Guide to Hormone Support for Healthy Aging‡
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Ctz78-02 (02) Lee Et Al.Indd 51 14 08 2009 13:12 52 Lee Et Al
Contributions to Zoology, 78 (2) 51-64 (2009) Variation in the nocturnal foraging distribution of and resource use by endangered Ryukyu flying foxes(Pteropus dasymallus) on Iriomotejima Island, Japan Ya-Fu Lee1, 4, Tokushiro Takaso2, 5, Tzen-Yuh Chiang1, 6, Yen-Min Kuo1, 7, Nozomi Nakanishi2, 8, Hsy-Yu Tzeng3, 9, Keiko Yasuda2 1 Department of Life Sciences and Institute of Biodiversity, National Cheng Kung University, Tainan 701, Taiwan 2 The Iriomote Project, Research Institute for Humanity and Nature, 671 Iriomote, Takatomi-cho, Okinawa 907- 1542, Japan 3 Hengchun Research Center, Taiwan Forestry Research Institute, Pingtung 946, Taiwan 4 E-mail: [email protected] 5 E-mail: [email protected] 6 E-mail: [email protected] 7 E-mail: [email protected] 8 E-mail: [email protected] 9 E-mail: [email protected] Key words: abundance, bats, Chiroptera, diet, figs, frugivores, habitat Abstract Contents The nocturnal distribution and resource use by Ryukyu flying foxes Introduction ........................................................................................ 51 was studied along 28 transects, covering five types of habitats, on Material and methods ........................................................................ 53 Iriomote Island, Japan, from early June to late September, 2005. Study sites ..................................................................................... 53 Bats were mostly encountered solitarily (66.8%) or in pairs (16.8%), Bat and habitat census ................................................................ -
Identification and Characterization of Phenolics from Ethanolic Extracts of Phyllanthus Species by HPLC-ESI-QTOF-MS/MS
Author’s Accepted Manuscript Identification and characterization of phenolics from ethanolic extracts of Phyllanthus species by HPLC-ESI-QTOF-MS/MS Sunil Kumar, Awantika Singh, Brijesh Kumar www.elsevier.com/locate/jpa PII: S2095-1779(17)30016-3 DOI: http://dx.doi.org/10.1016/j.jpha.2017.01.005 Reference: JPHA347 To appear in: Journal of Pharmaceutical Analysis Received date: 25 June 2016 Revised date: 13 January 2017 Accepted date: 17 January 2017 Cite this article as: Sunil Kumar, Awantika Singh and Brijesh Kumar, Identification and characterization of phenolics from ethanolic extracts of Phyllanthus species by HPLC-ESI-QTOF-MS/MS, Journal of Pharmaceutical Analysis, http://dx.doi.org/10.1016/j.jpha.2017.01.005 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Identification and characterization of phenolics from ethanolic extracts of Phyllanthus species by HPLC-ESI-QTOF-MS/MS Sunil Kumara, Awantika Singha,b, Brijesh Kumara,b* aSophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow- 226031, Uttar Pradesh, India bAcademy of Scientific and Innovative Research (AcSIR), New Delhi-110025, India [email protected] [email protected] *Corresponding author at: Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow-226031. -
Proximate Composition and Mineral Analysis of Mucuna Utilis (Velvet Bean)
IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.Volume 8, Issue 10 Ver. I (Oct. 2015), PP 42-45 www.iosrjournals.org Proximate Composition and Mineral Analysis of Mucuna utilis (Velvet Bean) Ezeokonkwo Mercy A.*1, Okafor Sunday N.2 1. Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka,410001, Enugu State, Nigeria 2. Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria Abstract: The standard procedures were followed to analyze the proximate composition and mineral analysis of Mucuna utilis. The caloric value was calculated from crude protein, crude fat, crude fiber, carbohydrate, moisture and ash content. The iron (Fe), zinc (Zn), calcium (Ca), manganese (Mn) and magnesium (Mg), sodium (Na), potassium (K) and phosphorus (P) were determined by Atomic Absorption Spectrophotometer. The results showed that Mucuna utilis contained ash (6.0%), crude protein (22.94%), crude fat (2.94%), crude fiber (12.50%), moisture (12.50%) and carbohydrate (43.11%). The energy calculated gave 290.75Kcal/100g. The mineral determination gave the data that Mucuna utilis contained calcium (5.25 mg/g), phosphorus (0.02 mg/g), magnesium (1.63 mg/g), manganese (0.0mg/g), iron (0.95 mg/g), sodium (1.17 mg/g), potassium (0.13 mg/g) and zinc (0.21 mg/g). This study concluded that the tested Mucuna utilis contained highest amount of carbohydrate and lowest amount of crude fibre. Similarly, among minerals tested, Mucuna utilis contained highest amount of calcium and no manganese at all. Keywords: carbohydrate, mineral analysis, Mucuna utilis, protein, proximate composition I. -
Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson's Disease: a Comparative Study
antioxidants Article Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study Lyubka P. Tancheva 1,*, Maria I. Lazarova 2 , Albena V. Alexandrova 3, Stela T. Dragomanova 1,4, Ferdinando Nicoletti 5 , Elina R. Tzvetanova 3, Yordan K. Hodzhev 6, Reni E. Kalfin 2, Simona A. Miteva 1, Emanuela Mazzon 7 , Nikolay T. Tzvetkov 8 and Atanas G. Atanasov 2,9,10,11,* 1 Department of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria; [email protected] (S.T.D.); [email protected] (S.A.M.) 2 Department of Synaptic Signaling and Communications, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria; [email protected] (M.I.L.); reni_kalfi[email protected] (R.E.K.) 3 Department Biological Effects of Natural and Synthetic Substances, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria; [email protected] (A.V.A.); [email protected] (E.R.T.) 4 Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University, Varna 9002, Bulgaria 5 Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, Italy; [email protected] 6 Department of Sensory Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria; [email protected] 7 IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy; [email protected] 8 Department of Biochemical -
Premenstrual Syndrome: a Natural Approach to Management
CNI506 8/99 Vol. 5, No. 6 APPLIED NUTRITIONAL SCIENCE REPORTS Copyright © 1997 Advanced Nutrition Publications, Inc. rev. 1999 Premenstrual Syndrome: A Natural Approach to Management BY JOSEPH L. MAYO, MD, FACOG ABSTRACT: Premenstrual syndrome (PMS) is a disorder that imbalances, nutritional insufficiencies, and psychologic factors. occurs during the luteal phase of the menstrual cycle, producing A nutritional approach to PMS that takes into account the complex a diverse number of physical and emotional changes. The most interactions of all bodily systems that influence hormonal balance common symptoms of PMS include bloating, backache, breast and neuroendocrine function, with an emphasis on the liver, is tenderness, food cravings, fatigue, irritability, and depression. recommended. The nutritional factors that have been studied The timing of the appearance and disappearance of symptoms, include vitamin B6, magnesium, zinc, choline, vitamin E, and rather than the presence of specific symptoms, is of more essential fatty acids, in addition to weight management and importance in the diagnosis of PMS. The direct cause of PMS is stress reduction. Herbal therapies have also proven beneficial in unknown, although there are numerous theories relating to hormonal the management of PMS. PREMENSTRUAL SYNDROME symptoms such as bloating, breast tenderness, and headache (Table 1).3-5 These diverse symptoms may range from mild Cyclic symptoms in women of reproductive age have been to incapacitating. In some women a single symptom, such recognized for thousands of years. First appearing in the medical as depression, may predominate, whereas others may have literature in 1931 and originally termed “premenstrual tension,” several symptoms.1 this condition has been renamed “premenstrual syndrome” (PMS) in an effort to take into account the different clinical Table. -
Effects of Aqueous Seed Extracts of Mucuna Sloanei (Fabaceae) on Body Weight and Some Biochemical Parameters of Rattus Novergicus
Vol. 17(28), pp. 885-891, 11 July, 2018 DOI: 10.5897/AJB2017.16112 Article Number: DEEF4BC57771 ISSN: 1684-5315 Copyright ©2018 Author(s) retain the copyright of this article African Journal of Biotechnology http://www.academicjournals.org/AJB Full Length Research Paper Effects of aqueous seed extracts of Mucuna sloanei (Fabaceae) on body weight and some biochemical parameters of Rattus novergicus Ugwu, Godwin C.1*, Ejere, Vincent C.1, Okanya, Chinagorom L.1, Omeje, Joy N.2, Egbuji, Jude 1 3 1 V. , Onu, Martina C. and Chukwuka, Christian O. 1Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria. 2Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria. 3Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria. Received 14 June, 2017; Accepted 14 December, 2017 Mucuna sloanei is an annual leguminous plant widely used among the various ethnic groups in Nigeria. The effects of aqueous M. sloanei seed extract on the body weight and some biochemical parameters of 48 normal male Rattus novergicus (albino rats) were investigated for 28 days. The rats were divided into control group (A) which received distilled water and treatment groups (B, C and D) that received oral administration of 100, 200 and 400 mg/kg body weight of the seed extract, respectively. Each group was further divided into three replicates of four rats each. Blood samples were collected before the experiment started (week 0) and at weekly interval from one rat per replicate. The biochemical profiles were determined using bioassay. The lethal dose (LD50) of the aqueous seed extracts of M. -
Study of Some Pharmacological Actions of Berberine*
July 1971 Ind. J. Physiol, & Pharmac, aration, properties and molecular thesaponin of Achyranthes aspera, STUDY OF SOME PHARMACOLOGICAL ACTIONS OF BERBERINE* M. SABIR AND N. K. BHIDE neon the phosphorylase activity of Department of Pharmacology, All-India Institute of Medical Sciences, New Delhi-16 Summary: Berberine produced reversible and dose-dependant hypotension in the anaesthe- tized dog, cat, rat and frog. The hypotension was studied in details in the dog. It was not due to the release of tissue histamine and was not blocked by atropine, rnepyramine, phenoxyben- zamine, propranolol, pentolinium, bilateral vagotomy and ablation of brain. Propranolol- pentoliniurn combination, however, blocked this effect in some animals and, for a short period, reversed it to hypertension in the others. Berberine did not alter the actions of carbachol, histamine, bradykinin, isoprenaline, adrenaline and nor-adrenaline on the blood pressure. It increased the volume of spleen and hind limb. Berberine appears to induce hypotension by directly acting on the blood vessels. Berberine stimulated the ill si/It dog heart and produced tachycardia which outlasted hypotension. In smaller doses, it stimulated the isolated heart of the rabbit and the frog. It temporarily reversed the depression of the frog heart perfused with low calcium Ringer. In the dog and frog, myocardial depression is not likely to contribute to the berberine-iriduced hypotension. The respiratory stimulant action was parrallel to, and could be a reflex phenomenon provoked by hypotension. In mice, berberine lowered the rectal temperature, reduced the spontaneous motor activity and prolonged the hexobarbitone sleeping time. It increased the incidence of death but not the severity of tremors in the tremorine-treated mice. -
Fruits and Seeds of Genera in the Subfamily Faboideae (Fabaceae)
Fruits and Seeds of United States Department of Genera in the Subfamily Agriculture Agricultural Faboideae (Fabaceae) Research Service Technical Bulletin Number 1890 Volume I December 2003 United States Department of Agriculture Fruits and Seeds of Agricultural Research Genera in the Subfamily Service Technical Bulletin Faboideae (Fabaceae) Number 1890 Volume I Joseph H. Kirkbride, Jr., Charles R. Gunn, and Anna L. Weitzman Fruits of A, Centrolobium paraense E.L.R. Tulasne. B, Laburnum anagyroides F.K. Medikus. C, Adesmia boronoides J.D. Hooker. D, Hippocrepis comosa, C. Linnaeus. E, Campylotropis macrocarpa (A.A. von Bunge) A. Rehder. F, Mucuna urens (C. Linnaeus) F.K. Medikus. G, Phaseolus polystachios (C. Linnaeus) N.L. Britton, E.E. Stern, & F. Poggenburg. H, Medicago orbicularis (C. Linnaeus) B. Bartalini. I, Riedeliella graciliflora H.A.T. Harms. J, Medicago arabica (C. Linnaeus) W. Hudson. Kirkbride is a research botanist, U.S. Department of Agriculture, Agricultural Research Service, Systematic Botany and Mycology Laboratory, BARC West Room 304, Building 011A, Beltsville, MD, 20705-2350 (email = [email protected]). Gunn is a botanist (retired) from Brevard, NC (email = [email protected]). Weitzman is a botanist with the Smithsonian Institution, Department of Botany, Washington, DC. Abstract Kirkbride, Joseph H., Jr., Charles R. Gunn, and Anna L radicle junction, Crotalarieae, cuticle, Cytiseae, Weitzman. 2003. Fruits and seeds of genera in the subfamily Dalbergieae, Daleeae, dehiscence, DELTA, Desmodieae, Faboideae (Fabaceae). U. S. Department of Agriculture, Dipteryxeae, distribution, embryo, embryonic axis, en- Technical Bulletin No. 1890, 1,212 pp. docarp, endosperm, epicarp, epicotyl, Euchresteae, Fabeae, fracture line, follicle, funiculus, Galegeae, Genisteae, Technical identification of fruits and seeds of the economi- gynophore, halo, Hedysareae, hilar groove, hilar groove cally important legume plant family (Fabaceae or lips, hilum, Hypocalypteae, hypocotyl, indehiscent, Leguminosae) is often required of U.S. -
Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids Of
DMD Fast Forward. Published on June 26, 2020 as DOI: 10.1124/dmd.120.091041 This article has not been copyedited and formatted. The final version may differ from this version. DMD # 91041 Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects Matthew G. McDonald, Dan-Dan Tian1, Kenneth E. Thummel, Mary F. Paine, Allan E. Rettie Departments of Medicinal Chemistry (MGM, AER) and Pharmaceutics (KET), School of Pharmacy, Downloaded from University of Washington, Seattle, WA, 98195; Department of Pharmaceutical Sciences (DDT, MFP), College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 99202; Center of Excellence for Natural Product Drug Interaction Research (KET, MFP, AER) dmd.aspetjournals.org at ASPET Journals on September 26, 2021 1 DMD Fast Forward. Published on June 26, 2020 as DOI: 10.1124/dmd.120.091041 This article has not been copyedited and formatted. The final version may differ from this version. DMD # 91041 Running Title: Complex Effects of Goldenseal Alkaloids on CYPs Corresponding author: Matthew G. McDonald, Ph.D. Department of Medicinal Chemistry University of Washington, Box 357610 1959 NE Pacific, Seattle WA 98195 Telephone: (206) 384-3386 Downloaded from Fax: (206) 685-3252 Email: [email protected] dmd.aspetjournals.org Number of: Text pages: 44 Tables: 6 Figures: 6 at ASPET Journals on September 26, 2021 References: 39 Words in Abstract: 250 Words in Introduction: 734 Words in Discussion: 1701 Abbreviations: AUC, area under the plasma concentration versus time curve; CYP, cytochrome P450; fu,HLM, fraction unbound in human liver microsomes; fu,p, fraction unbound in plasma; GSE, goldenseal extract; HLMs, human liver microsomes; Imax,u, maximum unbound plasma concentration; KPi, potassium phosphate; MDZ, midazolam; MI, metabolic intermediate; NP, natural product; PBPK, physiologically- based pharmacokinetic; TDI, time-dependent inhibition 2 DMD Fast Forward. -
Dietary Neurotransmitters: a Narrative Review on Current Knowledge
nutrients Review Dietary Neurotransmitters: A Narrative Review on Current Knowledge Matteo Briguglio 1,* ID , Bernardo Dell’Osso 2,3, Giancarlo Panzica 4 ID , Antonio Malgaroli 5, Giuseppe Banfi 6, Carlotta Zanaboni Dina 1, Roberta Galentino 1 and Mauro Porta 1 1 Tourette’s Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy; [email protected] (C.Z.D.); [email protected] (R.G.); [email protected] (M.P.) 2 Department of Pathophysiology and Transplantation, I.R.C.C.S. Ca’ Granda Foundation, Ospedale Maggiore Policlinico, 20122 Milan, Italy; [email protected] 3 Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA 4 Department of Neuroscience, Rita Levi Montalcini, University of Turin, 10126 Turin, Italy; [email protected] 5 Neurobiology of Learning Unit, Division of Neuroscience, Vita-Salute San Raffaele University, 20132 Milan, Italy; [email protected] 6 Scientific Direction, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy; banfi[email protected] * Correspondence: [email protected]; Tel.: +39-338-608-7042 Received: 13 April 2018; Accepted: 8 May 2018; Published: 13 May 2018 Abstract: Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. -
Prevention of Hormonal Mammary Carcinogenesis in Rats by Dietary Berries and Ellagic Acid
University of Kentucky UKnowledge University of Kentucky Doctoral Dissertations Graduate School 2007 PREVENTION OF HORMONAL MAMMARY CARCINOGENESIS IN RATS BY DIETARY BERRIES AND ELLAGIC ACID Harini Sankaran Aiyer University of Kentucky, [email protected] Right click to open a feedback form in a new tab to let us know how this document benefits ou.y Recommended Citation Aiyer, Harini Sankaran, "PREVENTION OF HORMONAL MAMMARY CARCINOGENESIS IN RATS BY DIETARY BERRIES AND ELLAGIC ACID" (2007). University of Kentucky Doctoral Dissertations. 508. https://uknowledge.uky.edu/gradschool_diss/508 This Dissertation is brought to you for free and open access by the Graduate School at UKnowledge. It has been accepted for inclusion in University of Kentucky Doctoral Dissertations by an authorized administrator of UKnowledge. For more information, please contact [email protected]. ABSTRACT OF DISSERTATION Harini Sankaran Aiyer The Graduate School University of Kentucky 2007 PREVENTION OF HORMONAL MAMMARY CARCINOGENESIS IN RATS BY DIETARY BERRIES AND ELLAGIC ACID ABSTRACT OF DISSERTATION A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Nutritional Sciences at the University of Kentucky By Harini Sankaran Aiyer Louisville, Kentucky Director: Dr. Ramesh C.Gupta, Professor of Preventive Medicine Lexington, Kentucky 2007 Copyright © Harini Sankaran Aiyer, 2007 . ABSTRACT OF DISSERTATION PREVENTION OF HORMONAL MAMMARY-CARCINOGENESIS IN RATS BY DIETARY BERRIES AND ELLAGIC ACID. Breast cancer is the most frequently diagnosed cancer among women around the world. The hormone 17ß-estradiol (E2) is strongly implicated as a causative agent in this cancer. Since estrogen acts as a complete carcinogen, agents that interfere with the carcinogenic actions of E2 are required. -
Pharmaceutical and Veterinary Compounds and Metabolites
PHARMACEUTICAL AND VETERINARY COMPOUNDS AND METABOLITES High quality reference materials for analytical testing of pharmaceutical and veterinary compounds and metabolites. lgcstandards.com/drehrenstorfer [email protected] LGC Quality | ISO 17034 | ISO/IEC 17025 | ISO 9001 PHARMACEUTICAL AND VETERINARY COMPOUNDS AND METABOLITES What you need to know Pharmaceutical and veterinary medicines are essential for To facilitate the fair trade of food, and to ensure a consistent human and animal welfare, but their use can leave residues and evidence-based approach to consumer protection across in both the food chain and the environment. In a 2019 survey the globe, the Codex Alimentarius Commission (“Codex”) was of EU member states, the European Food Safety Authority established in 1963. Codex is a joint agency of the FAO (Food (EFSA) found that the number one food safety concern was and Agriculture Office of the United Nations) and the WHO the misuse of antibiotics, hormones and steroids in farm (World Health Organisation). It is responsible for producing animals. This is, in part, related to the issue of growing antibiotic and maintaining the Codex Alimentarius: a compendium of resistance in humans as a result of their potential overuse in standards, guidelines and codes of practice relating to food animals. This level of concern and increasing awareness of safety. The legal framework for the authorisation, distribution the risks associated with veterinary residues entering the food and control of Veterinary Medicinal Products (VMPs) varies chain has led to many regulatory bodies increasing surveillance from country to country, but certain common principles activities for pharmaceutical and veterinary residues in food and apply which are described in the Codex guidelines.