NEURL2 Antibody

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NEURL2 Antibody CATALOG NUMBER: 30-830 Antibody used in WB on Human Muscle at 0.2-1 ug/ml. Specifications SPECIES REACTIVITY: Human TESTED APPLICATIONS: ELISA, WB APPLICATIONS: NEURL2 antibody can be used for detection of NEURL2 by ELISA at 1:312500. NEURL2 antibody can be used for detection of NEURL2 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. USER NOTE: Optimal dilutions for each application to be determined by the researcher. POSITIVE CONTROL: 1) Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate PREDICTED MOLECULAR 32 kDa WEIGHT: IMMUNOGEN: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NEURL2. HOST SPECIES: Rabbit Properties PURIFICATION: Antibody is purified by peptide affinity chromatography method. PHYSICAL STATE: Lyophilized BUFFER: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 uL of distilled water. Final antibody concentration is 1 mg/mL. CONCENTRATION: 1 mg/ml STORAGE CONDITIONS: For short periods of storage (days) store at 4˚C. For longer periods of storage, store NEURL2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. CLONALITY: Polyclonal CONJUGATE: Unconjugated Additional Info ALTERNATE NAMES: NEURL2, C20orf163, MGC125934, MGC125935, OZZ, Ozz-E3, OZZ-E3 ACCESSION NO.: NP_542787 PROTEIN GI NO.: 18152787 OFFICIAL SYMBOL: NEURL2 GENE ID: 140825 Background BACKGROUND: NEURL2 contains 1 NHR (neuralized homology repeat) domain and 1 SOCS box domain. NEURL2 plays an important role in the process of myofiber differentiation and maturation. NEURL2 is the probable substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, it controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. REFERENCES: 1) Song, R., (2006) J. Biol. Chem. 281 (47), 36391-36400. FOR RESEARCH USE ONLY December 12, 2016.

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Supplementary Information
doi: 10.1038/nature08795 SUPPLEMENTARY INFORMATION Supplementary Discussion Population naming In some contexts, the indigenous hunter-gatherer and pastoralist peoples of southern Africa are referred to collectively as the Khoisan (Khoi-San) or more recently Khoesan (Khoe-San) people. This grouping is based on the unique linguistic use of click-consonants1. Many names, often country-specific, have been used by Bantu pastoralists and European settlers to describe the hunter-gatherers, including San, Saan, Sonqua, Soaqua, Souqua, Sanqua, Kwankhala, Basarwa, Batwa, Abathwa, Baroa, Bushmen, Bossiesmans, Bosjemans, or Bosquimanos. In addition, group-specific names such as !Kung and Khwe are often used for the broader population. The two most commonly used names, “San” and “Bushmen”, have both been associated with much controversy due to derogatory connotations2. “San” has become the more popular term used in Western literature, although “Bushmen” is arguably the more commonly recognized term within the communities. Since they have no collective name for themselves, the term Bushmen was selected for use in this paper as the term most familiar to the participants themselves. Regarding identification of individuals The five men identified in this study have all elected to have their identity made public knowledge. Thus we present two complete personal genomes (KB1 and ABT), a low-coverage personal genome (NB1), and personal exomes for all five men. On a scientific level, identification allows for current and future correlation of genetic data with demographic and medical histories. On a social level, identification allows for maximizing community benefit. For !Gubi, G/aq’o, D#kgao and !Aî, their name represents not only themselves, but importantly their extended family unit and a way of life severely under threat.
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Small Cell Ovarian Carcinoma: Genomic Stability and Responsiveness to Therapeutics
Gamwell et al. Orphanet Journal of Rare Diseases 2013, 8:33 http://www.ojrd.com/content/8/1/33 RESEARCH Open Access Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics Lisa F Gamwell1,2, Karen Gambaro3, Maria Merziotis2, Colleen Crane2, Suzanna L Arcand4, Valerie Bourada1,2, Christopher Davis2, Jeremy A Squire6, David G Huntsman7,8, Patricia N Tonin3,4,5 and Barbara C Vanderhyden1,2* Abstract Background: The biology of small cell ovarian carcinoma of the hypercalcemic type (SCCOHT), which is a rare and aggressive form of ovarian cancer, is poorly understood. Tumourigenicity, in vitro growth characteristics, genetic and genomic anomalies, and sensitivity to standard and novel chemotherapeutic treatments were investigated in the unique SCCOHT cell line, BIN-67, to provide further insight in the biology of this rare type of ovarian cancer. Method: The tumourigenic potential of BIN-67 cells was determined and the tumours formed in a xenograft model was compared to human SCCOHT. DNA sequencing, spectral karyotyping and high density SNP array analysis was performed. The sensitivity of the BIN-67 cells to standard chemotherapeutic agents and to vesicular stomatitis virus (VSV) and the JX-594 vaccinia virus was tested. Results: BIN-67 cells were capable of forming spheroids in hanging drop cultures. When xenografted into immunodeficient mice, BIN-67 cells developed into tumours that reflected the hypercalcemia and histology of human SCCOHT, notably intense expression of WT-1 and vimentin, and lack of expression of inhibin. Somatic mutations in TP53 and the most common activating mutations in KRAS and BRAF were not found in BIN-67 cells by DNA sequencing.
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Genetic Network Identifies Novel Pathways Contributing To
Albright et al. BMC Medical Genomics 2014, 7:51 http://www.biomedcentral.com/1755-8794/7/51 RESEARCH ARTICLE Open Access Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery Jody Albright3, Pamela M Quizon3, Aldons J Lusis4,5,6 and Brian J Bennett1,2,3* Abstract Background: Atherosclerosis, the underlying cause of cardiovascular disease, results from both genetic and environmental factors. Methods: In the current study we take a systems-based approach using weighted gene co-expression analysis to identify a candidate pathway of genes related to atherosclerosis. Bioinformatic analyses are performed to identify candidate genes and interactions and several novel genes are characterized using in-vitro studies. Results: We identify 1 coexpression module associated with innominate artery atherosclerosis that is also enriched for inflammatory and macrophage gene signatures. Using a series of bioinformatics analysis, we further prioritize the genes in this pathway and identify Cd44 as a critical mediator of the atherosclerosis. We validate our predictions generated by the network analysis using Cd44 knockout mice. Conclusion: These results indicate that alterations in Cd44 expression mediate inflammation through a complex transcriptional network involving a number of previously uncharacterized genes. Keywords: Atherosclerosis, Co-expression network, inflammation Background act in part by affecting local inflammation in the vessel Cardiovascular disease (CVD) is the leading cause of wall [3-5]. death in the United States and the incidence of CVD is Inflammation is a fundamental biological process that rapidly increasing in other countries [1]. A common cause provides protection from infection, but when dysregulated, of cardiovascular disease is atherosclerosis, a pathological acts as a source of chronic disease.
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Rabbit Anti-NEURL2 Antibody-SL19213R
SunLong Biotech Co.,LTD Tel: 0086-571- 56623320 Fax:0086-571- 56623318 E-mail:[email protected] www.sunlongbiotech.com Rabbit Anti-NEURL2 antibody SL19213R Product Name: NEURL2 Chinese Name: E3Ubiquitin连接酶蛋白NEURL2抗体 Neuralized E3 Ubiquitin Protein Ligase 2; C20orf163; Chromosome 20 Open Reading Alias: Frame 163; Neuralized Homolog 2 (Drosophila) ; Neuralized-Like 2 (Drosophila); Neuralized-Like Protein 2; Neuralized Homolog 2; OZZ-E3; OZZ; NEUL2_HUMAN; Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep, ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100- 500（Paraffin sections need antigen repair） Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 32kDa Cellular localization: cytoplasmic Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLHwww.sunlongbiotech.com conjugated synthetic peptide derived from human NEURL2:1-100/285 Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed: PubMed This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in Product Detail: striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.
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Datasheet Blank Template
SAN TA C RUZ BI OTEC HNOL OG Y, INC . Neuralized-2 (J-24): sc-133814 BACKGROUND APPLICATIONS Neuralized-2, also known as NEURL2, OZZ or Ozz-E3, is a 285 amino acid Neuralized-2 (J-24) is recommended for detection of Neuralized-2 of human cytoplasmic protein involved in myofiber differentiation and maturation that origin by Western Blotting (starting dilution 1:200, dilution range 1:100- is induced during differentiation. Expressed predominantly in skeletal and 1:1000), immunoprecipitation [1-2 µg per 100-500 µg of total protein (1 ml cardiac muscle, Neuralized-2 localizes to the tips of differentiating myofibers of cell lysate)] and solid phase ELISA (starting dilution 1:30, dilution range and regulates ubiquitination and degradation of β-catenin at the sarcolem ma. 1:30-1:3000). Neuralized-2 contains one SOCS box domain, through which it interacts with Suitable for use as control antibody for Neuralized-2 siRNA (h): sc-75905, Elongin B and Elongin C, and one NHR (neuralized homology repeat) domain Neuralized-2 shRNA Plasmid (h): sc-75905-SH and Neuralized-2 shRNA (h) that is implicated in ubiquitination substrate binding. The gene encoding Lentiviral Particles: sc-75905-V. Neuralized-2 maps to human chromosome 20, which is comprised of approx i- mately 2% of the human genome, contains nearly 63 million bases and Molecular Weight of Neuralized-2: 31 kDa. encodes over 600 genes. Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis and Alagille syndrome are associated with chromosome 20. RECOMMENDED SECONDARY REAGENTS To ensure optimal results, the following support (secondary) reagents are REFERENCES recommended: 1) Western blotting: use goat anti-rabbit IgG-HRP: sc-2004 1.
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Comparative Analysis of the Ubiquitin-Proteasome System in Homo Sapiens and Saccharomyces Cerevisiae
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Developmental Biology Catalog
ptglab.com 1 ANTIBODIES FOR DEVELOPMENTAL BIOLOGY www.ptglab.com 2 Antibodies For Developmental Biology Front Cover: IF result (trunk or trunck-associated region; nucleus stain; RED) of NKX2-2 antibody (13013-1-AP) with E16.5 mouse pancreas by Dr. Nicholas George, Sarvetnick Lab – UNMC. (Green, E-Cadherin; RED, NKX2-2; Blue, DAPI). ptglab.com 3 WELCOME Foreword Developmental biology covers a broad spectrum of scientific research relating to the growth and development of living things. Not only does it concern the embryogenic events immediately following fertilization, it also encompasses the genetic control of cell growth, differentiation and morphogenesis – key components of regeneration and aging in the adult organism. In this development-focused catalog This catalog is essentially a shortlist you will find antibodies to those targets of around one quarter of the antibodies involved in pattern formation, such as Proteintech has for developmental biology HOX gene products and proteins involved protein targets. If you can’t find an antibody in Notch and Hedgehog signaling; neural to your target of choice here, we’re confident tube formation, such as sonic hedgehog that with over 2,000 primary antibodies protein; and organogenesis such as Wnt, relating to development in the complete FGF, BMP and EYA proteins. At the center Proteintech inventory you’ll find what you’re of the catalog, you will also find a primer looking for online at www.ptglab.com. on the primary cilium, with details on Proteintech®* antibodies recognizing the proteins involved in the generation and maintenance of this vital developmental structure. What’s Inside 6–7 Focus Article Antibodies For Cilia Development 8 Focus Article Investigating Kidney Development With Proteintech’s SIX2 Antibody 9–11 Antibodies: ABLIM1 GSK3B 12–13 Antibodies For Cilia Development 14–17 Antibodies: GSK3B ZHX2 18 Contact Us Please Note: All products featured in this catalog are for research use only.
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MAFB Determines Human Macrophage Anti-Inflammatory
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Table S1. the Statistical Metrics for Key Differentially Expressed Genes (Degs)
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The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet Β Cell
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Global Gene Expression During Muscle Hypertrophy Induced by Myostatin Suppression And/Or Beta-Adrenergic Agonist
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Transcriptional Profile of Human Anti-Inflamatory Macrophages Under Homeostatic, Activating and Pathological Conditions
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