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United States Patent (10) Patent No.: US 7,189,822 B2 Goddard Et Al

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United States Patent (10) Patent No.: US 7,189,822 B2 Goddard Et Al US007 189822B2 (12) United States Patent (10) Patent No.: US 7,189,822 B2 Goddard et al. (45) Date of Patent: Mar. 13, 2007 (54) ANTIBODIES TO A POLYPEPTIDE OTHER PUBLICATIONS ENCODED BY ANUCLEC ACID UNDEREXPRESSED IN STOMACH AND Pennica et al. WISP genes are members of the connective tissue LUNG TUMIOR growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors (1998), (75) Inventors: Audrey Goddard, San Fransisco, CA PNAS, vol. 95, pp. 14717-14722.* (US); Paul J. Godowski, Hillsborough, Sen et al. Aneuploidy and cancer (2000), Curr. Opinion in Oncol CA (US); J. Christopher Grimaldi, ogy, vol. 12, pp. 82-88.* San Fransisco, CA (US); Austin I. Haynes et al., Proteome analysis: Biological Assay or data archive? Gurney, Belmont, CA (US); William I. (1998), Electophoresis, vol. 19, pp. 1862-1871. Wood, Hillsborough, CA (US) Hu et al., Analysis of genomic and Proteomic Data using Advanced (73) Assignee: Genentech, Inc., South San Francisco, literature mining (2003), J. of Proteome Research, vol. 2, pp. CA (US) 405-412. Chen et al. Discordant Protein and mRNA Expression in Lung (*) Notice: Subject to any disclaimer, the term of this Adenocarcinomas (2002), Molecular and Cellular Proteomics, vol. patent is extended or adjusted under 35 1, pp. 304-313.* U.S.C. 154(b) by 622 days. Gygiet al. Correlation between Protein and mRNA Abundance in Yeast (1999), Molecular and Cellular Biology, vol. 19, pp. 1720 (21) Appl. No.: 10/063,660 1730.* 1-1. Klein et al. Selection for Genes Encoding Secreted Proteins and (22) Filed: May 7, 2002 Receptors. Proc. Natl. Acad. Sci., 93:7108-7113 (1996). (65) Prior Publication Data Database Search, DNA Sequence Alignments BLASTN 2.2.1 Jul. 12, 2001, NCBI). US 2003/O181684 A1 Sep. 25, 2003 Database Search, Protein Sequence Alignments BLASTN 2.2.1 Related U.S. Application Data Jul. 12, 2001, NCBI). Alberts, et al. 1994. Molecular Biology of the Cell, 3rd Edition, pp. (63) Continuation of application No. 10/006,867, filed on 403-404, 453. New York: Garland Publishing. Dec. 6, 2001, which is a continuation of application Alberts, et al. 2002. Molecular Biology of the Cell, 4th Edition, pp. No. PCT/US00/23328, filed on Aug. 24, 2000. 302, 363-364, 379, 435. New York: Garland Publishing. (60) Provisional application No. 60/170,262, filed on Dec. Grimaldi, et al. 1989. The t05:14) chromosomal translocation in a 9, 1999. case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Blood, 73(8):2081-2085. (51) Int. Cl. Hanna, etal. Aug. 1999. HER-2/neu breast cancer predictive testing. C07K 6/00 (2006.01) Pathology Associates Medical Laboratories. (52) U.S. Cl. ............................... 530/387.9; 530/387.7; Lewin, B. 1997. Regulation of Transcription, Chap. 29, pp. 847 530/387.1:530/388.1:530/388.15:530/391.1; 848. Genes VI. New York: Oxford University Press. 530/391.3 Meeker, et al. 1990. Activation of the interleukin-3 gene by chro (58) Field of Classification Search ............. 530/387.1, mosome translocation in acute lymphocytic leukemia with 530/3877,387.9, 388.1, 388.15, 391.3, 350; eosinophilia. Blood, 76(2):285-289. 435/7.1 See application file for complete search history. (Continued) (56) References Cited Primary Examiner Christine J. Saoud Assistant Examiner Jegatheesan Seharaseyon U.S. PATENT DOCUMENTS (74) Attorney, Agent, or Firm Elizabeth M. Barnes; Mark 5,536,637 A 7, 1996 Jacobs T. Kresnak; Knobbe Martens Olson & Bear, LLP 5,830,670 A * 11/1998 de la Monte et al. ........ 435/72 6,025,156 A 2/2000 Gwynn et al. (57) ABSTRACT 6,124,433 A 9, 2000 Falb et al. 6,156,500 A 12, 2000 Fab 6,228,5826,162,604 B1A 1220005, 2001 JacobRodier et al. The present invention is directed to novel polypeptides and 6,395,306 B1 5, 2002 Cui et al. to nucleic acid molecules encoding those polypeptides. Also 6,414,117 B1 7/2002 Levinson provided herein are vectors and host cells comprising those 6,465,185 B1 10/2002 Goldfine et al. nucleic acid sequences, chimeric polypeptide molecules 6,498,235 B2 12/2002 Sheppard et al. comprising the polypeptides of the present invention fused 6,562,343 B1 5, 2003 Levinson to heterologous polypeptide sequences, antibodies which 6,730,5026,645,499 B1B2 11/20035/2004 VanLal etHijum al. et al. bind to the polypeptides of the present invention and to 6,737,522 B2 5/2004 Sundick et al. methods for producing the polypeptides of the present invention. FOREIGN PATENT DOCUMENTS WO WO 97,38085 10, 1997 5 Claims, 168 Drawing Sheets US 7,189,822 B2 Page 2 OTHER PUBLICATIONS Dagenais, et al. 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