGNIFICANT INTERACTION WITH OFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH NORFLOXACIN FERROUS SULFATE SIGNIFICANT INTERACTION WITH OFLOXACIN FLUCONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM FLUDROCORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE FLUDROCORTISONE SIGNIFICANT INTERACTION WITH RIFABUTIN FLUDROCORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN FLUOXETINE SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FLUOXETINE SIGNIFICANT INTERACTION WITH AMITRIPTYLINE FLUOXETINE SIGNIFICANT INTERACTION WITH AMOXAPINE FLUOXETINE SIGNIFICANT INTERACTION WITH CLOMIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH CYPROHEPTADINE FLUOXETINE SIGNIFICANT INTERACTION WITH DESIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH DOXEPIN FLUOXETINE SIGNIFICANT INTERACTION WITH ETHOTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FLUOXETINE SIGNIFICANT INTERACTION WITH IMIPRAMINE FLUOXETINE SIGNIFICANT INTERACTION WITH MEPHENYTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH NORTRIPTYLINE FLUOXETINE SIGNIFICANT INTERACTION WITH PHENYTOIN FLUOXETINE SIGNIFICANT INTERACTION WITH PROTRIPTYLINE

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FLUOXETINE SIGNIFICANT INTERACTION WITH THEOPHYLLINE FLUOXETINE SIGNIFICANT INTERACTION WITH TRIMIPRAMINE FLUOXYMESTERONE SIGNIFICANT INTERACTION WITH WARFARIN FLURAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE FLURAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR FLURBIPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE FLURBIPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL FLURBIPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE FLURBIPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON FLURBIPROFEN SIGNIFICANT INTERACTION WITH WARFARIN FLUVASTATIN SODIUM SIGNIFICANT INTERACTION WITH GEMFIBROZIL FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMITRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH AMOXAPINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH CLOMIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH CLOZAPINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH DESIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH DOXEPIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH ETHOTOIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH IMIPRAMINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH MEPHENYTOIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH NORTRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH PHENYTOIN FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH PROTRIPTYLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH THEOPHYLLINE FLUVOXAMINE MALEATE SIGNIFICANT INTERACTION WITH TRIMIPRAMINE FOSCARNET SIGNIFICANT INTERACTION WITH PENTAMIDINE FOSINOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID FOSINOPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN FOSINOPRIL SIGNIFICANT INTERACTION WITH LITHIUM FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE

April 1998 National Drug File V. 3.18 211 User Manual Appendix D

FOSINOPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE FOSINOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE FOSINOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH AMINOPHYLLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH CHLORAMPHENICOL FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DISULFIRAM FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH DOXYCYCLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FELBAMATE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FELODIPINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FLUOXETINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH ITRACONAZOLE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH TENIPOSIDE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH THEOPHYLLINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH TICLOPIDINE FOSPHENYTOIN SODIUM SIGNIFICANT INTERACTION WITH WARFARIN FUROSEMIDE SIGNIFICANT INTERACTION WITH AMIKACIN FUROSEMIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH DIGITALIS FUROSEMIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH GENTAMICIN FUROSEMIDE SIGNIFICANT INTERACTION WITH KANAMYCIN FUROSEMIDE SIGNIFICANT INTERACTION WITH NETILMICIN FUROSEMIDE SIGNIFICANT INTERACTION WITH QUINAPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH RAMIPRIL FUROSEMIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN FUROSEMIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH AMIKACIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH GENTAMICIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH KANAMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH NEOMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH NETILMICIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH STREPTOMYCIN GALLAMINE TRIETHIODIDE SIGNIFICANT INTERACTION WITH TOBRAMYCIN GANCICLOVIR SIGNIFICANT INTERACTION WITH DIDANOSINE

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GEMFIBROZIL SIGNIFICANT INTERACTION WITH FLUVASTATIN SODIUM GEMFIBROZIL SIGNIFICANT INTERACTION WITH PRAVASTATIN GEMFIBROZIL SIGNIFICANT INTERACTION WITH SIMVASTATIN GENTAMICIN SIGNIFICANT INTERACTION WITH AMPICILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH ATRACURIUM GENTAMICIN SIGNIFICANT INTERACTION WITH BUMETANIDE GENTAMICIN SIGNIFICANT INTERACTION WITH CARBENICILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID GENTAMICIN SIGNIFICANT INTERACTION WITH FUROSEMIDE GENTAMICIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE GENTAMICIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE GENTAMICIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH PANCURONIUM GENTAMICIN SIGNIFICANT INTERACTION WITH PIPERACILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH TICARCILLIN GENTAMICIN SIGNIFICANT INTERACTION WITH TORSEMIDE GENTAMICIN SIGNIFICANT INTERACTION WITH TUBOCURARINE GENTAMICIN SIGNIFICANT INTERACTION WITH VANCOMYCIN GENTAMICIN SIGNIFICANT INTERACTION WITH VECURONIUM GLIPIZIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH ATENOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH BETAXOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE GLIPIZIDE SIGNIFICANT INTERACTION WITH CARTEOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH LABETALOL GLIPIZIDE SIGNIFICANT INTERACTION WITH METOPROLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH NADOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PINDOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL GLIPIZIDE SIGNIFICANT INTERACTION WITH SOTALOL GLIPIZIDE SIGNIFICANT INTERACTION WITH TIMOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH ATENOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH BETAXOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE GLYBURIDE SIGNIFICANT INTERACTION WITH CARTEOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH LABETALOL

April 1998 National Drug File V. 3.18 213 User Manual Appendix D

GLYBURIDE SIGNIFICANT INTERACTION WITH METOPROLOL GLYBURIDE SIGNIFICANT INTERACTION WITH NADOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PINDOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL GLYBURIDE SIGNIFICANT INTERACTION WITH SOTALOL GLYBURIDE SIGNIFICANT INTERACTION WITH TIMOLOL HALAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE HALAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR HALOPERIDOL SIGNIFICANT INTERACTION WITH LITHIUM HALOPERIDOL SIGNIFICANT INTERACTION WITH RIFAMPIN HALOPERIDOL SIGNIFICANT INTERACTION WITH TACRINE HYDROCHLORIDE HALOTHANE SIGNIFICANT INTERACTION WITH LABETALOL HEPARIN SIGNIFICANT INTERACTION WITH ASPIRIN HEPARIN SIGNIFICANT INTERACTION WITH BISMUTH SUBSALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH CHOLINE SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH MAGNESIUM SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH SALSALATE HEPARIN SIGNIFICANT INTERACTION WITH SODIUM SALICYLATE HEPARIN SIGNIFICANT INTERACTION WITH SODIUM THIOSALICYLATE HYDROCHLOROTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS HYDROCORTISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE HYDROCORTISONE SIGNIFICANT INTERACTION WITH NEOSTIGMINE HYDROCORTISONE SIGNIFICANT INTERACTION WITH PYRIDOSTIGMINE HYDROCORTISONE SIGNIFICANT INTERACTION WITH RIFABUTIN HYDROCORTISONE SIGNIFICANT INTERACTION WITH RIFAMPIN HYDROFLUMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS IBUPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE IBUPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL IBUPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE IBUPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON IBUPROFEN SIGNIFICANT INTERACTION WITH WARFARIN IMIPENEM SIGNIFICANT INTERACTION WITH CYCLOSPORINE IMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE IMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE INDAPAMIDE SIGNIFICANT INTERACTION WITH DIGITALIS INDINAVIR SULFATE SIGNIFICANT INTERACTION WITH MIDAZOLAM INDINAVIR SULFATE SIGNIFICANT INTERACTION WITH TRIAZOLAM

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INDOMETHACIN SIGNIFICANT INTERACTION WITH ACEBUTOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH ANISINDIONE INDOMETHACIN SIGNIFICANT INTERACTION WITH ATENOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH BENAZEPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH BETAXOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE INDOMETHACIN SIGNIFICANT INTERACTION WITH CAPTOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH CARTEOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH DICUMAROL INDOMETHACIN SIGNIFICANT INTERACTION WITH ENALAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH FOSINOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH LABETALOL INDOMETHACIN SIGNIFICANT INTERACTION WITH LISINOPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH METHOTREXATE INDOMETHACIN SIGNIFICANT INTERACTION WITH METOPROLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH NADOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PENBUTOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON INDOMETHACIN SIGNIFICANT INTERACTION WITH PINDOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH PROPRANOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH QUINAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH RAMIPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH SOTALOL INDOMETHACIN SIGNIFICANT INTERACTION WITH TIMOLOL INDOMETHACIN SIGNIFICANT INTERACTION WITH TRANDOLAPRIL INDOMETHACIN SIGNIFICANT INTERACTION WITH WARFARIN INSULIN SIGNIFICANT INTERACTION WITH ACEBUTOLOL INSULIN SIGNIFICANT INTERACTION WITH ATENOLOL INSULIN SIGNIFICANT INTERACTION WITH BETAXOLOL INSULIN SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE INSULIN SIGNIFICANT INTERACTION WITH CARTEOLOL INSULIN SIGNIFICANT INTERACTION WITH LABETALOL INSULIN SIGNIFICANT INTERACTION WITH METOPROLOL INSULIN SIGNIFICANT INTERACTION WITH NADOLOL INSULIN SIGNIFICANT INTERACTION WITH PENBUTOLOL INSULIN SIGNIFICANT INTERACTION WITH PINDOLOL INSULIN SIGNIFICANT INTERACTION WITH PROPRANOLOL INSULIN SIGNIFICANT INTERACTION WITH SOTALOL

April 1998 National Drug File V. 3.18 215 User Manual Appendix D

INSULIN SIGNIFICANT INTERACTION WITH TIMOLOL IRON SIGNIFICANT INTERACTION WITH CIPROFLOXACIN IRON SIGNIFICANT INTERACTION WITH LOMEFLOXACIN IRON SIGNIFICANT INTERACTION WITH NORFLOXACIN IRON SIGNIFICANT INTERACTION WITH OFLOXACIN ISOCARBOXAZID SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH MAZINDOL ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENDIMETRAZINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENMETRAZINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH PHENTERMINE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH SUMATRIPTAN ISOCARBOXAZID SIGNIFICANT INTERACTION WITH SUMATRIPTAN SUCCINATE ISOCARBOXAZID SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE ISOFLURANE SIGNIFICANT INTERACTION WITH LABETALOL ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH BROMOCRIPTINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH PARGYLINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH PHENELZINE ISOMETHEPTENE MUCATE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE ISONIAZID SIGNIFICANT INTERACTION WITH ENFLURANE ITRACONAZOLE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE ITRACONAZOLE SIGNIFICANT INTERACTION WITH DIDANOSINE ITRACONAZOLE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM ITRACONAZOLE SIGNIFICANT INTERACTION WITH MEPHENYTOIN ITRACONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM ITRACONAZOLE SIGNIFICANT INTERACTION WITH PHENYTOIN ITRACONAZOLE SIGNIFICANT INTERACTION WITH TRIAZOLAM KANAMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE KANAMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID KANAMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE KANAMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE KANAMYCIN SIGNIFICANT INTERACTION WITH METOCURINE IODIDE KANAMYCIN SIGNIFICANT INTERACTION WITH PANCURONIUM KANAMYCIN SIGNIFICANT INTERACTION WITH TORSEMIDE KANAMYCIN SIGNIFICANT INTERACTION WITH TUBOCURARINE KANAMYCIN SIGNIFICANT INTERACTION WITH VECURONIUM KETOCONAZOLE SIGNIFICANT INTERACTION WITH CYCLOSPORINE

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KETOCONAZOLE SIGNIFICANT INTERACTION WITH DIDANOSINE KETOCONAZOLE SIGNIFICANT INTERACTION WITH MIDAZOLAM KETOCONAZOLE SIGNIFICANT INTERACTION WITH TRIAZOLAM KETOPROFEN SIGNIFICANT INTERACTION WITH ANISINDIONE KETOPROFEN SIGNIFICANT INTERACTION WITH DICUMAROL KETOPROFEN SIGNIFICANT INTERACTION WITH METHOTREXATE KETOPROFEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON KETOPROFEN SIGNIFICANT INTERACTION WITH WARFARIN KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH ANISINDIONE KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH DICUMAROL KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH METHOTREXATE KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON KETOROLAC TROMETHAMINE SIGNIFICANT INTERACTION WITH WARFARIN LABETALOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE LABETALOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE LABETALOL SIGNIFICANT INTERACTION WITH DESFLURANE LABETALOL SIGNIFICANT INTERACTION WITH ENFLURANE LABETALOL SIGNIFICANT INTERACTION WITH EPINEPHRINE LABETALOL SIGNIFICANT INTERACTION WITH FELODIPINE LABETALOL SIGNIFICANT INTERACTION WITH GLIPIZIDE LABETALOL SIGNIFICANT INTERACTION WITH GLYBURIDE LABETALOL SIGNIFICANT INTERACTION WITH HALOTHANE LABETALOL SIGNIFICANT INTERACTION WITH INDOMETHACIN LABETALOL SIGNIFICANT INTERACTION WITH INSULIN LABETALOL SIGNIFICANT INTERACTION WITH ISOFLURANE LABETALOL SIGNIFICANT INTERACTION WITH METHOXYFLURANE LABETALOL SIGNIFICANT INTERACTION WITH PIROXICAM LABETALOL SIGNIFICANT INTERACTION WITH SEVOFLURANE LABETALOL SIGNIFICANT INTERACTION WITH SULINDAC LABETALOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE LABETALOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE LEVAMISOLE SIGNIFICANT INTERACTION WITH ANISINDIONE LEVAMISOLE SIGNIFICANT INTERACTION WITH DICUMAROL LEVAMISOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON LEVAMISOLE SIGNIFICANT INTERACTION WITH WARFARIN LEVODOPA SIGNIFICANT INTERACTION WITH RISPERIDONE LEVONORGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN LEVONORGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN

April 1998 National Drug File V. 3.18 217 User Manual Appendix D

LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH SUCRALFATE LEVOTHYROXINE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON LIOTHYRONINE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN LISINOPRIL SIGNIFICANT INTERACTION WITH AMILORIDE LISINOPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN LISINOPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE LISINOPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE LITHIUM SIGNIFICANT INTERACTION WITH BENAZEPRIL LITHIUM SIGNIFICANT INTERACTION WITH FOSINOPRIL LITHIUM SIGNIFICANT INTERACTION WITH HALOPERIDOL LITHIUM SIGNIFICANT INTERACTION WITH QUINAPRIL LITHIUM SIGNIFICANT INTERACTION WITH RAMIPRIL LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH DIHYDROXYALUMINUM SODIUM CARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH IRON LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGALDRATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE LOMEFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE LORAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE LOVASTATIN SIGNIFICANT INTERACTION WITH CYCLOSPORINE MAGALDRATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGALDRATE SIGNIFICANT INTERACTION WITH ENOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGALDRATE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN

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MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM CARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH ENOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGNESIUM HYDROXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH DOXYCYCLINE MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH ENOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN MAGNESIUM OXIDE SIGNIFICANT INTERACTION WITH TETRACYCLINE MAGNESIUM SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN MAZINDOL SIGNIFICANT INTERACTION WITH ISOCARBOXAZID MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH ANISINDIONE MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH DICUMAROL MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH METHOTREXATE MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH PHENPROCOUMON MECLOFENAMATE SODIUM SIGNIFICANT INTERACTION WITH WARFARIN MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH ANISINDIONE MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH DICUMAROL MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH METHOTREXATE MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH PHENPROCOUMON MECLOFENAMIC ACID SIGNIFICANT INTERACTION WITH WARFARIN MEDROXYPROGESTERONE SIGNIFICANT INTERACTION WITH RIFABUTIN MEDROXYPROGESTERONE SIGNIFICANT INTERACTION WITH RIFAMPIN MEFENAMIC ACID SIGNIFICANT INTERACTION WITH ANISINDIONE MEFENAMIC ACID SIGNIFICANT INTERACTION WITH DICUMAROL MEFENAMIC ACID SIGNIFICANT INTERACTION WITH METHOTREXATE MEFENAMIC ACID SIGNIFICANT INTERACTION WITH PHENPROCOUMON MEFENAMIC ACID SIGNIFICANT INTERACTION WITH WARFARIN MEPERIDINE SIGNIFICANT INTERACTION WITH CHLORPROMAZINE MEPERIDINE SIGNIFICANT INTERACTION WITH CLOZAPINE MEPERIDINE SIGNIFICANT INTERACTION WITH RISPERIDONE MEPERIDINE SIGNIFICANT INTERACTION WITH THIORIDAZINE MEPHENYTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE MEPHENYTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE MEPHENYTOIN SIGNIFICANT INTERACTION WITH ITRACONAZOLE

April 1998 National Drug File V. 3.18 219 User Manual Appendix D

MESTRANOL SIGNIFICANT INTERACTION WITH RIFABUTIN MESTRANOL SIGNIFICANT INTERACTION WITH RIFAMPIN METHIMAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE METHIMAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL METHIMAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON METHIMAZOLE SIGNIFICANT INTERACTION WITH WARFARIN METHOTREXATE SIGNIFICANT INTERACTION WITH BISMUTH SUBSALICYLATE METHOTREXATE SIGNIFICANT INTERACTION WITH DICLOFENAC METHOTREXATE SIGNIFICANT INTERACTION WITH ETODOLAC METHOTREXATE SIGNIFICANT INTERACTION WITH FENOPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH FLURBIPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH IBUPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH INDOMETHACIN METHOTREXATE SIGNIFICANT INTERACTION WITH KETOPROFEN METHOTREXATE SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE METHOTREXATE SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM METHOTREXATE SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID METHOTREXATE SIGNIFICANT INTERACTION WITH MEFENAMIC ACID METHOTREXATE SIGNIFICANT INTERACTION WITH NABUMETONE METHOTREXATE SIGNIFICANT INTERACTION WITH NAPROXEN METHOTREXATE SIGNIFICANT INTERACTION WITH OXAPROZIN METHOTREXATE SIGNIFICANT INTERACTION WITH PHENYLBUTAZONE METHOTREXATE SIGNIFICANT INTERACTION WITH PIROXICAM METHOTREXATE SIGNIFICANT INTERACTION WITH PROBENECID METHOTREXATE SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE METHOTREXATE SIGNIFICANT INTERACTION WITH SULINDAC METHOTREXATE SIGNIFICANT INTERACTION WITH TOLMETIN METHOXYFLURANE SIGNIFICANT INTERACTION WITH LABETALOL METHYCLOTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS METHYLPREDNISOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE METOCLOPRAMIDE SIGNIFICANT INTERACTION WITH CYCLOSPORINE METOCURINE IODIDE SIGNIFICANT INTERACTION WITH AMIKACIN METOCURINE IODIDE SIGNIFICANT INTERACTION WITH GENTAMICIN METOCURINE IODIDE SIGNIFICANT INTERACTION WITH KANAMYCIN METOLAZONE SIGNIFICANT INTERACTION WITH DIGITALIS METOPROLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH CIMETIDINE

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METOPROLOL SIGNIFICANT INTERACTION WITH CLONIDINE METOPROLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE METOPROLOL SIGNIFICANT INTERACTION WITH FELODIPINE METOPROLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE METOPROLOL SIGNIFICANT INTERACTION WITH GLYBURIDE METOPROLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN METOPROLOL SIGNIFICANT INTERACTION WITH INSULIN METOPROLOL SIGNIFICANT INTERACTION WITH PIROXICAM METOPROLOL SIGNIFICANT INTERACTION WITH SULINDAC METOPROLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE METOPROLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE METRONIDAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE METRONIDAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL METRONIDAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON METRONIDAZOLE SIGNIFICANT INTERACTION WITH WARFARIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH AMIKACIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH NETILMICIN MEZLOCILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN MIDAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE MIDAZOLAM SIGNIFICANT INTERACTION WITH ERYTHROMYCIN MIDAZOLAM SIGNIFICANT INTERACTION WITH FLUCONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH INDINAVIR SULFATE MIDAZOLAM SIGNIFICANT INTERACTION WITH ITRACONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH KETOCONAZOLE MIDAZOLAM SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) MIDAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR MINOCYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN MINOCYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS NABUMETONE SIGNIFICANT INTERACTION WITH ANISINDIONE NABUMETONE SIGNIFICANT INTERACTION WITH DICUMAROL NABUMETONE SIGNIFICANT INTERACTION WITH METHOTREXATE NABUMETONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON NABUMETONE SIGNIFICANT INTERACTION WITH WARFARIN NADOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE NADOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE NADOLOL SIGNIFICANT INTERACTION WITH CLONIDINE NADOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE

April 1998 National Drug File V. 3.18 221 User Manual Appendix D

NADOLOL SIGNIFICANT INTERACTION WITH FELODIPINE NADOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE NADOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE NADOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN NADOLOL SIGNIFICANT INTERACTION WITH INSULIN NADOLOL SIGNIFICANT INTERACTION WITH PIROXICAM NADOLOL SIGNIFICANT INTERACTION WITH SULINDAC NADOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE NADOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE NAPROXEN SIGNIFICANT INTERACTION WITH ANISINDIONE NAPROXEN SIGNIFICANT INTERACTION WITH DICUMAROL NAPROXEN SIGNIFICANT INTERACTION WITH METHOTREXATE NAPROXEN SIGNIFICANT INTERACTION WITH PHENPROCOUMON NAPROXEN SIGNIFICANT INTERACTION WITH WARFARIN NEOMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM NEOMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE NEOSTIGMINE SIGNIFICANT INTERACTION WITH BETAMETHASONE NEOSTIGMINE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE NEOSTIGMINE SIGNIFICANT INTERACTION WITH HYDROCORTISONE NETILMICIN SIGNIFICANT INTERACTION WITH AMPICILLIN NETILMICIN SIGNIFICANT INTERACTION WITH ATRACURIUM NETILMICIN SIGNIFICANT INTERACTION WITH BUMETANIDE NETILMICIN SIGNIFICANT INTERACTION WITH CARBENICILLIN NETILMICIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID NETILMICIN SIGNIFICANT INTERACTION WITH FUROSEMIDE NETILMICIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE NETILMICIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN NETILMICIN SIGNIFICANT INTERACTION WITH PIPERACILLIN NETILMICIN SIGNIFICANT INTERACTION WITH TICARCILLIN NETILMICIN SIGNIFICANT INTERACTION WITH VANCOMYCIN NIZATIDINE SIGNIFICANT INTERACTION WITH ENOXACIN NORETHINDRONE SIGNIFICANT INTERACTION WITH RIFABUTIN NORETHINDRONE SIGNIFICANT INTERACTION WITH RIFAMPIN NORETHYNODREL SIGNIFICANT INTERACTION WITH RIFABUTIN NORETHYNODREL SIGNIFICANT INTERACTION WITH RIFAMPIN NORFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE

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NORFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE NORFLOXACIN SIGNIFICANT INTERACTION WITH IRON NORFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE NORGESTIMATE SIGNIFICANT INTERACTION WITH RIFABUTIN NORGESTIMATE SIGNIFICANT INTERACTION WITH RIFAMPIN NORGESTREL SIGNIFICANT INTERACTION WITH RIFABUTIN NORGESTREL SIGNIFICANT INTERACTION WITH RIFAMPIN NORTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE NORTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE OFLOXACIN SIGNIFICANT INTERACTION WITH DIDANOSINE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS FUMARATE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS GLUCONATE OFLOXACIN SIGNIFICANT INTERACTION WITH FERROUS SULFATE OFLOXACIN SIGNIFICANT INTERACTION WITH IRON OFLOXACIN SIGNIFICANT INTERACTION WITH SUCRALFATE OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH CARBAMAZEPINE OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH MIDAZOLAM OLEANDOMYCIN (AS TROLEANDOMYCIN) SIGNIFICANT INTERACTION WITH TRIAZOLAM OXAPROZIN SIGNIFICANT INTERACTION WITH ANISINDIONE OXAPROZIN SIGNIFICANT INTERACTION WITH DICUMAROL OXAPROZIN SIGNIFICANT INTERACTION WITH METHOTREXATE OXAPROZIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON OXAPROZIN SIGNIFICANT INTERACTION WITH WARFARIN OXAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE OXYTETRACYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN OXYTETRACYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS PANCURONIUM SIGNIFICANT INTERACTION WITH AMIKACIN PANCURONIUM SIGNIFICANT INTERACTION WITH GENTAMICIN PANCURONIUM SIGNIFICANT INTERACTION WITH KANAMYCIN PANCURONIUM SIGNIFICANT INTERACTION WITH TOBRAMYCIN PARAMETHASONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PARGYLINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE PARGYLINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE PAROXETINE SIGNIFICANT INTERACTION WITH ANISINDIONE PAROXETINE SIGNIFICANT INTERACTION WITH CIMETIDINE PAROXETINE SIGNIFICANT INTERACTION WITH CYPROHEPTADINE PAROXETINE SIGNIFICANT INTERACTION WITH DEXTROMETHORPHAN PAROXETINE SIGNIFICANT INTERACTION WITH DICUMAROL

April 1998 National Drug File V. 3.18 223 User Manual Appendix D

PAROXETINE SIGNIFICANT INTERACTION WITH PHENPROCOUMON PAROXETINE SIGNIFICANT INTERACTION WITH WARFARIN PENBUTOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PENBUTOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PENBUTOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PENBUTOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PENBUTOLOL SIGNIFICANT INTERACTION WITH INSULIN PENBUTOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PENBUTOLOL SIGNIFICANT INTERACTION WITH SULINDAC PENBUTOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PENBUTOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PENTAMIDINE SIGNIFICANT INTERACTION WITH FOSCARNET PHENDIMETRAZINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENELZINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE PHENELZINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE PHENELZINE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE PHENELZINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE PHENMETRAZINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENOBARBITAL SIGNIFICANT INTERACTION WITH AMINOPHYLLINE PHENOBARBITAL SIGNIFICANT INTERACTION WITH FELODIPINE PHENOBARBITAL SIGNIFICANT INTERACTION WITH TENIPOSIDE PHENOBARBITAL SIGNIFICANT INTERACTION WITH THEOPHYLLINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH DICLOFENAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH DIFLUNISAL PHENPROCOUMON SIGNIFICANT INTERACTION WITH ERYTHROMYCIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH ETODOLAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH FENOPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH FLURBIPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH IBUPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH INDOMETHACIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH KETOPROFEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE

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PHENPROCOUMON SIGNIFICANT INTERACTION WITH LEVAMISOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM PHENPROCOUMON SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID PHENPROCOUMON SIGNIFICANT INTERACTION WITH MEFENAMIC ACID PHENPROCOUMON SIGNIFICANT INTERACTION WITH METHIMAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH METRONIDAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH NABUMETONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH NAPROXEN PHENPROCOUMON SIGNIFICANT INTERACTION WITH OXAPROZIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH PAROXETINE PHENPROCOUMON SIGNIFICANT INTERACTION WITH PHENYTOIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH PHYTONADIONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH PIROXICAM PHENPROCOUMON SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFINPYRAZONE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULFISOXAZOLE PHENPROCOUMON SIGNIFICANT INTERACTION WITH SULINDAC PHENPROCOUMON SIGNIFICANT INTERACTION WITH THYROGLOBULIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH THYROID PHENPROCOUMON SIGNIFICANT INTERACTION WITH TOLMETIN PHENPROCOUMON SIGNIFICANT INTERACTION WITH VITAMIN E PHENPROCOUMON SIGNIFICANT INTERACTION WITH VITAMIN K PHENTERMINE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID PHENYLBUTAZONE SIGNIFICANT INTERACTION WITH METHOTREXATE PHENYLPROPANOLAMINE SIGNIFICANT INTERACTION WITH BROMOCRIPTINE PHENYTOIN SIGNIFICANT INTERACTION WITH AMINOPHYLLINE PHENYTOIN SIGNIFICANT INTERACTION WITH ANISINDIONE PHENYTOIN SIGNIFICANT INTERACTION WITH CHLORAMPHENICOL PHENYTOIN SIGNIFICANT INTERACTION WITH DICUMAROL PHENYTOIN SIGNIFICANT INTERACTION WITH DISULFIRAM PHENYTOIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE PHENYTOIN SIGNIFICANT INTERACTION WITH FELBAMATE PHENYTOIN SIGNIFICANT INTERACTION WITH FELODIPINE PHENYTOIN SIGNIFICANT INTERACTION WITH FLUOXETINE PHENYTOIN SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE

April 1998 National Drug File V. 3.18 225 User Manual Appendix D

PHENYTOIN SIGNIFICANT INTERACTION WITH ITRACONAZOLE PHENYTOIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON PHENYTOIN SIGNIFICANT INTERACTION WITH TENIPOSIDE PHENYTOIN SIGNIFICANT INTERACTION WITH THEOPHYLLINE PHENYTOIN SIGNIFICANT INTERACTION WITH TICLOPIDINE PHENYTOIN SIGNIFICANT INTERACTION WITH WARFARIN PHYTONADIONE SIGNIFICANT INTERACTION WITH ANISINDIONE PHYTONADIONE SIGNIFICANT INTERACTION WITH DICUMAROL PHYTONADIONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON PINDOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PINDOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PINDOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PINDOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PINDOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PINDOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PINDOLOL SIGNIFICANT INTERACTION WITH INSULIN PINDOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PINDOLOL SIGNIFICANT INTERACTION WITH SULINDAC PINDOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PINDOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PIPERACILLIN SIGNIFICANT INTERACTION WITH AMIKACIN PIPERACILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN PIPERACILLIN SIGNIFICANT INTERACTION WITH NETILMICIN PIPERACILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN PIROXICAM SIGNIFICANT INTERACTION WITH ACEBUTOLOL PIROXICAM SIGNIFICANT INTERACTION WITH ANISINDIONE PIROXICAM SIGNIFICANT INTERACTION WITH ATENOLOL PIROXICAM SIGNIFICANT INTERACTION WITH BETAXOLOL PIROXICAM SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE PIROXICAM SIGNIFICANT INTERACTION WITH CARTEOLOL PIROXICAM SIGNIFICANT INTERACTION WITH DICUMAROL PIROXICAM SIGNIFICANT INTERACTION WITH LABETALOL PIROXICAM SIGNIFICANT INTERACTION WITH METHOTREXATE PIROXICAM SIGNIFICANT INTERACTION WITH METOPROLOL PIROXICAM SIGNIFICANT INTERACTION WITH NADOLOL PIROXICAM SIGNIFICANT INTERACTION WITH PENBUTOLOL

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PIROXICAM SIGNIFICANT INTERACTION WITH PHENPROCOUMON PIROXICAM SIGNIFICANT INTERACTION WITH PINDOLOL PIROXICAM SIGNIFICANT INTERACTION WITH PROPRANOLOL PIROXICAM SIGNIFICANT INTERACTION WITH SOTALOL PIROXICAM SIGNIFICANT INTERACTION WITH TIMOLOL PIROXICAM SIGNIFICANT INTERACTION WITH WARFARIN POLYTHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM ACETATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH EPHEDRINE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM BICARBONATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM CHLORIDE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH EPHEDRINE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE

April 1998 National Drug File V. 3.18 227 User Manual Appendix D

POTASSIUM CITRATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH BENAZEPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH FOSINOPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH QUINAPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH RAMIPRIL POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH SPIRONOLACTONE POTASSIUM GLUCONATE SIGNIFICANT INTERACTION WITH TRIAMTERENE POTASSIUM IODIDE SIGNIFICANT INTERACTION WITH AMILORIDE POTASSIUM PHOSPHATE SIGNIFICANT INTERACTION WITH AMILORIDE PRAVASTATIN SIGNIFICANT INTERACTION WITH GEMFIBROZIL PRAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE PRAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR PRAZIQUANTEL SIGNIFICANT INTERACTION WITH CHLOROQUINE PREDNISOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PREDNISONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE PROBENECID SIGNIFICANT INTERACTION WITH DIFLUNISAL PROBENECID SIGNIFICANT INTERACTION WITH METHOTREXATE PROCAINAMIDE SIGNIFICANT INTERACTION WITH TRIMETHOPRIM PROPAFENONE SIGNIFICANT INTERACTION WITH DIGITALIS PROPOXYPHENE SIGNIFICANT INTERACTION WITH CARBAMAZEPINE PROPRANOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH CIMETIDINE PROPRANOLOL SIGNIFICANT INTERACTION WITH CLONIDINE PROPRANOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE PROPRANOLOL SIGNIFICANT INTERACTION WITH FELODIPINE PROPRANOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN PROPRANOLOL SIGNIFICANT INTERACTION WITH INSULIN PROPRANOLOL SIGNIFICANT INTERACTION WITH PIROXICAM PROPRANOLOL SIGNIFICANT INTERACTION WITH SULINDAC PROPRANOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE PROPRANOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH ANISINDIONE PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH DICUMAROL PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH PHENPROCOUMON

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PROPYLTHIOURACIL SIGNIFICANT INTERACTION WITH WARFARIN PROTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUOXETINE PROTRIPTYLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH PHENELZINE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM ACETATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM CITRATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH SODIUM LACTATE PSEUDOEPHEDRINE SIGNIFICANT INTERACTION WITH TROMETHAMINE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH BETAMETHASONE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH FLUDROCORTISONE PYRIDOSTIGMINE SIGNIFICANT INTERACTION WITH HYDROCORTISONE QUAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE QUAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR QUINAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE QUINAPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE QUINAPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID QUINAPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE QUINAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN QUINAPRIL SIGNIFICANT INTERACTION WITH LITHIUM QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE QUINAPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE QUINAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE QUINAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE QUINETHAZONE SIGNIFICANT INTERACTION WITH DIGITALIS QUINIDINE SIGNIFICANT INTERACTION WITH AMILORIDE QUINIDINE SIGNIFICANT INTERACTION WITH DIGITALIS QUINIDINE SIGNIFICANT INTERACTION WITH RIFABUTIN QUINIDINE SIGNIFICANT INTERACTION WITH RIFAMPIN RAMIPRIL SIGNIFICANT INTERACTION WITH AMILORIDE RAMIPRIL SIGNIFICANT INTERACTION WITH BUMETANIDE RAMIPRIL SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID RAMIPRIL SIGNIFICANT INTERACTION WITH FUROSEMIDE

April 1998 National Drug File V. 3.18 229 User Manual Appendix D

RAMIPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN RAMIPRIL SIGNIFICANT INTERACTION WITH LITHIUM RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE RAMIPRIL SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE RAMIPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE RAMIPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE RANITIDINE SIGNIFICANT INTERACTION WITH ENOXACIN RIFABUTIN SIGNIFICANT INTERACTION WITH BETAMETHASONE RIFABUTIN SIGNIFICANT INTERACTION WITH DESOGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH ETHINYL ESTRADIOL RIFABUTIN SIGNIFICANT INTERACTION WITH ETHYNODIOL DIACETATE RIFABUTIN SIGNIFICANT INTERACTION WITH FLUDROCORTISONE RIFABUTIN SIGNIFICANT INTERACTION WITH HYDROCORTISONE RIFABUTIN SIGNIFICANT INTERACTION WITH LEVONORGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH MEDROXYPROGESTERONE RIFABUTIN SIGNIFICANT INTERACTION WITH MESTRANOL RIFABUTIN SIGNIFICANT INTERACTION WITH NORETHINDRONE RIFABUTIN SIGNIFICANT INTERACTION WITH NORETHYNODREL RIFABUTIN SIGNIFICANT INTERACTION WITH NORGESTIMATE RIFABUTIN SIGNIFICANT INTERACTION WITH NORGESTREL RIFABUTIN SIGNIFICANT INTERACTION WITH QUINIDINE RIFABUTIN SIGNIFICANT INTERACTION WITH SAQUINAVIR RIFAMPIN SIGNIFICANT INTERACTION WITH AMINOPHYLLINE RIFAMPIN SIGNIFICANT INTERACTION WITH BETAMETHASONE RIFAMPIN SIGNIFICANT INTERACTION WITH CORTISONE RIFAMPIN SIGNIFICANT INTERACTION WITH DESOGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH DEXAMETHASONE RIFAMPIN SIGNIFICANT INTERACTION WITH DOXYCYCLINE RIFAMPIN SIGNIFICANT INTERACTION WITH ETHINYL ESTRADIOL RIFAMPIN SIGNIFICANT INTERACTION WITH ETHYNODIOL DIACETATE RIFAMPIN SIGNIFICANT INTERACTION WITH FLUDROCORTISONE RIFAMPIN SIGNIFICANT INTERACTION WITH HALOPERIDOL RIFAMPIN SIGNIFICANT INTERACTION WITH HYDROCORTISONE RIFAMPIN SIGNIFICANT INTERACTION WITH LEVONORGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH MEDROXYPROGESTERONE

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RIFAMPIN SIGNIFICANT INTERACTION WITH MESTRANOL RIFAMPIN SIGNIFICANT INTERACTION WITH NORETHINDRONE RIFAMPIN SIGNIFICANT INTERACTION WITH NORETHYNODREL RIFAMPIN SIGNIFICANT INTERACTION WITH NORGESTIMATE RIFAMPIN SIGNIFICANT INTERACTION WITH NORGESTREL RIFAMPIN SIGNIFICANT INTERACTION WITH QUINIDINE RIFAMPIN SIGNIFICANT INTERACTION WITH SAQUINAVIR RIFAMPIN SIGNIFICANT INTERACTION WITH TACROLIMUS RIFAMPIN SIGNIFICANT INTERACTION WITH THEOPHYLLINE RISPERIDONE SIGNIFICANT INTERACTION WITH LEVODOPA RISPERIDONE SIGNIFICANT INTERACTION WITH MEPERIDINE RITONAVIR SIGNIFICANT INTERACTION WITH ALPRAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH AMIODARONE RITONAVIR SIGNIFICANT INTERACTION WITH BEPRIDIL RITONAVIR SIGNIFICANT INTERACTION WITH CHLORDIAZEPOXIDE RITONAVIR SIGNIFICANT INTERACTION WITH CLONAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH CLORAZEPATE RITONAVIR SIGNIFICANT INTERACTION WITH CLOZAPINE RITONAVIR SIGNIFICANT INTERACTION WITH DIAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH ENCAINIDE RITONAVIR SIGNIFICANT INTERACTION WITH ESTAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH FLURAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH HALAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH MIDAZOLAM RITONAVIR SIGNIFICANT INTERACTION WITH PRAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH QUAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH TEMAZEPAM RITONAVIR SIGNIFICANT INTERACTION WITH TRIAZOLAM SALSALATE SIGNIFICANT INTERACTION WITH HEPARIN SAQUINAVIR SIGNIFICANT INTERACTION WITH RIFABUTIN SAQUINAVIR SIGNIFICANT INTERACTION WITH RIFAMPIN SELEGILINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE SELEGILINE SIGNIFICANT INTERACTION WITH FENFLURAMINE SELEGILINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE SEVOFLURANE SIGNIFICANT INTERACTION WITH LABETALOL SIMVASTATIN SIGNIFICANT INTERACTION WITH GEMFIBROZIL SODIUM ACETATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM ACETATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE

April 1998 National Drug File V. 3.18 231 User Manual Appendix D

SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH CIPROFLOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH ENOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM BICARBONATE SIGNIFICANT INTERACTION WITH TETRACYCLINE SODIUM CITRATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM CITRATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM LACTATE SIGNIFICANT INTERACTION WITH EPHEDRINE SODIUM LACTATE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE SODIUM SALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN SODIUM THIOSALICYLATE SIGNIFICANT INTERACTION WITH HEPARIN SOTALOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE SOTALOL SIGNIFICANT INTERACTION WITH ASTEMIZOLE SOTALOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE SOTALOL SIGNIFICANT INTERACTION WITH EPINEPHRINE SOTALOL SIGNIFICANT INTERACTION WITH FELODIPINE SOTALOL SIGNIFICANT INTERACTION WITH GLIPIZIDE SOTALOL SIGNIFICANT INTERACTION WITH GLYBURIDE SOTALOL SIGNIFICANT INTERACTION WITH INDOMETHACIN SOTALOL SIGNIFICANT INTERACTION WITH INSULIN SOTALOL SIGNIFICANT INTERACTION WITH PIROXICAM SOTALOL SIGNIFICANT INTERACTION WITH SULINDAC SOTALOL SIGNIFICANT INTERACTION WITH TERFENADINE SOTALOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE SOTALOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH BENAZEPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH CAPTOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH ENALAPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH FOSINOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH LISINOPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE SPIRONOLACTONE SIGNIFICANT INTERACTION WITH QUINAPRIL SPIRONOLACTONE SIGNIFICANT INTERACTION WITH RAMIPRIL

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SPIRONOLACTONE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL STREPTOMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM STREPTOMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE STREPTOMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID STREPTOMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE STREPTOMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE SUCRALFATE SIGNIFICANT INTERACTION WITH ENOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM SUCRALFATE SIGNIFICANT INTERACTION WITH LOMEFLOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH NORFLOXACIN SUCRALFATE SIGNIFICANT INTERACTION WITH OFLOXACIN SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH METHOTREXATE SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFAMETHOXAZOLE SIGNIFICANT INTERACTION WITH WARFARIN SULFINPYRAZONE SIGNIFICANT INTERACTION WITH ACETAMINOPHEN SULFINPYRAZONE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFINPYRAZONE SIGNIFICANT INTERACTION WITH DICUMAROL SULFINPYRAZONE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFINPYRAZONE SIGNIFICANT INTERACTION WITH WARFARIN SULFISOXAZOLE SIGNIFICANT INTERACTION WITH ANISINDIONE SULFISOXAZOLE SIGNIFICANT INTERACTION WITH DICUMAROL SULFISOXAZOLE SIGNIFICANT INTERACTION WITH PHENPROCOUMON SULFISOXAZOLE SIGNIFICANT INTERACTION WITH WARFARIN SULINDAC SIGNIFICANT INTERACTION WITH ACEBUTOLOL SULINDAC SIGNIFICANT INTERACTION WITH ANISINDIONE SULINDAC SIGNIFICANT INTERACTION WITH ATENOLOL SULINDAC SIGNIFICANT INTERACTION WITH BETAXOLOL SULINDAC SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE SULINDAC SIGNIFICANT INTERACTION WITH CARTEOLOL SULINDAC SIGNIFICANT INTERACTION WITH DICUMAROL SULINDAC SIGNIFICANT INTERACTION WITH LABETALOL SULINDAC SIGNIFICANT INTERACTION WITH METHOTREXATE SULINDAC SIGNIFICANT INTERACTION WITH METOPROLOL SULINDAC SIGNIFICANT INTERACTION WITH NADOLOL SULINDAC SIGNIFICANT INTERACTION WITH PENBUTOLOL SULINDAC SIGNIFICANT INTERACTION WITH PHENPROCOUMON

April 1998 National Drug File V. 3.18 233 User Manual Appendix D

SULINDAC SIGNIFICANT INTERACTION WITH PINDOLOL SULINDAC SIGNIFICANT INTERACTION WITH PROPRANOLOL SULINDAC SIGNIFICANT INTERACTION WITH SOTALOL SULINDAC SIGNIFICANT INTERACTION WITH TIMOLOL SULINDAC SIGNIFICANT INTERACTION WITH WARFARIN SUMATRIPTAN SIGNIFICANT INTERACTION WITH ISOCARBOXAZID SUMATRIPTAN SUCCINATE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID TACRINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH CIMETIDINE TACRINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH HALOPERIDOL TACROLIMUS SIGNIFICANT INTERACTION WITH CLARITHROMYCIN TACROLIMUS SIGNIFICANT INTERACTION WITH CYCLOSPORINE TACROLIMUS SIGNIFICANT INTERACTION WITH DANAZOL TACROLIMUS SIGNIFICANT INTERACTION WITH ERYTHROMYCIN TACROLIMUS SIGNIFICANT INTERACTION WITH RIFAMPIN TEMAZEPAM SIGNIFICANT INTERACTION WITH CLOZAPINE TEMAZEPAM SIGNIFICANT INTERACTION WITH RITONAVIR TENIPOSIDE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM TENIPOSIDE SIGNIFICANT INTERACTION WITH PHENOBARBITAL TENIPOSIDE SIGNIFICANT INTERACTION WITH PHENYTOIN TERFENADINE SIGNIFICANT INTERACTION WITH SOTALOL TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM HYDROXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH ALUMINUM PHOSPHATE TETRACYCLINE SIGNIFICANT INTERACTION WITH CALCIUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH CARBENICILLIN TETRACYCLINE SIGNIFICANT INTERACTION WITH DIDANOSINE TETRACYCLINE SIGNIFICANT INTERACTION WITH DIGITALIS TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGALDRATE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM CARBONATE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM HYDROXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH MAGNESIUM OXIDE TETRACYCLINE SIGNIFICANT INTERACTION WITH SODIUM BICARBONATE THEOPHYLLINE SIGNIFICANT INTERACTION WITH DILTIAZEM THEOPHYLLINE SIGNIFICANT INTERACTION WITH FLUOXETINE THEOPHYLLINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE THEOPHYLLINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM THEOPHYLLINE SIGNIFICANT INTERACTION WITH PHENOBARBITAL THEOPHYLLINE SIGNIFICANT INTERACTION WITH PHENYTOIN

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THEOPHYLLINE SIGNIFICANT INTERACTION WITH RIFAMPIN THEOPHYLLINE SIGNIFICANT INTERACTION WITH TICLOPIDINE THEOPHYLLINE SIGNIFICANT INTERACTION WITH VERAPAMIL THIORIDAZINE SIGNIFICANT INTERACTION WITH MEPERIDINE THYROGLOBULIN SIGNIFICANT INTERACTION WITH ANISINDIONE THYROGLOBULIN SIGNIFICANT INTERACTION WITH DICUMAROL THYROGLOBULIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON THYROGLOBULIN SIGNIFICANT INTERACTION WITH WARFARIN THYROID SIGNIFICANT INTERACTION WITH ANISINDIONE THYROID SIGNIFICANT INTERACTION WITH DICUMAROL THYROID SIGNIFICANT INTERACTION WITH PHENPROCOUMON THYROID SIGNIFICANT INTERACTION WITH WARFARIN THYROID SIGNIFICANT INTERACTION WITH WARFARIN TICARCILLIN SIGNIFICANT INTERACTION WITH AMIKACIN TICARCILLIN SIGNIFICANT INTERACTION WITH GENTAMICIN TICARCILLIN SIGNIFICANT INTERACTION WITH NETILMICIN TICARCILLIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN TICLOPIDINE SIGNIFICANT INTERACTION WITH CYCLOSPORINE TICLOPIDINE SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM TICLOPIDINE SIGNIFICANT INTERACTION WITH PHENYTOIN TICLOPIDINE SIGNIFICANT INTERACTION WITH THEOPHYLLINE TIMOLOL SIGNIFICANT INTERACTION WITH ACETOHEXAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH CHLORPROPAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH CLONIDINE TIMOLOL SIGNIFICANT INTERACTION WITH EPINEPHRINE TIMOLOL SIGNIFICANT INTERACTION WITH FELODIPINE TIMOLOL SIGNIFICANT INTERACTION WITH GLIPIZIDE TIMOLOL SIGNIFICANT INTERACTION WITH GLYBURIDE TIMOLOL SIGNIFICANT INTERACTION WITH INDOMETHACIN TIMOLOL SIGNIFICANT INTERACTION WITH INSULIN TIMOLOL SIGNIFICANT INTERACTION WITH PIROXICAM TIMOLOL SIGNIFICANT INTERACTION WITH SULINDAC TIMOLOL SIGNIFICANT INTERACTION WITH TOLAZAMIDE TIMOLOL SIGNIFICANT INTERACTION WITH TOLBUTAMIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH AMPICILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH ATRACURIUM TOBRAMYCIN SIGNIFICANT INTERACTION WITH BUMETANIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH CARBENICILLIN

April 1998 National Drug File V. 3.18 235 User Manual Appendix D

TOBRAMYCIN SIGNIFICANT INTERACTION WITH ETHACRYNIC ACID TOBRAMYCIN SIGNIFICANT INTERACTION WITH FUROSEMIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH GALLAMINE TRIETHIODIDE TOBRAMYCIN SIGNIFICANT INTERACTION WITH MEZLOCILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH PANCURONIUM TOBRAMYCIN SIGNIFICANT INTERACTION WITH PIPERACILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH TICARCILLIN TOBRAMYCIN SIGNIFICANT INTERACTION WITH TUBOCURARINE TOBRAMYCIN SIGNIFICANT INTERACTION WITH VANCOMYCIN TOLAZAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE TOLAZAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH LABETALOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH NADOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH SOTALOL TOLAZAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH ACEBUTOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH ATENOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH BETAXOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH BISOPROLOL FUMARATE TOLBUTAMIDE SIGNIFICANT INTERACTION WITH CARTEOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH LABETALOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH METOPROLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH NADOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PENBUTOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PINDOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH PROPRANOLOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH SOTALOL TOLBUTAMIDE SIGNIFICANT INTERACTION WITH TIMOLOL TOLMETIN SIGNIFICANT INTERACTION WITH ANISINDIONE TOLMETIN SIGNIFICANT INTERACTION WITH DICUMAROL TOLMETIN SIGNIFICANT INTERACTION WITH METHOTREXATE

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TOLMETIN SIGNIFICANT INTERACTION WITH PHENPROCOUMON TOLMETIN SIGNIFICANT INTERACTION WITH WARFARIN TORSEMIDE SIGNIFICANT INTERACTION WITH AMIKACIN TORSEMIDE SIGNIFICANT INTERACTION WITH GENTAMICIN TORSEMIDE SIGNIFICANT INTERACTION WITH KANAMYCIN TRANDOLAPRIL SIGNIFICANT INTERACTION WITH AMILORIDE TRANDOLAPRIL SIGNIFICANT INTERACTION WITH INDOMETHACIN TRANDOLAPRIL SIGNIFICANT INTERACTION WITH SPIRONOLACTONE TRANDOLAPRIL SIGNIFICANT INTERACTION WITH TRIAMTERENE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH DEXFENFLURAMINE HYDROCHLORIDE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH ISOMETHEPTENE MUCATE TRANYLCYPROMINE SIGNIFICANT INTERACTION WITH VENLAFAXINE HYDROCHLORIDE TRIAMCINOLONE SIGNIFICANT INTERACTION WITH AMBENONIUM CHLORIDE TRIAMTERENE SIGNIFICANT INTERACTION WITH BENAZEPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH CAPTOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH ENALAPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH FOSINOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH LISINOPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM ACETATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM BICARBONATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM CHLORIDE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM CITRATE TRIAMTERENE SIGNIFICANT INTERACTION WITH POTASSIUM GLUCONATE TRIAMTERENE SIGNIFICANT INTERACTION WITH QUINAPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH RAMIPRIL TRIAMTERENE SIGNIFICANT INTERACTION WITH TRANDOLAPRIL TRIAZOLAM SIGNIFICANT INTERACTION WITH CLOZAPINE TRIAZOLAM SIGNIFICANT INTERACTION WITH ERYTHROMYCIN TRIAZOLAM SIGNIFICANT INTERACTION WITH INDINAVIR SULFATE TRIAZOLAM SIGNIFICANT INTERACTION WITH ITRACONAZOLE TRIAZOLAM SIGNIFICANT INTERACTION WITH KETOCONAZOLE TRIAZOLAM SIGNIFICANT INTERACTION WITH OLEANDOMYCIN (AS TROLEANDOMYCIN) TRIAZOLAM SIGNIFICANT INTERACTION WITH RITONAVIR TRICHLORMETHIAZIDE SIGNIFICANT INTERACTION WITH DIGITALIS TRIMETHOPRIM SIGNIFICANT INTERACTION WITH CYCLOSPORINE TRIMETHOPRIM SIGNIFICANT INTERACTION WITH PROCAINAMIDE TRIMIPRAMINE SIGNIFICANT INTERACTION WITH FLUOXETINE TRIMIPRAMINE SIGNIFICANT INTERACTION WITH FLUVOXAMINE MALEATE

April 1998 National Drug File V. 3.18 237 User Manual Appendix D

TROMETHAMINE SIGNIFICANT INTERACTION WITH EPHEDRINE TROMETHAMINE SIGNIFICANT INTERACTION WITH PSEUDOEPHEDRINE TUBOCURARINE SIGNIFICANT INTERACTION WITH AMIKACIN TUBOCURARINE SIGNIFICANT INTERACTION WITH GENTAMICIN TUBOCURARINE SIGNIFICANT INTERACTION WITH KANAMYCIN TUBOCURARINE SIGNIFICANT INTERACTION WITH TOBRAMYCIN VANCOMYCIN SIGNIFICANT INTERACTION WITH AMIKACIN VANCOMYCIN SIGNIFICANT INTERACTION WITH GENTAMICIN VANCOMYCIN SIGNIFICANT INTERACTION WITH NETILMICIN VANCOMYCIN SIGNIFICANT INTERACTION WITH TOBRAMYCIN VECURONIUM SIGNIFICANT INTERACTION WITH AMIKACIN VECURONIUM SIGNIFICANT INTERACTION WITH GENTAMICIN VECURONIUM SIGNIFICANT INTERACTION WITH KANAMYCIN VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH CIMETIDINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH ISOCARBOXAZID VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PARGYLINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH PHENELZINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH SELEGILINE VENLAFAXINE HYDROCHLORIDE SIGNIFICANT INTERACTION WITH TRANYLCYPROMINE VERAPAMIL SIGNIFICANT INTERACTION WITH CARBAMAZEPINE VERAPAMIL SIGNIFICANT INTERACTION WITH THEOPHYLLINE VITAMIN E SIGNIFICANT INTERACTION WITH ANISINDIONE VITAMIN E SIGNIFICANT INTERACTION WITH DICUMAROL VITAMIN E SIGNIFICANT INTERACTION WITH PHENPROCOUMON VITAMIN E SIGNIFICANT INTERACTION WITH WARFARIN VITAMIN K SIGNIFICANT INTERACTION WITH ANISINDIONE VITAMIN K SIGNIFICANT INTERACTION WITH DICUMAROL VITAMIN K SIGNIFICANT INTERACTION WITH PHENPROCOUMON VITAMIN K SIGNIFICANT INTERACTION WITH WARFARIN WARFARIN SIGNIFICANT INTERACTION WITH BUTALBITAL WARFARIN SIGNIFICANT INTERACTION WITH CHOLESTYRAMINE WARFARIN SIGNIFICANT INTERACTION WITH DICLOFENAC WARFARIN SIGNIFICANT INTERACTION WITH DIFLUNISAL WARFARIN SIGNIFICANT INTERACTION WITH ERYTHROMYCIN WARFARIN SIGNIFICANT INTERACTION WITH ETODOLAC WARFARIN SIGNIFICANT INTERACTION WITH FENOPROFEN WARFARIN SIGNIFICANT INTERACTION WITH FLUOXYMESTERONE WARFARIN SIGNIFICANT INTERACTION WITH FLURBIPROFEN

238 National Drug File V. 3.18 April 1998 User Manual Significant Drug Interactions

WARFARIN SIGNIFICANT INTERACTION WITH FOSPHENYTOIN SODIUM WARFARIN SIGNIFICANT INTERACTION WITH IBUPROFEN WARFARIN SIGNIFICANT INTERACTION WITH INDOMETHACIN WARFARIN SIGNIFICANT INTERACTION WITH KETOPROFEN WARFARIN SIGNIFICANT INTERACTION WITH KETOROLAC TROMETHAMINE WARFARIN SIGNIFICANT INTERACTION WITH LEVAMISOLE WARFARIN SIGNIFICANT INTERACTION WITH LEVOTHYROXINE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH LIOTHYRONINE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH MECLOFENAMATE SODIUM WARFARIN SIGNIFICANT INTERACTION WITH MECLOFENAMIC ACID WARFARIN SIGNIFICANT INTERACTION WITH MEFENAMIC ACID WARFARIN SIGNIFICANT INTERACTION WITH METHIMAZOLE WARFARIN SIGNIFICANT INTERACTION WITH METRONIDAZOLE WARFARIN SIGNIFICANT INTERACTION WITH NABUMETONE WARFARIN SIGNIFICANT INTERACTION WITH NAPROXEN WARFARIN SIGNIFICANT INTERACTION WITH OXAPROZIN WARFARIN SIGNIFICANT INTERACTION WITH PAROXETINE WARFARIN SIGNIFICANT INTERACTION WITH PHENYTOIN WARFARIN SIGNIFICANT INTERACTION WITH PIROXICAM WARFARIN SIGNIFICANT INTERACTION WITH PROPYLTHIOURACIL WARFARIN SIGNIFICANT INTERACTION WITH SULFAMETHOXAZOLE WARFARIN SIGNIFICANT INTERACTION WITH SULFINPYRAZONE WARFARIN SIGNIFICANT INTERACTION WITH SULFISOXAZOLE WARFARIN SIGNIFICANT INTERACTION WITH SULINDAC WARFARIN SIGNIFICANT INTERACTION WITH THYROGLOBULIN WARFARIN SIGNIFICANT INTERACTION WITH THYROID WARFARIN SIGNIFICANT INTERACTION WITH THYROID WARFARIN SIGNIFICANT INTERACTION WITH TOLMETIN WARFARIN SIGNIFICANT INTERACTION WITH VITAMIN E WARFARIN SIGNIFICANT INTERACTION WITH VITAMIN K ZALCITABINE (DIDEOXYCYTIDINE,ddC) SIGNIFICANT INTERACTION WITH DIDANOSINE ZIDOVUDINE SIGNIFICANT INTERACTION WITH ATOVAQUONE

April 1998 National Drug File V. 3.18 239 User Manual Appendix D

240 National Drug File V. 3.18 April 1998 User Manual