Moving with the Nation
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES An Institute of National Importance BANGALORE - 560 029
ANNUAL REPORT 2 0 1 4 - 2 0 1 5
NIMHANS An Institute of National Importance Prof. M.V. Govindaswamy Founder Director 1954 - 1961
he National Institute of Mental Health and Neuro Sciences (NIMHANS) is a multidisciplinary Institute for Tpatient care and academic pursuit in the field of mental health and neurosciences. NIMHANS is synonymous with providing high standards of clinical care, quality training and cutting-edge research in frontier areas of the brain and mind. The Institute, with its philosophical underpinning of an integrated and multidisciplinary approach and its cognizance of societal needs, has prioritised its objectives as providing comprehensive patient care, manpower development and research. At the institute, advances in genomics, computational neuroscience, mathematical modelling, neuroimaging, molecular biology and a host of new disciplines including public health are being translated to help society and also promote the growth of knowledge. Ever since its inception, a special feature of this Institute is combining research and training with promotive, preventive and curative aspects of clinical services in Mental Health and Neurosciences. This ethos continues to the present day. NIMHANS represents a unique model of a successful partnership between the Union and State Governments (Ministry of Health and Family Welfare, Government of India and the Government of Karnataka).
The manpower development programmes at NIMHANS reflect the extent to which the Institute has succeeded in integrating and nurturing disciplines such as behavioural sciences, neurosciences, basic biological sciences and ancient health systems under one roof. The Institute frequently provides advice to the Central and State Governments in the matter of policies and strategies for mental health care, evolving the national programme for mental health and improving psychiatric facilities in the country. The Institute has also emerged as the nodal centre for evolving national policies in the field of mental health, neurosciences and injury.
NIMHANS is today a centre for excellence in the country for mental health and neuroscience. The institute has produced more than 1,000 Psychiatrists, about 600 Clinical Psychologists and Psychiatric Nurses so far. Alumni from NIMHANS are spread across the country and the world.
Recognising its eminent academic position, and the growth in size and stature, the central government declared NIMHANS a ‘Deemed University’ in 1994 and in 2012 NIMHANS has become an ‘Institute of National Importance’. Vision
To be a world leader in the area of Mental Health and Neurosciences and evolve state-of-the-art approaches to patient care through translational research Mission
Establish the highest standards of evidence-based all sections of society and ages including the vulnerable care for psychiatric and neurological disorders and population rehabilitation Evolve and monitor the strategies for disaster Develop expertise and set standards of care for diseases management and psycho-social rehabilitation in of public health relevance in the developing world different cultural and ethnic groups. Work with the government and provide consultancy Promote Mental Health literacy and eliminate the services for policy planning and monitoring strategies stigma attached to the Mental and Neurological in the field of Mental Health and Neurosciences and illnesses by taking the measures and the delivery system facilitate execution of national health programme. to the centres of primary health care honouring the human rights and dignity Human resource capacity building by training in diverse fields related to Mental Health and Neurosciences. Integrate allopathic and oriental medicine into health care delivery and promote evidence-based research Develop and strengthen inter-disciplinary, inter- institutional and international collaboration with Integrate physical and metaphysical aspects of universities and research institutes across the globe Neuroscience research to promote yoga and its to foster scientific research, training in advanced application to positive mental health. technology and exchange of ideas in the areas of Mental Health and Neurosciences. Participate in broad field of Neuroscience and Behavioral Research applicable to human ethics, organ Strive to enhance equitable accessibility of primary transplantation, stem cell research, space science, and care in Mental Health and Neurological Disorders to nuclear science. National Institute of Mental Health and Neuro Sciences Organogram
DIRECTOR / VICE-CHANCELLOR
Administration Academics Hospital Services Finance & Internal Accounts Audit Registrar Medical DFA & CAO Deans Superintendent AO AO (A&E) Resident AO Accounts Medical Officer (Hospital) Officers Behavioural Basic Sciences Neuro Sciences Sciences
Special AAO AAO AAO AAO AAO AAO AAO Casualty AAO AAO Officer (Stores) (Personnel) (Coordination) (Claims) (Hospital) (DP&NR) (OPD) Medical (Accounts) (Projects) Officer
Biophysics Biostatistics Human Genetics Neurochemistry Clinical Neurosciences Epidemiology Neuroanaesthesia Neuro Imaging & Interventional Radiology Neurology Neuropathology Neuromicrobiology Neurophysiology Neurovirology Psychopharmacology Neurosurgery Speech Pathology & Audiology Transfusion Medicine & Haematology
Health Education Clinical Psychology Nursing Neurological Rehabilitation Psychiatric Social Work Psychiatry Child & Adolescent Psychiatry
Psychiatric Rehabilitation Services
Special Centres (Academic & Research)
• Centre for Addiction Medicine • Neurobiology Research Centre • NIMHANS Centre for Well Being • Centre for Public Health • Free Legal Aid Clinic • Sakalawara Community Mental Health Centre Sincere and Respectful Homage
Dr. R Marthanda Varma, the founding Director of NIMHANS was an internationally acclaimed Neurosurgeon. A practical visionary, he visualized and oversaw the amalgamation of the Mental Health Hospital and the All India Institute of Mental Health into National Institute of Mental Health and Neuro Sciences. Never known to have lost his temper, he was known for being a self- effacing and genuinely caring person in all walks of life and for all persons who came to his contact. He will always be remembered as a legendary and gifted surgeon, relentless researcher and a teacher par excellence.
Dr. RM Varma joined the AIIMH as faculty of Neurosurgery and was instrumental in transforming Neurosurgery into a core discipline at the AIIMH. Like his predecessor Dr. Govindaswamy, he sought to integrate the disciplines of the brain and mind. He was the Director of the AIIMH from 1969 till its reorganization as NIMHANS in 1974. Under his stewardship, NIMHANS became an autonomous institute with bi-governmental and university participation and Dr. Varma was its founding Director from 1974 to 1979. During 1977-78, for a brief period, he was appointed as Deputy Director General of Health Services, Government of India. Dr. R Marthanda Varma (7th September 1922 – 10th March 2015) He had served as Honorary Surgeon to the President of India, and as Advisor in mental health and Neurosurgery to the Government of India. Dr. Varma received many prestigious awards including the Rajyotsava Award (1969) and Sir Visvesvaraya Award (1998) from the Government of Karnataka and the most coveted Padma Shri in 1972 from Government of India.
Dr. SK Ramachandra Rao with Dr. RM Varma, Dept. of Neurosurgery Hon. Union Minister Dr. Karan Singh and Hon. Chief Minister and the AIIMH team at the lawns of the Hospital, early 1960s Mr. Devaraj Urs at the Inauguration of NIMHANS, 14th February, 1975
Front line L to R: Health Minister Mr. Siddaveerappa, Dr. RM Varma showing the film on chemothalamotomy to Mr. BV Dr. RM Varma, and Hon. President Mr. VV Giri. Baliga, Speaker of the Mysore Assembly. Chemothalamotomy was a procedure innovated by Dr. Varma to help patients with Parkinsonism From the Director’s Desk...... 9 Awards, Honours and Key Assignments ...... 37 Visitors to Nimhans...... 49 Patient Care Activities...... 57 Human Resource Development...... 80 Conference /Symposia/Workshops I. Scientific Programs Organised at NIMHANS ...... 91 A. International...... 91 B. National ...... 92 II. Scientific Programs Organised Outside NIMHANS...... 100 A. International...... 100 B. National ...... 100 III. Specific Training Underwent by Faculty / Staff...... 104 Central Facilities...... 108 Research Activities Biophysics...... 126 Biostatistics...... 132 Child and Adolescent Psychiatry ...... 133 Clinical Psychology...... 135 Epidemiology...... 150 Human Genetics ...... 152 Mental Health Education...... 155 Neuroanaesthesia...... 155 Neurochemistry...... 158 Neuro Imaging and Interventional Radiology (NIIR)...... 164 Neurological Rehabilitation...... 168 Neurology...... 169 Neuromicrobiology...... 175 Neuropathology...... 177 Neurophysiology...... 180 Neurosurgery...... 197 Neurovirology...... 200 Nursing …...... 202 Psychiatry...... 206 Psychiatric Rehabilitation...... 212 Psychiatric Social Work...... 213 Psychopharmacology...... 223 Speech Pathology and Audiology...... 223 Ayurveda …...... 225 Clinical Neurosciences...... 225 Publications A. International Journals...... 228 B. National Journals...... 246 C. Book Chapters/Conference Proceedings...... 254 D. Monographs/Manuals/Reports...... 257 E. Newsletters/Souvenirs...... 259 F. Articles for General Public/IEC Materials...... 259 G. Books Published...... 261 Contributions to Scientific Deliberations A. Presentations in International Conferences...... 262 B. Presentations in National Conferences...... 273 C. Resource Persons...... 300 D. Radio/TV/Phone-in Programmes...... 306 Public Lectures...... 308 Statutory Bodies...... 311 Faculty and Staff...... 321 Finance and Accounts...... 330 Homage ...... 359 Ravi Hegde From the Director’s Desk
It is my privilege to share with you the Annual Report of National Institute of Mental Health & Neuro Sciences (NIMHANS) for the year 2014–2015. In pursuit of its vision and mission, NIMHANS has emerged to be a premier institution of mind, brain and behavior in the country. That it has gained recognition as an Institute of National Importance through an Act of Parliament, is a witness to the path it has taken and road it intends to travel.
Acclaimed for specialized services, NIMHANS has set high standards of clinical care and academic excellence. Remaining relevant all along, NIMHANS has pursued the tradition of renewing partnerships and forging new ties with various prominent institutes and organisations within India and across the globe. It has been able to demonstrate that promoting collaborative research and pursuing academic programmes globally in the field of mental health and neurosciences is mutually beneficial. Leading cutting-edge research in the frontier areas, it has successfully harmonized patient care with clinical research, promoting high-impact research and also delivering optimal patient care.
This report along with the audited statement of accounts will provide a bird’s-eye view of the multifarious activities undertaken during the period 1st April 2014 to 31st March 2015. Together, we are on this relentless journey to serve our country, and we would like to rededicate and renew our pledge to bring succor to those who need it the most. On behalf of the faculty, staff, and students of NIMHANS, I would like to express and record our sincere and heartfelt gratitude to all those who have inspired and encouraged us to make NIMHANS what it is today.
Dr. P. Satishchandra Director/Vice-Chancellor Annual Report 2014-15
1. Patient Care Services 2. Human Resources Development
2.1 Academic programmes NIMHANS remains committed to delivering highest standards of clinical care through interdisciplinary teamwork, NIMHANS continues to evolve with the changing face of expert consultation, and quality outcomes. The state-of-the- health care, facilitating opportunities for academic growth art facilities bolstered by highly skilled professionals and and achievement. The Institute also plays a vital role in technicians—who are dedicated to providing the patients with creating new directions for professional development through compassionate and comprehensive care—make NIMHANS a advanced academic programmes and enhanced mentoring. centre of excellence and specialized medical expertise. NIMHANS has started two new super speciality courses, DM in Neuropathology and DM in Addiction Medicine, from the NIMHANS, being a public sector institution, provides high academic year 2015-16. These new and specialised courses quality and affordable patient care services, primarily reaching will augment the manpower of pre-existing Post-Doctoral out to the less privileged sections of the society. It has the largest Fellows in various subspecialties in both clinical and preclinical psychiatric service in the country for children and adolescents. branches and develop highly trained medical specialists for the It is also home to the largest neuropsychiatric rehabilitation country. centre, a community mental health and rehabilitation centre catering to the rural areas of Bengaluru. It has the unique The Institute has extended the MOU with Maastricht distinction of providing free legal assistance for patients and University, Netherland and University of Liverpool (UK) for their families through Free Legal Aid Cell. exchange of scientific knowledge and pursuit of Dual PhD courses for medical graduates and non-medical students. The During the year 2014-15, over 5 lakh patients from various process of networking with various other foreign universities parts of the country and across the globe sought medical care across the globe in the field of Mental Health and Neurosciences for psychiatric and neurological problems. About two-third of is actively being pursued. the patients were provided with specialised medical care at no cost or at highly subsidized costs. Attempts are being made During the year, 14 professionals completed Post-Doctoral to integrate extension services activities into “Manasadhara” Fellowship (Acute Care and Emergency Psychiatry - 1, scheme and “Manochaitanya Super-Tuesday” programme Addiction Medicine - 2, Child & Adolescent Psychiatry launched by the Government of Karnataka to provide free - 1, Community Mental Health - 1, Consultation Liaison treatment, counselling and medicines to people suffering from Psychiatry - 1, Neuroanaesthesia - 2, Neurological mental disabilities in rural to semi-urban areas. Rehabilitation - 2, Neurology (Epilepsy) - 1, Neuropathology - 2, Psychosocial Support in Disaster Management - 1) and Particulars 2013-14 2014-15 27 completed PhD (Biophysics - 3, Biostatistics - 1, Clinical Screening 1,06,227 1,13,135 Psychology - 6, Neurochemistry - 4, Neurophysiology - 1, Registrations 56,606 54,710 Psychiatry - 1, Psychiatric Social Work - 9, Speech Pathology Follow-ups 2,18,596 2,42,110 & Audiology - 2); 151 candidates were declared qualified to Admissions 16,631 17,227 receive degrees in various specialties: DM (Neurology), DM Discharges 15,048 14,801 Emergency Care 38,516 44,543 Neuroimaging & Interventional Radiology, DM (Child Deaths 741 689 & Adolescent Psychiatry), DM (Neuroanaesthesia), MD Extension Services* 30,041 25,397 (Psychiatry), M.Ch (Neurosurgery), Diploma (Psychiatry), Total 482406 512612 MPhil, MSc, BSc Degrees, Post-Basic Diploma and Diploma *Outreach Centres = Gunjur – 2394, Gowribidanur – 5772, Maddur – 2740, Kanakapura – 2456, Madhugiri – 2175, Sakalawara – 9398, Turuvekere – 462 in Nursing.
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Sl. Total No. 4 December 2014. Five international speakers from Germany Course No of Students took part in the event. 1 Post-Doctoral Fellows 14 Ph.D. a) Joined the Institute during the year 2014-15 2 35 b) Completed and declared qualified during the year 27 2014-15 Postgraduate degree/diploma and undergraduate a) Joined the Institute during the year 2014-15 3 241 b) Completed and declared qualified during the year 151 2014-15 4 Short-term training (from outside institutions) 6566
A total of 6566 students from various other institutes – from India and abroad – visited NIMHANS and underwent training The first TS Srinivasan-NIMHANS Knowledge Conclave during the year. (Autonomic Dysfunction—An Interdisciplinary Workshop for Clinicians and Scientists) was organised by the Departments of 2.2 Capacity building and strengthening human Neurology and Neurophysiology, NIMHANS, in association resource development with Neurosciences India Group at NIMHANS Convention Centre on 12-13 February 2015. The event was fully supported Through continued knowledge and skills development by generous donation from TVS Foundation, Chennai and this programmes, NIMHANS supports a vibrant culture of will continue in the years to come. initiative and innovation, building leadership and capacity in scholarship and professional practice. Facilitating capacity The details of the other scientific deliberations and conferences building and strengthening human resource development in organised by the Institute are provided separately in the different health care delivery systems form the prime mandates respective section. of NIMHANS. The institute is actively involved in imparting advanced technical knowledge to medical, para-medical and Fifty five new faculty positions (Additional Professors-2; Associate nursing professionals to promote skills and evolve employable Professors-4; Assistant Professors-49) have been created, taking manpower to meet the needs of the nation. Training is also the total number of faculty members to 237. A total of 14 extended to caregivers, police personnel, media persons, positions for the newly opened MR PET facility (Faculty posts-4; administrative medical officers among others. In addition Technical-10) and 96 posts under the non-faculty group (Staff to the short-term training programmes, faculty, staff and Nurses, Clinical Psychologists, Speech Therapist, Physiotherapist, students of NIMHANS routinely conduct and participate in Technicians, etc.) have also been created. various seminars, workshops, conferences and other academic endeavours both within and outside the Institute. All the four laboratories — Neuropathology, Neurochemistry, Neurovirology and Neuromicrobiology — have been accredited During the year NIMHANS hosted several international and by NABL, India. national scientific deliberations. The faculty of the Institute organised 265 educational/ resourceful events (workshops / symposia / conferences: 179 at NIMHANS and 86 outside the 3. Research Institute). A total of 32 faculty members underwent specific training to expand their knowledge horizon. NIMHANS has earned a high reputation for the wide- The Department of Neurosurgery organised NEUROVASCON reaching impact of its multi-disciplinary research activities. 2014, the 14th Annual Conference of Cerebrovascular Society of With the strong public mission and a passion for partnership, India at NIMHANS Convention Centre, from 5-7 September NIMHANS has established an unparalleled stage for 2014. An Indo-German Workshop was conducted by the research in the field of mental health and neurosciences. The Department of Neuroimaging & Interventional Radiology on advanced research at NIMHANS has been facilitated by active
National Institute of Mental Health and Neuro Sciences 11| Annual Report 2014-15 collaborations with several prominent regional, national and neuroinfections and neurological diseases. To enable free and international agencies. The thrust areas of research include: accelerated interaction between NIMHANS clinicians and a) unraveling the molecular and sub-cellular mechanisms IOB scientists, the Institute has allocated Bioinformatics and for disease process, b) linking clinical status with structural, Proteomics Laboratory to IOB at the Neurobiology Research biochemical, immunological and serological abnormalities Centre, NIMHANS. searching for biomarkers, c) exploring genetic basis for disease causation, d) developing prognostic and clinical predictors and diagnostic inventory/checklists. 4. New Initiatives – New Facilities
The institute, during the year 2014-15, kept the momentum 1.1 Memorandum of Understanding (MOU) going with various new projects and initiatives. A total of 723 scientific articles/communications were published (404 articles 1. A Memorandum of Understanding was signed with in International Journals, 191 in National Journals, and 128 Shibulal Foundation on 26 June 2014 for providing other publications including monographs, manuals, chapters in financial aid to needy children who require clinical care. books, articles in newspapers, etc.). The maximum amount being Rs. 40,000/- per patient with a ceiling of Rs. 7,000/- per day. RESEARCH PUBLICATIONS 2. A MOU was signed on 5 July 2014 with the Graduate School of Medicine and Faculty of Medicine Osaka City University, Japan to encourage direct contact and co- operation between the two institutions.
RESEARCH PROJECTS
Dr. P. Satishchandra with Shri. Venu Srinivasan, Chairman and Managing Director, TVS Motor Company and Sundaram Clayton Ltd.
3. A MOU was signed between NIMHANS and Sundaram-Clayton Limited (SCL) on 18 July 2014. SCL has agreed to support and fund various academic programmes/activities of the Institute.
4. NIMHANS and The Johns Hopkins University, USA Advanced Mass Spectrometer Facility (Orbitrap Fusion entered into a MOU on 25 August 2014. The MOU Tribrid Mass Spectrometer) for Clinical Proteomics was sets down the mutually agreed broad framework for inaugurated by Shri. S.R. Patil, Hon’ble Minister for Planning joint research and academic activities in various fields of and Statistics, IT, BT, Science & Technology, Government of interest between the Institutes. Karnataka on 12 August 2014. NIMHANS and Institute of Bioinformatics (IOB) have collaborated to utilise advanced 5. NIMHANS inked a pact with Deakin University, genomic and proteomic platforms for molecular profiling of Victoria, Australia on 7 November 2014 to establish
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cooperative relationship with the aim of developing and bed facility for women with substance use disorders. fostering academic links between the two institutions. This centre will offer personalised care in the form of medications, counselling, family interventions, and other client-based services. The Drug Toxicology Laboratory is fully equipped to carry out chemical tests to monitor drug abuse in patients with addiction and/or psychiatric disorders. It has standardised 20 different screening tests and HPTLC (High Performance Thin Layer Chromatography), GCMS (Gas Chromatography-Mass Spectroscopy), ELISA based analysis of different ‘drugs of abuse’.
NIMHANS faculty members with the team from Deakin University
6. NIMHANS signed a MOU with the Swiss Tropical Institute, Geneva on 17 November 2014 to facilitate interdisciplinary public and global health research, training and capacity building, and media and mental health events.
Dr. Harsh Vardhan, Hon’ble Minister of Health and Family Welfare, Government of India and President inaugurating Centre for Addiction Medicine Complex. Shri. U.T. Khader, Minister for Health and Family Welfare, Government of Karnataka and Dr. Sharan Prakash R. Patil, Hon’ble Minister for Medical Education, Government of Karnataka and Vice-President, NIMHANS are seen
Virtual Knowledge Centre has been established for the
NIMHANS faculty members with the team from Swiss Tropical Institute, use of multipoint video-conferencing, and transmitting Geneva training sessions to various centres across India and South East Asian Countries. 1.2 Enhanced Patient Care Services
1. Centre for Addiction Medicine Complex encompassing Women’s Treatment Wing, Drug Toxicology Laboratory and Virtual Knowledge Centre was inaugurated by Dr. Harsh Vardhan, Hon’ble Minister of Health and Family Welfare, Government of India and President, NIMHANS during his maiden visit to the Institute on 16 August 2014. Shri. U.T. Khader, Minister for Health and Family Welfare, Government of Karnataka and Dr. Sharan Prakash R. Patil, Hon’ble Minister for Medical Education, Government of Karnataka Shri. Jagat Prakash Nadda, Hon’ble Union Minister for Health & Family and Vice-President, NIMHANS were the Guests of Welfare, Government of India inaugurating Digital Subtraction Angiographic Honour. Women’s Treatment Wing is an exclusive 20- (DSA) facility
National Institute of Mental Health and Neuro Sciences 13| Annual Report 2014-15
2. To facilitate efficient and advanced diagnostic imaging 6. NIMHANS Centre for Well Being (NCWB) started facilities, a state-of-the-art Digital Subtraction a new clinic for youth: Window to Well Being—A Angiographic (DSA) facility was inaugurated on 28 clinic for the Youth. This clinic provides interventions December 2014. Shri. Jagat Prakash Nadda, Hon’ble for various difficulties faced by youth including stress Union Minister for Health & Family Welfare, related to academics, relationships, emotional problems Government of India, inaugurated the facility in the (depression, anxiety, adjustment problems, etc.), self- presence of Dr. Sharan Prakash R. Patil, Hon’ble Minister esteem issues, self-harming behaviors, suicidal thoughts for Medical Education, Government of Karnataka. or acts, etc. The team in the clinic liaises with the parents to improve their relationships and bridge the 3. State-of-the-art MR PET Scan Center, first of its kind in generation gap with youth. The clinic also provides the public sector, was inaugurated by the Hon’ble Prime training for counselors and teachers working with youth Minister of India, Shri. Narendra Modi on 18 February in understanding about their psychological problems and 2015, during the 19th Convocation of NIMHANS. The building coping skills. advanced center, set up at a cost of Rs. 40 crore, enhances diagnoses of various complex neurological and psychiatric 7. Owing to the increase in the number of admissions of disorders, giving information about both anatomical and elderly patients to the hospital, geriatric inpatient facility functional details of the brain in real time. has been expanded. Male and female elderly wards— remodeled in the existing adult psychiatry wards with five beds in each ward—has been opened.
8. Portable ultrasound machine for diagnostic procedures especially central venous cannulation, transthoracic echocardiography, transcranial Doppler, peripheral vascular Doppler and abdominal ultrasound both in the operation theatre and neuro-intensive care has been added.
9. Heart Rate Variability (HRV) monitors for autonomic nervous system; Near Infrared Spectroscopy (NIRS) for cerebral oxygenation; Video Laryngoscope for visualisation and intubation; Transoesophageal MR PET Scan Center, first of its kind in the public sector, was inaugurated by the Hon’ble Prime Minister of India, Shri. Narendra Modi echocardiogram in the operation theatres and ICU have been added to the surgical facilities. 4. Two new priority wards called SAFER (Safety and Facilitating Early Recovery) and ASIST (Applied 10. Modern ventilators and newer modes of ventilation like Suicide Intervention, Support and Treatment) for NAVA have been installed. patients with chronic suicidal and violent behaviour have been initiated by the Emergency Psychiatric Services 11. All the OTs are now equipped with state-of-the-art Team, Department of Psychiatry. fumigation and OT sterilization equipment. Noninvasive cardiac output monitors (NICOM) are being used during 5. The special clinical services of the Schizophrenia surgery and ICU to estimate the changes in various Clinic and the Metabolic Clinic have been integrated neurological conditions. to formulate Individualized Schizophrenia Treatment and Reintegration (InSTAR) programme, to ensure a 12. Work towards the establishment of Neuro-ophthalmic personalized clinical approach towards understanding Unit is in progress. This will add a new dimension to and treating individuals with schizophrenia and related the existing facilities for neurological investigation and psychoses. evaluation.
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13. Self-Sustaining Diagnostic Facility: Several new merry-go-round to provide vestibular stimulation, validated tests with enhanced sensitivity and specificity different sensory reeducation boards with various have been developed which provide high precision textures and sand pit to provide tactile stimulation and in clinical diagnosis, facilitating accurate treatment therapy ball to provide proprioceptive input. These and early detection. Such services have tremendous activities are used to improve the interaction of children impact on management as they economize additional with others, develop gross and fine motor skills, hand to investigations, direct specific therapy and also reduce eye coordination, emotional development, concentration, hospital stay. However, most of these tests are unavailable organization, turn-taking and calming which in turn or expensive and unaffordable to our patient clientele improves their functions in daily activities. who are from middle and lower socioeconomic status. Keeping this in mind, Self-Sustaining Diagnostic Facility — a new initiative for providing advanced diagnostic tests in neuromuscular and neuroimmunological disorders and CNS tumors including molecular testing for neuronfections and genetic disorders from the Neuromuscular, Neuro-oncology, Molecular Biology and Genetics Laboratories in Neurobiology Research Centre — has been started with support from the administration in the form of a seed grant and is running successfully benefitting number of patients.
14. A new electrophoresis system has been installed in Multi-sensory Unit in Occupational Therapy Section, Department of the Clinical Pathology and Hematology Section. Neurological Rehabilitation Hemoglobin and Protein electrophoresis tests will soon be initiated. 18. The Department of Speech Pathology & Audiology during the reporting year has started a new initiative— 15. Micro Dialysis System was procured and standardized the auditory rehabilitation of persons with Primary for collecting tissue-fluid samples in freely moving rats in Auditory Neuropathy (Auditory Neuropathy Spectrum animal experimentation. Disorder) in which the interventions are tailor-made to the individuals. 16. Multichannel Electrode Array (MEA) System, a state-of- the-art facility for in vitro electrophysiology laboratory, is 19. The Sakalawara Community Mental Health Center has being established in Neurobiology Research Centre. This been serving as the public laboratory for the National system can be utilized for testing the functional viability Mental Health Programme and other community mental of the neurons from primary cell culture/stem cells/neural health activities for over three decades. During the year cell lines through electrophysiological recordings. under review, the campus and other facilities including cottages and therapy center have been renovated as 17. Multi-sensory Unit has been established under a residential facility to house about 40 patients and Occupational Therapy Section, Department of their family members for short-term rehabilitation Neurological Rehabilitation to provide training to programmes—when they come out of acute problems children with autistic spectrum disorder, attention and require longer stay in the hospital. deficit hyperkinetic disorder and many others. Sensory integration therapy is the neurological method of 4.3 Outreach/Public Education and Extension processing and integrating sensory information from Activities/ Awareness Programmes body and environment which contributes to emotional regulation, learning behavior and participation in daily 1. Centre for Public Health (CPH): In accordance with life. There are various activities like vestibular swing, its mandate, CPH undertook several operational
National Institute of Mental Health and Neuro Sciences 15| Annual Report 2014-15
research activities in key public health areas including Vice-Chancellor of NIMHANS on 23 April 2014. road traffic injuries, harms to others from alcohol use, The first floor houses ‘Mindspace’, a space for academic drugs and logistics and development of a manual for programs and workshops and ‘Knowledge Nook’, a library training of community health personnel, during the and information space for mental health and preventive year. Various training programmes for health personnel neurology that is open to general public. were undertaken to improve service delivery for mental, behavioural and substance use disorders. As of 31 ‘The Loudspeaker – Amplifying the voice of mental March 2015, medical officers from various Primary health’, a mental health magazine for general public Health Centres at Kolar were trained and the training was launched by NCWB on 30 December 2014 at an of community health workers has been initiated. Focused event organised to observe ‘International Day of Persons initiatives were undertaken with respect to assessment of with Disabilities’. Chief Guest of the event Smt. Meera industrial health systems and services within the district. C Saksena, Acting Chairperson, Karnataka State Human Rights Commission, released the first issue ‘Yuva Spandana’ project aimed at providing health of the magazine on the occasion. ‘The Loudspeaker’ promotion services for youth anchored by District Youth is a quarterly magazine packed with up-to-date and Empowerment Centres was taken up in 10 districts cutting-edge features on mental health care. Printing of Karnataka. Around 142 sensitization programmes and publishing of the magazine is funded by Dr. reaching 14,000 youth spread across 10 districts were Ramachandra N Moorthy Foundation for Mental Health conducted. and Neurological Sciences. NCWB brought out one information booklet on Child sexual abuse in Kannada 2. NIMHANS Centre for Well-Being (NCWB): The centre has titled ‘Namage kelisikolluva reethi gotthidhare maathra!’ started a new clinic for youth: Window to Well Being—A Faculty members from Psychiatry and Clinical Psychology clinic for the Youth. This clinic provides interventions departments associated with the centre developed 5 IEC for various difficulties faced by youth including stress leaflets on mental health related topics. The centre in related to academics, relationships, emotional problems collaboration with White Swan Foundation launched a (depression, anxiety, adjustment problems, etc.), self- new website for suicide prevention -Gatekeepersindia. esteem issues, self-harming behaviors, suicidal thoughts org, on the event of World Suicide Prevention Day, 10 or acts, etc. The team in the clinic liaises with the September 2014. As part of the International Women’s parents to improve their relationships and bridge the Day celebrations, NCWB distributed about 200 generation gap with youth. The clinic also provides Toolkits for Health Settings on ‘First level Psychological training for counselors and teachers working with youth Intervention for women survivors of intimate partner in understanding about psychological problems and violence’ on 20 March 2015. building their skills. 3. Neuropathology Brain Museum: The Neuropathology Brain Museum (Human Brain Museum) has become a centre of attraction for the students of various colleges and schools and the tourists alike to have a look at the diverse collection of specimens and samples of human brains. During 2014-2015, a total of 2661 students from 33 schools and colleges visited the Brain Museum. In addition, many foreign scientists and dignitaries, who came to NIMHANS for scientific collaboration, visited the Brain Museum and greatly appreciated the unique Inauguration of the first floor at NIMHANS Centre for Well Being collection and the means of display. The Brain Museum was also widely reported in print and electronic media. An additional floor constructed at the NCWB building The total number of visitors to the Neuropathology was inaugurated by Dr. P. Satish Chandra, the Director/ Brain Museum during 2014-2015 stood at 4184, in
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comparison to 3170 during the previous year. The visitor 4. Post-doctoral fellowship course in Transfusion Medicine footfall has been increasing every year owing to the wide has been initiated by the Department of Neuropathology. dissemination of information about the facility in the Two post graduate certificate courses (two-year print, electronic and social media. duration) for technicians have been proposed—one in Neurohistopathology & Electron Microscopy and another in Hematology and Transfusion Medicine Technology to enhance skilled manpower.
5. A one-month full time certificate course for Psychology postgraduates called P3 REACH (Positive Psychology Perspective: Research, Education and Communication for Health) was successfully completed in August 2014. The programme aims at strengthening skills in conceptualizing and conducting research grounded in positive psychological perspective and building capacity to carry out educational and communication activities for mental health promotion in general community. Schoolchildren having a look at the exhibits in the Neuropathology Brain Museum 6. “Virtual Knowledge Network”, an online capacity 4.4 Academic building facility, has been initiated by the Department of Psychiatry to develop and support the skilled mental 1. NIMHANS has started two new super speciality courses, health resources in the country. This was developed DM in Neuropathology and DM in Addiction Medicine, initially in the area of Addiction Medicine/Psychiatry from the academic year 2015-16. Post-Doctoral and has now been extended to seminars and other Fellowship (PDF) programmes have also been started academic programmes of the department. The academic in the areas of Geriatric Psychiatry and Schizophrenia. programmes, beamed across the country, are also available These new and specialised courses will augment the on the web portal. manpower of pre-existing Post-Doctoral Fellows in various subspecialties in both clinical and preclinical 7. Youth Spring website was launched by the Department branches and develop highly trained medical specialists of Clinical Psychology in July 2014 for the purpose of for the country. enhancing youth engagement in social causes, especially mental health and road safety and acknowledging 2. The two-year Diploma in Psychiatry (DPM) programme the efforts being made by the youth themselves. This has been discontinued from 2015. In lieu of DPM was launched as part of an ICSSR funded project on programme, nine more seats have been added to the development of a youth engagement module. The overall three-year MD Psychiatry Course which will commence goal is to work towards enhancing social well-being of from July 2015, as most students who complete the DPM youth. The website receives 1000 plus visitors per month course eventually opt for the MD degree programme. All on an average. Apart from regular monthly updates in the the nine seats are reserved for students from Karnataka various sections (opinion poll, quiz, etc.), e-campaigns (as DPM seats were earlier meant for students from and events are launched using the website on a regular Karnataka only). Fellowship courses in Psychiatric basis. The compilation of narratives received through Rehabilitation and PhD in Mental Health Rehabilitation The Voices of Hope online campaign was brought out in have also been started from the academic year 2014-15 the form of a booklet.
3. PDF Neurocritical care (PDFNCC) course was started 8. Three candidates completed the six-month certificate in July 2014 under the Centre for Advanced Research course in Cognitive Behavioural Therapy (CBT) in May (CAR), which is an ICMR-DHR-sponsored initiative. 2014. The second batch of the course has commenced from
National Institute of Mental Health and Neuro Sciences 17| Annual Report 2014-15
February 2015, in which two candidates have enrolled and proteomic platforms for molecular profiling of and are undergoing training. The course is designed to neuroinfections and neurological diseases. equip clinical psychologists with skills in practicing CBT using hands on training in the Behavioural Medicine 2. The Department of Mental Health Education, Unit of the Department of Clinical Psychology. NIMHANS in collaboration with Directorate of Advertising and Visual Publicity, Government of India 9. The Human Brain Bank, with financial assistance from and media units of other central government agencies ICMR, has prepared an atlas of CNS Infections, copies has begun to promote health education for various of which have been distributed to several medical colleges mental and neurological disorders. Work was initiated by and teaching institutions in the country. An illustrated providing Directorate of Advertising and Visual Publicity, atlas of Neurohistology is under preparation. Government of India H1N1 posters and brochures. These were in turn circulated to various organisations 10. The Department of Psychopharmacology has initiated like ISRO, Doordarshan, DRDO, KIOCL Limited, e-Journal Club with the support of the Indian Psychiatric Central Bank of India, Air India Limited, Central Silk Society; this platform conducts regular teaching activities Board, HMT Limited, etc. Health promotion activities and provides education and guidance on aspects of regarding MNS would be taken up routinely in future. research methodology to postgraduate students and academic psychiatrists in India. 3. A Disaster Recovery (DR) Centre has been set up (behind the Library and Information Centre at the 11. Psychiatric Rehabilitation Services, Department Administrative Block) to protect critical data of patients of Psychiatry has started Journal of Psychosocial in the event of a natural disaster or other emergency that Rehabilitation and Mental Health, from June 2014. causes downtime of the Data Centre. The centre runs on 10 Gbps bandwidth connectivity to critical departments 4.5 New Initiatives like Emergency, OPD, Neurocentre and other laboratories which are patient data intensive. The centre is equipped with Modular Safe, a state-of-the-art technology of IP56 and F90 standard, to ensure protection from fire, water and dust in a cost effective manner.
4. CCTV services in the OPD have been replaced by Digital Signage—a form of electronic display that shows images, videos, information, etc. on display systems. The customized content is transmitted to the screens through the internet and centrally programmed and monitored centre.
5. The renovated Kabini hostel meant exclusively for Shri. S.R. Patil, Hon’ble Minister for Planning and Statistics, IT, BT, Science married residents was reopened on 4 July 2014. Forty & Technology, Government of Karnataka inaugurating Advanced Mass Spectrometer Facility for Clinical Proteomics eight family rooms are now available in this building (with single room facility). 1. Advanced Mass Spectrometer Facility (Orbitrap Fusion Tribrid Mass Spectrometer) for Clinical Proteomics was 6. As per the Government of India guidelines for public inaugurated by Shri. S.R. Patil, Hon’ble Minister for sector institutions, NIMHANS has introduced electronic Planning and Statistics, IT, BT, Science & Technology, attendance systems, where the manual entries into the Government of Karnataka on 12 August 2014. registers have been replaced by electronic-attendance NIMHANS and Institute of Bioinformatics (IOB) marked through biometric systems and smart-cards. have collaborated to utilise cutting-edge genomic These systems have allowed easy compilation and
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scrutiny of attendance data leading to better supervision and monitoring. New ID cards (Aadhaar-linked smart cards) have been issued to all the employees of the Institute.
5. Recognition for NIMHANS Contributions
5.1 Awards Dr. P Satishchandra, Director/Vice-Chancellor, NIMHANS receiving the Karnataka Rajyotsava Award from the Hon’ble Chief Minister of Karnataka Shri. Siddaramaiah
3. NIMHANS secured an award under the Technology in Testing and Assessments in Higher Education Institutions Project category (for high quality conducting computer-based examinations) at the World Education Summit 2014. Dr. Umamaheswara Rao, Senior Professor of Neuroanaesthesia, received the award on behalf of the Director of NIMHANS at New Delhi, 8 August 2014.
4. NIMHANS was accorded the prestigious Times of India & New India Assurance-Healthcare Achievers Award Dr. K. Lalitha, Professor & Head, Dept. of Nursing, NIMHANS receiving the 2014 under ‘The Best Hospital in Single Specialty— prestigious National Florence Nightingale Award from the Hon’ble President of India Shri. Pranab Mukherjee at the Rashtrapati Bhavan, New Delhi Neurology’ category. The Director/Vice-Chancellor of NIMHANS received the award at a function held at 1. Dr. K. Lalitha, Professor & Head, Dept. of Nursing, New Delhi on 11 December 2014. NIMHANS received the prestigious National Florence Nightingale Award from the Hon’ble President of India 5. NIMHANS was honoured with the “Namma Bengaluru at the Rashtrapati Bhavan, New Delhi on the occasion of Award” under the Government Organisation Category International Nurses Day 2015. The Award carries Rs. as a tribute to the Institute’s spirit of service and 50, 000/- cash, a citation certificate and a medal. commitment to citizens of Bengaluru.
2. Dr. P Satishchandra, Director/Vice-Chancellor, 6. Dr. Rita Christopher, Professor & Head, Department NIMHANS was conferred the coveted Karnataka of Neurochemistry, NIMHANS, received “Centre Rajyotsava Award (the second highest civilian honour of of Excellence in Science, Engineering & Medicine the Karnataka state) by the Government of Karnataka for (CESEM)” Award for the year 2014-15 from Vision the year 2014 for his contribution to the field of medicine. Group on Science & Technology (VGST). The grant has The Director/Vice-Chancellor also received Professor been sanctioned for the purpose of establishing Centre D.K. Bachhawat Life Time Achievement Award by the for Excellence in “Identification of circulating miRNA Indian Academy of Neurosciences and delivered a lecture signature for diagnosis of cerebral small vessel disease.” on “Bridge over Troubled Water”, at the International Symposium on Translational Neurosciences & XXXII 7. Dr. BS Shankaranarayana Rao, Professor, Department Annual Conference, 1 November 2014. of Neurophysiology, received (i) KT Shetty Memorial
National Institute of Mental Health and Neuro Sciences 19| Annual Report 2014-15
Oration for the outstanding contributions to neurosciences Sociology-2014 (International Institute for Social and from the Indian Academy of Neurosciences (IAN), Economic Reforms, Chanakyapuri, New Delhi) 2 November 2014 (ii) Krantiveera Sangolli Rayanna Award in recognition of outstanding contributions and 5.2 Oration by NIMHANS Faculty excellence in the field of Medical Sciences by Karnataka State Mandahaasa Organization, Bangalore, 9 November 1. Dr. P. Satishchandra, Director/Vice-Chancellor, 2014 (iii) Sri Jayachamarajendra Wadeyar Award for NIMHANS, delivered (i) Foundation Day Oration, outstanding contributions and excellence in the field of ‘Ageing and Dementia—Can This Be Prevented’, Neuromedicine and for extraordinary achievement and Geriatric Mental Health Unit, King George’s Medical yeoman services rendered to the country, the award was University, Lucknow, 22 August 2014 (ii) Dr. K. Chaya presented at Kannada Bhavana, Bangalore, 18 April 4th Memorial Oration, ‘Practical approach on how to 2014. prevent aging of brain and dementia’, IMA, Vijayawada, 2 November 2014. (iii) the Presidential Oration, ECON 8. Dr. Dhananjay I Bhat, Additional Professor, Department 2015, ‘Translational Research in Epilepsy: Indian of Neurosurgery, received Alfred Trauma Research Perspective’, Chennai, 6-8 February 2015. Development Award 2014-15 (instituted by Alfred Hospital, Sydney, New South Wales, Australia 2. Dr. SK Shankar, Emeritus Professor of Neuropathology, Neurotrauma Society) for paper presentation, ‘Validation Prof. LN Mohapatra Oration, ‘Pathobiology of Common of a blast induced neurotrauma model using modified Fungal Infections of Brain’, APCON – 14, Bhubaneswar, Reddy tube in rats: A pilot study’. Odisha, 14 September 2014.
9. Dr. Dhaval P Shukla, Additional Professor, Department 3. Dr. Vani Santosh, the Cochin Neurological Society of Neurosurgery, second prize for poster presentation, Oration, ‘Understanding Malignant Gliomas in the Era of ‘Photo Atlas of Skull Base using DSLR Camera, 16th Biomarkers’, Neurological Society of India – Kerala Chapter Annual Conference of Skull Base Surgery Society of (NSIKC), Trivandrum, 28 February – 1 March 2015. India, JIPMER, Puducherry, 9-12 October 2014. 4. Dr. Pramod Kumar Pal, Professor, Department 10. Dr. Shivaram Varambally, Associate Professor, of Neurology, Dr. S. Janaki Memorial Oration, Department of Psychiatry, received Dr. Vimla Virmani ‘Understanding the pathophysiology of Spinocerebellar Award of the NAMS (India) for the year 2014, for paper Ataxias through Genetics, Neurophysiology, Structural presentation, ‘Therapeutic efficacy of add-on yogasana and Functional Neuroimaging’, 54th Annual Conference intervention in stabilized outpatient schizophrenia: of the National Academy of Medical Sciences, Rishikesh, randomized controlled comparison with exercise and 18-19 October 2014. waitlist’, NAMSCON, AIIMS Rishikesh, 18-19 October 2014. 5. Dr. SK Chaturvedi, Professor, Department of Psychiatry, The Department of Psychiatry Foundation Day Oration, 11. Dr. Nandakumar DN, Associate Professor, Department ‘Tumour in body, cancer in mind’, King George’s Medical of Neurochemistry, received ISNO Award 2015, ‘Best University, Lucknow, 21 March 2015. Researcher in Basic/Translational Research in Neuro- oncology, 7th Annual Conference of the Indian Society 6. Dr. Mathew Varghese, Professor, Department of of Neuro-Oncology (ISNO), Kochi, Kerala, 26-29 Psychiatry, 3rd Dr. Shiv Gautam Annual Oration of the March 2015. Indian Association for Geriatric Mental Health Kolkata, ‘Prevention in Geriatric Psychiatry’, GERON 2014, 12. Dr. R Dhanasekara Pandian, Associate Professor, September 2014. Department of Psychiatric Social Work, Dr. Abdul Kalam Life Time Achievement Award for remarkable 7. Dr. Chittaranjan Andrade, Professor, Department of achievements in Teaching and Publications in Psychopharmacology, (i) HJ Mehta Oration, ‘Electrical
20 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Stimulation of the Human Brain: Clinical and Basic Science Findings’, St. John’s Medical College, July 2014, Bangalore (ii) Dr. UK Sheth Oration, Seth G.S. Medical College and KEM Hospital, Mumbai, January 2015
8. Dr. V Ravi, Professor, Dr. NC Ananthakrishna Endowment Lecture, ‘Virology-Paradox of Our time’, CME on Virology, Kasturba Medical College, Mangalore, 28 March 2015.
ctivities and vents at imhans 6. A E N Chief Guest of International Nurses Day 2014 function Prof. Lt. Gen. D. Raghunath, Retd. Director General, Armed Forces Medical Services being felicitated
Dr. B.R. Ambedkar Jayanti Awards for Best Staff Nurse and Best Wards (psychiatric and neuro wings) were presented on the occasion. Staff Nurses Bharat Ratna Dr. B.R. Ambedkar Jayanti was celebrated on 30 Smt. Soya (Pavilion 1), Smt. Jessima Mani (NIIR) and Smt. April 2014 at NIMHANS. Sridevi (Casualty) bagged the Best Nurses Award for 2013-14. The Best Ward Award was secured by Pavilion 3 and NICU. Venerable Bhante Ananda, General Secretary, Maha Bodhi Florence Nightingale Award instituted by C. Krishnaiah Society, Bangalore was the Chief Guest. Dr. B.V. Rajaram, Chetty & Sons Foundation, Bangalore, carrying cash prize eminent theatre personality and social activist was the Guest of Rs.5000, was given to Mrs. Fiona Mariola D’Mello, Staff of Honour. Folk artistes from Drama & Arts Division of Nurse of NSICU. Kendriya Sadan, Bangalore performed ‘Kamsale’, the art form of Karnataka on the occasion of Dr. Ambedkar’s 123rd birth Dr. Sailaxmi Gandhi, Assistant Professor of Nursing, who anniversary celebrations. received the prestigious National Florence Nightingale Award from the Hon’ble President of India at the Rashtrapati Bhavan, New Delhi was felicitated on the occasion of Nurses Day 2014.
Mrs. H. Dorothy Paripoornam, Staff Nurse, who received the State Florence Nightingale Award by the Hon’ble Chief Minister of Karnataka at Vidhana Soudha, Bangalore was felicitated.
Guest Lecture on White Swan Foundation for Mental Health
Venerable Bhante Ananda, General Secretary, Maha Bodhi Society, Bangalore and Dr. B.V. Rajaram, eminent theatre personality and social activist, at Dr. B.R. Ambedkar Jayanti celebrations
International Nurses Day 2014
The International Nurses Day was celebrated on 12 May Mr. Subroto Bagchi, co-founder and Chairman of Mindtree Limited 2014 under the theme “Nurses: A Force for Change - A Vital Resource for Health”. Prof. Lt. Gen. D. Raghunath, Retd. Mr. Subroto Bagchi, co-founder and Chairman of Mindtree Director General, Armed Forces Medical Services was the Limited, delivered a special lecture on White Swan Foundation Chief Guest. for Mental Health, its mission, vision and activities carried out
National Institute of Mental Health and Neuro Sciences 21| Annual Report 2014-15 by the foundation on 21 June 2014 at Administrative Block Independence Day (Lecture Hall I), NIMHANS. Independence Day was celebrated with patriotic fervor and Mr. Bagchi highlighted the motivation for the launch of White gaiety on 15 August 2014. Hoisting of the Tricolour by Prof. P. Swan Foundation and recalled his keynote address as the Chief Satishchandra was followed by colourful cultural programmes Guest at the Institute Day celebrations of the NIMHANS. by the students of NIMHANS College of Nursing and inmates He called upon mental health professionals and others to of various wards of the hospital. empower people with the right knowledge so that they can make informed decisions on the occasion.
Academic Committee Meeting
The first Academic Committee meeting of NIMHANS, as an Institute of National Importance, was held under the Chairmanship of Dr.Vijayaraghavan, Secretary DBT on 19 July 2014. Two new DM Courses in Neuropathology and Addiction Medicine were approved by the Committee in the meeting.
World Brain Day Independence Day celebrations World Brain Day was observed at NIMHANS on 22 July 2014. The Department of Neuropathology and Human Brain Teachers’ Day Museum (Brain Bank) organized an interaction programme for schoolchildren, as part of the celebrations. Around 150 students Teachers’ Day was celebrated on 5 September 2014. Dr. from two schools participated in this event. The Director/ Mahabaleshwara Maiya, former Professor of Medicine, Vice-Chancellor of NIMHANS addressed the gathering and Karnataka Government Service and Consultant, Maiya stressed the importance of awareness and prevention of several Multispeciality Hospital, was the chief guest of the event. Dr. neurological disorders. The Department of Nursing also Maiya delivered a special talk on ‘Good Teacher - Where is he?’ organized an awareness programme and exhibition for public in the OPD on the occasion.
Dr. Mahabaleshwara Maiya, former Professor of Medicine, Karnataka Government Service and Consultant, Maiya Multispeciality Hospital at the Teachers’ Day celebrations
Keeping with the Teachers’ Day tradition, senior faculty members of NIMHANS were honoured for their contributions to the growth of the Institute. Retired faculty Dr. M. World Brain Day celebrations Venkataswamy Reddy, Additional Professor, Department of
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Biostatistics, NIMHANS and Dr. Nagarajaiah, Additional Satishchandra, Director/Vice-Chancellor, NIMHANS, was Professor, Department of Nursing were felicitated on the the Guest of Honour. A walkathon to sensitise the general occasion. community about the theme of World Mental Health Day (Living with Schizophrenia), was flagged off by Shri. DK Children’s Day Ravi, Deputy Commissioner, Kolar District, Dr. Fayaz Khan, District Health Officer, Kolar and Dr. G Gururaj, Professor Children’s Day was celebrated with gusto by the Department of and Head, Department of Epidemiology, NIMHANS. A Child and Adolescent Psychiatry and NIMHANS Gymkhana short play on the theme was also performed on the occasion. on 14 November 2014. ‘Swachh Bharat’ Mission Children from Psychiatry ward showcased their talents in the cultural programmes organised by the Department of Child and ‘Swachh Bharat’ Mission, the ambitious cleanliness drive, Adolescent Psychiatry, making the day a memorable occasion. was launched on 2 October 2014, commemorating the birth Awards and notebooks were handed over to meritorious anniversary of Mahatma Gandhi. children of the Institute staff by Prof. P Satishchandra, Director/Vice-Chancellor, NIMHANS. Prizes to the winners Prof. P Satishchandra, Director/Vice-Chancellor, NIMHANS of various competitions held as part of the Children’s Day flagged off the mission by administering the ‘swachta’ celebrations were also distributed on the occasion. (cleanliness) pledge to the faculty and staff of the Institute. Equipped with brooms and dustbins, faculty and staff of NIMHANS came together to clean the Institute campus.
Floral tributes were also paid to the portrait of Mahatma Gandhi on the occasion of the birth anniversary of the Father of the Nation.
Children’s Day celebrations
World Mental Health Day
Release of District Mental Health Systems, Health Resources, Health Management Information System and Information Education Communication Reports on the occasion of World Mental Health Day at Kolar
NIMHANS celebrated World Mental Health Day at Kolar on 10 October 2014. The event was organised in association with District Administration Kolar, the District Legal Services Authority, and District Health and Family Welfare Office.
Shri. UT Khader, Minister for Health and Family Welfare, Government of Karnataka was the Chief Guest and Dr. P NIMHANS faculty and staff taking part in the cleanliness drive
National Institute of Mental Health and Neuro Sciences 23| Annual Report 2014-15
Karnataka Rajyotsava As part of the Lamp Lighting Ceremony celebrations, students and trainees lit the lamp symbolising their dedication to the Karnataka Rajyotsava was celebrated with fervour on 24 profession, and took an oath to serve humanity with compassion November 2014 at the Institute. Shri. Y.V. Gundurao, noted and empathy. theatre actor and director (of Hasyotsava fame) and personality development trainer, was the Chief Guest at the function. Hindi Week Valedictory
Children of Yaksha Kala Academy, under the direction of Valedictory Function of the Hindi Week Celebrations 2014 Yakshagana exponent Shri. Krishnamurthy Tunga, gave a was held on 24 December 2014. Smt. Subbalakshmi G.R, sublime presentation of “Veera Abhimanyu” and held the Chief Manager (OL Division), Vijaya Bank (Head Office), audience spellbound. Bengaluru was the Chief Guest.
Prizes to the winners of various competitions held as part of the Hindi Week Celebrations and certificates (of attendance) to the participants of the Hindi Workshop 2014 were distributed on the occasion.
Children of Yaksha Kala Academy performing at a function organised to celebrate Karnataka Rajyotsava
Graduation Day and Lamp Lighting Ceremony
The first Graduation Day and ninth Lamp Lighting Ceremony Smt. Subbalakshmi G.R., Chief Manager (OL Division), Vijaya Bank at the were held on 29 November 2014. Dr. Yogesh Chawla, Director, Valedictory Function of the Hindi Week Celebrations 2014 Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, Chief Guest of the event, conferred International Day of Persons with Disabilities the degrees on the successful candidates and delivered the Graduation Day Address. Meritorious students received awards from the Chief Guest and other dignitaries.
Dr. Yogesh Chawla, Director, Postgraduate Institute of Medical Education & Release of various educational materials by the Chief Guest Smt. Meera Research (PGIMER), Chandigarh, at the First Graduation Day and Ninth Lamp C. Saxena IAS (Retd.), Acting Chairperson, Karnataka State Human Rights Lighting Ceremony Commission, Bengaluru
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International Day of Persons with Disabilities, under the theme Jagat Prakash Nadda, Hon’ble Union Minister for Health “Sustainable Development: The Promise of Technology”, was & Family Welfare, Government of India & President, celebrated on 30 December 2014. Smt. Meera C. Saxena NIMHANS; Dr. Sharanprakash R. Patil, Hon’ble Minister IAS (Retd.), Acting Chairperson, Karnataka State Human of State for Medical Education, Government of Karnataka Rights Commission, Bengaluru was the Chief Guest. Various & Vice-President, NIMHANS shared the dais with the educational materials were released by the Chief Guest and Dr. Hon’ble Prime Minister. P. Satishchandra, Director/Vice-Chancellor on the occasion.
Institute Day
The 41st Institute Day was celebrated on 13 February 2015. Shri. Venu Srinivasan, Chairman and Managing Director, TVS Motor Company and Sundaram Clayton Ltd. was the Chief Guest. Prof. Dinesh Bhugra, President, World Psychiatric Association and Visiting Professor, NIMHANS, Bengaluru was the Guest of Honour.
Distinguished service awards were presented to selected staff members of the Institute by the Chief Guest. Diploma courses and post-doctoral fellowship certificates were also presented to Hon’ble Prime Minister of India Shri. Narendra Modi delivering the successful candidates on the occasion. Convocation Address
Shri. Venu Srinivasan, Chairman and Managing Director, TVS Motor Company and Sundaram Clayton Ltd. and Prof. Dinesh Bhugra, President, World Psychiatric Association and Visiting Professor, NIMHANS, Bengaluru at the st41 Institute Day celebrations Hon’ble Prime Minister of India Shri. Narendra Modi interacting with schoolchildren at the Convocation
19th Convocation Shri. Sadananda Gowda, Union Minister for Law and Justice and Shri. Ananth Kumar, Union Minister for Chemicals and The 19th Convocation of NIMHANS, held on 18 February Fertilizers were also present on the occasion as the Guests of 2014, turned out to be a historic day and momentous occasion Honour. for the Institute. Hon’ble Prime Minister of India, Shri. Narendra Modi graced the occasion as the Chief Guest and The Hon’ble Prime Minister also inaugurated the MR-PET delivered the Convocation Address. Centre at NIMHANS. Prof. P. Satishchandra, Director/Vice- Chancellor, NIMHANS, presented a brief report highlighting Shri.Vajubhai Vala, Hon’ble Governor of Karnataka; Shri. the various developments and achievements of the Institute Siddaramaiah, Hon’ble Chief Minister of Karnataka; Shri. during the past year.
National Institute of Mental Health and Neuro Sciences 25| Annual Report 2014-15
Condolence Meeting for Prof. RM Varma Public Health. Mrs. Sudha Murthy, Chairman, Infosys Foundation handed over the keys of the new vehicle to the Director/Vice-Chancellor, NIMHANS on 28 August 2014.
2. The Hutti Gold Mines Co. Ltd, Bangalore, donated Rs. 20 lakh for the purchase of EEG equipment (2 nos.) in the hospital, on 10 September 2014.
3. State Bank of Mysore donated a 40-seater bus, worth Rs. NIMHANS faculty and staff paying tributes to Prof. RM Varma 23 lakh, to the Institute on 31 December 2014. Prof. R Marthanda Varma, internationally acclaimed Neurosurgeon, former Director of NIMHANS, and Member, 4. Donations received from other individuals include: Rs. Governing Body, NIMHANS, who visualized and oversaw 1.00 lakh from Mrs.Vanitha Ramaswamy towards patient the amalgamation of the Mental Health Hospital and the All care and US$40,000 from Dr. Jayashree Sundararajan, India Institute of Mental Health into National Institute of Neurologist, The University of Kansas Hospital, towards Mental Health and Neuro Sciences, passed away on 10 March the visit of two students (from the Dept. of Neurology) 2015 after a brief illness at the age of 94. Rich tributes were to Kansas for short-term training. paid to Prof. RM Varma, at the condolence meeting organised by the Institute on 12 March 2015. Various faculty and staff Employees of NIMHANS contributed their one- members of the Institute, professionals who were directly and day salaries, totalling up to Rs. 34 lakh, to the Prime indirectly associated with Prof. RM Varma, met to pay homage Minister’s National Relief Fund. The Prime Minister to the gifted surgeon, practical visionary, and a self-effacing, has appreciated the thoughtful gesture and conveyed genuinely caring human being. his gratitude for the same.
7. Donations 8. Policy Implementation
8.1 Implementation of Right to Information Act
NIMHANS has implemented the Right to Information Act 2005 as per the directions of Central Information Commission, Government of India, and the Ministry of Health and Family Welfare, Government of India. A team of Central Public Information Officers headed by the Registrar of the Institute— who is the Appellate Authority—is responsible for providing information to a person who seeks information under the RTI Act. The Public Relations Officer serves as the liaison officer and handles correspondence with the authorities concerned. On average, the Institute receives 50-60 RTI applications, Mrs. Sudha Murthy, Chairman, Infosys Foundation handing over the keys of the multi-utility vehicle to the Director/Vice-Chancellor, NIMHANS and replies to the queries are sent within the stipulated time. Quarterly returns pertaining to RTI are filed and submitted to 1. Infosys Foundation donated a seven-seater multi-utility Central Information Commission online as per the prescribed vehicle (Bolero) to NIMHANS for use by the Centre for guidelines.
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8.2 Government of India Reservation Policy by focusing on promoting accessibility, as well as removing different types of barriers in the society. NIMHANS functions under the Ministry of Health and Family Welfare, Government of India and follows the 8.4 Official Language Policy reservation policy as laid down by the Central Government for faculty recruitment and student admission. The Official Language Implementation policies and Constitutional provisions (Official Languages Act, 1963 8.3 Persons with Disabilities Act and the Official Languages Rule, 1976) are being strictly implemented at NIMHANS under the guidance of the Reservation to Persons with Disabilities is provided by Department of Official Language, Union Ministry of Health NIMHANS in line with the provisions of the Persons with and Family Welfare, Government of India. Advertisements, Disabilities (Equal Opportunities, Protection of Rights and notifications, name boards, and sign boards are in Hindi and Full Participation) Act, 1995 in various posts and services of English. Hindi courses/classes, Hindi typing and stenography the Institute. NIMHANS is also involved in various activities training are conducted regularly. initiated to remedy the exclusion of persons with disabilities
MoU with TVS Motor Company Ltd. for academic cooperation
TVS Motor Company Ltd., Chennai represented by its Chairman and Managing Director, Mr. Venu Srinivasan, signed a memorandum of understanding (MoU) with NIMHANS to develop and promote academic activities and initiatives in the name of Sri T S Srinivasan. The MoU envisages the following: 1. Creation of TS Srinivasan Chair in Clinical Neurosciences from internationally recognised and accomplished teachers from India and abroad for a period of one to three years. The duration of the chair could be extended up to five years at the advice of Selection/ Review Board. The incumbent will be responsible for post-graduate training and teaching and promote research in any field of clinical neurosciences. A dedicated research fund of Rs. 5 lakh will be offered to the Chair and will be assisted by one Post-Doctoral Fellow (PDF) named after TS Srinivasan on yearly basis. 2. One Post-Doctoral Fellowship in Neurocritical Care 3. Annual PhD bursaries/scholarships of Rs. 1.5 lakh each for five PhD (Clinical Neurosciences) scholars. 4. Organising the TS Srinivasan – NIMHANS Knowledge Conclave at NIMHANS every year with an allocation of Rs. 15 lakh / conclave. The conclave is to be organised in conjunction with the visit of TS Srinivasan Orator to India for the Annual TS Srinivasan Oration along with three other visiting Professors of international renown invited by NIMHANS.
The first TS Srinivasan-NIMHANS Knowledge Conclave, under the theme ‘Autonomic Dysfunction’ was organised by the Departments of Neurology and Neurophysiology, NIMHANS, in association with Neurosciences India Group at NIMHANS Convention Centre on 12 – 13 February 2015. The conclave featured a galaxy of national and international experts in the field of neurosciences. The second TS Srinivasan-NIMHANS Knowledge Conclave is scheduled to be held in February 2016, under the theme ‘Cognitive Neurosciences’.
First TS Srinivasan-NIMHANS Knowledge Conclave
National Institute of Mental Health and Neuro Sciences 27| NIMHANS The Way Forward
I am pleased to state that, our Institution, NIMHANS, enjoys the position of pre-eminence in the country and amongst the professional community due to its legacy, tradition and the collective and continued contribution of several previous Directors, faculty, staff and students over the years. It was a matter of great pride and joy for all of us when NIMHANS was declared an Institution of National Importance in 2012.
Patient care has always received the utmost priority at NIMHANS. Not surprisingly the excellence in standards of patient care has also resulted in designing and developing new model of care and new protocol for management of mental, neurological and substance use disorders. More than 500,000 patients have sought clinical care this year, bearing testimony to our endeavours. Our efforts are conscious and they combine academics and human resource development for health care, so that patients far and wide and across the boundaries of geographies can derive the benefit.
The tradition of starting new courses (DM in Neuropathology and DM in Addiction Medicine) and signing MoU’s (Shibulal Foundation, Bengaluru; Osaka City University, Japan; Sundaram-Clayton Limited; The Johns Hopkins University, USA; Deakin University, Victoria, Australia; Swiss Tropical Institute, Geneva), catalyzing human resources development will continue in the years to come. During the year, apart from the two new DM Courses, Dual PhD courses have been initiated in collaboration with Maastricht University, Netherland and University of Liverpool, UK and nearly 275 scientific deliberations of high value have been conducted both within and outside NIMHANS. This continues to be our benchmarks for our academic achievements year after year.
NIMHANS has acquired the PET-MRI machine, first in any public sector undertaking in the country and we plan to add Cyclotron and many more unique facilities to promote advanced research and enhance patient care. We are looking forward to establishing a comprehensive ‘Sub-specialty Block for Neurosciences’ with 125 hospital beds, special diagnostic facilities and two new OTs in the coming year. Intraoperative MRI Complex with three more state- of-the-art OTs will also be established soon. Separate ‘Adolescent Psychiatry Ward’ with 24 beds will start functioning soon to lay emphasis on ‘youth mental health’.
New independent Department of Transfusion Medicine and Clinical Hematology will start functioning soon.
The NIMHANS experiment of starting specialty centres—Centre for Addiction Medicine, Centre for Well Being, Centre for Public Health, etc.—has been successful with far-reaching effects. This definitely has futuristic implications for growth in the field of psychosocial medicine at NIMHANS and this shall be pursued with greater vigour. I am very happy to share with you that the National Mental Health Survey, the first of its kind in the country, has already been initiated in 12 states and four metros of the country. This landmark activity would be a watershed mark for the country in planning and evolving new policies in mental health and neurological services and promote the implementation of the National Mental Health Programme and the District Mental Health programme, the flagship activities.
While we take pride in recognising that more than 700 scientific communications in international and national journals and other media are published this year, the unique mark of NIMHANS is the cutting-edge research emphasising the translational research. We pledge to scale up these efforts in the years to come. We have forged new partnerships and charted new growth patterns to realise the Vision and Mission of our Institution. While we review our activities, achievements and performance for the year 2014-15, we will set a new pragmatic benchmark for the further growth.
On behalf of the NIMHANS staff and students I would like to declare our continued dedication and commitment for uplifting the underprivileged and neglected sections of our society. I take this opportunity to invite all of you to be stakeholders and partner with us in defining new standards of mental health care for our country.
Dr. P. Satishchandra Director/Vice-Chancellor
Art therapeutic activity in Psychiatric Rehabilitation Services, NIMHANS, Bengaluru (Artwork by Praveen Arora) Sri. J. Ramaiah Smt. M.Jayalakshmi AAO Hospital Assistant DOJ: 06.10.1980 DOJ: 01.04.1982 DOR: 30.04.2014 DOR: 31.04.2014
Smt. Chandramma Smt. B.R. Bhanumathi Yadav Hospital Assistant Senior Librarian DOJ: 24.11.1983 DOJ: 19.06.1982 DOR: 31.04.2014 DOR: 30.04.2014
Staff who served NIMHANS (Retired/Superannuated)
Smt. R.Kowsalya Smt. H. Prema Hospital Assistant Hospital Assistant DOJ: 10.09.1982 DOJ: 06.09.1982 DOR: 31.04.2014 DOR: 31.04.2014
Sri. Y.Thirupal Hospital Assistant DOJ: 14.10.1986 DOR: 31.04.2014 Smt. Sarojamma Dr. V. Shanmugam Hospital Assistant Research Assistant DOJ: 10.09.1984 DOJ: 09.05.1983 DOR: 31.04.2014 DOR: 31.05.2014 Sri. Anwar Sri. R. Shiva Kumar Sri. T. Munirajulu Hospital Assistant Office Assistant Office Assistant DOJ: 15.03.1979 DOJ: 02.11.1983 DOJ: 24.02.1984 DOR: 31.05.2014 DOR: 31.05.2014 DOR: 31.05.2014
Sri. Narasimha Reddy Sri. Shivanna Office Assistant Office Assistant DOJ: 12.03.1984 DOJ: 18.02.1989 DOR: 31.05.2014 DOR: 31.05.2014
Sri. B. Hanumanthaiah Sri. G. Pulla Reddy Smt. N.S. Padmavathi AAO (Adhoc) Sr. M.R.O Steno Gr. I DOJ: 24.12.1981 DOJ: 15.03.1979 DOJ: 02.07.1983 DOR: 30.06.2014 DOR: 30.06.2014 DOR: 30.06.2014
Sri. Chikkathimmaiah Sri. V.Ramachandra Office Assistant Hospital Assistant DOJ: 16.02.1984 DOJ: 10.10.1983 DOR: 30.06.2014 DOR: 30.06.2014
Sri. K. Pullaiah Sri. P. Krishnappa Dr. Mani Ezhilan. Office Assistant Office Assistant B, Sr. G.D.M.O DOJ: 23.10.1984 DOJ: 09.10.1987 DOJ: 25.04.1988 DOR: 30.06.2014 DOR: 30.06.2014 DOR: 31.07.2014 Smt. Lakshmamma. S Sri. Basavaraju Sri. A. Loganathan Photo Copying Operator Hospital Assistant Accounts Officer DOJ: 30.12.1981 DOJ: 06.05.1983 DOJ: 09.03.1979 DOR: 31.07.2014 DOR: 31.07.2014 DOR: 31.08.2014
Smt. Munirajamma Smt. V.Rukmini Hospital Assistant Hospital Assistant DOJ: 03.11.1980 DOJ: 24.11.1983 DOR: 31.08.2014 DOR: 31.08.2014
Sri. N.Narayana Swamy Sri. S.Sathyanarayanan Dr. Prakashi Rajaram Hospital Assistant Hospital Assistant Addl. Prof. of PSW DOJ: 05.12.1985 DOJ: 25.11.1986 DOJ: 10.07.1981 DOR: 31.08.2014 DOR: 31.08.2014 DOR: 30.09.2014
Sri. R. Nanjappachar Sri. Srinivasa Murthy Medical Records Officer Hospital Assistant DOJ: 20.08.1984 DOJ: 21.02.1983 DOR: 30.09.2014 DOR: 30.09.2014
Smt. Shaheeda Begum Smt. A.G. Jeevamani Victor Kum. K. Lakshmi Kantha UDC Ward Supervisor AAO (Adhoc) DOJ: 06.11.1991 DOJ: 18.06.1986 DOJ: 11.10.1982 DOR: 17.10.2014 (VRS) DOR: 31.10.2014 DOR: 31.10.2014 Smt. P. Murasoli Smt. V. Jaya Sri. Chandrashekar T Manager (Adhoc) Asst. Inst. (Mat Weaving) Hospital Assistant DOJ: 15.05.1986 DOJ: 15.03.1979 DOJ: 27.01.1982 DOR: 31.10.2014 DOR: 31.10.2014 DOR: 31.10.2014
Smt. Lakshmamma Smt. Apranji G Hospital Assistant Hospital Assistant DOJ: 19.02.1984 DOJ: 17.06.1987 DOR: 31.10.2014 DOR: 31.10.2014
Smt. N. Banumathi Sri. J. Sampangiramachar Sri. G. Damodaran AAO (Adhoc) Radiographer UDC DOJ: 30.09.1982 DOJ: 06.09.1997 DOJ: 10.09.1982 DOR: 30.11.2014 DOR: 30.11.2014 DOR: 30.11.2014
Sri. Michael A Sri. Vijaya Kumar S Office Assistant Hospital Assistant DOJ: 19.06.1982 DOJ: 17.02.1984 DOR: 30.11.2014 DOR: 30.11.2014
Dr. V.S. Chandrashekar Dr. J. Suresh Chandra Sri. M. Ramakrishna RMO Sr. Veterinary Officer Manager DOJ: 29.02.1988 DOJ: 07.12.1981 DOJ: 05.04.1983 DOR: 31.12.2014 DOR: 31.12.2014 DOR: 31.12.2014 Smt. R. Sharvani Sri. N.V. Srinivasan Sri. Vijayakumar MP Steno Gr I Steno Gr I Hospital Assistant DOJ: 27.11.1981 DOJ: 20.05.1981 DOJ: 05.11.1983 DOR: 31.12.2014 DOR: 31.12.2014 DOR: 31.12.2014
Sri. Thirupala Sri. B.H. Shivashankar Rao Hospital Assistant AAO (Adhoc) DOJ: 04.07.1986 DOJ: 01.10.1982 DOR: 31.12.2014 DOR: 31.01.2015
Sri. S. Narayana Rao Nazare Manager DOJ: 28.08.1985 DOR: 31.01.2015
Sri. C. Kumar Smt. H. Radhamma Manager Ward Supervisor DOJ: 26.08.1985 DOJ: 25.11.1980 DOR: 31.01.2015 DOR: 31.01.2015
Sri. A.S. Elias Sri. M.V Padmanna Sri. Muniyappa K Sri. Somashekara Rao APRO Driver Grade - I Hospital Assistant Bombore.S DOJ: 11.09.1985 DOJ: 23.01.1984 DOJ: 15.03.1979 Instructor (Bakery) DOR: 31.01.2015 DOR: 31.01.2015 DOR: 31.01.2015 DOJ: 23.05.1979 DOR: 31.03.2015 Smt. Rani M Sri. Narasingha Rao Smt. Sayamma Hospital Assistant Office Assistant Hospital Assistant DOJ: 05.12.1985 DOJ: 15.03.1979 DOJ: 15.07.1981 DOR: 31.01.2015 DOR: 28.02.2015 DOR: 28.02.2015
Sri. Prabhu S, Dr. Adinath Basarikodi Hospital Assistant Sr. G.D.M.O DOJ: 16.01.1985 DOJ: 04.04.1988 DOR: 28.02.2015 DOR: 31.03.2015
Smt. P. Vijayalakshmi Sr. Private Secretary DOJ: 28.03.1979 DOR: 31.03.2015
Sri. G. Kumar Dr. S .Sulekha Personal Secretary Senior Technician DOJ: 02.07.1980 DOJ: 01.06.1983 DOR: 31.03.2015 DOR: 31.03.2015
Sri. Somashekara Rao Smt. Yellamma Smt. Muddamma T Bombore.S Office Assistant Office Assistant Instructor (Bakery) DOJ: 29.10.1980 DOJ: 17.12.1981 DOJ: 23.05.1979 DOR: 31.03.2015 DOR: 31.03.2015 DOR: 31.03.2015 Research Collaborations
National
International
Lifting The Burden in Official Relation with the World Health Organization The Global Campaign against Headache
36 | National Institute of Mental Health and Neuro Sciences Awards and Honours
Biophysics Dr. Shoba Srinath, Professor, (i) Awarded a certificate of appreciation by Autism Society of India for outstanding contribution and commitment to improving the lives of people with autism, Bangalore, Dr. Vijay K Kalia, Professor, Member, International Scientific 2 April 2014 (ii) Member of (a) Advisory Body, Jyothy Kendriya Committee, International Conference on Radiation Biology 2014 - Vidyalaya School under the Jyothy Charitable Trust (b) Governing Frontiers in Radiobiology: Immunomodulation, Countermeasures Council, Dr. SR Chandrashekar Institute of Speech and Hearing, and Therapeutics, Institute of Nuclear Medicine and Allied Sciences, Bangalore (c) Board of Studies, Karnataka Parents Association of Delhi, 11-13 November 2014 Mentally Retarded Citizens, Bangalore.
Dr. Shekhar Seshadri, Professor, (i) Member (a) UGC Committee Biostatistics against ragging (b) Advisory Board, Emotional Safety of Schools, Teachers Foundation (c) Management Committee, Richmond Prof. K Thennarasu, Professor, (i) Awarded FSMS award from Indian Fellowship PG College (d) Governing Council Richmond Fellowship Society for Medical Statistics, 2014 (ii) Technical Consultant to Bangalore Branch (e) Adoption Recommendation Committee, Health Department/NRHM, Govt. of Kerala, School Mental Health Department of Women and Child Development, Govt. of Karnataka Survey 2014-15 in the state of Kerala. (f ) Board of Directors, Christel House Learning Centre, Bangalore (g) Advisory Board, Cambridge School, HSR Layout, Bangalore Dr. DK Subbakrishna, Professor, (i) President, Indian Society for (h) Advisory Board, RAHI, Delhi (ii) Secretary General, Richmond nd Medical Statistics (ii) delivered presidential address, 32 Annual Fellowship, National Board (iii) Chairperson, House Committee National Conference of Indian Society for Medical Statistics and Admission Committee, Asha House Richmond Fellowship, (ISMSCON-2014), University of Jammu, Jammu, 12 September Bangalore. 2014. Dr. K John Vijay Sagar, Associate Professor, awarded NIH funded Dr. P Marimuthu, Additional Professor, (i) Visiting Consultant, Indo-USA Fogarty grant for Postdoctoral fellowship in University of Department of Family Medicine and Public Health, School of Florida, Gainesville, USA, October-November 2014. Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman, 21 September 2014 – 24 January 2015. Dr. Sowmya Bhaskaran, Sr. Resident, received ICMR travel grant to attend ICAPP 2014, Paris, France, December 2014. Dr. Mariamma Philip, Sr. Scientific Officer, External Mentor – Maternal Health Young Professionals (India), Mentoring Program (MHYP), St. John’s Medical Research Institute. Clinical Psychology
Dr. B Binukumar, Assistant Professor, chaired a session in Public Dr. Mahendra P Sharma, Professor and Head, (i) Member (a) Expert Health Evidence South Asia (PHESA) Colloquium 2015, Manipal Committee, Rehabilitation Council of India (RCI) (b) Special University, Manipal, 5-7 February 2015. Board of Studies in Clinical Psychology and Education Technology Programme, Pondicherry University (ii) Honorary President, Karnataka Association of Clinical Psychologists (iii) Chief guest Child and Adolescent Psychiatry and delivered keynote address, State-level Symposium on Life Skills Counselling, National Degree College, Jayanagar, Bangalore, 17 Dr. Satish Girimaji, Professor and Head, (i) Resource person, (a) September 2014 Sangath, Goa (b) White Swan Foundation, Bangalore (c) CDAC, Hyderabad and Cochin (ii) Member, Core Committee, National Dr. Anisha Shah, Professor, (i) Member (a) International Family Mental Health Survey of India. Therapy Association, Society for Exploration of Psychotherapy
National Institute of Mental Health and Neuro Sciences 37| Annual Report 2014-15
Integration, American Psychological Association-International Dr. Poornima Bhola, Associate Professor, (i) Editorial Committee Affiliate, American Psychological Association (Divisions of Member, The Journal of Psychosocial Rehabilitation and Mental Theoretical and Philosophical Psychology, Humanistic Psychology, Health (ii) Coordinator, All-India CRN Study Group of the International Psychology, and Psychology for Women) (b) National International Society for Psychotherapy Research Collaborative Board, Richmond Fellowship Society of India. Research Network, USA (iii) Honorary Member, Ethics Sub- Committee, Indian Association of Clinical Psychologists. Dr. Ahalya Raguram, Professor, (i) Fellow of the Indian Association of Clinical Psychologists and Indian Association of Social Psychiatry Dr. Thomas Kishore, Associate Professor, (i) Member (a) National (ii) Member (a) Editorial Board Member, Andhra Pradesh Journal of Consultation Forum on Rehabilitation Research, Rehabilitation Psychological Medicine. Council of India, New Delhi, December 2014 (b) International Advisory Board, The Journal of Intellectual Disabilities, 2015 (c) Dr. Uma Hirisave, Professor, (i) Guest editor, International Journal Academic Council, National Institute for the Visually Handicapped, –Psychological Studies (ii) Member (a) RCI, BOS of NIMH, Dehradun. Secunderabad, (b) BOS, Dept. of Psychology, Kuvempu University, Shimoga (c) BOS, Dept. of Psychology, JN College, Bangalore (iii) Dr. Roopesh BN, Associate Professor, (i) Treasurer, Indian Honorary Consultant-IMRC ( JHMRC) (iv) Expert member (a) Association of Clinical Psychologists (ii) Executive Secretary, Research Advisory Board, Samatvam Science and Research Centre, Cognitive Neuroscience Society of India (iii) Executive Member, Bangalore. Neuropsychological Society of India.
Dr. LN Suman, Professor, (i) Coordinator for developing and implementing a training program for CBI Investigating Officers Epidemiology (IOs) in Scientific Interviewing Methods (ii) Honorary Consultant, ‘Abalashrama’, a home for destitute women (iii) Member (a) Dr. Gururaj G, Professor and Head, (i) Invited Member (a) Board Editorial Board, Women’s Health-Open Journal (b) Editorial Board, of Directors, Lifting the Burden – the Global Campaign against International Journal of Biosciences and Technology. Headache, UK (b) Editorial Advisory Board, Indian Journal of Community and Family Medicine, All India Institute of Medical Dr. Jamuna Rajeswaran, Additional Professor, (i) Adjunct Faculty, Sciences—Bhubaneswar, in collaboration with the Ministry of National Institute of Advanced Studies, IISc, Bangalore (ii) Member Health and Family Welfare, Government of India (c) American (a) ICMR Task Group – vascular cognitive impairment (b) Editorial Association of Physicians of India Traumatic Brain Injury Advisory Board, International Journal of Psychosocial Research. Council, December 2014 (d) Technical Committee, Working Group on Emergency Care in India, Ministry of Health and Family Welfare, Dr. Paulomi M. Sudhir, Additional Professor, (i) Member, BOS, Government of India, February 2015. LGBIMH Tezpur, Assam (ii) Member, Data Monitoring and Safety Committee (DMSC) PREMIUM randomized controlled trials of lay Dr. Pradeep BS, Associate Professor, Member, Editorial Board, counsellor delivered psychological treatments for depressive disorders Public Health Journal, Rajiv Gandhi University of Health Sciences and harmful drinking in primary care. (RGUHS), Karnataka.
Dr. Keshav Kumar, Additional Professor, (i) Member (a) BOS, Dept. of Psychology, Christ University (b) BOS, University of Mysore (c) panel on “Translational Neuroscience in the Altered States of Human Genetics Consciousness – Linking neuroimaging of brain injury and anesthesia for improved diagnosis and prognosis. Conversation, Collaboration Dr. R Gope, Professor and Head, (i) Co-Chairperson, Expert Group and Innovation, University of Cambridge and NIMHANS. on Genetic Research nominated by the Director of Indian Council of Medical Research, National Institute for Research in Environmental Dr. Seema Mehrotra, Additional Professor, (i) received Special Health (NIREH) (ii) Member, BOS in Allied Health Sciences, Sri Achievement Award for contribution to public service mission as a Devaraj Urs Academy of Higher Education and Research, Tamaka, faculty by Faculty Branding Award 2014, by EET-CRS, Education Kolar. Expo TV-Companies Rating System (ii) External Member (as Social Scientist), Institute Ethics Committee, Oxford College of Dr. Chetan GK, Additional Professor, chaired a session at the Physiotherapy. International Symposium on Translational Neuroscience and 32nd
38 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Annual Conference of the Indian Academy of Neurosciences, of Health Sciences, Bengaluru (b) Board of Studies, Dayananda NIMHANS, Bangalore, 1-3 November 2014. Sagar University, Bengaluru (c) Doctoral Committee, Puducherry University, Puducherry (d) Bioethics Committee, Institute of Dr. Manojit Debnath, Assistant Professor, (i) Editorial Board Bioinformatics, Bengaluru. Member (a) Journal of Genetics and Genome Research, ClinMed International Library, Newark, USA (b) Journal of Immunology Dr. Sarada Subramanian, Additional Professor, (i) Member (a) and Vaccine Technology, Open Science Publications, Hyderabad Executive Committee, Society for Neurochemists of India (SNCI) (ii) Grant Reviewer of The Netherlands Organisation for Health (b) Doctoral Committee, VIT University, Vellore. Research and Development (ZonMw) (iii) Chaired a session titled Neurobiology of Schizophrenia: Current Approaches, International Dr. Srinivas Bharath MM, Additional Professor, (i) Member (a) Symposium on Translational Neuroscience, 32nd Annual Conference Institutional Biosafety committee (IBSC), Kemwell Pharma, of the Indian Academy of Neurosciences, NIMHANS, Bangalore, Nelamangala, Bangalore (b) Board of Studies, Dept. of Biochemistry, 1-3 November 2014. University of Mysore (c) Ethics Committee, Rangadorai Memorial Hospital, Bangalore.
Mental Health Education Dr. Nandakumar DN, Additional Professor, (i) received ISNO Award 2015 for the ‘Best researcher in Basic/Translational research in Neuro-oncology’, 7th Annual Conference of the Indian Society Dr. Jayashree Ramakrishna, Professor and Head, Chairperson, Ethics of Neuro-Oncology (ISNO), Kochi, Kerala, 26-29 March 2015. Committee, Foundation of Health Systems Research. (ii) Young investigator colloquium speaker, Asian-Pacific Society of Neurochemistry (APSN2014) Kaohsiung, Taiwan, 23-26 August 2014 (iii) received (a) international travel grant from DBT-CTEP Neuroanaesthesia Management Cell to attend 12th Meeting of Asian-Pacific Society of Neurochemistry (APSN) 2014 Kaohsiung, Taiwan, 23-26 August Dr. Sriganesh, Associate Professor, (i) received WFSA-Baxter 2014 (b) Science and Engineering Research Board international scholarship to attend SAARC AA Congress, Kathmandu, Nepal travel support award to attend 12th Meeting of Asian-Pacific Society 2015 (ii) as Hon. Secretary, received the Best Metro Branch Award of Neurochemistry (APSN2014) Kaohsiung, Taiwan, 23-26 August 2014. 2014 (iv) Member (a) Advisory Committee, National Urban Health Mission (b) Doctoral Committee, Department of Biotechnology, Dr. Ramesh VJ, Professor, (i) Secretary, Indian Society of Dayanand Sagar College of Engineering, Bangalore. Anaesthesiologists, Bangalore City Branch.
Dr. M Radhakrishnan, Additional Professor, Treasurer, Indian Society of Neuroanaesthesiology and Critical Care (ISNACC).
Dr. Dheeraj Masapu, (DM), and Dr. Nitin M, (DM), won first prize in quiz competition, 16thAnnual Conference of Indian Society of Neuroanaesthesiology and Critical Care, Lucknow, India, 30 January-1 February 2015.
Neurochemistry
Dr. Rita Christopher, Professor and Head, (i) awarded the Centre of Excellence in Science, Engineering and Medicine (CESEM), 2014- Dr. Nandakumar DN receiving award from Dr. Vedantam Rajashekhar, President of ISNO 15, by the Vision Group for Science and Technology, Government of Karnataka, for the research proposal entitled ‘Identification of circulating microRNA signature for diagnosis of cerebral small vessel Dr. Harish G, PhD Scholar, (i) received the Asia Pacific Society for disease’ (ii) Expert Member, Newborn Screening Committee, Ministry Neurochemistry- International Society for Neurochemistry Travel of Health and Family Welfare (Child Health Division), Government Award to attend the 12th Asian Society for Neurochemistry Biennial of India (iii) Member (a) PhD Committee, Rajiv Gandhi University Meeting, Taiwan, 23-26 August 2014 (ii) received the Silver Award
National Institute of Mental Health and Neuro Sciences 39| Annual Report 2014-15 for best presentation, 12th Asian Pacific Society for Neurochemistry (APSN) Biennial Meeting, Taiwan, 23-26 August 2014. (iii) received the IBRO Travel Award for oral presentation, 37th Japan Society for Neuroscience, Yokohama, Japan, 11-13 September 2014.
Dr. Gorky Medhi, DM Resident, receiving first prize in Philips MR Neurochallenge 2014.
Dr. Ullas VA, Resident, (i) won first prize, ISPR Lobby Quiz, Vellore,12-13 September 2014 (ii) won 2nd prize, ISPR Online Quiz, Vellore, 12-13 September 2014 (iii) Consolation prize, Poster Presentation, ISNR, New Delhi, 9-12 October 2014.
Awardee Dr. G. Harish with Prof. Andrew J Lawrence, President, Asian Pacific Society for Neurochemistry (APSN) Neurological Rehabilitation
Mr. Prabhakar P, PhD Scholar, secured 2nd prize for poster presentation Dr. Pradnya Dhargave, Physiotherapist, honoured with Dr. MG in 7th Karnataka Science & Technology Academy Conference Mokashi Best Physiotherapist Award by the organizing committee of (KSTA), Government of Karnataka, Oxford College, Bangalore, 5-6 Physiocon-2014, Bangalore, 11 December 2014. February 2015. Dr. T Karthikeyan, Physiotherapist, received ‘Best Academician Ms. Rajini NM, PhD Scholar, received the ICMR International Award’, 3rd International Conference of Physical Therapy, AIIMS, travel grant to attend the AOPMC Conference, Pattaya, Thailand, New Delhi, 18-21 December 2014. 28-30 November 2014.
Neurology Neuro Imaging & Interventional Radiology
Dr. A.K. Gupta, Professor and Head, External Expert for evaluation of DST projects
Mr. Venkataramanappa G, Radiographer, received (i) International Travel Grant from the International Society of Radiographers and Radiological Technologist to attend the 18th International Conference of ISSRT and present a poster on Resting State fMRI in Epilepsy Diagnosis, Helsinki, Finland, 12-15 June 2014 (ii) International Travel Grant from the National University of Singapore to attend South East Asia MRI Workshop and present a poster on Utility Dr. P Satishchandra, Director/Vice-Chancellor, NIMHANS receiving the Functional MRI in Patients with Brain Tumor, Biopolis, Singapore, Karnataka Rajyotsava Award from the Hon’ble Chief Minister of Karnataka Shri. Siddaramaiah 17-18 January 2015.
Dr. Gorky Medhi, DM Resident, won first prize in Philips MR Dr. P Satishchandra, Professor, Director/Vice-Chancellor, (i) Neurochallenge 2014. conferred the prestigious Karnataka Rajyotsava Award—the second
40 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 highest civilian honour of the Karnataka state—by the Government of Mysore (d) Institute Body, Postgraduate Institute of Medical Karnataka for the year 2014 for his contribution to the field of medicine Education and Research, Chandigarh (e) Advisory Group on Scaling (ii) received Professor D.K. Bachhawat Life Time Achievement Up Mental Health, supported by World Health Organisation and Award by the Indian Academy of Neurosciences and delivered a World Bank (vi) Expert Member, Advisory Panel, National Academy lecture on “Bridge over Troubled Water”, International Symposium of Medical Sciences, New Delhi (vii) Co-Chairman, Screening on Translational Neurosciences & XXXII Annual Conference,1 Committee on Initiative of Neuroclinical Research Education November 2014 (iii) Chairman (a) Zonal Coordination Committee, (INCRE), Department of Biotechnology, Government of India, Organ Transplantation, Government of Karnataka (b) Academic New Delhi (viii) Founder Member, Brain Research Centre, Indian Committee, AIIMS, Bhubaneshwar (iv) Member (a) Board of Institute of Science, Bangalore. Management, MGM Institute of Health Sciences, Navi Mumbai (b) Working Group on Equivalence, Medical Council of India, Delhi (c) Dr. SR Chandra, Professor, (i) Textbook Dedication to Prof. SR Finance Committee, Jayadeva Institute of Cardiology, Bangalore (d) Chandra along with Prof. CD Shahdevan, Roga Vijnana and Vikriti Scientific Advisory Group (SAG), Division of Non Communicable Vijnana, Volume 2 Chowkhamba Sanskrit Series Office, Varanasi Disease, ICMR, New Delhi (e) Governing Council, Sri Venkateshwara (ii) Received Meritorious Service Award from Patients Association, Institute of Medical Sciences, Tirupathi (f ) Task Force, Indian Council Alappuzha, Kerala for service rendered to that district. for Medical Research ( ICMR) (g) Advisory Board for the National Dementia Summit, New Delhi 2010 (h) Standing Committee on Dr. Subasree R, Assistant Professor, received Young Investigators/ Science and Technology and related matters, constituted by the Scientist Bursary 1150 Euros by World Congress of Neurology for Ministry of Home Affairs, Government of India from November attending the World Congress of Neurology, Austria, Vienna, 21-26 2011 for three years (i) Advisory Committee, Gulbenkian Global September 2013 Mental Health Platform, Lisboa, Portugal (j) Scientific Advisory Committee, National Centre for Disease Informatics and Research, National Cancer Registry Programme, Department of Health Neuromicrobiology Research, Ministry of Health and Family Welfare, Government of India (k) Research Advisory Council, AIIMS, New Delhi (l) National Dr. R Ravikumar, Professor and Head, (i) DBT nominated Advisory Board, JAPI (m) Executive Council, Institute of Human External Expert, Institutional Bio-safety Committee, Institute of Behaviour and Allied Sciences, New Delhi (n) Indian Council Bio-informatics, Bangalore (ii) Member, Advisory Committee for for Cultural Relations (ICCR), New Delhi (o) Academic Council, establishing high-tech laboratories in BBMP Referral Hospitals, Swami Vivekananda Yoga Anusandhana Samasthana, Bangalore Bangalore, 28 June 2014. (p) Advisory Committee, Bhopal Memorial Hospital and Research Centre, Bhopal (q) National Advisory Group, Ministry of Health and Dr. Shripad A Patil, Professor, (i) Vice President, Indian Immunology Family Welfare, Government of India, New Delhi (r) MGM Journal Society, 2014 (ii) Felicitated with “Bharat Vidya Shiromani Award” of Medical Sciences, MGM Institute of Health Sciences, Navi by International Institute of Education and Management, 2015 Mumbai (s) Genetics Commission, International League Against Epilepsy, (ILAE) USA (t) Advisory Committee, Bhopal Memorial Dr. Nagarathna S, Additional Professor, Local Executive Member and Hospital and Research Centre, Bhopal (u) National Advisory Group, Chairperson for the session: Neuroinfection and Neurodegeneration, Ministry of Health and Family Welfare, Government of India, IAN Conference, Bangalore 1-3 November 2014. New Delhi (v) Special Expert Committee, Department of Health Research, Delhi (w) Scientific Advisory Committee - Partnership Dr. Veenakumari, Additional Professor, Local Executive Member, Programme established by DBT, New Delhi for Advance Research International Symposium on Translational Neuroscience and IAN in Biological Science and Engineering, Department of Biological Conference, Bangalore, 1-3 November 2014. Sciences (DBS), IISc, Bangalore (x) National Think Tank (India Backbone Implementation Network – IBIN)- Planning Commission, Government of India (Secretariat, Bangalore Baptist Hospital) (y) Standing Finance Committee, All India Institute of Medical Neuropathology Sciences, Bhubaneswar (v) Member (a) Editorial Board, International Journal of Epilepsy (IJEP) (b) The High Level Advisory Committee Dr. SK Shankar, Emeritus Professor, Prof. Mehdi Hasan Memorial on National Policy on Universal Electronic Accessibility, Government Lecture on ‘Understanding Neuroscience through the Looking Glass of India, Ministry of Communications and Information Technology, of Human Anatomical Pathology’, 32nd Annual Conference of Indian New Delhi, March 2014 (c) Governing Body, JSS Medical College, Academy of Neurosciences, NIMHANS, 3 November 2014.
National Institute of Mental Health and Neuro Sciences 41| Annual Report 2014-15
Dr. Vani Santosh, Professor and Head, (i) External Expert, Board of Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvanathapuram (2010-to date) (ii) Expert Member, ‘Vision Group’, Department of Science and Technology, Government of Karnataka (from 2013) (iii) Member, Executive Committee, Neurological Society of India (NSI).
Dr. Sundar Periyavan, Professor, (i) Executive Member, KSBTC (ii) NACO Training Centre Assessment of B.J Medical College, Ahmedabad, Guajrat and Rakthadaan Kendra, Valsad, Gujarat, October 2014.
Dr. Arun HS, Resident, received (i) Travel Bursary by International th Society of Neuropathology to attend 18 International Congress of Dr. BS Shankaranarayana Rao, Professor being awarded with KT Shetty Neuropathology, Rio, Brazil, September 2014 (ii) ISNO - President’s Memorial Oration for the outstanding contributions to neurosciences from Award for the Best Student (Clinical), 6th Indian Society of Neuro the Indian Academy of Neurosciences (IAN) Oncology Conference, Lucknow, April 2014. Dr. BS Shankaranarayana Rao, Professor, (i) awarded (a) KT Shetty Memorial Oration for the outstanding contributions to neurosciences from the Indian Academy of Neurosciences Neurophysiology (IAN), 2 November 2014 (ii) received (a) Krantiveera Sangolli Rayanna Award in recognition of outstanding contributions and Dr. TR Raju, Professor and Head, attended (a) PRC Meetings, excellence in the field of Medical Sciences by Karnataka State ICMR, New Delhi: 16 April 18-19 June 2014 (b) the IEC Human Mandahaasa Organization, Bangalore, 9 November 2014 (b) Sri Studies Meeting of NCBS, TIFR, GKVK Campus, Bangalore, 5 June Jayachamarajendra Wadeyar Award for outstanding contributions 2014, 13 November 2014, 12 February 2015 (c) Victoria (Australia) and excellence in the field of Neuromedicine, 18 April 2014 (iii) India Scientific Interaction Meet, West End Hotel, Bangalore, 21 Member (a) Advisory Committee, Ministry of Communications July 2014 (d) Scientific Advisory Committee Meeting, NISCAIR, and Information Technology, Government of India, New Hyderabad, Andhra Pradesh, 14 August 2014. Delhi,2014-till date(b) Institutional Ethics Committee, Institute of Trans-disciplinary Health Sciences and Technology, Bangalore, Dr. Bindu M Kutty, Professor, (i) Adjunct faculty in consciousness 2014-till date (c) Board of Studies, Dr. Ambedkar Institute of studies, National Institute of Advanced Studies (NIAS), Bangalore, Technology, Bangalore, 2013-till date (d) Planning Committee, 2015 (ii) Member (a) Program Advisory Committee, Health DST-SERB Neuroscience Schools, Department of Science and Sciences, SERB, DST, New Delhi (b) Translational Neuroscience Technology, Government of India, 2012-till date (e) Institutional Committee, ICMR (c) Indian Sleep Medicine Certification by Ethics Committee, Institute of Ayurveda and Integrative Medicine AASM (American Association of Sleep Medicine) (d) Institute (I-AIM), Bangalore, 2011-2014 (f )The Indian National Node for Ethics Committee, NIMHANS (e) Executive Committee, Neuro Informatics (INNNI), India (iv) Secretary, Indian Academy Cognitive Neuroscience Society of India (CNSI) (f ) Executive of Neurosciences (IAN)- Bangalore Branch, 2012-till date(iv) Committee, International J. Clinical and Experimental Physiology Treasurer, Society for Neuroscience (SFN) - Bangalore branch, 2008- (g) Journal of Biological Sciences (iii) Vice President, Association of till date (vi) Co-organizer, Member, National Advisory Committee, Physiologists, India (iv) General Secretary, Indian Society for Sleep National Conference on Stress and Health: Frontiers of Research Research (ISSR) (v) Teaching Faculty, National Sleep Medicine in Stress Related Diseases and Management, Maharani’s Science Course (NSMC). College for Women, Bangalore, 12-13 February 2015 (vii) Panelist and Resource Person, The First IBRO-APRC Global Advocacy Dr. TN Sathyaprabha, Additional Professor, (i) Member (a) Workshop, IBRO-TIFR Neuroscience Symposium, Tata Institute Advisory Committee and Ethics Committee, National Institute of Fundamental Research, Mumbai, 3-4 February 2015 (viii) of Unani Medicine, AYUSH, Bangalore (2014-till date) (b) Chairperson, Professor SK Kulkarni Young Scientists Symposium, Institutional Ethics Committee, Jindal Institute of Naturopathy, 1st IBRO/APRC Chandigarh Neuroscience School on Basic and Bangalore (ii) Secretary, Society for Neuroscience (SFN)-Bangalore Research Concepts of Depression and Cognitive Dysfunction, Branch (2008-till date) (iv) Member, National Advisory Committee, University Institute of Pharmaceutical Sciences, Punjab University, and Chairperson of a session, APPICON 2014, Cuttack, Orissa, Chandigarh, 2-8 November 2014 (ix) Expert Member, Peer Review November 2014. Meeting of DIPAS 7th Five Year Plan on ‘Facilitating performance
42 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 in military environment: Systems biology approach’, Defence Neurosurgery Institute of Physiology and Allied Sciences (DIPAS), Ministry of Defence, Govt. of India, Delhi (x) Advisory Board Member, Bioinfo Dr. Indira Devi, Professor and Head, Vice-Chairperson, WFNS Publications, Neuroscience Research Letters (xi) Editorial Advisory Peripheral Nerve Surgery Subcommittee Board Member, Journal of Pharmaceutical and Biological Science (xii) Editorial Board Member (a) Metabolic Brain Disease (b) Dr. Malla Bhaskara Rao, Professor, (i) awarded FRCS by the Journal of Natural Science, Biology and Medicine (c) International Royal College of Surgeons of England, London, UK (ii) Executive Journal of Modern and Alternative Medicine Research (d) Journal Committee Member (a) Neurological Society of India (b) Indian of Krishna Institute of Medical Sciences University (e) Neuroscience Epilepsy Society (c) Indian Epilepsy Association (Bangalore Research Letters (f ) Trends in Biotechnology Research (g) Science Chapter) (ii) Treasurer, Indian Society of Stereotactic and functional Discovery (h) International Journal of Molecular Biology and Neurosurgery (iii) Member, TBI, India Advisory Council. Biochemistry.
Dr. Laxmi T Rao, Associate Professor, (i) External Member, Life Science Research Board (LSRB)-DRDO, New Delhi (ii) Member (a) Advisory Board of Annals of Neuroscience (b) Constitution Amendment Committee (CAC) for Association of Physiologists and Pharmacologists of India (APPI) (iii) Secretary, APPI-Bangalore Chapter (iv) Nominated Member, Advisory Committee, Center with Potential for Excellence in a Particular Area (CPEPA) of University of Calcutta, University Grants Commission (UGC) (v) Executive Member (a) Indian Academy of Neuroscience (IAN) (b) Indian Society for Sleep Research (ISSR) (c) Society for Neuroscience (SFN), Bangalore Chapter.
Dr. Phalguni Anand Alladi, Sr. Scientific Officer, Expert, Neuroscience Prof. Malla Bhaskara Rao receiving the FRCS award from Professor Norman Task Force of the DBT, India. Williams, President of the Royal College of Surgeons of England at London, UK
Ms. Anu Mary Varghese, CSIR-SRF, PhD Scholar, received Tulsabai Somani Educational Trust Award for best paper presentation at Dr. Dhaval P Shukla, Additional Professor, (i) Member, Executive the oral session, 32nd Annual Conference of Indian Academy of Committee of Neurotrauma Society of India, (ii) AAPI India TBI Neuroscience, NIMHANS, 1-3 November 2014. Advisory Council Cervical Spondyloptosis (iii) WFNS Peripheral Nerve Surgery Subcommittee.
Dr. Dhananjaya I Bhat, Additional Professor, (i) awarded Alfred Neurotrauma Award, Neurotrauma Conference, Mussoorie, August 2014 (ii) Member, WFNS Peripheral Nerve Surgery Subcommittee
Dr. Arivazhagan A, Associate Professor, Awarded, 2014 ISNO President’s Award for The Best Clinician Researcher in Basic Neuro Oncology, 6th Annual Conference of the Indian Society of Neuro- oncology, Indian Society of Neuro Oncology, Lucknow, India, 11-13 April 2014.
Dr. Nishant Sadashiva, Resident, conferred Herbert Krause Neurooncology Award, 63rd Annual Conference of the NSI, Ms. Anu Mary Varghese, CSIR-SRF PhD Scholar, receiving Tulsabai Somani Coimbatore, 12-15 December 2014. Educational Trust Award for best paper presentation
Dr. Arun Babu, Resident, conferred NSI Award for the best paper in Mr. Sunil J Tripati, PhD Scholar, awarded CSIR- Senior Research Neurosurgery, 63rd Annual Conference of the NSI, Coimbatore, 12- Fellowship, 2014-2018. 15 December 2014.
National Institute of Mental Health and Neuro Sciences 43| Annual Report 2014-15
Dr. Manish Joseph, Resident, Best Paper Award (non-competitive Nursing category), NEUROPEDICON 2014, Bhubaneswar, Orissa.
Dr. K. Lalitha, Professor and Head, (i) Chief Guest (a) Workshop Dr. Jithender Chaturvedi, Resident, 2nd Best Paper Presentation Award, on Inculcating Quality in Nursing, Maruti College of Nursing, ANTC-2104, AIIMA, New Delhi, 31 October- 1 November 2014. Bengaluru,3 April 2014 (b) Workshop for Nursing Superintendents to update their role in management of tuberculosis, NIMHANS, 21 July Dr. Tushar Borde, Resident, Best Clinical Presentation, 7th NSI 2014 (c) Lamp Lighting Ceremony – 2015, M.S. Ramaiah Institute of Teaching Session, NIMHANS Bangalore, 31 January-1 February 2014. Nursing Education and Research, Bengaluru, 16 March 2015 (ii) First Professor to be honoured with MTIN Endowment Chair–Charotar Dr. Harsh Deora, Resident, First Prize in MCQ exam, 7th NSI University of Science and Technology, Manikaka Topawala Institute Teaching Course, NIMHANS, Bangalore, 31 January 2015-1 of Nursing (formerly known as Charotar Institute of Nursing), February 2015. Gujarat, 6-10 December 2014 (iii) Guest of Honour, 1st National Conference on Issues, challenges and competencies in nursing, Indian Society of Medical Surgical Nurses, India, in collaboration Neurovirology with Global College of Nursing, Bengaluru,12 December 2014 (iv) Board Member, School of Health Sciences, IGNOU, New Delhi Dr. Madhusudana SN, Professor, (i) received (a) Bharat Vidya (v) NAAC Assessor (a) Sri. Ramachandra University, Chennai, 19- Shiromani Award by the International Institute of Education and 21 August 2014 (b) Dr. D.Y. Patil University, Navi Mumbai, 17-20 Management, New Delhi, 22 December 2014 (b) Rashtriya Vidya September 2014 (vi) Master Trainer (a) Six-day training programme Gaurav Gold Medal by Indian Solidarity Council, Government on Teaching Methodologies developed under fhi360 SNEH Project, of India, New Delhi, 22 December 2014 (ii) External Member First Regional Training, New Delhi, 25-27 August 2014 (b) Third (DBT-nominated), Institutional Biosafety Committee of Gangagen Regional Training for the North East and Eastern States, Kolkata, Biotechnologies Ltd., Bangalore. 15-17 October 2014 (c) Six-day Training Programme on Teaching Methodologies for Nursing Tutors of Southern Region, under fhi360- Dr. V Ravi, Professor, (i) Member (a) Institute Body, Standing SNEH Project, NIMHANS, Bengaluru, 22-27 September 2014 (vii) Finance Committee and Standing Selection Committee and Member, fhi360-SNEH, two-day Consultation Meeting on Govt. of Academic Council, AIIMS, Raipur (b) Academic Council of India Continuing Nursing Education (CNE) Programme, Ministry JIPMER, Puducherry, for a period of three years (ii) and as Registrar of Health and Family Welfare, Govt. of India, New Delhi, 28-29 NIMHANS initiated systems related to online entrance examinations October 2014 (viii) 5th Meeting of Committee for the Courses and for PG medical and allied courses, drafted a comprehensive proposal Studies (BOS) under Guwahati University, for MSc Nursing Course, for establishing a Neurosciences Sub Specialty block (124 additional LGB Regional Institute of Mental Health, Assam, 7 November 2014 beds and 3 OTs), implemented the Digital Subtraction Angiography (ix) Governing Body member RVS College of Nursing, Coimbatore, unit, Women’s Dedicated Inpatient facility, Virtual Knowledge 7 March 2015 (x) Member (a) Core Group Meeting, to finalise Network Centre, 3T MRI-PET facility and NIMHANS Heritage curriculum framework for developing module on enhancing teaching Museum. skills of nursing tutors, Share India, Hyderabad (b) UG/PG Board of Studies Meeting, Mother Theresa Post Graduate and Research Dr. Anita Desai, Additional Professor, (i) Appointed as (a) WHO Institute of Health Sciences, Pondicherry (c) PhD Committee, Consultant, WHO-SEARO to review laboratory practices at various IGNOU, New Delhi (d) Working Committee for preparation of levels (health posts, community, district and referral), in Timor KPHS Draft, by Govt. of Karnataka, KHSDRP Health and Family Leste, June 2014 (b) WHO Consultant, WHO-SEARO to provide Welfare Department (e) Governing Council for Nursing, PIMS, laboratory training on RT-PCR procedures, review SOPs, quality Pondicherry (f ) Board of Studies for UG/PG, PIMS, Pondicherry (g) systems and develop bio-safety guidelines for the influenza laboratory, Advisory Board, Governing Body, Institute of Nursing Science Studies Public Health Laboratories, Thimpu, Bhutan, August 2014 (ii) and Research (INSSR), Gwalior, Madhya Pradesh (h) Board of Member, Expert Group on Communicable Diseases to review Studies in Nursing for framing of syllabus for various Nursing Courses fellowship proposals and reports, ICMR, New Delhi (iii) NACO of Sri Balaji Vidyapeeth University, Pondicherry (i)Advisory Board nominated assessor of laboratories for molecular testing under of Governing Body, Institute of Nursing Science Studies & Research Clinton Health Access Initiative, September 2014. (INSSR), Gwalior, Madhya Pradesh (j) Peer Review Committee, TNAI Editorial Advisory Board (EAB) (k) Governing Council, RVS Dr. Reeta Mani, Assistant Professor, (i) Director-Publications, Rabies Educational Trust, Coimbatore (l) Board member of School of Health in Asia (RIA) Foundation (ii) Member, H1N1 Core Committee, Sciences, IGNOU, New Delhi (xi) NAAC Expert Member, Peer Karnataka. Team, (xii) Editorial Board Member (a) Journal of Krishna Institute
44 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 of Medical Sciences University, ISSN 2231-4261, Maharashtra Mrs. Fiona Mariola D’ Mello, Staff Nurse, received NSICU Florence (b) Nursing Journal of India (c) Prism’s Nursing Practice Journal of Nightingale Award instituted by C. Krishnaiah Chetty & Sons Clinical Nursing Education, Training and Career Development Foundation, Bangalore, on the occasion of International Nurses Day, NIMHANS, 12 May 2014. Dr. Ramachandra, Additional Professor, (i) Expert, spot assessment, People’s University, Bhanpur, Bhopal, 4-7 September 2014 (ii) Principal Coordinator, National Consensus Workshop for GFATM staff, Bangalore, 22-23 August, 2014 (iii) Member, Core Group Committee, Core Group of National Consortium for PhD in Nursing, Indian Nursing Council, New Delhi (iv) Member, Board of Studies-Nursing, Sri. Ramachandra University, Chennai.
Dr. Sailaxmi Gandhi, Associate Professor, (i) received the prestigious National Florence Nightingale Award for Nurse Educator from the Hon’ble President of India, Rashtrapathi Bhavan, New Delhi, 12 May 2014 (ii) Chief Guest, Inaugural Function of the National Conference on ‘Global Trends in Evidence Based Nursing Practice – A Key to Mrs. Fiona Mariola D’ Mello, Staff Nurse, receiving NSICU Florence Nightingale Award instituted by C. Krishnaiah Chetty & Sons Foundation, Bangalore Excellence in Health Care’, SRM University, Chennai, 23 July 2014 (iii) Nursing Expert, Experts Workshop on Development of Curricula, Health Promotion for School Youth by Nurses (HePSY-N), JNV Mrs. L. Rathnamma, Staff Nurse, Psychiatric Rehabilitation Services, Schools organised by the United Nations Population Fund (UNFPA) received ‘Vocational Excellence Award’, Rotary Bangalore East, 7 in collaboration with the National Council of Educational Research October 2014. and Training (NCERT) and St. John’s Research Institute, St. John’s Medical College and Research Institute, Bengaluru, 27 November 2014 (v) Associate Editor, RGUHS Journal of Nursing Sciences ollege of ursing (vi) Member (a) PhD Research Advisory Committee (RAC), Sri C N Ramachandra University, Chennai (b) Editorial Board, Journal of Dr. Pratibha Swamy, Associate Professor, (i) Editorial Board Member Psychosocial Rehabilitation and Mental Health (c) Advisory Board, (a) International Journal of Nursing Critical Care, New Delhi (b) Indian Journal of Continuing Nursing Education. International Journal of Emergency and Trauma Nursing, New Delhi (c) International Journal of Oncological Nursing, New Delhi Dr. G Radhakrishnan, Assistant Professor, (i) Awarded Fellowship (Fellow of Indian Society of Psychiatric Nurses), 14th National Dr. S. Valliammal, Lecturer, Editor for the Workshop Manual (a) Conference of Indian Society of Psychiatric Nurses, Ahmedabad, 31 successful mentoring in nursing, 25 October 2014 (b) Evidence based January-2 February 2015. practice, 12 January 2015.
Mrs. R. Rajalakshmi, Clinical Instructor, College of Nursing Dr. Mrs. P. Vijayalakshmi, Clinical Instructor (i) Associate Editor, RN Moorthy Award for scoring highest marks in MSc Psychiatric Indian Journal of Psychiatric Nursing (ii) Member (a) Advisory Nursing, February 2014. Board, Canadian Journal of Nursing Research (b) Editorial Board, International Archives of Nursing and Health Care Journal. Smt. Soya, Staff Nurse, Pavilion 1, received Best Staff Nurse Award for the year 2013-14 on the occasion of International Nurses Day, NIMHANS, 12 May 2014. Psychiatry Smt. Jessima Mani, Staff Nurse, NIIR, received Best Staff Nurse Award for the year 2013-14 on the occasion of International Nurses Dr. Mathew Varghese, Professor and Head, (i) Member (a) Technical Day, NIMHANS, 12 May 2014. Advisory Committee of the Longitudinal Ageing Study in India (LASI), International Institute for Population Studies, Mumbai (b) Smt. Sridevi, Staff Nurse, Casualty, received Best Staff Nurse Award WHO Consultation Group on the Classification of Behavioural and for the year 2013-14 on the occasion of International Nurses Day, Psychological Symptoms in Neurocognitive Disorders for ICD-11, NIMHANS, 12 May 2014. WHO Geneva (c) Karnataka State Mental Health Authority, 2013- 16 (iii) Executive Board Member (a) International Neuropsychiatric
National Institute of Mental Health and Neuro Sciences 45| Annual Report 2014-15
Association (INA) (b) World Association for Psychosocial Rehabilitation Dr. Shivarama Varambally, Additional Professor, received the Dr. (WAPR - International), 2012-15 (iv) President, World Association for Vimla Virmani Award 2014 by National Academy of Medical Psychosocial Rehabilitation (India) Foundation, 2011-15 (v) Chairman, Sciences (India), NAMSCON 2014, for outstanding work in the area National Dementia Strategy of the Alzheimer’s and Related Disorders of rehabilitation of neurologically/mentally afflicted subjects, AIIMS, Society of India (ARDSI) and Vice-President ARDSI, Bangalore. Rishikesh, 19 October 2014.
Dr. Prabha S Chandra, Professor, (i) Elected Secretary, International Dr. Mehta UM, Assistant Professor, Received, Young Investigator Association of Women’s Mental Health (ii) Nominated Member, Travel Award – 2015, 15th International Congress on Schizophrenia Publications Committee of World Psychiatric Association (iii) Research, Colorado Springs, USA. Chairperson, Ethics Committee, Centre for Public Policy, IIM, Bangalore (iv) Member, Advisory Board- White Swan Foundation Dr. Prabhat Kumar Chand, Associate Professor, received Indo US for Mental Health. Public Health Fellowship, Project ECHO, University of New Mexico, Albuquerque, USA. Dr. Pratima Murthy, Professor, (i) International Trainer, human resource development for tobacco cessation programme, WHO SEARO, Thimpu, Bhutan,17-20 November 2014 (ii) Chairperson, Psychiatric Rehabilitation Scientific Committee, Bangalore, IPSOCON 2014(iii) Member (a) Health Core Group, National Human Rights Commission, New Dr. SK Chaturvedi, Professor, (i) Member (a) University Grants Delhi, January 2015 (b) Technical Review Committee on Mental Commission (UGC) Expert Committee (for Deemed University Health Care in India, National Human Rights Commission, New status for Dr. Shakuntala Misra National Rehabilitation University Delhi, March 2015(c) IRB, Karuna Trust (d) ICMR Task Force on Lucknow), July-December 2014 (b) Committee to review Mental Drug Abuse in Punjab, ICMR, New Delhi Health Care Bill 2013 amendments, Ministry of Health and Family Welfare, November 2014. Dr. Srikala Bharath, Professor, Vice Chair of the South Asian Division of the Royal College of Psychiatrists, UK, 2014-2018. Dr. Sivakumar T, Assistant Professor, Coordinator, Compilation of suggestions regarding ‘Right to persons with disabilities bill 2014’ Dr. YC Janardhan Reddy, Professor, Member of the WHO Standing Committee on Social Justice and Empowerment, under the International Advisory Group for revision of ICD-10, Mental and Chairmanship of Shri Ramesh Bais, MP, October 2014. Behavioral Disorders: Working Group on the Classification of Obsessive-Compulsive and Related Disorders.
Dr. Vivek Benegal, Professor, (i) Honorary Professor of Psychology, Psychiatric Social Work Department of Psychological Sciences, University of Liverpool, UK (ii) Member (a) Technical Advisory Group on Alcohol Control, Dr. K Sekar, Professor and Head, (i) Member (a) First Expert Group Government of India(b)National Committee of Experts on Harm under the Chairmanship of DDG (MH-IH) to develop a Mental Reduction, Ministry of Finance, Government of India(c) Screening Health Manual for Social Workers in India, DGHS, New Delhi (c) Committee, National Awards for Outstanding Services in Prevention Doctoral Research Committee, Bangalore University, Bangalore (d) of Alcohol and Drug Abuse. Board of Studies, Rajagiri College of Social Work, Kerala (e) Board of Studies, Central University of Karnataka, Central University of Dr. PT Shivakumar, Additional Professor, (i) Vice President, Kerala, Kasargod, and Sri Padhmavathy Mahila Vishwa Vidhyalaya, Alzheimer’s and Related Disorders Society of India (ARDSI)- Tirupathy (f ) Academic Council, National Institute of Orthopedically Bangalore Chapter (ii) Direct Member, Executive Committee, Indian Handicapped, Kolkata (ii) President, Indian Society of Professional Association for Geriatric Mental Health (IAGMH). Social Work (ISPSW), 2014-2016.
Dr. C Naveen Kumar, Associate Professor, (i) received (a) SS Dr. N. Krishna Reddy, Additional Professor, Vice President, Indian Jayaram Award, Indian Psychiatric Society South Zone Conference, Society of Professional Social Work (ISPSW), 2014-2016 Bangalore, October 2014 (b) Tilak Venkoba Rao Award, Annual National Conference of the Indian Psychiatric Society, Hyderabad, Dr. R Dhanasekara Pandian, Associate Professor (i) chosen for the India, January 2015 (ii) Expert, Consultative Meet to formulate prestigious Dr. Abdul Kalam Life Time Achievement Award for the draft of the Public Health Act, National Law School of India remarkable achievements in the field of teaching and publications University, Bangalore, September 2014. in Sociology-2014 (International Institute for Social and Economic
46 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Reforms, Chanakyapuri, New Delhi) (ii) Member (a) Editorial Clinical Neurosciences Committee, British Journal of Social Work (b) Expert Group under the Chairmanship of DDG (MH-IH) to develop a Mental Health Manual for Social Workers in India, DGHS, New Delhi Dr. Soundarya S, Jr. Resident, (i) Elsevier Student Ambassador 2014- (iii) Honorary Board Member (a) International Alcohol and Drug 15 (ii) Ambassador for Readcube, May 2014. Counselor’s Certification Trust for India (IADCC) (b)Academic Council, Madurai Institute of Social Sciences, Madurai (iii) Honorary Dr. Chetan S Nayak, Sr. Resident, (i) Travel Grant to participate in Treasurer, Indian Society of Professional Social Work (ISPSW) the Wellcome Trust/DBT India Alliance: Science Communication (iv)Visiting Fellow, University Grants Commissions (UGC), Sri (SciComm) 2015workshop, Hyderabad (ii) ILAE educational bursary Padmavathi Mahila Visvavidyalayam, Tirupati. award to participate in the VIREPA online course on Epilepsy and Sleep – Clinical Part II, 2014-2015 (iii) Indian Society of Sleep th Dr. BP Nirmala, Associate Professor, (i) Editorial Board Member, Research (ISSR) bursary award to attend 8 Asian Sleep Research Journal of Psychosocial Rehabilitation and Mental Health (ii) Society Congress ‘ASRS 2014’, Thiruvananthapuram, Kerala. Industry, NGO collaboration SUN IT, HCL, APD, APMRC, Samarthanam (iv) Reviewer/Editor, JNSBM and IJPM journals Dr. Sowmyashree Mayur Kaku, Sr. Resident, (i) (a) Donald J Cohen (v) Invited to NIMH National consultative committee meeting Fellowship Award by the International Association for Child and st for National modular programme for MI and MR (v) Executive Adolescent Psychiatry and Allied Professions (IACAPAP), 21 Committee Member, ISPSW. International Congress of IACAPAP, Durban, South Africa 2014 (b) Beacon Club Scholarship by World Association of Infant Mental Dr. N Janardhana, Associate Professor, (i) Member, Committee of the Health 2014 (c) Travel grant to participate in the Welcome Trust/ Empowerment of Differently Abled and Senior Citizen Department, DBT India Alliance: Science communication workshop (SciComm) Government of Karnataka for (a) scrutinizing applications from Nov 2014 (ii) Editor, Journal of Asian Medical Students Association. NGOs requesting grants for running the residential and day schools for disabled children (b) for revising the rule and enhancing the age of the Dr. Ketan Jhunjhunwala, Sr. Resident, MDS Travel Grant for th children from 18 to 25 in case of children with intellectual disabilities attending the 18 International Congress of Parkinson’s Disease and enrolled in the schools receiving grants from the Government. Movement Disorders, Stockholm, Sweden, June 2014.
Dr. Vranda MN, Assistant Professor, (i) Core Committee Member, Dr. Arun H Shastry, Sr. Resident, received (i) ISNO - President’s Award th Special Unit for Women Affected by Domestic Violence, Department for the best student (Clinical), 6 Indian Society of Neuro Oncology of Women and Child Development, Government of Karnataka, Conference, Lucknow, April 2014 (ii) Travel bursary award by th Bangalore (ii) Recognised by UNDP research survey for the service International Society of Neuropathology to attend 18 International of Awake Clinic for Intimate Partner Violence as best practices in the Congress of Neuropathology, Rio, Brazil, September 2014. prevention of Gender Based Violence. Dr. Rakesh Balachandar, Sr. Resident, (i) Travel Grant from the Alzheimer’s Association International Conference 2014 (AAIC) poster presentation, AAIC Conference, Copenhagen, 13-17 July sychopharmacology P 2014 (ii) International Travel Award from Indian Council of Medical Research, 12th International Conference of Alzheimer’s Disease and Dr. Chittaranjan Andrade, Professor, (i) Guest Editor, Global Medical Parkinson’s Disease, France, 18-22 March 2014 (iii) travel grant Education Research Review, USA, August 2014 (ii) Chairman, for poster presentation, Alzheimer’s Association International Task Force on Psychopharmacology, Indian Psychiatric Society (iii) Conference (AAIC) 2014, Washington, 18-23 July 2014. National Advisory Board Member, Indian Association of Private Psychiatrists. Dr. Vikas Dhiman, Sr. Resident, (i) Bursary Award by the International League against Epilepsy (Commission on European Affairs, CEA) and International Federation of Clinical Neurophysiology to attend Speech Pathology and Audiology Dianalund Summer School on EEG and Epilepsy in Denmark, 13-19 July 2014 (ii) Junior Travel Fellowship ( JTF) by the World Federation Dr. M Jayaram, Sr. Professor, Chairman, Expert Group on Speech of Neurology (WFN) to attend 10th Asian Oceanian Epilepsy and Hearing of the Rehabilitation Council of India. Congress in Singapore, 7-10 August 2014 (iii) Travel Bursary from International League against Epilepsy (ILAE) to attend 10th Asian Dr. N Shivashankar, Professor, Chairman, Seva-in-Action, Bangalore. Oceanian Epilepsy Congress in Singapore, 7-10 August 2014.
National Institute of Mental Health and Neuro Sciences 47| Ravi Hegde Visitors to NIMHANS
1. Dr. Maria Inês Nogueira, Associate Professor, Institute of 10. Dr. Shreyasi Chatterjee, Research Scientist, University of Texas Biomedical Sciences, Universidade de São Paulo, Brazil, visited Medical Branch, Galveston, Texas, USA, visited the Dept. of the Dept. of Neurophysiology and delivered a lecture, ‘Exploring Neurochemistry and delivered a lecture, ‘Regulation of TAU the effects of Neonatal Anoxia in the rat´s Hippocampus’, phosphorylation and toxicity: Insight from a drosophila model 7 May 2014. of neurodegeneration’, 27 June 2014.
2. Prof. Joseph Zohar Sackler, Faculty of Medicine, Tel Aviv 11. Dr. Shekhar Saxena, Director, Mental Health Division, WHO, University, Israel, visited the Dept. of Psychiatry and delivered Geneva, visited the Dept. of Epidemiology and delivered a a lecture, ‘Heterogeneity in OCD’, 12 May 2014. lecture, ‘Issues in Mental Health Programme implementation’, July 2014. 3. Dr. Murlidhar L Hegde, Assistant Member, Houston Methodist Neurological Institute and Hospital, Texas, USA, visited the 12. Dr. Koushik Chakrabarthy, Scientist, University of Bochum, Dept. of Neurochemistry and delivered a lecture, ‘Imbalance in Germany, visited the Dept. of Neurochemistry and delivered a genome damage and repair responses as a common etiological lecture, ‘Deciphering the neuronal code towards cell replacement basis for neurodegenerative diseases’, 12 May 2014. therapy’, 2 July 2014.
4. Ms. Shinjini Chatterjee, Senior Editor, Human Sciences, 13. Dr. Anil Mathew, Professor of Biostatistics and Gen. Secretary, Springer India, visited the Dept. of Psychiatric Rehabilitation, ISMS, visited the Dept. of Biostatistics and spoke on ‘Adjusted 15 May 2014. analysis in clinical research: Confounding and interaction’, 8 July 2014. 5. Shri. CS Kedar, CEO, JSW Foundation, visited NIMHANS and delivered a presentation, ‘Corporate Social Responsibility’, 14. A team from Sakra World Hospital, a joint venture company 17 May 2014. between Kirloskar Group, Toyota Tsusho and Secom Hospitals, visited the Dept. of Psychiatric Rehabilitation, 10 July 2014. 6. Ms. Garimaa Srimal, Clinical Psychologist from Aurangabad, visited the Dept. of Clinical Psychology and delivered a lecture, 15. Ms. Sreeja Sreedhar, Program Director, Sarojini Damodaran ‘Psychotherapy: From training and research to practice’, 30 May Foundation, visited the Dept. of Psychiatric Rehabilitation, 14 2014. July 2014.
7. Dr. Chandrashekar, Professor and Head of Psychiatry, 16. Dr. Ibrahim, Professor of Epidemiology, Kidwai Memorial Bangalore Medical College and Research Institute, Bengaluru, Institute of Oncology, visited the Dept. of Epidemiology visited the Dept. of Epidemiology and delivered a lecture, and delivered a lecture, ‘Cancer Control Programmes in the ‘National Mental Health Programme and District Mental Community’, 18 July 2014. Health Programme in Karnataka’, June 2014. 17. Dr. Sanjeev D Nandedkar, Natus Medical Systems, USA, 8. Dr. Jagannath, Consultant, State Tobacco Cell, Bengaluru, visited the Dept. of Neurology and conducted a workshop on Karnataka, visited the Dept. of Epidemiology and delivered a ENMG, 21 July 2014. lecture on COTPA, June 2014 18. Dr. Srikantan Nagarajan, Professor of Neuroimaging, University 9. Mr. Mohan, District Disability Officer, Govt. of Karnataka, of San Fransisco, USA visited the Dept. of Neurology and visited the Dept. of Epidemiology and delivered a lecture, ‘State delivered a lecture, ‘Multimodality Imaging and MEG in Disability Programmes’, June 2014. Epilepsy, Brain Tumours and Schizophrenia’, 21 July 2014.
National Institute of Mental Health and Neuro Sciences 49| Annual Report 2014-15
19. Prof. Mitchell Weiss, Swiss Tropical for Public Health, Department of Epidemiology, Basel, visited the Dept. of Mental Health Education and delivered a lecture, ‘Cultural Formulation Interview (CFI): Distinctive histories and common ground’, 22 July 2014.
20. Dr. Ramesh, Professor of Epidemiology, Kidwai Memorial Institute of Oncology, visited the Dept. of Epidemiology and delivered a lecture, ‘Cancer Registry in India’, 25 July 2014.
21. Mr. Adam Lane, International Development Officer, Richmond Psychosocial Foundation International, visited the Dept. of Dr. Vinay Chaudhry, Professor of Neurology, Johns Hopkins University, Psychiatric Rehabilitation, 26 July 2014. Baltimore, USA
22. Dr. Neeraj Sunderrajan Naval, Director of Neurosciences Critical Care Unit at Bayview, Assistant Professor of Neurology, 25. Dr. Sriram Chellapan, Assistant Professor, Missouri University Anaesthesiology and Critical Care, Johns Hopkins Hospital, of Science and Technology, USA, visited the Dept. of Clinical USA visited the Department of Neuroanaesthesia and delivered Psychology and delivered a lecture, ‘The impact of internet and a talk on ‘Multimodality monitoring in the Neuro-ICU’, 28 social media data on health management’, 1 August 2014. July 2014. 26. Dr. Bharath Biswal, Professor & Head, Biomedical Engineering, New Jersey Institute of Technology, USA, Chief Principal Investigator of the Human Connectome Project, and team visited the Dept. of Neuroimaging & Interventional Radiology, and delivered a lecture, ‘Human Connectome Project’, 8 August 2014.
Dr. Neeraj Sunderrajan Naval, Director of Neurosciences Critical Care Unit at Bayview, Assistant Professor of Neurology, Anaesthesiology and Critical Care, Johns Hopkins Hospital, USA
23. Dr. Annefrida Kisesa-Mkusa, Regional Adviser (HIV and Dr. Bharath Biswal, Professor & Head, Biomedical Engineering, New Jersey AIDS), UNICEF Regional Office for South Asia (ROSA), Institute of Technology, USA and team Nepal and Dr. Dick Chamla, Health Specialist, UNICEF New York visited the Dept. of Neurovirology, 31 July 2014. 27. Shri. Arun K Panda, Additional Secretary (Health), Ministry of 24. Dr. Vinay Chaudhry, Professor of Neurology, Johns Hopkins Health & Family Welfare, Govt. of India, visited the Dept. of University, Baltimore, USA visited the Department of Psychiatric Rehabilitation, 8 August 2014. Neuroanaesthesia and the Department of Neurology, and delivered a lecture on ‘Spectrum of immune neuropathies— 28. Prof. SK Singh, Dr. AR Risbud, Dr. Anil Mishra from the Evolving concepts in Physiology and Serology’, 1 August National Aids Research Institute (NARI), Pune, visited the 2014. Dept. of Neurovirology, 11 August 2014.
50 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
29. Mr. Anshu Prakash, Joint Secretary (Mental Health), Ministry the Institute, 9 September 2014. of Health and Family Welfare, Government of India visited NIMHANS and reviewed National Mental Health Survey 36. Members of the UK Trade & Investments Commission visited activity (Pilot Survey), 18 August 2014. NIMHANS, 22 September 2014.
30. A team of faculty from Deakin University, Australia led by Prof. 37. Dr. Lakshmi N Yatham, Professor, Mood Disorder Centre, David Mellor visited NIMHANS, 19 August 2014. University of British Columbia, Canada, visited the Dept. of Psychiatry and delivered lectures: (a) ‘Current trends in the management of bipolar disorder’, 23 September 2014 (b) ‘Research collaboration in the area of bipolar disorders’, 5 January 2015.
38. Dr. Mohammad Bashir Ahadi, Project Officer, Kabul Mental Health Hospital, International Medical Corps (IMC), Kabul, Afghanistan, visited the Depts. of Psychiatric Rehabilitation and Nursing, 1 October 2014.
A team of faculty from Deakin University, Australia led by Prof. David Mellor
31. Prof. Dinesh Bhugra, Professor of Mental Health and Cultural Diversity, Institute of Psychiatry (KCL), London, President– Elect, World Psychiatric Association, visited NIMHANS and took part in conducting various academic programmes organised by the Department of Psychiatry, 18-20 August 2014
32. Prof. Marita McCabe, Alfred Deakin Professor, School of Psychology, Deakin University, Melbourne, Australia, visited the Dept. of Clinical Psychology and delivered a lecture, ‘Understanding body image from a cross cultural perspective’, Dr. Mohammad Bashir Ahadi, Project Officer, Kabul Mental Health Hospital, International Medical Corps (IMC), Kabul, Afghanistan and team with the 20 August 2014. faculty of the Department of Nursing
33. Dr. Xavier CorbellaVirós, Professor and Head, Internal Medicine Department and Vice-Dean, Faculty of Medicine, Bellvitge 39. Dr. Aishath Ali Naaz, Clinical Psychologist from Maldives, University Hospital and International University of Catalonia visited the Dept. of Clinical Psychology and delivered a lecture, and University of Barcelona, Spain, visited the Departments of ‘Experiences in the field of Clinical Psychology in India, UK Neuropathology and Neurochemistry and delivered a lecture, and Maldives’, 16 October 2014. ‘Epidemiology of Hospital-Acquired Outbreaks of Infections due to Multi-resistant Bacteria’, 4 September 2014. 40. Dr. Matthew Kurtz, Associate Professor, Psychology Department, Wesleyan University, USA visited the Dept. of 34. Dr. Isidro Ferrer Abizanda, Professor of Pathology, University Psychiatric Rehabilitation, 3 November 2014. of Barcelona, Faculty of Medicine, Department of Pathology and Experimental Therapeutics, Director of the Institute 41. Dr. Brendan Crotty, Pro Vice-Chancellor of the Faculty of of Neuropathology and Brain Bank, Hospital Universitari Health, Deakin University, Australia, visited the Dept. of de Bellvitge, Hospitalet de Llobregat, Barcelona visited the Psychiatric Rehabilitation, 7 November 2014. Departments of Neuropathology of Neurochemistry and delivered a lecture, ‘Neuroinflammation in aging and neurodegenerative 42. A team from the Association for People with Disability (APD) disease: Why current anti-inflammatory therapies do not work visited the Dept. of Psychiatric Rehabilitation, 12 November 2014. in neurodegenerative diseases?’, 4 September 2014. 43. Dr. Fateh Mohammad Sultan and team from Psychiatry 35. A team from Trinity College, Dublin, Ireland visited Hospital, Kabul, Afghanistan, visited NIMHANS Centre for NIMHANS and held meetings regarding collaborations with Well Being (NCWB), 14 November 2014.
National Institute of Mental Health and Neuro Sciences 51| Annual Report 2014-15
44. Members of The Nursing and Midwifery Council, UK, visited 52. A team from the Press Information Bureau, Government NIMHANS College of Nursing, 18 November 2014. of India visited NIMHANS and lauded the services of the Institute and the cleanliness aspect at the hospital, 26 45. A team of Psychiatrists from Herat Mental Health Hospital, November 2014. Afghanistan, led by Dr. Bjarte Sanne, a Norwegian child and adolescent psychiatrist, visited the Dept. of Child and Adolescent Psychiatry, 17-19 November 2014.
46. Dr. Rabea Begum, Scientific Officer, Central Disease Investigation Laboratory, Dhaka; Dr. Begum Jesmin, Upazila Livestock Officer, Dhaka; Dr. Mohammed Abdullah Yusuf, National Institute of Neuroscience and Hospital, Dhaka; Bangladesh, Dr. Rohitha Muthugala, Medical Virologist, Medical Research Institute, Sri Lanka and Dr. Dulmini Kumarasinghe, Consultant Virologist, Sri Lanka visited the Dept. of Neuromicrobiology, 19 November 2014.
47. Dr. Bhupendra O Khatri, Professor of Neurology and Medical Director, Center for Neurological Disorders, Milwaukee, USA, A team from the Press Information Bureau, Government of India visited the Dept. of Neurology and delivered a lecture, ‘Therapeutic plasma exchange in MS & NNMO’, 20 November 2014. 53. Prof. SR Kalpana, Department of Pathology, Sri Jayadeva 48. Dr. Arijit Mukhopadhyaya, Senior Scientist and Assistant Institute of Cardiovascular Sciences & Research visited the Professor, CSIR-Institute of Genomics and Integrative Biology Dept. of Neurochemistry and delivered a talk, ‘Pre-Analytical (IGIB), Academy of Scientific and Innovative Research, New and Analytical Errors’, 28 November 2014. Delhi, visited the Dept. of Neurochemistry and delivered a lecture, ‘Genomic mysteries of the human brain’, 21 November 2014. 54. Dr. Patrick Murray, University of Maryland School of Medicine, visited the Dept. of Neuromicrobiology, 3 December 2014. 49. Dr. Prasanna Raj, Additional Secretary, Medical Council of India, New Delhi, visited the Dept. of Epidemiology and 55. Dr. Sunil Thomas, Research Scientist, University of delivered a lecture, ‘Public health and its impact on society’, 22 Washington, Seattle, WA, USA, visited the Dept. of November 2014. Neurochemistry and delivered a lecture, ‘Cell-Intrinsic role for mitochondrial anti-viral signaling molecule (MAVAS) 50. Dr. Narendranath, Professor and Chief Hospital adaptive immune responses against viral infection’, 15 Administrator, MS Ramaiah Hospital, Bengaluru, visited the December 2014. Dept. of Epidemiology and delivered a lecture, ‘Overview of management and materials management’, 25 November 2014. 56. Dr. Gavin Giovannoni, Professor of Neurology, Barts and The London School of Medicine and Dentistry, visited the Dept. 51. Representatives of McGill University, Canada visited the of Neurology and delivered a lecture, ‘Oral therapies- A new Institute and expressed their desire to sign Memorandum of chapter in personalised medicine in MS’, 15 December 2014. Understanding (MOU) with NIMHANS, 25 November 2014. 57. Dr. BJ Prakash Kumar, Director and State Programme Manager, National Health Mission, Govt. of Karnataka, visited the Dept. of Epidemiology and delivered a lecture, ‘Programme Implementation Plan in NRHM’, 20 December 2014.
58. Dr. Devashish Sengupta, Assistant Professor, Department of Chemistry, Assam University (Central University), visited the Dept. of Neurochemistry and delivered a lecture, ‘Role of Fullerenes in Medicinal Nanotechnology: An Introspection’, 5 January 2015. Representatives of McGill University, Canada
52 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
59. Dr. Kenji Ohata, Dr. Yukio Milki, Dr. Hidetomi Terai, Dr. former president of the World Psychiatric Association (WPA) Takehio Uda, from the University of Osaka City, Japan, visited visited the Dept. of Psychiatry and took part as resource person the Dept. of Psychiatry to take part in NIMHANS- Osaka in ‘Leadership and Professional Skills Workshop for Early City University Joint Scientific Program, 7 January 2015. Career Psychiatrists’, 12-15 January 2015.
60. Dr. Sudhir Kakar, psychoanalyst and writer, visited the Dept. of 65. Prof. Mohan Isaac, Professor of Psychiatry (Population Mental Psychiatry and took part in an interactive session with trainees Health) The University of Western Australia, Perth, visited on ‘Psychotherapy practice’, 8 January 2015. the Dept. of Psychiatry and took part as resource person in ‘Leadership and Professional Skills Workshop for Early Career 61. Prof. Sidney Bloch, Emeritus Professor in Psychiatry, Psychiatrists’, 12-15 January 2015. University of Melbourne, and Honorary Senior Psychiatrist, St. Vincent’s Hospital visited the Dept. of Psychiatry and 66. Dr. SK Deuri, Director and Professor of Psychiatry, conducted a workshop on Elusive Art of Psychiatry, 8-10 LGBRIMH, Tejpur, visited the Dept. of Psychiatry and spoke January 2015. on ‘Mental Health Research in North-eastern States’, 13-16 January 2015. 62. Prof. KS Chalam, Special Rapporteur, NHRC visited NIMHANS, 9-10 January 2015. 67. Dr. Dipesh Bhagabati, Professor and Head, Department of Psychiatry, Guwahati Medical College, visited the Dept. of Psychiatry, and spoke on ‘Psychiatry Services and Research in Northeast India’, 13-16 January 2015.
68. Dr. Linda B Cottler, Associate Dean for Research, Dean’s Professor and Chair, Department of Epidemiology, Director of Indo-US Fogarty Program, University of Florida, visited the Dept. of Psychiatry and spoke on ‘Implementation and Translational Science: Where We Need to Go?’, 13-16 January 2015.
69. Dr. Regina Bussing, Interim Chair and Professor of Psychiatry, Co-Director of Indo-US Fogarty Program, University of Prof. KS Chalam, Special Rapporteur, NHRC Florida (UF), visited the Dept. of Psychiatry, and spoke on ‘Overview of Mental Health Research at UF’,13-16 January 63. A team of psychiatrists from the University of Florida (UF), 2015. Fogarty Foundation, visited the Dept. of Child and Adolescent Psychiatry, 11-16 January 2015. 70. Dr. Michael Perri, Dean, College of Public Health and Health Professions and the Robert G. Frank Endowed Professor of Clinical and Health Psychology, Chair – Training Advisory Group, University of Florida (UF), visited the Dept. of Psychiatry and delivered a talk, ‘From Efficacy to Effectiveness in Randomized Clinical Trials of Lifestyle Interventions’, 13- 16 January 2015.
71. Dr. Catherine Striley, Assistant Professor of Epidemiology, University of Florida (UF), visited the Dept. of Psychiatry and spoke on ‘Fogarty International Centre’s Initiatives for Global Health’, 13-16 January 2015.
A team of psychiatrists from the University of Florida (UF), Fogarty Foundation 72. Dr. Robert Cook, Professor of Epidemiology, University of Florida (UF), visited the Dept. of Psychiatry, and delivered a 64. Prof. Norman Sartorius, former Director of the Department lecture, ‘Marijuana Use among HIV Infected and Treatment of Mental Health, World Health Organization (WHO) and Outcomes’, 13-16 January 2015.
National Institute of Mental Health and Neuro Sciences 53| Annual Report 2014-15
73. Dr. Rajiv Tandon, Professor of Psychiatry, University of Florida 82. Dr. Abdul Kadir Bin Abu Bakar, Director, Hospital Permai, (UF), visited the Dept. of Psychiatry and spoke on ‘A Critique Tampoi Johor Bahru, Malaysia, visited the Dept. of Psychiatric on the DSM 5 and Identifying Frontier Areas of Schizophrenia Social Work and spoke on ‘Transforming the Mental Hospital: Research’, 13-16 January 2015. Experiences in Hospital Permai’, 10 February 2015.
74. Dr. Ted Abel, Brush Family Professor of Biology and 83. Dr. Pushpa Narayanaswami, Assistant Professor of Neurology, Director - Biological Basis of Behavior Program, University Beth Israel Deaconess Medical Center (Harvard Medical of Pennsylvania, Philadelphia, USA, visited the Dept. of School), Boston, USA, visited the Dept. of Neurology and Neurophysiology and delivered a lecture, ‘Role of sleep in delivered a lecture on ‘Evaluating randomized controlled trials: memory consolidation’, 16 January 2015. Methodological aspects’, 11 February 2015.
75. Dr. Mick Mulders, Scientist, Laboratory Networks Coordinator, 84. Prof. Eric Lander, President, Board Institute, Harvard and WHO, Geneva, visited the Dept. of Neurovirology, 16 January Principal Scientist, Human Genome Project, Co-Chair, Council 2015. of Advisors for Science and Technology to US President Barack Obama, visited the Dept. of Psychiatry and delivered a lecture, 76. Dr. Krishna Vaddiparti, Assistant Professor, Department of ‘Genetics and Genomics’, 27 February 2015. Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, USA, Assistant Professor, College of Public Health and Health Professions, College of Medicine, University of Florida, visited NIMHANS Centre for Well Being and the Dept. of Psychiatric Social Work and spoke on ‘Indo-US training in non-communicable diseases’, 17 January 2015.
77. Dr. Aarti Taksal, Assistant Professor, TISS, Mumbai, visited the Dept. of Clinical Psychology and delivered a lecture, ‘Integrated psychological interventions in schizophrenia’, 23 January 2015.
78. Dr. K Ramakrishnan, Research Fellow, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, Maryland, USA, visited the Dept. of Neurochemistry and delivered a lecture, ‘Building Prof. Eric Lander’s visit to the Dept. of Psychiatry, NIMHANS neurons for its functions: Dissecting the cellular signaling mechanisms regulating neural patterning’, 23 January 2015. 85. Dr. Martien Snellen, Perinatal Psychiatrist and Dr. Geoff 79. Dr. Majaz Moonis, Director of Stroke Services and Stroke Thompson, Psychiatrist, from Australia, visited the Dept. Prevention Program, University of Massachusetts, USA, visited of Psychiatry, co-chaired Perinatal Case Conference and the Dept. of Neurology and delivered lectures: (i) ‘High dose presented an online session on ‘Obtaining informed consent statins in hyperacute ischemic stroke’, 5 February 2015. (ii) during prescribing psychotropic during pregnancy’, 9-10 ‘Acute stroke management’, 19 March 2015. March 2015.
80. Dr. Uppala Radhakrishna, Beaumont University, Michigan, 86. Prof. David Menon, Head of Division of Anaesthesia, Dr. Srivas USA, visited the Dept. of Human Genetics and delivered a Chennu, Senior Research Associate, Clinical Neurosciences, lecture, Scientific Interactions, 10 February 2015. and team from the University of Cambridge, UK visited the Departments of Neuroimaging & Interventional Radiology 81. Dr. Zebulon Taintor, Adjunct Professor, Department of and Neuroanaesthesia, and delivered a lecture, ‘High-density Psychiatry, New York University School of Medicine, visited Functional Electroencephalography: Methods, Pitfalls and the Dept. of Psychiatric Rehabilitation, 10 February 2015. Inference’, 12 March 2015.
54 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
87. A team of Psychiatrists from Maastricht University, Netherlands, visited the Dept. of Child and Adolescent Psychiatry, 12-14 March 2015.
88. Mr. Sathayanarayana, Principal, and V Jayanthi, Assistant Professor, KIDWAI College of Nursing, Bengaluru visited NIMHANS College of Nursing and delivered lectures, ‘Stoma care’ and ‘Issues in chemotherapy’ respectively, 28 March 2015.
89. Dr. Lokesh V, Professor, Dept. of Radiation Oncology, KIDWAI Memorial Institute of Oncology, visited the NIMHANS College of Nursing and delivered a lecture, ‘Issues in oncology Prof. David Menon, Head of Division of Anaesthesia and team from the treatment and diagnostic measures’, 28 March 2015. University of Cambridge, UK
Art therapeutic activity in Psychiatric Rehabilitation Services, NIMHANS, Bengaluru (Artwork by Praveen Arora)
National Institute of Mental Health and Neuro Sciences 55| Ravi Hegde Patient Care Activities
Registrations 25000
20000
15000
10000 Screening 5000 120000 0 09-10 10-11 11-12 12-1313-14 14-15 100000
PSYCHIATRY CHILD PSYCHIATRY 80000 NEUROLOGY NEUROSURGERY 60000
40000
20000
0 09-10 10-11 11-12 12-13 13-14 14-15
Emergencies (Casualty) 25000
20000
15000
10000 Admissions 5000 7000 0 6000 09-10 10-11 11-12 12-13 13-14 14-15 5000 PSYCHIATRY CHILD PSYCHIATRY 4000 NEUROLOGY NEUROSURGERY 3000 2000 1000 0 09-10 10-11 11-12 12-13 13-14 14-15
PSYCHIATRY CHILD PSYCHIATRY NEUROLOGY NEUROSURGERY
National Institute of Mental Health and Neuro Sciences 57| Annual Report 2014-15
Discharges 6000 5000 4000 3000 2000 1000 Follow-ups 0 09-10 10-11 11-12 12-13 13-14 14-15 140000 120000 PSYCHIATRY CHILD PSYCHIATRY 100000 NEUROLOGY NEUROSURGERY 80000 60000 40000 20000 0 09-10 10-11 11-12 12-13 13-14 14-15
PSYCHIATRY CHILD PSYCHIATRY NEUROLOGY NEUROSURGERY Deaths 600 500 400 300 200 100 Extension Services 0 15000 09-10 10-11 11-12 12-13 13-14 14-15 PSYCHIATRY CHILD PSYCHIATRY 10000 NEUROLOGY NEUROSURGERY
5000
0 09-10 10-11 11-12 12-13 13-14 14-15 GUNJUR GOWRIBIDANUR MADDUR KANAKAPURA MADHUGIRI SAKALAWARA TURUVEKERE
58 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
I. Mental Health Services Perinatal Psychiatry Clinic: New registrations 109 104 Follow-ups 496 672 Mother-Baby Unit inpatient admissions 69 74 sychiatry P 674 850 A. Clinical Services Advance Centre for Yoga New referrals - 1270 Sessions 2128 No. of patients/ 3398 Facilities provided cases Priority Ward (ASIST and SAFER)* 2013-14 2014-15 Admission 254 General Adult Psychiatry Services Transfer-in Nil 174 Screening 106227 113135 Discharge 179 Registrations 12915 14016 Transfer-out 252 Emergency Services 2330 7445 859 Follow-ups 95715 102439 Admissions* 5850 5565 Transcranial Direct Current Stimulation - 57 Discharges 5402 4871 (tDCS) Deaths 06 11 Schizophrenia Clinic 1823 1987 228445 247482 Metabolic Clinic 469 386 Centre for Addiction Medicine Telemedicine services: 671 957 New cases 2668 3215 Follow-ups 10218 12257 Legal Aid clinic - 272 Admissions 1091 1070 Family Psychiatry 441 381 Tele-consultations 4837 8158 Home Visits - 140 Grand Total 296314 323315 18814 24840 *Since October 2014 Extension Services Sakalawara 12232 9398 Gunjur 2185 2394 B. Specialist Clinics Services Gowribidanur 5876 5772 Maddur 2937 2740 Kanakapura 2831 2456 1. Centre for Addiction Medicine Madhugiri 3431 2175 Thuruvekere 549 462 The Centre for Addiction Medicine (CAM) continued to expand 30041 25397 its services during the year 2014-15. In response to the growing Electro-convulsive Therapy (ECT) services public demand for patient care, public awareness, community activity, New cases 882 752 research and policy, several new initiatives were initiated. Centre for Total number of sessions 6512 6636 Addiction Medicine Complex encompassing Women’s Treatment 7394 7388 Wing, Drug Toxicology Laboratory and Virtual Knowledge Centre was inaugurated by Dr. Harsh Vardhan, Hon’ble Minister of Health Obsessive-Compulsive Disorder (OCD) Clinic: 430 394 and Family Welfare, Government of India on 16 August 2014. New cases 1541 2061 Women’s Treatment Wing is an exclusive 20-bed facility for women Follow-ups with substance use disorders. This centre offers individualized care 1971 2455 in the form of medications, counselling, family interventions, and other client-based services. The Drug Toxicology Laboratory is fully Geriatric Clinic No. of elderly screened 2986 3457 equipped to carry out chemical tests to monitor drug abuse in patients No. of detailed evaluation 517 646 with addiction and/or psychiatric disorders. It has standardised 20 No. of follow up 2068 2503 different screening tests and HPTLC (High Performance Thin No. of admissions - 256 Layer Chromatography), GCMS (Gas Chromatography-Mass 5571 6606 Spectroscopy), ELISA based analysis of different drugs of abuse.
National Institute of Mental Health and Neuro Sciences 59| Annual Report 2014-15
Virtual Knowledge Centre has been established for the use of orientation course and advanced course in family therapy are also multipoint video-conferencing, and transmitting training sessions to offered by the Centre. During the year under review, faculty members various centres across India and the world. of the centre were involved in organising various programmes on family therapy in different parts of the country. A total of 310 families The Centre offers a comprehensive inpatient programme consisting were assessed in this period. of individual and family assessment, individually tailored treatments which involve pharmacological treatments for withdrawal and long 4. Geriatric Clinic & Services term prevention of relapse, individual and group counselling, family counselling and intensive aftercare. Geriatric Clinic is run as a special multidisciplinary clinic by the Geriatric Group in the Department of Psychiatry on Saturdays, from During the year 2014-15, CAM registered 3215 new patients and 2 to 6 pm. The elderly—above the age of 60 years—who register with followed up 12257 patients face-to-face and 8158 via telephone. A the screening outpatient service unit are screened for neuropsychiatric total of 1070 patients were admitted to the CAM in-patient ward disorders by the Geriatric Group. This is mainly to enable the elderly during the period for inpatient treatment. Five more beds (in single to avail appropriate services and get referrals at a faster pace. rooms) have been added to the existing 57-bedded male ward. The group/team comprises psychiatrists, neurologists, PM’s Mann ki baat (radio programme) on addiction: The CAM neuropsychologists, social workers, residents and trainees. On average, prepared a video on the importance of training experts in drug 12-15 new cases go through brief evaluation, and 8-10 elderly are abuse treatment cessation and sent it to the PMO in response to evaluated in detail—and about 20-30 follow-up patients are seen— the announcement inviting responses prior to the Honorable Prime every week. In the year under review, a total of 646 new cases were Minister’s address on addiction in the Mann ki baat programme. registered in the Geriatric Clinic. Besides, caregiver support group meetings are organized in this clinic to help caregivers. 2. Tobacco Cessation Centre (TCC) The Geriatric Group organised various programmes to mark the The multidisciplinary TCC team conducted a workshop on the use of celebrations of the World Alzheimer’s Month in September 2014 and tobacco use and related harm at the National Triple “O” Symposium, International Day for Older Persons 2014 (1 October 2014)—which MS Ramaiah Dental College. Awareness programme on tobacco included CME on “Dementia: Can we reduce the risk?” (jointly with related problems, behavioral counseling and treatment in collaboration Indian Psychiatric Society- Karnataka Chapter), talk on Early Signs with Central Board of Workers Education was also organised by the of Dementia in Old Age Home and Rotary Club, and workshop for team. IMA and CGHS doctors on Screening Elderly for Mental Health Issues. Aftercare Services & Vocational Rehabilitation The Geriatric Group collaborates with CGHS clinics in Bangalore CAM has dedicated manpower for aftercare and vocational and screens elderly at these centers for neuropsychiatric disorders. In rehabilitation. During the review period, 8158 telephone calls were addition, it works in partnership with with the NIMHANS Centre for made to the patients who were expected to come for follow-up and Well Being to provide counselling for the needy elderly and necessary 139 home visits were conducted to facilitate effective treatment assistance through the Elderly Helpline that was initiated in 2012. and enhance follow-up compliance of the patients. Sober patients The Geriatric Group also works actively with the Senior Citizen who reported to OPD were felicitated. Unemployed patients were Forum in South Bangalore in promoting positive and healthy ageing. motivated to work and placements were facilitated. Online automated software is being used by the aftercare team to maintain the database 5. Obsessive Compulsive Disorder (OCD) Clinic and send reminders to the patients about the follow-up. The OCD Clinic offers outpatient services every Tuesday from 3. Family Psychiatry Centre 9am to 1pm at the OPD block of NIMHANS. Severely ill and/or treatment resistant patients with OCD are routinely admitted to the The Family Psychiatry Centre offers both outpatient and inpatient wards for intensive pharmacological and psychosocial intervention. In family therapy services. The major services include family therapy, the year 2014-15, a total of 394 new cases were registered in the clinic marital therapy, and family intervention for different psychiatric and number of follow-up visits was 2061. A total of 116 patients were disorders. The centre conducts training programmes for trainees admitted for treatment. The clinic actively collaborates with other from NIMHANS and other institutes across the country in the field departments/services such as neuropsychology, molecular genetics, of psychiatry, psychology, psychiatry social work and nursing. Basic behavior therapy, and neuro imaging in research and clinical works.
60 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
The clinic has a website intended for public to know about OCD Marital Enrichment Services 42 51 and services rendered at the clinic (http://www.nimhans.kar.nic.in/ Right Choice Clinic (CAM) 35 21 ocdclinic/home.html). Aaraike and Child-Parent Well Being 74 86
6. Electro Convulsive Therapy (ECT) Services Stress Management and Lifestyle Clinic 55 72 Flourish Clinic (Positive Mental Health 41 31 Electroconvulsive Therapy (ECT) is a vital service, training and Clinic) research activity offered by the Department of Psychiatry. These Psychology Care Clinic 80 44 procedures are conducted in active liaison with the Departments of Asare (Parent Support Group) 57 59 Neuroanesthesia and Nursing. Every year, about 600-800 patients with Trauma Recovery Clinic - 27 severe psychiatric conditions receive this highly effective treatment. SHUT Clinic (Services for Healthy Use of - 24 This amounts to about 5000-6000 ECT sessions per year. The suite is Technology) equipped with the state-of-the-art EEG-ECG-monitored ECT with AWAKE - 12 advanced programs to analyze the EEG and ECG. The students are Grand Total 2334 2655 trained in all aspects of the ECT including pre-ECT evaluation, ECT administration, post-ECT care and ongoing medical and psychiatric 1. The Schizophrenia Clinic & the Metabolic Clinic in monitoring including cognitive adverse effects. More than 100 Psychiatry research papers have been published by the faculty in the area of ECT. In 2014-2015, the special clinical services of the Schizophrenia The department also has advanced Transcranial Magnetic Stimulation Clinic and the Metabolic Clinic have been integrated to formulate a (TMS) lab, where a number of investigational and therapeutic trials comprehensive programme – Individualized Schizophrenia Treatment of TMS are underway. TMS is being used clinically to treat different and Reintegration (InSTAR). The mission of InSTAR programme is disorders including depression, OCD, dissociative disorders, etc. to ensure a personalized clinical approach towards understanding and treating individuals with schizophrenia and related psychoses. The 7. Transcranial Direct Current Stimulation (tDCS) acronym InSTAR (“instar”) also means a “stage of change” reflecting the overarching goal of the InSTAR program to effect an “inclusive” Transcranial Direct Current stimulation (tDCS) is a neuromodulatory transformation with an emphasis on “individualization” of treatment technique that delivers low intensity, direct current to cortical areas approaches in schizophrenia. facilitating or inhibiting spontaneous neuronal activity. tDCS has adaptive neuroplastic effects and it is a safe procedure. So far, tDCS InSTAR programme comprises several components that involve an Lab at the Department of Psychiatry has completed more than 500 integrated multidisciplinary team of experts from psychiatry, psychiatric sessions of tDCS administration safely without any significant adverse social work, clinical psychology and yoga therapy. The primary special effects. Increasingly, faculties from all specialty clinics (Schizophrenia, services under the InSTAR program include: Schizophrenia Clinic Obsessive Compulsive Disorder, Geriatric Psychiatry, Center for and the Metabolic Clinic in Psychiatry. Depending upon the individual Addiction Medicine, Perinatal Psychiatry Clinic and Mood Disorders) requirements of the patients, through these special clinics, additional are in the process of initiating clinical research studies in tDCS with specific interventions like Yoga Therapy, Transcranial Direct Current an aim to integrate this with regular clinical practice. In 2014-15, a Stimulation (tDCS), Cognitive Therapies, Family Interventions and total of 57 patients have availed services of this lab. similar other specialized interventions are offered. To facilitate early identification and intervention for psychosis, a specialized clinical module– namely Objective Risk Assessment, Care and Liaison for Nimhans Centre for Well Being Early Schizophrenia (ORACLES)– is available. With the mission of “Reintegrating the Dis-integrated Self in Schizophrenia”, 2373 A. Clinical Services patients were treated in these special clinics.
No. of patients/cases 2. Genetic Counselling and Testing (GCAT) Clinic Facilities provided 2013-14 2014-15 GCAT is available as a part of the Movement Disorder Clinic Telephonic Enquiries 1206 1435 services on Saturdays of every month at NIMHANS OPD Block Total New Registrations 521 587 from 11.30 am to 1.00 pm. Genetic referrals for movement disorders Consultation Liaison Psychiatry 223 206 like Huntington’s disease (HD), Spinocerebellar Ataxia (SCA)
National Institute of Mental Health and Neuro Sciences 61| Annual Report 2014-15 and Friedreich’s Ataxia (FRDA) are counselled at this clinic. The to at least 254 patients who required emergency care for high-risk GCAT service has multi-disciplinary clinical staff from neurology, conditions. psychology, psychiatric social work, nursing and psychiatry in addition to the laboratory scientists. The service is tailored to each individual’s 4. Community Psychiatry Services counselling needs at the time of assessment or as requested. In 2014- 15, a total of 178 individuals and their families (HD-54/FRDA-25/ The Sakalawara Community Mental Health Centre (SCMHC) has SCA-99) availed the services for genetic counselling and testing for been the hub of all community mental health activities at NIMHANS. the movement disorders of which 74 individuals were confirmed by Located in a picturesque 13-acre land, at Sakalawara, Anekal Taluk, genetic testing (HD-25/FRDA-8/SCA1-14/SCA2-17/SCA3-8/ 18km away from NIMHANS main campus, SCMHC functions as SCA12-2). a short-term (~3months) residential rehabilitation center for persons with chronic mental illnesses. The clinic has provided 62 genetic diagnostic test reports (HD- 7, SCA1-4, SCA2-9, SCA3-3, SCA12-2, FRDA-7, Negative The Community Psychiatry Team of SCMHC provides residential result -30) to the patients and their families. The follow-up of the rehabilitation services, outpatient services, extension clinics (Camps), patients along with their families are continued through subsequent home, industry and school visits as well as telemedicine services. These visits to NIMHANS or by telephonic calls by GCAT staff. About services are delivered by a multidisciplinary team consisting of faculty, 35 patients or their families (HD-30 and SCA-5) wer e contacted specialist grade psychiatrists, senior residents, postdoctoral fellows, through telephone periodically to enquire and record their symptoms junior consultants, and trainees from the Departments of Psychiatry, and functional status (of these 4 individuals had expired). Functional Psychiatric Nursing, Psychiatric Social Work and Clinical Psychology assessment showed Independent scale scores >80 in 12 of these with the help of other administrative staff and vocational trainers. The subjects. centre runs outpatient services thrice a week for psychiatric disorders and epilepsy. About 10 new cases are evaluated in detail and 35 to 50 3. Emergency Psychiatry and Acute Care (EPAC) services cases are followed up in each outpatient clinic of the centre.
The Emergency Psychiatry and Acute Care (EPAC) services, Special lectures on health are given by the nursing team on continues to provide 24 hours care for patients presenting with Wednesdays and Fridays at the OPD. Residential services are provided psychiatric emergencies. EPAC services were utilized by 6970 patients in 22 cottages and the Mahabodhi building is dedicated to delivering from April 2014 to March 2015, at an average of 580 patients per therapies and vocational rehabilitation. The centre mainly provides month. Of these, 3613 patients (> 50%) were provided out-patient rehabilitation services to patients with severe chronic mental disorders. based ongoing care after emergency assessment and management— The rehabilitation programme consists of individual therapy, family which indicates the effectiveness of the EPAC service. therapy and group therapy for patients and caregivers. Individual therapy includes activities of daily living, social skill training, cognitive behavioral therapy, cognitive remediation, problem solving techniques, in-house vocation training as well as supported employment with the help of surrounding small scale industries and educational institutes. 24/7 inpatient services began in 2014 and 41 patients were admitted for residential treatment. This centre successfully completed 14 job placements and organised 38 family get-togethers, 16 day outs, and four festival celebrations for inpatients and their family.
The Centre conducted 2 to 6 home visits per month for the benefit of dropped out patients to ensure adherence and psycho-education. Regular industry and school visits are conducted to create awareness about mental health issues and find job placements of inmates of the residential centre. Telemedicine clinic for the benefit of inmates of Total Patients for EPAC Beggars Colony (on Magadi Road), Bangalore are run thrice in a month. Identifying the need for care for specific patients, EPAC has initiated the Priority Ward to manage patients with high risk to self and others, As in the past years, Extension Clinics (camps) are held at Kanakapura, SAFER (Safety and Facilitate Early Recovery) Ward and ASIST Gouribidanur, Madhugiri, Maddur, Gunjur and Anekal. Patient (Applied Suicide Intervention, Support and Treatment) Ward. This attendance in these camps varies from 150 to 400. These camps are facility, in the past 9 months of inception, has been able to cater now held on all Tuesdays. This is in keeping with the announcement
62 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 by the Hon’ble Chief Minister of Karnataka on the occasion of World clinically suspected SMA samples and 197 clinically suspected Mental Health Day 2014 that mental health clinics and services DMD samples). Molecular diagnosis was positive for 38 SMA would be made available in all the health centres of Karnataka State samples and 102 DMD samples. A total of 178 individuals and their on all Tuesdays. families availed the services for genetic counselling and testing for the movement disorders (HD/FRDA/SCA) of which 74 individuals were 5. Perinatal Psychiatry Services confirmed by genetic testing.
The Perinatal Psychiatric Services at NIMHANS is dedicated to 7. Consultation Liaison Services helping the mother, the mother-infant dyad, husbands and families who need treatment, support and guidance for any mental health The Consultation Liaison Psychiatry (CLP) services have seen increase problem related to pregnancy or child birth. Perinatal service in the referrals, indicating enhanced service and care offered by the provides both inpatient and outpatient care to the mothers and CLP team to the patients. Two new services were initiated last year baby. Outpatient services includes medication, psychotherapy, at SDS TRC & Rajiv Gandhi Institute of Chest Diseases, Bangalore counselling and education, family counselling, marital counselling, and the other at the NGO-funded Jnana Sanjeevani Medical Centre and interventions for mother-infant bonding problems including (Diabetic and Endocrinology Clinics). These services, which cater video enabled interventions. Inpatient services of perinatal psychiatry to both inpatients and outpatients, have seen consistent rise in the have Mother-Baby Ward with five beds and dedicated staff. Mothers number of referrals. Psychiatric care was also provided to patients by needing inpatient care are admitted here along with her baby. Apart CLP team at NIMHANS Centre for Well Being. The team was from usual treatment, specific focus is to facilitate mother-infant involved in various academic programs and workshops both within bonding and education on postpartum psychiatric disorders for and outside NIMHANS. mothers, spouses and family members. 8. Telemedicine Services Perinatal psychiatry services also focuses on training the postgraduate residents of psychiatry, psychology and psychiatric social work in Telemedicine is the delivery of healthcare services, where distance is clinical assessment of perinatal psychiatric syndromes, pre-pregnancy a critical factor, by all healthcare professionals using information and counselling for women with preexisting psychiatric illnesses and communication technologies for the exchange of valid information for post history of postpartum psychiatric illnesses, risk assessment for diagnosis, treatment and prevention of disease and injuries, research infant harm and self-harm, mother infant bonding assessment and and evaluation, and for the continuing education of healthcare interventions, use of psychotropic medication in perinatal period, providers, all in the interests of advancing the health of individuals and infant assessment. It conducts regular workshops and training their communities. The Telemedicine Network Project in Karnataka programs for doctors, nurses, mental health professionals, pediatricians state was introduced with a hope to bridge this gap and make and obstetrician to provide education and to increase the awareness specialist health-care reach populations in remote underserved villages. regarding perinatal psychiatry. Please visit the website of perinatal Telemedicine in Karnataka is currently a public sector initiative which psychiatry. has focus on tele-consultation, where the district hospital doctors initiates the consultation from the tertiary hospital on difficult cases for 6. Molecular Genetics Laboratory opinion on diagnosis and obtains the line of management. The tertiary hospital after receiving the request reviews the history and investigations Molecular Genetics Laboratory carries out research projects and and gives suggestions for further management. NIMHANS is one diagnostic work in neuropsychiatric conditions (schizophrenia, such tertiary institute providing the telemedicine services to 25 district bipolar affective disorder, obsessive compulsive disorder, dementia, hospitals of the Karnataka State. The Department of Psychiatry is Huntington’s disease, spino-cerebellar ataxia, Duchene’s/Beckers coordinating these services, which are operational for the past ten muscular dystrophy and spino-muscular atrophy). Till date, over years. The tele-consultation is pre-planned and on appointment basis. 14000 DNA samples from neuropsychiatric conditions and 1000 The whole tele-consultation is free for the end-user (patient). During control samples are stored at laboratory to facilitate research on the year, a total of 957 patients availed these services. candidate genes and epigenetic work for the purpose of research projects, PhD thesis, MD thesis and diagnostic work. 8. Free Legal Aid Services
Genetic testing for DMD/BMD and SMA is carried out by MLPA Persons with mental illness are often the weaker sections of the and PCR-RFLP methods respectively. The diagnostic work was society. Their basic human rights are many a time subject to violation. initiated as self-sustaining project from June 2014. A total of 275 Persons with disability, especially those suffering from mental illness individuals and their families utilized the diagnostic services (78 and mental retardation do not get proper attention in matters of
National Institute of Mental Health and Neuro Sciences 63| Annual Report 2014-15
access to justice. As a result, they are sidelined and viewed only from Evaluation of addiction cases 75 76 the prism of the paternalistic “social welfare” which looks upon them Follow-up of addiction cases 410 450 merely as persons who are in need of special protection by the State Evaluation of children and adolescent 240 554 and the society. psychiatry cases Follow-up: Child and adolescents and MR 390 122 Objective of the free legal aid clinic is to provide free services such clinic as legal advice, legal representation and legal adjudication free of Evaluation of mentally-handicapped child 184 368 cost. Patients seeking treatment at the hospital can utilize free and adolescents legal aid. Persons with disabilities can assert their rights using such Evaluation of cases at DPNR 252 168 clinics in matters such as disability certification, employment and Follow-up of cases at DPNR 204 72 pension. They can also defend their rights regarding admission to mental hospitals, human rights violation, treatment, property Evaluation of cases at Sakalawara Commu- NA 3 nity Mental Health Centre issues and marital issues. Women can be helped in issues such as sexual violence, domestic violence, property related issues etc. Therapy / Intervention Additionally, these kinds of services could help in making patients Behavioural medicine intake 743 871 aware of their rights and equip them to avail the benefits of the Behavioural medicine therapy 409 396 different social welfare activities sponsored by the State and Central Counseling, remediation and therapy of 300 402 Government. In this background, the Free Legal Aid Clinic has child and adolescent psychiatry cases been established at the NIMHANS, Bangalore. This service has Counseling of mentally handicapped 215 218 been constituted under the Legal Services Authorities Act, 1987. Adult psychotherapy and counseling 1358 Though the majority of clients are persons with mental illnesses, Family and marital therapy 382 394 the clinic is providing services to patients with neurological as well Marital enrichment therapy 42 51 as neurosurgical disorders. A total of 272 persons sought free legal CAM therapies 195 138 aid services during the year. Neuropsychological rehabilitation (Cogni- 105 63 tive retraining) Neurofeedback therapy 86 55 Child and Adolescent Psychiatry DPNR therapy - 76 A. Clinical Services DPNR evaluation - 168 DPNR follow-up - 72 No. of patients/cases General hospital intake - 82 Facilities provided 2013-14 2014-15 General hospital - 59 Child and Adol. Psychiatry cases screened 7063 7461 TBI evidence in the court 7 9 New files registered 2992 2561 New Services - Follow-ups 15240 18078 SHUT clinic(Service for healthy use of - 45 technology) Admissions 509 639 Evaluation of cases Sakalawara Community - 50 Casualty & emergency 57 99 Mental Health Centre - OP Grand Total 25861 28838 Evaluation - Community Camps - 30 Follow-up cases of Sakalawara Community 722 333 Mental Health Centre - OP Clinical Psychology Follow-up Camps - 151 Sakalawara Community Mental Health N.A. 21 A. Clinical Services Centre - IP Sakalawara Community Mental Health 321 76 No. of patients/cases Centre - OP Facilities provided 2013-14 2014-15 Camps - 44 Evaluation of adult cases 1100 1571 Stress and Lifestyle Clinic 55 72 Adult Psychiatry follow-up cases 7848 8361 Grand total 14285 16979
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B. Diagnostic Services operational on Thursdays (forenoon). The purpose is to facilitate interaction among parents, to understand parental issues and give No. of patients/cases suggestions. A total of 13 group sessions were held, in which 50 Facilities provided parents were seen. 2013-14 2014-15 Psychodiagnostic Assessment 854 964 The Trauma Recovery Clinic: The Trauma Recovery Clinic (TRC) CAM assessment 60 76 was described as one of the ‘Good Practices’ in Bangalore City for Intellectual assessment of child and adoles- 344 335 addressing interpersonal victimization and for stakeholders to cent cases with mentally handicap seek consultation related to ‘Gender Based Violence’ at the Swasti Assessment of intellectual Functions at 15 40 Health Resource Centre and United Nations Development Program IMRC (JHMRC) (UNDP) consultation workshop on ‘Gender Based Violence and Safe Psychological assessment of Child and 392 435 City’ on 24 March 2015 in Bangalore. A brochure about the clinic, Adolescent Psychiatry prepared after interviewing the consultants of TRC in 2014, was Assessment at Aadhara camp for children 250 63 printed by UNDP and Swasti Health Resource Centre and given to and adolescents with mental handicap all the participants at the workshop. The setting up of the clinic was DPNR Assessment 27 34 presented in International and National Conferences. Four workshops Neuropsychological Assessment (DPNR) 15 for counsellors were conducted by the clinic at NIMHANS Centre Neuropsychological Assessment 1954 1664 for Well-Being. IEC material on prevention of secondary trauma Sakalawara Community Mental Health N.A. 4 among nurses was prepared. A total of 27 clients sought consultation Center – IP in person and 25 through telephone. Sakalawara Community Mental Health 354 35 Center – OP Flourish Clinic: This is a one-to-one consultation service at the Camps - 145 NIMHANS Center for Well Being. It is run on a weekly basis on Sakalawara Community Mental Health 195 111 all Saturdays (except second Saturdays and general holidays) by the Center –Certificate for disability issued Positive Psychology Unit of NIMHANS. It caters to the concerns of Grand total 4445 3921 adults with felt needs for professional consultation for maintaining/ enhancing their wellbeing and functioning and self- development. From April 2014 to March 2015, 35 new clients registered for C. Specialist Clinic Services receiving consultation services at this clinic. The typical number of sessions per client this year ranged from 3 to 8. There was one group Community Mental Health Centre: Group therapy sessions for session for children initiated, attended by 9 children of these parents. in-patients and their caregivers at Sakalawara Community Mental Health Centre have been introduced from November 2014 and Service for Healthy Use of Technology (SHUT) clinic has been December 2014 respectively. These sessions are held on alternate started from May 2014 with the objectives of raising awareness weeks for each group. The goals of these sessions are tailored to the about technology addiction, creating manpower through workshops needs of the participants. The focus of patients’ group to date has and developing interventions. The mode of delivery of service been enhancing self-esteem and handling stigma while the focus of is psychological intervention for promotion of healthy use of caregivers’ group has been effective communication and coping skills. technology. The clinic has given various forms of intervention to Social Skills Training for patients in a group format has been started about 45 clients. from February 2015. Proformas have been developed for the facilitator rating of participants as well as the self-rating of participants in Stress Management and Lifestyle Clinic at the NIMHANS Centre group therapy. Approximately 18 in-patients and 16 caregivers have for Well Being (NCWB), which was started in 2011, is run by the participated in the group therapy sessions so far. Behavioral Medicine Unit and is operational on all Friday afternoons. It is aimed at offering stress management services to people from Aasare, a parent’s support group at NIMHANS Centre for Well different walks of life as well as for those who require help in Being began its service in 2013, the service is aimed at offering maintaining or achieving healthier lifestyles. The services are being parenting skills, and group based intervention for parents for children carried out by faculty members and PhD scholars of the Behavioral with behavioral, emotional and learning difficulties. The services Medicine Unit, Dept. of Clinical Psychology. MPhil Clinical are run by the Department of Clinical Psychology in liaison with Psychology trainees are posted on rotation as part of their behavioral the Department of Child and Adolescent Psychiatry. The clinic is medicine posting.
National Institute of Mental Health and Neuro Sciences 65| Annual Report 2014-15
A series of workshops have been conducted on academic stress, B. Diagnostic Services managing interpersonal relationships, understanding social anxiety and work stress for the urban community at the NCWB. No. of patients/cases Facilities provided 2013-2014 2014-2015 Psychiatric Social Work Digital Electroencephalography (EEG) 3386 3926 Visual Evoked Potential (VEP) 1232 1431 A. Diagnostic services Brain Stem Auditory Evoked Response 1195 1349 (BAER) No. of patients/cases Somato Sensory Evoked Potential (SSEP) 1206 1435 Facilities provided 2014-2015 Video EEG (VEEG) 450 515 Detailed work-up 4794 Polysomnography (PSG) 106 85 Follow-ups 10611 Electroneuromyography (ENMG) 2483 2350 IP 2621 Electrocardiogram (ECG) 2103 2077 OP 289 Electrocorticography 36 - Disability assessment 303 Intra Operative Monitoring (Video EEG) - 05 Group therapy 69 Grand Total 12197 13173 School mental health 15 Individual & family assessment 186 C. MEG: Screening 689 Home visits 12 Type of procedure: MEG Industrial visits 05 Family get-togethers 12 No. of patients/cases Facilities provided Psychosocial services 397 2013-14 2014-15 Supportive therapy 20 Epilepsy (Temporal & Extra - Temporal) 171 155 Collateral contacts 31 Absence & JME 004 036 Supportive therapy 20 Wilson’s disease 005 041 Day out 04 Alzheimer’s disease 000 011 Control (test) 007 005 Grand Total 187 248 II. Neurosciences Services
Neurology D. Specialist Clinic Services
No. of patients/cases A. Clinical Services Facilities provided 2013-14 2014-15 No. of patients/cases Neuro Muscular 743 797 Facilities provided 2013-14 2014-15 Epilepsy 458 576 Registration 20356 20101 Movement Disorder 203 370 Follow-ups 68193 74906 Dementia (in the Geriatric OPD of 495 1961 Admissions 4102 4461 psychiatry) Discharge 3731 3845 Stroke ward intervention number 38 19 Casualty (Emergency) 19026 19460 Grand Total 1937 3723 Deaths 195 168 Neuromuscular Disorders Clinic is a multidisciplinary specialty clinic Telemedicine 104 37 run on the fourth Saturday of every month. About 60-80 patients Grand Total 115707 122978 with various neuromuscular disorders visit this clinic. Genetic analysis
66 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 for Duchenne Muscular dystrophy and Spinal muscular atrophy with B. Diagnostic Services Genetic counselling is offered. OT CENSUS Epilepsy Clinic: About 30-50 patients with refractory epilepsy are Type of surgery No. of Cases 2014-15 seen in the Epilepsy Clinic, which is held on first and third Saturdays Vascular surgery Cranial 405 of every month. Treatment plans are made for the patient; in addition, education regarding marriage, employment, and free legal aid is Spinal 3 provided. Free drugs are distributed to deserving patients. Congenital anomalies Cranial 46 CVJ 57 Stroke ward encompasses five ICUs, five step-down and three special Spinal 46 wards. Patients with arterial, venous stroke are admitted and managed. Tumors Cranial supratentorial 748 Sizeable numbers of patients have been managed by thrombolysis,
Cranial infratentorial 333 decompressive craniotomy and other procedures. Spine 157 A protocol for acute ischemic stroke thrombolysis and venous Peripheral nerve 3 stroke management has been prepared and is being utilized. Patient Infection Cranial 149 education related activities and training of paramedical staff regarding triage of acute stroke is done. Spinal 48 Trauma Cranial acute 1156
Dr. SR Chandra, Professor, Department of Neurology, conducted Cranial delayed 32 free medical checkup for mentally disabled children, at Vatsalyam, CVJ 15 Kanyakumari, Kerala on 2 May 2014. A free medical camp was also Spinal 109 held and health education pamphlets distributed at Aleppey, Kerala on 25 January 2015. Peripheral nerve surgery Brachial plexus injury 43 Entrapment neuropathy 16 Movement Disorders Clinic is held on the first and the third Chronic subdural hemat- 307 Saturdays of every month and about 25-40 patients are seen in each oma OPD. Hundreds are treated with Botulinum Toxin and Deep brain Functional surgery DBS & thalamotomy 19 stimulation (DBS) is also offered by the Clinic. Epilepsy surgery 45 MVD for trigeminal neu- 41 Geriatric Clinic is conducted on all Saturdays except second Saturday ralgia and about 25 patients with dementias of varying etiology as well as Radiofrequency lesioning 1 their caregivers are seen and managed in a multidisciplinary way. for trigeminal neuralgia DREZotomy 3 Biopsy Stereotactic biopsy 66 Neurosurgery Brain biopsy 12 A. Clinical Services Endoscopic surgery 117 Shunt 697 No. of patients/cases Facilities provided Craniotomy for stroke 191 2013-14 2014-15 Spinal degenerative 246 Registration 20343 18032 disorder Follow-ups 39448 46687 GKRS 242 Admissions 6170 6562 Miscellaneous 160 Discharge 5445 5669 Emergency procedures on 1566 Casualty (Emergency) 17103 17539 bed side Deaths 540 510 Epidural Steroid Injection 35 Grand Total 89049 94999 Grand Total 7114
National Institute of Mental Health and Neuro Sciences 67| Annual Report 2014-15
Neuroanaesthesia B. Imaging Services:
A. Clinical Services No. of patients/cases Facilities provided 2013-14 2014-15 No. of patients/cases Routine X-ray examinations 23467 26950 Facilities provided 2013-14 2014-15 Ultrasound examinations 2411 3348 Anaesthesia in operation theatres Computed Tomography Scans 41114 45665 a)Elective operations 1852 1778 Magnetic Resonance Imaging 11099 14021 b)Emergency operations 2996 3257 Digital Subtraction Angiography 1236 1298 4848 5035 SPECT CT 265 68 Intensive care units Grand Total 79592 91350 Medical ICU 73 108 Surgical ICU 413 367 Emergency ICU 676 599 Speech Pathology & Audiology 1162 1074 Grand Total 6010 6109 A. Clinical Services
No. of patients/cases Facilities provided B. Diagnostic Services 2013-14 2014-15 Therapeutic services include individual 2950 4341 No. of patients/cases sessions, demonstration sessions for home Facilities provided based programs and group therapy ses- 2013-14 2014-15 sions for stuttering. Neuroradiological procedure done under 1609 1886 Number of Stuttering group therapy ses- - 47 sedation/GA sions held. Modified ECT 6512 6696 Grand Total 2950 4388 Grand Total 8121 8582 B. Diagnostic Services
C. Specialist Clinic Services No. of patients/cases Facilities provided 2013-14 2014-15 Pain Clinic, which was started in 2014, conducts various procedures Speech Language Pathology 3814 4290 to treat patients with RSD, trigeminal neuralgia, postdural puncture Audiology 1389 1753 headache, etc. A total of 20 patients were treated in the pain clinic, Grand Total 5203 6043 during the 2014-15. C. Specialist Clinic Services
Neuro Imaging & Interventional Stuttering group therapy: Group therapy sessions for stutterers are conducted on Saturday afternoons. During this reporting year, 47 Radiology sessions were conducted. On average 10-15 persons with stuttering attend the sessions. The group therapy focuses on adopting A. Intervention Services: strategies for communication as well as easy flow of speech. These interactive sessions have helped persons with stuttering to face the No. of patients / cases communication challenges more effectively. It has helped them to face Facilities provided the interviews and secure jobs, confronting strangers and engaging 2013-2014 2014-2015 in communication, answering questions in the class room as well as Neuro-interventions 122 145 conducting class seminars.
68 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
III. Rehabilitation Services SERWICE caters to the rehabilitation needs of patients with severe mental disorders (schizophrenia, bipolar disorder, severe obsessive compulsive disorder) and mental retardation. The patients are first evaluated in detail using the SERWICE proforma (designed by the Psychiatric Rehabilitation PRS team) keeping in mind their overall rehabilitation needs. Then each patient is allotted to one therapist (trainee). Under the supervision The Psychiatric Rehabilitation Services (PRS) are provided by a of PRS team members, the trainee would then provide comprehensive multidisciplinary team comprising faculty from Department of care for the patient till the time optimal functional recovery is reached. Psychiatry, Clinical Psychology, Psychiatric Social Work, Nursing; The therapist would be the main contact /liaison person for the patient. junior consultants; senior residents and post graduate students from In addition to pharmacotherapy, the therapist would be pivotal in both within and outside the Institute. providing a host of other services including psycho-education, individual psychotherapy, family therapy, cognitive retraining, vocational training, PRS caters to rehabilitation needs of patients in various settings: social skills training, physiotherapy, training in self-help skills, learning Day-care, inpatient, outpatient and referrals from psychiatry skills, behavioural modification, vocational counselling, etc. The trainee inpatient units. PRS has various vocational sections including would liaise with therapists from various treatment units so that smooth baking, printing, computer, candle making, weaving, crafts, co-ordination exists. This would also ensure continuity of care. Support plastic-moulding, carpentry, horticulture, tailoring, leather, etc. would be continued even after patients get into vocation. Active efforts Patients are trained in these vocations for varying periods of time would be made by the therapist to retain patients in follow-up. Sufficient and efforts. time for outpatient psychosocial interventions would be given during follow-ups. The advantages of SERWICE are as follows: (a) Longer A. Clinical Services consultation with their therapist (b) wide range of evaluations important for their recovery (c) wide array of interventions would be provided (d) No. of patients/cases contact with the same mental health professional (e) treating team to Facilities provided 2013-14 2014-15 be contactable through phone and email. In addition to the clinical services, the unit plans to evaluate outcomes of the followed-up patients. New day boarders 29 49 In-patient referrals to PRS 935 1040 In the year 2014-15, there have been 872 consultations in the SERWICE patients consultations(out-patient 738 872 SERWICE OPD. As on 31 March 2015, 162 patients were followed services) up by MD/DPM residents under SERWICE and periodically In-patient admissions specifically for 27 16 discussed with the faculty concerned. rehabilitation purposes (unit 4b admission) Psychotherapy 44 66 D. Special Initiatives for Patients Grand Total 1773 2043
Vocational training: During the year under review, Vocational Clinical Psychology Trainees did detailed evaluation of 53 patients, Training Courses in bakery, tailoring, printing and plastic moulding and followed up 72 patients. for persons with psychiatric disabilities were started (from February 2015). A total of 12 patients have been taken up for a cycle of three months. Fees for the courses have been waived off for BPL patients B. Diagnostic Services and those certified to be disabled. A stipend of up to Rs. 1000 per month is being paid to them. No. of patients/cases Facilities provided 2013-14 2014-15 Stipend has been hiked to Rs. 1000 per month for day boarders and IQ/ Neuropsychological Assessments/ 42 39 Rs. 700 per month for inpatients with effect from 1 March 2015. others Exhibition and sale of products from PRS: Denim bags prepared at the C. Specialist Clinic Services tailoring section of PRS, as a part of the PRS NIMHANS-Hundred hands initiative, were displayed and sold in the following events Services for Enhanced Recovery with Intensive and Comprehensive of Hundred Hands Trust: a) The Kala Ghoda festival at Mumbai, Engagement (SERWICE) is an out-patient service functioning since 7-11 February 2015 b) The Handmade Collective at Bangalore, 3-7 the past two and a half years. December 2014.
National Institute of Mental Health and Neuro Sciences 69| Annual Report 2014-15
of Independence Day, Republic Day, Ugadi, Ayudha Pooja and Christmas celebrations at the Institute.
Special programmes for patients and family members:
Sl.No Name of the activity Total 01 Health Education 48 02 Laughter Therapy 50 03 Mental Exercises 54 04 Sensory stimulation 47 Denim bags made by persons with psychiatric disabilities on display at the Handmade Collective Expo, Bangalore 05 Self Esteem building 44 06 Independent living Skills 53 07 Skill Development Program 52 Other activities: Various activities including ‘Pick a book’ campaign (where faculty and staff could pick a book of their choice at the 08 Pooja/Bhajan 41 book stand for purchasing PRS products worth Rs. 300 or more), 09 Story Telling 53 celebration of International Day of Persons with Disabilities 2014 and 10 Craft Session 49 World Mental Health Week/Day were organised. 11 Meditation 287
As part of the International Day of Persons with Disabilities 12 Exercises 287 celebrations, products (seven mats and four paintings) made by 13 Domestic skill Activities 154 patients of Psychiatric Rehabilitation Services were sold at the 14 Paper reading & Om Chanting 287 NIMHANS OPD. Posters prepared by clients attending daycare— 15 Recreational activity 45 under the guidance of Ms. Warsha Lath, professional artist and 16 Music/Dance Therapy 50 volunteer fine arts teacher—were also displayed at the OPD. 17 Art Therapy 94 On the occasion of World Mental Health Day, a street play on the 18 Indoor Games 51 theme for 2014 “Living with Schizophrenia” was performed. Poetry 19 Yoga 83 and essay writing competitions on the theme were also held. 20 Sanjeevini Vedike 12
A public talk on ‘Schemes and programmes by Department for Empowerment of Differently abled and Senior citizens’ for Persons with Disability (with special emphasis to PwD Act 1995)” was held on 24th June 2014 in Teaching hall, Second floor, DPNR building, NIMHANS. Mr. G Mohan, District Disability Welfare Officer (DDWO), Bangalore Urban District was the guest speaker. The programme was attended by 54 people including patients, caregivers, students and mental health professionals.
Job placements: Active efforts are being made to explore employment opportunities for adequately trained patients attending Psychiatric Patients attending psychiatric rehabilitation services taking part in various cultural events Rehabilitation Services. During the year 2014-15, a total of 7 candidates were placed in prominent organisations such as HCL (4); Patients attending psychiatric rehabilitation services actively Yashaswini Swavalambana Trust (1); Association of Persons with took part in various cultural events and sports/games held as part Disabilities (1); and Shankar Eye Hospital (1).
70 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Neurological Rehabilitation Step down ward 98 799 159 3151 Total (IP 2416 26702 2580 30734 A. Clinical Services patients) Grand total 8375 35550 9764 39592 1) Medical services: (IP &OP)
Consultations and ward-admissions in No. of patients/cases Dept. of Neuro-Rehabilitation 2013-14 2014-15 Services provided at Occupational therapy section Number of new referrals 8281 9332 Total no. of Patients Sessions Number of follow-ups 1329 1447 2013-14 2014-15 Number of admissions 223 228 No. of New Patients 2922 3407 Number of discharges 214 227 Follow-up sessions 11688 13628 Number of Health Education sessions 70 70 Treatments provided 46752 54512 conducted ADL sessions 1416 1800 Classes for trainees 12 11 Treatment provided 2832 3600 Neuro-muscular Clinic 328 419 Multisensory Therapy Grand Total 10457 11734 No. of sessions 212 620
Neuro-muscular Clinic 419 569 2) Para-medical services (Physiotherapy, Occupational Therapy Educational CD’s sold 4 4 and Orthotics) Robotic hand Rehabilitation 16 35 Out-patient services: Physiotherapy section Total no.of sessions 240 525 Total no. of patients/ treatment sessions Services provided by orthotic section 2013-14 2014-15 Activities No. of Devices made New Total New Total Appliances Referral treatment Referral treatment 2013-14 2014-15 OPD 3618 5922 4640 6103 Total no. of beneficiaries 177 175 NDT 1861 2446 1942 2128 Total no. of appliances made 359 352 Balance and gait Number of repairs and follow-ups done 06 12 9 65 14 39 training No. of follow-ups 13 03 Neuro-muscular No of patient benefited under CMMRF and 480 480 588 588 - 62 Clinic RAN scheme Total (OP 5959 8848 7184 8858 Grand Total 555 604 patients) B. Diagnostic services
In-patient services: Physiotherapy section No. of educational material No. of patients / Total no. of patients/ sessions (CIC Brochure ) given to the Facilities cases 2013-14 2014-15 patients Stations provided New Total New Total 2013-14 2014-15 January 2015-March 2015 Referral treatment Referral treatment Urodynamic 73 71 20 Rehabilitation 187 3866 2016 3911 studies MICU& SICU 270 6692 217 6640 C. Specialist Clinic Services Stroke ward 57 1707 85 1771 EICU 304 7797 260 8725 The Department of Neurological Rehabilitation runs the Other wards 1500 5841 1653 6536 Neuromuscular Clinic in association with the Department of
National Institute of Mental Health and Neuro Sciences 71| Annual Report 2014-15
Neurology on fourth Saturday of every month in the main OPD 23 Creatinine, Serum 58462 55642 building. A team consisting of consultants, resident doctors and 24 CSF Glucose 2243 6296 paramedical staff (physiotherapists, occupational therapists and orthotists) take care of rehabilitation needs of the patients with 25 CSF Lactate -- 1488 neuromuscular disorders. More than 400 patients benefitted with 26 CSF Protein 2243 6303 these services during 2014-15. Electrolytes - Serum, Urine (Na/K/ 27 76804 70291 Cl),CSF (Cl) 28 Fibrinogen, Plasma 46 54 IV. Laboratory Services 29 Folate, Serum 1277 2639 Gamma Glutamyl Transferase(GGT), 30 2351 2534 Serum Neurochemistry 31 Glucose, Serum 69566 55339 B. Diagnostic Services 32 HbA1c (Glycated Haemoglobin) 1274 2296 33 Hexosaminidase Total A & B, Serum 317 335 Blood, urine and CSF investigations: High Density Lipoprotein (HDL) 34 7283 8740 Cholesterol, Serum S.No. Parameters 2013-14 2014-15 35 Homocysteine, Serum 2063 3860 1 Albumin, Serum 25577 41741 36 Homocystinuria Screening, Urine 11 45 Lactate Dehydrogenase (LDH), 2 Alkaline Phosphatase (ALP),Serum 44829 42820 37 3005 987 Serum 3 Ammonia, Plasma 3343 4281 38 Lactate, Plasma 2874 3766 Angiotensin Converting Enzyme 4 515 673 (ACE), Serum 39 Lithium, Serum 4638 4725 Lupus Anticoagulant (LA) Screening, 5 Anti Thrombin, Plasma 13 56 40 5 7 Serum Anticardiolipin Antibodies-IgA, 6 42 15 Screening, Serum 41 Microalbumin, Urine 12 17 Anticardiolipin Antibodies-IgG, 42 MPS Spot Test, Urine 11 25 7 42 30 Screening, Serum 43 Myoglobinuria Qualitative, Urine 30 48 Anticardiolipin Antibodies-IgM, 8 49 31 44 Osmolality ,Urine 4326 2919 Screening, Serum 3019 Antiphospholipid Antibodies IgG, 45 Osmolality, Serum 4193 9 589 664 Screening, Serum 46 Phenobarbitone (PB), Serum 70 44 Antiphospholipid Antibodies IgM, 10 589 651 47 Phenytoin, Serum 223 262 Screening, Serum 48 Phosphorus Inorganic, Serum 6136 2599 11 aPTT 1555 7024 49 Porphobilinogen Qualitative, Urine 581 282 12 Aryl Sulfatase A , Serum 214 322 50 Protein 24 Hours, Urine 24 27 Abnormal metabolites Screening , 13 1903 2151 Urine 51 Protein-C, Plasma 24 73 Bence Jones protein Screening, 52 Protein-S, Plasma 24 73 14 601 535 Urine 53 Prothrombin Time (PT) 2414 8282 15 Bilirubin Total, Serum 45578 43071 Screening for IEM by Tandem Mass 54 3558 4602 16 Calcium, Serum 8446 5536 Spectrometry(TMS) 17 Carbamazepine (CBZ), Serum 318 266 55 SGOT (AST), Serum 44998 43000 18 Ceruloplasmin, Serum 562 589 56 SGPT (ALT), Serum 44969 42998 19 Cholesterol Total, Serum 7362 8754 57 T3 (Triiodothyronine), Serum 7780 9361 20 Copper 24 hours, Urine 304 278 58 T4 (Thyroxin), Serum 7787 9338 21 Copper, Serum 597 661 59 Total protein, Serum 24145 41771 22 Creatine Kinase (CK),Serum 6329 4265 60 Triglycerides, Serum 7240 8733
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TSH (Thyroid Stimulating Hormone), 24 Blood cultures 890 143 61 8160 9954 Serum 25 Oligoclonal band and monoclonal 62 Urea, Serum 57369 55239 gammopathy: IgG 511 546 63 Uric Acid, Serum 1247 1114 IgA 511 546 IgM 511 546 64 Urobilinogen Qualitative, Urine 4 24 26 Anti-acetylcholine receptor antibod- 206 205 65 Valproate, Serum 851 910 ies: Direct 66 Vitamin B 12, Serum 4209 6553 27 Vitek-2 Compact-60 591 1004 Grand Total 614204 641028 28 BACTEC MGIT 878 269 29 BACT ALERT 1050 956 30 BD FX40 - 1235 Neuromicrobiology Investigations – Hospital Infections Surveillance System B. Diagnostic Services 31 Blood bag sterility check - NIMHANS 468 516 32 CSSD sterility check 25 30 Sl. No. of patients/cases Facilities provided 33 OT sterility 26 26 No. 2013-14 2014-15 34 Water analysis 28 51 1 CSF cell count 6021 6439 35 Screening of other sites: Throat, 254 314 2 CSF cytology 1440 953 Axilla, Groin 3 CSF cultures 2782 3463 36 MRSA screening 2138 1861 4 Pus cultures 113 120 37 Red Cross Blood bag sterility 920 884 5 Routine cultures 6223 7230 Grand Total 56190 60421 6 Fungal cultures 2733 2977 7 AFB cultures 2412 2433 8 Serum ASLO determinations 52 356 Neuropathology 9 CRP determinations 103 169 10 Serum Widal test 332 408 A. Clinical Services 11 Serum Rheumatic Factor test 2731 2906 12 Blood VDRL 4093 3859 (1) Transfusion Medicine Section 13 CSF VDRL 2638 2925 14 CSF – antimycobacterial antibody test 2495 2679 No. of patients/cases Facilities provided by ELISA (MTSE) 2013-14 2014-15 15 CSF - mycobacterial immune complex 2495 2679 Blood donations (Donors) 7057 6886 of IgG type Blood and blood components collected 14589 13977 16 CSF – mycobacterial immune complex 2495 2679 Blood Donation Camps attended 73 66 of IgM type Blood and blood components issued 14968 13390 17 CSF - anticysticercal antibody using 2495 2679 Antigen-B Blood and blood components issued to 5037 4431 other hospitals 18 India ink for Cryptococci 2648 2854 Phlebotomies done for the Patients 132 108 19 Mantoux test 123 157 Small Volume Plasmapheresis 361 318 20 Serum antinuclear antibody test 2659 2892 Large Volume Plasmapheresis 2386 1890 21 CSF latex agglutination test for Cryp- 46 326 tococcal antigen ABO grouping and Rh Typing 50134 47361 22 Serum/CSF Toxoplasma test by latex 42 88 Hemoglobin estimation done for Blood 8101 7714 agglutination Donors 23 Koch’s spine 09 18 Grand Total 102838 96141
National Institute of Mental Health and Neuro Sciences 73| Annual Report 2014-15
2) Clinical pathology & Hematology Section (2) Electron Microscopy Section
No. of tests No. of cases Investigations Facilities provided 2013-14 2014-15 2013-14 2014-15 Hemogram 48863 51619 382 610 Ultrastructural studies Peripheral Smear 9784 9860 NIMHANS Referral NIMHANS Referral Peripheral Smear for MP 706 417 Diagnostic Electron 100 130 229 145 ESR 17001 12552 Microscopy BT/CT 1195 Tests discontinued Research 102 50 141 69 from February 2014 Samples submitted for AEC 279 77 light microscopic stud- 26 26 ies (Only Semi-thin) ANC 114 81 Reticulocyte Count 97 66 (3) Autopsy service Sickling Test 103 112 Saline Dilution Test 57 69 Autopsies 2013-2014 2014-2015 Bone Marrow Study 14 13 Clinical Autopsies 19 26 Urine Examination 5310 4424 Medico legal Autopsies 329 368 Stool Examination 124 111 Grand Total 348 394 Research Project 273 217 Total 83920 79618 Department of Neuropathology: Summary of tests done
Section Number B. Diagnostic Services 1 Histopathology 14806 2 Transfusion medicine Centre 96141 (1) Histopathology Section 3 Clinical Pathology 79618 4 Electron microscopy 610 2014-2015 TOTAL Diagnostic Work 5 Autopsy 394 NIMHANS REFERRALS 2013-14 2014-15 Grand Total 191569 Neurosurgical 1775 2396 3816 4171 Neurology 1006 2370 3520 3376 Stereotactic Biopsy 21 7 53 28 Neurovirology Muscle 592 973 1374 1565 Nerve 191 1259 1313 1450 B. Diagnostic Services Skin 113 102 223 225 No. of patients/cases Liver 1 6 11 7 Facilities provided Brain biopsy 22 59 81 81 2013-14 2014-15 Muscle - 592 460 903 1052 Laboratory diagnosis of Histochemistry Japanese Encephalitis 260 292 Dengue 781 982 Immunohistochemistry 944* 1616 * 2249 2560 Chikungunya 301 582 for Tumor Diagnosis (2889)# (5228)# Rabies 266 302 Muscle 224* 67* 244 291* Measles 249 278 Immunohistochemistry (1296)# (292)# (1588)# Herpes encephalitis 408 468 Grand Total 5481 9315 13787 14806 Total 2265 2904
[* - total number of cases, #- total number of tests]
74 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Enterovirus 25 51 Community Mental Health H1N1 542 2820 Services provided at Sakalwara Centre HIV 4771 4194 New Cases 2557 305 CD4 15,019 17666 Old Cases 6320 4898 Early infantile diagnosis (EID) 3868 1951 Home Visits 110 24 HIV viral load 938 - Hepatitis B 1033 1292 Extension Clinics (New & Old cases) 22486 16595 Total 26196 27974 Rehab Centre Grand Total 28461 30878 Admissions - 25 Discharge 19
Dr. SN Madhusudana, Professor, Dr. Reeta Mani, Assistant Professor, CSSD No. of Gas Sterilization done 405 980 and Dr. Ashwini MA, Sr. Resident conducted rabies awareness and No. of Sets Sterilized 136204 161800 vaccination campaign as part of the outreach programme at Mysore, Grand Total 279124 303828 three times during September-October 2014 for schoolchildren of Tibetan Monastery. The campaign was also held at Rani Sarala Devi High School, Bangalore on 12 March 2015, in 500 schoolchildren took part. B. Diagnostic Services
No. of patients/cases Facilities provided Neurophysiology 2013-14 2014-15 Samples sent to different laboratories for B. Diagnostic Services various investigations from the following areas No. of patients/cases Neuro Centre Wards 211315 119225 Facilities provided 2013-14 2014-15 Psychiatric wards including Casualty and Emergency Services 129866 133614 Autonomic Function Tests 857 928 Grand Total 341181 252839 Pulmonary Functions Tests 388 422 Grand Total 1245 1350 C. Specialist Clinic Services
V. Supportive Services Details of the services provided to the clients:
No. of patients/cases Nursing Facilities provided 2014-15 A. Clinical Services Drop in enquiries and Telephonic 1435 enquiries No. of patients/cases Total registered clients 587 Facilities provided 2013-14 2014-15 Number of clients consulted CLP 206 Acute Nursing Care 11391 11033 Number of clients seen by Stress 72 Intensive Nursing Care 12746 11225 management and lifestyle management team ECTs 6492 6705 Number of clients seen by Marital 51 Emergency Nursing Care Enrichment Service team Neurology 28046 28733 Neurosurgery 24516 26337 Number of clients seen by Family 86 Psychiatry 9114 10333 enrichment/ Parenting training/Student & Adolescent Stress Chronic Patient Care 13830 19720 management/ No. of Surgeries Assisted 4907 5096 Occupational Stress management team
National Institute of Mental Health and Neuro Sciences 75| Annual Report 2014-15
2. A special Geriatric OPD is being run by the Institute, every Number of clients seen by Positive 31 Psychology team Tuesdays. The data of patients who attended the Geriatric OPD during the reporting year is as follows: Number of clients seen by De-addiction 21 team Number of clients seen at Psychology clinic 44 Number of Patients Attended Asare (Parent support group) 59 New Old Grand Total Trauma Recovery clinic 27 Male Female Male Female Male Female SHUT Clinic (Services for Healthy Use of 24 405 301 440 340 845 641 Technology) Awake clinic 2 3. A special OPD has been started by the institute (from February Grand Total 2645 2015) for treating flu-like illness and the data of the patients who attended the OPD during the reporting year is as follows:
Number of Patients Attended VI. Ayush Services Adult Children Grand total Male Female Male Female Male Female Ayurveda 08 13 03 03 11 16 Hospital Services Advanced Centre For Yoga – Outpatient services are offered on a regular basis at the main OPD Mental Health & Neurosciences block of NIMHANS. Patients with various neurological and psychiatric disorders are provided with specialised consultations and The Advanced Centre for Yoga - Mental Health and Neurosciences treatment. Number of patients treated during 2014-15 at OPD and was started in 2007 in collaboration with the Morarji Desai National IPD are as follows: Institute of Yoga, New Delhi (funded by the Department of AYUSH, Govt. of India) for promoting training and research in Yoga. Activities New Follow Up Admissions Discharges Death Emergencies of the centre were essentially interdisciplinary involving all clinical 4737 4130 257 248 00 00 and many basic science departments.
Special Clinics (OPD) & Services: The center completed its original term in March 2012 and functioned in a limited capacity as a service till June 2014. In July 2014, the 1. A special clinic is held on fourth Saturday of every month in NIMHANS Integrated Centre for Yoga (NICY) was established to association with the Department of Neurology. Ayurvedic continue service, training and research activities related to yoga in medications are provided and improvements in health mental health and neurosciences. conditions of patients are assessed through regular follow-ups. During the reporting year, 906 patients of Neuro – muscular The following clinical services are currently being offered to patients disorders are treated at OPD level. and caregivers referred from NIMHANS clinical services:
NEW OLD • Yoga therapy services for psychiatric and neurological patients Disease/ TOTAL Adult Child Total Adult Child Total referred to NIMHANS Integrated Centre for Yoga Disorder M F MC FC M F M F MC FC M F M F • Regular yoga classes for inpatients at psychiatric wards of DMD 20 5 108 6 128 11 57 8 259 11 316 19 444 30 NIMHANS through trained nursing staff. LGMD 25 10 1 3 26 13 56 16 6 2 62 18 88 31 • Regular yoga sessions for caregivers of patients with psychiatric BMD 9 0 3 0 12 0 15 0 6 0 21 0 33 0 and neurological disorders. MND 9 2 0 0 9 2 16 2 0 1 16 3 25 5 SMA 2 0 5 2 7 2 22 4 6 4 28 8 35 10 Yoga sessions at Psychiatry Wards Mamsavata 65 26 17 10 82 36 53 19 9 6 62 25 144 61 (Unspecified) Grand The Centre is also running daily yoga classes at different psychiatric 130 43 134 21 264 64 219 49 286 24 505 73 769 137 Total wards through nursing staff trained in Yoga. A yoga-based session with
76 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 selected yogic asanas, pranayama and nadanusandhana techniques has family members with mental retardation, Sotos syndrome, Turners been introduced in place of unstructured physical activity at both open syndrome, Downs syndrome and patients with brain and nervous and closed psychiatric wards. An average of about 15-20 patients system tumors such as glioblastoma multiforme, neurofibromatosis participate in these yoga based sessions. An average of about 15-20 (type 1 and type 2), hemangioblastoma, medulloblastoma and patients participate in these yoga based sessions. meningioma were counseled. Karyotype data of three families who suffer from persistent familial mental retardation for three generations Training activities was examined. Appropriate information was given to them about the genetic conditions running in the family. They were educated NICY conducted three Yoga Appreciation Courses lasting one month on the recent advancements in diagnosis, therapy, and management each for staff and students of NIMHANS from December 2014 – available for genetic conditions/disorders. Based on this information March 2015 in which more than 50 persons participated and received the individuals from these families were advised on their reproductive training in yoga. This was highly appreciated by the staff and students choices. A total number of 14 patients benefited from this service. who attended, and NICY has planned to make this a quarterly feature in the coming year. Mental Health Education The Centre has also developed a video CD with the full yoga module for Schizophrenia for patients who have already been trained by the A. Clinical Services yoga therapists, which is being used for video sessions at the Centre as well as home sessions. Similar video tools are being developed for Digital Display: A customizable digital display system has been other disorders. A pilot tele-yoga session was recently trialed, which installed at the OPD and Casualty. This system is programmed for has potential for continued supervised training for patients who specific content needs of the clients through a computer connected cannot attend the Centre. to LAN (Local Area Network) and real time data such as hospital statistics, inpatient strength, availability of beds, laboratory charges, As a pilot project for mental hospitals in India, the Centre also etc. are displayed. Display contents at various outpatient waiting halls conducted a brief training course for two nurses from the Dharwad are customized to the requirement of the patients and caretakers. Institute of Mental Health and Neurosciences (DIMHANS) to teach specific Yoga modules to patients with mental disorders in March Feedback about the display system is being collected from viewers 2015. The Centre plans to expand this program to cover all mental and non-viewers on mobile devices using the Open Data Kit by the hospitals in India in collaboration with the Department of Nursing, Department of Mental Health Education. NIMHANS.
VII. Other Services
Human Genetics
A. Clinical Services
Facilities provided No. of patients 2014-15 Genetic counseling 34
B. Diagnostic Services
Facilities provided No. of patients 2014-15 Karyotyping 12 Video Clips for Digital Signage at OPD: C. Specialist Clinic Services The department, in collaboration with clinical departments, routinely Genetic counseling (online and in person) was provided for produces content to meet the needs of various OPDs. Video clips on patients referred for risk assessment and karyotyping. Subjects and the following were produced:
National Institute of Mental Health and Neuro Sciences 77| Annual Report 2014-15
1. Keeping the hospital environment clean Posters, Brochures, Graphics & Illustrations
2. Sakalwara Community Mental Health Services Particulars Numbers 3. Flora and fauna of NIMHANS Graphics 291 4. Flowering trees of NIMHANS Posters 40 Brochures 7 5. Stroke prevention Images for manuals 145 6. ROSeS - Recovery oriented services Cover page /CD cover Designs 2 Digital ID cards 483 7. Residential rehabilitation services at Sakalwara Community Mental Health Services Lamination of posters 467 Flip chart 1 In addition, the following videos were also produced: Education Materials Issued 516
Department of Clinical Psychology: Demonstration of social skills Poster exhibitions were held to commemorate World Mental Health assessment (2 videos, 20 minutes each). Day, World Brain Day, World Organ Donation Day, World Suicide Prevention Day, No Tobacco Day, and Stroke Prevention Day. Department of Nursing: Guided two MSc students on video Health education materials are regularly displayed at the OPD, in production, shot and edited videos for their thesis- Stress Management collaboration with Department of Nursing. (15 minutes); Management of Violent Behavior (15 minutes); Role play on Maternal Mental Health (20 minutes). Posters for patients and caregivers were developed which include: (a) Role of caregivers in taking care of persons with Schizophrenia Department of Psychiatry: Yoga for Schizophrenia (60 minutes)- - Single poster - English and Kannada (b) Encouraging recovery in demonstration video for patients with schizophrenia; Video for Yoga Schizophrenia - single poster- English and Kannada (c) Understanding Appreciation Course (120 minutes – 3 modules); An introduction Schizophrenia, English and Kannada (d) Organ donation - 4 posters to NIMHANS (9 minutes); Demonstration of administration of (e) Suicide Prevention - 6 posters (f ) Stroke Prevention - 2 posters MINI, (Adult ) Version - a psychiatric structured diagnostic interview (g) Aadhar Poster - Development in Children (h) Yoga Services at instrument for the National Mental Health Survey; Demonstration NIMHANS for Advanced Centre for Yoga, Department of Psychiatry of administration of MINI KID, for the Department of Child and (i) Services at Department of Neuro Rehabilitation, NIMHANS (j) Adolescent Psychiatry. Spectrum of Epilepsy Surgery in Children, Department of Neuro Surgery, NIMHANS Department of Mental Health Education: First Aid in Epilepsy (4 minutes): This training video is intended for teachers, students, Brochures prepared for patients included: (i) Department of community health workers anganwadi workers and volunteers. Neuro Rehabilitation: a) Self-Stretching Exercise (b) Exercise for Frozen Shoulder (c) Exercise for Bell’s Palsy at Home (d) Exercise Department of Neuropathology: Procedure for Blood Donation (15 for Pre-Arthritic Shoulders (e) A Guide for Clean Intermittent minutes): The video demonstrates procedures to follow during blood Catheterization (CIC) for Men and Women (ii) Yoga Centre: OCD donation for doctors and lab technicians. and Depression in Kannada, English and Hindi.
78 | National Institute of Mental Health and Neuro Sciences
Annual Report 2014-15 Human Resource Development
A. Postdoctoral Fellows Mr. P Chandrasekar Tamil Nadu Mr. Jobin Tom Kerala Ms. Kavitha P Karnataka 1. Dr. Shashidhara HN, Acute Care and Emergency Psychiatry Ms. Kimneihat Vaiphei Manipur 2. Dr. Aniruddha Basu, Addiction Medicine Ms. Pooja Mohanty Odisa 3. Dr. Arun Vangili, Child & Adolescent Psychiatry Mr. Thippeswamy V Karnataka 4. Dr. Gayatri Saraf, Consultation Liaison Psychiatry 5. Dr. Kommula Lakshman Kumar, Neuroanaesthesia 8. Speech Pathology & Audiology: 1 6. Dr. Nidhi Rawat, Neurological Rehabilitation Ms. Neeraja Karthi Karnataka 7. Dr. Santhosh NS, Neurology (Epilepsy) 8. Dr. Anirudhan TN, Neuropathology 9. Dr. Shrithi Karanth MP, Neuropathology II. DM (Neurology): 6 Dr. Anil R Karnataka Dr. Anish L Kerala Dr. Divya Raj R Kerala B. Qualifications Awarded Dr. Jaychandran R Tamil Nadu Dr. Mirza Masoom Abbas Karnataka I. PhD Dr. Ravinder Jeet Singh Uttar Pradesh
1. Biophysics: 2 III. DM (Neuroimaging & Interventional Mr. Bhanu Prakash Tewari Uttarakhand Radiology): 2 Ms. Biji Jose Karnataka Dr. Bhaskar MV Karnataka Dr. Vinay Hegde S Karnataka 2. Biostatistics: 1 Mr. Kamal Kishore Himachal Pradesh IV. DM (Child & Adolescent Psychiatry): 2 Dr. Preeti Jacob Karnataka 3. Clinical Psychology: 5 Dr. Preeti Kandasamy Tamil Nadu Ms. Anindita Bhattacharya Rajasthan Ms. Anisha Mary Abraham Karnataka V. DM (Neuroanaesthesia): 1 Ms. Meghna Singhal New Delhi Dr. Vinay B Karnataka Ms. Selvi Kumari R Tamil Nadu Ms. Urvashi Anand Delhi VI. M.Ch (Neurosurgery): 6 Dr. Amrit Kumar Saikia Assam 4. Neurochemistry: 2 Dr. Arun Babu R Tamil Nadu Ms. Maya Mathew Kerala Dr. Gunal V Karnataka Ms. Tanima De Jharkhand Dr. Manish Beniwal Haryana Dr. Nishanth S Karnataka 5. Neurophysiology: 1 Dr. Padwal Amit Dattatray Maharashtra Ms. M Nirmala Karnataka VII. MD (Psychiatry): 13 6. Psychiatry: 1 Dr. Aditi Singh Uttar Pradesh Mr. Sunil Kalmady Vasu Karnataka Dr. Aneelraj Karnataka Dr. Aniruddh Narasimha Karnataka 7. Psychiatric Social Work: 8 Dr. Bharath Holla Karnataka Mr. Apurba Saha West Bengal Dr. Lekhansh Shukla Madhya Pradesh Mr.T Arul Roncalli Karnataka Dr. Manjula A Tamil Nadu
80 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 Annual Report 2014-15
Dr. Miriyala Srikanth Andhra Pradesh XIV. MPhil (Psychiatric Social Work): 11 Dr. Nandeeshwar Reddy Mopuru Andhra Pradesh Ms. Anila Michael Kerala Dr. Rajendra KM Karnataka Mr. Ashok S Kori Karnataka Dr. Sajal Sathiadevan Kerala Ms. Candice Genevieve Menezes Maharashtra Dr. Sonia Shenoy Karnataka Ms. Chandni A Chandran Kerala Dr. Srikanth Karnataka Ms. Meiya Varghese Kerala Dr. Vijay Danivas Karnataka Mr. Nibin Paul P Kerala Ms. PS Yurthingla Manipur VIII. Diploma (Psychiatry): 8 Ms. Rajani A Kerala Dr. Alok Vinod Kulkarni Karnataka Mr. S Sudhir Babu Andhra Pradesh Dr. Karthik S Karnataka Ms. Sphoorthi G Prabhu Karnataka Dr. Lavanya P Sharma Karnataka Ms. Supraja TA Tamil Nadu Dr. Madhuri HN Karnataka Dr. Prabhath Kodancha G Karnataka XV. MSc (Psychiatric Nursing): 6 Dr. Prabhu Jadhav Karnataka Ms. Ann Deva Priya J Tamil Nadu Dr. Priyanka Prabhakaran Karnataka Ms. Diksy Jose Kerala Dr. Sujai R Karnataka Mr. Kannan K Tamil Nadu Ms. Lija KL Kerala IX. MPhil (Biophysics): 3 Ms. Mrudula G Karnataka Mr. Ajay Raghunath Irmale Maharashtra Ms. Rajitha P Andhra Pradesh Mr. Prashant Vasant Deshmukh Maharashtra Mr. Yuvraj Joshi Uttarkhand C. Degrees Awarded (In-Person) X. MPhil (Neurophysiology): 2 st at 1 Graduation Day Ms. Merlin PB Kerala Dr. Rukmani MR Karnataka I. BSc (Nursing): 26 Ms. Akhila V Joseph Kerala XI. MPhil (Neurosciences): 1 Ms. Amala Thomas Kerala Ms. Sharmistha Naskar West Bengal Ms. Anjali Thomas Kerala Ms. Anjaly Baby Kerala XII. MPhil (Mental Health & Social Psychology): 1 Ms. Anju Rose Thomas Kerala Mr. Vadela Israel Andhra Pradesh Ms. Athira Antony Kerala Ms. Chinchu Thomas Kerala XIII. MPhil (Clinical Psychology): 16 Ms. Diliya George Kerala Ms. Amrita Biswas West Bengal Ms. Divya Paul Kerala Ms. Anupama Vijayaraghavan Kerala Ms. Elsa N Varkey Kerala Ms. Asha Ravi Kerala Ms. Elseena Baby Kerala Ms. Athulya Jayakumar Kerala Ms. Honey Kurian Kerala Mr. Dinakaran P Tamil Nadu Ms. Jainy Vincent Kerala Ms. Fasli Sidheek KP Kerala Ms. Jini George Kerala Ms. Hargun Ahluwalia New Delhi Ms. Josna Johny Kerala Ms. Lalhmingmawii Mizoram Mr. Kailash Kumar Meena Rajasthan Ms. Mallika Batra New Delhi Ms. Maria Udhippu Kerala Ms. Meghana Vijayanand Karnataka Ms. Neenet P Cheriyan Kerala Mr. Mohd. Afsar New Delhi Ms.Neenu Sara Abraham Kerala Mr. Shiju Joseph Kerala Ms.Reshma K Mahima Kerala Mr. Shyam HR Karnataka Ms.Shiny Maria John Kerala Ms. Sisira C Kerala Ms. Silmi Thomas Kerala Mr. Subhash Chandra Singh Uttar Pradesh Ms. Sona PP Kerala Mr. Sujith Babu Kerala Ms. Stephy Xavier Kerala
80 | National Institute of Mental Health and Neuro Sciences National Institute of Mental Health and Neuro Sciences 81| Annual Report 2014-15
Ms. Treesa MV Kerala IV. MD (Psychiatry): 3 Mr. Venu MA Karnataka Dr. B Shanmuganathan Tamil Nadu Dr. Chandrashekar B Huded Karnataka II. BSc (Radiography): 7 Dr. Vidya Narayan Karnataka Mr. Antony CV Kerala Mr. Bopanna KS Karnataka V. MPhil (Neurosciences): 2 Ms. Harsha Roy Kerala Ms. Divya Narayanan Kerala Mr. Jabir PE Kerala Ms. Pratibha Bharti Bihar Ms. Pratima Singh Arunachal Pradesh Mr. Sajin Kodalikkuth Kerala VI. MPhil (Mental Health & Social Psychology): 1 Mr. Shabeer K Kerala Ms. Jini KA Kerala
III. BSc (Anaesthesia Technology): 3 VII. MPhil (Psychiatric Social Work): 3 Ms. Amala Raj S Kerala Ms. Ranjana Stanly Kerala Ms. Anila Mammen Kerala Ms. Saritha VR Kerala Ms. Jansi T Tamil Nadu Ms. Smruti Lekha Dash Odisha
D. Qualifications Awarded In- E. Qualifications Awarded at the th Absentia at the 19 Convocation Institute Day Celebrations
I. POST DOCTORAL FELLOWS I. Diploma in Clinical Neurophysiology 1. Dr. A Sugaparaneetharan, Addiction Medicine Technology (DCNT): 6 2. Dr. Pooja H Shetty, Community Mental Health Ms. Dhanisha V Kerala 3. Dr. Sabina, Neuroanaesthesia Ms. Haneez Beegum S Kerala 4. Dr. Nitin Ajitkumar Menon, Neurological Rehabilitation Sri. AS Karthick Tamil Nadu 5. Dr. S Revathi, Psychosocial Support Disaster Management Ms. Nissy Annamma Varghese A Kerala Ms. Resmit HA K Kerala II. PhD Sri. V Vijaya Kumar Pondicherry
Biophysics: 1 II. Post-Basic Diploma (Psychiatric/Mental Health Mr. Mahendra Singh Uttarakhand Nursing): 17 Ms. Chhaya Mohan Bhambal Maharashtra Neurochemistry: 2 Mr. D Franklin Rajarajan Tamil Nadu Mr. Harish G Karnataka Sri. Jiji John (Elseena CSS) Kerala Mr. Rakesh Sharma Karnataka Sri. Anush C Nair Kerala Ms. N Bhagya Karnataka Clinical Psychology: 1 Maj. Bindu AK Kerala Ms. Shereena EA Kerala Mr. Jis Tom Kerala Ms. Manasi Ganesh Dukhande West Bengal Psychiatric Social Work: 1 Ms. Divya Ravindran Kerala Ms. Manjula TV Karnataka Ms. Merlyn M Peter Karnataka Speech Pathology & Audiology: 1 Maj. Pushplata Rawat New Delhi Mr. CG Praveen Kumar Karnataka Ms. Seema Sadanand Parab Maharashtra Ms. Shabana Abusufian Biswas Maharashtra III. DM (Neurology): 3 Ms. Shamal Shantaram Gawade Maharashtra Dr. Menka Jha Odisa Sri. Sunil Rangrao Dinde Maharashtra Dr. Nitish Kumar Bihar Ms. Susanna Nirmala Samuel Karnataka Dr. Ravindranadh Chowdary M Andhra Pradesh Ms. Vaishali Nakul Patil Maharashtra
82 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 Annual Report 2014-15
III. Post-Basic Diploma (Neuroscience Nursing): 3 F. Other Training Mr. Lijo Joy Kerala Lt. Col. Nalini G Tamil Nadu I. Courses offered at NIMHANS Mrs. Shailaja K Karnataka Number of Candidates Sl.No. Name of the Course Ph.D Candidates under External Fellowships as on 31.03.2015 Passed Ongoing DST-In- Department CSIR UGC ICMR DST OTHERS TOTAL 1. Neuroanaesthesia spire B.Sc. (Anaesthesia Technology) 3 (I year 12 Basic Sciences Division Internship) Biophysics 1 - - - 1 4 6 2. Neuro Imaging & Interventional Biostatistics - - 1 - - 2 3 Radiology Human B.Sc. Radiography 8 26 - 3 - - 1 - 4 Genetics Radiography Trainee course 8 12 Neuro- 3 2 - 1 - 3 9 3. Neurology chemistry Diploma (Diploma in clinical Neu- - 11 Neuromi- 2 6 - - - - 8 rophysiology Technology (DCNT) crobiology 4. Nursing Neurophysi- 3 6 1 - - 4 14 Diploma in Psychiatric Nursing 17 8 ology (DPN) Neurovirol- 1 - - - - 2 3 Diploma in Neuro Nursing (DNN) 3 2 ogy 5. Psychiatry Psychophar- - - 1 - 1 1 3 Diploma (Psychiatry) 2014-16 - 9 macology Behavioral Sciences Division Diploma (Psychiatry) 2013-15 Completing - in April 2015 Clinical Psy- - 6 6 - - 4 16 chology A total of 1,199 students from outside institutes attended various Psychiatric - 8 2 - - 8 18 Social Work training programmes (of periods ranging from 15 days to 30 days), to Psychiatry 1 - 1 - - 16 18 gain clinical experience at the Department of Nursing, NIMHANS. Neuro Sciences Division Neurology - - - - - 1 1 Mr. Rozuddin Yousufi, Nursing Director, Kabul Mental Health Clinical Hospital, Afghanistan, visited the Department of Nursing, Neuro- - - 24 - - - 24 NIMHANS (17-21 November 2014). The Department of Nursing sciences provided detailed orientation on academic programmes of the Neuro- 1 1 - - - 2 4 Institute and various activities of the nursing team in different sections pathology of Psychiatry and the Neuro Centre. TOTAL 12 32 36 01 03 47 131
A total of 23 nursing personnel attended the training programme on HIV/AIDS under GFATM project during the period April 2010 2011 2012 2013 2014 Total 2014-March 2015 at the NIMHANS College of Nursing. CSIR 03 03 03 03 - 12 UGC - 04 07 08 13 32 Training and capacity building ICMR 05 07 09 09 06 36 DST - - 01 - - 01 Various post-graduate trainees from the Departments of Psychiatry, DST-Inspire 01 01 01 - 03 Clinical Psychology, Psychiatric Social Work, Nursing of the Institute OTHERS 06 08 10 12 10 46 received hands-on training in the management of persons with Total 14 23 31 33 29 130 addiction.
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Virtual Learning Centre: Centre for Addiction Medicine has participate in this weekly video conference based sessions. In the year initiated the weekly “Online” multipoint videoconference capacity under review, 520 participated in this weekly programme and 300 building training from April 2014. received certification for completion of their module. Please visit vlc. nimhans.ac.in for details. Extra-mural training (ONLINE): Virtual Knowledge Network facilitates Innovative and free interactive online skill building Topics (Virtual) Month activity in the area of Mental Health. The treatment gap in mental Alcohol Addiction Assessment and Burden March– April 2014 health is huge in our country. Virtual Knolwedge Network (VKN) Opioid Use Disorder and Management July -August 2014 NIMHANS is running weekly online NIMHANS ECHO sessions Addiction and Co morbidity September 2014 to bridge the gap. The Project ECHO, US is the intellectual partner Cannabis Use Disorder October 2014 of this initiative. The heart of this NIMHANS ECHO model is its Psychosocial Assessment and Intervention November, 2014 hub-and-spoke knowledge-sharing networks, led by expert teams Addiction Pharmacology Jan - Feb 2015 who use multi-point videoconferencing to conduct virtual clinics Helping People : Quit Tobacco March - April 2015 with community health care providers (doctors and others). In this way, doctors, nurses, and other clinicians learn to provide excellent II. Students from other Institutions coming to specialty care to patients in their own communities. NIMHANS for training
The ongoing weekly VKN NIMHANS ECHO tele-health session, No. of Can- Sl.No. Stream Total a collaboration with Project ECHO USA, consists of components of didates both case based learning i.e. case presentation and didactic sessions A. INTERNATIONAL by experts. The aim of the programme is to develop a learning Clinical Psychologist 1 1 loop and a knowledge-sharing network which will create in-depth B. NATIONAL knowledge, skills and self-efficacy among health care practitioners. 01. Biophysics 7 This guided practice helps in the process of reducing disparity BTech (Biotechnology) 2 in the standard of treatment in the country. The partner health MSc (Biochemical Technology) 1 professionals also present cases for discussions and learning. This MSc (Physics) 2 live (Synchronous) session are integrated with an e-learning module MSc (Biochemistry) 1 certification for participants. Integrated MSc (Biological Sciences) 1 02. Biostatistics 7 MSc (Biostatistics) 7 03. Child & Adolescent Psychiatry 185 MD (Psychiatry) 101 DNB (Psychiatry) 11 DPM (Psychiatry) 13 MD (Psychiatry) (Homeopathy) 7 PDF (Child & Adolescent Psychiatry) 2 MD (Pediatrics) 32 DCh 5 DNB (Pediatrics) 4 DM (Neurology) 2 MSc (Psychosocial Rehabilitation) 8 04. Clinical Psychology 280 MD 98 DPM 1 DM (Neurology) 1 Reach of VKN NIMHANS. Inset: VKN session in progress DM 1 MPhil (Clinical Psychology) 27 MTech (Integrated M.Tech Program in 6 At this point, there are 700 health care professionals including medical Cognitive Neuroscience) colleges partnering in this free of cost knowledge sharing platform. PhD 5 Approximately 15 classrooms and 50 individual health professionals P3 REACH 3
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No. of Can- No. of Can- Sl.No. Stream Total Sl.No. Stream Total didates didates Certificate Course in Child Thera- 3 12. Neuromicrobiology 17 py, Adolescent Therapy and Family MSc (Microbiology) 14 Therapy BSc( Biotechnology) 2 MPhil (Psychotherapy) 4 MTech (Biotechnology and 1 Psychologists 18 Biochemical Engg.) PG 22 13. Neuropathology 496 BE/ B.Tech 1 DM (Neurology ) 66 Clinical Psychologist 1 MCh (Neurosurgery) 19 Certificate Course in CBT 8 MD (Pathology) 139 Asst. Professor in Psychiatry 21 Consultants (Pathology) 3 Undergraduate students 2 DM (Neuroradiology) 2 B.A & M.A Clinical Psychology 41 MD (Dental) 03 Internal (M.Sc Nursing/ DPM/MD/ MBBS (Medical Officers) 56 DM/ M.Ch) M.Tech (Biotechnology) 03 M.Sc (Psychiatric Nursing (II yr) 8 MSc (Microbiology) 1 DM (Child & Adolescent Psychiatry) 3 MSc (MLT) 1 PDF (Child & Adolescent Psychiatry) 2 BSc (Nursing) 69 MPhil (Neuroscience) 3 BSc (Neuroanesthesia) 03 PDF (Neurological Rehabilitation) 1 Technicians 81 05. Epidemiology 9 Nursing staff 50 MD (Community Medicine) 9 Neuropathology Museum 642 06. Human Genetics 43 MD / MS 240 BSc 4 MSc (Nursing) 23 MSc 4 MSc (Speech Pathology) 40 BE/B.Tech 11 BSc (Speech Pathology) 120 BE 24 BSc (Nursing) 29 07. Neuroanaesthesia 141 Diploma (Nursing) 73 MD / MS 137 B.P.T. 20 BSc (Anaesthesia technology) 4 C.C.T. (Cardiac Care Technicians) 20 08. Neurochemistry 35 BSc (O.T.Technicians) 11 MD/MS 1 Renal Dialysis Technician 18 Research Scholar (SRF) 1 Diploma (OT) 5 Research Scholar (JRF) 1 Diploma (X-ray Technician) 6 MSc 2 Diploma (Radiotherapy Technician) 6 BE 26 Diploma (Respiratory Technician) 18 B.Tech 1 Diploma (Medical Laboratory Techni- 12 BSc 3 cian) 09. Neuro Imaging & Interventional 120 Pre-University College 1 Radiology 14. Neurophysiology 45 MD/ DNB/ Diploma / MCh / DM 120 BS-MS 1 (Neurology ) MSc (Life Sciences) 1 10. Neurological Rehabilitation 81 MSc (Biotechnology) 1 MD / MS 3 M.Tech (Biotechnology ) 2 DM 2 BE (Biotechnology) 4 MSc / MPT (Physiotherapy) 27 PhD (Biotechnology) 1 BSc / BPT/ BOT (Physiotherapy) 49 PhD 4 11. Neurology 368 B.Tech (Biotechnology) 6 MD 352 MS (Neurosciences) 7 MSc 16 MBBS 4
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No. of Can- No. of Can- Sl.No. Stream Total Sl.No. Stream Total didates didates MD (Physiology) 7 19. Psychiatric Rehabilitation 16 BNYS (Internship) 3 Caregivers training programme (Rec- 16 MD (Psychiatry) 1 ognized by RCI) BE (Bio Medical Engineering) 3 20. Psychiatric Social Work 1149 15. Neurosurgery 235 MSW 1149 MCh 28 21. Psychopharmacology 18 DNB (Neurosurgery) 5 MBBS 1 MS (General Surgery, ENT and DNB, 202 M.Pharm 4 Facio Maxillary etc.,) M.Tech 4 16. Neurovirology 63 B.Tech 7 MD 55 MSc 2 MSc (Microbiology) 4 22. Speech Pathology & Audiology 152 MPhil 4 DM (Radiotherapy) 1 17. Nursing 1199 MS (ENT) 36 MSc (Nursing) 619 MSc (Speech & Hearing) 1 Basic BSc (Nursing) 37 BSc (Nursing) 396 BSc (Speech & Hearing) 101 GNM 99 DM/PDF-CAP 4 DPN 7 Bio-Medical & others 9 Post Basic Diploma (Nursing) 41 18. Psychiatry 1257 MD / MS (Psychiatry, Ayurveda, Com- 338 Number of trainees who underwent training at munity Medicine) NIMHANS: MSc (Nursing) 519 BSc (Nursing) 379 A total of 3190 students from various government/private institutions Diploma (Nursing) 20 across the country visited and underwent training at NIMHANS PhD (Nursing) 1 during the period 1 April 2014-31 March 2015.
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19th Convocation Awardees
Dr. Padwal Amit Dattatray Dr. Arun Babu R Dr. Manjula A. Silver Jubilee Award for the best Silver Jubilee Award outgoing student in M.Ch. Neurosurgery for the best outgoing student in MD 2014 Psychiatry – 2014
Dr. Lavanya P. Sharma Mr. Mohd. Afsar Dr. D.L.N. Murthy Rao Dr. M.V. Govindaswamy Memorial Prize for the best Memorial Prize for scoring the outgoing student in Diploma in highest marks in M.Phil. Clinical Psychiatry - 2014 Psychology - 2014
Ms. Chandni A. Chandran Dr. M.V. Govindaswamy Memorial Prize for scoring the highest marks in M.Phil. Psychiatric Social Work – 2014
Ms. Merlin P.B. Mr. Yuvraj Joshi Dr. R.N. Moorthy Award for Dr. R.N. Moorthy Award scoring the highest marks in M.Phil. for scoring the highest marks in M.Phil. Neurophysiology - 2014 Biophysics - 2014 Ms. Diksy Jose Dr. Jaychandran R. Dr. R.N. Moorthy Award for Dr. Anisya Vasanth Memorial Award scoring the highest marks in M.Sc. for the Best Post-Graduate Resident in Psychiatric Nursing - 2014 Neurology – 2014
Institute Day 2015 Awardees
Ms. Dhanisha V. Best Out-Going Student in Diploma in Clinical Neurophysiology Technology (DCNT) Course 2014
Maj. Pushplata Rawat Lt. Col. Nalini G. Dr M. V. Govindaswamy Infosys Foundation Award & Dr .L.N. Murthy Rao Memorial for Excellence (In Cash) and Prize and Infosys Foundation Award Mukund Memorial Award (In Cash) for Excellence (In Cash) for Securing the for Securing Distinction In Post-Basic Highest Marks Diploma in Neuro Science Nursing in Post-Basic Diploma in Psychiatric/ Examination - April 2014 Mental Health Nursing Examination – April 2014 Conference/Symposia/ Workshops
I. SCIENTIFIC PROGRAMMES ORGANISED AT and Interventional Radiology, conducted Indo-German NIMHANS Workshop on Medical Imaging, 4 December 2014. 120 members participated. A. International
Dr. Sanjeev Jain, Professor of Psychiatry, conducted International China-India Mental Health Alliance Meeting, 24-26 July 2014. 30 members participated.
Indo-German Workshop on Medical Imaging
Dr. GS Umamaheswara Rao, Sr. Professor, Dr. B Indira Devi, Professor and Head of Neurosurgery, conducted Osaka- Public Seminar on Mental Health in China and India NIMHANS Scientific Programme, 7 January 2015. 80 members participated.
Dr. GS Umamaheswara Rao, Sr. Professor of Neuroanaesthesia, Dr. K John Vijay Sagar, Associate Professor of Child and conducted NIMHANS-Maastricht Joint Workshop on Adolescent Psychiatry, conducted (i) interdepartmental workshop Neuropsychiatry, 12-14 March 2015. 80 members participated. on Ethics in Research, 5 August 2014. 45 members participated (ii) interdepartmental Indo-US Fogarty Annual Symposium, 12- 15 January 2015. 100 members participated (iii) interdepartmental workshop on Research Skills and Ethics- Indo-US Fogarty Annual Symposium, 15 January 2015. 50 members participated.
Dr. MM Srinivas Bharath, Additional Professor of Neurochemistry, conducted 2014 Next Gen Genomics & Bioinformatics Technologies (NGBT) conference, hosted by: SciGenom Research Foundation (SGRF), NIMHANS and Institute of Bioinformatics (IOB) Conference chair/Organizing Secretary: Dr. Sekar Seshagiri, Principal Scientist, Genentech Inc., South San Francisco, CA, USA, 17-19 November 2014. 200 members participated.
NIMHANS-Maastricht Joint Workshop on Neuropsychiatry Dr. Madhusudana SN, Professor of Neurovirology, Dr. Reeta Mani, Assistant Professor of Neurovirology, Dr. Ashwini MA, Sr. Resident of Neurovirology, conducted WHO sponsored training in Rabies Dr. GS Umamaheswara Rao, Sr. Professor of Neuroanaesthesia, Diagnostics for Virologists from Bangladesh and Sri Lanka, 10-22 Dr. Arun Kumar Gupta, Professor and Head of Neuro Imaging November 2014. 6 members participated.
National Institute of Mental Health and Neuro Sciences 91| Annual Report 2014-15
B. National Dr. Shekhar Seshadri, Professor of Child & Adolescent Psychiatry, conducted (i) Training for ICPS Counsellors, Raipur, Chattisgarh, Biophysics 29-31 May 2014. 60 members Participated (ii) Workshop on Child Development, Bangalore, 7-9 August 2014. 25 members participated Dr. B Padmanabhan, Additional Professor, Dr. P Marimuthu, Additional Professor of Biostatistics, Dr. Kshitish Acharya, IBAB, Bangalore, Dr. Keshava Prasad, IOB, Bangalore, conducted workshop Clinical Psychology on Bioinformatics and its Applications to Neural Disorders, 5-8 August 2014. 60 members participated. Dr. Mahendra P Sharma, Professor and Head, Dr. Paulomi M Sudhir, Additional Professor, conducted workshop on De-stressing Mindfully: Dr. B Padmanabhan, Additional Professor, conducted 10th Managing Work Stress, 23 August 2014. 30 members participated. National Program Advisory Committee (PAC) BBMM Meeting, DST, Government of India, 2-3 July 2014. 50 members Dr. Mahendra P Sharma, Professor and Head and PhD Scholars, participated. conducted workshop titled De-stressing Mindfully: Managing Work Stress for Air Force personnel, 26 September 2014. 11 members participated. Biostatistics Dr. Mahendra P Sharma, Professor and Head, Dr. Paulomi M Sudhir, Dr. K Thennarasu, Professor, Dr. Mariamma Philip, Assistant Additional Professor, Dr. M Manjula, Associate Professor, conducted Professor, conducted national workshop on Statistical Methods in workshop on Mindfulness–Based Cognitive Behavioral Interventions: Medical Research and Introduction to SPSS for medical researchers, Applications in Clinical and Nonclinical Settings, 21-22 November 10-12 July 2015. 60 members participated. 2014. 51 members participated.
Dr. P Marimuthu, Additional Professor, Dr. Mariamma Philip, Dr. Ahalya Raguram, Professor, Dr. Poornima Bhola, Associate Assistant Professor, conducted national refresher course in Statistical Professor, conducted workshop on Psychodynamic Concepts: Methods for Behavioral Research, 23-25 September 2014. 43 Bridging the Gap between Theory and Practice, 13 October 2014. 49 members participated. members participated.
Dr. B Binukumar, Assistant Professor, Dr. DK Subbakrishna, Dr. Uma Hirisave, Professor, conducted (i) National group interactive Professor and Head, conducted national workshop on Statistical Data session on Coping with Stress, 15 May 2014. 9 members participated Analysis Using Stata in Health Research, 18-20 March 2015. 12 (ii) workshop on Assessment of Intellectual Functions, 11 September members participated. 2014. 14 members participated (iii) National workshop on assessment of readiness skills and SLD Level 1, 16 September 2014 (iv) National workshop on Intervention of Learning Difficulties- group session, 20 Child & Adolescent Psychiatry September 2014. 14 members participated.
Dr. Satish Girimaji, Professor and Head, Dr. N Shivashankar, Dr. Anisha Shah, Professor, conducted (i) workshop on Orientation Professor and Head of Speech Pathology and Audiology, Seva-in- to Psychotherapy: Constructivist, Emotion Focused and Action, SNAC Karnataka of National Trust and National Health Psychodynamic Approaches, 17 and 19-21 January 2015 (12 hours). Mission Karnataka, conducted interdepartmental and inter- 20 members participated (ii) National workshop on Emotion Focused institutional workshop on Early Intervention (EI) & Rehabilitation Psychotherapy, 24, 29 November 1, 6, 8 December, 2014 (10 hours). for Children with Intellectual & Developmental Disabilities, 23-24 22 members participated. January 2015. 140 members participated Dr. LN Suman, Professor, Dr. Veena AS, Assistant Professor along Dr. Satish Girimaji, Professor and Head, Dr. Uma Hirisave, Professor with Dr. Kavita Jangam, Assistant Professor of Psychiatric Social of Clinical Psychology, Dr. Shoba Srinath, Professor, Dr. Shekhar Work, conducted (i) ACT: Awareness for Counselors about Trauma- Seshadri, Professor, Dr. K John Vijay Sagar, Associate Professor, A workshop for Counselors on Psychological Trauma, 3 September conducted national training of psychologists under Rashtriya Bala 2014. 28 members participated (ii) CARE: Crisis Alleviation and Swasthya Karyakram (RBSK), 1-30 September 2014. 14 members Recovery from Emergencies- A workshop for Counselors on Crisis participated. Counseling, 12 November 2014. 26 members participated (iii)
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SCARS: Securing Courage and Resilience for the Sheltered-A Dr. M Manjula, Associate Professor, Dr. Paulomi Sudhir, Additional Trauma-Informed Care Workshop for Counselors in Shelter Homes, Professor, Dr. Mahendra P Sharma, Professor and Head, conducted 7 January 2015. 12 members participated (iv) STAR: Secondary National workshop on (i) Cognitive Behavior Therapy in Sexual Trauma Alleviation and Recovery - A workshop on Counselor Dysfunctions, 25-26 July 2014. 38 members participated (ii) Cognitive Wellness, 11 March 2015. 11 members participated. Behavior Therapy: Principles and Applications, 30-31 October 2014. 63 members participated. Dr. Seema Mehrotra, Additional Professor, conducted (i) Regional trainers workshop on Smart Riders (Road safety), 20 June 2014. 13 Dr. M Manjula, Associate Professor, Dr. Hesi Herbert, Clinical members participated (ii) Regional workshop on Youth Pro, (a) 27 Psychologist, Ms. Seema Nambiar, PhD Scholar, conducted workshop June 2014. 46 members participated (b) 8 August 2014. 28 members on Managing Academic Stress, 20 September 2014. 23 members participated (c) 12 August 2014. 21 members participated (d) 9 participated. March 2014. 35 members participated (iii) Regional workshop on setting up Mental Health Promotive Services in University Campus, Dr. Devvarta Kumar, Associate Professor, Dr. Poornima Bhola, 23 December 2014. 20 members participated (iv) Regional workshop Associate Professor, conducted national workshop on Psychological on Applying Positive Psychology in Daily Life (APP), 7 February Interventions in Schizophrenia: Social Skills Training and 2014. 28 members participated Metacognitive Therapy in Recovery-Oriented Practice, 21 February 2015. 52 members participated. Dr. Seema Mehrotra, Additional Professor, Dr. Paulomi Sudhir, Additional Professor, Dr. Veena AS, Assistant Professor, conducted Dr. Devvarta Kumar, Associate Professor, Dr. M Thomas Kishore, workshop on Think Tank Meet (for administrative heads of institutes Associate Professor, conducted workshop on Comprehensive System of higher education on youth mental health promotion), 30 January of Rorschach, 16-17 January 2015. 20 members participated. 2014. 35 members participated. Dr. Poornima Bhola, Associate Professor, Dr. Paulomi M Sudhir, Dr. Paulomi M. Sudhir, Additional Professor, Dr. Seema Mehrotra, Additional Professor, conducted national workshop on Workplace Additional Professor, conducted workshop on Work Stress and Mental Health: Creating Awareness, Building Skills, 19-20 February Mental Health, (a) 23 December 2014. 7 members participated (b) 5 2015. 22 members participated. March 2015. 5 members participated. Dr. Poornima Bhola, Associate Professor, Dr. Rathna Isaac, conducted Dr. Paulomi M Sudhir, Additional Professor, conducted national national workshop on Personal Values in the Therapy Room, 17 workshop on Cognitive Behavior Therapy: For Obsessive Compulsive January, 2015. 18 members participated. Disorder, 23-24 January 2015. 49 members participated Dr. Poornima Bhola, Associate Professor, conducted national Dr. Paulomi M Sudhir, Additional Professor along with PhD Scholars, workshop on (i) Self-Injurious Behaviors: Awareness, Understanding conducted workshop on Understanding and Managing Anxiety in and Assessment, 6 September 2014. 22 members participated (ii) Social Interactions, 1 May 2014. Mirror, Mirror on the Wall: Becoming a Self-Reflective Practitioner, 22 September 2014. 24 members participated (iii) Ethical Practice Dr. Manoj K Sharma, Associate Professor, conducted workshop on in Psychotherapy, national workshop on Psychotherapy Practice (i) Digital Addiction, 18 October 2014. 30 members participated (ii) in Medical and Psychiatric Social Work Setting, 31 July 2014. 70 Video Game Addiction: Issues and Management, 2 September 2014. members participated. 20 members participated Dr. Roopesh BN, Assistant Professor, conducted workshop on Dr. M Manjula, Associate Professor, conducted workshop on (i) Behavioral Management of ADHD in Children and Adolescents, 21 Maintaining Healthy Relationships, 26 April 2014. 20 members October 2014. participated (ii) Emotion Regulation for Healthy Living, 21 June 2014. 10 members participated. Epidemiology Dr. M Manjula, Associate Professor along with PhD Scholars, conducted workshop on (i) Maintaining Healthy Parent Teenager/ Dr. Gururaj, Professor and Head, Dr. Pradeep BS, Associate Young adult Relationships, 5 July 2014. 10 members participated. Professor, conducted symposium on Youth Mental Health in India: (ii) Maintaining Healthy Relationship: A Workshop for Youth, 6 A Public Health Perspective, 3 December 2014, 210 members December 2014. 8 members participated. participated.
National Institute of Mental Health and Neuro Sciences 93| Annual Report 2014-15
Suicide Prevention, 10 October 2014. 18 members participated.
Department of Mental Health Education and Centre for Public Health NIMHANS conducted an Interdepartmental workshop on Qualitative Research Methods for Kolar Pilot Study, 3-5 February 2015. 12 members participated
Department of Mental Health Education, NCWB, conducted half-day workshop on Building Resilience in Children, 21 February 2015. 22 members participated.
Dr. Jayashree Ramakrishna, Professor and Head along with Dr. Inauguration of symposium on Youth Mental Health in India: A Public Health Vivek Gupta, Assistant Professor of Epidemiology, conducted Perspective, interdepartmental workshop on introduction to Open Data Kit (ODK), Dr. Girish N, Additional Professor, Dr. Senthil Amudhan, Assistant 12, 13 and 15 January 2015. 12 members participated Professor, conducted workshop on Research Methodology-2014, 10-12 December 2014. 49 members (including two international candidates) Department of Mental Health Education, NIMHANS Centre participated. for Public Health, Karnataka Janaarogya Chaluvali, conducted interdepartmental half-day symposium and screening of the movie The Fatal Error, 17 March 2015. 23 members participated. Mental Health Education Department of Mental Health Education conducted (i) two-day training Dr. Jayashree Ramakrishna, Professor and Head along with Prof. session on Use of Radio and Video in Imparting Health Education, Mitchell Weiss, Swiss Tropical and PH Institute and Dr. Girish, M.Sc. Nursing students, Department of Nursing, NIMHANS (ii) half- Additional Professor of Epidemiology, conducted national workshop day training on Introduction to Mental and Neurological Disorders for on Integrating Qualitative & Quantitative Research Methods, 35 Lady Health Visitors from Victoria Hospital, 3 November 2014. Fundamentals and Innovative Strategies, 2-4 September 2014. 49 members participated. Neuroanaesthesia Department of Mental Health Education and Swiss Tropical and Public Health Institute, Basel, Switzerland in association with swissnex, Dr. GS Umamaheswara Rao, Sr. Professor, Dr. Madhusudhan Reddy, conducted symposium on Films for Health, 15 November 2014. 30 Professor and Head, Dr. Radhakrishnan, Additional Professor, Dr. members participated. Gopalakrishna KN, Assistant Professor, conducted interdepartmental workshop on Neurocritical Care -Neurovascon 2014, 5 September 2014. 60 members participated.
Dr. Ramesh VJ, Professor, Dr. Sonia B, Assistant Professor, conducted workshop on Cardiac Output Monitoring in Neurocritical Care, 14th Annual Meeting of Cerebrovascular Society of India, 5-7 September 2014. 50 members participated.
Dr. Ramesh VJ, Professor, Dr. Radhakrishnan M, Additional Professor, Dr. Sriganesh K, Associate Professor, conducted CME on Essential Neuroanaesthesia for Occasional Neuroanaesthesiologists, 18 January 2015. 100 members participated.
Symposium on Films for Health
Neurochemistry Department of Mental Health Education, NCWB, Department of Health and Family Welfare, Karnataka Government, conducted Dr. MM Srinivas Bharath, Additional Professor, Dr. N Gayathri, Departmental half-day workshop on Gatekeepers Training in Professor of Neuropathology, Dr. BK Chandra Shekhar Sagar,
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Additional Professor of Neuropathology, conducted Mito Neurology Symposium NIMHANS 2014, 20 July 2014. 45 members participated. Dr. P Satishchandra, Director/Vice Chancellor, Dr. AB Taly, Professor, Dr. PK Pal, Professor, Dr. Sanjib Sinha, Additional Dr. Nandakumar DN, Additional Professor, conducted five workshops Professor, Dr. Netravathi M, Assistant Professor, Dr. Subasree R, as part of Quality Assurance and Continuous Improvement Assistant Professor, Dr. Madhu N, Assistant Professor, conducted TS Programme for technical staff, 15 May-28 November 2014. Srinivasan NIMHANS Knowledge Conclave, 12-13 February 2015. 200 members participated.
Neuro Imaging & Interventional Dr. PK Pal, Professor, Dr. Sanjib Sinha, Additional Professor, Dr. Radiology Girish Baburao Kulkarni, Associate Professor, Dr. Ravi Yadav, Associate Professor, Dr. Netravathi M, Assistant Professor, Dr. Dr. AK Gupta, Professor and Head, Dr. Chandrajit Prasad, Assistant Subasree R, Assistant Professor, conducted IAN Summer Course, Professor, Dr. Rose Dawn Bharath, Associate Professor, Dr. Hima 10-13 April 2014. 250 members participated. Pendharkar, Associate Professor, Dr. Arvinda HR, Associate Professor, Dr. Jitender Saini, Assistant Professor, conducted Dr. Mahadevan Dr. Girish Baburao Kulkarni, Associate Professor, conducted Pillai Memorial CME on Update in Neuroimaging 2014, 29 June interdepartmental CME on Autonomic Dysfunction, 12-13 February 2014. 150 members participated. 2015. 160 members participated.
Neuromicrobiology
Dr. HB Veenakumari, Additional Professor, Dr. S Nagarathna, Additional Professor, in association with the Dept. of Nursing conducted Global Hand Washing Day, 15 October 2014. 150 members participated.
Neuropathology
Dr. Sundar Periyavan, Professor, conducted (i) National Bombay Dr. Mahadevan Pillai Memorial CME on Update in Neuroimaging 2014 Blood Group Donor’s Meet, Transfusion Medicine Centre, 16 June 2014. 20 members participated (ii) National Workshop for Blood Dr. AK Gupta, Professor and Head, Dr. Chandrajit Prasad, Assistant Bank Officers for Consensus on Blood Donor Criteria, 14-19 July Professor, Dr. Rose Dawn Bharath, Associate Professor, Dr. Hima 2014. 10 members participated. Pendharkar, Associate Professor, Dr. Arvinda HR, Associate Professor, Dr. Jitender Saini, Assistant Professor, Dr. Maya Bhat, Assistant Professor, conducted Dr. Mahadevan Pillai Memorial CME on Functional MRI: Seeking New Frontiers, 23 November 2014. 150 members participated.
Dr. Rose Dawn Bharath, Associate Professor, along with Dr. Umamaheshwara Rao, Sr. Professor of Anaesthesia, Dr. Ramesh VJ, Professor of Neuroanaesthesia, Dr Srivas Chennu, University of Cambridge, conducted interdepartmental workshop on Translational Neuroscience in Altered States of Consciousness: Linking Neuroimaging of Brain Injury and Anaesthesia for Improved Diagnosis and Prognosis, 7-9 March 2015. 20 members National Bombay Blood Group Donor’s Meet participated.
National Institute of Mental Health and Neuro Sciences 95| Annual Report 2014-15
Dr. SK Shankar, Emeritus Professor, Dr. Anita Mahadevan, Additional Dr. Satyaprabha, Additional Professor, Dr. Laxmi T Rao, Associate Professor, Mr. Suresh Parmar, Human Brain Bank, conducted World Professor, Mr. Suresh Parmar, Human Brain Bank, conducted national Brain Day Celebrations- Our Brain, Our Future, 22 July 2014. 200 workshop on Indian Academy of Neurosciences - Popularization of Schoolchildren and teachers participated. Neuroscience- NIMHANS, 3 November 2014. 250 schoolchildren participated.
Dr. Laxmi T Rao, Associate Professor, conducted seminar by APPI- Bangalore chapter (i) 19 April 2014. 60 members participated (ii) 22 August 2014. 75 members participated.
Dr. Phalguni Anand Alladi, Senior Scientific Officer, conducted departmental symposium on Immunochemistry and Chromatin Immunoprecipitation Technology, 4 December 2014. 150 members participated. International Symposium on Translational Neuroscience and XXXII Annual Conference of Indian Academy of Neurosciences
Neurosurgery Dr. Gayathri N, Professor, Dr. BK Chandrasekhar Sagar, Additional Professor, Dr. MM Srinivas Bharath, Additional Professor Dr. B Indira Devi, Professor and Head, Dr. Dhananjaya I Bhat, of Neurochemistry, conducted third hands-on workshop on Additional Professor, conducted 7th National NSI Teaching Course Neurochemistry and Electron Microscopy, 14-19 July 2014. 19 and 1st NSI Foundation Course, 31 January-1 February 2015. 110 members participated. residents from department and Faculty various institutes in India participated.
Neurophysiology Dr. Paritosh Pandey, Additional Professor, Dr. Dwarakanath Srinivas, Additional Professor, Dr. S Sampath, Professor, conducted 14th Dr. TR Raju, Sr. Professor and Head, Dr. BS Shankaranarayana Annual National Conference of Cerebrovascular society of India, 5-7 Rao, Additional Professor, Dr. Bindu M Kutty, Professor, Dr. TN September 2014. 400 members participated. Sathyaprabha, Additional Professor, Dr. Laxmi T Rao, Associate Professor, Dr. Phalguni Anand Alladi, Senior Scientific Officer, conducted International Symposium on Translational Neuroscience and XXXII Annual Conference of Indian Academy of Neurosciences. 1-3 November 2014. 600 members participated.
7th National NSI Teaching Course and 1st NSI Foundation Course International Symposium on Translational Neuroscience and XXXII Annual Conference of Indian Academy of Neurosciences Dr. Dwarakanath Srinivas, Additional Professor, Dr. A Arivazhagan, Associate Professor, Dr. Malla Bhaskara Rao, Professor, conducted Dr. TN Sathyaprabha, Additional Professor, conducted (i) national 2nd National Bi-Annual CME of Indian Society of Stereotactic and workshop on Autonomic Function, APPICON 2014, 1-3 November Functional Neurosurgery, 27-28 September 2014. 150 members 2014. 95 members participated participated.
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Neurovirology Dr. Sailaxmi Gandhi, Assistant Professor, Dr. K Lalitha, Professor and Head, Dr. Ramachandra, Additional Professor, Mrs. Mythili Dr. V Ravi, Professor and Head, Dr. Anita Desai, Additional D, Clinical Instructor, conducted departmental workshop on Professor, Dr. Reeta Mani, Assistant Professor, Dr. Vijayalakshmi R, Innovative Teaching Techniques in Psychiatric Nursing (funded by PDF, conducted national workshop and hands-on training in Good Dr. Ramachandra N. Moorthy Foundation for Mental Health & Laboratory Practices, Reporting and Quality Assurance in JE Testing, Neurological Sciences), 26 November 2014. 102 members participated. 2-6 June 2014. 15 members participated. Dr. Sailaxmi Gandhi, Assistant Professor, Dr. K Lalitha, Professor Dr. V Ravi, Professor and Head, Dr. Anita Desai, Additional and Head, Ms. Achla Dagdu Gaikwad, PhD Scholar, conducted Professor, Dr. Reeta Mani, Vijayalakshmi R, conducted national interdepartmental workshop on Childhood Behavioral Disorders workshop and hands-on training in Diagnosis and Detection of Non- & Its Management: A Multidisciplinary Approach (funded by AES Pathogens, 2-6 September 2014. 10 members participated. Dr. Ramachandra N Moorthy Foundation for Mental Health & Neurological Sciences), 22 January 2015. 100 members participated. Dr. V Ravi, Professor and Head, Dr. Manjunatha MV, Sr. Scientific Officer, conducted interdepartmental hands-on workshop on Flow Dr. Sailalxmi Gandhi, Assistant Professor, Mrs. Kochuthresia PK, Cytometry Applications, 16-18 June 2014. 10 members participated. Nursing Tutor, conducted departmental 12 focus-group discussions on Suicide Prevention with family members of persons with mental Dr. Anita Desai, Additional Professor, conducted two EQAS illness, 22 April 2014. 108 members participated. workshops, 2 July 2014 and 3 January 2015. 10 Technical Officers from 10 State Reference Laboratories participated. Dr. Sailaxmi Gandhi, Assistant Professor, conducted interdepartmental first meeting of the group to draft a management protocol for identifying and managing maternal mental health problems in an Nursing urban Primary Health Care setup, 30 July 2014.
Dr. Ramachandra, Additional Professor, conducted (i) departmental Dr. Prasanthi Nattala, Assistant Professor, Dr. K Lalitha, Professor workshop on Evidence-based Practice in Nursing, 12 January 2015. 36 and Head, Dr. Ramachandra, Additional Professor, Dr. Sailaxmi members participated (ii) interdepartmental World Brain Day 2014, Gandhi, Assistant Professor, conducted interdepartmental seminar 22 July 2014 (iii) departmental workshop on Successful Mentoring in on Intervening with Tobacco Users: Role of Nursing Professionals, 8 Nursing, 19 July 2014. 36 members participated. October 2014. 60 members participated.
Dr. Sailaxmi Gandhi, Assistant Professor, Dr. K Lalitha, Professor and Dr. Prasanthi Nattala, Assistant Professor, Dr. Pratima Murthy, Head, Dr. Ramachandra, Additional Professor, Mrs. Kochuthresia Professor of Psychiatry, Dr. Lalitha K, Professor and Head, Dr. PK, Nursing Tutor, conducted World Breast Feeding Celebration Ramachandra, Additional Professor, conducted regional workshop commemorative event, 7 August 2014. 162 members participated. on Relapse Prevention in Alcohol Dependence, 28 January 2015. 30 members participated. Dr. Sailaxmi Gandhi, Assistant Professor, Mrs. Glory Joseph, Nursing Tutor, Ms. H Premalatha Chinnayya, Ward Supervisor, Ms. Lalitha, Dr. G Radhakrishnan, Assistant Professor, conducted interdepartmental Ward Supervisor, Mrs. Rathnamma L, Staff Nurse in collaboration workshop on Community Mental Health Nursing (funded by with Dr. SK. Chaturvedi, Professor of Psychiatry, Dr. Jagadisha Dr. Ramachandra N Moorthy Foundation for Mental Health & T, Additional Professor of Psychiatry, Dr. Sivakumar T, Assistant Neurological Sciences), 31 March 2015. 58 members participated. Professor of Psychiatry, Dr. Geetha Desai, Associate Professor of Psychiatry, Dr. Poornima Bhola, Associate Professor of Clinical Psychology, Dr. Nirmala BP, Associate Professor, Dr. Naveen Kumar Psychiatry C, Assistant Professor of Psychiatry, Dr. Devartta K, Associate Professor of Clinical Psychology, conducted 11 workshops for patients Dr. Mathew Varghese, Professor and Head, Dr. Srikala Bharath, and their family members on Domestic Skills For the People, By the Professor, Dr. Sivakumar PT, Additional Professor, Dr. Preeti Sinha, People, Of the People (funded by Dr. Ramachandra N. Moorthy Assistant Professor, Dr. Santosh L, Associate Professor, conducted Foundation for Mental Health & Neurological Sciences), 9 October Indian Association for Geriatric Mental Health Mid-Term CME 2014- 25 March 2015. 524 members participated. 2014, 17-18 May 2014. 120 members participated.
National Institute of Mental Health and Neuro Sciences 97| Annual Report 2014-15
Consultant, PSW, conducted five workshops on Gate Keeper Training for Suicide Prevention, NIMHANS Centre for Well Being, BTM Layout- 17 May 2014, 15 members, (b) 06 August 2014. 19 members participated (c) 10 September 2014. 19 members participated (d) 8 October 2014. 15 members participated (c) 28 February 2014. 18 members participated.
Dr. Pratima Murthy, Professor, along with the Centre for Public Health conducted (i) Interdepartmental Field testing of training manuals for addressing risk factors for NCDs (a) for counselors, 14- 17 May 2014. 30 members participated (b) for medical officers, 15 July 2014. 40 members participated. Indian Association for Geriatric Mental Health Mid-Term CME 2014
Dr. G Venkatasubramanian, Additional Professor, Dr. K Dr. YC Janardhan Reddy, Professor, Dr. Muralidharan K, Associate Muralidharan, Associate Professor, conducted workshop on Eye Professor, conducted (i) 5th Annual Conference of the Society for Movement Research in Cognitive Neuroscience, 14-15 March 2015. Bipolar Disorders India (SBDI), 14 December 2014. 200 members 35 members participated. participated (ii) departmental workshop on Current Trends in the Management of Bipolar Disorders, 14 December 2014. 200 members Dr. Geetha Desai, Additional Professor, Dr. SK Chaturvedi, Professor, participated. Dr. Seby K, PhD Scholar, Dr. Suresh Yadav, Sr. Resident, Ms. Fatema Khanum, conducted Interdepartmental workshop on assessment & Dr. Santosh K Chaturvedi, Professor, Dr. Prabha S Chandra, Professor, Management of Medically Unexpalined symptoms, 7 February 2015. Dr. Senthil Kumar Reddi, Assistant Professor, Dr. Abhinav Nahar, 30 members participated. PDF, conducted Guest Lecture Series and Workshop by Emeritus Prof Sidney Bloch- Psychotherapy in Oncology, Ethics in Psychiatry Dr. Geetha Desai, Additional Professor, Dr. Preeti Sinha, Assistant and Art of Psychiatry, 8-10 January 2015. 50 members participated. Professor, Dr. Prabhat Chand, Associate Professor, Dr. Pratima Murthy, Professor, conducted Symposium on Psychotherapy Training Dr. SK.Chaturvedi, Professor, Dr. Prabha S Chandra, Professor, Dr. and Practice, 19 August 2014. 70 members participated. SN Simha, Medical Director, Karunashraya, conducted workshop on Revisiting Doctor Patient Comminications for Clinical Neurosciences Dr. Prabhat Kumar Chand, Associate Professor, conducted (i) one – for Neurology, Neurosurgery and Related Specialities, NIMHANS month Orientation Programme in Substance Use Disorder Treatment, Centre for Well Being (NCWB), 2 January 2015. November 2014. 20 members participated (ii) Training for doctors from south India under National Fund for Control of Drug Abuse, Dr. Srikala Bharath, Professor, conducted departmental workshop on November 2014. 10 members participated Empowering Adolescents Using Life Skills Education, 9-11 October 2014. 28 members participated. Dr. Muralidharan K, Associate Professor, Dr. Venkatasubramanian G, Additional Professor, conducted (i) departmental workshop Dr. Prabha Chandra, Professor, Dr. Suman, Professor of Clinical on Current Trends in the Management of Bipolar Disorders, 23 Psychology, Dr. Suresh B, Additional Professor of Psychiatry, Dr. September 2014. 180 members participated (ii) Eye Movement Vranda MN, Assistant Professor, Dr. Veena, Assistant Professor Research in Cognitive Neuroscience: An Eye Link Workshop, 14-15 of Clinical Psychology, Dr. Sailakshmi, Assistant Professor of March 2015. 36 members participated. Nursing, conducted interdepartmental International Women Day commemorative programme, 500 members participated. Dr. Muralidharan K, Associate Professor, Dr. Venkatasubramanian G, Additional Professor, Dr. Shivarama Varambally, Associate Professor, Dr. Prabha S Chandra, Professor, Ms. Padmavathi, Staff Nurse, conducted departmental Instar Workshop for Psychiatry Post- Junior Consultant of PSW, conducted departmental workshop on graduates, 6 December 2014. 35 members participated. Communication skills for Neurophysicians and Neurosurgeons, NIMHANS Centre for Well Being (NCWB), 2 January 2015 Dr. Senthil Reddi, Assistant Professor, Dr Harish T, Associate Professor, Dr. Santosh K Chaturvedi, Professor, conducted Dr. Prabha S Chandra, Professor, Dr. Senthil Kumar Reddi, interdepartmental workshop on Rediscovering Catatonia, 13 Assistant Professor, Ms. Padmavathy, Staff Nurse, Mr. Ragesh, Junior December 2014. 40 members participated.
98 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Psychiatric Rehabilitation Issues of Women with Intimate Partner Violence/ Domestic Violence, NCWB, 29 October 2014. 60 members participated. Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Khanna M, Assistant Professor of Neurological Rehabilitation, Dr. Jagadisha Dr. N Krishna Reddy, Additional Professor, Dr. N Janardhana, Thirthalli, Additional Professor of Psychiatry, Dr. Anupam Gupta, Assistant Professor, conducted workshop for lay counselors on Child Additional Professor of Neurological Rehabilitation, Dr. Geetha Mental Health, 20 August 2014. 28 members participated. Desai, Associate Professor of Psychiatry, Dr. Devartta K, Associate Professor of Clinical Psychology, Dr. Poornima Bhola, Associate Dr. N Krishna Reddy, Additional Professor, Dr. BP Nirmala, Associate Professor of Neurological Rehabilitation, Dr. Sailaxmi Gandhi, Professor, conducted workshop for lay counselors on Psychiatric Assistant Professor, Dr. Naveen Kumar, Assistant Professor of Rehabilitation Services, 11 June 2014. 35 members participated. Psychiatry, Dr. Taly AB, Professor of Neurology, Dr. SK Chaturvedi, Professor of Psychiatry, conducted International Day for Persons with Dr. N Krishna Reddy, Additional Professor, conducted workshop Disabilities, 30 December 2014. 150 members participated. for lay counselors on Neuro-Surgical Problems, 9 April 2014. 30 members participated. Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Jagadisha Thirthalli, Additional Professor of Psychiatry, Dr. Geetha Desai, Dr. R Dhanasekara Pandian, Additional Professor, Dr. Prasanthi Additional Professor of Psychiatry, Dr. Devvarta Kumar, Associate Nattala, Assistant Professor of Nursing, Dr. Pratima Murthy, Professor of Clinical Psychology, Dr. Poornima Bhola, Associate Professor of Psychiatry, conducted interdepartmental workshop on Professor of Clinical Psychology, Dr. Sailaxmi Gandhi, Assistant Relapse Prevention, 28 January 2015. 35 members participated. Professor, Dr. Naveen Kumar, Assistant Professor of Psychiatry, Dr. SK. Chaturvedi, Professor of Psychiatry, conducted,12 Caregivers support Dr. A Thirumoorthy, Additional Professor, conducted workshop and education programme workshops (Funded by Dr. Ramachandra on (i) Mental Health Enrichment Training for TNPVP Chennai- N. Moorthy Foundation for Mental Health & Neurological Sciences), (a) 23-24 March 2015. 38 members participated (b) 17-18 March 15 April 2014- 17 March 2015. 520 members participated. 2015. 35 members participated (c) 4-5 March 2015. 40 members participated (d) 25-26 February 2015. 35 (e) 11-12 February 2015. Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Chethan 30-40 members participated (f ) 29-30 December 2014. 40 members B, Senior Resident, Mrs. Rathnamma, Staff Nurse, Dr. Jagadisha participated (g) 21-22 December 2014. 40 members participated (h) Thirthalli, Additional Professor of Psychiatry, coordinated 15-16 December 2014. 35 members participated (i) 17-18 November interdepartmental Sensitization programme for trainees of caregivers 2014. 35 members participated (j) 5-6 November 2014. 35 members training programme (recognized by RCI) conducted by Association participated (k) 17-18 September 2014. 35 members participated (i) of People with Disability (APD) about mental illness, 12 December 5-6 September 2014. 35 members participated. 2014. 16 members participated. Dr. N Janardhana, Assistant Professor, conducted workshop on Mrs. Glory Joseph, Nursing Tutor, conducted interdepartmental Mental illness and CBR for Certificate Course on Givers trainees, 30 workshop on Update about Recovery Oriented Services (ROSeS) March-1 April 2015. 15 members participated. at Psychiatric Rehabilitation Services, 31 January 2015. 44 members participated. Dr. N. Janardhana, Assistant Professor, Dr. Sekar, Professor and Head, conducted sensitization workshop on Child Protection for Dr. Devvarta Kumar, Associate Professor of Clinical Psychology, Community Workers, 16 February 2015. 58 members participated. Dr. Poornima Bhola, Associate Professor of Clinical Psychology, conducted national workshop on Psychological Interventions in Dr. N Janardhana, Assistant Professor, Dr. R Parthsarathy, Professor, Schizophrenia: Social Skills Training and Metacognitive Therapy Dr. D Muralidhar, Professor, Dr. K Sekar, Professor and Head, Dr. in Recovery-Oriented Practice, 21 February 2014. 50 members Shekhar Seshadri, Professor of Child and Adolescent Psychiatry, participated. conducted interdepartmental training programme for CWC and JJB Chairpersons/Members on JJ Act Implementation under ICPS and Child Counseling – (a) 2-6 December 2014. 26 members participated Psychiatric Social Work (b) 10-14 November 2014. 32 members participated (c) 3-8 November 2014. 48 members participated (d) 27-31 October 2014. 32 members Dr. N Krishna Reddy, Additional Professor, Dr. N Janardhana, participated (e) 14-18 November 2014. 36 members participated (f ) Assistant Professor, Ms. Sudha Thomas, Ph.D Scholar, conducted 15-19 September 2014. 26 members participated (g) 8-12 September half-day workshop on Sensitization Program on Mental Health 2014. 38 members participated.
National Institute of Mental Health and Neuro Sciences 99| Annual Report 2014-15
Dr. Vranda MN, Assistant Professor, conducted (i) workshop SCIENTIFIC PROGRAMMES ORGANISED OUTSIDE on lay counselors on Identification and Management of Autistic NIMHANS Children, 15 October 2014. 26 members participated (ii) workshop on Psychosocial Skills for College Students, 9 February 2015. 51 A. International members participated. Dr. Mahendra P Sharma, Professor and Head of Clinical Psychology, Dr. Kavita Jangam, Assistant Professor, conducted workshop on conducted International workshop on Applications of Mindfulness Parent Sensitization on Child Sexual Abuse, 15 November 2014. 10 in Clinical and Non-clinical Settings, All India Institute of Medical members participated. Sciences (AIIMS), New Delhi, 1 March 2015. 35 members participated. Dr. Kavita Jangam, Assistant Professor, Dr. K Sekar, Professor and Head, conducted workshop on Recent Trends in Psychiatric Social Dr. Anisha Shah, Professor of Clinical Psychology, Ms. Manjula V, Work, 6 August 2014. 20 members participated. Associate Professor of Clinical Psychology, conducted international workshop on Cognitive Behavioral Approaches to Couple Therapy, Dr. Kavita Jangam, Assistant Professor, along with Dr. LN Suman, All India Institute of Medical Sciences, New Delhi, 1 March 2015. 60 Professor of Clinical Psychology, Dr. Veena, Assistant Professor of members participated. Clinical Psychology, conducted (i) interdepartmental workshop on Crisis Counselling, 12 November 2014. 20 members participated Dr. Bindu M Kutty, Professor of Neurophysiology, conducted (ii) workshop on ACT: Awareness for Counsellors about Trauma, 3 International Symposium on Understanding Sleep to Understand the September 2014. 25 members participated. Brain, Mind and Body, 8 Asian Sleep Research Society Meet (ASRS), Bangalore, 22-24 September 2014. 400 members participated Dr. E Aravind Raj, Assistant Professor, Dr. Ameer Hamza, Associate Professor, Dr. Muralidhar, Professor, conducted (i) workshop on Dr. Prabha S Chandra, Professor of Psychiatry, Dr. SK Chaturvedi, Counseling Skills for Teachers of Government ITI- (a) 28-29 October Professor of Psychiatry, Dr. Christina Puchalski & Dr. Nagesh Simha, 2014. 23 members participated (b) 17-18 October 2014. 20 members conducted International Colloquium on Spirituality in Palliative participated (c) 14-15 October 2014. 22 members participated. Care, Bangalore, 10-11 February 2015. 150 members participated.
Dr. E Aravind Raj, Assistant Professor, conducted workshop on Dr. Prabha S Chandra, Professor of Psychiatry, conducted international Recent Trends in Psychiatric Social Work (a) 26 September 2014. 30 workshop on the Birmingham Interview for Maternal Mental Health, members participated (b) 28-29 June 2014. 30 members participated. Stafford, UK, 15-16 September 2014.
Speech Pathology & Audiology B. National
Dr. Pradeep, Speech Therapist, Dr. Aravind, Speech Therapist, Biostatistics Dr. Shivashankar, Professor and Head, co-ordinated institutional workshop on Audio-Video Methods–from Recording to Analysis: Dr. K Thennarasu, Professor, Dr. Mariamma Philip, Assistant Applications in Diagnosis & Intervention in Speech Language Professor, along with Dr. P Marimuthu, Dr. B Binukumar, Mr. Pathology and Audiology, organised by Indian Speech and Hearing Shivaji Rao, Mr. Ravi GS as resource persons conducted national Association, Bengaluru Chapter, NIMHANS, 11-12 October 2014. workshop on Biostatistics and Research Methodology, Institute of 200 members participated. Aerospace Medicine, IAF, Bangalore, 2-4 March 2015. 25 members participated.
Ayurveda Dr. K Thennarasu, Professor, conducted national pre-conference workshop on Statistical Methods using R, 30th Annual National The Department of Ayurveda conducted Hindi (Official Language) Conference of Indian Psychiatric Society, Kerala State Branch workshops on (a) 27 June 2014 (b) 20 September 2014 (c) 22 SIPSCON 2014, Ernakulam Psychiatric Society, Kaloor, Kochi, 26- December 2014 and (d) 20 February 2015. 28 September 2014.
100 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Child & Adolescent Psychiatry Wellness, Hindustan Unilever, Bangalore, 15-16 April 2014. 25 members participated. Dr. Satish Girimaji, Professor and Head with faculty members from Goa Medical College, conducted workshop on Developmental Dr. Keshav Kumar, Additional Professor, conducted special symposium Disorders in Children with Special Focus on Learning disorders, Goa, on Enhancing Brain Function: Indigenous Cognitive Retraining 22-23 November 2014. 30 members participated. Programme, National Conference on Cognitive & Neuropsychology: Challenges & Issues (NCCNP), Christ University, Bangalore, 15 Dr. Shekhar Seshadri, Professor, conducted (i) training of ICPS November 2014. 40 members participated. Counsellors, Raipur, Chhattisgarh, 29-31 May 2014. 60 members participated (ii) workshop on Child Development, Bangalore, 7-9 Dr. M Manjula, Associate Professor, Dr. Satyaprabha, Additional August 2014. 25 members participated. Professor of Neurophysiology, conducted workshop on Managing Academic Stress and Interpersonal Relationships, Jain College, Dr. K John Vijay Sagar, Associate Professor, conducted workshop on Bangalore, 25 November 2014. 100 members participated. Child Sexual Abuse, JP Nagar, Bangalore, 3 May 2014. 40 members participated. Dr. M Manjula, Associate Professor, Mr. Vidhyasagar K, PhD Scholar, Ms. Seema Nambiar, PhD Scholar, conducted workshop on Know Your Feelings and Handle them Better, Lingaraj College, Belgaum, Clinical Psychology 29 January 2015. 60 members participated.
Dr. Mahendra P Sharma, Professor and Head, conducted regional Dr. M Manjula, conducted workshop on (i) Emotion Regulation workshop on Mindfulness-Based Cognitive Behavioral Interventions Therapy for Anxiety and Mood Disorders, National Conference of the for Positive Mental Health, Smt. Kapila Khandvala College of Indian Association of Clinical Psychologists, Gandhinagar, Gujarat, Education, Mumbai, 14 March 2015. 50 members participated. 5-8 February 2015. 35 members participated (ii) Emotion Regulation Therapy for Anxiety and Mood Disorders, International Conference Dr. Uma Hirisave, Professor, conducted national (i) Symposium on Cognitive Behavioral Interventions, AIIMS, New Delhi, 4 March on Management of School Refusal, Prasanna Counseling Centre, 2015. 20 members participated (iii) Stress Management for lecturers, Bangalore, 24 January 2015. 50 members participated (ii) Workshop SSMRV Degree College, Bangalore, 26 February 2015. 20 members on Adolescent Sex Education at Titan School, Hosur, 28 January participated (b) Handling Emotions and Exam Anxiety, SSMRV 2015. 150 members participated. College, Bangalore, 19 March 2015. 80 members participated (c) Train the Trainer: Life Skills Workshop for lecturers, Mount Carmel Dr. Jamuna Rajeswaran, Additional Professor, Dr. Rajakumari K, College, Bangalore, 30 March 2015. 15 members participated. Assistant Professor, Ms. Divya Sadana, PhD Scholar, conducted a workshop on What Makes Us Human: Mapping Creativity, Dr. Poornima Bhola, Associate Professor, Dr. Rathna Isaac, conducted Empathy and Meditation. National Conference on Cognition national workshop on Digital Ethics: The Internet and Digital Ethics: and Neuropsychology: Challenges and Issues, Christ University, New Challenges for Practitioners and Clients, 5th National Bioethics Bangalore, 14-15 November 2014. 60 members participated. Conference, St. John’s Medical College Hospital, Bangalore, 13 December 2014. 70 members participated. Dr. Jamuna Rajeswaran, Additional Professor, Ms. Divya Sadana, PhD Scholar, conducted national workshop on Understanding the Dr. Poornima Bhola, Associate Professor, Ms. Ananya Sinha, Ph.D Human Brain, Fitkids organization, 3 February 2015. 50 members Scholar, Dr. Chethan Raj, conducted national workshop on Social participated. Skills Training in Clinical Workshop on Cognitive Assessment and Remediation, Psychiatry Update 2014, Kasturba Medical College, Dr. Jamuna Rajeswaran, Additional Professor, conducted national Manipal, 16 November, 2014. 80 members participated. workshop on Neuropsychological Rehabilitation, 3rd Annual Conference of Indian Federation of Neurorehabilitation, Mumbai, Dr. Sabina Rao, Dr. Aruna Rose Mary Kapanee, Assistant Professor, 6-9 March 2015. 100 members participated Dr. Prasanthi Nattala, Assistant Professor of Nursing, conducted national symposium on Rehabilitation at the Sakalawara Community Dr. Seema Mehrotra, Additional Professor, Dr. Paulomi Sudhir, Mental Health Center using a Multidisciplinary Approach, ANCIPS Additional Professor, conducted workshop on Supporting Employee 2015, Hyderabad, 11 January 2015.
National Institute of Mental Health and Neuro Sciences 101| Annual Report 2014-15
Epidemiology a part of the Youth Interfaith Pilgrimage Program, Foundation for Universal Responsibility of HH The Dalai Lama, 14 May 2014. 40 Dr. Girish N, Additional Professor, Dr. Senthil Amudhan, Assistant members participated. Professor, conducted Epilepsy Awareness Week, Kolar, 25-29 November 2014. 3146 students and 85 school teachers from 12 Dr. Bindu Kutty, Professor, in collaboration with Dr. HN schools in Kolar participated. Mallick, Professor of Physiology, Delhi, Dr. Arpita Priyadarshini, Professor of Physiology, Odisha, conducted National CME on Dr. Senthil Amudhan, Assistant Professor, conducted sensitization Sleep and Sleep Disorders. 19 November 2014. 250 members workshop on Mental Health Issues among Schoolchildren, 10 participated. October 2014, Kolar. 40 school teachers participated. Dr. BS Shankaranarayana Rao, Additional Professor, conducted national conference on Stress and Health: Frontiers of Research in Neuroanaesthesia Stress Related Diseases and Management jointly with Maharani’s Science College for Women, Bengaluru, 12-13 February 2015. 450 Dr. GS Umamaheshwara Rao, Sr. Professor, Dr. Radhakrishnan, members participated. Additional Professor, Dr. Gopalakrishna KN, Assistant Professor, conducted interdepartmental workshop on Neurocritical Care Dr. Satyaprabha, Additional Professor of Neurophysiology, Mr. (Criticare-2015), Bangalore, 5 March 2015. 60 members participated. Suresh Parmar, Human Brain Bank, Mr. Kiran Raj, Human Brain Bank, conducted interdepartmental Outreach Programme on Society Dr. Gopalakrishna KN, Assistant Professor, Dr. Kolli S Chalam, for Neurosciences-USA/ NIMHANS, Mahaveer Jain Degree Consultant, Sri Sathya Sai Hospital, Dr. Pankaj Puneetha, Consultant, College, Bangalore, 6 January 2015. 850 PU and degree college Sri Sathya Sai Hospital conducted interdepartmental workshop on students participated. Transcranial Doppler, SANCON-2015, Sri Sathya Sai Hospital, Bangalore, 15 March 2015. 200 members participated. Dr. Laxmi T Rao, Associate Professor, Dr. Arpita Priyadarshini, Professor of Physiology, Odisa, conducted 60th Annual conference of Association of Physiologists and Pharmacologists of India, Puri, Neurology Odisha, 20-22 November 2014. 250 members participated.
Dr. Girish Baburao Kulkarni, Associate Professor, conducted Dr. Laxmi T Rao, Associate Professor, Dr. HH Sudhakar, Professor departmental CME, 36th Annual MERT, 15 October 2014. 250 and Head of Physiology, KIMS, Bengaluru, conducted seminar for members participated. APPI-Bangalore chapter, Kempegowda Institute of Medical Sciences, Bengaluru, 13 October 2014. 75 members participated.
Neuropathology Nursing Dr. Anita Mahadevan, Additional Professor, Prof. P Satishchandra, th Director/Vice-Chancellor, NIMHANS conducted INSPIRE Science Dr. G Radhakrishnan, Assistant Professor, conducted 14 Annual Nurture camp 2014, Sree Siddaganga College of Arts, Science & National Conference of Indian Society of Psychiatric Nurses (ISPN) Commerce for Women, Tumkur, 25 December 2014. 250 School with the theme-Mental Health Perspectives in Emergency Care, Children participated. Ahmedabad, 31 January 2015- 2 February 2015.
Neurophysiology Psychiatry
Dr. Bindu M Kutty, Professor, conducted (i) national symposium on Dr. Mathew Varghese, Professor and Head, Dr. Srikala Bharath, Neurophysiology of Sleep & Sleep Disorders, CME on Brain and Professor, Dr. Sivakumar PT, Additional Professor, Dr. Santosh L, Cognitive Functions JNMC Belgaum, 19-21 August 2014. 200 Associate Professor, Dr. Preeti Sinha, Assistant Professor, conducted members participated (ii) national symposium on Sleep Disorders, Programs for World Alzheimer’s Month & World Elders Day, 13, 14, Pathophysiology & Management, 15-19 December 2014. 400 18, 25, 27 September, 2 October 2014. 50-100 participated in each members participated (iii) national workshop on Mind Science as programme.
102 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Dr. SK Chaturvedi, Professor, Dr. Sushma Bhatnagar, Resident, Bangalore, 6-10, January 2014. 28 members participated (ii) OST conducted interdepartmental IAPC Course Workshop on Induction Training for OST/TI staff, 17-21 June 2014. 27 members Communication skills, AIIMS, Delhi, 12 July 2014. 45 members participated (iii) Clinical Induction Training for OST/TI staff, 22- participated. 26 July 2014. 21 members participated,(iv) Comorbidity/overdose Training for OST/TI staff, 22-29 September 2014. 27 members Dr. SK Chaturvedi, Professor, Dr. Senthilreddi, Assistant Professor, participated (v) OST Induction- Refresher Training for OST/TI Dr. Seby K, PhD Scholar, Mr. Ragesh, Jr. Constultant PSW, Dr. staff, 19-21 January 2015. 27 members participated. Gayatri, PDF, conducted interdepartmental MDR TB programme, Bangalore, 30 April 2014. 60 members participated. Psychiatric Rehabilitation Dr. SK Chaturvedi, Professor, Dr. Prabha S Chandra, Professor, conducted (i) Training of trainers’ workshop for psychiatrists to train Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. BP Nirmala, primary care doctors, Pune, (a) 8-9 December 2014. 45 members (b) Associate Professor of Psychiatric Social Work, Dr. Chethan B, Senior 10-11 December 2014. 50 members participated (ii) Workshop for Resident, Mr. James, Ph.D Scholar, conducted national Symposium volunteers of Indian Cancer Society, 23 February 2015. 30 members on Teaching and training postgraduate students in psychiatric participated. rehabilitation, National conference of Indian Association for Social Psychiatry 2014, Mysuru, 21- 23 November 2014. 20 members Dr. Pratima Murthy, Professor, conducted national meeting of experts participated. to review training manuals to address risk factors for NCDs, New Delhi, 26 August 2014. 34 members participated Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Sailaxmi Gandhi, Assistant Professor, Dr. Avinash Waghmare, Sr. Resident Dr. Pratima Murthy, Professor, along with the Centre for Public of Psychiatric Rehabilitation services, Dr. Abhishek Pathak, Sr. Health conducted workshop for community health workers, 19-21 Resident of Psychiatric Rehabilitation services, conducted symposium May 2014. 35 members participated. on Recovery Oriented Services: Success Stories and Lessons Learnt. Annual National Conference of Indian Psychiatric Society 2015, Dr. Pratima Murthy, Professor, Muralidharan K, Mathew Varghese, Hyderabad, 8-11 January 2015. 20 members participated. Conference Committees, conducted Annual Conference of the Indian Psychiatric Society- South Zone (IPSOCON 2014), Bangalore, 17- Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Sailaxmi 19 October 2014. 300 members participated. Gandhi, Assistant Professor, Dr. Devvarta Kumar, Associate Professor of Clinical Psychology, conducted national symposium on Recent Dr. Geetha Desai, Additional Professor, Dr. SK Chaturvedi, Professor, Initiatives in Psychiatric Rehabilitation in a Tertiary Institution: Dr. Suresh Yadav, Sr. Resident, Dr. Eesha Sharma, MD Psychiatry, NIMHANS Experience, 5th Asia-Pacific Conference on Psychosocial conducted interdepartmental workshop on (i) Chronic Pain & Rehabilitation 2015, Bengaluru, 6-8 February, 2015. 15 members Somatization, Lucknow, 20 March 2015. 45 members participated (ii) participated. Training & Teaching Methods for Chronic Pain, Lucknow, 21 March 2015. 40 members participated. Psychiatric Social Work Dr. Venkatasubramanian, Additional Professor, Dr. S Varambally, Associate Professor, Dr. Gangadhar, Professor, conducted CME on Dr. K Sekar, Professor and Head, conducted (i) Psychosocial First Aid Neurobiology and treatment monitoring in Psychosis, 30 November Training in Phulwama, Kashmir, Emmanuel Hospital Association, 2014. 60 members participated. New Delhi, 20-22 November 2014. 30 members participated (ii) Training program for co-workers on Resilience building, SOS Dr. S Varambally, Associate Professor, Dr. Gangadhar, Professor, Village, Bangalore, 19-20 September 2014. 8 members participated in association with the Indian Psychiatric Society – Karnataka (iii) Training program on students enrichment for SOS children, Chapter, conducted state workshop on Neurobiological Approach to SOS Village, Bangalore, 31 August 2014. 25 members participated Understanding and Treatment and Improving Treatment Adherence (iv) Training program on Health Care Management during Disasters, in Psychosis, 19 July 2014. 70 members participated. Administrative Training Institute, Government of Karnataka, ATI, Mysore, 9 September 2014. 34 members participated (v) Training Dr. Prabhat Kumar Chand, Associate Professor, Dr. Arun K, Assistant program on Students Enrichment for SOS Children, SOS Village, Professor, conducted (i) Regional workshop on Oral Substitution Bangalore, 24 August 2014. 25 members participated (vi) Training Treatment (Buprenorphine) Induction Training for OST/TI staff, program on PSC for SOS mothers, SOS Village, Bangalore, 17
National Institute of Mental Health and Neuro Sciences 103| Annual Report 2014-15
August 2014. 20 members participated (vii) Training program on of the Government Primary School at Whitefield, Bangalore, Students Enrichment for SOS Children, SOS Village, Bangalore, 10 22 November 2014. 80 members participated (iv) Sensitization August 2014. 25 members participated. workshop on the Child Sexual Abuse for the School Teachers of Government School, Government schools adopted by GE Dr. K Sekar, Professor and Head, Mr. Palash Mandal, PDF, Company, Whitefield, Bangalore, 13 September 2014. 25 members conducted one day sensitization programme on Emotional First participated. Aid for Malegoan Disaster Survivors, Chaitanya Maharastra Arogya Mandali, Godegoan, 7 August 2014. 30 members participated. Dr. E Aravind Raj, Assistant Professor, conducted workshop on (i) Psychosocial Care in Disaster management, St. Mary’s Dr. K Sekar, Professor and Head, along with Dr. Pradeep, Associate College, Shirva, 11-12 March 2015. 55 members participated Professor of Epidemiology, Dr. E Arvind Raj, Assistant Professor, (ii) SPSS for lecturers, NGO staff, and PhD students, Indian in association with NIMHANS National Nodal Centre for PSS in Social Institute, Bangalore, 25-27 January 2015. 14 members Disaster Management, conducted state-level workshop on Disaster participated. Management on Comprehend Thoroughly, Prepare Optimally & Respond Resolutely, Department of Community Medicine, Dr. E Aravind Raj, Assistant Professor, Dr. Kavita Jangam, Assistant Sri Devaraj Urs Medical College, Kolar, 19 September 2014. 150 Professor, conducted workshop on (i) Psychosocial care in Disaster members participated. Management, Dept of Social Work, St. Aloysius College, Mangalore, 11 February 2015. 80 members participated (ii) Disaster Psychosocial Dr. R Dhanasekara Pandian, Additional Professor, in collaboration Care, NIDM, New Delhi, 25-29 August 2014. 16 members with Janagraha and Police Department, conducted workshop on participated. Substance Misuse among the College Students, Adithya College, Bangalore, 04 March 2015. 256 members participated. Dr. E Aravind Raj, Assistant Professor, Dr. K Sekar, Professor and Head, conducted workshop for school teachers on Psychosocial Care Dr. R Dhanasekara Pandian, Additional Professor, Dr. Pratima for Children in Disasters, UNDP – Municipal Corporation, Shimla, Murthy, Professor of Psychiatry, Mr. Arthur Julian AJ, PhD Scholar, 12-13 November 2014. 22 members participated. Mr. Soyus John, PhD Scholar, conducted (i) Orientation about Mental Health Promotion and Addiction Prevention for NSS Volunteers, BMS College for Women, Bangalore, 30 July 2014. 160 Speech Pathology & Audiology members participated (ii) workshop on Stress Management Skills for NSS volunteers, BMS College for Women, Bangalore (a) 6 August Dr. BK Yamini, Assistant Professor, conducted workshop on Oromotor 2014. 156 members participated (b) 27 August 2014. 152 members Stimulation for Children with Feeding Problems and Sensory Issues, participated. St. Johns Medical College Hospital, Bangalore, 27 October 2014. 50 members participated. Dr. N Janardhana, Assistant Professor, conducted workshop on (i) CBR and Mental Illness, APD, 15 January 2015. 30 members participated III. SPECIFIC TRAINING UNDERWENT BY THE (ii) Mental Illness among People with Disabilities Requiring FACULTY/STAFF Prosthetic and Orthotic Care, Mobility India, 13 September 2014. 40 members participated (iii) CBR and Mental Illness, Mobility India, Child & Adolescent Psychiatry 22 June 2015. 60 members participated. Dr. K John Vijay Sagar, Associate Professor, underwent two-month Dr. N Janardhana, Assistant Professor, Ms. Chaitra, Psychiatric Postdoctoral Fellowship Training, University of Florida, Gainesville, Social Worker, Ms. Divya Ballal, PhD Scholar, conducted USA, 5 October 2014-5 December 2014. (i) sensitization workshop on Child Sexual Abuse for the students, Government Higher Primary School, Whitefield, 29 December 2014. 300 members participated (ii) workshop Clinical Psychology on Mental Health Problems in Children for school teachers of Rastrothana Vidya Samasthe, Rastrothana Vidya Samasthe, Dr. Roopesh BN, Assistant Professor, underwent three-day training Thanisandra, 27 December 2014. 100 members participated (iii) programme on Qualitative Research Methods and Analysis, Christian Sensitization workshop on Child Sexual Abuse for the students Medical College, Vellore, 12-14 May 2014.
104 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Epidemiology Nursing
Dr. Senthil Amudhan, Assistant Professor, underwent 10 weeks Ms. Alphy Thomas, Ms. Amrita Kuriakose, Ms. Arpitha E. Jolly, Mrs. training on Infectious disease epidemics, The University of Hong Lavanya D, Mrs. Rebeca K, Ms. Rituparna Samanta, Ms. Sheeba S. Kong through edX, 23 September 2014 -2 December 2014. Daniel, Mrs. Usha S.N (II year M.Sc Psychiatric Nursing students) underwent one week Administration posting Mahe, Manipal, 2-7 February 2015. Neurology Ms. Asha Vijayan, Mrs. Harshitha J, Mrs. Jesna C.A, Ms. Jisha Dr. P Satish Chandra, Director/Vice-Chancellor, underwent five-day Jose, Ms. Jiya G. Panthanalil, Ms. Linsu Thomas, Ms. Maya Sahu, MEG Training Programme, Helsinki, Finland, 5-9 May 2014. Mrs. Nihil Savio, Mr. Subin Scaria (I year M.Sc Psychiatric Nursing Students) underwent one week Experience in Advanced Nursing Dr. Sanjib Sinha, Additional Professor, underwent five-day MEG Practice, St. John’s College of Nursing, Bengaluru, 23-28 February Training Programme, Helsinki, Finland, 5-9 May 2014. 2015.
Psychiatry Neuromicrobiology Dr. Prabha S Chandra, Professor, underwent one month Liverpool Dr. Ravikumar R, Professor and Head, underwent one day Fellowship India Fellowship training, University of Liverpool, UK, September in Healthcare Quality Management, Bangalore Baptist Hospital, 2014. Bangalore, 31 May 2014. Dr. G Venkatasubramanian, Additional Professor, underwent one day Dr. Nagarathna S, Additional Professor, underwent one day training training in Workshop on Transcranial Direct Current Stimulation. in CME on Basics of Research Design, Research Methodology, 1st International Brain Stimulation Conference, Singapore, 1 March Biostatistics and Scientific Medical Writing and Publishing, BMCRI, 2015. Bangalore, 28 March 2015. Dr. Urvakhsh M Mehta, Assistant Professor, underwent six- month training in Neuroimaging and Neuronavigational TMS, Neuropathology Wellcome Trust/DBT India Alliance Early Career Fellowship, Beth Israel Deaconess Medical Center & Massachusetts Mental Dr. Anita Mahadevan, Additional Professor, Mr. Suresh Parmar, Health Center, Harvard Medical School, Boston, USA, 1 May-31 Human Brain Bank, underwent three-day training in hands- October 2014. on workshop on Flow Cytometry Applications, Advanced Flow Cytometry Lab, Neurobiology Research Centre (NRC) and Neurovirology Dept, NIMHANS, Bangalore, 16-18 June 2014. Speech Pathology & Audiology
Neurosurgery Dr. BK Yamini, Assistant Professor, Dr. Aravind Kumar R, Speech Therapist, underwent one day training in Indo-German Seminar Dr. Nupur Pruthi, Associate Professor, underwent three-month on Medical Imaging in Neuro Sciences: Diagnosis, Analysis and Research Fellowship in Microsurgical Neuroanatomy, Yeditepe Treatment, NIMHANS, Bangalore, 4 December 2014. University School of Medicine, Istanbul, Turkey, 1 October - 29 December 2014.
National Institute of Mental Health and Neuro Sciences 105| Annual Report 2014-15
Academic activities funded by Dr. Ramachandra N Moorthy Foundation for Mental Health and Neurological Sciences
Dr. Ramachandra N Moorthy Foundation for Mental Health and 19. Workshops (five) to assess medically unexplained symptoms Neurological Sciences funded 23 activities/programmes during the year (MUS), and publishing/printing of the manual on MUS (March 2014- 2015. The activities/programmes are: 2015 onwards). 1. Caregivers Support & Education Programme Workshops, 20. A social skill training program for school going children at Poorna Psychiatric Rehabilitation Services (October 2014 to April 2015) Learning Centre, Bangalore. 2. Third Early Career Mental Health Professionals Workshop, with 21. Workshop on how to start and run psychiatric rehabilitation services Prof. Norman Sartorius and Dr. Mohan Isaac ( January 2015) in various setups like OPD, inpatient, stay facilities, community 3. Development of an Innovative Educational Programme, an (April 2015) internet- based training programme in fundamentals of counselling 22. Publication of a user’s manual with theoretical/conceptual and adults for management of common psychological issues practical information about social skills assessment and training in 4. Capacity building for teachers of Industrial Training Institutes to persons with schizophrenia (April 2015) handle psychosocial stresses of students ( June/July 2014) 23. Dissemination of neuro-psychiatric information, education and 5. Establishment of an Information Centre for mental health and communication material to related public, April 2015 preventive neurology for the public ( July 2014) The Third Leadership and Professional Skills Workshop for Early 6. CME on Consultation-Liaison Psychiatry: Concept, Practice & Career Psychiatrists, was held in January 2015, and for the first time Challenges ( July 2014) invitation was extended to participants from the SAARC countries. The workshop saw participation from Bangladesh and the Armed 7. Sensitization workshop for Government Primary School Teachers Forces. on Child Abuse and Neglect (September 2014) Dr. Ramachandra N Moorthy Foundation for Mental Health and 8. Psychodynamic Psychotherapy Workshop (October 2014) Neurological Sciences at NIMHANS was created through a generous 9. Domestic Skills Workshop: A Workshop for the People, by the donation by Dr. Ramachandra N Moorthy, an Indian-born Psychiatrist People, of the People (for six months from August 2014) in Vancouver, Canada. One of the major goals of the Foundation is to promote training and academic activities in the field of mental health 10. Workshop titled ‘Innovative Teaching Techniques in Psychiatric in India. The total donation was about Rs. 3.35 crore, and it has been Nursing’ (November 2014) decided to use the annual interests generated (of about Rs. 30 lakh) for 11. Workshop on Relapse Prevention in Alcohol Dependence ( January various academic activities. A Committee has been formed under the 2015) Chairmanship of the Director/Vice Chancellor of NIMHANS and 12. Workshop on Incorporating Evidence-based Practice (EBP) into includes the Registrar, Deputy Finance Officer, Visiting Professor Dr. Staff Development ( January 2015) Mohan K Isaac, Dr. Ramachandra N Moorthy, and faculty members from the departments of Clinical Psychology, Psychiatric Social Work, 13. Workshop to promote awareness on Childhood Behavioural and Nursing. The Member Secretary coordinates the activities funded Disorders and its Management: Multi-disciplinary Approach by the Foundation. ( January 2015) 14. Workshop to enhance strategies for strengthening mental health issues among youth in India, December 2014 15. Printing the Kannada version of the manual ‘Effective Care Giving in Dementia: A Learning Module for Caregiver’ for caregivers of persons with dementia. 16. Observation of International Day of Persons with Disabilities, Psychiatric Rehabilitation Services, NIMHANS (December 2015) 17. Workshop on Community Mental Health Nursing (March 2015) 18. One-day National workshop entitled ‘Psychological Interventions in Schizophrenia: Social Skills Training and Metacognitive Therapy in Recovery-Oriented Practice’, organized by the Psychiatric The Third Leadership and Professional Skills Workshop for Rehabilitation Services (21 February 2015) Early Career Psychiatrists
106 | National Institute of Mental Health and Neuro Sciences New Facilities
Centre for Addiction Medicine Complex encompassing Women’s Treatment Wing, Drug Toxicology Laboratory and Virtual Knowledge Centre was inaugurated by Dr. Harsh Vardhan, Hon’ble Minister of Health and Family Welfare, Government of India and President, NIMHANS on 16 August 2014. Shri. U.T. Khader, Minister for Health and Family Welfare, Government of Karnataka and Dr. Sharan Prakash R. Patil, Hon’ble Minister for Medical Education, Government of Karnataka and Vice-President, NIMHANS were the Guests of Honour.
Advanced MR PET Scan Center, first of its kind in the public sector, was inaugurated by the Hon’ble Prime Minister of India, Shri. Narendra Modi on 18 February 2015, during the 19th Convocation of NIMHANS.
State-of-the-art Digital Subtraction Angiographic (DSA) facility was inaugurated on 28 December 2014 by Shri. Jagat Prakash Nadda, Hon’ble Union Minister for Health & Family Welfare, Government of India in the presence of Dr. Sharan Prakash R. Patil, Hon’ble Minister for Medical Education, Government of Karnataka. Central Facilities
Table 2: Awards and Publications Neurobiology Research Total Publi- Laboratory Awards Centre (NRC) cations Translational Psychiatry Laboratory 4 24 Neurobiology Research Center (NRC), a sophisticated common Multi-modal Brain Image Analysis Laboratory 5 8 research facility, continues to provide a platform to promote Metabolic Laboratory 1 11 interdisciplinary and inter-institutional collaborative research Neuro-Oncology Lab 2 8 at NIMHANS. The centre provides infrastructure to support Molecular Genetics Laboratory - - Bioinformatics Laboratory 1 8 translational research and development of cutting-edge technology Cell Culture and Stem Cell Biology 1 2 in frontier areas of neuroscience. It houses 15 research laboratories Electrophysiology Laboratory 5 5 and four central facilities. Most of the laboratories continue to receive Optical Imaging Lab 1 1 extramural grants for their research works from DBT, DST, ICMR, Neuromuscular laboratory 2 15 CSIR among others. During the year 2014-15, a total of about Neurotoxicology laboratory - 1 50 projects were funded by these funding agencies to the different Cognitive Psychology & Cognitive 2 - research laboratories. The mandate of the NRC is that all the central Neurosciences Laboratory facilities and research laboratories are common facilities, to be shared and used by scientists, research scholars and students at NIMHANS. Table 3: Purchase of equipment during the year 2014-15 There has been a significant increase in the number of students/ Laboratory Equipment purchased researchers using this facility in 2014-2015, compared to the previous Multi-modal Brain Advanced Parallel Computing Facility (including year (171 in 2014-15 against 124 in 2013-14). The students/research Image Analysis server and workstations) Laboratory scholars who are currently using the facility include PhD (87), MPhil Neuro-Oncology Mini-PROTEAN® Tetra Cell,2-gel vertical (8), post-doc (6), SSO/SRF/JRF (total 24) and trainees (46). During Lab electrophoresis system the review period, 11 PhD students completed their course. Cell Culture and Refrigerator and Autoclave (TOMY digital Stem Cell Biology autoclave) Table 1: Research projects during the year 2014-15 Neuromuscular Dry bath and semidry blotting system; 80deg Laboratory freezer, stereo zoom microscope, dancing shaker Funded projects Non-funded (provided from Human Brain Bank for use) Laboratory Com- Ongo- Com- Ongo- Neurotoxicology pH meter, vortex mixer, gel rocker and table-top pleted ing pleted ing Laboratory spinner. Translational Psychiatry 2 8 - 2 Laboratory Multi-modal Brain Image Analysis - 6 - - Laboratory Common Facilities Advanced Flow Cytometry - 5 - - Laboratory 1. Human Brain Tissue Repository (Human Brain Bank; Metabolic Laboratory 2 11 3 1 Officer In-charge: Dr. SK Shankar) Neuro-Oncology Laboratory 2 3 5 5 Molecular Biology Laboratories- Communicable and Non- - 1 - 2 The Human Brain Bank, located in the ground floor of NRC, has Communicable actively continued its mandate of (a) collection of donated brains from Cell Culture and Stem Cell Biology 2 3 1 2 cases of neurodegenerative and infective conditions (b) collection Electrophysiology Laboratory 4 5 4 8 of brains from victims of road traffic accidents (RTA) as relatively Optical Imaging Laboratory - 4 1 4 normal controls (c) distribution of the brain tissue, CSF and serum to Molecular Genetics Laboratory - - - - research to scientists from all over the country. The brain specimens Bioinformatics Laboratory 4 4 9 10 and CSF/serum are collected after obtaining written informed consent Neuromuscular Laboratory 2 2 - 2 from close relatives. During 2014-2015, brains were collected from Neurotoxicology Laboratory - 3 - 2 Cognitive Psychology & Cognitive cases of RTA and diseased states including stroke, CNS infections 1 - - - Neurosciences Laboratory including HIV and neuropsychiatric disorders. In addition, 7 fresh
108 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 brain biopsy samples following epilepsy surgery were collected and samples of human brains. During 2014-2015, a total of 2661 students stored. These samples were stored at -86oC. Apart from this, 53 from 33 schools and colleges visited the Brain Museum. In addition, cadaver hearts from RTA victims were collected and provided for many foreign scientists and dignitaries, who came to NIMHANS homograft transplantation to Jayadeva Institute of Cardiology and for scientific collaboration, visited the Brain Museum and greatly Research Centre, Manipal Hospital and Narayana Hrudayalaya, appreciated the unique collection and the means of display. The Brain Bangalore. Required brain tissues from various anatomical areas, CSF Museum was also widely reported in print and electronic media. samples from normal controls and diseased states were distributed to The total number of visitors to the Neuropathology Brain Museum 10 scientists throughout India for their research work. Proteomics during 2014-2015 stood at 4184, in contrast to 3170 the previous year. studies, in collaboration with the Institute of Bioinformatics, were The visitor footfall has been increasing every year owing to the wide continued in cases of tuberculous meningitis, cryptococcal meningitis, dissemination of information about the facility in the print, electronic toxoplasma encephalitis, cerebral malaria, rabies encephalitis and and social media. The staff of Human Brain Bank regularly conducts schizophrenia. In these studies, several seminal observations were guided tour for the visitors explaining the nature and importance of reported. Ongoing projects include proteomic studies of pituitary the exhibited specimens including the human brain, spinal cord and gland and olfactory region. Nine research articles have been published other organs. The museum permits the visitors to touch and feel the utilizing the material from the Brain Bank with the principal co- organs, providing unique experience to them. Several posters have ordinator and associate co-ordinator as co-authors. also been displayed to educate the public about brain and its related disorders. The museum has prepared 17 posters (3ft X 3ft) as a public Brain Bank is actively involved in the promotion of neuroscience awareness initiative and these are being used regularly in the local and public awareness programmes, especially about cadaver organ exhibitions organized by various schools/colleges and Indian Epilepsy donation and brain donation. This has led to an increase in the Association. To accommodate the increasing number of specimens, number of donors who have pledged their brain for research after the museum is being expanded. death (9 citizens registered as donors this year). Brains of seven deceased patients/donors were acquired with the permission of their 3. Central facility for Millipore Water Purification system, families for research purpose during the year. Liquid nitrogen and Waste Disposal
Brain Bank provided tissues for the following research: (i) Host The high capacity Millipore (ELIX 70 Ltr/Hr and Synergy) water response profile of human brain proteome in toxoplasma encephalitis purification system, on the ground floor of the NBRC, has been co-infected with HIV (ii) Mass spectrometry-based proteomic functional since July 2014. The system provides 1560 litres/month investigation of human olfactory bulb (iii) Mass spectrometry- of purified water for multiple laboratory and hospital applications based proteomic investigation of human pituitary gland (iv) including ultrapure water required for molecular biology research. Identification of smokeless tobacco induced signaling in oral cancer (v) Phosphoproteomic profiling in gallbladder cancer (vi) Curcumin The NBRC is also provided with a dedicated central waste disposal induced signaling in oral cancer (vii) Phosphoproteomic analysis in facility on the ground floor which is equipped with a large volume head and neck cancer (viii) Analysis of transcriptome and epigenetic autoclave and a shredder for hospital / lab waste disposal. changes in neurotoxic model - mitochondrial function (ix) Tripartite Containing Motif 32 Modulates Proliferation of Human Neural The liquid nitrogen (LN2) storage tank of capacity 900 litres set up Precursor Cells in HIV-1 Neurodegeneration. in the NBRC serves as a source of supply for liquid nitrogen which is being used regularly by several laboratories at the Centre. This To promote public awareness and education amongst schoolchildren, facility is also being used routinely by some of the other laboratories three outreach programs were conducted in various schools and in the Administrative Block of NIMHANS such as Departments of colleges, where more than 1000 students enthusiastically participated Neurovirology, Neuropathology, Neurochemistry, Neurophysiology to gain knowledge about the human brain and brain disorders. and Biophysics. In the year 2014-2015, 360 litres/ month of LN2 was disbursed to the different laboratories. 2. Neuropathology Brain Museum (Dept. of Neuropathology; Head: Dr. Yasha TC, Officer In-charge: Dr. SK Shankar) 4. ICMR Centre for Advanced Research for Innovation in Mental Health and Neurosciences The Neuropathology Brain Museum (Human Brain Museum), the only one of its kind in the country, is located in the Neurobiology Realizing the leadership potential shown and the rapid progress made Research Centre. This unique facility has become a centre of by NIMHANS in the field of Mental Health and Neurosciences, attraction for the students of various colleges and schools and the Indian Council of Medical Research (ICMR) in association with tourists alike to have a look at the diverse collection of specimens and the Department of Health Research (DHR) established the Centre
National Institute of Mental Health and Neuro Sciences 109| Annual Report 2014-15 for Advanced Research for Innovation of Mental Health and abnormalities in schizophrenia, neuromodulatory effects of tDCS Neurosciences with a dual component of manpower development to in schizophrenia, eye movement abnormalities in schizophrenia achieve a critical mass of technical person and propel translational and OCD, EEG/ERP abnormalities in schizophrenia and OCD, research to take scientific investigation to the bedside medicine. The neurohemodynamic abnormalities in schizophrenia using functional centre, located in the third floor of Neurobiology Research Centre, near infrared spectroscopy and imaging-genetics studies in OCD. presently has three projects sanctioned after evaluation by the expert committee. Patient care services: TransPsych Lab critically facilitates provision of transcranial direct Ongoing research activities: current stimulation for schizophrenia patients. Research staff in the 1. Development of Neuroscience Educational Material for lab contributes to the clinical services of the schizophrenia clinic as popularizing Neuroscience under Human Brain Bank well as the metabolic clinic.
2. Translational Research in Amyotrophic Lateral Sclerosis Multi-modal Brain Image Analysis Laboratory (MBIAL) (Officer (ALS) – Development of Biomarkers for diagnosis, monitoring In-charge: Dr. John P. John) disease progression and evaluation of toxicity. This laboratory aims at integrating the acquisition and analysis of 3. Development of ELISA and evaluation of the potential of 14- multiple modalities of brain imaging for a more comprehensive 3-3 protein as a biomarker of neural injury / Neurodegeneration understanding of brain structure, function and signalling in various with special reference to Creutzfeldt –Jakob disease. neuropsychiatric disorders. This facility aims at employing an integrated multi-disciplinary approach to examine brain structure and function in health and disease through active collaborations between Research Laboratories various departments both within and outside the institute. Research projects being undertaken at MBIAL include multi-modal imaging- Translational Psychiatry Laboratory (Officer In-charge: Dr. G. genomics studies in schizophrenia and dementia, as well as of certain Venkatasubramanian) cognitive processes; these projects are funded by the Department of Science and Technology (DST) and Department of Biotechnology The Translational Psychiatry Laboratory (TransPsych Lab) facilities (DBT). Many PhD scholars, MD (Psychiatry) post-graduates as well have been created towards initiation of an integrated clinical research as trainees from other departments of NIMHANS as well as external facility with focus on translational applications in psychiatry. This trainees have utilized the facility for obtaining training. research facility is supported by research grants from Welcome Trust / DBT India Alliance Senior Fellowship Award as well as Completed research activities: from the Department of Biotechnology. The goal of the TransPsych (i) EEG power spectral and complexity analyses in neuroleptic- Lab is to evaluate and establish composite biomarkers involving naïve patients with recent-onset schizophrenia; (ii) Novel landmark- neuroimmunobiological abnormalities in Schizophrenia and other based definition of the rostral prefrontal cortex and evidence for disorders like Obsessive Compulsive Disorder, Bipolar Affective neurodevelopmental deviance of the rostral prefrontal cortex in Disorder and Alzheimer’s disease. The vision of this Centre is to create schizophrenia; (iii) Corpus callosal abnormalities in schizophrenia and a translational research facility of international caliber, integrating gender dimorphism of corpus callosum; (iv) fMRI brain activations clinical, neuroimmunological, neuropathological, neuroimaging and deactivations during word generation and aberrations of the and advanced computational research techniques to examine the same in schizophrenia; (v) Development of a task-based ensemble ‘Neuroimmunopathogenetic Model for Schizophrenia’. synchrony measure of EEG using Frobenius norm (in collaboration with Dr. Kaushik Majumdar, Indian Statistical Institute, Bangalore). Completed research activities: Research activities completed during the year 2014-15 include Ongoing research activities: evidence for inteleukin-6 and telomere abnormalities in schizophrenia, Presently, the major thrust areas of research at MBIAL include: clinical and neurobiological studies on the effect of transcranial (i) Multi-modal imaging-genomics approach to investigating the Direct Current Stimulation (tDCS) in schizophrenia, white matter link between impaired word generation and aberrant glutamatergic abnormalities in schizophrenia and OCD. function in schizophrenia (in collaboration with Prof. Sanjeev Jain, Department of Psychiatry and Dr. Jitender Saini, Department of Ongoing research activities: Neuroimaging and Interventional Radiology); (ii) Examination Ongoing research activities focus on examining the of aberrant neural synchrony in schizophrenia using EEG, fMRI neuroimmunogenetic and neuroplastic correlates of brain and polysomnography (in collaboration with Prof. Bindu Kutty,
110 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Department of Neurophysiology); (iii) Study of the link between (v) Enhancement of temozolomide and radiation induced damage blood biomarkers and neuroimaging parameters in schizophrenia and in malignant glioma cell lines by 2-deoxy-d-glucose. major depression (in collaboration with Dr. Sarada Subramaniam, Additional Professor of Neurochemistry); (iv) Examination of the Ongoing research activities: link between candidate gene polymorphisms and neuropsychological (a) A Comparative Study of Innate and Cell Mediated Immune and information processing deficits in schizophrenia; (v) Network Responses in Human-Immunodeficieny virus infected connectivity in minimal cognitive impairment and early dementia (in individuals with and without Neurotuberculosis collaboration with Prof. Srikala Bharath, Department of Psychiatry); (vi) Resting state functional networks and cognition in healthy (b) Immune signatures of responses to Dengue Virus infection ageing (in collaboration with Prof. Mathew Varghese, Department of Psychiatry); (vii) Diffusion tensor imaging and apoE polymorphisms (c) Analysis of brain infiltrating lymphocytes in mouse brain in Alzheimer’s dementia; (viii) Neural correlates of well-being following vaccination against Rabies or infection with Rabies associated with mindfulness meditation (in collaboration with Prof virus. Bindu Kutty, Department of Neurophysiology); (ix) Mathematical modelling of gene-gene and protein-protein interactions affecting (d) Study on immune dysfunction during post-partum psychosis brain morphometry in schizophrenia (in collaboration with Dr. Meera Purushotham, Molecular Genetics Laboratory); (x) Brain functional (e) Analysis of cellular immune responses in patients with connectivity underlying conscious awareness and its aberrations in Schizophrenia. schizophrenia (in collaboration with Prof. Sangeetha Menon, National Institute of Advanced Sciences, Bangalore); (xi) Machine learning Metabolic Laboratory (Officer In-charge: Dr. Rita Christopher) approaches using multimodal neuroimaging metrics in schizophrenia; (xii) Functional magnetic spectroscopy (fMRS) in schizophrenia The prime objective of this Metabolic Laboratory is to provide and major depression; (xiii) Development of computerized cognitive diagnostic services for identification of neurometabolic disorders and intervention programs (in collaboration with Dr. Paulomi Sudhir, carry out translational research in neurometabolic and cerebrovascular Additional Professor of Clinical Psychology and Prof. Shivshankar, disorders. The laboratory conducts high-throughput, mass Department of Speech Pathology and Audiology). spectrometry (MS)-based screening for Inborn Errors of Metabolism (IEM). This facility, which is the first of its kind in a government Advanced Flow Cytometry Laboratory (Officer In-charge: set-up in the country, analyses samples from all over India as well as Prof. Ravi V) from other neighbouring countries. The lab has obtained satisfactory results in the Newborn Screening Quality Assurance Program The Advanced Flow Cytometry Laboratory, equipped with an conducted by the Center for Disease Control and Prevention (CDC), advanced four-laser BD FACS Aria III cell sorter and a three-laser Atlanta, USA. FACS Verse analyzer enables sorting and analysis of single cells based on multiple parameters respectively. Students /researchers from Completed research activities: various other departments of the Institute use this facility for their In the previous year, a high-throughput, mass spectrometry-based research works under the supervision of a Senior Scientific Officer. method using dried blood spots was established for identification of Gaucher, Pompe, Niemann-Pick, Krabbe and Fabry diseases. Using Completed research activities: this method, samples were tested to determine the prevalence of (i) Clinical and immunological profile of patients with Subacute these disorders in the Indian population. A cost benefit analysis for Sclerosing Pan Encephalitis. conducting newborn screening for these disorders was carried out. A study to determine the role of vitamin D status and vitamin D (ii) Flow cytometry based detection of dysferlin protein expression receptor gene variants on vascular risk was carried out in patients with in CD14 positive monocytes from peripheral blood samples of ischemic stroke. patients with Dysferlinopathy. Ongoing research activities: (iii) Targeting Brain Energy Metabolism in CNS Diseases: Presently, studies are being conducted to identify the differentially Malignant Gliomas as Illustrative Example Isolation of Primary expressed microRNAs in the plasma of patients with cerebral small Cell lines from High Grade Glioma vessel disease and to determine their utility as molecular biomarkers to diagnose this condition. Expression profiling of microRNAs (iv) Immune responses in patients with mild, moderate and severe and elucidation of their possible role in the formation and rupture infection by influenza virus (H1N1) infection. of intracranial aneurysms is also being done. A study to determine
National Institute of Mental Health and Neuro Sciences 111| Annual Report 2014-15 whether Vitamin D insufficiency is associated with increased risk for A pilot study on the proteomic and phosphoproteomic profile severe vascular cognitive impairment in the elderly, establish whether on Medulloblastoma, led the researchers to identify different the gene variants of the Vitamin D metabolic pathway could predict Phosphorylation patterns and differential protein expression across the risk for cognitive decline and elucidate the possible mechanism by various histological subtypes of Medulloblastoma. The researchers which low vitamin D status could increase risk for vascular cognitive further classified medulloblastomas molecularly using the IHC impairment, is being carried out. markers GAB1, YAP1 and β-catenin. The novel biomarkers that will emerge from the proteomic profiling data is being validated on Patient care services: retrospective set to identify biomarkers of diagnostic and prognostic 4506 samples were screened for IEM using tandem mass spectrometry significance
Neuro-Oncology Lab (Officer In-charge: Dr. Vani Santosh) Patient care services: Self-Sustaining Diagnostic Molecular Neurooncology Facility: The Neuro-Oncology Lab was established in September 2011 with 1p19q status using FISH technique is being routinely performed a prime objective of translational research in Neuro-Oncology. In in the lab. A 90 patient samples were studied and reported, during addition to tissue based research carried out at the lab, collaborations the review period. MGMT methylation status for diagnostic with core biological research institutes have promoted dissection of purpose has been performed on 38 patient samples. The lab is various pathways related to gliomagenesis. receiving requests for these molecular diagnostic tests from all over the country. Completed research activities: Evaluation of expression patterns of PP1A, MMPs and SOD2 have Molecular Biology Laboratories – Communicable and Non been submitted as original research articles for publication in various communicable (Officer In-charge: Prof. Ravi V) journals. Research activities completed during the year 2014-2015 include patho-biological characterization of WHO grade III gliomas, The Molecular Biology labs (Communicable and Non- using various markers by techniques such as IHC, FISH and PCR Communicable Disease labs) are being used routinely by students studies. These have been currently characterised with respect to the from various departments at NIMHANS namely Human Genetics, well-established biomarkers such as the wtIDH1, mIDH1, ATRX Molecular Genetics, Biophysics, Bioinformatics, Neuropathology, etc. Glioblastoma cohort has also been characterized with respect Neurochemistry, Neurovirology, Neurophysiology, Neuromicrobiology, to IDH1 and ATRX expression. The expression pattern of NNMT etc either for performing Real Time PCR / Conventional PCR assays and MELK in glioblastoma tumor tissue has been evaluated and or for analysis of gels / blots on the chemiluminescence enabled Gel their expression pattern across various grades of astrocytoma has Documentation system. Two rooms in this facility are being used for been noted. Evaluation of single nucleotide polymorphism studies Cell culture work by the Molecular Genetics Lab. in patients with GBM has been initiated and EGFR SNP R497K, the heterozygous status of which to be strongly associated with poor Completed research activities: prognosis, has been identified. Employing gene expression arrays, Immune responses in patients with mild, moderate and severe differential gene expression between the core and the invasive front of infection by influenza virus (H1N1) infection glioblastoma tumor tissues has also been identified. Ongoing research activities: Ongoing research activities: Faculty and students in the two laboratories are carrying out a The researchers are currently validating the expression of various comparative study of innate and Cell Mediated Immune Responses novel markers through Immunohistochemistry on the archived in Human Immunodeficiency virus infected individuals with and specimens of glioblastoma invasive front and core tumor tissue. without Neurotuberculosis, studying the molecular aspects of the Zymography technique has been newly initiated in the lab for the pandemic Influenza A 2009 (H1N1) virus with special reference to evaluation of MMP activity in tumor tissue. The researchers are host immune factors, offering molecular diagnosis for Dengue and also validating the genes identified on microarray, distinguishing studying the epidemiology of Dengue virus and immune signatures between 1p19q codeleted and intact anaplastic oligodendroglial during responses to dengue virus infection. tumors. Following clinicopathological evaluation of various grades of meningiomas, various chromosomal deletion statuses (diagnosed Patient care services: by FISH studies) in a distinct entity termed chordoid meningioma Evaluation of Dengue diagnosis by conventional and Real time PCR is being evaluated and its relation to the clinico-pathological pattern assays and Dengue Virus Epidemiology studies, diagnosis of viral is being studied. infections of the central nervous system.
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Molecular Genetics Laboratory (Officer In-charge: Prof. Sanjeev glycoproteomic analysis of various human tissues, body fluids and cell Jain) lines to understand the cellular biology. The main areas of thrust at this laboratory are study of proteomic map during the development Molecular genetics laboratory carries out research projects and of human brain, chronic meningitis such as tuberculous meningitis, diagnostic work in neuropsychiatric conditions (schizophrenia, cryptococcal meningitis, rabies encephalitis and schizophrenia. bipolar affective disorder, obsessive compulsive disorder, dementia, The laboratory is involved in the execution of several projects Huntington’s disease, spino-cerebellar ataxia, Duchene’s/Beckers in collaboration with the scientists from the Departments of muscular dystrophy and spino-muscular atrophy). Till date, over Neuropathology, Neurology, Neuromicrobiology, Neurophysiology, 14000 DNA samples from neuropsychiatric conditions and 1000 Neurovirology, Neurooncology, Neuropsychiatry and Neurochemistry. control samples have been stored at laboratory to facilitate research on candidate genes and epigenetic work for the purpose of research Completed research activities: projects, PhD theses, MD theses and diagnostic works. During the i) The pilot study to analyse the total proteome and period under review, 1 PDF, 9 PhD, 10 MD students and 9 BE/MSc phosphorpoteome (pSer/Thr) of Medulloblastoma: This students were trained. analysis resulted in identification of 3,641 proteins in proteomic analysis and 513 phosphosite corresponds to 352 proteins in Completed research activities: phosphoproteomic analysis. A total of 85 proteins in classical Projects involving novel gene modifiers of Apolipoprotein E gene in histological type, 234 proteins in Desmoplastic/nodular Alzheimer’s dementia, genetics of movement disorders and epigenetics and 227 proteins in Anaplastic differentially expressed were of alcohol dependence were completed. differentially regulated.
Ongoing research activities: ii) Quantitative proteomic analysis of cerebrospinal fluid from The procedures for leukocyte isolation from peripheral blood, Epstein tuberculosis meningitis co-infected with HIV: In this study, the Barr virus supernatant generation and lymphoblastoid cell line researchers have identified 2,164 proteins of which 460 proteins establishment (LCLs) were standardized. LCLs were established are up-regulated and 270 proteins down regulated. Upregulated for 50 samples with neuropsychiatric conditions till date (Dementia, proteins have been identified in this study. bipolar affective disorder, obsessive compulsive disorder, Huntington’s disease and spino-cerebellar ataxia). Using lymphoblastoid cell line iii) Comparative proteomic analysis of brain tissues from as model system, thesis work is carried out on Alzheimer’s disease, Cryptococcal meningitis co-infected with HIV, Toxoplasma bipolar affective disorder and obsessive compulsive disorder samples. encephalitis co-infected with HIV, Tuberculous meningitis The CoE grant under the DBT is making progress. Candidate gene co-infected with HIV: The iTRAQ-based comparative study and epigenetic work are carried in alcohol dependence samples. has resulted identification of 3,500 proteins. The researchers identified 3,541 proteins of which 735 were found to be Patient care services: differentially expressed in toxoplasma encephalitis while Genetic testing for DMD/BMD and SMA is carried out by MLPA 639 and 820 were found to be differentially expressed and PCR-RFLP method respectively. The diagnostic work was in cryptococcal meningitis and Tuberculous meningitis initiated as self-sustaining project from June 2014. A total of 275 respectively. Immunohistochemistry-based validation has been individuals and their families utilized the diagnostic services (78 done for HLAB, TF and PERLP to confirm the regulation of clinically suspected SMA samples and 197 clinically suspected DMD the molecule. samples). Molecular diagnosis was positive for 38 SMA samples and 102 DMD samples. iv) Comparative proteomics of mouse cerebrum infected with CVS-11 strain of rabies virus at different time points: This A total of 178 individuals and their families availed the services for study was performed to see temporal changes in the total genetic counselling and testing for the movement disorders (HD/ proteome on day 1/3/7 after infection as compared to uninfected FRDA/SCA) of which 74 individuals were confirmed by genetic mouse cerebrum tissue samples. A total of 2,971 proteins were testing. identified, of which 1,400 proteins were differentially regulated.
Bioinformatics Laboratory (Officers In-charge: Dr. Keshav Prasad, v) Comparative mitochondrial proteomic analysis of muscle Dr. SK Shankar) samples from dystrophenopathy, distal myopathy with rimmed vacuoles, inflammatory myopathy and control individuals: The NIMHANS-IOB Bioinformatics and Proteomics Laboratory Mitochondrial proteins were enriched to study their differential is actively involved in genomic, proteomic, phospoproteomic and expression pattern in disease conditions. Total proteins identified
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stood at 1,368, out of which 448 belong to known mitochondrial iv. Comparative proteomic analysis of rabies virus infected BHK21 proteins. Of these, 168 proteins were found to be differentially and Neuro2A cell lines expressed in disease conditions with respect to the control. v. A proteomic map of human brain developmental stages from vi) Study of host responses in the brain of cerebral malaria patients: prenatal to adult. Equal amount of proteins were isolated from the frontal lobe of cerebral malaria patients and control individuals. LC-MS/MS Cell Culture and Stem Cell Biology (Officer In-charge: analysis resulted in identification of 3,633 host proteins, and of Dr. TR Raju) these, around 80 proteins were differentially regulated. Well-equipped with the best possible infrastructure, Cell Culture vii) Proteome map of adult human pituitary glands: A total of 2,681 and Stem Cell Biology Lab laboratory aims at delineating the proteins were identified, and 1,001 of these were novel pituitary pathomechanisms of neurodegenerative diseases including ALS and proteins and 149 signal peptide proteins. PD using in-vitro model systems. Additionally, research towards understanding the regenerative mechanisms activated following viii) Proteomic changes in the human brain from cases of an insult in an animal model are being studied. Currently, primary schizophrenia: TMT-based quantitative proteomics study: The cultures of motor neurons, astrocytes, microglia, olfactory bulb; cell researchers identified a total of 5,387 proteins, of which 499 lines of motor neurons (NSC-34), Dopaminergic neurons (N27), proteins were differentially expressed in schizophrenic anterior Neuroblastoma (SHSY5Y) and glioblastoma (U251MG, U87MG) cingulate cortex, frontal cortex, hippocampus and thalamus and human embryonic Human Embryonic Stem Cells (BJNhem20) when compared against non-schizophrenic. The comparison are grown in this laboratory. Several funded projects are being executed of the data with the Plasma Proteome Database resulted in in this laboratory. Research scholars (PhD and MPhil Scholars as well mapping of 3,752 proteins. The analysis revealed significant as DM neurology residents) from other departments of the institute protein expression changes across the 4 tissues. and several external trainees are utilizing the available facilities. ix) Proteomic analysis of codeleted and non-codeleted Completed research activities: oligodendroglioma tissue samples: In order to comprehend 1. The effect of the most prominently up-regulated protein the effects of the deletions on cellular proteome and identify in ALS-CSF, namely Chitotriosidase (CHIT), on glia and differentially expressed proteins, a TMT based quantitative neurons was investigated. Supplementation of CHIT to culture profiling of glioma tissue from codeleted and non-codeleted medium did not reduce the viability of NSC-34 cells. However, samples was carried out. It resulted in identification of 4,019 intrathecal administration of CHIT to neonatal rats increased proteins. Of these, 39 were found to be over-expressed and the number of Iba1 positive microglial cells and astrocytosis in 45 were found to be down-regulated in codeleted samples as both white and grey matter of the ventral horn of spinal cord. compared to non-codeleted samples. The numbers of ChAT positive motor neuronal cells were also reduced. The studies suggest CHIT can induce glial activation, x) Proteome profiling of hippocampus, amygdale and olfactory resulting in neuroinflammation, which accentuates degeneration bulb from adult human male: This analysis is part of the human of motor neurons. Thus, the researchers hypothesize that brain proteome map study. The researchers have identified neuroinflammation might be one of the primary events that 7,300, 6,755 and 5,996 proteins from hippocampus, amygdale leads to the motor neuron degeneration and thus could be and olfactory bulb respectively. considered as a potential target for therapeutic intervention.
Ongoing research activities: 2. Mitochondrial dysfunction in sporadic models of ALS was i. Comparative proteomic analysis of serum and cerebrospinal investigated. Quantitative proteomic analysis of the sub- fluid of Guillain-Barre syndrome and paralytic rabies cellular fractions of spinal cord dissected out from the sALS model revealed down-regulation of mitochondrial proteins ii. Comparative phosphoproteomics analysis of mitochondria which contribute to alterations in respiratory chain complexes isolated from muscle samples of dystrophenopathy, distal and organellar morphology. The enzyme activities of electron myopathy with rimmed vacuoles, inflammatory myopathy and transport complexes were also reduced. Down-regulated control individuals lysosomal proteins Hexosaminidase, Sialidase and Aryl sulfatase also displayed lowered enzyme activity. sALS-CSF also induced iii. A proteomic map and functional annotation of the normal the over-expression of the pro-apoptotic mitochondrial human olfactory epithelium protein BNIP3L in rat spinal cord. In cultured motor neurons,
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sALS-CSF induced neurotoxicity, lowered mitochondrial GFAP/ Tuj1/Olig2 and the images were captured using membrane potential and elevated ROS. These observations confocal laser scanning microscopy. The standardized protocol indicate the first line evidence that sALS-CSF mediated will be followed and the cells will be used for quantitative PCR, mitochondrial and lysosomal defects collectively contribute to immunocytochemistry and electrophysiology. the pathogenesis underlying sporadic ALS. Electrophysiology Laboratory (Officer In-charge: Dr. BS 3. The effect of ALS-CSF exposure on TDP-43 and Shankaranarayana Rao) FUS expression in NSC-34 cells were investigated by immunostaining and calculating N/C ratio of fluorescence The electrophysiology laboratory is engaged in evaluating the synaptic intensities to specifically study the mislocalization. Following plasticity mechanisms in various animal models of neurological and conclusions can be drawn from this study: psychiatric disorders. Activity-dependent synaptic modulation and ALS-CSF induces overexpression of TDP-43 and FUS information processing in live brain slices of the hippocampus and proteins in cytoplasmic compartment of NSC-34 cells, medial prefrontal cortex are being studied. The researchers are also suggesting mislocalization of these proteins. studying plasticity mechanisms in the hippocampus, cortex and ALS-CSF exposure also induced cytoplasmic aggregation amygdala in animal models of stress, anxiety, depression and epilepsy. of TDP-43 and FUS proteins. Several strategies to restore cognitive deficits and abnormal synaptic VEGF supplementation partially reverses this plasticity in the above mentioned disease conditions by rewiring and mislocalization. remodelling of neural circuits including pharmacological and non- pharmacological approaches have been developed. In addition, the Ongoing research activities: researchers have used microelectrode array technology for in vitro 1. Glial responses in sporadic models of ALS were studied. recording of electrophysiological activity of neurons. The researchers found down regulation of trophic factors VEGF and GDNF, while pro-inflammatory markers like IL6, Completed research activities: TNF-α, PGE-2 and COX-2 were significantly upregulated in Researchers in this laboratory have studied (i) the effect of microglial cultures exposed to ALS-CSF, as early as 48hours. inactivation of amygdala in amelioration of stress-induced Simultaneously, glutamate levels were also elevated. The cognitive deficits by restoring abnormal synaptic plasticity in the investigations on protein levels in microglia and protein as well hippocampus and prefrontal cortex, (ii) role of chronic exposure to as m-RNA levels in astrocytes depict a significant regulation of enriched environment and antidepressants treatment on restoration VEGF and GDNF in both the cells. These findings support the of hippocampal structural and functional plasticity in endogenous theory of accentuated neuroinflammation in ALS as an early animal model of depression, (iii) the cellular and molecular event in the disease pathogenesis. Further investigations on the basis of temporal lobe epilepsy-induced cognitive deficits and synergism of glia and neurons can lead to better understanding abnormal synaptic plasticity, (iv), role of enriched environment and of the disease pathogenesis, and identification of possible antidepressants on depression-induced cognitive deficits and (v) therapeutic targets. and protective effect of chronic treatment with Celastrus paniculatus Willd oil on stress-induced cognitive impairments and diminished 2. The aim of this study is to differentiate Human Embryonic hippocampal synaptic plasticity. Stem Cells BJNhem20 into spinal motor neurons, characterize them and use as a cellular model for sporadic ALS. BJNhem20 Ongoing research activities: was obtained from Jawaharlal Nehru Centre for Advanced Researchers in this laboratory are currently focusing on (i) studying Scientific Research ( JNCASR) and the cell line was established the cellular and molecular basis of endogenous depression induced in this lab. The stem cells were grown on mitotically inactivated abnormal synaptic plasticity in the hippocampus interms of evaluating mouse embryonic fibroblast feeder layers. Cells were passaged altered long-term potentiation (LTP) and long-term depression using accutase and cryopreserved in liquid nitrogen for future (LTD), (ii) evaluation of antiepileptic activity of both crude and use. The protocol for motor neuron differentiation was initiated active components of medicinal plants namely, Eclipta alba and by pelleting the ES colonies and transferring them to a low Pistacia integerrima, (iii) the cellular and electrophysiological basis of adherent culture dish with the embryonic stem cell medium restoration of stress-induced cognitive deficits and altered synaptic without bFGF. Retinoic acid and purmorphamine were used plasticity by chronic treatment with Celestrus paniculatus, (iv) the for motor neuron derivation. Phase contrast images were taken synergestic action of short-duration enriched environment with sub- for understanding the morphological changes through the effective doses of antidepressant treatment on depression induced differentiation protocol. Immunocytochemistry was performed cognitive deficits, (v) role of enriched environment and antidepressants with cells at different stages using antibodies to Oct4/Nestin/ on chronic stress-induced depression and cognitive deficits, (vi)
National Institute of Mental Health and Neuro Sciences 115| Annual Report 2014-15 modulation of amygdalar activity and its impact on stress-induced observed that pharmacological inhibition of mitochondrial Ca2+ cortical plasticity, (vi) evaluating the role of enriched environment and load in neurons lead to protection of mitochondrial function antiepileptic drugs on epilepsy-induced abnormal electric activity on and cell survival. the hippocampus, cortex and amygdala, and (vii) effect of modulation of glutamatergic transmission and brain stimulation rewarding iii. To understand the molecular mechanisms of neuropathic pain experience on anxiety and depression. the signaling events in sensory neurons were monitored by live cell Ca2+ imaging and patch clamp recording in spinal cord slices. Optical Imaging Lab (Officer In-charge: Dr. Preeti Joshi) Effect of some known drugs viz. gabapentin and duloxetine on the activity of sensory neurons was studied. It was observed that This laboratory is an advanced facility for conducting sophisticated acute treatment of slices with gabapentin or duloxetine inhibits experiments such as real time recording of signalling events in cells the frequency of action potentials in sensory neurons and also and tissue. The laboratory is equipped with confocal microscope, inhibits glutamate induced Ca2+ signals. Further experiments epifluorescence systems for imaging and patch clamp setup for are in progress to elucidate the mechanism of action of these electrical recording from cells. These state-of-the-art techniques are drugs. being used by the researchers to unravel the cellular and molecular basis of physiological and pathological signalling in the nervous iv. Some of the projects in this lab are in collaboration with system. The long-term objective of the research is to identify the department of Neurology and department of Psychiatry. A defective signalling modules and its origin at molecular level (ion new project on understanding the mechanisms of neuropathic channels/receptors etc.) in neuro-psychiatric disorders. This can pain and exploring new therapeutic targets was initiated in be translated into targeted therapy by developing drugs against the collaboration with Bristol Myers Squibb Company (BMS) identified molecular targets. USA and Biocon Bristol- Myers Squibb R & D Centre Bangalore. The research projects for this laboratory are funded Completed research activities: by DBT and BMS. To understand the mechanism of ATP induced pain /hyperalgesis studies were performed on DRG neurons in culture. Purinergic Neuromuscular Laboratory (Officer In-charge: Dr. AB Taly) receptors activated by ATP and its analogs were characterized in DRG neurons. The Signaling events induced by ATP and capsaicin The Neuromuscular Laboratory, in keeping with its mandate, provides were studied. A novel receptorin DRG neurons exhibiting atypical advanced diagnostics and promotes active research in neuromuscular biophysical characteristics was identified. disorders. During the review period, an advanced diagnostic facility for immune mediated disorders and muscle disorders was successfully Ongoing research activities: initiated on a self-sustaining mode with seed grant from NIMHANS i. Researchers in this laboratory are currently focusing on the with the objective of making available expensive, labour intensive role of glial cells in epilepsy, intra and inter-cellular signaling sophisticated tests to patients admitted at NIMHANS as well as aberrations in neuropsychiatric disorders and pain sensation. other hospitals in and around Bangalore. Availability of these tests Regulation of Ca2+ signaling was studied in lymphoblasts has greatly benefited patients and assisted in diagnosis, and timely derived from dementia patients carrying different alleles of institution of therapy. ApoE gene and control groups. The researchers have found significant differences in the cellular Ca2+ signaling profile There are several ongoing projects in neuromuscular disorders between control and dementia groups. The ability of cells to funded by grants from DBT, DST and ICMR. The results have been release Ca2+ from intracellular stores upon stimulation appears presented in national and international conferences by faculty and to have altered in dementia group as compared to normal students. The research work has been translated into 15 publications control group. in peer-reviewed National and International journals and two best paper awards have been received. ii. To understand the pathogenesis and progression of motor neuron degeneration in amyotrophic lateral sclerosis (ALS), Completed research activities: the effects of ALS-CSF on cellular signaling in spinal cord 1. Establishment of skin punch biopsy for evaluation of peripheral neurons was studied. It was observed that exposure of spinal neuropathies (DBT funded) cord cultures to ALS-CSF severely affects the mitochondrial morphology and function. These effects were observed 2. Protein Aggregate myopathies - A clinical, Pathological, specifically in motor neurons whereas the neighbouring other immunohistochemical, molecular genetics and proteomic spinal neurons were largely unaffected. The researchers also investigation (DST Funded)
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Ongoing research activities: (iii) Analysis of natural products and their derivatives in experimental 1. Respiratory chain disorders in children-Genotypic, phenotypic models of Parkinson’s diseases. and functional correlation. (iv) Analysis of transcriptomic and epigenetic mechanisms 2. Spectrum of Autoantibody expression in Generalized associated with 3-nitropropionic acid neurotoxicity. Myasthenia gravis: Clinical Phenotype and Immunological Correlation( NIMHANS Intramural Grant) (v) Comparison of Manganese and MPTP toxicity: Implication for movement disorders. 3. PLA2G6 - Associated Neurodegeneration: A Phenotypic and Genotypic study (Non-Funded) Patient care services: The laboratory contributes to the five mitochondrial assays and five 4. Paediatric Anti-NMDAR Encephalitis: A Clinical, Electro- western-blots based diagnostic tests, carried out by the Neuromuscular encephalographic and Follow-up Study (Non-Funded) Laboratory.
Patient care services Cognitive Psychology & Cognitive Neurosciences Laboratory The laboratory has started two new services. Autoimmune tests (Officer In-charge: Dr. Mahendra P. Sharma, Professor and Head, that include ANA + myositis profile, ANCA, NMO (aquaporin 4 Department of Clinical Psychology) antibodies); encephalitis mosaic (NMDA and VGKC complex) and paraneoplastic neuronal antibodies have been introduced. The focus of this laboratory is to carryout research in neuromusicology and music cognition. The research work aims to examine the neural Western blots for diagnosis of limb girdle muscular dystrophies and correlates and cognitive processes involved in music perception, respiratory complexes assays for mitochondrial disorders have also production and cognition from both basic science approach and been initiated. application of the findings to clinical set up.
The research staff of Neuromuscular Laboratory has assisted Completed research activities: the Department of Neuropathology by performing muscle The effect of north Indian classical music (NICM) on perception immunohistochemistry for muscular dystrophies in 291 cases. of pain and anxiety, stress measured by levels of cortisol heart rate variability, blood pressure, as well as dosage of sedative drugs and Neurotoxicology Laboratory (Officer In-charge: Dr. Srinivas depth of anesthesia in patients undergoing spinal surgery was Bharath) examined. In this double blind randomized controlled study the sample included 62 patients undergoing spinal surgery (n=30 in The Neurotoxicology Laboratory focuses on investigating the music and n=32 in the non-music group). There was a significant mechanistic and therapeutic aspects of neurotoxic models with decrease in the perception of anxiety in the music group on self- implications for degenerative diseases. The laboratory employs report using a visual analogue scale as well as on the state trait biochemical, proteomic and epigenetic methods to understand the anxiety inventory(p<0.05). There was significant difference between toxicological basis of disease and the role of oxidative stress and the two groups in the cortisol levels and dosage of anesthetic drug mitochondrial damage in neurotoxicity. dosage consumption in both the groups between pre-surgery and post-surgery evaluation. Future studies will be aimed to examine the Ongoing research activities: effect of self-chosen music as well as other neurochemical parameters (i) Analysis of the epigenetic regulation of red/ox mechanisms in which will measure the effect of intervention (Funding agency- neurotoxic models of Parkinson’s disease involving investigation NIMHANS, intramural research grant. PI: Dr. Shantala Hegde, of the role of chromatin modifications. Assistant Professor, Department of Clinical Psychology, CO-PI: Dr. G.S. Umamaheswara Rao, Senior Professor, Department of (ii) Neuroprotective effects of nanoassisted C60-pyrimidine Neuronaesthesia and Dr. Rita Christopher, Professor, Department derivatives in neurotoxic models of Parkinson’s disease. of Neurochemistry, NIMHANS).
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New Self-Sustaining Diagnostic Facility
There is a pressing need to upgrade diagnostic facilities and optimize patient management is in the areas of neuromuscular disorders, molecular diagnostics for neuroinfections and prognostic markers for brain tumors. Over the last decade, several new validated tests with enhanced sensitivity and specificity have been developed that provide high precision in clinical diagnosis and directs accurate treatment. Early detection has tremendous impact on management and economizing additional investigations and direct specific therapy, thereby also reducing hospital stay. Most of these tests are unavailable or expensive and unaffordable to our patient clientele who are from middle and lower socioeconomic status.
In the last year, as a new initiative, an advanced diagnostic facility has been successfully initiated in the Neurobiology Research centre with seed grant from NIMHANS. This facility has been initiated on a self-sustaining mode with the objective of making available advanced labour intensive sophisticated tests available to patients admitted at NIMHANS at affordable price as well as other hospitals in and around Bangalore.
The tests are offered in the following laboratories
1. Neurooncology Laboratory: FISH (Fluorescent insitu hybridization) for 1p19q co-deletion and MGMT methylation that serve as prognostic biomarkers for oligodendrogliomas & Glioblastoma respectively (to guide adjuvant therapy).
2. Neuromuscular Laboratory (Autoimmune disorders): ANA profile and ANCA (for systemic vasculitis); NMO/Aquaporin 4 antibodies for Neuromyelitis optica; NMDA and VGKC receptor antibodies for diagnosis of autoimmune encephalitis; and paraneoplastic antineuronal antibodies panel.
3. Neuromuscular Laboratory (Muscle disorders): Western blot for calpain, dysferlin, alpha dystroglycan, telethonin for diagnosis of limb girdle muscular dystrophies and mitochondrial complex assays for diagnosis of mitochondrial disorders.
4. Molecular Biology Laboratory (Communicable): PCR testing for HSV1&2, VZV, JCV, CMV, JE, Rabies, Enterovirus, Dengue, Chikungunya, H1N1, etc; Acute encephalitis syndrome (AES) & Septicemia chip for molecular diagnosis of CNS infections.
5. Molecular Genetics Laboratory: Genetic testing for Duchenne/Beckers muscular dystrophy, spinal muscular atrophy.
Availability of these tests has greatly benefited patient care by assisting in accurate diagnosis, therapeutic decision making and timely institution of therapy in addition to supporting research and publications. More information regarding these labs is available on the NIMHANS website.
The Virtual Department of Clinical Dr. Ravi Yadav, Associate Professor of Neurology. The department Neurosciences currently has 25 PhD scholars (5 candidates per year) who are selected and provided financial support under the Indian Council of Medical Research (ICMR) Talent Search Scheme (TSS). The Virtual Department of Clinical Neurosciences has been created to foster research temperament amongst medical graduates with Five candidates who have completed MBBS with brilliant academic brilliant academic records. The long-term objective of creation of the records are selected each year on the basis of a competitive national- discipline of Clinical neurosciences is to boost capacity at the national level entrance examination and personal interview, conducted along level in the emerging field of Translational Medicine, specifically as it with the annual entrance examinations for all courses at NIMHANS. applies to Neuroscience. The Institute envisages that the newly set-up Five students of the 2014 batch – Dr. Ragasudha, Dr. Sravya, Dr. department would succeed in bringing out clinician-neuroscientists, Kiran, Dr. Nikhil and Dr. Albert – are undergoing training in various who are equally adept in both clinical and research aspects, unlike clinical neurosciences departments. the dichotomy that seems to exist at present. This new enterprise, therefore expects to bridge the wide gap that exists between the “bench and the bed-side”, thereby leading to translational research that will have more direct clinical applications. Nimhans Centre For Well Being
The department has three adjunct faculty members: Prof. Vani NIMHANS Centre for Well Being (NCWB), an urban community Santosh, Professor of Neuropathology (as head of the virtual centre, aims at working on preventive and promotive aspects of mental department), Dr. John P. John, Additional Professor of Psychiatry and health. The centre offers clinical services and organizes various training
118 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 and outreach programs. The clinical services include psychological NCWB brought out one information booklet on Child sexual interventions and psychiatric help for minor mental health issues. abuse in Kannada titled ‘Namage kelisikolluva reethi gotthidhare maathra!’ Faculty members from Psychiatry and Clinical Psychology During the year under review, interactive workshops (40 at departments associated with the centre developed 5 IEC leaflets on NIMHANS and 21 outside the Institute) were conducted for various mental health related topics. groups – students, parents, teachers, elderly, general public, mental health professionals and medical professionals—on topics related to The centre in collaboration with White Swan Foundation launched mental health promotion and prevention. Mental health education a new website for suicide prevention -Gatekeepersindia.org, on the programmes were organised for Anganwadi children (Health Talk event of world suicide prevention day, 10 September 2014. on Importance of Handwashing, Demonstration of Handwashing, As part of the International Women’s Day celebrations, NCWB Health Talk on Importance of Personal Hygiene at Anganwadi by distributed about 200 toolkits for Health Settings on ‘First level Mrs. D Padmavathy & Team), adolescent girls and teachers of a few Psychological Intervention for women survivors of intimate partner government schools, and young mothers in Primary Health Centre violence’ on 20 March 2015. (Health Education on Importance of Balanced Diet in Antenatal period, Health Education on Importance of Breast Self-Examination, On account of World Suicide Prevention Day 2014, a press meet was Health Education on Postpartum Psychosis, Health Education on organized by the centre at the Director’s Office, NIMHANS where Postnatal Nutrition, Health education on Somatoform disorder: journalists from leading media organisations participated. The faculty Screening for Somatization, Health Education on How can I Protect associated with the centre contributed six articles related to suicide myself from H1N1 at Tavarekere Primary Health Centre by Mrs. D prevention in leading news dailies namely Prajavani and Deccan Herald. Padmavathy & Team).
The centre has started a new clinic for youth: Window to Well Centre For Public Health Being—A clinic for the Youth. This clinic provides interventions for various difficulties faced by youth including stress related to academics, The Centre for Public Health (CPH), established at NIMHANS relationships, emotional problems (depression, anxiety, adjustment in November 2012, provides inputs for strengthening public health problems, etc.), self-esteem issues, self-harming behaviors, suicidal response to Mental, Neurological, and Substance Use Disorders, thoughts or acts, etc. The team in the clinic liaises with the parents Injuries and other Non-Communicable Diseases. The main areas to improve their relationships and bridge the generation gap with of work include human resource development, strengthening public youth. The clinic also provides training for counselors and teachers health research, policies, programmes and advocacy. Government working with youth in understanding about psychological problems of Karnataka (vide ltr N.HFW30CGE 2013 dated 30/1/2013) and building their skills. recognized the district of Kolar as the public health observatory under the CPH. An additional floor constructed at the NCWB building was inaugurated by Dr. P. Satishchandra, the Director/Vice-Chancellor of The formal launch of the activities under the Public Health NIMHANS on 23 April 2014. The first floor houses ‘Mindspace’, a Observatory was held on 10 October 2014 with Shri. UT Khader, space for academic programs and workshops and ‘Knowledge Nook’, Honorable Minister for Health and Family Welfare, Government of a library and information space for mental health and preventive Karnataka, as the Chief Guest. The programme was presided over neurology that is open to general public. by Shri. Renuka Prasad, Chief Judicial Magistrate, Kolar District. Several key persons including elected representatives and district Publications and other IEC materials administration officers participated in this public function. During the event, the four status baseline reports for the District (District ‘The Loudspeaker – Amplifying the voice of mental health’, a mental Mental Health Systems, Health Resources, Health Management health magazine for general public was launched by NCWB on Information System and Information Education Communication 30 December 2014 at an event organised to observe ‘International Reports) were released. Day of Persons with Disabilities’. Chief Guest of the event Smt. Meera C Saksena, Acting Chairperson, Karnataka State Human A walkathon, flagged off by the Deputy Commissioner (Late) Shri. Rights Commission, released the first issue of the magazine on the DK Ravi, to spread mental health awareness among the community occasion. ‘The Loudspeaker’ is a quarterly magazine packed with was organized and about 5000 mental health education pamphlets up-to-date and cutting edge features on mental health care. Printing were distributed to general public on the occasion. Sensitization and publishing of the magazine is funded by Dr. Ramachandra N programme on mental health issues among school children was also Moorthy Foundation for Mental Health and Neurological Sciences. conducted for 40 teachers in Kolar district.
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In accordance with its mandate, during the year, several operational the inspection was sent to Govt. of India, Ministry of Environment research activities were undertaken in the public health sphere areas of and Forests, Animal Welfare division-CPCSEA on 18 December Road Traffic Injuries, Harms to Others from Alcohol use, Drugs and 2014. This report is mandatory for renewal of license to conduct Logistics and development of a manual for training of Community animal experiments at the Institute. health personnel. To improve service delivery for mental, behavioural and substance use disorders the training of health personnel was The facility has been upgraded with Intravital Fluorescent undertaken. Microscope, which will be used to make observations and acquire in-vivo measurements, to assess biologic relevance in an intact During the review period, Medical Officers from various Primary physiological environment in living animals. This technique allows Health Centres in the district were trained and a new training investigation of vascular microcirculation of a number of tissues programme for Community Health Workers has been initiated. including tumors. Studies on physiology and pathophysiology in Focused initiatives were undertaken with respect to assessment of live animals, blood circulation into the brain, leukocyte-endothelial industrial health systems and services within the district. interactions, macrophage function, and lymphatic circulation studies can now be carried out. ‘Yuva Spandana’ project aimed at providing health promotion services for youth anchored by District Youth empowerment centers was taken Functions of CARF up in 10 districts of Karnataka. Around 142 sensitization programmes reaching 14,000 youth spread across 10 districts was conducted. CARF supplied research team with timed pregnant animals, and neonatal animals for preparation of cell lines. Experiments on spinal cord allograft, studies on Electro Convulsive Therapy (ECT), behavior studies, specialized enrichment experiments were carried out, and assistance for experimental surgery were also provided.
Apart from timely supply of required age, sex and weight of each strain of animal, necessary support was provided to studies on: Effect of pentoxyphylline on microvascular flow pattern in experimental cerebral vasospasm model; Behavioral studies of spatial vs non-spatial learning in ventral subicular lesioned rats, cellular and molecular basis of epilepsy-induced cognitive deficits; Tau-focused immunotherapeutic approaches to Alzheimer’s disease, and rabies diagnostic virology. The
Walkathon to spread mental health awareness in Kolar flagged off by Shri. DK CARF has a biorhythm facility. Ravi, DC, Kolar In addition to the above mentioned activities, the CARF also guided and assisted researchers in designing and planning of protocols, and in Central Animal Research Facility day-to-day care of animals (husbandry).
The Central Animal Research Facility (CARF) was started in the The CARF maintains good standards in husbandry practices, uses year 1979 for pursuing and conducting research and training in laboratory animals for research responsibly and is deeply committed neurobiological sciences. At CARF adequate care is taken to follow to the principle of 3 R’s: Reduction, Replacement and Refinement of rules and regulations, and humane care of laboratory animals, as use of animal for research. proposed by the Ministry of Social Justice and Empowerment, Government of India, the Committee for the Purpose of Control During the year 2014-15, the CARF housed and maintained a total of and Supervision of Experiments on Animals and the Breeding of and 78,786 animals (mice: 20,912; rats: 57,360, rabbits: 274, guinea pigs: Experiments on Animals (Control and Supervision) Rules 1998 and 240) 2001. Teaching - Training Programme CARF is one of the few lab animal facilities in the country for which CPCSEA has granted license to ‘Education, Breeding and Research’. CARF was also involved in manpower development activities CARF was inspected by a team from Committee for the Purpose of including organizing IAEC meetings and conducting training Control and Supervision of Experiments on Animals (CPCSEA) programmes. A total of 42 students and researchers from NIMHANS headed by Dr. MR Gajendragad on 12 December 2014. A report on (18), as well as from outside institutes (11 from National Institute of
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Unani Medicine, Bangalore and 13 private candidates), attended the Celltrion, Korea for their neutralizing capacity against 6 Indian course on Care, Breeding and Management of Laboratory Animals— street rabies viruses. out of which 36 were successful in completing the course. 2. Development and Evaluation of Direct Rapid Institutional Animal Ethics Committee Immunohistochemical Test (dRIT) for rapid diagnosis of rabies in animals and humans. During the year, the Institutional Animal Ethics Committee (IAEC) met four times and a total of 41 research projects (19 new and 22 3. Studying the immune mechanisms involved in the natural renewal projects) were placed before the IAEC for consideration to resistance to rabies in animals. conduct research using animals. Four new projects have been referred to Institutional Biosafety committee (IBC) for screening and approval. Following is the list of new projects approved in the year 2014 - 15 Biomedical Engineering by the IAEC for which CARF has extended its facility: Biomedical Engineering Department performs the dual function of Clinical Engineering and Biomedical Engineering. Neurophysiology 1. Translational research in amyotrophic lateral sclerosis (ALS) - The department provides technology management and equipment development of biomarkers for diagnosis, monitoring disease planning support, and medical equipment maintenance of the progression and evaluation of toxicity. Pathophysiology Institute’s facilities. It focuses on improving patient care through of Skeletal muscle in Amyotrophic Lateral Sclerosis- An maximizing operational availability of technology, minimizing risk to experimental study in a rat model. patients, visitors, and care providers.
2. Spontaneous recurrent seizures induced cellular plasticity in the Major functions of the Department include: designing and hippocampus and cortex. development of hardware and software instruments to support research and clinical programmes; designing biosensors and 3. Functional Impairment of motor neurons in a rat model of biomedical instrumentation systems to detect, record and analyze Sporadic Amyotrophic Lateral Sclerosis (SALS). physiological functions; repairing and servicing of medical and analytical instruments, electrical, mechanical and electromechanical 4. Prenatal exposure of Valproic Acid in rats: Effect on sleep instruments, computer software and hardware—and their preventive architecture. maintenance; offering consultation for research and clinical specialties and recommending solutions to instrumentation and electrical safety 5. Evaluation of normal glial profile of adult C57Bl/6 and CD1 problems. The department carried out inspection of all equipment for White mice. condemnation, storage and disposing (of unserviceable items).
6. Restoration of stress-induced cognitive deficits and cortical Data Centre dysfunctions through amygdalar modulation. NIMHANS has setup a data centre to accommodate different facilities required to run various hospital applications smoothly. Biophysics This data centre is equipped with more than 19 servers, storage 1. Development of an in vitro model to assess the role of infrastructure and high speed network connectivity. Now more than endogenous astrocytes and adult stem cell-derived supportive five applications, related to different areas like project, salary, etc. are cells on the survival of midbrain dopaminergic neurons. running successfully from this data centre. New-generation-higher- end network devices like firewall, layer-3 switches are also included. Neurosurgery 1. “Feasibility of use of Tissue PatchduralTM in rat peripheral One new mini data centre using very advanced integrated infrastructure nerve repair.” is almost ready. This will act as a near Disaster Recovery (DR) centre. Both these data centres are connected by 10gbs links incorporating Human Genetics high redundancy feature. 1. Effect of aluminium on the p53 gene expression in mouse brain. The power and cooling infrastructure has also been upgraded by Neurovirology installation of additional high capacity generators, precision AC units 1. Testing of 5 human monoclonal antibodies produced by and UPS.
National Institute of Mental Health and Neuro Sciences 121| Annual Report 2014-15
The implementation of upgraded storage infrastructure with DR Engineering by using storage-to-storage replicas is in progress. Virtualization environment for hosting application with site recovery feature will be The Engineering Department caters for the maintenance of enabled during the financial year 2014-15. hospital infrastructure, administrative building, staff quarters, roads, machinery and equipment like air-conditioners, lifts, generators, etc. Disaster Recovery Centre The activities are covered under plan and non-plan head of account. Disaster Recovery Centre has been set up to provide business Some of the major works completed in the year 2014-15 include: continuity and protect the critical patient data in the event of a natural disaster or other emergency that causes downtime of the Data Construction of inpatient wards building for Adolescents for the center. It is running on 10 Gbps bandwidth connectivity to critical Department of Child and Adolescent Psychiatry; construction of departments like Emergency, OPD, Neuro Center and laboratories second and third floor in the building for inpatient treatment for which are patient data intensive. women with substance use; construction of compound wall around the proposed northern campus at Kyalasanahalli, KR Puram, Bangalore; With storage-to-storage replication and virtualization technologies construction of Additional sump tank at staff hostel; installation of between sites, the DR is having very short recovery time by fire alarm system at Kabini Hostel and Neurocentre; installation of considering the Recovery Point Objective and Recovery Time wireless smoke detectors and fire alarm systems at Faculty Centre Objective as 15 minutes to make high availability of data. The DR and Emergency Block; construction of PET MR building; providing is setup with Modular Safe, a state-of-the-art technology with IP56 dual power supply to BME Dietary Section, De-addiction and and F90 standard which ensure the fire, water and dust protection in Open Psychiatry Wards; construction of security guard rooms at the a cost effective manner. entrance of Byrasandra campus quarters, etc.
NIMHANS Network Other important works which are under progress include: Construction Initial phase of network implementation has provided connection to of first floor and second floor above the ground floor of Department various departments of NIMHANS with 10G or 1G single mode of Child and Adolescent Psychiatry; construction of concrete solid fibre in redundant manner to boost the performance in accessing the block masonry compound wall along with barbed wire fencing at the entire applications across the campus. top for NIMHANS Northern campus at Kyalasanahalli, KR Puram, Bangalore; construction of bus/car garage along the BRC campus A local ring connecting Institute’s existing Data Centre with different road; Upgradation and renovation of first floor of staff hostel at building has been established for redundancy purposes. Installation NIMHANS campus; conversion of existing vacant room adjacent to of another level of network link redundancy is in process to facilitate Neuro Infection Ward into deluxe rooms on the first floor of Ashwini access to critical applications during the time of disaster through Block; modernization of water supply system at Byrasandra campus, disaster recovery setup. LMRH, OPD, etc.; construction of Sub-specialty Block in Neuro Centre; Construction of Cyclotron building; etc. New generation L3 switches have been installed in each building along with 1gbps new access switches to enhance the performance. Wireless network has also been upgraded by installing new APs along Library and Information Centre with facilities for differentiating the guest and normal users’ traffic and giving individual password to users. The Library and Information Centre continued to expand resources for the benefit of the staff and students of NIMHANS in the year. During Cyber Security the year, the major focus of the library was on accelerating online access NIMHANS has taken necessary security protection for network, to the latest medical and health information resources in the field of servers, applications and client systems by using network firewalls, mental health and neurosciences. Equipping the library with wireless Intrusion Detection Systems/Intrusion Prevention Systems, access and establishment of advanced photocopying facility were the Application Firewalls, etc. Putting servers in DMZ zone, other major initiatives. A large number of external users visited the implementing client-server antivirus infrastructure, restructuring library for their reference work and there was an increase in the number of the network, log analysis, security incident monitoring, etc. have of requests for literature search as well. The availability of e-resources ensured better protection. of the library, including full-text databases, through a high bandwidth (1 GB) network from the NIC National Knowledge Network at nearly Web Services 2000 access points in the campus was ensured. The process of providing The new website of the Institute is hosted in the data centre along off campus access to e-resources of the library to NIMHANS staff and with additional online features like new-patient registration system. students has been completed and standardized.
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Subscription and acquisitions medical library consortia, access to information, material available for The library subscribed to a large number of journals, books and medical professionals, among others. databases. The journals and books included both print and electronic resources. The special acquisition during the year under review was the e-Thieme Neurosurgery package. Electronic journals subscribed Publication Department during the year include: APA - PsycArticles (Through Proquest; 108); Elsevier Science-Direct Neuroscience Collection (133); Elsevier The Department of Publication continued to provide an efficient Health/ Clinics (14); Karger Collection (22); Nature Group Collection system for disseminating knowledge about mental health and (14); Ovid Collection (26); Psychiatry Online Collection (4); Sage neurosciences through various specialised services and other important Collection (7); Society/Single Journals (31); Springer Collection activities during the review period. It facilitated publication of books, (10); Taylor and Francis Collection (186); Thieme e-Neurosurgery teaching manuals, technical reports and other important documents Collection (3);Wiley-Blackwell Collection (40); Sage Neurology and for academic and administrative purposes. Mental Health Collection (54); Society/ Single Journals (23); Ebsco – Psychology and Behavioural Sciences Collection (539); Proquest – Manuals/Handbooks/Scientific publications: The department Health and Medical Complete (2702); Proquest – Nursing and Allied undertook copyediting and proofreading—and coordinating the Source (306, unique titles not covered under Proquest – Health and printing—of the following publications: Stress Management for Medical Complete). E-books subscribed include: Springer Behavioural College Students and Parents (Manual); Living with Motor Neuron Science Collection 2012 – 2015 (378); Psychiatry Online--API/ Disease (MND)/ Amyotrophic Lateral Sclerosis (ALS): A Manual American Psychiatry Publishing (22); Thieme e-Neurosurgery (144). for Patients and their Caregivers; Feeling Good and Doing Well (Trainer’s Manual); Engage to Change: Youth Engagement Program Other library online bibliographic databases subscribed are APA (Facilitator’s Manual); and Kannada version of Effective Caregiving – PsycArticles; APA – PsycBooks; APA – PsycCritiques; APA in Dementia. PsycExtra; APA – PsycInfo; APA – PsycTests; Ebsco - Psycholoy and Behavioural Sciences; Elsevier ScienceDirect (Full-Text); ProQuest Institute Reports: The Annual Report 2013-14 (both in English and Health and Medical Complete; Proquest Nursing and Allied Source; Hindi) was brought out by the department, under the aegis of the Co- Thieme e-Neurosurgery. ordinating Committee formed by the Director. The Institute Activity Reports—which present comprehensive information of the Institute’s American Medical Association (3); Elsevier (28; also available online); activities, developments and achievements—were also provided for Karger (2; also available online) are the print journals subscribed. Governing Body and Academic Committee Meetings held in the period under review. A total of 393 books were added to the collection, during the year. Information Materials: Copyediting/proofreading of leaflets, flyers, Usage statistics of library resources prospectus and other vital information materials were carried out. The resources available at the library were extensively made use of by Printing and publishing of Convocation materials were also handled the staff and students of the institute as well as by professionals and by the department. students from outside institutions. The usage pattern of the library resources in the year under report is shown below: Language Classes: The department organised Kannada classes in association with the Kannada and Culture Department, Government Books and journals circulated 5334 of Karnataka, for the benefit of non-Kannada speaking faculty and No. of pages of photocopying 15065 staff. English classes for BSc Nursing (I year) students were also Number of internal users of the library 1483 coordinated by the Department. Number of external users of the library 5570 Literature search 180 Website: Relevant contents for various sections of the About Us and Number of cyber hall user 1668 Patient Care pages of the revamped website of the Institute were Full text article downloaded from subscribed e-resources 174000 contributed by the department.
Visits abroad Other Activities: Certificates for consent forms (to be presented Dr. M Jayaram participated in the Consultative Committee Meeting to the Ethics Committee) of various research activities were issued of the Medical Library Association held at Colombo, Sri Lanka after comparing/checking the veracity and correctness of the from 25-27 May 2014. This three-day meeting was attended by translated forms with the original version(s). Publications storage and 32 participants from SAARC countries. Issues discussed included inventory management, translation of notices and vital administrative
National Institute of Mental Health and Neuro Sciences 123| Annual Report 2014-15 communications into regional language, coordinating translation Celebrations and certificates (of attendance) to the participants of the works with the Institute of Translation Studies, checking name Hindi Workshop 2014 were distributed on the occasion. boards/signboards, rubber stamps, etc. were the other activities carried out on a regular basis. Nimhans Gymkhana HINDI CELL The NIMHANS Gymkhana is a recreational and sports facility Hindi Cell, functioning under the Publication Department, provided exclusively to the staff, students and their families. Situated undertook various activities under the guidance of the Department on Byrasandra campus of NIMHANS, Gymkhana has been built in of Official Language, Union Ministry of Health and Family Welfare, an area of 2,535 sqm with a plinth area of 10,320 sqm. The Director/ Government of India with a view to ensure compliance with the Vice-Chancellor, NIMHANS is the President of Gymkhana and Official Language Implementation policies and Constitutional Registrar, NIMHANS is the Vice-President. All the activities are provisions, and to promote progressive use of Hindi for the official monitored by the Executive Committee headed by a nominated purposes. Chairman. The Executive Committee has representations from all categories of staff, apart from student representatives. Translation Activities: Consent forms for research/academic activities, tender notifications, and other important correspondences The Gymkhana has the state-of-the-art facilities and equipment for were translated into Hindi, on a regular basis. sports, physical activities and recreation. It has multiple facilities for various indoor games like badminton, table tennis, carom, chess and Correspondence in Hindi: Letters to offices of the Central basketball. It also has men and women gymnasium wings, library, crèche, Government, located in regions ‘A’, ‘B’ and ‘C’, as classified by the locker rooms, utility/yoga room, amphitheater, and community hall. Ministry, were issued in Hindi to the extent possible. Official documents pertaining to the Ministry were being signed by the During the year 2014-15, indoor/outdoor sports and cultural Director and Registrar in Hindi. competitions were held for the staff and students of NIMHANS, as part of the Institute Day celebrations. The events evoked All name boards and sign boards of the Institute have been displayed overwhelming response and saw participation from 800 participants in trilingual format (English, Hindi and Kannada). Thought for the from staff and students. Day was written in Hindi and English, every day, on the display boards at Ashwini Block and Neuro Centre for the benefit of employees/ Various sports and games were conducted for children of the staff, on hospital staff and to facilitate learning of Hindi. the occasion of Children’s Day. About 150 children participated in the events. Certificates and cash prizes were distributed to the winners on Hindi Training: Hindi course/classes (Probodh, Praveen and Pragya), Children’s Day, 14 November 2014. under the Hindi Teaching Scheme, were conducted regularly to impart training of Hindi to the employees of the Institute who do not Tree planting drive to improve green cover was initiated. The possess the working knowledge of Hindi. Hindi Typing and Hindi Director and Registrar, NIMHANS inaugurated the programme by Stenography training was also provided under the scheme. planting saplings on Gymkhana ground on 11 July 2014. A public lecture on ‘The Green House in an Urban Home’ was organized and Hindi Week Celebrations: seeds and bio-fertilizers were distributed to all the participants of the programme. Note books and merit cash prizes were distributed Hindi Week was celebrated at NIMHANS in the month of December. to 110 and 135 children/students (from 1st standard to PG courses) A three-day workshop on Unicode by Shri. Eshwar Chandra Mishra, respectively on the occasion. Assistant Director, Central Translation Bureau, and various other competitions such as essay writing, debate, noting and drafting, A new GE LED lighting system has been installed (replacing the singing, etc. were organised as part of the Hindi Week celebrations. old halogen lighting) in the badminton court to enhance visibility. The wooden floor was refurbished and the poles were repaired in the Valedictory Function of the Hindi Week Celebrations 2014 was held badminton court, during the year. Changing room was constructed at on 24 December 2014. Smt. Subbalakshmi G.R, Chief Manager, the women’s gym and the floor of the crèche was redone with vinyl Vijaya Bank (Head Office), Bengaluru was the Chief Guest. Prizes to flooring for the safety of children attending crèche, during the year the winners of various competitions held as part of the Hindi Week under review.
124 | National Institute of Mental Health and Neuro Sciences Research Activities Research Activities
2+ Biophysics the controls. There are clear indications that stimulus induced Ca release from ER differs in control and cell lines carrying apoE 3/3 and apoE3/4 genotypes. 1. Purinergic signaling in astrocytes: Implications in pathophysiology of epilepsy. DBT- National Initiative on
glial cells in Health and Disease. Investigator: Dr. Preeti G 0.30
Joshi (Funding by DBT, New Delhi) # 0.25 * It is now well established that the astrocytes are important partners of 0.20 * neurons in brain function. Recent studies also suggest that astrocytes * can also play crucial role in pathogenesis of several neuro-psychiatric 0.15 disorders including epilepsy. Purinergic receptors are key mediators GNPC515 GNPC547 in neuron-astrocyte signaling. In an in-vivo rat model of temporal 8904 0.10 8991 lobe epilepsy, the investigators have observed that induction of 8995 seizure activity causes upregulation of some metabotropic purinergic 0.05 receptor subtypes in the hippocampus. The mRNA and protein Fluorescence intensity ratio (340/380nm) ratio intensity Fluorescence levels of P2Y1 and P2Y2 receptors are significantly enhanced after 0.00 seizures. Immunostaining studies reveal that these changes occur Fig. Stimulus induced differential Ca2+ release from ER in lymphoblastoid cell only in dentate gyrus region of hippocampus. The functional activity lines isolated from control and dementia patients. of astrocytes is also altered. In status epilepticus, animal stimulation of P2Y1 receptor elicits enhanced Ca2+ signaling in astrocytes and 3. Mechanisms of action of neuropathic pain targets: concomitantly inhibits the neuronal hyperactivity. Activation of P2Y2 Electrophysiological and calcium imaging studies in spinal receptors enhances the neuronal hyperactivity. Thus astrocyte-neuron cord neurons. Investigator: Dr. Preeti G Joshi (Funding by communication is certainly altered in status epilepticus animals. Bristol Myers Sqibb Co.)
2. Calcium signaling, mitochondrial and ER function in Following nerve injury, primary sensory neurons in the dorsal root lymphoblastoid cells with different ApoE genotypes – DBT. ganglion and secondary sensory neurons in the spinal cord dorsal Investigator: Dr. Preeti G Joshi (Funding by DBT, New horn exhibit a variety of electrophysiological abnormalities, including Delhi) increased baseline sensitivity and/or hyper-excitability, which can lead to abnormal burst in activity and central sensitization that ApoE gene mutations have been associated with dementia. ApoE4 underlies pain, but the molecular basis for these changes has not allele is considered a risk factor for Alzheimer’s disease but the been fully understood. Understanding the mechanisms of action of cellular mechanisms for this association are not known. Deregulation known drugs and novel targets in neuropathic pain models is critical of intracellular signaling events is a common feature in disease in designing molecules with improved efficacy and reduced liabilities biology. Abnormalities in Ca2+ regulation in the peripheral cells in clinic and in supporting clinical development of these molecules. including lymphoblasts, lymphocytes and fibroblasts have been The glutamate induced signaling in sensory neurons was investigated reported. The investigators are studying the Ca2+signaling events in using real time Ca2+ imaging and electrophysiology in live spinal a peripheral model of a lymphoblastoid cell line and in derived cell cord slices. Experiments were carried out to elucidate the effect of lines which differ in the ApoE genotype. The Ca2+ signaling profile of some neuropathic pain suppressors on the sensory neuron signaling. lymphoblastoid cell lines (LCL) isolated from dementia patients and Glutamate stimulation caused a large inward current and elevation of 2+ controls were studied. The basal [Ca ]i levels and the signals evoked intracellular calcium concentration in dorsal horn neurons suggesting by various neurotransmitters and other activators of intracellular the presence of functional glutamate receptors. Glutamate induced Ca2+ release were measured. Blind experiments were performed on Ca2+ signal was appreciably inhibited by gabapentin. Similarly, different cell lines to avoid the bias. Results obtained so far indicate gabapentin exerted a significant inhibition in the glutamate evoked that in dementia patients the Ca2+ signaling is altered as compared to current in dorsal horn neurons.
126 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
It was also observed that the oxidative stress is arrested in other spinal neurons but continues to increase in motor neurons. Thus, the results demonstrate that upon AMPA receptor stimulation the motor neurons employ some additional pathways for regulation of mitochondrial calcium and oxidative stress as compared to other spinal neurons. It is suggested that such differential signaling mechanisms in motor neurons could be crucial for their selective vulnerability to excitotoxicity. Fig. Inhibition of glutamate induced currents by gabapentin in sensory neurons in rat spinal cord slices. 5. Rational drug discovery of potent Keap1 inhibitors. 4. Role of mitochondria in selective degeneration of motor Investigator: Dr. B Padmanabhan neurons in amyotrophic lateral sclerosis. Investigators: Dr. Preeti G Joshi, Dr. NB Joshi Neurodegeneration in humans is known to occur as a result of several primary causes, including expression of certain gene alleles, It is well established that motor neurons are highly vulnerable to toxicant administration and aging. Oxidative damage/stress (OS) glutamate induced excitotoxicity. The selective vulnerability of these has been associated with various neurodegenerative diseases (NDs) neurons has been attributed to AMPA receptor mediated excessive like Parkinson’s disease, Alzheimer and ALS. The Keap1-Nrf2-ARE rise in cytosolic calcium and consequent mitochondrial Ca2+ loading. system is a major cellular component of cell homeostasis maintenance, Earlier the investigators have reported that in motor neurons a generic which regulates transcription of a series of cytoprotective genes. The 2+ 2+ rise in [Ca ]I does not always lead to mitochondrial Ca loading expression and/or activation of Nrf2 in neurons can be strongly and membrane depolarization but it occurs upon AMPA receptor protective, and thus the Nrf2 system is a potential drug target in activation. The mechanism of such specific mitochondrial involvement NDs. In the basal condition, Nrf2 factor is negatively regulated by upon AMPA receptor activation is not known. This study examined Keap1 which helps in degradation of Nrf2 through proteasome. the mitochondrial Ca2+ regulation and oxidative stress in spinal cord Main objective of this project is to discover small molecule inhibitors neurons upon AMPA subtype of glutamate receptor activation. The for Keap1 by rational structure based approach. In this context, results demonstrated that in motor neurons the Ca2+ sequestration the investigators have performed cloning, expression, purification by mitochondria occurs through mitochondrial calcium uniporter as and crystallization experiments for the Keap1 protein. The Keap1 well as due to reversal of Na+/Ca2+ exchanger, in contrast the latter cloned into pET28a vector with His-tagged and expressed in E.coli pathway does not contribute in other spinal neurons. It was found (BL21 codon plus). Expressed protein was purified using affinity that the activation of cytoplasmic nNOS leads to ROS formation in purification and gel filtration methods. The His-tag Keap1 protein both types of spinal neurons but mitochondria is the major source of was characterized by Orbitrap mass-spectrophotometer. Initial hits of ROS in motor neurons. Spinal neurons exhibited a significant time Keap1 protein crystals have been obtained from protein crystallization dependent fall in glutathione (GSH) level. screening. The crystal screen optimization to obtain good single crystals for X-ray diffraction studies is in progress.
Fig. (A) SDS-PAGE of Keap1-DC, (B) Keap1-DC crystal
6. Drug discovery of potent inhibitors for epigenetic marker, BRD2 bromodomains by rational structure-based approach. Investigator: Dr. B Padmanabhan (Funding by DBT) Fig. AMPA induced ROS formation in spinal neurons: (A) Phase contrast and (B) fluorescence images of HEt loaded spinal cord cultures. Arrow represents Lysine acetylation levels in histones are epigenetic marks associated motor neurons (somal diameter > 20 µm) and * represents other spinal neurons (somal diameter < 20 µm). with gene activation, chromatin modification, DNA damage,
National Institute of Mental Health and Neuro Sciences 127| Annual Report 2014-15 transcription and cell-cycle control. This acetylation is reversibly protein DBC1 shows pro-apoptotic function. By inhibiting the anti- maintained by histone acetyltransferases (HAT) and histone apoptotic SIRT1, DBC1 is able to promote apoptotic pathways via deacetylases (HDAC). Bromodomains are modules conserved in p53 hyperacetylation. DBC1 binds directly to the catalytic domain of several nuclear proteins that recognize mono or di-acetylated lysine SIRT1, preventing substrate binding to SIRT1 and inhibiting SIRT1 residues. The BET (bromodomain and extraterminal domain) activity. Understanding how the interaction between DBC1 and family proteins contain two tandem bromodomains (BD1 and SIRT1 is regulated will provide in-depth details for designing strategies BD2) and a conserved extra-terminal domain. Dysfunction of BRD to increase the activity of SIRT1. Though the function of DBC1 is protein has been linked with development of several diseases. The known, the structure and its interaction mechanism with SIRT1 are BET family, BRD2 has been implicated in pathogenesis of cancer, still unknown. The DBC1 protein is of length 923 amino acids and neurodegenerative disorders such as Parkinson’s disease and defects in its size is about 103 KDa. The different fragments of the gene were embryonic stem cell differentiation. This project aims at identifying cloned and expressed in BL21 (DE3) bacterial system. Four different inhibitors specific to BRD2 bromodomains by rational drug discovery gene fragments of DBC1 were cloned to pET28a vector and protein approach. induction was done using IPTG at 37°C and 20°C (Fig. 1). To have pure protein for structural studies, purification process is in progress. The main approach involves crystallization of BRD2-BD2 bromodomain and soaking the crystals in solutions containing potential inhibitors. These potential inhibitor compounds have been identified by in-silico screening using NCI-Diversity Set III library. The investigators have also successfully expressed, purified and crystallized BRD2-BD2 protein. In the initial experiment, they have dissolved twenty potential inhibitor compounds in buffer containing 5% DMSO. The investigators soaked BRD2 crystals overnight in these buffers and cryo-freezed them for diffraction studies.
Fig. The SDS-PAGE showing expression of both USP22 and DBC1 in BL21 (DE3)
8. Understanding the role of USP22 (Ubiquitin Specific Protease 22) in activation of SIRT1 through structure- function analysis. Investigator: Dr. B Padmanabhan
Fig. The BRD2-BD2 crystals observed in sitting drop vapor diffusion method USP22, the mammalian homolog of yeast Ubp8 is cytoplasmic 7. Mechanism of interaction of DBC1 with SIRT1 as a negative protein which catalyzes the deubiquitination of both histones H2A regulator. Investigator: Dr. B Padmanabhan and H2B, thereby acting as a coactivator in SAGA (Spt-Ada-Gcn5- Acetyltransferase) complex. A high-confidence interaction map The sirtuins are conserved NAD-dependent class III HDACs identifies SIRT1 as a mediator of acetylation of USP22 and the family, and they form an integrative link between metabolic control SAGA coactivator complex. USP22 is a highly specific interacting and transcriptional regulation. Sirtuins support the longevity by partner of SIRT1, and USP22 acetylation on multiple lysine residues increasing lifespan of the organism. They act as the metabolic sensors; alters the USP22 function of ubiquitination. The N-terminal Zn hence, regulate the pathways involved in age-related NDs. Sirtuins finger domain of USP22 interacts with the SIRT1protein. However, are structurally different with respect to their N- and C-termini. The the exact binding mechanism is still unclear. Knowing the structure of abnormal expression of Sirtuins may lead to diseases such as cancer the SIRT1-USP22 complex will unambiguously reveal how USP22 and various NDs. regulates the SIRT1 activity and hence the USP22 can become a potential therapeutic target in case of neurodegenerative diseases. SIRT1 activity is regulated by NAD+/NADH/NAM, by its protein The N-terminal SIRT1 binding domain, C-terminal domain and levels, phosphorylation and by DBC1, AROS and many such the full length were cloned to pET28a vector. Protein expression was interacting proteins. DBC1 is a gene, homozygously deleted in breast standardized using IPTG at different incubation temperatures. The cancer and some other tumors. Upon processing by caspases, the large purification of the protein is under process.
128 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
9. Analysis of structure - function of TULP3 (Tub like protein has paved the way to discover and design compounds, specific to 3) as a SIRT1 interactor. Investigator: Dr. B Padmanabhan hSIRT1. To discover new inhibitor compounds, the investigators performed virtual screening for hSIRT1 against DrugBank library Tubby-like proteins (TULPs) are present in all multicellular containing 1,716 compounds, and subsequently performed binding- organisms. The genetic mutation of TULPs can result in one or more energy analysis for the selected compounds. Two chemical classes, of three disease phenotypes: obesity, retinal degeneration, and hearing namely dipheynyl and oxycoumarin derivatives, have emerged from loss. Least information is known about the functional importance this study, and the investigators propose that the discovered hits may SIRT1 and TULP3 interaction. Hence the co-expression studies will be potential molecules to develop new chemical libraries for inhibiting give more experimental evidence for the interaction. In this regard the the enzyme activity of hSIRT1. investigators have cloned both SIRT1 and TULP3 to pETDuet-1 vector. To study the structure of TULP3, gene cloning was done using 11. Drug discovery of novel inhibitors for human Superoxide pET vector and expression of protein was checked in BL21 strain. Dismutase I (hSOD1). Investigators: Dr. B Padmanabhan, Recombinant protein was purified using Ni-NTA affinity purification. Dr. Richard Strange, Liverpool University, UK The final recombinant protein with His-tag was obtained from the ion-exchange chromatography. Human superoxide dismutase (hSOD1) is an enzyme involved in detoxification, such as removal of charged oxygen molecules called superoxide radicals. The mutation in the gene causes amyotrophic lateral sclerosis (ALS). The hSOD1 toxic gain-of-function is mainly due to the mutation in SOD1 gene, because of which protein gets aggregated and blocks the proteasomes which leads to motor neuron death in the early stages of the diseases. Since both aggregation propensity and protein stability strongly influences patient survival time after onset of symptoms, working on protein stability could be an important step to improve patient survival rate. Hence, identifying Fig. Pure protein of TULP3 after ion-exchange chromatography and developing potential library compounds to stabilize the functional hSOD1 dimerization are in need for the treatment of ALS. 10. Structure-function analysis of HDAC domain of human SIRT1 inhibitors by rational drug design approach. The hSOD1 cDNA was cloned into pET vector and protein with Investigator: Dr. B Padmanabhan (Funding by DST) His-tag was expressed in bacterial system and purified protein was obtained in soluble form. Multiple purification steps were performed SIRT1, a class III HDAC (Histone deacetylase) family protein, to get final pure protein. This protein was concentrated to 10mg/ml associate with cancer, diabetes and many other age-related disorders. concentration and used for crystallization screening. The hSOD1 In recent years, human SIRT1 has been drawing great attention protein was checked for its intact mass analysis and its purity by Mass in pharmaceutical industries as a therapeutic target to regulate its spectrometry analysis and found that its intact mass was 16.06KDa. function either by activators or inhibitors. The overexpression of The purity check of the protein was done by LC MS-MS analysis hSIRT1 leads to cancer; hence, inhibiting its HDAC function may be after in-gel trypsin digestion of the protein and found that protein is a better strategy for the treatment of cancer. The recently determined 98.90% pure. crystal structure of the HDAC domain of hSIRT1 (PDB Id: 4KXQ)
Fig. Binding of compounds #1–1 with hSIRT1. The close-view of the protein- ligand interactions for the compounds #1–2 are shown in (a) and (b), respectively. The respective ligands and the interacting residues are shown in sticks. The dotted lines denote hydrogen bonds between hSIRT1 and ligands. Fig. hSOD1intact mass showed on spectra and SDS PAGE of pure SOD1 before The oxygen and nitrogen atoms are colored in red and blue, respectively. MS-MS analysis
National Institute of Mental Health and Neuro Sciences 129| Annual Report 2014-15
Parkinson’s disease is characterized by selective loss of dopaminergic (DA) neurons in the substantia-nigra and not in the ventral- tegmental area and other catecholaminergic cell-group areas. Post-mortem analysis suggests that the main difference between these two regions of the brain having DA neurons is the density of astrocytes. The significance of region specificity and density of astrocytes in constituting the microenvironment of DA neurons is Fig. SOD1 Crystals in different precipitant conditions yet not elucidated. Present therapies targeted at the restoration of dopamine fail to slow progression of the disease and increasingly 12. Crystal structure of the MazG-related nucleoside triphosphate stem cell (SCs)-based therapies are getting considered as viable pyrophospho-hydrolase from Thermotogamaritima MSB8. alternatives. Hence in the present study, we aim to understand the Investigators: Dr. B Padmanabhan, Dr. Yoshitako Bessho, role of astrocytes in the survival of DA neurons using an in vitro RIKEN, Japan. primary midbrain DA neuron culture model and further elucidate the role of undifferentiated and differentiated MSCs in mimicking the The MazG family proteins, which are highly conserved in bacteria, supportive action of astrocytes on the survival of DA neurons. The are nucleoside triphosphate pyrophosphohydrolases that hydrolyze investigators have isolated, purified and differentiated astrocytes from all canonical nucleoside triphosphates, and are also involved in three different regions of neonatal brain and characterized for glial removing noncanonical nucleotide triphosphates to prevent their markers through flow cytometry. With purification and maturation incorporation into DNA or RNA. The primary structure of TM0360 of astrocytes the cultures showed a downregulation of microglial and from Thermotogamaritima MSB8 suggested that TM0360 is a oligodendrocyte markers. Gene expression studies showed differential MazG-related nucleoside triphosphate pyrophosphohydrolase. The expression of neurotrophic factors in naïve and matured astrocytes crystal structure of the TM0360 protein was determined by the from different regions of the brain and this will be assessed at protein MAD techniqueat 2.0 Å resolution. The asymmetric unit contains level too. At present, work is focused on standardization of yield and an intact dimer molecule. The overall structure of TM0360 is characterization of dopaminergic neurons from midbrain region. similar to the known structures of the dimeric MazG protein and dUTPases. The putative NTP binding pocket in TM0360, identified by considering the probable NTP-interacting residues and structural features, suggested that TM0360 resembles the C-terminal domain of Escherichia coli MazG, although TM0360 may be a truncated paralog of the N-terminal domain of Thermotogamaritima MazG (TM0913), according to its primary structure. The putative function of TM0360 is discussed, based on structural homology.
Fig. Representative immunofluorescence images of purified astrocytes from neonatal rat midbrain for GFAP, co-stained with β actin and DAPI (Magnification 40X10).
14. Establishing link between 6-hydroxydopamine, α-synuclein and vesicular dopamine release in an in vitro Parkinson’s disease model to evaluate the protective effect of human dental pulp stem cells. Investigator: Dr. Indrani Datta Fig. The structure of TM0360.(a) Ribbon diagram of the tertiary structure of (Funding by ICMR) TM0360 in the dimeric form. The two chains are colored yellow (chain A) and pink (chain B). The Mg2+ ions are shown as grey spheres. (b) A close-up view The relevance of the endogenous neurotoxin 6-hydroxydopamine (6- of the Mg2+ coordination geometry. OHDA) in the pathogenesis of Parkinson’s disease (PD) is established 13. Development of an in vitro model to assess the role through post-mortem analysis of PD patient’s brain-tissue and urine of endogenous astrocytes and adult stem cell-derived sample of Parkinsonian patients under levodopa medication. Till date, supportive cells on the survival of midbrain dopaminergic findings on the effect of 6-OHDA has been confined to the reports neurons. Investigator: Dr. Indrani Datta (Funding by DBT) of increase in ROS and mitochondrial damage leading to apoptosis. (Innovative Young Biotechnologist Award) But its effect on the key clinical features like α-synuclein aggregation,
130 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 resting vesicular pool and vesicular dopamine release is still not progenitors (NPs) derived from human embryonic stem cells (hESCs) reported. These parameters are required for well-definedin vitro to generate an in vitro model for HIE. hESCs are unique since in model system to evaluate neuroprotectants. Hence in the present study, being essentially derived from the inner cell mass of preimplantation the investigators employed an old in vitro model of PD to establish embryos, are thus capable of self-renewal and differentiation to all a link between 6-OHDA, α-synuclein phosphorylation, vesicular three derm layer lineages. Consequently, hESCs are considered a monoamine transporter-2 (VMAT2) expression and vesicular good reserve model for developmental events and the generation dopamine release along with measuring the changes in oxidant- of terminally differentiated cells in therapeutic strategies. The antioxidant system, mitochondrial membrane potential and apoptosis. investigators established simple and reproducible protocol to routinely The neuro-regulatory role of dental pulp stem cells (DPSCs) in the produce highly homogeneous cultures of neural progenitors, which cellular pathogenesis of this disease will be investigated. This in turn organize into neural tube-like rosettes when they are plated on would provide fundamental cues for translational medicine. The data appropriate ECM for terminal differentiation. Since HIE usually suggests that 6-OHDA induces phosphorylation and aggregation occurs during or near to birth therefore as per embryonic development of α-synuclein, decreases the resting pool of synaptic vesicles and in it overlaps with the gliogenic clock. These NPs derived from hESCs turn vesicular dopamine release; and these events precede apoptosis. would provide an opportunity to assess the effect of HI on its Experiments related to evaluate the neuroprotection through DPSCs differentiation towards oligodendroglial lineage, of human origin. are in progress.
Representative immunofluorescence images of neural stem cell markers like nestin and Pax6 in neural progenitors of RelicellhES2 (Magnification 20X10).
16. Preclinical studies on brain tumours: combination of adjuvants with different mechanisms of radiosensitization. Investigators: Dr. Vijay Kumar Kalia, Dr. Vani Santosh (Funding by DBT)
Studies on the effects of combining clinically relevant, low concentrations of TMZ (1 - 10 µM) with either 2-DG (0.5 – Representative immunofluorescence imagesof control and 6-OHDA treated 1 mM), or ATRA (2-5 µM) (4 hrs. treatment) on malignant SH-SY5Y cells expressing phospho serine-129 a-synuclein. DAPI was used to glioma cells were continued. Micronuclei, nuclear fragmentation, counterstain the cell nuclei (Magnification 40X10). chromatin condensation, cytoplasmic degeneration and membrane 15. Development and assessment of human embryonic stem blebbing, etc. induced by drug treatments drug(s) were increased cell derived neural progenitors as a model for hypoxic- by radiation(U87MG and U251as well as early passage primary ischemic like injury – Implications for Hypoxic Ischemic malignant glioma cell lines coverslip cultures- Acridine Orange Encephalopathy. Investigator: Dr. Indrani Datta (Funding Staining).U87MG and U251MG cells also showed apoptosis by CSIR) (Annexin V Assay, FCM), 3 hours after drug ± radiation treatments.
Hypoxic-ischemic encephalopathy (HIE) is a condition where severe TMZ is a front line drug, used in combination with conventional brain injury occurs in neonates due to birth asphyxia (American radiotherapy, and 2-DG has also been used in clinical trials on Academy of Pediatrics). This condition can arise due to variety of malignant glioma patients. The study shows that combination of these perinatal causes that interrupts uterine and fetal blood flow and/ adjuvants (2-DG or ATRA) could decrease the TMZ doses required or hypoxia. There are practically no therapies other than supportive for TMZ- Radiotherapy of malignant gliomas, thereby reducing its measures for perinatal HIE. The investigators propose to use neural toxic side effects.
National Institute of Mental Health and Neuro Sciences 131| Annual Report 2014-15
17. Neuron astrocyte interaction in relation to excitotoxicity in (DST-WoS Fellow), Guide: Dr. B Padmanabhan (Funding spinal cord. Ms. Shiksha Sharan. Guides: Dr. Preeti G Joshi, by DST and DBT) Dr. Nalini A The BRD2 protein, which belongs to the BET Family, is a potential Excitotoxicity has been implicated in several neurodegenerative therapeutic target for neurological disorders. The aim of the study is disorders including Amyotrophic Lateral Sclerosis (ALS). Several to obtain small molecule inhibitors for BD1 and BD2 bromodomains studies have indicated the role of glial cells in ALS pathogenesis. of BRD2 by rational drug discovery approach. The investigators have Astrocytes actively participate in neuronal excitability and obtained initial hits from the NCI Diversity III library. The selected neurotransmission by special transporters and receptors present on compounds were validated by molecular dynamics (MD) simulation their membrane. This study aims to determine the morphological and studies. functional differences in neuron-astrocyte network in anterior horn and posterior horn of spinal cord. The glutamate handling properties 20. Effects of temozolomide and its combination with 2-DG/ of astrocytes in anterior horn and posterior horn of spinal cord is ATRA on proliferation, cytotoxicity, ultra-structure and being investigated. radiation response of malignant human glioma cells. Ms. Kalyani Kumari. Guides: Dr. Vijay K Kalia, Dr. BK 18. Structural and functional analysis of therapeutic proteins, Chandershekar Sagar, Dr. KL Narasingarao (Funding by sirtuins and sod1 associated with neurodegenerative diseases. DBT) Ms. Manjula Ramu (CSIR SRF Fellow). Guides: Dr. B Padmanabhan, Dr. Srinivas Bharath (Funding by DST) Combination of Temozolomide with 2-Deoxy-D-Glucose (2- DG) or All Trans Retinoic Acid ATRA) at clinically relevant, low Neurodegeneration is the progressive loss of structure and function of concentrations significantly increased radiation induced cellular neurons, leading to the death of neurons. Neurodegeneration results damage in early passage primary cultures—derived from different in the development of Parkinson’s, Alzheimer’s, and Huntington’s malignant gliomas (Grade III/ IV). Proliferation response (cell counts diseases. Different neurodegenerative disorders (ND) include atypical and MTT assay) was also significantly reduced by these treatments. protein assemblies and oxidative stress which lead to cell death. Since Cell death (Sub G1 peak in Flowcytometry assay, Macrocolony formation) the proteins such as Sirtuins and Superoxide dismutase 1 (SOD1) are was also increased in U251MG cells. ATRA also induced differentiation directly or indirectly involved in the abovementioned disorders they in primary glioma cultures. These data suggest that combination of have grabbed the global attention in drug targeting. either 2-DG or ATRA could increase the response of malignant gliomas to TMZ-Radiation therapy. The increased expression of SIRT1 in ND helps in treating the symptoms. The regulation of SIRT1 activity can be achieved by its interacting proteins such as DBC1, USP22, AROS and etc. the Biostatistics understanding of interaction mechanism would help us to have a better strategy to treat ND. In this regard interactors of SIRT1 are 1. COE Project: Genetic and protein biomarkers for cloned and expressed in a bacterial system to get pure protein for epileptogenesis and pharmacoresistance in mesial temporal structure-function analysis. Various clones of SIRT1 and SIRT2 sclerosis and focal cortical dysplasia. Co-investigator: Dr. K proteins were expressed in E-coli and purified protein was used Thennarasu (Funding by DBT, New Delhi) for crystal screening. In-silico analysis was performed and virtually screened few drug molecules that can inhibit the SIRT1 activity. The 2. Migration, poverty and access to health care: A study on validation of these small molecules for its inhibition will be done by people’s access to health systems’ response. Investigator: Dr. deacetylation assay. P Marimuthu, Dr. DK Subbkrishna, Dr. K Sekar, Dr. Manoj Kumar Sharma, Dr. RT Venkatesh, Deputy Director (State In addition, SOD1 was also produced in large scale for the structural Surveillance Unit), Office of the Director General of Health analysis. Since the dimerization stabilization plays a major role in ALS, Services, Government of Karnataka, Bangalore (Funding by some of the small molecules will be checked for SOD1 stabilization. ICMR) SOD1 apo crystals that were obtained from pure protein were used for X-ray diffraction and structural analysis. Sixty six percent of the surveyed sample constituted people who knew about the health camp activities and attended the health camp. 19. Structure based approach to discover and develop potential About 95 percent of the surveyed sample knew about the health camp inhibitors for the BRD2 bromodomains and delineate their activities and accepted that the service in the health camp was useful. effects in neurodegenerative models. Ms. Shruti Mathur It is observed that the utilisation of government health facility service
132 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 has increased by 20 percent in the intervention area. Although medical recruited for the study in the pro-band group. Of which, the whole set care from a private doctor was the regular source for more than 50 of assessments has been completed for 19 families (i.e.36 first degree percent of the respondents of both the groups at the assessment levels, relatives of children with ASD) there is a change in their medical care seeking behaviour with regard to government health facilities. In the control group, 11 individuals have been recruited for the study and all the assessments are completed. The process of report writing Number of pregnant women not seeking care has come down is in progress. comparatively for both the groups at post-assessment. End line survey data demonstrated that more than 95 percent of the study participants 4. Community needs and resource mapping in community child of both the groups at post assessment were found to have been and adolescent mental health. Investigator: Dr. Shekhar provided with iron and folic acid tablets (IFC) by the government Seshadri (Funding by RN Murthy Foundation) health facility personnel during their last pregnancy. Comparison between the groups showed that vaccines such as Hepatitis B-0, This project sought to conduct an in-depth assessment of community BCG (0-1 month), DPT-1, Hepatitis B-1 and OPV-1 were reported child and adolescent mental health needs and resources, with the by more number of participants at post assessment than at pre- following objectives: (i) to map the types of child and adolescent assessment, whereas the percentage for other vaccines was equal or mental health resources and services that communities can access lower at post assessment. The similar findings were observed even in (ii) to identify the various types and cadres of service providers and the non-intervention group. The overall findings of both the groups at assess their knowledge, skills and capacities with regard to provision both levels of assessment reveals that majority of the respondents got of services to children and adolescents (iii) to identify vulnerable their children vaccines appropriate to the age of the child. populations and understand community and caregiver priorities and concerns about child and adolescent mental health (iv) to develop a 3. Structural equations modeling approach to study comprehensive database of service providers and services and list gaps latent relations among clinical, immunological and therein in order to enable the establishment of the comprehensive Neuroimaging parameters in Schizophrenia. Investigators: community-based service model. Dr. DK Subbakrishna, Dr. Mariamma Philip, Dr. G Venkatasubramanian (Funding by DBT) Over the project period, needs assessments and preliminary orientation and sensitization programs were conducted for stakeholders in three key sectors that work with children, namely health, education Child and Adolescent Psychiatry and welfare. Interviews, focus group discussions and workshops were conducted to understand the types of mental health problems 1. Autism and epilepsy – an exploration of a relationship. common in urban slum communities, the mental health services Investigators: Dr. Shoba Srinath, Dr. Satish Girimaji, Dr. available to children and adolescents, as well as the knowledge and Shekhar Seshadri, Dr. John Vijay Sagar, Dr. P Satishchandra, skill needs and gaps of the service providers. The needs assessment Dr. Sanjib Sinha, Dr. Shivshankar, Dr. Yamini, Dr. DK was located in Bangalore South Zone targeting 13 primary healthcare Subbukrishna (Funding by ICMR) centres serving vulnerable urban populations (slum communities), and 46 anganwadis, 21 government schools and RBSK functionaries 2. Imaging and biochemical correlates in children with Autism, located within/ serving these communities. Additionally, 32 child care with and without Epilepsy. Investigators: Dr. K John Vijay institutions (CCIs), governmental and non-governmental, working Sagar, Dr. Satish Girimaji, Dr. Shekhar Seshadri, Dr. Shoba with children in difficult circumstances i.e. with street and working Srinath, Dr. John P John, Dr. Chandrajit Prasad, Dr. DK children, orphan and abandoned children, HIV infected/ affected Subbukrishna (Funding by ICMR) children, children with disability and children affected by gender and sexuality vulnerabilities, participated in the needs assessment 3. A study of brain imaging, neuropsychological profile, workshops. genetic markers and eye movements in first degree relatives of children with Autism spectrum disorders (ASD). 5. Community child and adolescent mental health service Investigators: Dr. Srinath S, Dr. Girimaji SC, Dr. Seshadri projects. Investigator: Dr. Shekhar Seshadri (Funding by SP, Dr. Vijay Sagar KJ, Dr. Ravindranath V, Dr. Kumar K, Dr. Department of Women and Child Development, Govt. of Murthy A, Dr. Prasad C (Funding by DST) Karnataka)
From the onset of the project, 28 children diagnosed with Autism This project is a community-based child and adolescent mental health Spectrum Disorder with their 48 first degree relatives have been intervention in accordance with the tenets of primary healthcare and
National Institute of Mental Health and Neuro Sciences 133| Annual Report 2014-15 inter-sectoral development. A pilot proposal—since none of its kind group improved significantly on all measures including severity of exists in India—it aims to develop a model for community-based anxiety, level of functioning and quality of life. child and adolescent mental health that will be replicable in other (urban and rural) areas of the country. It seeks to address the gap in 8. Factors affecting outcome in oppositional defiant disorders: child and adolescent mental health services in the Indian context, a three-month prospective study. Dr. Raghunandan Mani. wherein screening and early intervention and/or psychosocial care Guides: Dr. Vijay Sagar KJ, Dr. Srinath S, Dr. Girimaji SC, provision by non-specialists, exists to an extremely limited extent; Dr. Seshadri SP and where provision of mental health services are largely restricted to curative services in tertiary care facilities, thereby limiting access to A total of 78 children were screened, out of which 50 children were most children in need. included in the study at baseline and were diagnosed to have ODD as per DSM-IV-TR diagnostic criteria. The follow-up rates were This project therefore seeks to implement a community-based child 92% (N=46) for 06th week assessment and 90% (N=45) for 12th week and adolescent mental health intervention in the Indian context, assessment. Of the sample, 87% of children continued to have ODD so that the experience and lessons learnt will be used to develop a at 12 weeks and 13 per cent remitted. Treatment as usual in clinical comprehensive model for community-based child and adolescent setting showed significant improvement in children and adolescents mental health care that could be replicated elsewhere in the country. with ODD over 12 weeks. The project objectives are: (i) Establishment of community-based child and adolescent services; (ii) Training and capacity building 9. A clinical study and short term outcome of children and of childcare workers and staff from various governmental and adolescents with history of child sexual abuse. Dr. Sowmya non-governmental agencies, including schools; (iii) Draw from Bhaskaran TS. Guides: Dr. Shekhar P Seshadri, Dr. Shoba implementation experiences to develop a comprehensive community Srinath, Dr. Satish C Girimaji, Dr. John Vijay Sagar child and adolescent mental health service model that may be replicated elsewhere in the country. The aim was to study the clinical characteristics and course, outcome of children with history of CSA over 12 weeks. A total of 29 children With a view to addressing the service needs and gaps, the project with history of CSA were compared to 29 controls without history of seeks to extend child and adolescent mental health service coverage, CSA. The commonest diagnosis in children with history of CSA was particularly to cover those who are most vulnerable. The project depressive disorder followed by Post-Traumatic Stress Disorder. Older comprises a comprehensive plan to provide community-based Child age, male gender, longer duration of abuse, abuse by multiple persons, and Adolescent mental health promotive, preventive, and curative care threats during abuse was associated with higher baseline severity. The in urban and later in rural sites through direct service delivery and course and outcome has been favourable and the children with history training and capacity building of child care workers from community- of CSA improved significantly in all measures. based governmental and non-governmental agencies/institutions and professionals, including schools, NGOs, anganwadis and health 10. Study of suicidality in children and adolescent in an inpatient workers. This project entails a strong inter-sectoral collaboration with setting. Dr Arun Vangili. Guides: Dr. Shoba Srinath, Dr. the health, education and social justice and empowerment sectors, Satish Girimaji, Dr. Shekhar Seshadri, Dr. John V Sagar) including the Dept. of Women and Child. Aim of the study is to study the prevalence and clinical characteristics 6. Neuro-anatomical and cognitive correlates of short-term of suicidality in children admitted to an in-patient facility. All the course and outcome of childhood and adolescent psychoses children without developmental disorders were screened for suicidality and bipolar disorder. Investigator: Dr. ShobaSrinath, Dr. and children with affective disorders were assessed for severity of Mariamma Philip (Funding by CEIB) suicidal ideation using appropriate instruments. A total of 90 children hospitalized over a period of 105 consecutive days were screened for 7. Short term outcome of anxiety disorders in children and suicidality. About half the number of children, who were included, had adolescents. Dr. Preeti Kandasamy. Guides: Dr. Girimaji SC, at least one dimension of suicidality. Experience of bullying, experience Dr. Srinath S, Dr. Seshadri SP, Dr. Vijay Sagar KJ of school difficulties, school refusal, difficult temperament, psychiatric diagnosis of depressive disorders, adjustment disorder, conduct and A total of 98 children were screened using Screen for Child Anxiety oppositional defiant disorders were statistically significant differences Related Disorders (SCARED) and 60 meeting inclusion and between the two groups. exclusion criteria were included after obtaining consent and assent. Assessments were done at baseline, 12 weeks and 24 weeks. The 11. Brief intervention study for families of children with autism course and outcome has been favourable overall, and children as a spectrum disorder: NIMHANS Model. Dr. Pooja Panchal.
134 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Guides: Dr. Shoba Srinath, Dr. Satish C Girimaji, Dr. Shoba Srinath, Dr. Shekhar Seshadri, Dr. K John Vijayasagar Shekhar P Seshadri, Dr. John Vijay Sagar (Funding by NRHM, Govt. of India)
Prevalence of ASD is increasing worldwide. NIMHANS, Bangalore The aim of the project was to train psychologists employed in District being a tertiary care centre also receives families of children with Early Interventions Centers in different states of India. The objectives ASD, either for diagnostic purpose or higher inputs for management. were to facilitate acquisition of knowledge and skills required for The objectives of the study are to (a) consolidate and formalize screening, diagnosis and intervention for children in the age group interventions already practised in NIMHANS, Bangalore into a 0-5years with or at risk for developmental delays, intellectual disability, manual (b) examine the effectiveness of manual by implementing it on developmental disorders and behavioral disorders. 20 families with children with ASD. Twenty families of children with ASD will receive two weeks of inpatient intensive intervention. Pre The training programme was conducted in the month of September and post-assessment of child’s functioning, parental stress and coping (1-30 September 2014).There were fourteen psychologists from the will also be done. states of Jammu and Kashmir, West Bengal, Tamil Nadu, Sikkim, Manipur, Kerala and Madhya Pradesh. The training programme 12. A study of eye movements in juvenile-onset obsessive consisted of imparting knowledge on the topics related to evaluation compulsive disorder. Dr. Anirban Ray. Guides: Dr. John Vijay of children with Autistic spectrum disorders, intellectual disability, Sagar, Prof. S Girimaji, Prof. S Srinath, Prof. SP Seshadri, testing of intellectual functions, developmental assessment, screening Dr. G Venkatasubramanian checklists, intervention for developmental disorders and parental counseling. The methodology of the training programme consisted of Ventral prefrontal cortex and striatal circuitry are especially implicated observation of case discussions in the IP and OP services of the Dept. in neuro-biological causation of OCD. Eye tracking studies especially of Child and Adolescent Psychiatry, NIMHANS, didactic lectures, anti-saccade tasks have already proven value in adults with OCD. For demonstrations of testing, scoring and writing of reports, small group children, studies are less in number. Study will involve assessment of discussions, debriefing sessions, home-work assignments, role-plays, anti-saccade tasks in children with OCD between 6-18 years of age, in and topics for self-assignments. Trainees visited the Departments comparison with normal controls. Thirty children in each group will of Speech Pathology& Audiology and DPNR. Faculty members, be included for the study. Children with OCD will be included from doctoral students from the Department of Child and Adolescent the OPD & IPD of Psychiatry and Child and Adolescent Psychiatry Psychiatry were the resource persons. Departments, after proper informed consent from at least one parent and child. Error rate and accuracy will be compared between normal 2. Development, implementation and evaluation of a training children and those with OCD. program in mental health care for central reserve police force (CRPF) personnel. Investigators: Dr. LN Suman, Dr. Seema 13. Follow-up study of children and adolescents diagnosed with Mehrotra, Dr. M Manjula, Dr. Sailaxmi Gandhi, Dr. K Arun attention deficit hyperactivity disorder. Dr. Rani Jancy AR. (Funding by ICMR/DHR) Guides: Dr. Shobha Srinath, Dr. Satish C. Girimaji, Dr. Shekhar P Seshadri, Dr. John Vijaya Sagar The aim of the project is to develop, implement and evaluate a training programme in mental health care for commandants, doctors Follow-up studies in India are very few in the area of ADHD. This and nurses serving in the CRPF. A multi-phase methodology will be study attempts to find the clinical status and functionality of children employed to develop the wellness programme material, intervention and adolescents diagnosed with ADHD 18–36 months back. This modules and evaluate the effectiveness of the programs. Training of is a catchup follow-up study of ‘A Prospective study of the short Trainers from different centres across the country is also envisaged. term course and outcome of children and adolescents with Attention Deficit Hyperactivity Disorder in a tertiary care centre’ conducted in 3. Aggressive driving and anger on roads among two wheeler NIMHANS by Dr. Preeti Jacob. riding college youth. Investigators: Dr. Seema Mehrotra, Dr. Paulomi Sudhir, Dr. Manoj Sharma, Dr. Neelima Chakrabarthy (Funding by CRRI, New Delhi) Clinical Psychology This project aimed at examining the prevalence of aggressive driving 1. Training psychologists at DEICs under Rashtreeya Bala amongst two-wheeler riding college youth, the correlates of the same Swasthya Karyakrama (RBSK) - An initiative under the rural as well as documenting the experience of negative emotions, especially health mission, Government of India. Investigators: Dr. anger on the roads. An intervention program for promoting safe and Uma H, Dr. Satishchandra Girimaji, Dr. BN Roopesh, Dr. respectful riding behaviors in youth (SMART RIDERS) has been
National Institute of Mental Health and Neuro Sciences 135| Annual Report 2014-15 developed. It has been field tested with respect to gains in knowledge, pre, post neurofeedback training (NFT) in patients with TBI. Sixty changes in riding attitudes and efficacy about emotional regulation on patients diagnosed with TBI according to ICD-10 (WHO, 1992) will the roads. A manual for training for trainer is being developed. be recruited to one of the two groups within a month of injury into intervention group (neurofeedback training) and treatment as usual. 4. Youth engagement program: Development and examination The serum levels of the above will be compared before and after NFT of psychosocial outcomes. Investigators: Dr. Seema in both groups to elucidate the biochemical mechanisms which may a Mehrotra, Dr. Srikala Bharath, Dr. Ravikesh Tripathi possible role in the recovery. The study will be helpful in administering (Funding by ICSSR) the NFT in the early stages of TBI, indicating that along with neural plasticity NFT augments improvement cognition and QOL. The project was aimed at developing brief program for youth engagement and field testing the same in order to examine its 7. Parenting styles, perfectionism and self-conscious emotions psychosocial impact. The pilot phase entailed examining the in young adults: A socio-cultural perspective. Investigators: psychometric properties of the relevant assessment measures/outcome Dr. Paulomi M Sudhir, Dr. Seema Mehrotra, Dr. DK Subba indicators. A brief youth engagement program (ENGAGE TO Krishna (Funding by ICSSR) CHANGE) has been developed which consists of an orientation workshop and an extended support phase for the participating youth The study is aimed at understanding parenting styles and perfectionism to implement their plans developed during the orientation workshop. as contributors to self-conscious emotions such as shame and guilt. The themes covered for youth engagement in this program include: The study will be carried out on young adults, aged between 18-30, mental health, disability, environment and road safety. The field using both paper pencil and interview methods (to be conducted on a testing of the program has indicated gains on a standardized measure sub-sample).The sample for the paper pencil assessment will include of self-esteem, sense of mastery as well as multiple qualitative indices. 300 young adults from various colleges and work place settings. The A manual for trainers has been developed. pilot phase of the study is in progress.
5. Strengthening the pyramid of mental health care in India: 8. Cognitive Behaviour Therapy (CBT) in partial responders Development and pilot testing of a self-care intervention for with OCD: A randomized controlled trial. Investigator: Dr. depression. Investigators: Dr. Seema Mehrotra, Dr. Paulomi Paulomi M Sudhir, Dr. YC Janardhan Reddy, Dr. Suresh Sudhir, Dr. Jagadish Thirthalli (Funding by ICMR). Bada Math, Dr. K. Thennarasu (Funding by ICMR)
This project aims to develop an internet-based product for individuals The study is aimed at examining the efficacy of CBT for partial in the community suffering from mild depression, to be used as a responders with OCD. A sample of 100 patients will be randomized self-care package to deal with depressive symptoms. This product to either CBT with pill placebo or Augmentation with Risperidon will be developed and field tested during the project. This is in line and stress management. Ratings at baseline, post and follow-up with the WHO recommendation for strengthening the pyramid of sessions will be carried out on symptom ratings, mood, and quality care by developing self-care programs that form the base of the of life. It is proposed that at least 2-25 sessions of intervention will pyramid (being required by /helpful for a large number of people be delivered. The study has just commenced with recruitment of in any community) in contrast to the specialist care at the top of the staff. pyramid. 9. Teasing experiences, interpersonal sensitivity and body 6. A study of cognitive functions and biochemical correlates in image in patients with emotional disorders. Investigators: traumatic brain injury. Investigators: Dr. Jamuna Rajeswaran, Dr. Paulomi M Sudhir, Dr. Manjula M, Dr. MP Sharma, Dr. Dr. Rita Christopher (Funding by DBT) Mariamma P
Traumatic brain injury (TBI) is a complex injury with a broad The study is aimed at understanding the impact of teasing and spectrum of symptoms and disabilities. The impact on a person and interpersonal sensitivity on the development of body schema—such his or her family can be devastating. Cognitive difficulties are very as avoidance, dysfunctional attitudes and psychological symptoms of common in people with TBI. Studies have shown neuropsychological anxiety, stress and depression. rehabilitation to be useful in improving the cognitive functions and day to day functioning. Neurofeedback training is an operant The study will be carried out on 70 adult patients seeking treatment at conditioning procedure whereby an individual modifies the amplitude, the Behavioural Medicine Unit with emotional disorders. Assessments frequency or coherence of the electrical activity of his/her own brain. will be carried out using both paper and pencil measures. The pilot The aim of the present study is to examine the biochemical correlates phase of the study is in progress and tools are being finalized.
136 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
10. Computer assisted retraining programme to improve 12. ICMR National task force on migrant health. Investigators: cognitive functions for elderly. Investigators: Dr. Keshav Dr. Marimuthu P, Dr. Manoj K, Dr. Sharma, et al. (Funding Kumar (Funding by DST) by ICMR)
Normal aging is associated with cognitive decline in the domains of 13. Social media addiction and sexting behavior among youth memory, speed of processing and executive function. Mild Cognitive in India and Australia. Investigators: Dr. Manoj Kumar Impairments (MCI) is known to be a transition stage between Sharma, Dr. David Mellor, Dr. Binaca (School of Psychology, normal aging and dementia. Specifically designed cognitive training Deakin University, Victoria, Australia and Dept. of Clinical programmes are known to reduce the risk of rapid cognitive decline Psychology, NIMHANS, Bangalore, Karnataka) in healthy normal elderly, individuals with MCI and dementia. Improvement in cognitive function improves the quality of life; There is a dearth of work in the Indian context pertaining to possibly delay dementia and decreases dependence. This study aims investigating the degree to which sexually-explicit content is accessed to develop theoretically driven, neural circuitry based, culturally or sent by electronic means. Taking into account the recent increase appropriate, computerized cognitive training programme to improve and publicity related to sex related crimes in India, as a part of the cognitive function in normal elderly, MCI and dementia. Both the collaboration between NIMHANS, Bangalore and Deakin University, healthy normal controls (N=10) and clinical group (n=10) received 30 Australia, the present work assessed social media addiction and the sessions of cognitive retraining on a daily basis. Post assessment the “sexting” behavior in the age group of 18-25years (male/female) and healthy normal elderly group improved on tests of attention in terms its association with mental health. Sexting questionnaire/screening of decrease in omissions and commissions, working memory, verbal question to assess social media addiction; Rosenberg self-esteem memory on both immediate and delayed recall on tests of logical questionnaire; McMaster family functioning scale, DASS 21 and memory as well as word list learning, visual learning and memory DSI14 and Facebook intensity questionnaire were used. Preliminary delayed recall and speed of processing. The clinical group improved findings revealed the association of sexting with low self-esteem, on attention and speed of processing and verbal and visual Memory. family functioning and psychiatric distress.
11. Exploration of need and efficacy of internet based program 14. Psychometric properties of difficulties in emotion regulation for management of psychological problems. Investigators: scale in Indian population. Investigators: Dr. M Manjula, Dr. Manoj Kumar Sharma, Dr. Paulomi Sudhir, Dr. Dr. K Thennarasu Prabha Chandra and Dr. SK Chaturvedi (Funding by Dr. Ramachandra N Moorthy Foundation for mental health and The study is carried out owing to the lack of scales to assess emotion Neurological Sciences) regulation for the Indian population. DERS being the most frequently used tool for assessing emotional regulation, the study attempts to The internet based program evolved to provide the authentic educative validate DERS in Indian culture. information about psychological problems as well as online guidance to manage their day-to-day stressors. It also facilitated the initiation The main aim of the study is to establish the psychometric properties of treatment for these psychological problems. The sample consisted of Difficulties in Emotion Regulation Scale (DERS) in Indian of 500 subjects (both male and female) in the age range of 20-50 years. sample. The objectives of the proposed study are to examine the They were recruited from the general community for the assessment of factor structure, to establish the reliability, validity, and to examine the felt needs for the program and screening of psychological problems and emotion regulation difficulties in community sample. Sample consists 50 subjects amongst them (with presence of psychological problems- of 350 subjects from the community population selected using snow anxiety, depression, somatic complaints and stress, familiarity with ball technique, aged between 18 and 50 years. The participants will be the internet usage) were recruited for the internet based educational assessed using Socio-demographic data sheet, Difficulties in emotion program. The education program(www.saumanasa.org) consisted of regulation scale, Depression, anxiety and stress scale and Negative affect assessment (in question-answer format) of problems, educating them scale of PANAS. The study is currently in the data collection phase. about the psychological problems, identifying unhelpful, irrational thoughts/coping behaviors and strategies required to handle them. 15. Stress management in youth: A preventive intervention. Sessions were conducted weekly and participants given homework/ Investigators: Dr. M Manjula, Dr. Roopesh, BN, Dr. worksheet assignment to facilitate practice between the sessions. Mariamma Philip (Funding by Indian Council for Social Online follow-up assessment using e-mail reminder facility/SMS’s Science Research) (integrated in the program) was carried out at one-month interval. Participants appreciated its utility in getting information as well as in The aim of the study was to assess the prevalence of depression and following the steps for various coping behaviors. suicidal risk and to examine the efficacy of a stress management
National Institute of Mental Health and Neuro Sciences 137| Annual Report 2014-15 prevention programme for Youth. The specific objectives were to 19. Professional development of clinical psychology trainee develop a prevention programme and examine its efficacy in reducing therapists. Investigators: Dr. Poornima Bhola, Dr. Ahalya depression and suicidal behaviours and coping. Raguram (Funding NIMHANS Intramural Research Grant) The sample comprised school and college students belonging to private and government schools and colleges. The sample was selected This study aims to assess therapist characteristics, positive and using stratified random sampling. The sample included for the negative aspects of work experience and professional development exploratory study was 1428. The sample was taken from six schools among Clinical Psychology trainee therapists in India. This and six colleges. The inclusion criteria for the study were individuals included theoretical orientation, sources of learning, therapeutic in the age range of 13-19 years and who can read and write either skill, perceived progress, therapeutic difficulties ad coping strategies, English or the local language Kannada. The sample for intervention cultural aspects of psychotherapeutic practice, interpersonal manner, group was taken from three schools and three colleges (n=379). personal functioning and satisfaction with supervision and the Suicidal behaviours scale was validated on 200 samples. training setting.
The study was carried out in different stages: i) Validation of the The data collection is nearing completion; data entry and qualitative suicidal behaviours scale ii) Preparing the prevention program and analysis are ongoing. A total of 86 trainee therapists from the conducting workshops iii) Preparing the module for suicide prevention Department of Clinical Psychology and select M.Phil. Clinical iv) Intervention and post assessment. All the phases of the study are Psychology training institutes across the country, completed the completed, analysis of the results is being carried out and preparation assessment at the end of their training. of the project report is in progress. A two-point assessment has been completed for a sub-sample of 37 16. Neural effects of cognitive remediation in schizophrenia: An trainee therapists; at mid-point and at the end of training to assess ERP and fMRI study. Investigators: Dr. Devvarta Kumar, changes in various domains of professional development. Nineteen Dr. BN Gangadhar, Dr. Ganeshan Venkat Subramanian, Dr. trainee therapists completed the assessment at the end of their first Shivaram Varambally, Dr. Rose D (Funding by DBT) year of training.
This study aims to see the neural effects of cognitive retraining 20. Ethical dilemmas experienced by clinical psychology trainee (specifically home-based training) in patients with schizophrenia. The therapists. Investigators: Dr. Poornima Bhola, Dr. Ahalya schizophrenia patients will be randomly divided into three groups – Raguram home-based remediation group, clinic-based remediation group and the wait-list control group. Pre- and post-neuropsychological and Ethical dilemmas are inevitable during psychotherapeutic interactions neurophysiological (fMRI and EEG based ERP) changes will be and these complexities and challenges may be magnified during the assessed to determine the effects of remediation. The pilot phase of training phase. The experience of ethical dilemmas in the therapy the project is over and the main phase has started. space and the methods of resolution were examined among 35 clinical psychologists in training, through an anonymous and confidential 17. Determining sensitivity and specificity of event related online survey. The responses to four open-ended questions about potentials for its use as cognitive function biomarker in any one ethical dilemma encountered during therapy were analysed Schizophrenia. Investigator: Dr. Devvarta Kumar, Dr. using thematic content analysis. The results highlighted salient Shivaram Varambally (Funding by DBT) ethical dilemmas centering on confidentiality and boundary issues. Trainees also raised ethical questions regarding therapist competence, This study is intended to see the sensitivity and specificity of various beneficence and non-maleficence of therapeutic actions and client EEG based event-related potentials in schizophrenia. The ERP autonomy. Adequate resolution was reported by 57 per cent of the paradigms have been developed and the process for recruitment of trainees, with prominent methods being supervision or consultation JRF has been started. and guidance from professional ethical guidelines. Trainees elaborated on the limitations of professional codes in effective resolution. 18. Rorschach comprehensive system: Preliminary norm for The findings have implications for the strengthening of training Indian adults. Investigators: Dr. Devvarta Kumar, Dr. Manoj and supervision methodologies and professional ethics codes for K Sharma psychotherapists and counsellors in India.
The study has been initiated. It is intended to develop preliminary 21. Explanatory models of mental illness among caregivers of norms for comprehensive system of Rorschach for Indian adults. mentally-ill referred to rehabilitation services. Investigators:
138 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Dr. Poornima Bhola, Dr. Hesi Herbert, Dr. Devvarta Kumar, of mental healthservices. School and college youth are a high-risk group Dr. Sailaxmi Gandhi, Dr. SK Chaturvedi and educational institutions are potential sites for early identification by teachers and school personnel. The study aimed to examine teachers’ This project aims to study the explanatory models of mental illness knowledge, attitudes and awareness of non-suicidal self-injurious among caregivers of individuals with psychiatric disorders seeking behaviours among students. The sample consisting of 152 teachers treatment at a tertiary care neuropsychiatric hospital. (high school teachers, pre-university and undergraduate college) from 21 private and government institutions, completed a questionnaire The objectives are to explore the explanatory models of care givers developed for the study. Cutting was identified among the most of mentally ill and to study the relationship with socio-demographic common forms of self-injury 47.4 per cent of teachers. There were variables and select clinical variables. The sample will consist of 60 varied responses about the rates of self-injury. The results indicated caregivers of inpatients or outpatients, with a psychiatric diagnosis divergent and mixed perceptions about the relationship between self- referred to Psychiatric Rehabilitation Services. The study is injurious behaviours and suicide. Teachers felt that students engaged in exploratory in nature with a single group and purposive sampling. The self-injurious acts primarily to draw the attention of others in the social tools used for assessment are a Socio Demographic Data Sheet and environment. There was inadequate recognition of the intrapersonal Barts Explanatory Model Inventory (Rudell, 2005). The pilot study and emotion-regulation functions of self-injury. The relationships has been completed and the main study has commenced. between teachers’ knowledge, confidence in dealing with student self- injury and difficult emotional responses are discussed. The findings 22. Use of, and attitudes towards, online mental health services: have implications for relevant resource material, information/training A cross-cultural comparison of Indian and Australian health formats and school and college policy inputs. service consumers. Investigators: Dr. David Austin, Deakin University, Australia, Dr. Poornima Bhola, Dr. Manoj 24. Early behavioural and developmental indicators of autism. Sharma, NIMHANS, Bangalore. Australia site: Ms. Jayda Investigators: Dr. M. Thomas Kishore (Funding by Reeta Akder, Ms. Chloe Tebble, Ms. Layla Abdallah (IRB approval Peshawaria Fellowship of the India Vision Foundation, New obtained) Delhi)
This cross-cultural study examined use of, and attitudes towards, online The study identified specific developmental and behavioural mental health services among Indian and Australian health service indicators in specific to autism. A scale has been developed based on consumers. The sample of 492 participants (297 from Australia and the indicators, which can identify children at-risk for autism from 195 from India, ranging in age from 18 years to 78 years) completed six months to four years of age. These findings in general will help either an online or paper and pencil survey. Sixteen per cent of the us identify autism early so that intervention could be started at the total sample preferred eMH, whilst 84 per cent participants preferred earliest. face-to-face mental health services. The results indicated a significant negative relationship between age and e-health literacy. There was 25. Electrophysiological and Neuropsychological correlates of significantly lower e-health literacy among the Indian participants. treatment outcome in ADHD children. Investigators: Dr. No statistically significant differences were found between Indians Roopesh BN, Dr. Shoba Srinath, Dr. Satish Girimaji, Dr. and Australians in relation to stigma towards mental illness, stoicism, Shekar Sheshadri, Dr. John Vijayasagar, Dr. Keshav Kumar internal and chance locus of control. Australian participants scored (Funding by DBT) higher on others locus of control. Multiple Regression analysis revealed that the combination of age, e-health literacy, country of residence, The project aims to look at the neuropsychological and education level, and comfort in using the Internet did not predict electrophysiological correlates of the 6 to 16 year old children mental health service preference. Stoicism (which was significantly diagnosed with Attention Deficit Hyperactivity Disorder after they higher among males) predicted preference for online services. were given cognitive training in comparison to the children who Implications for future research and inclusion of other variables that receive treatment as usual. may influence mental health service preference are discussed. 26. Integrated treatment for intimate partner violence and alcohol 23. Teachers’ awareness and understanding of non-suicidal self- use for heavy drinking men in South India (collaboration with injurious behaviours among students. Investigators: Dr. St John’s Research Institute). Investigators: Dr. K Srinivasan, Poornima Bhola (IRB approval obtained) Dr. Satyanarayana, VA (Funding by SBR/ICMR)
Non-suicidal self-injurious behaviour like cutting, carving or burning The aims of this study are twofold: (a) To explore perpetration skin is a growing concern among youth and rarely reaches the attention and victimization experiences of problem-drinking men and their
National Institute of Mental Health and Neuro Sciences 139| Annual Report 2014-15 wives, and (b) To examine the comparative effectiveness of standard effects of different combinations of Asha support on the health of intervention (Treatment As Usual) and enhanced intervention WLA and their oldest child (ages 3-8) will be evaluated. In addition, (Standard Plus cognitive behavioral intervention) for problem- the researchers will take advantage of rural India’s excellent mobile drinking men known to perpetrate IPV. The primary objectives are phone and computer technology coverage in both data collection to compare the effect of standard versus enhanced interventions in and data transfer. Following a formative phase, four groups in a 2x2 reducing (a) alcohol consumption among problem drinkers (b) the factorial design will be tested and will include Asha support for WLA frequency of perpetration of IPV among problem drinkers (c) the alone, vs Asha support plus nutrition training (Asha + Training) vs frequency of IPV related victimization among wives of problem Asha support for WLA plus food supplementation (Asha support + drinkers. The secondary objectives are to compare the effect of food), vs both (Asha support + Training + food) to determine the effect standard versus enhanced interventions in reducing (a) symptoms of the Asha-delivered support and nutrition interventions primarily of Depression, Anxiety and Stress among wives of problem drinkers on nutritional parameters, ART adherence and mental health of and (b) emotional and behavioral problems in children. The study is the WLA and secondarily on mental health, and psychomotor conducted in two phases: phase one, the formative phase is completed development. Baseline data has been collected on the participants and and a manuscript based on the findings has been submitted for the study intervention and follow-ups are ongoing. publication. Phase two, the intervention phase has also been completed. Data has been obtained for 120 participants and 10 per 29. Effect of Indian classical music on perceived anxiety, depth cent attrition has been noted at three month follow-up. Data analysis of anesthesia and cortisol level in patients undergoing is currently ongoing. spinal surgery: A double blind randomized controlled study. Investigators: Dr. Shantala Hegde, Dr. GS Umamaheswara 27. Effectiveness of a mental health intervention in protecting Rao, Dr. Rita Christopher, Dr. Gopala Krishna KN (Funding oneself against gender based violence and enhancing by NIMHANS, Intra-mural research grant) resilience in young adult women. Investigators: Dr. Satyanarayana, VA, Dr. Chandra PS (Funding by SBR/ Recent studies have highlighted deleterious effects of deep intra- ICMR) operative anaesthesia on postoperative outcomes. Research studies examining the effect of music on health have reported that music has The aim of the study is to examine the effectiveness of a peer beneficial effect in lowering the usage of sedative drugs, as well as in delivered group mental health intervention in protecting oneself lowering of stress levels assessed via behavioral as well as physiological against GBV and enhancing resilience in young adult women from measures in patients undergoing various kinds of surgery. In this socio economically disadvantaged backgrounds in Bangalore. The double blind randomized controlled group study, we examined the effectiveness of a peer delivered group mental health intervention on: effect of ragas of North Indian classical instrumental music (NICM) (a) Endorsing equitable gender norms (b) Increased perceived self- on perception of pain, anxiety, cortisol levels and dosage of sedative efficacy in protecting oneself against GBV (c) Increased resilience drugs and depth of anesthesia on patients subjected to a uniform (d) Reduced symptoms of depression, anxiety and stress (e) Increased technique of anesthesia during spinal surgery. Sample included gender and mental health literacy. A group randomized trial will 62 patients (n=30 in music group). Results showed that there was be conducted using a mixed methods (qualitative and quantitative) no increase in perception of pain in the music group, a significant design. PhaseI, the formative phase, has been completed. Data decrease in levels of anxiety in the music group assessed using visual through focus group discussion has been obtained for 30 participants, analogue scale as well as state trait anxiety inventory(p<0.05). There which is currently being transcribed and translated for analysis. was a significant difference between the two groups in the cortisol levels and dosage of anesthetic drug dosage consumption in both the 28. Asha improving health and nutrition of Indian women with groups between pre-surgery and post-surgery evaluation. Further AIDS and their children. Investigators: Dr. Satyanarayana studies examining the nature of musical stimuli, effect of self-selected VA, (Senior Key Personnel: Consultant), Nyamathi Adeline, music on the psychological, physiological parameters and anesthetic Sinha Sanjeev, Ekstrand Maria (Funding by NIH R01) drug dosage consumption is worth pursuing.
Utilizing the successful model employed by the Indian Government’s 30. Attachment, interpersonal sensitivity and affect regulation National Rural Health Mission to address the health needs of the in social anxiety.Ms. Selvi Kumari R. Guides: Dr. Paulomi M rural population by training Ashas, village women, to enhance health Sudhir, Dr. Seema Mehrotra. of pregnant women and their infants, a recently completed pilot study of US and Indo collaborators have demonstrated successful The study examined the role of attachment, interpersonal sensitivity improvement in ART adherence, CD4 levels and physical and mental and affect regulation in social anxiety with a sample of 360 community health among women supported by grant-trained HIV Ashas. The participants (in two steps) and 50 patients with a diagnosis of social
140 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 phobia, using a mixed method design Assessment of the community Seventeen parents participated in the evaluation stage and there was sample was done in two steps. A preliminary model was developed significant difference in parenting competence following intervention and replicated in a second sample and subsequently in a clinical based on NIMHANS parent training videos. sample. Results indicate significant differences in community and clinical samples. Path analysis indicated that reappraisal, suppression 34. Creativity and bipolar affective disorder: An fMRI study. Ms. and rumination mediated the relationship between attachment and Divya Sadana. Guides: Dr. Jamuna Rajeswaran, Dr. Sanjeev social anxiety and interpersonal sensitivity and social anxiety in all Jain, Dr. S Senthil Kumaran groups. The aim of the study was to compare Creativity and Bipolar Affective 31. Development and feasibility of a self-management Disorder using fMRI. Three group of participants—Creative Group; intervention in Type 2 Diabetes mellitus. Ms. Anisha Mary Normal Group and Bipolar Group (N=30 each) were recruited and Abraham. Guides: Dr. Paulomi M Sudhir, Dr. Ganapathi neuropsychological, personality and creativity tests were administered. Bantwal Sixty participants (20 in each group) underwent fMRI scanning in which brain activity was recorded while they performed the The study aimed at exploring felt-needfor a diabetes self-care creativity task. Results indicated that Creative Group scored highest programme and developing and testing feasibility of diabetes self- in intelligence, cognitive abilities and on openness dimension of management intervention in improving self-care, metabolic control personality followed by Normal Group and then the Bipolar Group. and quality of life in patients with Type 2 Diabetes Mellitus. fMRI results revealed higher activation of posterior areas in Bipolar Thirty eight interviews were carried out. A brief self-management Group and frontal areas in Creative Group while doing the creativity intervention (SMI) was designed. Eighty patients were recruited and task. randomized to either SMI or treatment as usual. Results of within group analysis indicated efficacy of the SMI in improving metabolic 35. Sexuality and quality of life in women survivors of breast control, quality of life and self-care. cancer. Ms. Michelle Sangeeta Barthakur. Guides: Dr. Mahendra P Sharma, Dr. SK Chaturvedi, Dr. Suraj 32. Efficacy of a school-based group coping skills program for Manjunath adolescents. Ms. Meghna Singhal. Guides: Dr. M Manjula, Dr. KJohn Vijay Sagar The objectives of the research are to study the pattern of body image issues, sexuality, marital satisfaction, anxiety, depression and overall The aim of thesis is to examine the efficacy of a school-based group quality of life in women survivors of breast cancer and to examine coping skills program for adolescents with sub-clinical depression. the relationship between these variables. Quantitative data collected As part of the pilot study, cut off scores for CDI was established, from 50 women and qualitative interviews with 15 women for those intervention module was developed and validated and examined on meeting criteria of study. Results reveal depression as predictor of a class of students. The main study included a total of 800 students quality of life; qualitative data suggests trends of good coping skills, across five schools screened. The 8-weekly intervention has been difficulties encountered with health care system, good social support carried out with students in index group (n=49) and an interactive and post-traumatic growth. Based on findings of the study contents of psycho-educatory session has been carried out with control group an intervention module have been offered. students (n=51). Post-intervention and follow-up assessments were carried out with all the students in the index and control groups. 36. A psychosocial exploration of persons seeking divorce. Ms. Suruchi Sonkar. Guides: Dr. Ahalya Raguram, Dr. BM 33. Development of parent-training videos for child behavior Suresh problems. Ms. Megha Rupa. Guides: Dr. Uma Hirisave, Dr. Jayashree Ramakrishna. Divorce is one of the most stressful life events an individual can experience. Evidence suggests that marital distress, conflict and The study aims at developing parent training videos for behavior disruption are associated with a wide range of deleterious effects problems in young children. The study was conducted in two stages. on both adults and children, on physical health and mental health Video development stage included needs assessment stage, video and well-being. The aim of the study is to explore the perceived shooting and editing sub stage. The second stage evaluated the impact causes of divorce among persons seeking divorce and examine their of the videos thus developed. At the need assessment stage, sample of mental health and psychological characteristics. These include 34 parents were recruited. Information was collected on child behavior communication, conflict resolution, social support, well-being and problems and parental stress using appropriate tools. Video shooting emotional status. The study is being carried out on persons seeking and editing sub stage involved 15 parent actors and 13 child actors. divorce who have been referred for mediation by the family courts.
National Institute of Mental Health and Neuro Sciences 141| Annual Report 2014-15
37. Integrative systemic therapy for families of youth with mental moments/processes, therapy techniques, goals, themes, therapeutic disorders. Ms. Suvarna Joshi. Guides: Dr. Ahalya Raguram, alliance, and satisfaction in individual and conjoint sessions in Dr. Mathew Varghese couple therapy. The impact of psychopathology, marital quality and differentiation is also examined using the M.I.N.I. Neuropsychiatric Family therapy attempts to understand human behavior as shaped Interview, Marital Quality Scale and Differentiation of Self by its context. Family functioning has significant implications for Inventory-Revised. Transcription of in-depth interviews, domain the development and well-being of individual members and includes coding for qualitative analysis and statistical analysis for quantitative the individual, marital and the overall family levels. However, the measures have been completed. Extraction of categories and themes relative contributions of individual or dyadic factors to overall within each domain is in progress. family functioning are not clear and have not been examined in clinical samples. This study aims to examine the impact of systemic 41. Marital therapy in couples with marital distress and sexual family therapy in families of youth with mental disorders on well- dysfunction. Ms. Manjula V. Guides: Dr. Anisha Shah, Dr. being, emotional adjustment, dyadic adjustment and overall family Manjula M satisfaction and identify predictors of the same The study aims to explore sexual interaction, sexual communication, 38. Development of a scale to assess experiences in children and marital intimacy and marital quality in 100 couples with sexual adolescents. Ms. Snigdhasree Bhattacharyya. Guides: Dr. dysfunction and also develop a new format of couple therapy for Uma Hirisave, Dr. N Janardhana those with sexual dysfunction and marital distress (through therapy with a subsample of 20). Sexual Interaction Inventory, Dyadic Sexual The aim of the study is to develop a scale to assess experiences in Communication Scale, Marital Intimacy Questionnaire, Marital children and adolescents. The study would explore how children and Quality Scale, and M.I.N.I. Neuropsychiatric Interview are being adolescents conceptualize experiences in their day-to-day lives and used for the cross-sectional sample as well as for pre-, post- and various experiences in children and adolescents. Following which a follow-up assessments of the therapy subsample. Currently, data scale will be developed to assess experiences in children and adolescents collection is progress. and psychometric properties of the scale will be established. The sample will include school going students between 8-16 years of 42. Psychological adjustment in children and adolescents age from English/Kannada medium of instruction. Qualitative and following parental loss due to road traffic accident– An quantitative methods will be used for analysis of data. The study will exploratory study. Ms Anupama Vijayaraghavan. Guides: Dr. contribute in understanding the construct of experience from the Uma Hirisave, Dr. Indira Devi. child’s perspective. The aim of the study is to explore psychological adjustment in children 39. Differentiation of self, attachment and marital quality in and adolescents who undergo parental loss due to road traffic accident. married persons. Ms. Madhurini Vallikad. Guide: Dr. Anisha The study will explore functioning in children and adolescents across Shah various domains post parental loss due to road traffic accident. The sample will consist of children and adolescents in the age group of The aim of the study is to examine differentiation of self, attachment 7-16. Qualitative and quantitative analysis will be used for analysis and marital quality in married persons. Tools used are Beck’s of data. The study will facilitate the development of a model to Depression Inventory, Marital Quality Scale, Differentiation of Self understand psychological adjustment in children and adolescents who Inventory, and Attachment Style Questionnaire. Analysis of data undergo parental loss due to road traffic accident. from a clinical sample of 105 shows that differentiation of self is associated with secure attachment and emotional reactivity is linked 43. Efficacy of mindfulness integrated cognitive therapy with insecure attachment. In the group with marital distress higher in patients with OCD. Ms. Sonal Mathur. Guides: Dr. emotional cutoff is associated with higher avoidant attachment and Mahendra P Sharma, Dr. YC Janardhan Reddy lower overall marital quality. The aim of the study is to examine the efficacy of Mindfulness 40. Client experiences in combined couples’ therapy. Ms. Integrated Cognitive Therapy (MICT) on symptom severity, Ashmeet Nagpal. Guides: Dr. Anisha Shah, Dr. Veena A beliefs about obsessions, depression, quality of life and psychological Satyanarayana flexibility in patients with obsessive compulsive disorder. A two- group design with baseline, post and follow-up assessments will The study uses a mixed-method design with 40 married individuals be adopted. Sixty patients with primary diagnosis of OCD will be to explore client experiences of helpful and unhelpful aspects, change randomly assigned to either MICT intervention group or stress
142 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 management intervention group and each group will have 15 sessions use drawn from the community will be used as a comparative group. of intervention. Appropriate statistical measures will be used to assess The findings will contribute to better understanding of the treatment the improvement and compare the two groups. needs of this clinical population.
44. Effectiveness of acceptance and commitment therapy 47. Motives, patterns and psychological outcomes of formal in patients with somatic symptom disorder. Ms. Fatema volunteering: An exploratory study. Mr. Jereesh K Elias. Khanam. Guides: Dr. Mahendra P Sharma, Dr. SK Guides: Dr. Seema Mehrotra, Dr. Paulomi Sudhir (Funding Chaturvedi by ICMR/ICSSR)
The aim of the study is to examine the effectiveness of Acceptance The study explored patterns of formal volunteering, associated and Commitment Therapy (ACT) on somatic symptoms, anxiety motives and psychosocial factors associated and documented and depression, global functioning, psychological well-being and wellbeing outcomes linked with regular formal volunteering. It used improving acceptance, mindfulness and valued-living in patients with a prospective mixed methods design. Data were collected from 83 somatic symptom disorder. A two-group design with baseline, post and prospective volunteers followed up over a six-month period and 20 follow-up assessments will be adopted. Forty patients with primary long-term volunteers. Regularity of volunteering predicted significant diagnosis of somatic symptom disorder will be randomly assigned to proportion of gains in positive affect as well as life satisfaction. Long- either ACT intervention group or treatment-as-usual group and ACT term volunteers manifested higher levels of psychological wellbeing group will have 8-10 sessions of intervention. Appropriate statistical than a matched subsample of short-term volunteers. Interviews with measures will be used to assess the improvement and compare the two long-term volunteers brought forth a rich description of multiple self- groups. reported changes as a result of volunteering experiences.
45. Cognitions, metacognitions, neuropsychological functioning 48. Social wellbeing of youth in India. Mr. Rajeev Joseph and symptom dimensionality in obsessive compulsive Michael. Guides: Dr. Seema Mehrotra, Dr. Srikala Bharath disorder. Ms. Manpreet Kaur. Guides: Dr. Mahendra P Sharma, Dr. Keshav Kumar, Dr. YC Janardhan Reddy This study explored social wellbeing, its manifestations and dimensions from the perspectives of youth. The survey has yielded OCD is a heterogeneous condition. Recent research shows one rich observations on indicators of social wellbeing in youth and such method used to reduce this heterogeneity is to examine the dimensions of social wellbeing most relevant for urban Indian symptom dimensions in OCD. It has been shown that symptom youth. A brief orientation-sensitization program for enhancing dimensions have distinct but overlapping brain substrates. There are youth engagement was developed based on focus group discussions also some early indications that symptom dimensions might have and surveys. The pilot testing has demonstrated high receptivity of distinct neuropsychological correlates. However, it is unknown that the program in youth and significant changes in social acceptance whether symptom dimensions in OCD are associated with specific dimension of social wellbeing and youth engagement as well as several dysfunctional beliefs and metacognitions. Hence, the present study behavioral indicators of gains in social wellbeing. aims to examine obsessive beliefs and metacognitions in OCD symptom dimensions and their relationship with neuropsychological 49. Positive mental health: Exploring salient dimensions and functions. developing an interview-based assessment measure. Mr. Diptarup Chowdhury. Guides: Dr. Seema Mehrotra, Dr. 46. Life adversities, relational experiences and self-esteem in Ahalya Raguram women with alcohol use disorders. Ms. Kanika Malik. Guides: Dr. LN Suman, Dr. Prabath K Chand, Dr. P Marimuthu. This is a multiphase study that aimed at identifying relevant dimensions of positive mental health through a two-step Delphi The aim of the study is to examine the clinical profile of women with method, conducting in-depth interviews to understand the lived alcohol use disorders (AUDs). It also aims to explore adverse life experiences related to various dimensions thus identified and experiences, relational factors, self-image and perceived social support subsequently developing and standardizing an interview schedule among women with alcohol use disorders. The study will use both for assessment of positive mental health. The salient positive mental quantitative measures and interview techniques to collect data. The health dimensions and indicators have been identified and their lived- sample will consist of 35 women with a primary diagnosis of alcohol experiences explored. A professional rated interview schedule has been use disorder. Interviews with a family significant other will also be developed and pilot tested. Its and inter-rater reliability, convergent carried out. A sample of 60 women without psychoactive substance validity of the same have been established.
National Institute of Mental Health and Neuro Sciences 143| Annual Report 2014-15
50. Efficacy of metacognitive therapy in patients with social 53. Development of an intervention programme for socio- anxiety disorder. Ms. Lakshmi J. Guides: Dr. Paulomi M cognitive deficits in schizophrenia spectrum disorders. Sudhir, Dr. Mahendra P Sharma, Dr. Suresh Bada Math Ms. Dhanya C. Guides: Dr. Keshav Kumar J, Dr. Jagadish Thirthahalli (Funding by ICMR-JRF) The study aims to examine efficacy of Metacognitive therapy in patients with social phobia. The control group will receive Applied Social cognition refers to the process of receiving, interpreting and Relaxation. The total sample will be 50 patients who will be assessed responding to socially relevant stimuli during interaction with on measures of Metacognition, social anxiety, post event processing conspecifics. Socio-cognitive deficits in Schizophrenia Spectrum and depression. They will receive approximately 10-12 sessions of Disorders, primarily in emotion processing, attribution bias, therapy and will be assessed at pre, post and follow-up period. Thirty socialperception, socialknowledge and theory of mind have been five patients have been recruited for the study—19 in MCT and 16 documented. However, first line treatments like psychotropic in AR group. Independent ratings of baseline, post and follow-up medications and existing psychotherapeutic interventions have not assessments are being carried out. been successful in ameliorating these socio-cognitive deficits across time. Thus arises the need for a suitable ecologically valid intervention 51. Process of change in cognitive behaviour therapy (CBT) programme for social cognition which focuses on neuropsychological and exposure therapy for social anxiety disorder. Ms. Systla perspective of the disorder. This study aims to develop such an Rukmini. Guides: Dr. Paulomi M Sudhir, Dr. A Shyam intervention programme and evaluate associated gains on measures Sundar of social cognition, neuro-cognition, social functioning and electrophysiological measures (event related potentials) on a pre- The aim of the study is to examine the role of estimated social cost, post and six-month follow up basis. A randomised controlled trial perceived social self-efficacy and perceived emotional control as will assign subjects to the experimental group (n=30) who will be mediators in Cognitive Behaviour Therapy (CBT) and Exposure compared with a patient control group (n=30) and a healthy normal therapy (ET) in patients with Social Anxiety Disorder. Fifty patients group (n=30). The study, apart from aiding in development of a with diagnosis of social anxiety will be randomized to either CBT or novel intervention programme, will also aid in furthering our current ET. Pilot phase has been completed and main phase has commenced. understanding of the relationship between neuro-cognitive functions Analysis will involve mediational analysis to examine the changes in and social cognition, and how electrophysiological markers of change, mediator variables across sessions of therapy. Weekly assessment on if any, may be identified. mediator variables will be carried out. Social anxiety and improvement will be assessed at baseline, post and follow-up assessments. 54. Emotion regulation therapy in anxiety disorders: an outcome study. Mr. Vidhya Sagar K. Guides: Dr. Manjula, Dr. Mahendra 52. Effectiveness of an integrated intervention program for P Sharma, Dr. Suresh BM (Funding by ICMR- JRF) alcoholism (IIPA): To enhance executive functions, affect regulation, and quality of life. Mr. Rajesh Kumar. Guides: The study aims to examine the efficacy of emotion regulation Dr. Keshav Kumar J, Dr. Vivek Benegal, Dr. Roopesh BN therapy in anxiety disorders (GAD, SAD & PD) in improving (Funding by ICMR- JRF) emotion regulation and reducing symptoms. In addition, mediating role of mindfulness practice and homework compliance and role of The aim of the study is to develop an Integrated Intervention moderators such as anxiety sensitivity and trait anxiety in outcome Program for alcoholism (IIPA). IIPA includes 2-3 sessions of will be examined. Sample consists of 60 participants (Intervention psychoeducation, cognitive remediation to enhance executive group- 30 and Treatment as usual group-30) with primary diagnosis functions and promote executive/cognitive control and Qigong and of one of the anxiety disorders included in the study. Intervention Tai-chi Chuan exercises to enhance self-regulation/affect regulation group will receive 16 sessions of emotion regulation therapy. Both ability. Qigong and Tai chi chuan also has health benefits. Behavioral groups will be assessed at pre, post and follow-up periods. scale, neuropsychological test and electrophysiological measure have been included in this study for base line and outcome assessment. 55. Cognitive styles, psychosocial and clinical determinants of Study has follow-up at 6 weeks after the post assessment. Tools functioning in patients with bipolar disorder. Ms. Mareena required for the study were prepared by the researcher. Eleven Susan Wesley. Guides: Dr. M Manjula, Dr. Jagdisha T tasks of cognitive remediation program were developed by the (Funding by ICMR-JRF) researcher. Qigong and some steps of Tai-chi Chuan were used in the intervention process. The data collection has been completed. The study aims to examine the cognitive styles, clinical and Data analysis and interpretation are in progress psychosocial determinants of functioning and subjective experiences
144 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 in patients with bipolar disorder. A sample of 150 patients diagnosed and aims at developing a training module on ethics in psychotherapy with bipolar disorder, fulfilling the inclusion and exclusion criteria and counselling. A survey will be conducted on 300 Mental Health will be selected for the quantitative study of which a subsample will Practitioners including MPhil trainees and PhD scholars from be drawn for in-depth interviews. A cross sectional, mixed method Clinical Psychology and Psychiatric Social Work, MDand DPM exploratory design will be used. The tools for assessments includes trainees from Psychiatry and counsellors followed by 28 in-depth socio-demographic data, MINI, brief adherence rating, young mania interviews. Relevant quantitative and qualitative analysis will be rating, Hamilton rating for depression, functioning assessment short carried out and subsequently a training module on ethics will be test, perceived stress scale, multidimensional scale of perceived social developed. The study will have implications in therapist professional support, brief cope, dysfunctional attitude scale, Rosenberg self- development. esteem scale and semi-structured interview. 59. Psychosocial aspects of children of female sex workers. Mr. 56. Brief cognitive behavior therapy in remitted bipolar disorder. Siddharth Dutt. Guides: Dr. Roopesh BN, Dr. Janardhana N Ms. Seema P Nambiar. Guides: Dr. M. Manjula, Dr. Shyam Sundar A (Funding by ICMR) The aim of the study is to explore and compare the attachment pattern, resilience and risk taking behaviour among children of female The study is being undertaken to examine the effect of brief CBT sex workers with children of single mothers and children living with on inter-episodic symptoms, dysfunctional cognitions, adherence to both the parents. The design of the study will be explorative and treatment, emotional regulation, functioning and quality of life in comparative. The quantitative methods will be used for the following remitted bipolar disorder. A two-group randomized control design variables: attachment, parenting style, resilience and just world with multiple assessments (pre, post & follow-up at three months) is beliefs, and qualitative methods will be used for following variables: planned. The sample would consist of 30 patients in the intervention risk taking behaviour, perceived stigma, attitude towards education group and 30 patients in the TAU (treatment as usual) condition in and career, peer and interpersonal relationships and role models in the age-range of 18-55 years. About 8-10 individual sessions will children of female sex workers. The implications of the study will lead be held on a weekly basis for the study group. The sample would be to development of models of providing psychosocial intervention for screened using the MINI, SCID-II, YMRS& BDI-II. these children.
57. Effectiveness of emotional competence skills programme for 60. Affective experiences, affect regulation at workplace and adolescents. Ms. Lavanya TP. Guides: Dr. M Manjula, Dr. its correlates. Ms. Janhavi Devdutt, Guides: Dr. Seema John Vijay Sagar, Dr. Mariamma Philip Mehrotra, Dr. Paulomi Sudhir (Funding by UGC)
The aim of the study is to explore emotional competence and examine This study aims at examining affective experiences, affect regulation the effectiveness of an emotional competence skills programme for at workplace and their well-being correlates. Trait affect and quality adolescents. The sample would consist of 250-300 high school and pre- of relationships at work would be examined as antecedents of affective university students in the first phase and 200 students in the second experiences. The role of interpersonal affect regulation at work would phase (Study Group=100 and Control Group=100). The inclusion also be explored. In addition to a survey of adults employed in varied criteria for both phases are students pursuing either high school or pre- organizations in the service sector, it would utilize a day reconstruction university with adequate knowledge of English. The study would adopt methodology in a smaller sample to explore the processes involved in a prospective design (pre, post and three month follow-up). positive and negative affect regulation at work.
58. Ethical beliefs and practices in psychotherapy and counseling: 61. Development and effectiveness of mindfulness integrated An exploratory study among mental health practitioners cognitive behavioral intervention for professional care and development of a training module. Ms. Ananya Sinha. providers in palliative cancer care. Ms. Amanpreet Kaur. Guides: Dr. Poornima Bhola, Dr. Ahalya Raguram, Dr. Guides: Dr. Mahendra P Sharma, Dr. SK Chaturvedi Prabha S Chandra (Funding by UGC) (Funding by UGC)
Ethical issues are often complex, multifaceted and defy simplistic 62. Development and pilot evaluation of a positive youth solutions. Despite there being ethical codes and models of ethical development program. Mr. Noufal TH. Guides: Dr. Seema decision making, mental health practitioners experience ethical Mehrotra, Dr. Pratima Murthy (Funding by UGC). dilemmas throughout their professional development. This exploratory research looks at the ethical beliefs and practices in This study protocol is in the final stage of development. It is proposed psychotherapy and counselling among mental health practitioners to explore felt needs and perspectives of the stakeholders regarding
National Institute of Mental Health and Neuro Sciences 145| Annual Report 2014-15 positive youth development program for college youth. Using this 66. Temperament, friendship quality and psychopathology data a positive youth development program would be developed .The among adolescents. Ms. Nikita Bhatti. Guide: Dr. Uma study would then examine its feasibility, receptivity and short term Hirisave outcomes. The study aimed to examine the temperament traits, quality 63. Individuation in youth: The parental perspective. Ms. Shiju of friendship and its association with psychopathology among Joseph. Guide: Dr. Ahalya Raguram adolescents. The sample consisted of 60 adolescent boys and girls, of which 30 were taken from schools and colleges and 30 from the IP/ The study aimed to understand the perspective of parents of youth OP of child and adolescent psychiatry. The results indicated there were regarding their children’s process of individuation, using qualitative differences in temperament between the two groups. However there methodology. Analysis of themes revealed that over-conforming was no difference found in the friendship quality between the two youth and vigilant parents formed a symbiotic pair which was groups. It must be noted that in the normal group, significant negative based on the knowledge of the youth’s life. Parents preferred their association was found between adolescents’ emotional problems and youth to develop ‘maturity’ that is marked by value orientation, positive peer relations. obedience, connectedness and behavioral independence rather than individuation. Separateness, emotional autonomy or value autonomy 67. A study on characteristics of couple therapy and family were not encouraged. These findings suggest that unfolding of therapy. Ms. Vasudha KG. Guide: Dr. Anisha Shah psychological processes like individuation are highly influenced by culture. This also implies that achievement of separation would be a Literature suggests that family therapy is often used for childhood challenge for youth. difficulties, schizophrenia, as well as many other severe psychiatric conditions whereas couple therapy is associated with depression, 64. Parental bonding, attachment styles and quality of sibling marital conflict, sexual difficulties and attachment issues in adulthood. relationships: An exploratory study. Ms. Shehnaaz A Ahmad. The aim of this study is to examine characteristics of couples in couple Guide: Dr. Ahalya Raguram therapy and family therapy in the Indian context. Therapy records will be coded on couples’ profiles, psychiatric morbidity, presenting The aim of the study was to explore the relationships among parental problems, structure of therapy, as well as rating on Structural Family bonding, attachment styles and quality of sibling relationships in Assessment Scale. Coding has been completed for 87 couple and youth. The sample comprised 200 college-going youth in the age family therapy cases. Further analysis is in progress. range of 17-24 years. Both paternal and maternal care had a positive correlation with warmth. Paternal care was inversely associated with 68. Beliefs, psychological impact and quality of life in men with conflict and rivalry among the siblings. Secure attachment style was sexual dysfunction. Mr. Sujith Babu. Guides: Dr. Mahendra positively correlated with warmth while insecure attachment was P Sharma, Dr. Nagaraja Rao positively correlated with conflict and rivalry. Sibling relationships were also influenced by the gender dyad of the siblings with female- The aim of the present investigation was to study the beliefs, female dyads experiencing more warmth and least rivalry. More males psychological impact and quality of life in men with sexual dysfunction. than females were found to have insecure attachments and perceived The sample consisted of 25 men with sexual dysfunction and 25 normal their mothers as exercising affectionless control. controls. The results revealed that, men with sexual dysfunction have negative stereotypes about sexuality, poorer sexual knowledge and 65. Group narrative counseling for adolescents: An explorative more conservative sexual attitudes in comparison to normal controls. study. Ms. Meenakshi Banerjee. Guide: Dr. Uma Hirisave Men with sexual dysfunction experience higher levels of anxiety and depression, and sexual dysfunction have negative psychological impact The study aims to explore the usefulness of group narrative counseling and adversely affect quality of life. Some of the stereotyped beliefs with adolescents in the school setting. A total of 187 adolescents were negatively correlated with some domains of quality of life. (divided into 6 groups) were seen for interventions. The tests used were semi-structured interview schedule and the qualitative analysis 69. Effectiveness of mindfulness integrated cognitive therapy of the feedback of the participants would be carried out. Thematic in adolescents with obsessive compulsive disorder (OCD). analysis was used to arrive at prominent themes. The results of the Mr. Shalini Mathew. Guides: Dr. Mahendra P Sharma, Dr. study indicate that the sessions were useful in terms of helping them Shobha Srinath. recognize strengths and resources and to arrive at better strategies for dealing with obstacles. They felt more certain about reaching their The aim of the present study was to examine the effectiveness of goals. mindfulness integrated cognitive therapy (MICT) in adolescents
146 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 with obsessive compulsive disorder (OCD). The sample consisted of patients with emotional disorders and 32 non-clinical participants. five adolescents fulfilling the specific inclusion and exclusion criteria The participants were assessed on Personal Feelings Questionnaire-2, for the study. A single case design with pre and post assessment Test of Self-Conscious Affect-3 (TOSCA -3) Interpersonal was adopted. Assessments were made on the measures of symptom Sensitivity Measure, Cognitive Emotion Regulation Questionnaire, severity of OCD, beliefs and thought-action fusion, mindfulness Rosenberg Self-Esteem Scale, Beck Depression Inventory – II. skills and quality of life. The results reveal that MICT is efficacious in Clinical group had higher levels of proneness to shame, significantly reducing the severity of symptoms, obsessive compulsive beliefs and greater levels of interpersonal awareness, separation anxiety, fragile thought-action fusion and in improving mindfulness skills and quality inner self, greater depression and lower self-esteem. They used more of life in adolescents with OCD. self-blame, rumination, catastrophizing, other-blame, less of refocus on planning, positive reappraisal, putting into perspective. Guilt, 70. Smoking motives, perceived consequences and motivation to interpersonal sensitivity predicted self-esteem. quit among men with common mental disorders. Ms. Arathy VS. Guides: Dr. LN Suman 73. Emotion recognition, emotion awareness, metacognition and social functioning in schizophrenia. Ms. Radhika K. The aim of the study was to examine the smoking motives, perceived Guides: Dr. Paulomi M Sudhir, Dr. Jagadisha consequences and motivation to quit smoking among men with common mental disorders (CMDs). The sample consisted of two The study examined emotion recognition, awareness, metacognitive groups. Group I: 30 male smokers with CMD; Group II: 30 male processes, social functioning in 27 patients with schizophrenia (SZ), smokers without psychological problems. Results revealed that 50 per and 26 non-clinical controls. Patients were assessed on Scale for cent in Group I had high nicotine dependence as compared to 23 Assessment of Positive Symptoms (SAPS), Scale for Assessment per cent in Group II. Group I subjects had higher craving and poor of Negative Symptoms (SANS), Tool for Recognition of Emotions control over number of cigarettes smoked and were more concerned in Neuropsychiatric Disorders (TRENDS), Toronto Alexithymia about the impact of smoking on their health. However, only 10 Scale (TAS), abbreviated version of Metacognitive Assessment per cent of the subjects in Group I was in the preparation stage of Scale, self-reflectivity of Beck’s Cognitive Insight Scale (BCI) and quitting as compared to 20 per cent of the subjects in Group II. The Groningen’s Social Dysfunction Scale (GSDS).Patients with SZ findings have implications for tobacco cessation programs for men had greater emotion recognition deficits. Emotion recognition, with CMDs. awareness, metacognition were not significantly correlated with each other. Marital status was a significant predictor of social 71. Exposure to violence and victimization experiences among functioning. juvenile boys in conflict with the law. Ms. Atulya Gurha. Guide: Dr. LN Suman 74. Effect of aging on cognitive functions and quality of life. Ms. Apoorva B. Guides: Dr. Keshav Kumar J, Dr. Srikala Barath, The aim of the study was to examine exposure to violence and Dr. P Marimuthu (NIMHANS Intramural Funding) victimization experiences of juvenile boys in conflict with the law. The sample consisted of 25 boys in the age range of 14 to 20 years The study examined the effect of gender and education on cognitive housed in the Observation Home. Results revealed that a majority functions and their relationship with quality of life in Indian elderly. of the crimes committed were those against persons, particularly Their sample consisted of 90 healthy normal men and women who homicides or assaults. 41 per cent reported that other family members were above 65 years of age. had been involved in antisocial and criminal activities. Victimisation experiences were mostly due to exposure to domestic problems, verbal The results showed that there significant gender difference on tests of abuse by the father and community violence. Majority of the boys were fluency and planning. Participants with higher education performed from broken homes, had poor to average scholastic performance and better on tests of working memory, learning and memory, fluency and were associated with antisocial peers. The findings have implications planning. Quality of life decrease with increase in age but there were no for psychosocial interventions with this vulnerable population. difference between males and few males on quality. The implications and strengths of the study as well as limitations have been discussed, 72. Self-conscious emotions, cognitive emotion regulation and with respect to findings and relevant literature. interpersonal sensitivity in emotional disorders. Ms. Preethi A Ninan. Guide: Dr. Paulomi M Sudhir 75. Differential performance on neuropsychological tests in left and right mesial temporal sclerosis. Mr. Harishankar Study examined shame, guilt interpersonal sensitivity, cognitive Moosath. Guides: Dr. Keshav Kumar J, Dr. Sanjib Sinha, Dr. emotion regulation strategies self-esteem and depression, in 32 P. Marimuthu (NIMHANS Intramural Funding)
National Institute of Mental Health and Neuro Sciences 147| Annual Report 2014-15
The study examined the sensitivity and specificity of commonly with future time orientation in romantic relationships of young used neuropsychological test in distinguishing between left and adults. With a cross-sectional mixed method exploratory design and right mesial temporal lobe epilepsy (MTLE) group. The sample purposive sampling, the study was conducted in two phases. In phase consisted of 16 right MTLE and 14 left MTLE patients. The results one, semi-structured interviews were used to prepare a checklist for revealed that the performance of two groups significantly differed on exploring experiences in romantic relationships. In phase two, 344 immediate recall and recognition, immediate recall logical memory, unmarried participants responded to the socio-demographic data verbal memory delayed recall, visual learning and memory on both sheet, the checklist, Young Schema Questionnaire- S3, Differentiation immediate and delayed recall and visual reproduction. A discriminant of Self Inventory- R and Future Time Orientation in Romantic function analysis revealed that verbal recognition and delayed recall Relationships. Content analysis, descriptive statistics, chi-square, were most sensitive in differentiating between left and right MTLE t-tests, ANOVA, correlation coefficients and multiple regressions groups. were employed for analysis.
76. Exploration of technology use among psychiatric population. 79. Experiences of bullying, body self-esteem and psychological Ms. Aswathy Das. Guide: Dr. Manoj K Sharma functioning in young adults. Ms. Kangkana Bhuyan. Guide: Dr. M Manjula There is dearth of information about the pattern of technology use among the psychiatric population as well as its relationship with other The aim of the present study was to explore experiences of bullying, socio- demographic variables. A total of 75 subjects were assessed body esteem and psychological functioning in young adults. The using Internet Addiction Impairment Index, Video Game use sample consisted of 311 students, both males and females. They were patterns, Pornography Addiction Screening Tool, ADHD Adult Self assessed on Body Esteem Scale, Retrospective Bullying Questionnaire Rating Scale and Screening for mobile phone use. Results indicate and Adult Self Report. that the mean age of the sample was 26.67 with the standard deviation of 6.5. The age distribution was 16 to 40 years. Presence of addiction Overall findings suggest that people with bullying experiences tend to had mobile phone (14/75; 18.67%), internet addiction (21/75; 28%), have more psychological problems compared to people who have no pornography (14/75; 18.67%) and video games (11/75; 14.67%). It experiences of bullying. No statistically significant difference was seen has implication on screening and educating them for healthy use of for Body Esteem Scores with respect to prior experiences of bullying. technology. On the other hand people who were in the clinical and borderline level of psychological symptoms had lower scores for body esteem. 77. Defensive pessimism, perceived stress, coping and psychological functioning in youth. Ms. Asha Ravi. Guide: 80. Status of prospective memory and working memory in Dr. M Manjula the first degree relatives of schizophrenia patients. Ms. Saima Saleem. Guides: Dr. Devvarta Kumar, Dr. G The aim of the present study was to examine defensive pessimism, Venkatsubramanian (NIMHANS Intramural Funding) coping and psychological functioning among youth and also to examine the relationship between the variables. The sample consisted of 200 The study has been done to see the endophenotypic value of students. The study was conducted in two phases. Phase-1 aimed at prospective memory and working memory in schizophrenia. The finding out the reliability and validity of defensive pessimism scale and sample consisted of 20 schizophrenia patients (SCZ), enrolled from Phase-2 focused on the main study. The participants were assessed on the inpatient and outpatient service of NIMHANS, 20 unaffected Defensive Pessimism Questionnaire, Cohen’s Perceived Stress Scale, first degree relatives of schizophrenia patients (FDR), and 20 healthy Proactive Coping Inventory, Rosenberg Self Esteem Scale and Adult controls (HC). Findings reveal that event-based prospective memory Self Report. The DPQ has significantly high test retest reliability can be an endophenotype of schizophrenia. (0.834). Defensive pessimism had high correlation with perceived stress and proactive, preventive, reflective, and strategic coping. 81. Social cognition and attachment in individuals with emotionally unstable personality disorder. Ms. Anupama V. 78. Romantic relationships, self-schemas and differentiation Guides: Dr. Poornima Bhola, Dr. Jagadisha Thirthalli of self in relation with future time orientation in romantic relationships of young adults. Ms. Priyanka Mittal. Guide: The study examined attachment, mentalisation and social cognition, Dr. M Manjula in individuals diagnosed with Emotionally Unstable Personality Disorder (EUPD). The sample comprised of 20 individuals with The aim of the study was to explore experiences of romantic EUPD and 20 normal controls. The tools administered included The relationships, self-schemas and differentiation of self in relation Attachment Style Questionnaire, Mentalisation Questionnaire, The
148 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Reading the Mind in the Eyes Test and Social Cognition Rating Tool The study aimed at assessing musical deficits and examining its relation in Indian Setting (SOCRATIS). Analysis indicated that individuals with cognitive functions, emotion recognition, and psychopathology with EUPD had significantly levels of anxious attachment, lower in patients with schizophrenia (SZ). The study included patients with mentalising ability and lower facial emotion recognition. On the schizophrenia (SZ) and age and education matched healthy controls SOCRATIS, the clinical group had significantly higher personalizing (HC) (n=26 in each group). Psychopathology and disability were bias and greater difficulties in understanding, reacting to social assessed using scales; cognitive abilities, psychopathology, levels of situations and detecting subtle social cues. disability, musical deficits and emotion recognition was assessed using standardised tools. SZ had global deficits in cognitive functioning, with 82. Employers’ attitudes towards employing and working with higher difficulties in verbal, visual learning and memory. The two groups people with mental illness. Ms. Haleemunissa S. Guides: Dr. differed significantly on music tests of rhythm perception and incidental Poornima Bhola, Dr. SK Chaturvedi memory. SZ showed significant impairment in accurately identifying emotions and significant under-identification of emotions. Musical The study explored employer attitudes towards hiring and working abilities, multiple cognitive functions and emotion recognition were with persons with mental illness. The sample included 65 employers highly correlated. Rhythm perception predicted verbal working memory, from sales, hospitality, IT and manufacturing sectors. Results indicated music memory predicted verbal memory, melodic and rhythm perception highest levels of concern about violent or unusual/bizarre behavior. predicted emotion recognition. Musical deficits are correlated with There were both positive and negative attitudes towards mental cognitive functions, emotion recognition and negative psychopathology. illness. The majority reported low levels of contact with persons with Future studies with larger sample size may throw further light on the mental illness. Rates of mental health concerns among employees were role of musical deficits in affecting global functioning. underestimated and most favoured disclosure of illness. The analysis examined relationships between years of experiences and employer 85. Pathways-to-care, awareness about child psychiatric attitudes, relationships between attitudes towards mental illness, level conditions and expectations from mental health of contact and hiring attitudes. Qualitative analysis indicated the most professionals. Ms. Aakriti Malik. Guides: Dr. Roopesh BN, favourable response to depression followed by psychosis and then Dr. John Vijayasagar alcohol dependence. The study aimed at exploring the pathways-to-care, parent and their 83. Dating violence in young adults: an exploratory study. Ms. respective child’s awareness about the child’s psychiatric condition Cassandra Sundaraja. Guide: Dr. Veena Satyanarayana and their expectations from the mental health professionals. The findings revealed more than half of the parents to be unaware of The current study explored dating violence in the Indian context, child’s psychiatric conditions. Pathways- to- care revealed majority and its relationship to attachment styles and mental health. A mixed- of patients to have visited a general hospital before coming to method research design was adopted, integrating both quantitative and NIMHANS. Additionally, the major sources of referral to child and qualitative methods of investigation. Seventy-five undergraduate and adolescent psychiatry OPD were the general physicians, paediatricians, post-graduate students of a Bangalore-based university, who were in a friends and relatives. Expectations of the children from mental health heterosexual romantic relationship that had lasted a minimum of three professionals included getting an appropriate treatment and knowing months, participated in the quantitative study (Part I). The qualitative the reason for their illness. Majority children reported not being aware study (Parts II and III) was carried out concurrently, where five women of their difficulties from Part I who either reported no violence on the CTS2 participated in a focus group discussion (Part II), and ten individuals who reported 86. Self-concept, psychological well-being and personal dating violence on the CTS2 were interviewed in-depth about their experiences among adolescents with mild mental retardation. experiences (Part III).Results indicated that the rates of dating violence Ms. Mridul Kataria. Guide: Dr. Roopesh BN, Dr. John in India are comparable to those reported by Western literature, with Vijayasagar a predominance of bidirectional violence across all types of violence. Regression analysis implicated childhood emotional abuse, younger The aim of the study was to explore the self-concept, psychological age, perpetration of bullying, having been away from home during well-being and personal experiences among adolescents with Mild childhood and current substance use as predictors accounting for about Mental Retardation. The sample comprised of 19 MMR and 19 forty-one percent of the variability in the scores of dating violence. Typically Developing Adolescents. Results showed that there was no significant difference between the MMR and TDA group for self- 84. Evaluation of musical rhythm discrimination ability in concept and psychological well-being. Fifty-eight percent of MMR patients with Parkinson’s disease. Ms. Amrita Biswas. group reported feeling discriminated and thirty seven percent of them Guides: Dr. Shantala Hegde, Dr. Pramod Kumar Pal. reported as feeling different from their peer group. The study shows
National Institute of Mental Health and Neuro Sciences 149| Annual Report 2014-15 that proper caring, going to usual school, friends and play might have through district youth empowerment centres in Karnataka. A impact on the self-concept and the psychological wellbeing in mild certified training module for master trainers’ in behavioural, mental, mentally retarded children. physical, emotional, environmental, educational, personality, family and relational issues of youth and their parents will be developed in the project followed by training of training of 50 Yuva Parivarthakas Epidemiology and about 250 Yuva Mithras to provide services. District level Youth Empowerment Centres will be established to provide guidance and 1. Monitoring and evaluation of road safety – 10 India project. support services related to youth behavioural, mental and psychosocial Investigator: Dr. Gururaj G ( Johns Hopkins University, issues. The project is being implemented in Kolar, Chikkaballapura, USA) Bangalore, Mysore, Mangalore, Davanagere, Chikkamagalur, Gulbarga, Belgaum, and Bagalkot districts. This project is being undertaken in the two districts of Andhra Pradesh Viz. Hyderabad and Visakhapatnam in collaboration with 5. National mental health survey, Kolar pilot study. International Injury Research Unit of the Johns Hopkins University Investigators: Dr. Gururaj G, Dr. Girish N, Dr. Pradeep BS with support from Bloomberg Philanthropies. Under the project, data (Funding by MH&FW, Govt. of India) collection at a population level on use of helmets and drink driving are undertaken and the department provides monitoring, evaluation and Mental, Neurological and Substance Use Disorders (MNS) are data management support for the programme. Several rounds of data increasing in India. The number of Indians affected with MNS were collected during the year from both the cities. disorders is not clearly known and the available estimates are based on data that is more than two decades old. The national survey proposes 2. Analysis of highway crashes and determinants in Kolar to estimate true burden of mental health problems in a representative district. Investigator: Dr. G Gururaj (Funding by Road population and provide a framework for evaluating the impact of Traffic Injury Network (RTIN) DMHP. The objectives of the pilot study in Kolar district are to understand the feasibility of the sampling design adopted for the This project is undertaken with the support from Road Traffic Injury National Mental Health Survey, identify challenges and operational Research Network of the World Bank Global Road Safety Facility to feasibility of the proposed study methodology including use of MINI identify and analyze the characteristics, patterns and determinants of instrument. It would provide estimates of prevalence of different road crashes on highways in an Indian district viz. Kolar. During the mental health problems in the district of Kolar and also regarding year, data collection was undertaken from police and hospital sources feasibility of using a handheld device for data collection. in the district to understand the crash patterns and outcomes on highways traversing through the district. 6. Pilot Study on youth mental health behavior survey in Bangalore: Phase 1-Development of methodology and 3. Adolescent and youth health survey at Himachal Pradesh. questionnaire validation. Investigators: Dr. Sunitha Singh, Investigators: Dr. G Gururaj, Dr. Pradeep BS (Funding by Dr. Gururaj G (NIMHANS Intramural Funding) National Rural Health Mission – Himachal Pradesh) The project is initiated with an objective to develop and validate This is a representative statewide survey to generalize health problems appropriate and culture specific study instrument(s) to understand among the youth (10-24 years) in Himachal Pradesh. The survey and quantify mental health behaviors including substance use was completed in July 2014. A total of 2895 youth participated in disorders and injuries among youth aged 16 to 30 years in Bangalore the quantitative survey and the qualitative component of the survey adopting quantitative and qualitative research methodologies on a constituted about 15 focus group discussions among youth in the state sample of 1900 youths from educational institutions, workplaces of Himachal Pradesh. and slums coming under BBMP wards. The outcomes of the study include validation of study instrument and generating evidence on 4. Developing and implementing mental health promotion perceptions and patterns of mental disorders including substance use services for youth in Karnataka – Project Yuva Spandana. disorders and injuries among youth and stakeholders. Investigators: Dr. G Gururaj, Dr. Pradeep BS, Dr. Seema Mehrotra (Funding by Department of Youth Empowerment 7. Assessment of perceived needs and barriers for care among and Sports, Govt. of Karnataka) patients with Stroke and unipolar depression. Investigators: Dr. Gautham MS, Dr. Girish B Kulkarni, Dr. Santosh The project seeks to develop and implement an integrated Loganathan, Dr. Gururaj G (NIMHANS Intramural behavioural, mental and psychosocial support services for the youth Funding)
150 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Evidence regarding type of perceived needs and barriers experienced impact and stigma related barriers in help seeking, sociocultural by patients with stroke and depression will be useful to bridge factors was collected through quantitative and qualitative approach. treatment gap, improve disease outcomes and enhance quality of Data collection has been completed. The study is expected to provide life. Hence, a hospital based cross sectional study with a community- essential evidence for strengthening the public health approach in tracing sub component, is conducted to assess the perceived needs and overcoming the stigma and related barriers to improve the mental barriers for care among a convenient sample of patients with stroke health services utilization, which can be utilized for stigma and depression. The study will help in need based re-organization of reduction interventions in Kolar. service delivery and shorten treatment gap. Data collection and data analysis has been completed and the report is being developed. 11. Developing a model and framework for training ASHAs in mental health. Investigators: Dr. Senthil Amudhan R, Dr. 8. Health and work productivity: A retrospective record analysis Jagadeesh M, Dr. Girish N in TKMPL limited. Investigators: Dr. Gautham MS, Dr. Pradeep BS, Dr. Kowshik Kupatira, Dr. Gururaj G (Funding With the objective of enhancing the capacity of ASHAs in delivering by Toyota Kirloskar Motor Private Limited) mental health care in the community, the research has developed a mental health training manual for ASHA through a systematic and India with a workforce of nearly 300-400 million has limited studies robust scientific procedure. “IRIS” model and life course framework to ascertain the impact of health on work productivity. This five-year was developed and adopted. A training programme was organized retrospective record analysis of work cohort in TKMPL is expected for 70 ASHAs in Kolar taluk based on the training manual. The to provide vital evidence regarding relationship between health and study demonstrated the effectiveness of the training programme in productivity. This study aims to understand the existing quantum of enhancing the mental health literacy of ASHAs for the priority mental mental health and NCD problems among workers and subsequently health disorder. IRIS model was found to simplify the complex issues help in their integration. in mental health. The life course framework along with the “IRIS” model aligned the mental health training needs with national mental 9. Integrating common mental disorder, work stress and health priorities and appears to be more appropriate for reducing the behavioral risk factor screening in industrial health systems mental health burden in low-income countries with limited resources. in HONDA motorcycles and scooters India Pvt. Limited, Kolar. Investigators: Dr. Gautham MS, Dr. Desmond Rego, 12. Community follow-up study of Parkinsonism patients Dr. Gururaj G seen at NIMHANS. Investigators: Dr. Vivek Gupta, Dr. G Gururaj, Dr. Pramod Pal, Dr. Ravi Yadav (NIMHANS Screening for common mental disorders like depression, anxiety and Intramural Funding) important behavioral risk factors for NCDs is not integrated into annual medical examination in HMSI, Kolar. This pilot endeavour Parkinsonism is recognized as one of the major causes of disability seeks to facilitate the process integration of screening for NCD risk especially in the geriatric age group. While the epidemiology of factors, psychological distress, depression and work stress in annual Parkinsonism in India has been studied in terms of its prevalence and medical examination of workers in HMSI, Kolar. risk factors, literature on health seeking patterns of patients, disease progression and mortality among patients and the burden among 10. Stigma experience and related barriers of help-seeking in caregivers of patients is unfortunately lacking. A follow-up study of psychosis, depressive disorders and alcohol use disorders: a patients with Parkinsonism seen at NIMHANS OPD was conducted hospital based exploratory study. Investigators: Dr. Senthil adopting a community-based longitudinal follow-up design, to study Amudhan R, Dr. Girish, Dr. Santosh Loganathan, Dr. Arun the patterns and motivations for health seeking among these patients. K (NIMHANS Intramural Funding) The survival patterns and caregiver burden was analyzed.
Stigma associated with mental illness act as a significant barrier to 13. Assessment of drug logistics for management of access mental health care and resulting in poor outcomes due to neuropsychiatric disorders in public health facilities of Kolar mental illness. In India, research related to mental health stigma is district. Dr. Vasanth Kumar DE. Guide: Dr. Girish N Rao very limited. The critical role of stigma in help-seeking is also not well documented. This study aims to generate evidence on stigma This study was conducted among public health facilities of Kolar to and related barriers of help seeking among schizophrenia, depressive document and describe the existing drug logistics for neuropsychiatric disorders and alcohol use disorders. A sample of patients and their care disorders by records review and Key Informant Interaction (KII) givers attending the OPD services of NIMHANS were enrolled and methods. Indenting, procurement, supply and distribution were information on stigma experience, coping mechanisms, psychosocial analyzed for neuropsychiatric drug logistics. The review observed
National Institute of Mental Health and Neuro Sciences 151| Annual Report 2014-15 inappropriate and incomplete indenting, inadequate supply, < 0.001). Training course improved participants’ ability to recognize deficiencies in maintenance of records, problems in storage of a mental disorder. neuropsychiatric drugs including lack of training of health personnel to manage neuropsychiatric problems. 16. Compliance to cigarettes and other tobacco products Act (COTPA) section 4 in public places of South Bengaluru, BBMP. A descriptive study. Dr. Kumar MV. Guide: Dr. Pradeep BS
A study was undertaken to evaluate the compliance to COTPA section-4, in 359 randomly selected public places in Bangalore south BBMP. In addition, interview with the Persons Responsible for Compliance (PRC) of the Act and Enforcement officers (EO) responsible for enforcement of COTPA 2003 was undertaken to assess awareness about the act. Few places had low compliance (1.9 per cent), while 28 per cent partially complied. Majority of PRC and EO were aware of COTPA. However, they lacked information on provisions of the Act. Low compliance coupled with lack of awareness demands a comprehensive strategy to enhance awareness among PRC and EO about the Act. 14. Assessment of occupational health systems and services in Industries in Kolar with specific focus on mental health. Dr. Smita Rawat. Guides: Dr. Gautham MS, Dr. Gururaj G Human Genetics
This cross sectional study was conducted to assess the status of 1. Understanding the Th17 cytokine-mediated pathogenesis occupational health systems and services among a random sample of of Guillain Barré Syndrome: An integrative biochemical, industries in Kolar, with specific focus on assessing systems for mental genetic and gene expression study. Investigators: Dr. Monojit health care. Health systems and services were better in hazardous Debnath, Dr. Madhu Nagappa, Dr. Arun B Taly (Funding by industries. Pre placement and periodical health examination was DST-SERB, New Delhi) conducted in 38 per cent and 35 per cent of industries respectively. Occupational health systems and services for prevention, control and Guillain Barré Syndrome (GBS) is an immune mediated acute management of mental health were virtually non-existent. There is inflammatory disorder in the peripheral nervous system. In this study, a need to look beyond health related provisions of Indian Factories the investigators have adopted an integrative approach to investigate Act for initiating and strengthening mental health programme in the role of Th17-mediated immune attack in GBS by studying the industries. impact of activating and antagonizing cytokines such as IL-23, IL- 10 and IL-27 on Th17 cells based on expression of transcription 15. Development and feasibility of mental health training factors (RORc and STAT3) and its signature cytokine, IL-17. In programme for ASHA in Kolar Taluka, Karnataka. Dr. addition, genetic variation of the genes related to Th17-signaling Jagadeesh M Guides: Dr. Senthil Amudhan R will be examined to understand whether such genes play any role in determining genetic predisposition to GBS. For effective integration of mental health into primary health care, there is a need for non-specialist health workers to acquire relevant 2. Genetic and expression studies of HLA-G and cytokines knowledge and skills in mental health. ASHA being the direct link to evaluate the immune-mediated risk of schizophrenia. between the community and health system have different training Investigators: Dr. Monojit Debnath, Dr. Ganesan needs as compared to other non-specialist health workers. This Venkatasubramanian (NIMHANS Intramural Funding) study was conducted in two stages: (i) Development of manual: a manual was developed using IRIS model and life course framework Immune dysfunction has consistently been linked to schizophrenia on priority mental disorders. (2) Training and Evaluation: A one-day pathogenesis. Prenatal immune dysregulation due to environmental mental health training programme was conducted using the developed adversities affects crucial phases of neurodevelopment and enhances manual and was evaluated using pre-test and post-test study design. the risk of schizophrenia in the offspring. HLA-G with its There was strong evidence of improvement in the participants’ predominant expression at the feto-maternal interface acts as crucial knowledge and belief about mental health problems after training (p anti-inflammatory and tolerogenic molecules. However, altered
152 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 expression of HLA-G due to genetic variation and environmental modification will be useful in prognosis of glioma. In this project, the adversities can disrupt the tolerogenic attributes of HLA-G and investigators are considering the correlation of alterations in both lead to secondary complications through immune activation. To gain genes with the clinical data. So these genes can be considered as good primary insights into the role of HLA-G in schizophrenia, the levels prognostic and diagnostic markers in glioma especially in the Indian of sHLA-G and the impact of 14 bp INDEL polymorphism on population. sHLA-G levels were evaluated. The 14 bp INDEL polymorphism was studied by PCR amplification/sequencing and plasma levels of 5. Role of gene polymorphisms and epigenetics in aneurysmal sHLA-G was detected by ELISA. subarachnoid haemorrhage. Investigators: Ms. Arati Suvatha, Dr. Chetan GK (Funding by DST, Women A significantly low level of sHLA-G was observed in schizophrenia Scientist Programme) patients, indicating that this could possibly contribute to chronic low-grade inflammation in schizophrenia by activating inflammatory Subarachnoid haemorrhage (SAH) is a pathological condition cascades. Additionally, a significant positive correlation between the analyzed by bleeding into the subarachnoid space which is the area levels of sHLA-G and early age at onset of schizophrenia symptoms between the arachnoid membrane and the pia mater surrounding the in males was found, implying possible implications of HLA-G in brain. SAH is mainly caused by three reasons, rupture of a cerebral immune-mediated neurodevelopmental abnormality. arterial aneurysm, an arterial-venous malformation, or a head trauma. Risk factors of aneurysmal subarachnoid haemorrhage (aSAH) include 3. The immuno-psychiatry in South India study (IPS)- hypertension, smoking and heavy alcohol intake. aSAH is common immunogenetic and immuno-phenotype characterization in Indian population with less chances of recovery. The main reason of major psychoses.Investigators: Prof. Vir Singh Negi, for poor recovery is the delayed cerebral ischemia and vasospasm. JIPMER, Prof. MA Vijayalakshmi, VIT, Dr. Monojit Though there is surgical and medical progress, the treatment of aSAH Debnath (Funding by Indo-French Centre for the Promotion remains unpredictable and cause high rate of mortality. In this study, of Advanced Research) we focus on polymorphisms in key genes and its association with the occurrence and outcome in aneurysmal subarachnoid haemorrhage In this study, the nature and extent of immune dysregulation in (aSAH). The investigators are analyzing the role of polymorphisms in schizophrenia and bipolar disorder in two geographically distinct Apolipoprotein E, Factor XIII and BDNF gene and methylations in population groups (French Caucasians and South Indians) factor XIII and BDNF gene and its impact on the risk and outcome of encountering distinct environmental factors are being investigated. the SAH. Although the significance of ApoE, Factor XIII and BDNF This will provide insights into the genetic and biological heterogeneity genes has been studied in various neurological disorders, studies in of these disorders within and across the studied population-groups, aSAH are rare. Prime focus is on the role of gene polymorphisms and immunogenetic basis of associated auto-immunity, and environmental epigenetics factors along with clinical parameters in the occurrence influences on Human Endogenous Retroviruses-W family in and outcome of aSAH. establishing the disease and in relapsing episodes. 6. Effect of growth factors and wound healing in diabetic animal 4. Expression and regulation of p16 and Bmi1 genes in Human model. Investigator: Dr. R Gope Glioma Progression. Investigators: Dr. Chetan GK, Dr. Dhananjaya I Bhat (Funding by SERB, DST, India) Previously the investigators have shown that the topically applied growth factors accelerated cutaneous wound healing process in Glioma is a broad category of brain tumors that come from glial mice mode. They also analysed the effect various concentrations cells. It is the most common primary malignant neoplasm of the and combinations of the growth factors on the cutaneous wound central nervous system. Many mutations occur frequently in genes repair process. In the current project, the effect of growth factors that control cell cycle and proliferation leading to tumor progression. on the wound healing was analysed using diabetic mice model. The The understanding of the role of Bmi1, oncogene and p16, tumor preliminary data indicates that the diabetic wound healing can be suppressor gene in diagnosis of glioma, especially at the transcriptional achieved by using combinations of certain growth factors and small level is in infant stage. Gene alteration studies of both genes will be molecules in a time bound manner. helpful for the diagnostic and therapeutic purposes. Main alterations in p16 gene include mutations and transcriptional regulations and 7. Analysis of RB1 and p53 gene products in human brain/ deletions in one of the exons. Aberrant methylation of p16 in gene in nervous system tumors. Investigator: Dr. R Gope serum can be an early diagnostic tool in glioma. Analysis of p16 SNPs in Indian population may help to develop personalized medicine. Previously, the investigators reported structural changes (LOH) at the Bmi1 gene amplification and transcriptional and post transcriptional intron 1 loci of RB1 and p53 genes in the human brain and nervous
National Institute of Mental Health and Neuro Sciences 153| Annual Report 2014-15 system tumors. The regulations of these genes, when not altered at evaluated. In addition, relationships between the immunogenetic the structural/ expression levels, appears to be at the protein level, that parameters and dermatoglyphic profile are also being examined in is, at the level of post translational modifications (PTMs) of these schizophrenia patients. proteins. Effect of small molecules on the PTMs of pRb and p53 protein is being assessed. Preliminary data indicates that the observed 11. Prognostic and predictive significance of p16 and Bmi1 genes cell death of NF2 tumor cells caused by the small molecules in vitro in human glioma. Mr. Sibin MK. Guides: Dr. Chetan GK, is p53 mediated. Further studies are being carried out to assess the Dr. Dhananjaya I Bhat (Funding by CSIR, India) effect of small molecules on the PTMs status of pRb and p53 in the primary cultures of human brain tumor cells in vitro. The investigators studied 50 glioma patients and their molecular characterization using two major genes p16 and BMI1. Exon-wise 8. Effect of aluminum on the p53 gene expression in mouse deletion status analysis of p16 gene from Indian population showed brain. Investigator: Dr. R Gope varied pattern of deletion in all three exons. P16 mutation is a rare phenomenon and its frequency is 4.2 per cent in Indian population. Aluminum is known to cause changes in animal and human brain p16 mRNA and protein under expression and Bmi1 mRNA and cells. However, the details regarding the effect of aluminum on the protein over expression is common in glioma and it was grade specific. gene expression in the brain cells is still unclear. In this study, effect There is correlation between Bmi1 and p16 mRNA expression. There of aluminum on the gene expression, specifically p53 gene expression was no Bmi1 copy number variation in our glioma patient samples. will be analysed. Clinical markers like KPS, midline shift and tumor type could predict the OS and PFS and age of the patient can only predict OS. P16 9. Immunogenetic investigations of Interleukin-6 (IL-6) deletion can predict the PFS in glioma patients and p16 mRNA abnormalities in Schizophrenia. Ms. Deepthi Venugopal. expression could predict both OS and PFS. P16 protein expression Guides: Dr. Monojit Debnath, Dr. Venkatasubramanian can only predict OS. Bmi1 mRNA expression could predict PFS, but Ganesan, Dr. Moinak Banerjee, RGCB, Trivandrum protein expression couldn’t predict patient survival. In multivariate (Funding by UGC) analysis, KPS and tumor type independently predicted the OS and PFS. P16 mRNA levels can independently act as a prognostic marker A spectrum of immunological abnormalities has been implicated to predict OS and Bmi1 mRNA levels can independently act as in schizophrenia. Interleukin-6 (IL-6), a pleiotropic cytokine, is prognostic marker of PFS. an important candidate in neuropsychiatric disorders because of its significant role not only in immune-inflammatory pathways but also 12. Study on the influence of O-6-methylguanine-DNA in neurodevelopment and central nervous system (CNS) functions. methyltransferase (MGMT) gene on downstream DNA In this study, the influence of genetic, gene expression and epigenetic mismatch repair genes in Human high grade malignant changes of IL-6 gene on the risk and progression of schizophrenia Glioma. Mr. Jeru Manoj. Guides: Dr. Chetan GK, Dr. are being examined. In addition, the status of anti-alpha7 nicotinic Narasinga Rao (Funding by UGC- Maulana Azad National acetylcholine receptor (alpha7nAChR) antibody and the interaction Foundation, UGC, India). between IL-6 mediated inflammatory and cholinergic anti- inflammatory pathway will be investigated in schizophrenia patients. DNA is susceptible to damage from cellular stress and external sources including chemical agents, ionizing radiation, ultraviolet light, 10. Evaluation of Immuno-inflammatory pathways of etc. DNA damage must be kept in check for an organism to function schizophrenia: Study of potential interactions between with homeostasis at cellular level; this is achieved through efficient HLA-G, NRG1 and cytokines. Ms. Ashwini R. Guides: DNA repair mechanisms. Epigenetic alterations lead to dysfunction Dr. Monojit Debnath, Dr. Venkatasubramanian Ganesan of DNA repair mechanisms leading to tumors. Hypermethylation of (Funding by DST INSPIRE) MGMT is a good prognostic and predictive biomarker, but there is no clear understanding of the clinical implication status especially Schizophrenia, a complex psychiatric disorder, is now being recognized with respect to Indian population. This being one of the reasons for to have a strong immunological basis. It has been hypothesized the limited use in routine clinical management of patient with high that aberrant expression of immune molecules during the early grade glioma, leading to poor survival. Exploration of the functional gestational period (due to prenatal environment) might contribute downstream pathways of MGMT is needed to better understand to neurodevelopmental abnormalities in the offspring, leading to the Epigenetic alterations. DNA mismatch repair (MMR) genes, schizophrenia like behavior in the adulthood. In the current study, downstream repair pathway of MGMT gene play an important role in polymorphisms of HLA-G, NRG-1 and cytokines genes, and relating DNA repair. It is evident that MMR genes would have some kind of them to their expression profiles in schizophrenia patients are being mutation along with silencing of MGMT gene, and this could be one
154 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 of the events leading to glioma-genesis. Based on this hypothesis, the that age identity is associated with severely disabling psychosocial study aims to explore the roles of DNA MMR genes in co-relation factors that need careful social care and policy interventions. with methylation status of MGMT gene and how this correlation plays a role in glioma progression. The possibility of this correlation could be used as significant biomarker. 2. Outcome of a school-based health education program for epilepsy awareness among teachers and school children. 13. Study on the regulation of human Telomerase in Investigators: Dr. KS Meena, Dr. Prakashi Rajaram, Dr. Glioblastoma cell lines using knockdown approaches. Ms. M Marimuthu, Dr. Vivek Gupta, Mr. Kannappa Setty Lavanya CH. Guides: Dr. Chetan GK, Dr. Srinivas Bharath (NIMHANS Intramural Funding) MM (Funding by UGC-Rajiv Gandhi National Fellowship, India) The project focuses on training government school children and teachers in Epilepsy Awareness. Before the pilot phase was taken Gliomas are the mostcommon primary malignant central nervous up, a Knowledge, Attitude and Practice [KAP] tool was developed system tumors that arise from glial cells. It accounts for 78 per cent of by the investigators. The tool was given to experts for validation all malignant brain tumors. More than 50 per cent of glioma tumors at NIMHANS. Two schools were identified for pilot study and have high telomerase activity and detection rates increases with the training was imparted to teachers and school children. As a mode of grade of malignancy. Many approaches have been tried for inhibition intervention, posters and a video in tandem with school children and of telomerase activity in malignant gliomas with some success. The teachers were developed to convey messages with regard to epilepsy present study is to inhibit the telomerase activity using siRNA and awareness, such as first aid for epileptic seizures and role of teachers monoclonal antibody approach in glioblastoma cells line. Telomerase and students. The IEC material developed were used for training activity will be measured by TRAP-ELISA kit, mRNA Expression by in the intervention phase. Post the pilot study, three schools were qRT-PCR, protein studies by western blotting. Flow cytometry assays identified, out of which one was identified as control group. The to study cell cycle analysis and apoptosis.The study will investigate KAP tool was administered and interventions were carried out by the whether siRNA and monoclonal antibodies could down regulate investigators for two schools. A post assessment follow-up would be the expression levels of telomerase activity and possibly helps in the carried out after six months for all three schools respectively. treatment of gliomas.
Neuroanaesthesia Mental Health Education 1. Feasibility of scalp block and dexmedetomidine bolus for 1. Factors influencing elderly persons’ negative age identity: An chronic subdural hematoma evacuation. Investigators: Dr. exploratory analysis. Investigators: Dr. Justin Jose, Dr. KS Sriganesh K, Dr. Madhusudan Reddy (Non-funded) Meena (Funding by ICSSR) Choice of anesthetic for burr hole evacuation of chronic subdural The investigators examined the factors influencing negative age hematoma is complicated because of advanced age, associated co- identity in a representative sample of 573 elderly persons aged 65 morbidity, neurological issues and short duration of procedure. As years and more from three districts of Kerala, South India. Age both local and general anesthetic technique have their limitations, role identity was measured in terms of ageing experience, age identity of sedo-analgesia needs to be explored. The current study aimed at importance, personalized self and social images of ageing, using Age evaluating feasibility of using dexmedetomidine bolus with scalp block Identity Measurement Scale. The independent variables measured for chronic subdural hematoma evacuation. A single dexmedetomidine were elderly persons’ self-image, self-esteem, personal autonomy, bolus in combination with scalp block provided adequate operating social integration, social relations, social support and loneliness, using conditions in patients undergoing chronic subdural hematoma standardized scales. The study examined the differences and variances evacuation without the need for conversion to general anesthesia. of the sub-dimensions of age identity on selected categorical variables. The known side effect of hemodynamic suppression did not adversely Multivariate regression analysis was used to examine the significant affect the cardiovascular or neurological outcome. predictor variables of (negative) age identity. The model reveals that stigma (β=.314) self-esteem (β=.-.337), personal autonomy (β=.124), 2. Upper airway morphology and hemodynamic changes during negative self-image (β=.140) and loneliness (β=.105) have together sedation with dexmedetomidine and propofol for neuro- accounted for 58.9 per cent of variance on elderly persons’ negative age diagnostic procedures. Investigators: Dr. Sriganesh K, Dr. identity (R2=.589) with an adjusted R2 of 0.586. The study concludes Jitender Saini
National Institute of Mental Health and Neuro Sciences 155| Annual Report 2014-15
Children with neurological disabilities are at increased risk of airway fluctuations in the perioperative period. The investigators would be problems during anesthesia for magnetic resonance imaging (MRI) correlating the abnormal findings of heart rate variability recorded study with spontaneous respiration. This study aimed at evaluating the prior to surgery with intraoperative hemodynamics and condition of airway contours in children with neurological pathology undergoing patients at discharge from the hospital. The collection of data is nearly MRI study with two different anesthetic regimens: propofol and complete. dexmedetomidine. Significant changes occur at the level of soft palate and base of tongue during sedation with propofol as compared 7. A survey of perioperative complications in patients to dexmedetomidine during MRI study in spontaneously breathing undergoing craniotomy under general Anaesthesia. children. The study, in the interim analysis demonstrated that airway Investigators: Dr. GS Umamaheswara Rao, Dr. VJ Ramesh dimensions were better maintained and airway and desaturation incidents were less common with dexmedetomidine during MRI This is a multi-institutional study. The principal objective of this study in children with neurological disability. study is to observe and evaluate any complications occurring in the perioperative period during the conduct of anaesthesia in the 3. ICP Sensor. Investigators: Dr. Anantha Suresh, IISC, Dr. neurosurgical patients over a period of time. The results obtained will GS Umamaheswara Rao (Funding by Society for Biomedical be critically analysed and factors which can give rise to complications Technology, Ministry of Defence, Govt. of India) will be identified and possible protocols which may minimise or prevent these complications will be evolved. The data collected from A sensor has been developed, which requires to be packaged to the three institutions i.e. NIMHANS, Bangalore, PGIMER, Chandigarh, human requirement which will be taken up in a subsequent project to AIIMS, New Delhi is yet to be analysed. be undertaken shortly. 8. Large observational study to understand the global 4. Intraoperative cardiac output monitoring and its impact on impact of severe acute respiratory failure- LUNG SAFE neurological outcome in patients undergoing emergency trial. Investigators: Dr. M Radhakrishnan, Dr. VJ Ramesh craniotomy for traumatic brain injury. Investigators: Dr. V Sudhir, Dr. Bhadrinarayan (NIMHANS Intramural It is an international, multi-centric study. The data is collected on the Funding) web based forms. All patients admitted to the ICU receiving invasive or noninvasive ventilation were screened and included in the study. 5. A multicenter, prospective, observational registry for The data has been collected in fifty patients. The data analysis and assessment of clinical outcomes in Indian adult (≥18-40 years, publication of the results are pending. ≥41-65 and >65 years) in-patients undergoing surgery ≥2 hours duration during Suprane ® Anaesthesia. Investigators: 9. Comparison between SACETT and SETT on the incidence Dr. VJ Ramesh, Dr. M Radhakrishnan (Funding by Baxter of VAP in Neuro ICU. Investigators: Dr. Sriganesh, Dr. India Ltd.) Ravikumar R, Dr. Veena Kumari HB
It is a multi-institutional study with the primary objective of 10. A comparative study of postoperative pain following general obtaining information on practice and usage patterns of Desflurane anaesthesia with isoflurane and sevoflurane in spine surgery. when administered in a real-world setting to adult inpatients in India. Mr. Vivek Rayadurg. Guides: Prof. Bhadrinarayan V, Dr. Secondary objectives are to evaluate the length of time for recovery Sudhir V from anesthesia and the quality of recovery from anesthesia with the usage of Desflurane. Postoperative pain is a form of acute pain, which begins with surgical trauma and is relieved with tissue healing. Analgesic requirement 6. Heart rate variability as a tool to assess autonomic nervous following spine surgery is not addressed very clearly. Volatile system in patients with neurosurgical disorders. Investigators: anesthetics used during general anaesthesia are said to have a biphasic Dr. M Radhakrishnan, Dr. VJ Ramesh (Funding by DST) effect on pain sensitivity in animal models. Trials studying the effect of different volatile agents on postoperative pain in patients undergoing The study is about assessing the function of autonomic nervous system, spine surgery are lacking. This study is being conducted to identify in terms of heart rate variability (HRV), in patients undergoing factors which may play a role leading to differences in post-operative surgeries for supra and infratentorial tumors, intracranial aneurysms, pain. cervical compressive myelopathy and head injuries. HRV is assessed by recording the ECG for five minutes and calculating the R-R intervals 11. Comparison of Midazolam and target control based propofol from it. This group of patients tends to have greater hemodynamic infusion in refractory status epilepticus. Mr. Dheeraj
156 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Masapu. Guides: Dr. GS Umamaheswara Rao, Dr. Sanjib Mittal. Guides: Dr. GS Umamaheswara Rao, Dr. DN Sinha, Dr. Gopala Krishna (Non-funded) Nandakumar
Refractory status epilepticus (RSE) is defined as SE that fails to respond Tumour metastasis is a complex process that includes cellular to first- and any two drugs in the second-line therapy and it is observed separation from the primary tumour, invasion of and migration in 9to 31 per cent of the patients with SE. Thiopentone has been through surrounding tissues, invasion of the intravascular space, used in refractory status epilepticus but is associated with need for cellular transport in the bloodstream, and subsequent extravasation prolonged ventilation, high incidence of hemodynamic complications and proliferation in the target tissue or organ. Anaesthetics are widely and infections. Propofol and midazolam infusions are most commonly used during brain surgery. Anaesthetics and anaesthesia techniques used in the management of RSE in many centers and have better have some impact on invasion and migration ability of tumor cells elimination profile than thiopentone. Evidence is lacking on which of that can possibly affect long-term outcome of patients who have the two drugs—midazolamor propofol—is better in terms of seizure undergone cancer surgery. This study was planned to investigate the control and clinical outcome of patients with RSE. Target controlled effect of inhalation and intravenous anaesthetics on cell proliferation infusion (TCI), which provides the plasma concentration (Cp) and and migration of glioblastoma cells. effect-site concentration (Ce) of the anaesthetic agent might provide insights into the appropriate dose requirement on a continuous basis 16. Cardiac output changes during therapeutic large volume for effective control of seizures in RSE. plasmapheresis with non-invasive cardiac output monitor (NICOM) in neurological patients. Dr. Shweta S Naik. 12. Evaluation of dexmedetomidine as an anaesthetic adjunct Guides: Dr. V Bhadrinarayan, Dr. Sundar Periyavan to propofol during bispectral index guided anaesthesia for cerebello-pontine angle surgeries. Mr. Dhritiman In the first study, the investigators found a significant decrease in Chakrabarti. Guides: Dr. KR Madhusudan Reddy, Dr. cardiac output, cardiac index and stroke volume with an increase Sriganesh K in stroke volume variation and total peripheral resistance at 30, 60 and 90 minutes. The use of monitors such as heart rate Cerebello-pontine angle (CPA) surgeries tend to carry the surgeon’s and noninvasive blood pressure do not precisely represent the knife uncomfortably close to the brainstem, putting various cranial continuously changing intravascular volume. Monitoring of nerves at risk for damage. Total Intravenous Anaesthesia technique dynamic hemodynamic parameters which are better indicators of with propofol is considered as the anesthetic technique of choice for the hemodynamic status is recommended. Thus, the routine use such surgeries. High dose propofol can result in undesirable effects of monitoring of dynamic indices such as cardiac output, stroke like delayed awakening and metabolic acidosis with increased lactate volume and stroke volume variation should be considered during levels. Dexmedetomidine has been used as an anaesthetic adjunct therapeutic large volume plasmapheresis to ensure additional to propofol and has been shown to reduce propofol requirements. safety to the patient during plasmapheresis. Therapeutic large The aim of this study is to compare the anaesthetic technique of volume plasmapheresis is a safe procedure despite the continuous dexmedetomidine as an adjunct to propofol with propofol alone changes in intravascular volume. during Bispectral Index guided anaesthesia for CPA surgeries using cranial nerve monitoring. 17. Heart rate variability as a predictor of infection and organ dysfunction in neurological patients. Dr. Shweta S Naik. 13. Cardiac output and other hemodynamic changes with prone Guides: Dr. V Bhadrinarayan, Dr. Sudheer position in cervical myelopathy patients undergoing surgery. Mr. Nitin M. Guides: Dr. Ramesh VJ, Dr. Radhakrishnan M In the study, the investigators found no conclusive evidence that the changes observed in heart rate variability characteristics could precisely Cardiac output is measured noninvasively in various positions during predict infection or organ dysfunction. The use of changes in heart spine surgeries and compared between prone and supine positions. rate variability alone may not help in early prediction of infection and organ dysfunction in these patients. Further studies involving larger 14. Heart rate variability at different propofol effect-site number of patients belonging to a more homogenous group should concentrations in patients with supratentorial tumours. Mr. be conducted. Mohit Mittal. Guides: Dr. GS Umamaheswara Rao, Dr. M Radhakrishnan 18. Effect of atropine premedication on the cardiovascular system and autonomic nervous system in electroconvulsive therapy. 15. Effect of anaesthetics on glioblastoma cell line migration, Mr. Tanmay Ashok Jadhav. Guides: Dr. KR Madhusudan proliferation and matrix metalloproteinase-2. Mr. Mohit Reddy, Dr. Sriganesh K, Dr. Jagadisha T
National Institute of Mental Health and Neuro Sciences 157| Annual Report 2014-15
Effect of atropine premedication on cardiovascular system and hypernatremia was 2.8 per cent. More than 60per cent patients were autonomic nervous system was studied in randosmised cross over males. The mortality among hypernatremic patients was high and study. Fifty one patients requiring modified ECT for their psychiatric increased with increase in the severity of hypernatremia. Head-injured illness were included in the study during a six-month period. All patients had higher mortality compared to others but the diagnosis psychiatric patients undergoing electroconvulsive therapy aged itself was not an independent predictor of mortality. Independent between 18-60 years whose next-of-kin consented for the study were predictors of mortality were maximum sodium value and GCS. As included. Results demonstrate that atropine increases the workload on the mortality and morbidity in hypernatremic patients is very high, heart and aggravates autonomic dysfunction following ECT. Atropine these patients require regular monitoring and aggressive controlled premedication in dose of 0.01 mg/kg IV prevented bradyarrhythmias correction of serum sodium. but significantly increased heart rate. Use of atropine does not affect cerebral oxygenation Neurochemistry 19. Comparison of awake endotracheal intubation using intubating laryngeal mask airway and fiberoptic 1. Establishment of high-throughput mass spectrometry-based bronchoscope in patients with unstable cervical spine. Mr. screening for lysosomal storage disorders using dried blood Tanmay Ashok Jadhav. Guides: Dr. KR Madhusudan Reddy, spots. Investigators: Dr. Rita Christopher, Dr. Nagaraja D Dr. Sriganesh K, Dr. B Indira Devi (Funding by DBT, New Delhi)
It was a prospective, randomised controlled study to compare upper The investigators established a high-throughput, robust, and reliable, cervical spine excursion during oral tracheal intubation using fiberoptic mass spectrometry-based method to screen for lysosomal storage intubating scope with that during intubation via the ILMATM disorders (LSDs) using dried blood spots collected on filter paper. (Fastrach). Thirty two patients with unstable cervical spine who were The diseases selected include Gaucher, Pompe, Fabry, Niemann- scheduled for elective stabilization surgery were randomly allotted Pick types A and B and Krabbe diseases. Age and gender-based into two groups; Group FOB and Group ILMA. Cervical spine reference intervals for the 5 lysosomal enzymes, α-glucosidase, excursion during intubation with ILMATM was more as compared α-galactosidase, β-glucocerebrosidase, acid sphingomyelinase, and to that during intubation with fiberoptic intubation at C1-2. There galactocerebrosidase, and the cut-offs were established in normal was no neurological deterioration in either group post intubation. newborns and in subjects of different age groups. The effect of Patients in both the group tolerated the procedure well. Incidence of temperature on blood sample drying and storage, on lysosomal enzyme sore throat was more in patients intubated with ILMATM activity, was determined. Using this method, 9105 asymptomatic newborns and 4703 patients with various symptoms like seizures, 20. Spectrum of serum sodium disturbances in patients with developmental delay, organomegaly, etc., were screened for the 5 non-sellar/ suprasellar supratentorial tumors. Dr. Sritham LSDs. The positive cases were confirmed by leukocyte enzyme assays. Swarup Jena (DM in Neuroanaesthesia). Guides: Dr. VJ Since enzyme replacement therapy is available for Gaucher, Pompe Ramesh, Dr. Rita Christopher, Dr. DI Bhat. and Fabry diseases, early diagnosis before the onset of irreversible pathologies could lead to better outcomes for the patients. Hence, In this single center observational study, the investigators analysed to assess the feasibility of introducing newborn screening for LSDs the incidence of sodium disturbances in patients with non-sellar/ in India, a cost-benefit analysis was done based on the prevalence of suprasellarsupratentorialtumour patients in both prospective and these disorders and the cost of analysis. This showed that the costs retrospective manner. The investigators found a high incidence of of newborn screening for LSDs were greater than the net benefits in hyponatremia in these patients. Although there existed no difference monetary terms. between normonatremic and hyponatremic patients with respect to demographic and other parameters, the length of hospital stay was 2. Vitamin D receptor gene variants and vascular risk: Study significantly longer in hyponatremic patients. in ischemic stroke. Investigators: Dr. Rita Christopher, Dr. Nagaraja D (Funding by ICMR, New Delhi) 21. Evaluation of incidence and outcome of hypernatremia in adult neurologic patients – a retrospective study. Dr. Sritham Vitamin D receptor (VDR) is a potential candidate for cardiovascular Swarup Jena. Guides: Dr. VJ Ramesh, Dr. Rita Christopher, disease. The present study aimed to evaluate the association between Dr. Dhaval Shukla Vitamin D, VDR gene variants and ischemic stroke in Indian population. Overall, 557 subjects were investigated that included Hypernatremia was seen in all types of neurological disorders; 313 ischemic stroke patients and 244 controls. Four single nucleotide however, most were head-injured patients. Overall, incidence of polymorphisms of the VDR gene, Fok I, Apa I, Taq I and BsmI,
158 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 were genotyped by using PCR-RFLP method and vitamin D The treatment of rheumatic heart disease with valve replacement surgery levels were estimated by ELISA. The genotype distribution of Bsm with mechanical prothetic valves requires lifelong oral anticoagulation, I polymorphism was found to deviate from the Hardy–Weinberg to prevent thromboembolic complications. However, chronic equilibrium in control subjects, and hence excluded from the study. anticoagulation post-surgery is challenging because patients exhibit Apa I and Taq I polymorphisms were not found to be associated large variability in their dose-anticoagulant effect response thrombotic with ischemic stroke. However, presence of ff genotype of Fok I was complication. The inter-individual variability is known to depend on found to confer 2.97-fold risk of stroke (95% CI = 1.16–7.63, P = environmental factors, but a genetic influence has also been demonstrated. 0.02) as compared to FF genotype. On stratification by gender the The two key enzymes in the metabolism of Acitrom are cytochrome P450 genetic association between Fok I polymorphism and ischemic stroke (CYP) 2C9 (CYP2C9 gene) and the C1 subunit of the vitamin K 2, 3 remained significant in females only (OR=2.28, 95% CI=1.15–4.53, epoxide reductase complex (VKORC1 gene). The aims and objectives P=0.02). Conversely, severely deficient levels of vitamin D were of this study are to explore the contribution of CYP2C9 and VKORC1 associated with 3.13-fold increased risk of ischemic stroke, and with gene polymorphisms on optimal therapeutic dose requirements of oral hypertension the risk was 13.54-fold. Further larger scale validations anticoagulants in patients with cardiac valve replacement. in other population are warranted. 6. Influence ofCYP 2C9 and VKORC1 gene polymorphismsin 3. Vitamin D status and vascular cognitive impairment in the patients on oral anticoagulant therapy presenting with elderly. Investigators: Dr. Rita Christopher, Dr. Chandra SR prosthetic valve thrombosis. Investigators: Dr. Kalpana (Funding by ICMR, New Delhi) SR, Dr. Nagaraja Moorthy, Dr. CN Manjunath, Dr. Rita Christopher (Funding by RGUHS Research Grant, The objectives of this study are to determine whether Vitamin D Bangalore) insufficiency is associated with increased risk for severe vascular cognitive impairment (VCI) in the elderly, to establish whether the The aim of this study is to explore the contribution of CYP2C9 and gene variants of the Vitamin D metabolic pathway could predict the VKORC1 gene polymorphisms in patients on oral anticoagulant risk for cognitive decline and to elucidate the possible mechanism by therapy presenting with prosthetic valve thrombosis. which low vitamin D status could increase risk for vascular cognitive impairment. A total of 100 cases with VCI and 100 healthy age and 7. Genetic determinants of platelet response during low dose gender-matched controls have been investigated. The present data aspirin therapy. Investigators: Dr. Rita Christopher, Dr. SR shows that Vitamin D receptor (VDR) gene variants are not associated Chandra (Funding by ICMR) with increased risk for VCI. There is no significant difference in mean serum vitamin D in patients compared to healthy controls; this may 8. Protective role of Withania somnifera against scopolamine- be due to the small sample size. However, IL-1α and TNF- α levels induced memory impairment in Alzheimeric rats. were elevated in VCI patient group as compared to controls. Further Investigators: Dr. G Visweswari, Dr. Rita Christopher recruitment of patients and controls is being carried out to obtain (Funding by DST-SERB Fast Track) a larger sample size. Complete data analysis will be done after the recruitment and investigation of all patients. The objective of this project is to study the effect of different fractions isolated from the medicinal plant, Withaniasomnifera, on 4. Identification of circulating microRNA signature for the the pathophysiological neurotransmitter mechanisms in scopalamine- diagnosis of cerebral small vessel disease. Investigators: induced dementia. The investigators found that methanol, n-hexane Dr. Rita Christopher, Dr. Chandra SR (Funding by Vision and aqueous extracts of Withania showed significant protection Group on Science and Technology) against scopolamine-induced acetylcholine deficiency by inhibiting acetylcholine esterase and activating choline acetytransferase. These The aim of this research is to study the plasma microRNA expression extracts also showed neuroprotection by decreasing the glutamate pattern in patients with cerebral small vessel disease (SVD) and age excitotoxicity by activating the glutamate dehydrogenase and glutamine and gender-matched healthy controls and to identify and validate synthetase. Recovery in norepinephrine and dopamine levels after a miRNA signature which can be used as a diagnostic aid for early treatment with the extracts was observed. Histopathological studies detection of cerebral SVD. showed neuronal death in scopolamine-induced tissues and recovery of neuronal loss with these extracts of Withania. 5. Pharmacogenetics of oral anticoagulation therapy in patients with cardiac valve replacement. Investigators: Dr. Kalpana 9. A study of neuroprotective aspects of Klothobiology. SR, Dr. Rita Christopher, Dr. Manjunath (Funding by Investigators: Dr. Vijaya Majumdar, Dr. Rita Christopher ICMR, New Delhi) (Funding by DBT, New Delhi)
National Institute of Mental Health and Neuro Sciences 159| Annual Report 2014-15
Various neuroprotective and neurorestorative mechanisms are i.e. amyloid ß (Aß) and acetylcholinesterase (AChE) levels showed deployed by brain cells to maintain their integrity, facilitate responses marked elevation in these two parameters in the hippocampus of to environmental demands and promote functional recovery after MSG-treated rats. Assessment of cognitive abilities by Barnes maze cellular insults. Klotho, a novel anti-aging protein has been shown revealed spatial disorientation characteristic of AD. Administration of to have a plethora of biological functions viz., regulation of mineral ghrelin receptor analog [D-Lys (3)] GHRP-6 to obese rats resulted in metabolism, vascular homeostasis, regulation of metabolic pathways significant restoration of serum cholesterol, glucose, leptin and ghrelin and protection against oxidative stress. Unraveling of Klotho biology levels to that of control with concomitant reduction in hippocampal has been of great impact on aging research. Owing to its abundant Aß and AChE levels and marked improvement in Barne’s maze task. expression in brain and its reported ability to mediate apoptosis and These findings suggest that MSG-induced obese rats may serve as combat oxidative stress, it was hypothesized that Klotho could play a non-transgenic animal model for AD research. Further, the results role of neuroprotectant. The proposed project will attempt to elucidate indicate the potential of [D-Lys (3)] GHRP-6 as a promising anti- the neuroprotective aspect of Klotho’s biology. It will involve the Alzheimer candidate. analysis of the effects of overexpression of Klotho on neuronal death caused by exposure to various cellular insults like oxidative stress, excitotoxicity and trophic deprivation. Experimentally stable PC12 cells transfected with Klotho encoding plasmid have been generated and the control as well as Klotho overexpressing cells treated with a variety of cellular insults, followed by assessment of cell survival and apoptotic cell death. Further studies are being carried out.
10. Elucidation of the role of estrogen in the etio-pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH). Investigators: Ms. Shruthi Ramesh, Dr. B. Indira Devi, Dr. Rita Christopher, Dr. Dhananjay I Bhat (Funding by ICMR, New Delhi) Fig: 1(A) Performance of rats in 8 arm baited task: Significant improvement in acquisition is seen from day 3 in controls (CM) whereas MSG treated rats (TM) The objectives of this study are to determine whether genetic variants showed considerable delay in learning. Values represent mean ± SEM (n = 8) of the estrogen receptor genes are associated with increased risk by two way ANOVA followed by post hoc Bonferroni test for group differences. for aneurysmal subarachnoid hemorrhage (SAH), and to elucidate #P < 0.05, ##P < 0.001 and ###P< 0.0001 for Control males (CM). *P < 0.05, **P < 0.001 and ***P < 0.0001for MSG treated rats (TM). (B) Retention of whether circulating estrogen level is associated with gender gap in the 8 arm baited task: Control rats (CM) have shown almost 100% retention aneurysmal subarachnoid hemorrhage. The investigators found a of the acquired task whereas MSG rats (TM) showed significant reduction. The retention was compared with the performance obtained on the 20th trial. significant difference in the distribution of the TT genotype in ER Each value represents mean ± SEM (n = 8) by two way ANOVA followed by alpha polymorphism (Pvu II) between cases and controls. However, post hoc Bonferroni test for group differences. *P < 0.05, **P < 0.001 and no significant difference is found in genotype distribution of ER beta ***P < 0.0001 compared to controls (CM). C&D Working memory and Reference memory errors committed by rats polymorphism between cases and controls. Further collection and during retention of the 4-arm radial maze task. Each value represents the analysis of samples are being carried out. mean ± SEM, (n = 8) per group. The MSG treated (TM) group made more working memory (A) and reference memory (B) errors during the retention trials when compared with the control group (CM) indicating poor memory 11. Role of ghrelin-leptin (im) balance on Alzheimer’s disease. consolidation. *P < 0.05, **P < 0.001 and ***P < 0.0001 compared to controls Investigators: Mrs. Sowmya Madhavadas, Dr. Sarada (CM). Subramanian, Dr. Bindu M Kutty (Funding by DST, New Delhi)
Obesity, arising due to the dietary and life style changes, is fast reaching epidemic proportions all over the world. The incidence of Alzheimer disease (AD) is significantly influenced by a cluster of metabolic diseases including diabetes and obesity. The aim of the present study is to test the suitability of experimentally induced obesity Histology: Coronal hippocampal tissue sections of the dentate gyrus (DG) showed marked reduction in the volume revealed by cresyl violet in rats as an experimental animal model of AD. Results revealed that counterstaining in the MSG-treated rat compared to the age matched control administration of monosodium glutamate (MSG) to neonatal rats at 2 months of age. C&D cresyl violet stained sections of dentate gyrus exhibited increased body mass index and serum glucose levels over showing the effect of MSG induced changes in the control (CM, 3(A) and MSG treated group (TM, 3(B) at 4X magnification. 3C of CM at 40X magnification. the controls. Measurement of markers for AD-like molecular changes 3D, of TM at 40X magnification.
160 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
12. Tau-focused immunotherapeutic approaches to Alzheimer’s that show neuroprotective property in the cell model would be tested disease. Investigator: Dr. Sarada Subramanian (Funding by in an MPTP mouse model of Parkinson’s disease. The analysis in the CSIR, New Delhi) models includes monitoring of motor behavior, apoptotic markers, dopaminergic markers, redox and mitochondrial markers. Alzheimer’s disease (AD) is the leading cause of dementia, affecting more than 30 million worldwide. The two major pathological 15. Generation of experimental models of muscular dystrophy: findings in patients with AD are extracellular plaques formed mainly analysis of molecular mechanisms and myoprotection. of amyloid ß (Aß) peptide and intracellular neurofibrillary tangles Investigators: Dr. Srinivas Bharath MM, Dr. N Gayathri (NFT) which contain hyperphosphorylated tau. The cognitive (Funding by ICMR, New Delhi) impairment in patients with AD is closely associated with loss of synapses and the formation of NFT in the neocortex and limbic The current project deals with the characterization of an acute model system. Potential side effect of current tau-based immunotherapy of muscle injury and degeneration and comparison of its salient targeted primarily towards the central proline rich region and the pathological features with human muscular dystrophies (MDs) and positively charged C-terminal region is that it is prohibiting normal inflammatory myopathies (IMs). The researchers investigated the tau from performing its normal cellular functions. Given that there are cardiotoxin (CTX)-mediated transient acute mouse model of muscle multiple phosphorylations on tau, many of them have been reported degeneration and compared the cardinal features with the human to have pathological consequences; the identification and selection MDs and IMs. The CTX model displayed lowered muscle strength, of the most therapeutically relevant phospho-epitopes requires muscle degeneration, apoptosis, inflammation, loss of sarcolemmal further research. In the first phase, the neutralizing potential of the complexes, sarcolemmal disruption and ultrastructural changes immunodominant epitopes located in the N-terminal region of Tau characteristic of human MDs and IMs. Cell death caused by CTX (residues 18-50, 68-71 and 111-137) are being tested in rat models. involved calcium influx and mitochondrial damage both in a murine C2C12 muscle cell line and in mice. The myodegeneration observed 13. Nano assisted C60-pyrimidine derivatives: Their synthesis, in the mouse model was followed by a regenerative process which was characterization, neuroprotective and antiviral activities. completed by 31 days following CTX administration treatment of the Investigators: Dr. Srinivas Bharath MM, Dr. Devashish CTX cell and animal model with the dietary polyphenol curcumin Sengupta, Assam University, Dr. Shaheed Jameel, ICGEB, caused significant hastening of the regeneration and recovery New Delhi (Funding by DBT, New Delhi) of muscle strength. Curcumin treatment increased the cellular antioxidant potential by increasing the total glutathione content The current project deals with the analysis of the neuroprotective thereby decreasing the oxidative stress. Curcumin has myoprotective effects of novel nanocompounds in experimental models of Parkinson’s properties with implications for myodegeneration. disease. Till date, 6 pyrimidine-based compounds (nano compound precursors) have been tested in N27 dopaminergic neuronal cell line 16. Analysis of the epigenetic regulation of red/ox mechanisms in for their pharmacological dose. All the compounds were non-toxic neurotoxic models of Parkinson’s disease: Role of chromatin up to 250µM in vitro. However, none of the compounds offered modifications. Investigators: Dr. Mythri R, Dr. Srinivas neuroprotection against rotenone-mediated neurotoxicity, based on Bharath MM (Funding by DST, New Delhi) cell viability data. The project involves genetic and epigenetic analysis underlying 14. Analysis of neuroprotective properties of natural compounds Parkinson’s disease (PD) using cell and animal models with specific and their derivatives/pro-drugs in experimental models of focus on histone acetylation/deacetylation dynamics. Towards this Parkinson’s disease with potential therapeutic implications. objective, the cell and animal models of PD were characterized. The Investigators: Dr. Srinivas Bharath MM, Dr. Muralidhar PD toxin 1-methyl-4-phenylpyridinium (MPP+) induced loss of and Dr. PS Rajini from CFTRI, Mysore, Dr. Krishna Misra, cell viability in N27 dopaminergic neuronal cells in a time and dose CBMR, Lucknow (Funding by DBT, New Delhi) dependent manner. MPP+ increased oxidative stress and mitochondrial dysfunction as indicated by an increase in pro-oxidant markers The current project deals with the analysis of the neuroprotective and loss of mitochondrial membrane potential. Morphological and effects of novel curcumin bioconjugates in experimental models of ultrastructural analysis of MPP+ treated cells indicated the presence Parkinson’s disease. The initial part of the project involves design, of apoptotic features. Microarray based analysis in N27 cells indicated synthesis, isolation, purification and characterization of the curcumin 848 genes up-regulated and 516 genes down-regulated by MPP+ derivatives. These molecules will be tested for potential neuroprotective respectively. Upregulation of chosen genes from microarray analysis and therapeutic properties in vitro in N27 dopaminergic neuronal was corroborated by western blot and activity assays. Behavioural model and drosophila models of Parkinson’s disease. The molecules analysis in mice injected with the PD toxin 1-methyl-4-phenyl-
National Institute of Mental Health and Neuro Sciences 161| Annual Report 2014-15
1,2,3,6-tetrahydropyridine (MPTP) indicated significant behavioural Jakob disease. Investigators: Dr. Sarada Subramanian, Dr. deficits. MPTP injection caused significant locomotor deficits (as P Satishchandra, Dr. SK Shankar, Dr. Anita Mahadevan indicated in pole test). (Funding by ICMR)
17. Role of glutamate excitotoxicity and cytokines in invasion The 14-3-3 protein belongs to a family of conserved, dimeric of glioblastoma. Investigators: Dr. Nandakumar DN, Dr. proteins expressed as 7 isoforms in various mammalian tissues and Sampath S, Dr. Vani Santosh (Funding by DBT, New Delhi) involved in multiple cellular processes. The objective of the proposed study is to evaluate the diagnostic potential of 14-3-3 proteins in Glioblastoma (GBM) is one of the most common malignant tumours CSF as biomarker of neuronal injury especially in suspected cases of the central nervous system. Despite new diagnostic techniques of Creutzfeldt-Jakob disease (CJD). Towards this, the amino acid and combined modality therapy prognosis remains dismal. Decades sequence of all the seven isoforms of 14-3-3 protein was subjected of surgical therapy, radiotherapy and chemotherapy have failed to multiple sequence alignment by ClustalW program. The analysis to drastically change survival. The addition of temozolomide to revealed the presence of five highly conserved blocks among the radiotherapy median overall survival has improved from 12.1 months isoforms. Arrangement of these common stretches in tandem to 14.6 months. They have exceptional ability to infiltrate normal separated by glycylglycine linker resulted in the core 14-3-3 protein brain, often along blood vessels or nerve fibres. This feature makes sequence. Minigene expressing this core protein was synthesized complete radical surgical resection virtually impossible and leading by overlapping PCR and the recombinant protein was produced by in almost all cases to tumor recurrence. Their genetic and metabolic employing bacterial expression system. Polyclonal antibodies were characteristics affecting invasive ability, alteration of immune response raised against the purified recombinant protein and used for dot and the development of treatment resistance must be understood in blot assay development with avidin-biotin technology for signal detail to address them in a meaningful fashion. amplification. This method was used for quantitation of 14-3-3 protein in CSF Samples. Screening of CSF samples from CJD cases One of the distinguishing features of the glioma tumors is their (n=40) and controls (n=40) revealed approximately ten-fold difference diffuse infiltrative nature. Several factors are thought to contribute to in the amounts of 14-3-3 protein between the groups suggesting the the invasive and migratory properties of GBM cells, interacting with diagnostic potential. Development of isoform specific immunoassays the microenvironment and enhancing motility and invasion. is in progress.
The investigators aim at understanding glutamate excitotoxicity in GBM and the role of cytokines on invasiveness of tumour and by doing so, perhaps contribute to the understanding of the complex biological interactions that regulate glioblastoma migration, invasion and recurrence.
18. Genetic and biochemical profiling of patients with glutaric aciduria type I. Investigators: Dr. Kruthika Vinod TP (Funding by DST, New Delhi)
Glutaricacidemia type 1 is an autosomal recessive disorder of amino acid metabolism and caused due to deficiency of the enzyme glutaryl-CoA dehydrogenase, a mitochondrial enzyme located in (a) Analysis of PCR products by 2% agarose gel electrophoresis; (b) Tricine SDS-PAGE analysis of purified recombinant core 14-3-3 protein; (c) Dot-blot the degradative pathway of the amino acids lysine, hydroxylysine detection sensitivity of biotinylated anti-core 14-3-3 antibody and tryptophan. The aim of this study is to correlation between the biochemical phenotype with its respective genotype and to know the prevalence of low excretes and its genotype in Indian population. 20. Circulating microRNAs: Role as molecular biomarkers in The findings from this study will help in improvising the diagnostic cerebral small vessel disease. Mr. Prabhakar P. Guides:Dr. sensitivity and specificity of neonatal screening for GA-I and in Rita Christopher, Dr. SR Chandra. acquiring accurate figures on its prevalence in the population. Cerebral small vessel disease (SVD) is a common cause of vascular 19. Development of ELISA and evaluation of the dementia and age-related cognitive decline. The objectives of this potential of 14-3-3 as a biomarker of neuronal injury/ study were to identify the differentially expressed miRNAs in the neurodegeneration with special reference to Creutzfeldt- plasma of SVD patients by qPCR profiling and determine their utility
162 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 as molecular biomarkers to diagnose SVD. Three miRNAs 409-3p, level of IL-6 gene expression increases with the grade of malignancy. 376-3p and 502-3p were found to be significantly dysregulated. The investigators aim to look at the effect of the interleukins IL-1β Validation study showed the sensitivity and specificity for these and IL-6 on glioma cells, as well as their interplay with glutamate miRNAs as biomarkers was 91%, 82% and 72% and 87%, 90% and receptors to mediate their action. 80% respectively. These miRNAs are known to target major pathways involved in neuro vascular pathology. 24. Role of glutamate excitotoxicity, TNF-alpha and IL-13 in the invasion of high grade glioma. Mr. Palaniswamy R. Guides: 21. Expression profiling of microRNAs and elucidation of their Dr. Nandakumar DN, Dr. Dwarakanath possible role in the formation and rupture of intracranial aneurysms. Ms. Supriya M. Guides: Dr. Rita Christopher, High grade gliomas are lethal as it infiltrates surrounding brain Dr. Dhananjaya I Bhat, Dr. B Indira Devi (Funding by part tissue. Glutamate uptake is reduced and excitotoxic concentrations of of a larger project funded by ICMR). glutamate are released leads to glioma growth. Eighty percent of the high-grade gliomas are positive for TNF-α and the decoy receptor for The objectives this study are to elucidate the plasma microRNA IL-13, IL-13Rα2 protein is expressed at high levels only in high-grade expression profiles in patients with intracranial aneurysms compared glioma cells. No study is available on the role of invasion mediated by to healthy controls, validate the differentially expressed plasma glutamate excitotoxicity, TNF-α and IL-13. The investigators plan to microRNA in a larger cohort of patients, determine the differentially study direct role of these on invasion and cross talk between these expressed miRNAs in the ruptured aneurysm tissue, identify the molecules and its signaling pathway. target genes for the differentially expressed miRNAs and elucidate the pathways associated with the formation and rupture of intracranial 25. Evaluation of the mechanisms associated with neurotoxicity aneurysm. in cell and animal models and neuroprotection by natural products: Implications for Parkinson’s disease. Mr. 22. Recombinant expression and characterization of core Raghunath N. Guide: Dr. MM Srinivas Bharath (Funding sequence of the various isotypes of human 14-3-3 protein and by CSIR-SRF) development of isoform specific immunoassays. Ms. Udaya Kumari HB. Guide: Dr. Sarada Subramanian Parkinson’s disease (PD) is a neurodegenerative disease that occurs due to the gradual degeneration of dopaminergic neurons leading to In this study, bulk amounts of ‘core’ 14-3-3 protein was obtained the loss of striatal dopamine. Environmental factors including metals by using bacterial expression system. The recombinant antigen was such as Manganese (Mn) contribute to neurodegeneration in PD. administered to rabbits to elicit immune response. It was observed Acute exposure to Mn in vitro in dopaminergic neuronal cells caused in ELISA that the immune serum recognized the antigen in a dose- neurotoxicity and elevated oxidative damage in a dose dependent dependent manner and the dilution of antiserum required to reach manner. Mn also induced ultrastructural changes in N27 cells and 50% binding of maximum was found to be 1:10000. Further, dot lowered the mitochondrial membrane potential. Transcriptomic blot analysis was carried out with serially diluted antigen and by analysis based on cDNA microarray approach demonstrated significant introducing avidin-biotin interaction in the intermediate steps, the alterations in gene expression in N27 cells. Mn administration induced sensitivity of the assay could be enhanced and it was found that, with mortality in drosophila model and caused motor dysfunction in mice. this method, lower limit of antigen detection was found to be 25 ng. Efforts are under way to enhance the sensitivity of detection to 26. Glutathione depletion induced behavioural and epigenetic picogram levels. changes in an animal model of oxidative stress: Implications for psychiatric disorders. Ms. Vidya K. Guides: Dr. MM 23. Role of IL1beta, IL6 and glutamate receptors in invasion Srinivas Bharath, Dr. BS Shankaranarayana Rao (Funding of glioblastoma. Ms. Hurmath Fathima K. Guides: Dr. by CSIR-SRF) Nandakumar DN, Dr. Sampath S (Funding by CSIR-JRF/ part of a funded large project (DBT)) Certain common symptoms of psychiatric disorders include impaired cognition, altered capacity in learning and memory, decreased social Glioblastoma multiforme (GBM) is one of the most common primary interactions and display of anxiety. At the tissue level, they share brain tumors with poor prognosis and highly invasive behavior. common pathways including altered neurotransmitter systems, Glutamate has been implicated as an important player in the growth neuroinflammation, oxidative damage, mitochondrial dysfunction and invasion of gliomas. IL-1β has been implicated in glioblastoma and dysregulation of genetic and epigenetic mechanisms. Among invasiveness. Evidence has emerged on the interplay between IL-1β these, oxidative damage and epigenetic mechanisms require further and excitotoxicity in case of ischemic brain damage. In gliomas, the analysis. This project aims to understand the effect of glutathione
National Institute of Mental Health and Neuro Sciences 163| Annual Report 2014-15
(GSH) depletion mediated oxidative stress on learning, memory and and postmortem (PM) samples. Morphologically, PM samples with cognition in young and old rats. Further, the dynamics of chromatin high glucose showed diabetic changes compare to AM. Increased acetylation in this oxidative stress model would be tested. complex I and II and decreased complex IV activities was observed in diabetic samples compare to control. Increased postmortem interval 27. Comparative analysis of cellular changes in Duchenne (> 24h) affected the complex activities compared to control. muscular dystrophy (DMD), sarcoglycanopathies and other muscle diseases: Focus on mitochondrial function. 30. Immunotherapeutic potential of N-terminal fragments Ms. Debashree Bandopadhyay. Guides: Dr. MM Srinivas of Tau (NTF-Tau) in tauopathy model rats. Mr. Ganesh Bharath, Dr. N Gayathri, Dr. A Nalini (Funding by ICMR- Savanur. Guide: Dr. Sarada Subramanian SRF) Presence of neurofibrillary tangles containing hyperphosphorylated Muscular dystrophies (MDs) arise due to muscle protein defects. tau is characteristic of the Alzheimer’s disease neuropathology. As Molecular mechanisms underlying MDs include necrosis/apoptosis, cognitive functions correlate well with the degree of tau pathology, inflammation, calcium dysregulation etc. The role of mitochondrial clearing these aggregates is a promising therapeutic approach. The dysfunction and oxidative stress in muscle damage and degeneration is aim of the proposed study is to evaluate the influence of active being recognized. Analysis of a mouse model of muscle degeneration immunization with pathology specific phospho-tau epitopes from our lab clearly demonstrated the role of oxidative stress and on prevention of tauopathy in healthy animals and passive mitochondrial damage in muscle pathology. However, the status of immunoneutralization studies on restoration of neuronal function in these processes is not thoroughly investigated in human muscle. The the animal models of tauopathy. current project aims to characterize human MDs and related muscle pathologies with a focus on mitochondrial function using biochemical, histological and proteomic methods. Neuro Imaging and Interverntional Radiology 28. Epigenetic analysis in the 3-nitropropionic acid (3-NPA) model of neurotoxicity: Implications for neurodegenerative 31. Generativity in cognitive networks: Mild Traumatic Brain diseases. (Tentative title) Ms. Ranganayaki S. Guides: Dr. Injury. Investigators: Dr. B Indira Devi, Dr. Rose Dawn MM Srinivas Bharath, Dr. B Padmanabhan (Funding by Bharath (Funding by DST) UGC-JRF) Spatiotemporal dynamics of resting brain connectivity ensuing mild 3-Nitropropionic acid (3-NPA) is a fungal toxin and a food toxin that traumatic injury causes neurotoxicity in the striatum via inhibition of mitochondrial Brain reveals amplified plasticity as it recovers from an injury and complex II leading to mitochondrial damage. 3-NPA is known to the principles of plasticity is conserved across different phyla. The causes dose dependent neurotoxicity in dopaminergic cells in vitro, investigators aimed at visualizing the spatiotemporal dynamics of along with increased oxidative stress, lowered antioxidant function whole brain plasticity by using resting connectivity in individuals (depletion of glutathione, etc.) and mitochondrial damage. The recovering from mTBI. Twenty six uncomplicated mild head injury current project aims to characterize the epigenetic mechanisms patients were longitudinally evaluated within 36 hours, at 3 and 6 induced by 3-NPA in cell model by analyzing the (i) status of the months using resting state functional connectivity (RSFC). Group post-translational modifications of histones such as acetylation (ii) seed to voxel connectivity differences over time and sliding healthy activities of histone acetyl transferases and histone deacetylases both control comparison was assessed with a threshold of FDR <0.05 in vitro and in vivo. Several areas in the right hemisphere revealed significant connectivity 29. Morphological and biochemical analysis of peripheral nerve: differences within 36 hours. Majority of these connections were Focus on mitochondrial function. Ms. Safoora Naaz. Guides: interhemispheric. By three months these areas significantly reduced Dr. MM Srinivas Bharath, Dr. TC Yasha, Dr. N Gayathri and were prominently intrahemispheric. At six months only significant connectivity differences were seen involving the right inferior parietal Peripheral neuropathies cause significant morbidity in the human lobule, right cuneus and right inferior temporal gyrus. Bilateral middle population. Studies have indicated the role of mitochondrial frontal gyrus, right inferior parietal lobule and inferior temporal gyrus dysfunction in the pathology of neuropathies. Although data had time varying connectivity differences. on mitochondrial status exist in experimental models, studies in human peripheral nerve are limited. This study investigated the Resting state fMRI can visualize the time and area dependent mitochondrial status in human sural nerves from ante-mortem (AM) schedules of brain plasticity as the brain recovers from mTBI. Several
164 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 areas in the non-dominant hemisphere transiently supports recovery of meditation does induce neuronal and hemodynamic functional and areas like bilateral middle frontal gyrus, right inferior parietal changes in the brain and DMN correlated EEG Microstate is a viable lobule and right inferior temporal gyrus are dynamic and multifaceted tool in quantifying these changes. as they assume variable connectivity over time.
Statisticalgraphical representation for Mean, standard deviation, maximum variance of DMN Microstate (a) duration and (b) occurance/sec in healthy control, meditator and meditator during meditation state.
32. Generativity in cognitive networks: Meditation. Investigator: Dr. Rose Dawn Bharath (Funding by DST)
Mapping of Default Mode Network with EEG-Microstate in Long- Term Raj Yoga Meditators The study aims to examine the dynamic changes in functional brain networks in trained meditators, when they are at rest and during meditation using simultaneous EEG fMRI.
Dual regression analysis of between-group effects for the DMN components The investigators prospectively evaluated 20 long-term Raj Yoga showed significantly (P<0.05 FDR corected) increase in meditator (a) and Meditators (>10 years of practice) and compared them with 20 further more increase during meditation (b) state in the right medil frontal healthy controls, using simultaneous EEG-fMRI. Resting state gyrus (MNI coordinate x: 42, y: 8, z: 46) and left middle temporal gyrus (MNI coordinate x: -60, y: -12, z: -26). The images are represented in MNI 152 space. functional magnetic resonance imaging (rs-fMRI) derived Default Mode Network (DMN) was integrated with electroencephalography 33. rTMS induced modulations of resting state functional (EEG) derived EEG-Microstates and this DMN correlated EEG connectivity in writer’s cramp. Investigators: Dr. Bhaskar microstate (DMN microstate) was quantified for its occurrence and MV, Dr. Rose Dawn Bharath duration. Dual regression analysis of DMN microstate and DMN was performed between meditators and healthy controls and also Repetitive transcranial magnetic stimulation induced modulations of between rest state and meditation state in meditators to ascertain resting state motor connectivity in writer’s cramp changes induced by the practice of long term meditation and during This study aimed to visualize the motor network abnormalities in WC meditation respectively. and also its rTMS induced modulations using resting state functional magnetic resonance imaging (rsfMRI). The investigators noted that the average duration of DMN microstate was significantly high (P value: 0.03) in meditators (118.1ms) Nineteen patients with right-sided WC and 20 matched healthy compared to healthy controls (94.35ms) at rest. During meditation controls (HCs) were prospectively evaluated. All patients underwent the duration further significantly increased to 132.25ms. DMN a single session of rTMS and rsfMRI was acquired before (R1) and in long term meditators revealed decreased activation in posterior after (R2) rTMS. Seed-based functional connectivity analysis of cingulate cortex (PCC) and medial prefrontal cortex (MPFC) as several regions in the motor network was performed for HCs, R1 compared to healthy controls at rest. During meditation, these areas and R2 using SPM8 software. Thresholded (P < 0.05, false discovery showed further reduced activation while right middle frontal gyrus rate corrected) group level mean correlation maps were used to derive (R-MFG) and left posterior middle temporal gyrus (L-PMTG) significantly connected region of interest pairs. showed an increase in activation. Writer’s cramp showed a significant reduction in resting state functional The converging multimodal finding of increased duration of DMN connectivity in comparison with HCs involving the left cerebellum, microstate and decreased PCC-MPFC, increased R-MFG and thalamus, globuspallidus, putamen, bilateral supplementary motor R-PMFG region activity in DMN network suggests that the practice area, right medial prefrontal lobe and right post central gyrus. After
National Institute of Mental Health and Neuro Sciences 165| Annual Report 2014-15 rTMS there was a significant increase in the contralateral resting between controls and patients over a wide range of network sparsity state functional connectivity through the left thalamus-right globus (10 to 40%). Along with the whole brain differences in SW measures pallidus-right thalamus- right prefrontal lobe network loop. (P<0.05), certain regions showed significant differences (P<0.005) between the two groups. It is concluded that WC is a network disorder with widespread dysfunction much larger than clinically evident and changes induced It was noted that the clustering coefficient and path length were by rTMS probably act through subcortical and trans-hemispheric decreased on a whole brain level and localized regional level as well. unaffected connections. Longitudinal studies with therapeutic rTMS F+ had lesser SWC when compared to F- and FDR had disrupted will be required to ascertain whether such information could be used SWC when compared to >FDR group (P<0.005). Similarly siblings to select patients prior to rTMS therapy. had more disruption compared to other FDR group.
The present study reveals that patients with genetic risk have disruption of the small world properties in brain which is also proportional to the pattern of inheritance. Such evidence in more popular groups of epilepsy will help in triaging patients towards aggressive epilepsy treatment there by delaying the cognitive deficits.
Illustrative representation of the network topology of the motor network. The lines represent the connections between the source seed region and the target seed region. These results demonstrate the baseline connectivity of various subcomponents of motor cortex in patients with writer’s cramp (a) prior to repetitive transcranial magnetic stimulation (P < 0.05, family-wise error corrected). Reduced connectivity of all the seeds can be observed in comparison with the healthy controls (c). (b) Connectivity after a single session of repetitive transcranial magnetic stimulation which demonstrates diffuse increased connections with aggregation involving the cerebellum and basal ganglia.
34. Imaging correlates in hot water epilepsy. Investigators: Dr, Raghavendra, Dr. Rose Dawn Bharath, Dr. Sanjib Sinha, Dr. P Satishchandra 35. DTI evaluation of head bath triggering migraine. Investigators: Dr. Maya Dattatraya Bhat, Dr. Girish Baburao Complex network analysis of resting fMRI quantifies genetic risk of Kulkarni, Dr. Chandrajit Prasad, Dr. Bhavani Shankaar epilepsy Bagepally (NIMHANS Intramural Funding) The researchers investigated functional whole brain networks through Graph Theory Measures in patients diagnosed with hot water 36. Magnetic resonance imaging and neuropsychological epilepsy (HWE) who showed both familial (F+) and sporadic (F-) abnormalities in survivors of herpes simplex encephalitis. Dr. patterns. They explored abnormalities in the measures of correlation Gorky Medhi. Guides: Dr. AK Gupta, Dr. Jitender Saini, Dr. coefficients, path length and small world-ness, as measures of Keshav Kumar, Dr. Netravathi M disrupted functional connectivity. The objectives of the study are (i) to explore white matter tissue Fifty five HWE probands and 30 healthy controls were scanned in integrity in patients who had suffered from with herpes simplex this study. First the data was preprocessed using SPM (realigned, encephalitis (ii) to detect cognitive deficit through neuropsychological co-registered and normalized to MNI space. Subsequently the brain evaluation (iii) to correlate diffusion tensor imaging findings with was parcellated into 200 ROIs (Craddock et al, 2012). The SWC cognitive deficit. measures were computed using Brain connectivity (BCT) toolbox. The investigators computed the clustering coefficient ‘C’, the It was a single institutional prospective study. The investigators characteristic short path length ‘L’ and the small-world coefficient included patients who had suffered from HSE in the past PCR
166 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 positive or positive for HSV IgG antibody in CSF (Titres>625). 37. Clinical characteristics, endovascular treatment and Nine patients and 15 age-gender matched controls were recruited. outcome of patients with intracranial pial arteriovenous MRI was performed in a 3T scanner using axial T2W, FLAIR, SWI, fistulae. Dr. Gorky Medhi. Guides: Dr. AK Gupta, Dr. T1MPRAGE and 16 direction DTI. Neuropsychological assessment Hima Pendharkar, Dr. Arvinda HR, Dr. Jitender Saini was conducted using selective subtests of the Wechsler Memory Scale. The objectives of the study are (i) to describe the clinical features Significantly (p<0.05 [FWE corrected]) decreased FA was noted in and endovascular management of pial arteriovenous fistulae at corpus callosum, corona radiatae, left posterior thalamic radiation, various intra cranial locations (ii) to analyze the use of liquid cingulum, superior longitudinal fasciculus, fornix, inferior longitudinal embolic agents and coils alone or in combination in treatment fasciculus, inferior fronto occipital fasciculus, uncinate fasciculus. of pial arteriovenous fistulae and (iii) to analyze the outcome of Impaired face recognition significantly correlated with reduction in embolization. FA of right uncinate fasciculus, right inferior longitudinal fasciculus, and splenium and genu of corpus callosum. FA value of left cingulum Retrospective review of a diagnostic angiography and significantly correlated with logical memory, auditory verbal learning. neurointerventional data baseof our institution identified a cohort of FA value of fornix correlated with visual recognition and FA value 15 patients with non galenicpial AVF fromJanuary 2008 to November of left uncinate fasciculus with auditory verbal learning and delayed 2014 out of 6750 patients recall. A total of 14 patients with intracranial pialarteriovenous fistulas The study demonstrated microstructural abnormality in several were treated with endovascular embolization. One patient showed white matter tracts compared to healthy controls. All these tracts spontaneous obliteration of the fistula just prior to interventional and structures are functionally related to visual or verbal learning and procedure. Of these 9 (60%) were male patients and 6 (40%) were memory, memory for faces directly or indirectly. female. Age of the patients ranged from 3 to 37 years. Headache and seizures were the predominant presenting complaints. Venous drainage Representative images: was into superficial venous system in 12 cases and deep venous system in three cases. A total of 14 patients were treated endovascularly with coils/NBCA/Onyx – alone or in combination. Complete occlusion of the fistula was achieved in 85.7% patients and downgrading of the fistula was achieved in one patient.
Pial AVF is a rare vascular malformation that leads to a high morbidity and mortality. Adequate treatment with DTI-TBSS analysis showing areas of significantly (p<0.05 family-wise error flow disconnection is associated with good clinical outcome. corrected) decreased FA (red) in post herpes simplex encephalitic subjects compared to healthy controls. FA-fractional anisotropy. Endovascular treatment with liquid embolics, coils alone or in combination is a safe, viable and effective method. Complete occlusion of the fistula can be achieved in most cases in a single sitting with a reasonable morbidity related to the procedure, compared with the natural history of this disease.
Representative Image:
VBM result showing gray matter volume reduction involving left parahippocampal gyrus, middle , inferior temporal gyrus, cingulate gyrus. Pre-embolisation Post Embolisation (Uncorrected p<0.001 at voxel level. Cluster extent threshold 20 voxels)
National Institute of Mental Health and Neuro Sciences 167| Annual Report 2014-15
38. Clinical characteristics, imaging features and endovascular 41. Study of functional connectivity in febrile seizures using management of spinal dural arteriovenous fistulae. Dr. resting state fMRI. Dr. Ullas VA. Guides: Dr. AK Gupta, Dr. Subhendu Parida. Guide: Dr. AK Gupta, Dr. Hima Rose Dawn Bharath, Dr. Jitender Saini, Dr. Bindu PS Pendharkar, Dr. Arvinda HR, Dr. Jitender Saini This will be a prospective observational study, which is to be done Spinal dural arteriovenous fistula is a male predominant disease, with minimum 10 cases each of simple and complex febrile seizures commonly presenting with lower limb weakness leading to difficulty within age group of six months to five years. The aim of the study in walking. It can be diagnosed and characterized by MRI, however is to compare resting state functional connectivity patterns between catheter angiography remains the gold standard. They can be very patients of simple febrile seizures and complex febrile seizures. The effectively treated with endovascular embolization using liquid main objective is to study the difference in various known resting state embolic agents. Pre-procedure Aminoff-Logue gait score had networks between patients suffering from simple and complex febrile significant association with the post procedure outcome. seizures using resting state fmri.
39. Diffusion tensor evaluation of white matter integrity in patients with history of inhalant abuse. Dr. Subhendu Parida. Neurological Rehabilitation Guides: Dr. AK Gupta, Dr. Rose Dawn Bharath, Dr. Jitender Saini, Dr. Prabhat Chand 1. Study of sexual dysfunction and sexual concerns among persons with disability due to myelopathy; assessment of The study was aimed at characterizing the diffusion abnormalities in unmet need for rehabilitation services and development of a 9 patients with history of inhalant abuse compared with age matched hospital based sexual rehabilitation package. Investigators: controls. The investigators correlated the duration and pattern of use Dr. Meeka Khanna, Dr. Anupam Gupta, Dr. AB Taly with the extent of diffusion abnormalities using fractional anisotropy (Funding by ICMR) and mean diffusivity. Comprehensive neurological rehabilitation should address sexual Compared to matched healthy controls patients with inhalant abuse function of affected individual to allow them highest level of function revealed widespread changes, most importantly there was reduced and quality of life. Sexuality of disabled people is not considered FA in the left uncinate fasciculus (Fig A), fornix (Fig B) and inferior important and only a few studies have explored this issue in India. longitudinal fasciculus (Fig C). Longitudinal studies are needed to This study aims to assess the sexual dysfunction and sexual concerns address the issues of progression and reversibility following abstinence. among patients with myelopathy attending rehabilitation unit of a tertiary care hospital. At the end of study, the investigators expect to be able to describe; the type of sexual dysfunction in persons with disability due to myelopathy; the various sexual concerns that these persons have; and the specific but unmet need for care for sexual dysfunction among these males and females. The investigators would also develop a rehabilitation package for Indian set-up, enlisting the above findings, and that would help rehabilitation clinicians to address the sexual dysfunction needs of the persons with disability due to myelopathy.
40. Longitudinal brain connectivity markers in patients with 2. Comparison of antipsychotics for non-neurological adverse acute traumatic paraparesis. Dr. Shriram Varadharajan. effects- Pilot study. Investigator: Dr. Anupam Gupta Guides: Dr. AK Gupta, Dr. Rose Dawn Bharath, Dr. Anupam (NIMHANS Intramural Funding) Gupta, Dr. B Indira Devi This research aims to examine patients with psychotic disorder This will be a prospective observational study, which is to be done with who are started on monotherapy with Chlorpromazine, Clozapine, minimum 15 post traumatic SCI patients presenting with paraparesis Olanzapine or Risperidone in either in-patient or out-patient setting (below D1), from both the genders with age ranging from 18 to 45 in prospective manner for a period of 14 weeks to assess the pattern years. The aim of the study is to test whether baseline resting state and time-course of antipsychotics emergent adverse effects including connectivity analysis of various networks of the brain can be used as sexual effects, enuresis and postural hypotension and explore a biomarker for prognostication of spinal cord injury (SCI) patients. urodynamic parameters of antipsychotics emergent enuresis.
168 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
3. Prevalence of fatigue in Guillain Barre Syndrome - A follow- Eight male patients with mean age 43.1 years (28-58 years), mean up study. Investigators: Dr. Meeka Khanna, Dr. AB Taly, Dr. duration of symptoms 19 months (6-36 months), 7 ischemic and 1 Anupam Gupta, Dr. Madhu Nagappa hemorrhagic stroke, lesion side left hemisphere in 6 and right in 2 cases, were recruited. No dropouts were recorded and no complications 4. Functional recovery and Ambulation in patients with Stroke: observed. Robot hand therapy is a safe and feasible treatment option Impact of inpatient rehabilitation. Dr. H. Sankaranarayanan. for hand motor recovery in chronic stroke patients. Guides: Dr. Anupam Gupta, Dr. Meeka Khanna, Dr. AB Taly Neurology
The purpose of present study is to determine the prognostic factors of 1. Innovations in mental health and neurosciences: Manpower ambulatory potential and functional recovery in stroke rehabilitation development and translational research Centre for Advanced and also to study the effect of rehabilitation interventions (orthosis Research. Investigators: Dr. P Satishchandra, Dr.TR Raju, and Botulinum toxin) on walking and functional outcome after stroke. Dr. SK Shankar, Dr. Sarada Subramanian (Funding by It is a prospective study among stroke patients, admitted under the ICMR, New Delhi) Department of Neurological Rehabilitation, NIMHANS, between August 2014 and May 2015, fulfilling inclusion criteria. 2. Automated portable EEG system – along with Axxonet System Technologies. Investigators: Dr. P. Satishchandra, 5. Study of autonomic functions and pulmonary functions in Dr. Sanjib Sinha, Mr. Chetan Mukundan, Axxonet System Guillain Barré Syndrome. Dr. Nidhi Rawat. Guides: Dr. Technologies, Bangalore (Funding by Biotechnology Meeka Khanna, Dr. Anupam Gupta, Dr. Sathyaprabha TN, Industry Research Council, a Government of India Dr. Madhu Nagappa Enterprise)
The objective of the study is to assess autonomic functions in patients 3. Lafora body disease – Role of Malin and ubiquitin protisome with Guillain Barre Syndrome (GBS) and to evaluate pulmonary pathway in the pathogenesis. Investigators: Dr. Nihar Renjen function in these patients. It is a prospective, cross-sectional study Jena. Dr. P Satishchandra, Dr. Sudeendra Rao, NBRC, New in GBS patients, admitted under the Department of Neurological Delhi (Funding by DST) Rehabilitation (DNR), NIMHANS, Bengaluru, between the period October 2014 to May 2015, fulfilling inclusion criteria. All patients 4. Subregional cytoarchitectural changes and cell dysregulation would undergo Autonomic and Pulmonary function tests. in temporal lobe epilepsy. Investigators: Dr. Lily Pal, SGPGI, Lucknow, Dr. P Satishchandra, Dr. SK Shankar (Funding by 6. Effectiveness of robotic hand training in patients with stroke. DST) Dr. Nidhi Rawat. Guides: Dr. Meeka Khanna, Dr. Anupam Gupta 5. TMS as a biomarker to differentiate cortical dementias. Investigator: Dr. SR Chandra The objective of the study is to evaluate the efficacy of robot-assisted therapy in hand function recovery in stroke patients. Transcranial magnetic stimulation showed central motor conduction time prolonged in fronto temporal dementias. There was evidence The prospective, interventional study involved adult chronic stroke for increased cortical excitability and decreased cortical inhibition as patients at their first-ever stroke, with at least 3 months duration, evidenced by reduced silent period with escape discharges suggesting ischemic or hemorrhagic stroke. Treatment was performed using asymptomatic changes in the gabanergic system in these patients Amadeo robotic system (Tyromotion GmbH Graz, Austria). Each opening the role of the therapeutic role of GABA agonists in addition patient received, in addition to standard rehabilitative treatment, 15 to serving as a biomarker in early diagnosis. In patients with AD, sessions (30 minutes each) of robotic treatment for threeconsecutive CMCT was normal but cortical inhibition was reduced. weeks (5 days/week). The therapy included passive modality (10 minutes), passive-plus modality (10 minutes), and assisted therapy 6. Genetic determinants of Cognitive impairment in cerebral (10 minutes). Impairment evaluation was done using upper extremity small vessel disease. Investigators: Dr. SR Chandra, Dr. Rita Fugl-Meyer scale (UEFM) and muscle strength was assessed with Christopher (Funding by ICMR) Medical research council (MRC) scale, at the beginning (T1) and at the end of treatment (T2). The hand flexion and extension strength A total of 107 patients diagnosed with cognitive impairment due to performed by robot were assessed at T1 and T2. SVD and 100 controls having SVD but with normal cognition were investigated for the presence of SNPs in RAAS (renin-angiotensin-
National Institute of Mental Health and Neuro Sciences 169| Annual Report 2014-15 aldosterone system) associated genes and endothelial nitric oxide 12. Towards identification of novel genes for reflex epilepsy (hot synthase gene. No significant difference was observed inACE I/D, water epilepsy) triggered by tactile and temperature stimuli. cyp11b2 -344t/C, AT1R 1166A/C, and eNos (4b/4a, 786t/c, and Investigators: Dr. A Anand, JNCASR, Dr. S Sinha, Dr. P 894g/t) genotype distribution in cases compared to controls, except Satishchandra (Funding by ICMR) for the presence of TT genotype (eNos 894g/t) only in cases (6%). Comparison of genotype distribution in cases and with cognitive 13. Respiratory chain disorders: Phenotypic genotypic and scores (HMSE & NNPB) and Fazekas grade also did not show any functional correlations. Investigators: Dr. Bindu PS, Dr. AB significant variation. Statistical significance was observed in cases Taly, Dr. Gayathri N, Dr. Srinivas Bharath MM, Dr. Meera to control for the presence of depression and behavioral problems Purushotham (Funding by ICMR) (7.14/0, P value 0.0088; 16.32/2.17, p value 0.0009 respectively). Increased ACE activity was observed in subjects with ACE DD 14. Paediatric anti-NMDAR encephalitis: A clinical, genotype in comparison to II and ID genotype subjects (DD-33.16, electroencephalographic and follow up study. Investigators: ID-25.32, II-19.81U/L, p<0.05).No significant difference in both Dr. Bindu PS, Dr. Madhu N, Dr. AB Taly, Dr. Sinha S, Dr. ACE activity and plasma NOx levels were observed in cases compared Anita Mahadevan to controls. Further studies are being carried out to elucidate the genetic determinants of cerebral SVD. The research project aims to study the clinical features with specific reference to involuntary movements, electroencephalographic profile 7. Factors determining course and prognosis in tuberculous and therapeutic response to immunomodulatory agents in cohort of meningitis. Cognitive functions in Idiopathic Parkinsonism. children with NMDAR encephalitis, an important cause of childhood Investigators: Dr. Sikandar Adwani, Dr. SR Chandra, Dr. PK encephalopathies. The study has so far recruited 13 paediatric patients Pal, Dr. Ravi Yadav, Dr. Keshav, Dr. Ravikumar with anti-NMDR encephalitis.Abnormal behaviour, global regression, and seizures were universal. Movement disorder was characterised by Patients with culture positive TBM, multiple co-morbidities, extremes hyper-kinetic large amplitude, complex, multi-directional movements of age and intermittent therapy, drug toxicity necessitating shift to involving limbs and oro-facial musculature. EEG was abnormal in substitute regimes and presence of lesions in the cisternal spaces all; abnormalities persisted following recovery from altered sensorium. adversely influenced the outcome. Most persons with Parkinsonism All received intravenous methyl prednisolone. Sub-therapeutic had executive function defect but it was not influenced by the side of response during the acute illness necessitated plasmapheresis in onset of the disease. six and intravenous immunoglobulin in two. Monthly pulsed methyl prednisolone was administered to maintain remission. All 8. Glucocerebrosidase mutation in Parkinson’s disease. improved substantially from the acute illness; altered sensorium and Investigators: Dr. Pramod Kumar Pal, Dr. Ravi Yadav involuntary movements ceased. Ten patients were followed up for a (Funding by DBT median duration of 10.30+6.7 months. Residual symptoms included hypersomnolence, hyperphagia, hyperactivity, over-familiarity, Approximately 350 patients with Parkinson’s disease have been among others. The results suggest that Anti-NMDAR encephalitis recruited. The genetic analysis is in progress. requires prolonged immunomodulatory therapy. Intravenous pulsed methyl prednisolone therapy is effective in inducing and maintaining 9. Genetics of movement disorders: Genotype-phenotype remission. The duration of treatment needs to be determined in long- correlates in ataxias and Huntington’s disease. Investigator: term studies. Dr.Pramod Kumar Pal (Funding by ICMR) 15. PLA2G6- associated neurodegeneration: A phenotypic and More than 100 patients of Spinoccerebellar Ataxi and Huntington’s genetic study. Investigators: Dr. Bindu PS, Dr. AB Taly, Dr. disease have been recruited. Genetic testing is going on. Madhu N, Dr. Sinha S, Dr. Anita Mahadevan, Dr. Yasha TC, Dr. Gayathri N, Dr. Rose Dawn Bharath 10. Gray and white matter correlates of REM sleep behavior disorder and psychosis in Parkinson’s disease. Investigator: Infantile neuroaxonal dystrophy (INAD) is a rare autosomal recessive Dr. Pramod Kumar Pal (Funding by ICMR) neurodegenerative disorder that presents within the first two years of life. Mutations in the PLA2G6 gene, encoding a calcium 11. Development of Intra-operative ECoG and depth recording independent phospholipase A2 enzyme that catalyses the hydrolysis electrodes for surgery for refractory epilepsy - part 1. of glycerophospholipids, were identified in patients with INAD from Investigators: Dr. S Sinha, Dr. P Satishchandra (Funding by several countries. However, there is no report on the genetic analysis of DEBEL/SBMT) INAD from India. DNA sequence analysis of the entire coding region
170 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
of the PLA2G6 gene in 23 families identified 14 different mutations cramp by quantitative characterization of ocular movements in 13/23 (56.52%) families, including nine novel ones. Interestingly, and eye-hand coordination and advanced neuroimaging one patient was homozygous for two different mutations, and thus techniques. Investigators: Prof. Pramod Kumar Pal, Dr. K harboured four mutant alleles. With these mutations, the total number Thennarasu, Dr. Jitender Saini, Dr, Ravi Yadav (Funding by of mutations in this gene reaches to 130. The absence of mutations in DBT) 10/23(43.48%) families suggests that the mutations could be in deep intronic or promoter regions of this gene or these families could have 22. Serial estimation of inflammatory markers in serum of mutations in an unknown gene. Guillain Barre Syndrome patients to predict ongoing disease activity and recovery. Investigators: Dr. R Subasree, Dr. 16. Magnetoencephalography observations in Sub-acute Rita Christopher, Dr. M Veerendrakumar, Prof Neurology Sclerosing Pan-encephalitis. Investigators: Dr. Madhu (NIMHANS Intramural Funding) Nagappa, Dr. Sanjib Sinha, Dr. Bindu PS, Dr. AB Taly 23. Spectrum of autoantibody expression in generalized 17. Kerala-einstein study: Healthy lifestyle, vascular disease, myasthenia gravis: Clinical phenotype and immunological and cognitive decline. Investigators: Dr. PS Mathuranath, correlation. Investigators: Dr. Madhu Nagappa, Dr. Anita Dr. Joe Verghese (Funding by National Institute of Health Mahadevan, Dr. Shripad Patil, Dr. AB Taly (NIMHANS (Funding by NIH) Intramural Funding)
18. MDS-UPDRS (Movement Disorder Society-Unified Myasthenia gravis (MG) is an immune mediated disorder Parkinson’s disease rating Scale): Hindi translation and its characterized by fatigable weakness of skeletal muscles. validation. Investigators: Dr. Ravi Yadav, Dr. Pramod Kumar Heterogeneity in the age at onset, disease expression, associated Pal thymic histology, severity of muscle involvement and response to treatment in MG are recognised. This depends on the expression 19. Genetic Analysis of the Beta-glucocerebrosidase gene in patterns of specific autoantibodies which forms the basis of South Indian patients with Parkinson’s disease. Investigators: classification of MG into immunologically distinct subtypes. Prof. Arun Kumar (IISc), Prof. Pramod Kumar Pal, Dr. Ravi Majority of patients are positive for antibodies to acetylcholine Yadav, (Funding by DBT) receptor. Several other auto-antibodies are expressed in these patients with ‘seronegative’ MG. In this project, the investigators intend to study the GBA mutations in Indian patients with Parkinson’s disease. More than 300 patient and The proposed study will investigate the auto-antibody profile in control samples have been collected, and the analysis is in progress. patients with generalized MG, including antibodies to AChR, MUSK, titin, and ryanodine receptor. Classification based on the 20. The role of metals in the etio-pathogenesis of Parkinson’s auto-antibody status will not only help to define the clinical subsets disease. Investigators: Dr. Pramod Kumar Pal, Dr. Rita of MG in our cohort, but also help in tailoring therapy and predicting Christopher, Dr. Ravi Yadav, Dr. Jitender Saini, Dr. Rose the prognosis. Dawn Bharath (Funding by DBT, New Delhi) 24. Magnetoencephalography observations in Sub-acute This is a multi-institutional project aimed at studying the role of Sclerosing Pan-encephalitis. Investigators: Dr. Madhu metals in the etiopathogenesis of Parkinson’s disease. A total of 100 Nagappa, Dr. Sanjib Sinha, Dr. Bindu PS, Dr. AB Taly patients with Parkinson’s disease and 85 controls were recruited till March 2014. Each patient’s motor and non-motor symptoms were 25. Genetics and Epilepsy. Investigator: Dr. P Satishchandra evaluated using different Parkinson’s disease rating scales. Markers of oxidative stress have been studied by the assay of ferric reducing Following projects are being undertaken in collaboration with the ability of plasma (FRAP) and serum malondialdehyde. Patients had Molecular Genetics Department of Jawaharlal Nehru Center for higher serum malondialdehyde levels compared to controls. Patients Advanced Studies at Bangalore: After getting two loci for this had MRI analysis for detection of iron/metal deposition in the brain unique type of reflex epilepsy; Hotwater Epilepsy – one Chromosone showed significant atrophy mainly in the caudate nucleus, thalamus 10q21-23 and another at 4q 24-28. The investigators are continuing and cingulate gyrus. the next phase of Gene hunting in these regions. They have recently identified gene – Glutamate Transporter gene for the causation of 21. Exploring subclinical cerebellar dysfunction in patients Hot-Water epilepsy on chromosome 9q. Further work is going on with essential tremor, primary writing tremor and Writer’s this direction.
National Institute of Mental Health and Neuro Sciences 171| Annual Report 2014-15
Pharamaco-genetics is an upcoming field in epilepsy. They have started C infection’. Interesting association with HIV and Sino-Venous the research work in looking at ‘Pharmaco Genetics of Intractable thrombosis, Lymphoma and Neurosypilis has been established. Seizures’ and ‘Genetics of Refractoriness of Epilepsy’ in collaboration with JNCASR, Bangalore and Institute of Bio Informatics, Bangalore. Another interesting area is ‘Neuro IRIS’. This is a new area yet to be understood among the scientific community. The investigators are 26. Pregnancy and Epilepsy. Investigator: Dr. P Satishchandra finding cases of patients with their condition worsening on HAART with very high CD4 cell count – a paradoxical reaction. Cases of This is one of the commonly debated problems. Owing to the TBM, Tuberculoma, Cryptococcus Meningitis, PML, etc. have been problems involved in this area, and sparse literature especially from found. The project is being taken up this year as a new initiative for India, the investigators are looking at the teratogenicity of AEDs, and further study. successful pregnancy among epileptics. 31. Role of renin-angiotensin-aldosterone system in cognitive 27. Reflex Epilepsy. Investigator: Dr. P Satishchandra deterioration in patients with cerebral small vessel disease. Dr. Thomas Gregor Issac. Guides: Dr. Chandra SR, Dr. Rita Reflex epilepsies are interesting variety of seizures/epilepsy classified Christopher, Dr. Jamuna Rajeswaran, Dr. Mariamma Philip as a separate group under the proposed International classification (Funding by part of ICMR) of seizures/epilepsy. These could be used as a model for further understanding the mechanism of epilepsy in general. Hence a study The objectives of this research are to study the phenotypic characteristics has been undertaken to evaluate these reflex seizures by Autonomic of cerebral small vessel disease, correlate the same with imaging and function tests, Electrophysiological followed by Inter Ictal/ ictal neuropsychological parameters and to determine the association of SPECT scan. This would help in the process of understanding the gene polymorphisms of the renin-angiotensin-aldoseterone pathway pathophysiological mechanisms. in determining the progression of cognitive symptoms. Blood samples of patients are being collected and processed and initial and follow- 28. Autonomic nervous system and hot water Epilepsy. up neuropsychological assessments for executive dysfunction are being Investigator: Dr. P Satishchandra carried out on the recruited patients.
Hot water epilepsy an interesting variety of reflex seizures is being 32. Phenotypic spectrum of patients with mitochondrial studied for more than two decades. Currently, the investigators are respiratory chain enzyme deficiencies. Dr. Rakesh Kumar. exploring the role of Autonomic Nervous system and HWE, with a Guides: Dr. AB Taly, Dr. PS Bindu, Dr. N Gayathri, Dr. HR hope that this must be playing an important role in its causation. Arvinda, Dr. MM Srinivas Bharath
29. CJD Registry. Investigator: Dr. P Satishchandra The current study aimed to evaluate the phenotypic spectrum in patients with various respiratory chain enzyme deficiencies. This is an ongoing project in collaboration with the Department of Patients (n=53) with clinical features consistent with diagnosis Neuropathology at NIMHANS. Initially it was funded but now it of mitochondrial cytopathies (Modified Walker’s criteria) with is a non-funded project. This registry includes probable and definite muscle biopsy showing evidence of respiratory chain enzyme CJDs confirmed histopathologically. The investigators are also part of deficiency were analyzed. The patient samples were subjected to ‘Surveillance of CJD in India’ under the Ministry of Health. genetic analysis, histological and biochemical assays. Approximately 60% of the patients showed isolated complex I deficiency. But the 30. HIV and Nervous system. Investigator: Dr. P Satishchandra correlating phenotype significantly varied among the patients. The study concluded that respiratory chain assays helped in (i) defining This is an ongoing project. So far, more than 1500 patients with non-syndromic mitochondrial disorder (ii) improved diagnosis Neuro AIDS / HIV infection are being evaluated at NIMHANS. compared to histopathology (iii) authenticating novel mitochondrial Nearly 140 autopsies have been carried out in collaboration with the mutations. Department of Neuropathology. These materials are being processed and analyzed to understand various OIs. The data on Cryptococcal 33. Sleep profile in myasthenia gravis (MG): A questionnaire and meningitis, and work on Toxoplasmosis, PML have already been polysomnography based study. Dr. Rakesh Kumar. Guides: published. CNS Tuberculosis associated with HIV infection is being Dr. AB Taly, Dr. Sanjib Sinha, Dr. Madhu Nagappa (Partly studied. The investigators have just completed a non-funded study funded from the Department of Neurology Golden Jubilee of ‘An approach to focal brain lesions associated with HIV clade Fund)
172 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
In this prospective, cross-sectional hospital based study, 50 adults GuillainBarré Syndrome (GBS) is the commonest cause of acute of MG were evaluated by sleep questionnaires and overnight PSG. neuropathy. Despite timely treatment, about one-fourth develops Factors determining sleep quality and sleep architecture were life threatening respiratory paralysis and one-tenth die. It is widely evaluated by comparing with age and gender matched controls. The accepted that GBS is an autoimmune disorder, the antigenic targets mean PSQI and ESS were similar in cases and controls. However, being gangliosides of peripheral nerves. However, antibodies to patients with MG had higher prevalence of disturbed sleep compared gangliosides are found in only a proportion of patients, and that too to controls (p: 0.005). Sleep architecture was altered in patients (n=25) those with axonal form of GBS. It is also perplexing that a specific during overnight PSG recording compared to controls: reduced sleep antigenic target has not been identified in demyelinating form of efficiency, increased latency to onset of N1 and REM, and increased GBS, although acute inflammatory demyelinating polyneuropathy arousals, but this did not affect their quality of life scores. (AIDP) is the commonest form of GBS worldwide.
34. Multi-modal evoked responses and source localization using Gangliosides that co-localise have the tendency to cis-interact and MEG in Wilson disease. Dr. Aruna Ramani K. Guides: form clusters in the plasma membrane. Here, the carbohydrate moieties Dr. AB Taly, Dr. Sanjib Sinha, Dr. Madhu Nagappa (Partly of gangliosides interact with one another to form novel epitopes funded from the Department of Neurology Golden Jubilee called ‘Ganglioside Complexes’ (GSC). This study is based on the Fund) hypothesis that GSCs are the antigenic targets in GBS, particularly AIDP. As a part of this study, 125 patients of GBS will be recruited Wilson’s disease is a prototype of young onset extrapyramidal disorder prospectively. The study aims to study expression of anti-GSC characterized by excessive accumulation of copper in the brain and antibodies, and correlate with specific clinico-electrophysiological has myriad neurological manifestations. Sensory symptoms and signs subtypes, severity, and outcome at hospital discharge will be drawn. are rare but abnormalities in evoked responses to visual, auditory This study is expected to improve our understanding on the role of and somatosensory stimuli and central motor conduction time are anti-GSC antibodies in pathogenesis of GBS. recognized in Wilson’s disease. This provides evidence for subclinical involvement in Wilson’s disease. MEG based evoked field study is 37. Sleep in drug resistant temporal lobe epilepsy - A sleep a more sensitive technique, that may define abnormalities in various questionnaire and polysomnography based study. Dr. Sai cerebral pathways with greater accuracy. Deepak Yaranagula. Guides: Dr. Sanjib Sinha, Dr. AB Taly, Dr. Madhu Nagappa (Funding by Department of Neurology Patients with biochemically and/ or genetically proven Wilson Golden Jubilee Fund) disease are being prospectively recruited with the aim of defining abnormalities in sensory and motor pathways in patients with 38. Neurologic sequelae of Neonatal Hypoglycemic injury: A Wilson’s disease using electrophysiological techniques like Multi- clinical, electroencephalographic and imaging study. Dr. modal Evoked Potentials and Magnetoencephalography (MEG). Dipesh Pimpale. Guides: Dr. Bindu PS, Dr. Rose Dawn The abnormalities in latencies and amplitudes of the major Bharath components of the evoked responses will be analyzed and compared with age and gender matched healthy controls. Co-registration Neonatal hypoglycemia results in various forms of neurological and source localization of magnetic evoked fields will be done with disability in children which include mental retardation, visual Magnetization-Prepared Rapid Acquisition GRE (MP RAGE) impairment, autistic spectrum disorders and refractory epilepsy. A sequence obtained using 3Tesla MRI machine. Cortical source characteristic pattern of parieto occipital gliosis on magnetic resonance localisation of the major components of the evoked responses will be imaging often points to the diagnosis. This study intends to analyse done. An attempt will be made to correlate these observations with the different clinical manifestations, EEG features and magnetic clinical severity and brain MRI findings. resonance imaging findings in a cohort of children with history of neonatal hypoglycemia. This study is expected to derive a data on the 35. Sleep profile in patients with idiopathic generalized and neurological disability caused by neonatal hypoglycemia which may symptomatic partial epilepsies. Dr. Saraswati Nashi. Guides: be used for better preventive measures. Dr. Sanjib Sinha, Dr. AB Taly, Dr. Madhu Nagappa. 39. Leukoencephalopathies in childhood: A phenotypic and 36. Anti-Ganglioside complex antibodies in GuillainBarré magnetic resonance imaging study. Dr. Dipesh Pimpale. syndrome-A Clinical, electrophysiological and Guides: Dr. Bindu PS, Dr. Rose Dawn Bharath immunological correlative study. Dr. Wahatule Rahul. Guides: Dr. AB Taly, Dr. Anita Mahadevan, Dr. Monojit Leukoencephalopathies in childhood encompass a wide spectrum Debnath, Dr. Madhu Nagappa of disorders in which predominantly or exclusively white matter is
National Institute of Mental Health and Neuro Sciences 173| Annual Report 2014-15 affected and usually lead to progressive intellectual and neurological with a wide range of phenotypes, complicating the scenario for a deterioration. Despite a high incidence of leukoencephalopathies in clinician. This calls for genetic validation of the suspected phenotype South India, there are no systematic studies on this subject in Indian to affirmatively diagnose POLG related disorders. In a tertiary set context till now. This study aims to analyse the phenotypic and magnetic up such as ours, with mitochondrial research growing fast, it would resonance imaging characteristics of various leukoencepahlopathies be one more step forward, to study the genotypic and phenotypic seen in children. correlates of POLG related disorders.
The data is expected to give an overview of the different types of leu- 43. The role of aquaporin antibodies in the diagnosis and koencephalopathies seen in children from South India which may be management of neuromyelitisoptica and other central useful in the early diagnosis, prognostication and genetic counseling demyelinating disorders. Dr. Deepa N. Guide: Dr. P in these children. Satishchandra, Dr. Anita Mahadevan, Dr. Rose Dawn (Funding by IAN) 40. Mitochondrial respiratory chain disorders: Phenotypic, genotypic and functional correlation. Dr. Sonam Kothari. Neuromyelitisoptica (NMO) is an idiopathic, severe, demyelinating Guides: Dr. Bindu PS, Dr. Taly AB, Dr.Gayathri N, Dr. disorder of the central nervous system that preferentially affects Srinivas Bharath MM the optic nerve and spinal cord. It is being encountered more frequently from India with a significant proportion being earlier Mitochondrial respiratory chain disorders (RCD) are known for diagnosed as Asian variety of optico spinal MS. Discovery of Anti- phenotypic, biochemical and genetic heterogeneity. This ongoing Aquaporin 4 antibody serum as specific biomarker for diagnosis study in collaboration with the Departments of Neuropathology and of NMO has been useful in differentiating NMO from multiple neurochemistry has successfully established the respiratory chain sclerosis and other demyelinating disorders. The study revealed complex assays for patients with suspected mitochondrial disorders. polyphasic course, bilateral optic nerve involvement and complete Over the last two years, a large cohort of patients with both syndromic cord syndrome was frequently seen in NMOSD cohort and had and non-syndromic mitochondrial disorders has undergone the high predictive value. Imaging features clearly discriminated phenotypic assessment and biochemical assays. The most common NMOSD cohort from RRMS cohort. Brain abnormalities in deficiency observed was complex 1 and IV followed by combined hypothalamus, peri-aqueductal grey matter and subcortical WM enzyme deficiency. white matter was seen frequently in NMOSD cohort and this unique topographic distribution coinciding with Aquaporin 4 41. Genetic characterisation of respiratory chain disorders in channels expression highlights the distinct pathogenetic mechanism pediatric population. Dr. Shwetha Chiplunkur Guides: Dr. of NMO. Aquaporin-4 autoantibody positivity (NMO-IgG) had Bindu PS, Dr. Taly AB, Dr. Gayathri N, Dr. Srinivas Bharath high specificity for NMOSD as compared to RRMS cohort. MM 44. The role of iron in the etiopathogenesis of Parkinson’s Diagnosing mitochondrial disorder is a challenge to the clinician. disease. Ms. Rajini NM. Guides: Dr. Pramod Kumar Pal, Dr. Routine biochemistry, respiratory enzyme assays and genetic analysis Rita Christopher, Dr. AK Gupta, Dr. Rose Dawn Bharath form the investigatory battery for mitochondrial disorders. The (Funding by DBT (part of a funded large project ) investigators are already successful in functionally assessing complexes of mitochondrial electron transport chain. A more obvious next step is This is an attempt to understand the role of iron in the pathophysiology to confirm the dysfunction by providing a genetic validation. Since all and molecular events underlying neurodegeneration in Parkinson of mitochondrial dynamics is run by mitochondrial and nuclear genes, disease. This study deals with comparing possible disease markers it is important to analyse both. In the purview of available resources, (serum levels of iron, oxidative stress markers and advanced MRI identifying deletions and depletions in mitochondrial genome, for detection of iron) in a comprehensive way in a large cohort of with few known, nuclear gene mutations affecting mitochondrial Parkinson disease patients in a case- control manner, and to correlate functioning are aimed at in collaboration with molecular genetics lab. the findings with the clinical findings.
42. Phenotypic and genotypic correlation of POLG related 45. Adenosine signaling pathway in medically refractory disorders. Dr. Chetan Kashinkunti. Guides: Dr. Bindu PS, epilepsy due to mesial temporal sclerosis (MTS) Dr.Gayathri N, Dr.Thangaraj lesions. Dr. Vikas Dhiman. Guides: Dr. Sanjib Sinha, Dr. P. Satishchandra, Dr. Anuranjan Anand, Dr. Anita POLG (Polymerase gamma) mutation has recently evolved as one of Mahadevan, Dr. Arivazhagan A (Funding by ICMR the most common cause of mitochondrial dysfunction. It presents (partial support))
174 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
The aim of this study is to find the role of various genes involved samples is at final stage. The ideal antigen suitable for the kit is in the adenosine signaling pathway Adenosine kinase, A1 receptor, being prepared indigenously and used. This lateral flow assay is 5’nucleotidase, adenosine deaminase, c-myc, c-fos, c-jun, CREB1, promising but there are some short comings at the moment mainly ERK1/MAPK1, NF-kB), in medically refractory epilepsy due to fake negativity. The investigators are in the process of fixing the above MTS using surgically resected hippocampal tissues from patients of problem so that the kit would be in a better shape. MTS. Expression profile of these genes will also be tested in blood samples of the patients in an attempt to find biomarkers for prognosis. 2. Whole genome sequencing analysis of mycobacterium tuberculosis clinical isolates from extra pulmonary 46. Sleep symptoms and polysomnographic features in hereditary tuberculosis patients. Investigators: Dr. R Ravikumar, Dr. ataxias: A prospective study. Dr. Seshgiri. Guides: Dr. Ravi P Satishchandra, Dr. Keshava Prasad, Dr. Akhilesh Pandey Yadav, Dr. Pramod Pal, Dr. Bindu M Kutty (Funding by DBT)
The present study is to identify and to characterize the sleep 3. Genomic and proteomic analysis of chronic meningitis. disturbances in patients with genetically positive spinocerebellar Investigator: Dr. R Ravikumar (Funding by DBT) ataxias (SCA 1,2,3). Patients with progressive ataxia were identified and assessed clinically. Disease severity measured with International 4. Etiopathogenesis of chronic meningitis: Biochemical Ataxia Rating Scale (ICARS) scale. Sleep quality was assessed with analysis and molecular characterization of M. tuberculosis Pittsburgh Sleep Quality Index (PSQI), Mayo Sleep Questionnaire and C. neoformans in CSF of patients. Investigator: Dr. R (MSQ), Epworth Sleepiness Scale(ESS).Genetically confirmed cases Ravikumar (Funding by ICMR) underwent overnight Polysomnography (PSG) . Almost all patients (n=15) reported good quality of sleep during the interview. However, The investigators performed a comprehensive proteomic analysis of on PSG many REM sleep abnormalities were observed with a mean C. neoformans var. grubii (Serotype A), which is the most virulent REM%: 5.96.There was total absence of REM sleep states in two variety, in order to provide protein-level evidence for computationally patients, with both of them having high ataxia scores. Good REM predicted gene models and to refine the existing annotations. They sleep percentage (16.84) was reported in a patient with best ataxia confirmed the protein-coding potential of 3,674 genes from a total score. of 6,980 predicted protein-coding genes. They also identified 4 novel genes and corrected 104 predicted gene models. In addition, the studies led to the correction of translational start site, splice junctions and reading frame used for translation in a number of proteins. Finally, the investigators validated a subset of our novel findings by RT-PCR and sequencing. In this study, an in-depth proteomic profiling of C. neoformans var. grubii, the most virulent form among C. neoformans variants was carried out. The investigators have provided protein- Hypnogram of patient with Absent REM Sleep states in a SCA 2 patient, ICARS coding evidence for 52% of annotated genes from C. neoformans score - 51 var. grubii. In addition, a large number of novel protein-coding regions, which are not represented in the current C. neoformans var. grubii protein database, were identified. Genome of Cryptococcus, Neuromicrobiology rich in short introns, is being explored as a model to understand evolutionarily conserved mechanisms of splicing. In this study, besides 1. Evaluation of TB kit and cysticercal kit. Investigator: Dr. confirming >3,800 annotated splice junctions, proteogenomics helped Shripad A Patil (Funding by DBT) in identifying several novel splice junctions and revise a number of exon-intron junctions. Similar high-resolution mass spectrometry (a) Anti-cysticercal Antibody Detection Kit: The work is being carried based investigation of proteome of the pathogen under different out in partial collaboration with a veterinary parasitology group at biological and experimental conditions would provide differential Chennai. The cysticercal antigen is prepared from porcine cyst and is protein expression data, which will facilitate better understanding of well characterized. This antigen is used for antibody based diagnosis. protein-level changes associated with pathogenesis. Presently lateral flow system is used and there are plans to use other methods to improve upon the sensitivity and specificity for rapid and 5. Phenotypic identification and molecular characterization accurate immunodiagnosis. of blandm-1 gene in multidrug resistant Gram negative bacilli (b) Anti-mycobacterial Antibody Detection Kit:This work towards isolated from clinical and environmental samples in a tertiary the development of kit for anti-TB antibody in the suspected CSF neuro-care centre. Investigator: Dr. R Ravikumar.
National Institute of Mental Health and Neuro Sciences 175| Annual Report 2014-15
Carbapenemase-producing enterobacteriaceae isolates have been 7. Identification of Mycobacterium tuberculosis antigens of increasingly identified worldwide. Though molecular data regarding diagnostic potential in body fluids using high resolution mass New Delhi metallo-beta-lactamase-1 (NDM-1) producers are spectrometry. Investigators: Dr. R Ravikumar, Dr. Keshav available, data regarding their rate of infection in a hospital setting Prasad (Collaborative project with IOB, Bangalore and SDS and percentage among different clinical isolates are scarce. Hence, TRC and Rajiv Gandhi Institute of Chest Diseases) this study was undertaken to determine the occurrence of blaNDM-1 gene among clinical isolates of multidrug resistant Gram-negative The investigators collected urine, serum and sputum from the TB bacilli (MDRGNB) in a tertiary care centre in Bangalore, Karnataka, suspected patients from the OPD and Laboratory of SDS-TRC & India. A total of 74 MDRGNB isolates were studied. These were RGICD and in-ward patients. screened for MBL production by phenotypic assays such as double disk synergy test (DDST) and Modified Hodge’s test (MHT). The investigators carried out in-depth proteomic analysis of 3+ PCR was performed for the molecular detection of the gene and sputum sample. Initially they processed 2 sputum samples and antibiograms were confirmed by automated bacteriology system. Of performed mass spectrometric analysis. However, they could identify the 74 MDRGNB isolates, 34 were positive for blaNDM-1 gene. All only human proteins and no Mycobacterial proteins. The investigators isolates were resistant to aztreonam and two isolates were resistant to repeated the process with a 3+ sample (O.P. # 188867) by enriching tigecycline. Complete resistance to the tested carbapenems was seen the mycobacterial cells followed by protein isolation and digestion. in 28 (82.35%) of the positive isolates whereas variable carbapenem The enrichment of Mycobacterium cells was carried out by selective resistance was seen in six (17.64%) of the positive clinical isolates. Of lysis of human cells using hypotonic shock. The pellet containing the total 34 PCR positive isolates, 33 (97.05%) NDM-1 producers Mycobacterium cells were washed and used for protein isolation. were identified by DDST and 26 (76.47%) by MHT as producers However, in this sample, though the mycobacterial counts were high of MBL. A high percentage of plasmid encoded NDM was noted in (about 10^7 cells/ml), the protein yield post enrichment was very low. MDRGNB. Phenotypic and molecular screening should be employed Further we repeated the enrichment process again with another 3+ along with routine antimicrobial susceptibility testing to reflect the sample. Mycobacterium cells were enriched by selective lysis of human true number of metallo-beta-lactamase producers. cells using hypotonic shock. The pellet containing Mycobacterium cells were washed and used for protein isolation. In this sample, 6. Development of novel Antimicrobial agents to overcome extensive degradation of proteins with few faint bands was noticed. microbial resistance. Investigators: Dr. R Ravikumar, Dr. Further, the investigators performed in-gel digestion of these proteins Jayanta Haldar (Collaboration with JNCASR, Bangalore) and carried out mass spectrometer analysis. Our analysis resulted in identification of around 50 proteins. Microbial pathogens are widely becoming resistant to the existing drugs and this has turned out to be a major global health problem. A comprehensive analysis of serum samples for Immune complexome The aim of the study is to understand the mechanism of their (IC) from patients confirmed to have tuberculosis infection (2+ or resistance and try developing novel strategy to increase the efficacy of more) has been attempted. The IC’s were enriched by using PEG the existing drug and developing new drugs, to tackle the infectious extraction protocol. The final pellet was washed in PBS buffer and diseases caused by these pathogens. The investigators are working was run in a SDS PAGE. Further the 13 in-gel bands were processed towards the chemical modification of antibiotics such as penicillin, for distaining, reduction, alkylation and digestion. All the fractions vancomycin, aminoglycosides to overcome the inherent resistance of were analyzed using 120 minutes runtime on Orbitrap Fusion Tribrid the parent drugs and achieve enhanced efficacy against drug resistant mass spectrometer interfaced with Proxeon Easy-nLC 1000 system bacteria. The group is also actively involved in developing synthetic (Thermo Scientific, Bremen, Germany). The investigators searched peptidomimetics as therapeutics and addressing the issues (such as the data against combined human and Mycobacterium protein toxicity, location specific delivery, in-vivo activity, and most importantly database resulted in identification of 195 proteins. Though theydid the cost of production) associated with natural antimicrobial peptides. not identify any peptide from Mycobacterium, 15 complement factors and four immunoglobulins were identified. Four complement factors Different classes of antimicrobial agents synthesized in the lab showed were identified to be among the top 10 most abundant proteins. impressive antibacterial activity against different bacteria (both Gram- positive and Gram-negative) including the drug resistant species like 8. Proteomic analysis of chronic and acute meningitis using MRSA and VRE etc. The investigators will test their antibacterial mass spectrometry- based approach. Investigators: Dr. R efficacy against clinical isolates of different bacteria. The antimicrobial Ravikumar, Dr. Keshav Prasad (Collaborative project with agents synthesized in the lab is being analyzed for their in-vitro IOB, Bangalore) antibacterial activity and the ones with impressive results will be tested in-vivo in mice model with a hope of taking the drug to market. 9. Neurobrucellosis-microbiological and clinical evaluation.
176 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Investigators: Dr. Nagarathna S, Dr. Veena Kumari HB 12. Prevalence of prevalence of rickettsial infections in patients (Funding by ICMR) presenting with encephalitis in a tertiary care neurological centre. Investigators: Dr. Nagarathna S, Dr. Veena Kumari Clinical details were collected in a semi-structured proforma from HB, Dr. Netravathi M (Funding by ICMR/DHR) various cases to document the clinical presentations, to determine the incidence of Neurobrucellosis and to compare different laboratory methods for diagnosis of Neurobrucellosis. Cerebrospinal fluid (CSF), Neuropathology blood samples have been collected from all the 472 cases (target sample size).Anti brucellaantidodieshave been analysed for 182 cases 1. Multi-institutional-network programme in molecular neuro- in both CSF and Serum samples using various immunological tests. oncology. Investigator: Dr. Vani Santosh, Dr. Arivazhagan A (Funding by DBT) Control samples have been collected from 100 cases (Infective -50 and non-infective -50) and CSF and serum samples from 50 non- This is a programme consisting of four inter-dependent projects, infective cases have been analysed. which aim to understand the genetic and epigenetic mechanisms in pathogenesis and growth of glioma. Various molecular methods are To determine the seroprevalence of Brucella antibodies in the employed for the same, which are carried out in two clinical centres community and its significance, serum samples have been collected and three labs. A large number of novel molecular findings related to from 60 subjects with occupational risk, 250 subjects with non- pathogenesis and therapy response in GBM have been identified and occupational risk and 100 cases of PUO.For 60 subjects with published. occupational risk, serum samples have been analysed for antibrucella antibodies by Rose Bengal Plate Test (Rbpt), Standard Agglutination 2. Protein aggregate myopathies- A clinical, Pathological, Test (Sat), Enzyme Linked Immunosorbent Assay (Elisa). Out of the immunohistochemical, molecular genetics and proteomic target 250 subjects with non-occupational risk 250, 30 and 90 samples investigation. Investigators: Dr. Gayathri N, Dr. Nalini A have been analysed by RBPT , SAT and ELISA respectively. Out (Funding by DST) of 100 PUO cases blood culture done for all 100 cases. Antibrucella antibodies has been tested for 100, 10 cases by RBPT and SAT Myofibrillar myopathies (MFM) are uncommon, clinically and respectively. genetically heterogenous group of disorders morphologically characterized by myofibrillar structural changes were morphological 10. Confirmation and molecular characterization of hospital- analysed. Twenty cases of MFM diagnosed between 2003-2014 and community-acquired staphylococcus aureus (HA and revealed, two distinct patterns of protein aggregates a) Fibers with CA - MRSA) by polymerase chain reaction. Investigators: multiple internal nuclei and presence of irregular eosinophilic masses, Dr. VeenaKumari, Dr. GS Umamaheswara Rao (Funding by darkly stained on MGT and unstained on oxidative and ATPase (ICMR) stains was noted in 9/20 cases. The masses were intensely labeled to antibodies against ubiquitin, desmin, alpha- B crystalline and myotilin To document the clinical presentations, to determine the incidence in 4/9 cases while, normal labeling was noted in rest of the cases. of MRSA, clinical details were collected in a semi-structured Ultrastructurally, myofilamentous disorganization, streaming and proforma from all the cases. About 600 screening nasal swabs have aggregation of Z band, large irregular electron dense masses, granulo been collected to determine the incidence in the community (target filamentous structures in the subsarcolemmal and intermyofibrillar S aureus-200). To determine the incidence in the hospital set-up, region, myelinic figures and tubule filamentous structures were noted out of 300 target Hospital samples (Clinical -150 and 150-Nasal in all cases. Specimens) 180(134+46) have been analyzed. Processing is being done for a total of 780 cases. Phenotypically, MRSA was confirmed Round to oval globular eosinophilic bodies within rimmed vacuoles using tube coagulase, cefoxitin disc diffusion method, etc. Culture and/or in the sarcoplasm seen in the remaining cases (11/20) appeared positive samples have been preserved for Polymerase Chain Reaction red/green on MGT. M-NBT failed to demonstrate reducing nature (PCR) study which needs to be done. of the bodies. The bodies in two of the cases were seen in angulated basophilic fibers. Vacuoles remained unstained on oxidative enzyme 11. Neuroleptospirosis-study of microbiological and clinical stains, ATPase and Congo red, while positive to acid phosphatase aspects-viral meningitis, is it neuroleptospirosis? and dystrophin. Immunostaining revealed the bodies to be intensely Investigators: Dr. Nagarathna S, Dr. Veena Kumari HB, Dr. stained to desmin, ubiquitin, myotilin and alpha- B crystalline in one Netravathi M (Funding by ICMR) case while, positive to desmin and alpha- B crystalline in four cases,
National Institute of Mental Health and Neuro Sciences 177| Annual Report 2014-15 alpha- B crystalline and myotilin in one case and remained unstained autopsy. Biopsies were taken from three standard sites in the lower in others. Ultrastructurally, myofilamentous disorganization, limb. Cryoprotected samples were stained and examined as per the streaming and aggregation of Z band, multiple small electron dense guidelines of the European Federation of Neurological Societies bodies intermingled with filaments, cytoplasmic bodies with radially (EFNS), using indirect immunoperoxidase with panaxonal marker arranged thin filaments in a few cases and autophagic vacuoles with PGP 9.5 and intreaepidermal nerve fibre density was quantitated on myeloid figures were noted. Identification of mutation serial sections under bright-field microscopy. Analysis of normative data and comparison with published data is in progress. The technique 3. Dysferlinopathies -Biochemical, morphological, and has helped in diagnosis of hereditary sensory autonomic neuropathies proteomic analysis. Investigator: Dr. Gayathri N, Dr. Nalini in children thereby avoiding invasive nerve biopsies in these children A, Dr. MM Srinivas Bharath (Funding by ICMR) with its attendant complications.
4. Mitochondrial respiratory chain disorders: Proteomic 7. Toxoplasma gondii genotypes in cerebral and extra cerebral analysis of Complex I and Complex IV deficiencies. toxoplasmosis. Investigators: Dr. RS Jayshree, Dr. SK Investigators: Dr. Gayathri N, Dr. PS Bindu, Dr. MM Shankar, Dr. Anita Mahadevan (Funding by ICMR) Srinivas Bharath (Funding by ICMR) Recent studies have shown that T.gondii has several genotypes that 5. Studies on the seasonal variation in the ultrastructure are highly diverse: a high frequency of non-archetypes was found of the renal sex segment of the lizard, Mubuyacarinata. in isolates from Brazil and Africa, which were biologically and Investigators: Dr. M Bhagya, Associate Professor, Dept of genetically different from those of North America and Europe. The Zoology, University of Mysore, Dr. BK Chandrasekhar Sagar investigators undertook T.gondii genotyping by multilocus nested (Funding by UGC, New Delhi) PCR RFLP and also sequenced the nested PCR amplicons at 4 loci viz. SAG3, Alt SAG2, BTUB and GRA6. Majority of the cases The information on renal sex segment (RSS) which is an important of CNS toxoplasmosis (22/25) were found to be Atypical Types accessory sexual organ of squamate reptiles is scarce and fragmentary. which may be recombinants of the classical 3 types. The parasite The secretions of the RSS of the male lizard might have a role in DNA from cases of febrile episodes in cancer patients could not the sustenance and maintenance of spermatozoa in the female genital be ascribed to any of the known types by multilocus nested PCR tract. There is a need for understanding the structure and function RFLP and hence are being sequenced. This is the first time that of therenal sex segment and other organs including brain during the parasite has been sequenced from clinical cases of toxoplasmosis breeding and non-breeding seasons in squamate reptiles. The present in India. The investigators envisage that this work is a step further study has been designed to examine ultrastructural seasonal variations which would eventually enable the development of a candidate of the cells and sexual granules, in terms of development, maintenance vaccine of the parasite covering the Indian genotypes as well. This and regression correlated with plasma androgen concentration in the is particularly crucial since vaccines derived from the archetypal lizard Mubuyacarinata. This study will provide comparative data that lineages may not offer protection against non-archetypal genotypes. expand our knowledge of the ultrastructural variation of the RSS in A universal candidate vaccine against the parasite would ideally be male squamates, particularly lizards. The chemical characterization of one which encompasses all the different genotypes of the parasite the RSS secretions will be of great evolutionary significance. seen throughout the world.
6. Establishment of skin punch biopsy for evaluation 8. Development of neuroscience educational material for of peripheral neuropathies. Investigators: Dr. Anita popularizing neuroscience under Human Brain Bank, Mahadevan, Dr. P Satishchandra, Dr. AB Taly, Dr. SK NIMHANS. Investigators: Dr. SK Shankar, Dr. Anita Shankar (Funding by DBT) Mahadevan (ICMR)
The project is a pilot project aiming to establish the technique of skin In keeping with the mandate of developing Neuroscience Educational punch biopsy as a relatively non-invasive technique for diagnosis of Material, a Histological Atlas of the Common Infections of the CNS, small fibre neuropathies. Normative data of intraepidermal nerve fibre along with a set of 48 histological slides, depicting the pathological density was collected from skin biopsies from control at different age features and CD containing the Text and Photographs in the Atlas groups (collected postmortem), patients with neuropathies of varied has been prepared. During the year, nearly 35 histological sets and etiology (hereditary sensory autonomic neuropathy, Guillain Barre more than 50 booklets with CD were distributed among the medical syndrome with autonomic involvement, small fibre neuropathy and colleges and pathology residents. As a policy, the histological slide HIV/AIDS) were collected as per established protocol following sets are provided only to the Medical Colleges teaching post graduate informed consent of patients/close relatives when collected at students of pathology and neurology. In addition, Brain Bank has
178 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 prepared nearly 20 posters (3ft X 3ft) as a public awareness initiative extracellular aggregation could be linked to the amyloid cascade and these are being used regularly in the local exhibitions organized leading to neurodegeneration. by schools and Indian Epilepsy Association. 10. Diagnosis of Alzheimer’s disease using fluorescent probes. Human Brain Museum has been developed in 2400 sqftwell Investigators: Dr. T Govindaraju, Assistant Professor, Bio- illuminated room in the ground floor of Neurobiology Research organic Chemistry Laboratory, JNCASR, Bangalore, Dr. Centre. The place is disabled friendly with a ramp and is free of Anita Mahadevan (Biological human CSF samples with obstacles. The museum has become a center of attraction for school Controls are provided – Pilot Study) and college students and the general public. The activities of the Brain Museum are regularly updated in the Face Book Page “NIMHANS Diagnosis of Alzheimer’s disease is possible only at late stage based on Human Brain Museum”. behavioral tests or cognition in patients while confirmative diagnosis is achieved only by post-mortem examination of brain. Therefore, AB 9. Inflammatory S100A9 protein as a hallmark of traumatic aggregates are attractive target for developing diagnostic molecular brain injury. Investigators: Prof. Ludmilla A. Morozova- probes to monitor progression of the Alzheimer’s disease as well Roche (Department of Medical Biochemistry and as to achieve the early detection of AD. To address this issue the Biophysics, Umeå University, Sweden), Dr. SK Shankar investigators come up with a fluorescent probe to detect amyloid (Biological human tissues- Paraffin blocks of formalin fixed aggregates causing Alzheimer’s disease. The investigators have tissues are provided) performed all in vitro studies showing binding affinity and selectivity of our probe to amyloid aggregates. Further, the investigators would Traumatic brain injury (TBI) is viewed as a risk factor and potentially like to test our probe on cerebral spinal fluid (CSF) samples and brain precursor state for developing neurodegenerative Alzheimer’s and sample of Alzheimer’s patient to locate amyloid plaques in CSF, Parkinson’s diseases. TBI is often accompanied by inflammatory which will be useful in early detection of AD and also in post-mortem processes which can play causative role in triggering the amyloid examination of brain. cascade typical for neurodegenerative diseases. Here we conducted systematic studies on the involvement of inflammatory S100A9 11. Development of the human auditory cortex. Investigators: protein in TBI. S100A9 acts as a pro-inflammatory mediator and its Dr. Soumya Iyengar, Additional Professor and Scientist V, elevated level was found in many inflammatory conditions, including National Brain Research Centre, Gurgaon, Dr. SK Shankar, TBI, inflammation-associated Alzheimer’s disease, cerebral ischemia Dr. Anita Mahadevan (Biological human tissues formalin and others. Recently the abundance of S100A9 mRNA was identified fixed brain provided for study from Human Brain Bank) as a strong feature of aging and a novel mechanism of age-associated inflammation sustained by S100A9 was suggested. The investigators had earlier found that axons in all layers of the auditory cortex were immunoreactive for heavy and medium chain By using immunohistochemistry with a range of antibodies towards neurofilaments by 25 GW and the density of the neurofilament-rich S100A9, amyloid fibrils, oligomers, NeuN, and others the investigators plexus in the cortical wall became adult-like during the first postnatal have explained 19 brain tissues of TBI and controls with the survival year in humans. Although neurofilament-positive axons are found time after the impact from few hours to 10 days. This enabled us throughout the developing auditory cortex, their origins (whether to follow the dynamics of biochemical, cellular and morphological cortico-cortical or thalamocortical) are not known. To answer this changes occurring in post-traumatic tissues. S100A9 was abundantly question, the investigators studied the expression of vesicular glutamate present in all TBI brain tissues. It formed numerous extracellular transporter (type 1 isoform, VGLUT1 and type 2 isoform, VGLUT2) inclusions in a form of plaques, which were not yet of amyloid nature. in the auditory cortex of postmortem human brains at different These plaques reduced in quantity with increasing post-traumatic ages. Earlier studies have shown that VGLUT1 is expressed in the time and nearly completely disappeared after 10 days since trauma, supragranular and infragranular layers primarily in cortico-cortical indicating that efficient clearance mechanisms are working in the synapses whereas VGLUT2 is known to predominate in layers IV and tissues. The investigators have observed abundant presence of S100A9 VI of the cortex and acts as a marker for thalamocortical synapses. The within neuronal and microglial cells, forming intracellular inclusions investigators found that mRNA for both VGLUT1 and VGLUT2 recognized by oligomeric antibodies. Amyloid potential of S100A9 was present in the presumptive human auditory cortex in the second was examined in vitro experiments by using AFM and monitoring trimester and during the postnatal period (1 year - adulthood). Further, its aggregation kinetics by a range of fluorescence dyes such as supragranular and infragranular layers of the developing auditory thioflavin-T, h-FTAA and p-FTAA. The investigators suggest that cortex were immunoreactive for VGLUT-1 whereas Layer IV of the increased intracellular level of S100A9 and its intracellular but not auditory cortex was labeled with VGLUT-2 from 25GW onwards.
National Institute of Mental Health and Neuro Sciences 179| Annual Report 2014-15
12. Role of CNS opportunistic infections in subsequent biomarkers. Ms. Kruthika BS. Guide: Dr. Vani Santosh development of HIV encephalitis. Investigators. Dr. SK Shankar, Dr. P Satishchandra, Dr. Anita Mahadevan Twenty fivebiopsies from GBM patients were collected and (Funding by NIH) histologically characterized into tumor core and periphery. The RNA from all the samples was isolated and purified. The samples having 13. Molecular stratification of adult anaplastic (WHOGrade- a RIN value >6.0 (n=17) was used for Microarray. The raw data was III) lobar gliomas. Dr. Lt. Col KS Rajmohan, PhD – analyzed using R-Bioconductor to identify the differentially regulated Neuropathology. Guides: Dr. Vani Santosh, Dr. Paritosh genes in the tumor core, periphery of the tumor and non-tumor Pandey (Funding by DBT) normal brain samples. The investigators identified 8459, 5826 and 1114 genes to be differentially regulated between Core versus normal, The aim of thestudy is to molecularly stratify adult anaplastic Periphery versus normal and Periphery versus Core respectively, with WHO Grade III lobar gliomas (anaplastic astrocytoma, anaplastic a P value≥0.05 and Fold Change=1.5. On unsupervised hierarchical oligodendroglioma and anaplastic mixed oligoastrocytoma).This clustering, both the core and periphery samples clustered into two study highlights the expression of various molecular markers in AGs different groups showing that they indeed differ with respect to their including their inter-marker correlation and demonstrates their gene expression profile. strong prognostic significance in each of the individual histological subgroups as well as in AGs as a single group. The investigators show that molecular stratification with these markers allows a more objective and robust correlation with survival compared to the current WHO 2007 classification. The investigators propose that, for prognostic evaluation, it is more relevant to classify the AGs based on molecular classifiers. This could be considered as a potential prognostic alternative in future glioma classifications and clinical trials as well as for therapeutic management Finally, through gene expression profiling study, the investigators demonstrate for the first time that 1p19q co-deletion is possibly a true genetic signature in the molecular etio-biology of AOs .
14. Evaluation of EGFR SNPs in glioblastoma and correlation with EGFR gene amplification and expression. Dr. Arvind R, (MPhil - Neurosciences) Guide: Dr. Vani Santosh
SNPs (Single nucleotide polymorphisms) in the EGFR locus have been associated with glioma risk. The EGFR gene variants rs712829 Unsupervised Hierarchical cluster depicting Genes differentially regulated and rs2227983 have shown to be associated with gene overexpression between the core and periphery of Glioblastoma and altered protein activity in various other cancers. In this study on GBM patients, we evaluated the biological relation of these SNPs with EGFR gene amplification, EGFR protein expression, pEGFR expression and prognosis. Neurophysiology
While association of EGFR with rs712829 and pEGFR with 1. Glial Responses in Sporadic Amyotrophic Lateral Sclerosis rs2227983 could not be established, pEGFRimmunopositivity showed (SALS). Investigators: Dr. TR Raju, Dr. Phalguni Anand a trend towards prognostic significance. Furthermore, heterozygous Alladi, Dr. Nalini A, Dr. TN Sathyaprabha, Ms. Pooja Shree status of rs2227983 was associated with shorter overall survival Mishra (Funding by DBT) (p=0.005) and progression free survival (p=0.005) as compared to non-heterozygous individuals.This study shows the heterozygous The microglial responses in sporadic models of ALS were studied. status of an EGFR SNP - rs2227983, emerging as a novel, strong The investigators found downregulation of trophic factors VEGF and peripheral biomarker of poor prognosis in GBM. GDNF, while pro-inflammatory markers PGE-2 and COX-2 were significantly upregulated in microglial cultures exposed to ALS-CSF. 15. Analisis of gene expression profiles in the peritumouralregence Thus the role of glia in exacerbating the disease progression through of glioblastoma and functional charactorization of novel excitotoxicity and neuroinflammation mediated mechanisms is
180 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 strongly indicated. Further investigations on the pathological glial and neuron interactions can lead to better understanding of the disease pathogenesis, and identification of possible therapeutic targets.
Fig. 4: Plot of different study groups i.e. normal control, NALS and ALS against the mean fluorescence intensity for the expression of VEGF (*p<0.5 NALS v/s ALS; $$ p<0.01 NC v/s ALS) and GDNFand ALS against the mean fluorescence intensity for the expression of GDNF ($$p<0.5 NC v/s ALS, *p<0.01 NALS v/s ALS). Test of significance was one way ANOVA followed by Tukey’s post hoc test.
2. Translational research in amyotrophic lateral sclerosis (ALS) - Development of biomarkers for diagnosis, monitoring disease progression and evaluation of toxicity. Investigators: Fig. 1: Representative Confocal micrographs of microglial cultures stained for Dr. TR Raju, Dr. A Nalini, Dr. TN Sathyaprabha, Dr. the COX2 (Green) and PGE2 (Red). Note the upregulation of both the proteins in the cells exposed to ALS-CSF as compared to the Normal controls and NALS. Phalguni Anand Alladi, Dr. MM Srinivas Bharath (Funding by ICMR, New Delhi)
Fig. 2: Plot of different subsets of normal control and ALS against the mean fluorescence intensity for the expression of COX2 (*p<0.5) and PGE2 (*p<0.005). Test of significance was one way ANOVA followed by Tukey’s post hoc test
A) CHIT1 levels in N-CSF and ALS-CSF samples using ELISA, B) CHIT1 level between probable and definite cases within the ALS group, C) CHIT1 level with progression of the disease, D) CHIT enzyme activity between Normal and ALS group, E) CHI3L1 level and F) Osteopontin level between Normal and ALS Fig. 3: Representative Confocal micrographs of microglial cultures group. immunostained for the VEGF (Green) and GDNF (Red). Note the down- regulation of both the proteins in the cells exposed to ALS-CSF as compared Towards the identification of diagnostic biomarkers of ALS, this group to the Normal controls and NALS. of investigators is the only one to have utilized maximum number of
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ALS patient samples till date. The following observations were made: (i) A significantly high Chitotriosidase (CHIT1) level (nearly 20 fold) in the ALS-CSF samples (n=70) compared to normal-CSF (N-CSF; n=38) using ELISA technique (ii) CHIT1 levels in ALS group were further analyzed and the investigators observed a significant twofold increase of CHIT1 level in definite cases compared to probable cases. A significantly high level of CHIT1 at the onset of disease and the level gradually decrease with respect to the progression of disease was also observed. (iii) CHIT enzyme activity was measured in the same population of samples and nearly 16-fold higher enzyme activity in ALS-CSF samples compared to N-CSF samples was observed. Additionally, within the ALS group a similar trend with respect to disease progression was observed; an initial surge of CHIT activity which gradually decreases with progression of the disease. (iv) Beside CHIT1, the investigators also measured the levels of other up regulated proteins in ALS patients. A significant (nearly 1.5 fold) increase in chitinase-3-like protein 1 and osteopontin levels in ALS- CSF compared to N-CSF was observed. Figure 1 shows increase in theta-alpha power with increase in meditation proficiency in all states of Meditation and Rest 3. Neural correlates of mindfulness meditation: A neuro- psycho-physiological and a neuroimaging study. Investigators: Dr. Bindu M Kutty, Dr. John P John, Dr. Seema Mehrotra (Funding by DST-CSI)
This study is also part of PhD Thesis of Dr. Ratna Jyothi Kakumanu, (SRF-DST-CSI) under the title: “Vipassana Meditation and Well- Being: A neuro-Psycho-Physiological Study. In order to understand the neural correlates of Vipassana Meditation, EEG /ERP data was acquired using a Geodesic EEG System 300 (Electrical Geodesics, Inc., USA) with 128 channel Hydrocel sensor net and Net Station software version 4.5.6. A total of 67 Vipassana practitioners with various levels of meditative proficiency; Vipassana Teachers (n=20), Figure 2: Shows an increase in P3 Amplitude that increases with meditative proficiency Senior Meditators (n=23) and Novices (n=24) participated in the study. A game based cognitive paradigm called “ANGEL” designed in the lab of the Institute was used to extract multiple ERPs simultaneously. 4. Efficacy of behavioral strategies of enriched environment and EEG was studied at different mental states including meditation. physical exercises with dietary supplement on establishing a Meditation data of all the groups was preprocessed and analyzed for sustained functional recovery in ventral subicular lesioned the frontal channels (F3, F4) in the theta and low alpha bands. EEG rats. Investigators: Dr. Bindu M Kutty, Dr. Laxmi T Rao data of the cognitive task was analyzed to study P3. All the data was (Funding by DBT) analyzed with EEG lab tool box using Mat-lab scripts. The investigators have demonstrated the efficacy of enriched housing Teachers and Senior Meditators showed significant increase in theta conditions in establishing the functional recovery following ventral (4-8 Hz) and lower alpha (8-10Hz) power in Rest and in most of subicular lesions (VSL). Adult male Wistar rats were used for the study. the meditative states as compared to Novice practitioners. Increase Ventral subiculum was lesioned bilaterally by chemical means which in theta-alpha band has been increasingly recognized as a marker for produced significant impairment in spatial learning performance deeper meditative states and as a marker for efficient cortical tuning. in Morris water Maze tasks. Following one month exposure to Also it is considered to be a measure of enhanced sense of well-being. combination therapy (enriched housing conditions together with The ERP component P3 shows proficiency related graded increase voluntary wheel running and nutritional supplementation), the VSL in amplitude for rare stimuli. Increased P3amplitude indexes better rats showed significant improvement in spatial navigation using cognitive performance. Morris water Maze task. However, the rats reared in standard housing
182 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 conditions could not show such functional recovery. Additionally, Investigators: Dr. TN Sathyaprabha, Dr. Nalini, Dr. TR mPFC dependent functions, such as sustained attention seems to Raju (Funding by Central Council for Yoga & Naturopathy) be preserved in VSL rats. Nevertheless, other parameters such as response latencies, response inhibition etc., should be assessed further Migraine is a highly prevalent neurological disorder that affects to determine if ventral subiculum is involved in various facets of about 13 per cent of the population. Prodromal phase, headache and attentional processes. postdrome phases of migraine are known to impact productivity at work apart from causing cognitive impairment. Therefore, reducing The investigators have also studied the extent of neurogenesis as disability due to migraine assumes priority owing to its long-term enriched housing conditions enhance the neurogenesis and are episodic occurrence. Several non-pharmacological approaches such essential for functional recovery. They have observed that VSL rats as biofeedback and relaxation training, and cervical exercises are exposed to combination therapy as well as rats fed with 18 CW known to significantly reduce frequency and severity of episodes Diet alone also showed significant increase in neurogenesis in the of headaches in these patients. In this study, the investigators have hippocampus. However, VSL rats kept in standard housing could not assessed the efficacy of non-pharmacological approaches such as yoga show such increased hippocamapl neurogenesis. and hydriatic treatments with conventional care in management of patients with migraine. The neurologic and immunogenic mechanism of activation of such interventions will also be assessed.
The investigators have recruited 120 subjects and divided them into four treatment modalities (conventional care, Yoga therapy, hydrotherapy, Yoga with hydrotherapy). It was found that there was modulation of autonomic dysfunction, and reduction of frequency of migraine attack in all groups with statistical significant improvement in subjects with both Yoga and hydrotherapy. Yoga and hydriatic measures can help reduce healthcare/medication costs, improve quality of life and encourage positive health behaviours, aiding better management of migraine.
7. Role of amygdala in the modulation of hippocampal and prefrontal cortical functions in stress: Implications for the treatment of affective disorders. Investigators: Dr. BS Shankaranarayana Rao, Dr. TR Raju, (Funding DBT, Government of India)
Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including cell atrophy and death, which in turn result in memory impairments and behavioral abnormalities. The hippocampus, amygdala and prefrontal cortex are essential components of the neural circuitry mediating stress responses. The hippocampus and medial prefrontal cortex, which provides negative feedback regulation of the stress response, are particularly Photomicrograph depicting the Di-amino Benzedine (DAB) stained neurons vulnerable to degenerative changes caused by chronic stress. In expressing doublecortin (marker for immature neurons) immuno-reactive cells in the subgranular layer of dentate gyrus. contrast, amygdala which positively regulates hypothalamo-pituitary- adrenal axis undergoes hypertrophy after stress. Several studies have demonstrated that the amygdala is critically involved in mediating 5. Evaluation of sleep architecture and EEG dynamics in long- stress-induced affective behaviors and modulating hippocampal term and short-term practitioners of Vipassana Meditation. function. Thus, the project was focused on evaluating the role of Investigators: Dr. Bindu M Kutty, Dr. TR Raju (Funding by amygdala in mediating/modulating stress effects on hippocampal and ICMR) prefrontal cortical functions. This was achieved by either permanently or temporarily inactivating the basolateral amygdala during stress. 6. Effect of yoga and hydriatic application in migraine – A The results show that both permanent inactivation of amygdala clinical, electrophysiological and immunological study. and the temporary inactivation could prevent chronic stress induced
National Institute of Mental Health and Neuro Sciences 183| Annual Report 2014-15 dendritic atrophy and volumetric alterations in the hippocampus. resulted in abnormal hippocampal synaptic plasticity. Also, depressed Further, it was also observed that the amygdala inactivation could also rats showed hypotrophy of dentate gyrus and amygdalar hypertrophy. prevent stress induced spatial memory and decreased hippocampal Enriched environment rescued hippocampal synaptic plasticity, synaptic plasticity. The results show that modulating amygdala can be restored dentate gyrus hypotrophy and amygdalar hypertrophy. a potential tool in treating stress induced cognitive deficits.
Chronic enriched environment restores impaired hippocampal long-term Prevention of stress-induced impaired learning and memory by inactivation potentiation in depressed animals. Depressed animals showed decreased of basoloateral amygdala during stress. Number of sessions to reach 80% long-term potentiation (LTP) when compared with normal animals after high correct choice (A) and the number of errors in the retention test (B) in T-maze frequency stimulation (HFS) and this deficit was restored by chronic exposure rewarded alternation task. Stress-induced working memory impairment and to enriched environment. NC = Normal control (n = 10), DEP = Depression (n = retention memory errors were blocked by inactivation of BLA. Data expressed 10), SA = Saline administered (neonatal) (n = 8), DEP + 6h EE = Depressed rats as Mean ± SEM. NC= Normal control (n=15), ST= Rats subjected to 10 days exposed to 6h of EE for 14 days (n = 8), 6h EE per se = Normal rats exposed to of immobilisation of stress (n=15), LI+ST= Lidocaine inactivation + stress 6h of EE for 14 days (n = 8). Data expressed as Mean ± SEM. One-way ANOVA (n=15), VC (SAL) +ST= Vehicle control (0.9% saline) + stress (n=15) and SC Followed by Tukey’s post hoc test, ***p < 0.001 vs. NC and ###p<0.001 vs. DEP. (LI)= sham control (n=15). One-way ANOVA followed by Tukey’s post hoc test. ***p<0.001, **p<0.01, *p<0.05 vs. NC; $$p<0.01, $p<0.05, vs. ST.
8. Cellular and molecular basis of endogenous depression induced cognitive deficits. Investigators: Dr. BS Shankaranarayana Rao, Dr. TR Raju (Funding by DBT)
Depression is the most prevalent forms of chronic mental illness. Current treatments for depression are inadequate and progress in understanding the neurobiology of depression is slow. Depression Restoration of depression-induced atrophy of dentate gyrus (A) and hypertrophy of amygdala (B) by enriched environment. NC = Normal control is known to cause several deficits including cognitive impairments. (n = 5), DEP = Depression (n = 5), SA = Saline administered (neonatal) (n = 5), Several clinical studies have demonstrated that chronic depression DEP + 6h EE = Depressed rats exposed to 6h of EE for 14 days (n = 5), 6h EE has many deleterious effects on hippocampal, cortical and amygdalar per se = Normal rats exposed to 6h of EE for 14 days (n = 6). Data expressed as Mean ± SEM. One-way ANOVA Followed by Tukey’s post hoc test, ***p < structure and function that leads to learning and memory deficits. 0.001 vs. NC and ###p<0.001 vs. DEP. Although there are structural and functional evidences from human studies indicating cognitive dysfunction in depression, none of 9. Evaluation of antiepileptic activity of medicinal plants the studies have examined the neural basis of cognitive deficits in in animal models of epilepsy. Investigators: Dr. BS depression. Studying cognitive deficits in animal models often helps Shankaranarayana Rao, Dr. Sadhana S, ICT, Mumbai to discern the cellular and molecular pathologies underlying the (Funding by DST) disease and develop suitable therapeutic strategies. Accordingly, in the proposed study, the investigators are planning to evaluate the Epilepsy is the most common neurological disorder and even multi- effects of newer antidepressants escitalopram, reboxetine treatment drug therapy is not effective and neurosurgical procedures may be and enriched enrichment on depression-induced cognitive deficits indispensable. The current therapeutic treatment of epilepsy with comprehensively at multiple level of neural organization namely, modern antiepileptic drugs (AEDs) is associated with several side- morphological, biochemical, electrophysiological, molecular and effects. Drugs also have low therapeutic window so it need continuous behavioral levels. Also, the current study will explore effect of therapeutic drug monitoring and approximately 30 per cent of antidepressant treatment and exposure to enriched environment on the patients continue to have seizures with current AEDs therapy. cognitive functions in depressive condition. Endogenous depression Further, a large number of drug interactions seen with almost all
184 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 current antiepileptic drugs make it more difficult to attain easy control in REM stage and total sleep period also increased. MS rats showed on seizures. Traditional systems of medicine have been exploring fear generalization with increased fear memory retention than number of medicinal plants as an effective treatment of epilepsy over normal control (NC). The findings of the study suggest that stress the past centuries but so far have not got the place among the standard during SHRP has sensitized the hippocampus-amygdala-cortical anticonvulsant medication because their efficacy has not been loops which could be due to increased release of corticosterone that established. Thus, research for finding new drugs with less adverse generally occurs during REM sleep. These rats when subjected to effects and more efficacy, seems to be essential. Accordingly, the study fear conditioning exhibit increased fear memory and increased fear focuses on the evaluation of antiepileptic potential of medicinal plants generalization. The development of helplessness, anxiety and sleep to find out the mechanism of action for its antiepileptic activity along changes in human patients, thus, could be related to the reduced with possible active constituents responsible for the same. Extractions thermal, tactile and social stimulation during SHRP on brain plasticity of plants Eclipta alba and Pistacia integerrima was used for evaluation and fear memory functions. of antiepileptic activity and also in combination with standard antiepileptic therapy. Further evaluation of effect of particular fraction of the extract for effects of synaptic plasticity in the hippocampus is being studied. It has been observed that temporal lobe epilepsy is associated with decreased hippocampal synaptic plasticity and the same was partially restored by chronic treatment of Eclipta alba and Pistacia integerrim. The effect of active components of both these plant extracts on spontaneous recurrent seizures is being studied.
10. Maternal separation anxiety and fear learning/memory: effects on sleep architecture in adulthood. Investigators: Dr. Laxmi T Rao, Dr. Bindu M. Kutty (Funding by CSIR, New Delhi) Figure 2.Freezing to specific and non-specific stimulus after 24hours of classical fear conditioning. Mean change in freezing behavior to the pre-tone, CS- and CS+ from NC (n=10) and MS (n=18) rats. The spontaneous recovery with reduced freezing after receiving two CS+ was seen in NC, but similar recovery was not observed in MS rats. Data represented are Mean ± SEM. *P<0.04; **p<0.01; ***p<0.003 are in comparisons to NC; ##p<0.01; #p<0.05 compared with pre-tone conditions following Tukey’s multiple comparison test. NC, Normal Control; MS, Maternal Separation Stressed group.
11. A multimodal approach to evaluate the efficacy of enriched environment in ameliorating early maternal separation induced changes in brain function: A morphological, biochemical and behavioural study in rats. Investigators: Dr. Laxmi T Rao, Dr. Bindhu OS, Jain University, Bangalore Figure 1.The effect of MS on sleep architecture. (a) MS during SHRP had significant impact on sleep showing significant (a) reduction in quiet wake (Funding by ICMR, New Delhi) (W2) and increase in REM sleep period; (b) reduced total wake time (TWT) and increased total sleep time (TST). Data represented are mean + SEM from 12. Effect of Celestrus paniculatus on cognitive deficits in NC (n=6) and MS (n=8) rats **P<0.001; *P<0.01 chronically stressed rats: A behavioral, neurochemical, Rapid Eye Movement (REM) sleep plays an important role in structural and electrophysiological approach. Investigators: integrating new information with the previously stored emotional Dr. Bhagya V, Dr. BS Shankaranarayana Rao (Funding by experience. Hence, the impact of early maternal separation and DST) isolation stress (MS) during the stress hyporesponsive period (SHRP) on fear memory retention and sleep in rats were studied. The neonatal Severe, traumatic stress or repeated exposure to stress can result in rats were subjected to maternal separation and isolation stress during long-term deleterious effects, including hippocampal cell atrophy and postnatal days 5-7 (6h daily/3d). Polysomnographic recordings and death, which in turn result in memory impairments. Chronic stress is differential fear conditioning was carried out in two different sets of known to precipitate several affective disorders including depression, rats aged two months. The neuronal replay during REM sleep was post traumatic disorder and anxiety. Drugs of natural origin are known analyzed using different parameters. MS rats showed increased time to possess effects on the central nervous system and are emerging
National Institute of Mental Health and Neuro Sciences 185| Annual Report 2014-15 as promising alternative therapies in the treatment of psychiatric disorders. Accordingly, the aim of the present study was to evaluate the effect of Celastrus paniculatus oil treatment on stress-induced anxiety- like behavior, spatial learning and memory impairment, changes in acetylcholinesterase (AChE) activity and synaptic plasticity in the hippocampus. Male Wistar rats were subjected to restraint stress for 21 days (6h/day). Stressed rats were treated with Celastrus paniculatus for 14 days. The investigators observed that chronic restraint stress resulted in enhanced anxiety behavior, impaired working memory in T-maze task. Interestingly, Celastrus paniculatus treatment showed anxiolytic activity (Figure 1) and ameliorated stress-induced working memory impairment (Figure 2) in T-maze. Thus, the study indicates that Celastrus paniculatus is a potential natural drug for the treatment of stress-induced cognitive deficits.
Chronic stress increased anxiety-like behavior in elevated plus maze (EPM) was decresed by chronic treatment with Celastrus paniculatus. Percent time Depression-induced atrophy of dentate gyrus (A) could be restored by one spent in open (A) and closed (B) arms of EPM. Data is represented as mean hour exposure to enriched environment with reboxetine treatment but ± S.E.M. NC: normal control. ST: rats subjected to restraint stress for 21 days amygdalar hypertrophy (C) of was not restored by either of the treatments. (6h/day). ST+ VE, ST + CP-400 and ST + CP-600: stressed rats subjected to 14 Depression has not altered the total volumes of the hippocampus (B). Data days of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, i.p., expressed as Mean ± SEM. One-way ANOVA followed by Tukey’s post hoc test ### respectively. One-way ANOVA followed by Tukey’s post-hoc test. ***p<0.001 (F4, 29 = 10.47, p<0.0001), **p<0.01 vs. NC, p<0.001 vs. DEP. NC = Normal Normal vs stress. $$p<0.01, $$$p<0.001 stress vs stress + drug treatment. control (n= 6), DEP = Depressed (n = 8), SA = Saline administered (neonatal) (n = 8), DEP + 1h EE = Depressed rats subjected to 1h of EE for 14 days (n = 5), DEP + 1h EE + RB = Depressed rats exposed to 1h EE for 14 days and treated with 2.5mg/kg reboxetine (n = 7).
Major depression is a psychiatric disorder associated with severe morbidity, poor quality of life and mortality. Depression affects the structural integrity of the prefrontal cortex, hippocampus and the amygdala. In addition to structural deficits, depression also induces severe cognitive impairments. Depression severely impairs neuronal plasticity, which is a set of processes that helps a network of neurons Amelioration of stress-induced impaired spatial working memory in T-maze task by Celastrus paniculatus treatment. The number of days to reach 80% to change the strength and form of their connectivity to adapt to a correct choice was higher in stressed animals and the same was restored to challenge posed by an organism’s environment. There is a wealth normal by cellustrus treatment. Data is represented as mean ± S.E.M. NC: of evidence to indicate that major depression is associated with normal control. ST: rats subjected to restraint stress for 21 days (6h/day). ST+ VE, ST + CP-400 and ST + CP-600: stressed rats subjected to 14 days dendritic loss, decreased neurogenesis and long-term potentiation of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, i.p., (LTP). Also, studies from the lab of the Institute have shown that respectively. One-way ANOVA followed by Tukey’s post-hoc test. *p<0.05, LTP is abolished in an animal model of depression and depressed **p<0.01 Normal vs stress, $p<0.05, $$p<0.01 stress vs stress + drug treatment. rats did not display increased potentiation in response to electrical stimulation of the Schaffer collateral pathway. Depression has been 13. Cellular, molecular and electrophysiological basis of treated with antidepressant drugs and are the most widely prescribed depression-induced cognitive deficits. Investigators: Dr. therapy for depression. However, antidepressant drugs have a severe Mahati Krishna, Dr. BS Shankaranarayana Rao (Funding by side effect profile that includes irregular heart rhythms, decreased sex CSIR Research Associateship) drive, loss of libido, thymoanaesthesia, nausea, weight gain, daytime
186 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 sleepiness and/or insomnia which causes some patients to discontinue 15. Evaluation of age-related synaptic changes in human antidepressant treatment. Accordingly, in the current study, the substantia nigra pars compacta. Investigators: Ms. Jyothi investigators have endeavoured to address depression and associated HJ, Dr. Phalguni Anand Alladi, Dr. TR Raju (Funding by cognitive deficits using novel treatment modalities in an adult model ICMR) of endogenous depression. Behavioural, morphological, biochemical, molecular and electrophysiological parameters are being investigated The investigators established, for the first time, Golgi staining protocol to dissect various attributes of depression-induced cognitive deficits. for formalin fixed archived human tissues to study the effect of aging The main issue the investigators have tried to address in the study on dendritic arborisation in human substantia nigra. It was found that is to develop strategies to treat depression and associated cognitive most of the neurons of the SNpc were pleomorphic. Few neurons had deficits by increasing neural plasticity in the brain. The aim was to triangular cell body (Figure 1). The dendritic pattern suggests that use non-pharmacological treatment regimens such as environmental most of the cells were multipolar and showed dendritic branching. enrichment (EE) in the endogenous model of depression. Few cells were spindle shaped with few dendrites. The diameter of the neurons ranged from 23-43 µm, with an average cellular diameter of 14. Combined effect of dietary Genestein and CIMT on 30.76 µm. Few more samples are being analyzed to deduce the effect modulation of synaptic plasticity in intracortical ischemic of aging. stroke. Investigators: Dr. Sabitha K Rajesh, Dr. Laxmi T Rao (ICMR, New Delhi)
The investigators are studying the effect of Genestein and Constrained induced movement therapy in modulating the neurological deficits and neuronal plasticity in motor cortex by Endothelin-1 induced intracortical ischemic stroke model of rat. For this, standardized ET-1 rat model of focal ischemia was standardized in conscious rats. Stroke was confirmed by TTC staining. Neurological deficits were evaluated by various behavioral paradigms like gait, cylinder, ladder test and reach to grasp task. Rats pretreated with genestein and subjected to CIMT post stroke showed significant improvement in the use of impaired forelimb.
Figure 1: Representative tracings of the Golgi stained neurons from different sub-regions i.e. medial (A), intermediate (B) and ventrolateral (C) aspect of A. Cylinder test Data shows the % use of uneffected limb(ipsilateral) in NC, IS the human substantia nigra pars compacta to study the dendritic arborization. and GEN+IS .Data represented as Mean ± SEM from (n=8).* p<0.01 indicate Scale bar= 100µm. significant comparisons across NC,IS , GEN+IS and IS+GEN+CIMT using 1 way ANOVA followed byTukey’s Multiple Comparison Test , *p<0.01 Table 1: Size of the Golgi stained neuronal cell bodies (n=25): Diameter Cell body- Size Perimeter (µm) Area(µm²) (µm) Range 104.5- 204.3 646.7- 1209.6 23.1-43.3 Average 140.6 860.1 30.8
16. Evaluation of developmental apoptosis and nigral neuronal response in two mice strains with differential sensitivity to 1-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine (MPTP) B. Reach to grasp task Data represented as Mean ± SEM from NC (n=9) and their crossbreds. Investigators: Ms. Jyothi HJ, Dr. ,Saline(n=3), Vehicle Control(n=3), IS (n=8) CIMT(n=3) , IS +GEN(n=8)and Phalguni Anand Alladi, Dr. TR Raju (Funding by Science IS+Gen+CIMT(n=3) ; One way Anova followed byTukey’s Multiple Comparison Test ***p,0.001,*p<0.01 and Engineering Research Board, DST, India)
National Institute of Mental Health and Neuro Sciences 187| Annual Report 2014-15
This study aims at unraveling the mechanisms for ethnicity based strains with markedly differing vulnerability to neurotoxin MPTP. differences in prevalence of Parkinson’s disease using mice models. The vulnerable strain C57Bl/6 has fewer nigral neurons than the Expression of proteins like Tyrosine hydroxylase, Bax, Bcl-2 and resistant CD1 mice. They propose to examine the differences Caspase-3 was studied in the substantia nigra of the P14, P22 and in the number of glia and glia-mediated neuroinflammation in adult groups using Immunohistochemistry. Nigral neuronal numbers these mice strains, which may be responsible in amending the were counted using stereology. Protein expression was assessed using vulnerability to the neurotoxin. densitometry and immunoblotting. Morphometry was performed to measure the size of dopaminergic neurons. Apoptotic dopaminergic 18. Isolation and characterization of toxic factor(s) present neurons were identified using TUNEL assay. Preliminary results in CSF of patients suffering from Amyotrophic Lateral indicate that the crossbreds are phenotypically identical to the resilient Sclerosis. Ms. Anu Mary Varghese. Guides: Dr. TR Raju, CD-1. MPTP induced toxicity and mRNA levels are being evaluated. Dr. MM Srinivas Bharath, Dr. Nalini A (Funding by CSIR Senior Research Fellow)
Quantitative proteomics followed by ELISA revealed >15 fold increase of Chitotriosidase (CHIT) in ALS-CSF compared to controls. In view of these finding, this project aimed to study the effect of CHIT on glia and neurons in the in vivo model of sporadic ALS. Intrathecal administration of CHIT to neonatal rats, increased number of Iba1 positive microglial cells and astrocytosis in both white and grey matter of the ventral horn of spinal cord. It also reduced the number of ChAT positive motor neuronal cells. The studies suggest CHIT can induce glial activation, resulting in neuroinflammation, which accentuates degeneration of motor neurons.
Figure 1: Immunohistochemical staining of Bax and Bcl-2 co-labeled with TH at postnatal 22 day in C57Bl/6, CD1 and F1X1 mice. Both the proapoptotic Bax and antiapoptotic Bcl-2 protein expression was significantly higher in C57BL/6 as compared to CD1 or F1X1 at P22. The ratio of Bax:Bcl-2 which decides the fate of the cells survive or undergo apoptotis is still significantly high in C57BL/6, which may be the determining factor for enhanced apoptosis in thesusceptible strains. Fig 1: Effect of in vivo administration of CHIT in glia. (A) Representative confocal micrographs (merged) of spinal cord sections co-labeled with Iba1 17. The role of glia in aging and in determining neurotoxicity of (green) and GFAP (red) in CHIT injected, Normal control (NC) and positive control, ALS. Note increase in Iba1 labeled microglia on CHIT administration 1-Methyl-4-Phenyl-1, 2,3,6-Tetrahydropyridine (MPTP). (mainly in C100) and ALS group. An increase in GFAP expression was also Investigators: Dr. Phalguni Anand Alladi, Dr. TR Raju, Dr. observed in CHIT and ALS-CSF injected group. Bindu M. Kutty (Funding by DBT) Histogram representing enhanced expression of GFAP in ventral horn white matter in CHIT injected group compared to buffer and normal controls in terms of (B) intensity (**p <0.01 C50, C100, C200 vs. NC; ***p <0.001 C500, Monoamine oxidase inhibitors are the earliest drugs of choice ALS vs. NC and $$p<0.01 C50, C100, C200 vs. Buffer; $$$p < 0.001 C500 and ALS vs. Buffer) and (C) area (*p <0.05 C50 vs. NC; **p <0.01 C100, C200, C500, in Parkinson’s disease (PD), which target the glial monoamine ALS vs. NC and $$p < 0.01 NC vs. C50, C100, C200, C500 and ALS). (D) CHIT oxidase enzyme B. The glial origin of MAO-B suggests a induces a significant up-regulation of Iba1 positive microglial cells at a dose modulatory role for glia. The role of glia in disease pathology is of 100 pg similar to ALS-CSF compared to buffer and normal control (*p <0.05 C100 & ALS vs. NC; $p < 0.05 C500 and ALS vs. Buffer). not well understood. Here the investigators plan to study two mice
188 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
ii. Confocal photomicrograph showing Human Embryonic Stem Cells expressing OCT4
Fig 2: Effect of CHIT on motor neurons and axonal density. (A)Representative confocal images (merged) of spinal cord section co-labeled ChAT (green) and SMI-31 (red) in Control (buffer), CHIT (C50, 100, 200, 500 pg) and ALS-CSF injected groups. Note the decrease in the number of ChAT immunoreactive neurons in C500 and ALS-CSF group. Scale bar = 150 μm (for all images). (B) CHIT induces loss of ChAT positive motor neuronal cells, similar to ALS-CSF, at a dose of 500 pg. (**p <0.01 C500 vs. NC; ***p <0.001 ALS vs. NC; $$ p < 0.01 C500 & ALS vs. buffer). (C) Histogram representing area of phosphorylated neurofilaments (SMI-31) in white matter of ventral horn of spinal cord.
iii. Phase Contrast photomicrograph showing Neural Stem Cells on Day10 of 19. Directed differentiation of human embryonic stem cells into differentiation motor neurons, their characterization and use as a cellular model for sporadic amyotrophic lateral sclerosis. Ms. R. Sumitha. Guides: Dr.TR Raju, Dr. TN Sathyaprabha, Dr. A Nalini (Funding by ICMR Senior Research Fellow)
The aim of this study is to differentiate Human Embryonic Stem Cells BJNhem20 into spinal motor neurons, characterize them and as a cellular model for sporadic ALS. BJNhem20 was obtained from JNCASR and the cell line was established in Cell Culture/Stem Cell biology laboratory, NRC, NIMHANS. The stem cells were grown on mitotically inactivated mouse embryonic fibroblast feeder layers. Retinoic acid and purmorphamine were used for motor neuron derivation. During differentiation phase contrast and confocal images iv. Confocal photomicrograph showing Neural Stem Cells expressing Nestin were taken. The standardized protocol will be followed and the and GFAP cells will be used for quantitative PCR, immunocytochemistry and electrophysiology.
Results of Standardization experiments:
v. Confocal photomicrograph showing Immature Neurons expressing βIII i. Phase Contrast photomicrograph showing HESCs (40x) and Embryoid bodies (4x) tubulin and Olig2
National Institute of Mental Health and Neuro Sciences 189| Annual Report 2014-15
group compared to the control groups. In addition, VEGF expression was analyzed by immunohistochemistry. Quantification of the same is in progress.
vi. Phase contrast photomicrograph showing Neurons with processes on Day 32 of differentiation.
Fig 2: The graphs show the quantified results of BDNF and IGF-1 immunostaining. There is significantly increased expression of BDNF in ALS- 20. Pathophysiology of skeletal muscle in amyotrophic lateral CSF group as compared to NC, Sc and NALS-CSF groups (*p<0.05NC, NALS, sclerosis (ALS)- An experimental study in a rat model. SC v/s ALS. The IGF-1 expression is reduced in ALS-CSF group though not Ms. Shruthi S. Guides: Dr. TR Raju, Dr. Gayathri N, Dr. significantly. Phalguni Anand Alladi, Dr. Nalini A. (Funding by CSIR Senior Research Fellow)
Fig 3: Representative Confocal micrographs of skeletal muscle stained for the VEGF. Note the upregulation of VEGF in the ALS-CSF group as compared to the Normal controls, shown qualitavely.
21. Examination of aberrant neural synchrony in schizophrenia – A multi-modal EEG, fMRI and polysomnography study. Mr. Arun. Guides: Dr. Bindu M Kutty, Dr. John P John (Funding by ICMR Senior Research Fellowship)
The above study is an effort to find a correlation between EEG and fMRI parameters of cognitive functions, and sleep EEG parameters in schizophrenia patients, minimally exposed to anti- Fig 1: Representative Confocal micrographs of cultures stained for theα- psychotic medications. The cognitive function being assessed include bungarotoxin(Green) and NF-200kd (Red). Note the innervated pattern in a component of visual ‘gestalt perception’ and auditory ‘corollary normal control and denervated and reinnervated NMJs in ALS-CSF group where neurofilament fails to extend to the NMJ. discharge mechanism’. Sleep study has been carried out in 55 schizophrenia patients and 49 controls, so far. Of these, ERP study was done in 23 schizophrenia patients and 23 controls. fMRI study To investigate the ALS-CSF (Amyotrophic Lateral Sclerosis- was done in 13 schizophrenia patients and 16 controls. The following Cerebrospinal Fluid) induced changes in the skeletal muscle in rat table depicts some of the preliminary results from fMRI connectivity pups, rat pups were intrathecally injected with ALS-CSF on 3rd, 9th data of 16 controls and 12 schizophrenia patients. The patient group and 14th day, and sacrificed on 16th day. Pathological changes in the clearly has lower task-induced connectivity in the right cingulo- form of NMJ disintegration was evident in the neuromuscular junction opercular network during prediction error tasks (simultaneous Gestalt by α-bungaratoxin staining co-labeled with neurofilament 200kd perception and Corollary discharge), than age-matched control marker in the extensor digitorum longus. Further, the investigators subjects (Fig. 1). This is consistent with the aberrant neural synchrony quantified the IGF and BDNF expression which was altered in ALS hypothesis of schizophrenia.
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70 Rajayoga practitioners and fMRI acquisitions for a subset of them have been completed. Long-term Rajayoga practitioners show larger differences in cognitive processing as compared to short term practitioners indicating trait changes due to neuroplasticity caused by long term mental training.
23. Behavioral validation of cognitive dysfunctions in a rat model of schizophrenia. Ms. Neethi Prem. Guides: Dr. Bindu M Kutty, Dr. Laxmi T Rao, Dr. John P John
In order to study neural circuitry abnormalities in limbic lobe circuitry Figure 1:Functional connectivity difference at region of interest level (ROI- in schizophrenia, Benes FM and colleagues developed a ‘partial’ ROI) between healthy controls and patients with schizophrenia during gestalt rodent model, where GABA receptor antagonist, picrotoxin, is perception and corollary discharge tasks combined.(A) Connectivity ring A showing the seed ROI (right central opercular cortex) and its connected ROIs, stereotaxically infused into BLA. This induces a reduction in the that were significantly reduced in patients with schizophrenia (shown as blue number of GABA cells in sectors CA3/2 but not CA1, pattern that is points and lines). These were obtained by substracting ROI-ROI connectivity measures between 136 standard ROIs (representing whole brain) of controls remarkably similar to that seen in schizophrenia. from that of patients during the task. The intensity of line colour indicates the strength of connectivity difference. (B) List of brain regions showing reduced Implication of these change towards pathophysiology of schizophrenia connectivity to right central opercular cortex seed area, as depicted in (A). (C) Effect size measures (arbitrary units) across this network for each subject. was assessed using following tests: Hyper-dopaminergic activity, Note the lower values among the patients (highlighted by red square). The social withdrawal, sensorimotor gating and cognitive function deficits statistical values were thresholded using a combination of connection-level were assessed in open field test (OFT), social interaction test (SIT), thresholds (false discovery rate (FDR) estimations with the level of significance set a priori at p<0.05) and network-level thresholds (network-based statistics prepulse inhibition (PPI) and water maze, respectively. using permutation tests in conjunction with FDR corrections set at p<0.05), both two-sided. CNT-controls; SCZ-schizophrenia.
22. Neural correlates of wellbeing in long term Rajayoga practitioners - A multimodal study. Mr. Ajay Kumar Nair. Guides: Dr. Bindu M Kutty, Dr. John P John, Dr. Seema Mehrotra
Fig 2: A) Distance travelled in cm and B) Velocity in cm/sec2. One-way ANOVA with post hoc tukey’s test did not yielded significant difference between the groups (NC, n=10; P-Veh, n=10 and Picro, n=10). Bar represents Mean ±SEM.
The P300 is a positive going ERP seen in central and parietal electrodes that is used to assess cognitive performance. Long-term Rajayoga practitioners show a larger difference between the response generated for the rare and stimuli as compared to short-term Rajayoga practitioners. ERN or Error Related Negativity is negative going ERP seen frontocentrally and is an indicator of conflict processing. Long-term Rajayoga practitioners show a larger difference between incorrect and correct responses as compared to short-term Rajayoga practitioners. Fig 3: Session I: Social affiliation and sociability. Mean length of time (±SEM) in the chamber with the stranger (“Stranger 1 – S1”) compared to the opposite Meditation and spiritual practices are known to enhance well-being. chamber (“Empty Chamber - E”) and Home Chamber (HC). Typically, normal control animal will spend significantly more time in the chamber with Stranger However, the underlying neural correlates and processes are not 1 compared to the chamber with empty cup, indicating normal sociability, well understood. The study uses Psychological assessments, EEG, social motivation and affiliation. Unlike NC and P-Veh group, Picro animals ERP and fMRI for correlating well-being in long term Rajayoga failed to demonstrate a preference for social proximity. [n: NC – 10, P-Veh – 10, PICRO – 10). For NC, ***(S1 vs. E; P < 0.001) and **(S1 vs. HC; P < 0.01) practitioners (Brahma Kumaris tradition). Aquisition of high density and P-Veh, **(S1 vs. E; P < 0.01) by ANOVA with repeated measures followed EEG, ERP recordings and psychological assessment data from over by Post-hoc tukey’s test.
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Table 1: The time (seconds) spent in each quadrant during the probe trial when platform was removed Groups NC P-Veh Picro Northeast (Target) 26.09 ± 4.549 27.26 ± 2.485 16.6 ± 3.856 Northwest 11 ± 1.817 14.33 ± 2.621 10.95 ± 2.311 Southwest 8.754 ± 2.562 4.862 ± 1.584 14.15 ± 2.752 Southeast 14.15 ± 0.5486 13.55 ± 3.047 18.3 ± 1.013
Please note that the NC, P-Veh groups spent more time in the platform quadrant when compared to the other quadrants while the Picro group did not show the same trend. *(P-Veh vs. Picro; P < 0.05) by ANOVA with repeated measures followed by Post-hoc tukey’s test. Fig 4: Session II: Social memory and novelty. Mean length of time (±SEM) in Impairment in Picro group was seen in social interaction test, while spared the chamber with the stranger (“stranger 1 – S1”) compared to the opposite in other tests such as open field test, prepulse inhibition. Although the chamber (“stranger 2 – S2”) and Home Chamber (HC). NC group shows control groups performed better in Morris water maze during training when statistically significant preference for social novelty by spending more time compared to Picro group, it is not statistically significant. in chamber with the S2. Although P-Veh group does not show statistically significance, similar trend as seen in NC is observed. However, rats in Picro group failed to demonstrate a preference for social novelty by spending same 24. Modulation of neuronal cytokines (IL-2, TNF-A) and amount time in all chambers. [n: NC – 10, P-Veh – 10, PICRO – 10). For NC, cytokine receptor expression due to Benzo [a] Pyrene **(S2 vs. S1; P < 0.01) and **(S2 vs. HC; P < 0.01) by ANOVA with repeated Exposure in rat brain. Ms. Rajeshwari Parida. Guides: measures followed by Post-hoc tukey’s test. Dr.TN Sathyaprabha, Dr. Vijay Kumar Kalia
This study aims at the cytokine and their receptor expression in the tumor induced cells and tissues. Currently, work on the human U87 glioma cell lines is in progress. These cells are treated with clinically approved drugs such as Temozlomide and 2-Deoxy-D-Glucose and their combinations at various concentrations. Later, TNF-alpha and IL-2 expression was checked. Receptors for each of these cytokines were also checked. Results show that IL-2 expression was high in the cells treated with combination drugs. IL-2 is anti-cancer cytokine and used for therapeutic approach. It will be interesting to see which Fig 5: Averaged PPI data of 10 rats in each group – NC, P-Veh and Picro is signaling pathway is taken up by this cytokine. shown. The 10 startle alone trials of block II are averaged for each rat and the averages of the other trial types expressed as the percentage of the stimulus alone startle amplitudes. The figure shows the startle response amplitudes 25. A study to identify an early diagnostic marker for diabetic under different prepulse conditions. Three different prepulse intensities peripheral ne uropathy. Ms. Anu. P. John. Guides: Dr. T.N. (73, 76 and 82 dB) were measured. No significant difference was observed between groups for different types of prepulse intensities (73, 76 and 82 dB). Sathyaprabha, Dr. Anita Mahadevan, Dr. R. Anil Kumar Data is represented as Mean ±SEM Patients with diabetes, prediabetes and diabetic neuropathy are being recruited from the out-patient departments of Karnataka Institute of Diabetology and NIMHANS. The association between autonomic functions, nerve conduction velocity variations, small fibre density changes and biochemical parameters for oxidative stress (Gamma glutamyl transferase) and apoptosis (Serum sFas) will be ascertained in the four different groups (diabetics, prediabetics, diabetics with DPN and age matched healthy volunteers). The collected data will be entered into Microsoft excel work sheet. The data will be expressed using descriptive statistics such as mean, standard deviation for continuous variables; frequency and percentages for categorical Fig. 6: Performance of rats in the Morris water maze task. Graph plots the mean ± SEM of latency. Each animal received 2 trials per day. The normal variables. Continuous variables will be tested for normality by Shapiro- control (NC; n=5) and vehicle control (P-Veh; n=6) rats when compared to Wilk’s test. Comparison between groups for autonomic, biochemical picrotoxin infused (Picro; n=4) rats performed better though not statistically and electrophysiological variables will be done using analysis of significant. All groups showed improved performance by decrease in the latency. ANOVA with repeated measures followed by Bonferroni Post-hoc test variance (ANOVA) / Kruskal-Wallis tests. Relationship between was applied to determine statistical significance variables will be established using Pearson’s/ Spearman’s correlation.
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Association between categorical variables will be done using Chi- the molecular mechanism and benefits of antidepressant treatment Square test. P < 0.05 will be considered statistically significant. and environmental enrichment, and also their beneficial effects in alleviating stress-related abnormalities. The findings will help in 26. Role of enriched environment and antidepressants treatment identifying, designing and developing novel therapeutic interventions on chronic stress-induced cognitive deficits. Ms. Shilpa BM. for treatment of stress and stress-associated cognitive deficits. Guides: Dr. BS Shankaranarayana Rao (Funding by CSIR- SRF) 27. Role of enriched environment and antiepileptic drugs on epilepsy-induced cognitive deficits. Ms. Vrinda M. Guides: Dr. BS Shankaranarayana Rao, Dr. Bindu M Kutty (Funding by CSIR-SRF)
Enrichment restored BDNF expression in the hippocampus and amygdalar complex of depressed rats. Left panel shows representative immunoblots of BDNF and β-actin from different groups of animals. Right panel shows the differential expression of BDNF in different brain areas with respect to chronic stress and environmental enrichment. Data expressed as Mean ± SEM. NC: Normal control; ST: Animals subjected to ten days of chronic immobilisation stress (CIS); ST + EE: CIS rats exposed to 6h of EE for 14 days; ST + Gap: CIS followed by 14 days of standard housing; EE: Normal animals exposed to 14 days of enriched environment. One-way ANOVA followed by Tukey’s post hoc test, *p<0.01; **p<0.01 vs. NC. #p<0.05; ##p<0.01 vs. ST. Values were normalized to β-Actin and compared with normal controls. Each group consisted of 5 rats.
Chronic stress results in cognitive deficits including anxiogenesis and depressive symptoms. The neural basis of amelioration of these deficits is not completely understood. Accordingly, the investigators evaluated the role of antidepressant drug, escitalopram (SSRI - a selective serotonergic reuptake inhibitor) in alleviating chronic stress- induced depression and cognitive deficits. The previous studies have showed that chronic immobilisation stress (CIS) induced behavioral depression along with learning deficits and decreased dentate gyrus (DG) and hippocampal volumes. CIS animals demonstrated high anxiety and hypertrophy of basolateral amygdala (BLA), escitalopram, FFT based alterations in the amplitude spectrum in the left and right treatment ameliorated CIS-induced behavioral depression, spatial hippocampal Local field potentials (LFP) from different groups of animals learning and memory deficits along with the restoration of DG and at 28th and 45th days post status epilepticus (SE). A and B: Normal Control (n=5); C and D: Epilepsy per se (n=3): E and F: Epilepsy + levetiracetam (n=5), hippocampal volumes. In the present study, both antidepressants and and G and H: Epilepsy + enriched environment (n=3) groups. BL-Baseline; d28 enriched environment (EE) attenuates the depressive-like symptoms (28 days post SE); d45 (45 days post SE), HpL, Left hippocampus left; HpR, and ameliorated depression-induced spatial learning and memory Right hippocampus. One-way ANOVA followed by post hoc permutation tests with FDR corrections was applied, but no significant difference observed impairments. In parallel, it was also observed that these interventions across groups. restored the levels of BDNF, VEGF and GFAP effectively in the hippocampus and amygdalar complex. The study suggests that the positive modulation by EE is responsible for amelioration of stress Temporal lobe epilepsy (TLE) is the most common form of focal associated cognitive deficits. The present study provides insight into epilepsy and is often intractable. Cognitive impairments are the
National Institute of Mental Health and Neuro Sciences 193| Annual Report 2014-15 hallmark of TLE, but are often associated with comorbid conditions 29. Depression-induced cognitive deficits: Effect of modulation like anxiety and depression. TLE is characterised by spontaneous of glutamatergic transmission and brain stimulation reward. recurrent seizures. In the present study, a rat model of chronic TLE Ms. Suwarna Chakraborty. Guides: Dr. BS Shankaranarayana has been used to assess the behavioural and electrophysiological Rao, Dr. TR Raju (Funding by NIMHANS) correlates of cognitive impairments associated with epilepsy. The effect of chronic treatment with levetiracetam, an anti-epileptic drug The major endogenous depression is characterized by reduced or enriched environment or both combined was studied. Local field monoamines, neurogenesis, synaptic plasticity and altered potentials (LFP) were recorded from the hippocampus. Hippocampal glutamatergi c transmission leading to deficits in cognition LFP data of epileptic rats during the post status epilepticus (SE) and reward. The pharmacotherapies targeted towards glutamatergic period indicate an increase in amplitude of low frequency bands (delta system and reward pathways may be beneficial for major depressive and theta) especially on 28th and 45th day of post SE. This increase disorders. Accordingly, the researchers investigated the effect of was found to be reduced in drug-treated group and not the enriched modulation of glutamatergic system and brain stimulation reward environment group. to rescue endogenous depression in rats. The chronic treatment with N-acetyl-cysteine (NAC), a glutamatergic modulator (50, 100 mg/kg 28. Role of amygdala in stress-induced cortical plasticity. Mr. body weight, i.p., for 14 days) significantly rescued depression-induced Sunil Jamuna Tripathi. Guides: Dr. BS Shankaranarayana anhedonia and enhanced anxiety and depressive-like behavior in a Rao, Dr. TR Raju (Funding by CSIR-SRF) neonatal clomipramine model of endogenous depression. This study will provide effective strategies to combat depression and depression- Chronic stress leads to deleterious neuromodulatory changes that associated cognitive deficits. impair cognition and functioning of the prefrontal cortex (PFC). The basolateral amygdala (BLA) plays an imperative role in stress-induced alterations and modulates the functioning of the PFC. Accordingly, the role of temporary inactivation of BLA on chronic immobilization stress-induced dysfunction in prefrontal cortical functions was investigated. The results showed that chronic stress-induced deficits in prefrontal dependent learning in the novel object location test and hypotrophy of PFC were prevented by inactivation of the BLA. The study provides conclusive evidence that the stress-induced deficits may be prevented by modulating BLA-mPFC connections.
The chronic N-acetyl-cysteine treatment rescues depression-induced behavioral despair, anhedonia and anxiety. Figures A and B shows depression- induced behavioral despair and anhedonia were reversed by chronic treatment with N- acetyl-cysteine. Figures C and D shows elevated anxiety- like behavior in depressed animals were restored by chronic treatment with N-acetyl-cysteine (50, 100 mg/kg body weight, i.p.). Data were expressed as Mean ± SEM, ***p<0.001, **p<0.01, *p<0.05 vs. Normal Control; $$$p<0.001, $$p<0.01, $p<0.05 vs. Depressed.
30. Spontaneous recurrent seizures induced cellular plasticity Temporary inactivation of BLA during stress prevents the stress-induced in the hippocampus. Ms. Kala P. Nair. Guides: Dr. BS deficits in novel object location test and hypotrophy of the prefrontal cortex Shankaranarayana Rao, Dr. Bindu M Kutty (NIMHANS (PFC). Figure A: Stressed group unable to discriminate between the novel and the familiar object while inactivation of BLA by lidocaine (LI+ST) group Intramural Funding) spent more time with novel object as compared to the familiar object in novel object location test. Figure B, C and D: Chronic stress-induced reduction in layer II volume of the anterior cingulate, prelimbic and infralimbic cortices is Epilepsy is a common chronic neurological disorder characterized prevented by temporary inactivation of the BLA. Data expressed as Mean ± by recurrent spontaneous seizures due to hyperexcitability and SEM; normal control (NC), stress (ST), lidocaine + stress (LI+ST), vehicle saline hypersynchrony of brain neurons. The epileptic seizures are associated + stress (VC (SAL) + ST), lidocaine per se (LI per se) and lidocaine + sham (LI+SC) groups of rats.*p< 0.05,***p< 0.001 vs.NC; #p<0.05 ###p<0.001 vs. ST, One-way with learning and memory impairments. Among different types ANOVA followed by Tukey’s post hoc test. of epilepsy, temporal lobe epilepsy is the most common one and is
194 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 characterized by recurrent seizures, which is often refractory to drug M Kutty (Funding by CSIR and ICMR Senior Research therapy. It has been reported that enriched environment is shown to Fellowship) be helpful in treating animal model of stress, Alzheimer’s, Parkinson’s and Huntington’s disease. In addition, enriched environment is shown to be effective in enhancing hippocampal neuronal plasticity and improves hippocampal dependent learning and memory functions in animal models. Therefore, the current study assesses the effect of enriched environment on cellular and molecular changes associated with epilepsy-induced cognitive deficits. Lithium-pilocarpine model was used to induce temporal lobe epilepsy in Wistar rats. Cellular and molecular changes in terms of structural alterations, glial responses, neuronal death, synaptic plasticity, calcium binding proteins following epileptogenesis is being studied. The temporal lobe epilepsy (TLE) - induced structural and cellular plasticity in the hippocampus has been studied. Further the investigators studied the differential vulnerability of GABAergic cell loss and synaptic plasticity by studying the alterations in the expression of GAD 67, parvalbumin, calbindin, Fig 1. Average peri-stimulus time histograms of all PVN neurons that were and synaptophysin in the hippocampus in epileptic animals. The role significantly responsive to tone of 10 seconds bin size. Black bar shown NMS rats and Grey bar represents MS rats. Recording done at habituation context of enriched environment on TLE induced abnormal structural and A and B, 24 hours after fear conditioning and during extinction training stage cellular plasticity in the hippocampus was also evaluated. (n=12 neurons per group, 100ms bin size).
Qualitative analysis of PV positive neurons in CA1 subfield of the hippocampus showed significant loss in stratum pyramidale in epileptic group when compared to normal animals (black arrows). In addition epileptic rats which were subjected to six hours of EE for 14 days showed no alterations in their numbers.
Fig 3: Waveforms of three representative Paraventricular nucles of hypothalamus neurons recorded during preconditioning (left), 24h post- conditioning (middle), during extinction training(right). Bottom, principal Effect of enriched environment (EE) on Parvalbumin positive interneurons component (PC) analysis of these neuronal waveforms al all five time points in CA1 region of the hippocampus. Representative images showing effect of EE on PV positive interneurons in CA1 region of the hippocampus in epileptic rats. (A) Normal control, (B) Epilepsy, (C) EP + 6h of EE, (D) EE per se. Arrows indicate PV positive interneurons. Scale bar in first column = 600 µm, second Early maternal separation and isolation stress during stress column = 300 µm and last two columns = 100 µm. hyporesponsive period (SHRP) is critical for the development, maintenance and recall of fear retention and extinction memory in 31. Impact of early life stress on the behavioural, the rodent model. The brain response to the acute stressor like fear electrophysiological and epigenetic factors in rats. Mr. conditioning and fear extinction involves hypothalamic- pituitary- Pradeep Kumar Mishra. Guides: Dr. Laxmi T Rao, Dr. Bindu adrenal (HPA) axis. The alteration in this stress response as a reaction
National Institute of Mental Health and Neuro Sciences 195| Annual Report 2014-15 to any threat (physiological or systemic) - involves two important brain areas, infra-limbic cortex (IL) and paraventricular nucleus of hypothalamus (PVN). During stress, the brain signals from multiple regions of the brain send input to the PVN. The PVN has strong projections to both sympathetic and parasympathetic nuclei. These nuclei in turn receive direct input from neurons in the IL, the central nucleus of amygdala (CeA) and the PVN. Although definite evidences available to state that, activity of neurons are prime determinant of animal behavior. In the present study, it has been shown, how the change in neuronal activity of the PVN neurons differ in stressed group in response to conditioned stimulus and extinction training. The conditioned tone responses of PVN neurons increased significantly in MS group 24 after conditioning and decreased during extinction Figure B: Number of omissions. Data expressed as mean±SEM. n= 3 training. Thus, the PVN can act as crucial part of HPA axis recruited Valproate (VPA ) rats, 6 Saline Control (SAL) rats. Two-way ANOVA followed by into cortico-amygdala network for fear retrieval and extinction “Bonferroni correction tests”. (***p<0.001) memory and has significant impact on stress response.
33. The role of constraint induced movement therapy (CIMT) in 32. Prenatal Valproic acid exposure in rats: The neural cortical plasticity in animal model of intracortical ischemic mechanism of changes in attention. Ms. Kumari Anshu. stroke. Ms. Nesin Mathew. Guides: Dr. Laxmi T Rao, Dr. Guides: Dr. Laxmi T Rao, Dr. Shoba Srinath (Funding by Anupam Gupta (Funding by UGC) UGC)
Constraint-induced movement therapy (CIMT) is found to be The investigators study attention in a prenatally induced Valproic an effective rehabilitation strategy to regain the functional activity acid (VPA) rat model of autism by examining long- range neuronal of upper limb in ischemic stroke patients. Through this study, synchrony between the medial prefrontal cortex (mPFC) and posterior investigators are trying to understand the underlining mechanism of parietal cortex (PPC). the neural plasticity after CIMT and also the extent to which CIMT helps in re-attain the fine movement in rodent model of ischemic The prenatal Valproate model of autism was standardized and stroke. validated for autism like symptoms using different behavioural tasks. The animals were evaluated for different aspects of attentional control The intracortical Endothelin-1 model of ischemic stroke was using a five-choice serial reaction time task (5CSRTT). VPA exposed standardized and validated with gait analysis, cylinder test and TTC rats showed impaired attention compared to controls as they took staining. There was a significant increase in performance after CIMT more sessions to reach target criteria (≥ 80% response accuracy and in stroke rats when tested for fine motor skills using reach to grasp <20% omissions) and had a significantly higher omission rate. task.
Figure A: Number of sessions taken to reach the target criteria (≥ 80% Response Accuracy and < 20% omissions).Data expressed as mean±SEM. n= 3 Valproate (VPA ) rats, 6 Saline Control (SAL) rats. Two-way ANOVA followed Fig A:Cylinder test showed significant ipsilateral bias after ischemic stroke by “Bonferroni correction tests”. (***p<0.001) (n=7; Paired t-test, * P< 0.05).
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Fig B Reach to grasp task: Both ISC groups (*** P< 0.001) and ISC+CIMTgroups ($$P<0.01, $$$P<0.001) (ANOVA followed by Tukey’s post hoc test) showed Figure: Total duration of sleep (NREM & REM) and total duration of wake (W1 significant decrease in percentage of success compared to NC group. & W2) in percentage. NC: Normal control, VPA: Valproate exposed group, SAL: Significant increase in percentage of success was seen for ISC+CIMT Saline treated group. Data expressed as mean±SEM. n= 5 NC rats, n=4 VPA compared to ISC group on D17 (ANOVA followed by Tukey’s post hoc test, rats and n=2 SAL rats. Two-way ANOVA followed by “Bonferroni correction ###P<0.001). NC (n=9) showed Consistent performance. tests”. (*P<0.05, **P<0.01)
34. Early maternal separation stress-induced anxiety and its relation to anterior cingulate cortex functions in processing Neurosurgery of emotional tasks. Ms. Maltesh Kambali. Guides: Dr. Laxmi T Rao, Dr. Ravi Muddashetty (Funding by NIMHANS) 1. Traumatic brain injury project phase -1. Investigators: Prof. B Indira Devi, Dr. Dhaval P Shukla, Dr. Manjul Tripathi Considerable evidences suggest that any insults such as maternal (Funding by Medtronic INC. USA) separation stress, isolation stress, environmental stress (exposure to an endotoxin1) during early developmental period known to have This project aims to find out the pattern of referral to NIMHANS. significant effect on normal physiological development of brain and From these findings the investigators hope to come out with increases vulnerability to psychopathology in adult life. guidelines for referral to the center and develop protocols for pre- hospital triage. This early life stress precipitates into a permanently altered anxiety- like behaviour associated with changes in emotional and cognitive 2. Endothelial Nitric Oxide Synthase Polymorphysim in the capacities in adulthood. A candidate brain region involved in both natural history of SAH. Investigators: Dr. B Indira Devi, Dr. cognitive and emotional behaviour such as anterior cingulate cortex, Rita Christopher, Prof. D Nagaraja (Funding by ICMR) how its function is altered not yet well know. Therefore in the present study we are going to access neural activity, behaviour and molecular The various polymorphysims of nitric oxide synthase and the level of marker expression in anterior cingulate cortex at adulthood in the nitric oxide were estimated in angio graphic proven SAH and also in animals subjected to early life maternal separation stress. angio negative SAH. Levels and expression of various polymorphisms correlated with vasopasm and outcome. 35. Prenatal exposure of Valproic Acid in rats: Effect on sleep architecture. Mr. UD Kumaresan. Guide: Dr. Laxmi T Rao 3. Cortical Plasticity following neurotisation for brachial plexus injuries. Investigators: Dr. Dhananjaya I Bhat, Dr. B Main findings of the present study are that rats with prenatal Indira Devi (Funding by DST) valproate exposure have induced alterations in sleep architecture, even though these rats did not show the core features of autism phenotype. Following injury to the brachial plexus the motor cortex undergoes The detailed Polysomnography result includes decreased wake and reorganization. This early reorganization can be prevented by a increased REM sleep. This study indicates that VPA is likely to play range of motion exercises and respirator synthanetic exercises. If the an important role in the regulation of sleep-wake cycle, particularly reorganization is not prevented at this stage the recovery following in the timing and duration of REM sleep. Further studies need to neurotization will not be adequate or useful. These changes are be conducted with a larger sample size and to evaluate different documented using resting of fMRI and task based fMRI and DTI concentrations and dosage of prenatal valproic acid administration. both pre and post neurotisation.
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4. Glioma serum biomarker discovery through proteomic categorising patients with high risk of recurrence and guide clinical approaches. Investigator: Dr. Arivazhagan A (Funding management. by DBT, New Delhi; multi-institutional project between NIMHANS and IISc, Bangalore) 7. Prognostic implications of clinicoradiological, immunohistochemical and neuropathological features of The study has identified novel proteins through LC MS/MS atypical meningiomas. Investigators: Dr. Dwarakanath, Dr. technique which are differentially expressed in sera of GBM patients Vani Santosh, Dr. Sampath S (Funding by NIMHANS) when compared to control samples. Further functional studies are in progress to understand the biological significance of these findings. 8. Development of artificial intelligence tool utilizing The investigators have identified a novel cytokine signature for clinical neurological examination for clinical diagnosis in identification of glioma by serum technique. Also, the role of MCSF neurosurgical patients. Investigators: Dr. Vikas V, Mrs. in glioma has been studied in detail. Sindhu MG, Dr. KVL Narsing Rao, Dr. Sampath S (Funding by DST) 5. Development of intra-operative Electrocorticography recording electrodes for surgery for refractory epilepsy. The project aims to mimic physician logic using artificial intelligence Investigators: Dr. Arivazhagan A (Funding by DBT; multi- techniques to evolve software packages for the diagnosis of institutional project between NIMHANS, Bangalore and neurosurgical diseases. Emphasis is on the arrival at diagnosis from DEBEL, DRDO, Bangalore) objective clinical findings, which are reproducible.
This project aims to develop indigenous electrodes which can be used 9. Evaluation of the role of endothelial nitric oxide synthase for intra operative electrocorticography. At present, development of gene variants in the natural history of aneurysmal sample electrodes is underway. subarachnoid hemorrhage. Investigators: Dr. B Indira Devi, Dr. Rita Christopher, Dr. D Nagaraja (Funding by ICMR) 6. Chromosomal Aberrations in Atypical and Anaplastic Meningiomas: Prognostic Implications. Investigators: The objectives of this study were to determine whether genetic variants Dr. Dwarakanath, Dr. Vani Santosh, Dr. Sampath S, Dr. of the endothelial nitric oxide synthase (eNOS) gene are associated Nishanth (Funding by DST) with increased risk for aneurysmal subarachnoid hemorrhage (aSAH), elucidate whether the gene variants alter the bioavailability
The aim of the study was to analyse deletions in regions 22q, 18p11, of nitric oxide (NOx) in the vascular system and lead to vasospasm, 1p32 and 14q32 in grade II and Grade III meningiomas and their and to identify whether the gene variants distinguish genetically correlation with tumor grade and recurrence. between small and large ruptured aneurysms. A total of 250 aSAH patients and 250 healthy age and gender-matched controls have been Fifty ninesamples from 50 cases of Grade II and Grade III genotyped for eNOS4ab, 894G>T and -786T>C. Although a positive meningiomas were analysed with fluorescence in situ hybridization association was observed between carriers of the eNOS-786T allele (FISH) technique with locus specific probes. Types of aberrations and and the risk of aSAH, no significant association was observed in the deletions were analysed and correlated with the tumor status. other eNOS variants. No association was observed between eNOS
variants and the size of the aneurysms. Plasma NOx levels were found There was a statistically significant increase in deletions in recurrences to be significantly decreased patients with aSAH and was associated when compared to primary surgeries. The mean mitotic index was with development of vasospasm. higher in patients with deletions. Patients with 18p deletions tended to occur in younger patients and had a significant association with 10. Role of ubiquitin c terminal hydrolase and s-100β in sheeting. 22q deletions were associated with hypercellular tumors. 1p, predicting deficits in cognitive control in young adults with 14q and 1p14q co-deletion had a significant association with mitosis mild traumatic brain injury - a prospective study. Col. (Dr.) ≥7. Subir Dey, Guides: Dr. Jagath Lal, Dr. Dhaval Shukla, Dr. Rita Christopher, Dr. Keshav Kumar This is a first study from India analysing deletions of all these four sites for deletions using FISH technique. Recurrent tumors and tumors The objective of this study was to identify serum biomarkers in patients with tendency to recur have a higher frequency of deletions. FISH with mild traumatic brain injury (mTBI) and correlate with cognitive study can be used to predict behaviour of meningioma if significant deficits. The study showed a marginal increase in serum S100B and association is found which needs extensive studies. Further studies in UCH-L1 levels in patients with mTBI. Patients with mTBI had larger sets of patients’ along with clinical correlation would help in significant cognitive deficits at three months after injury, suggestive
198 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 of involvement of diffuse areas of brain, particularly premotor, Vinaykumar. Guides: Dr. S Sampath, Dr. Nupur Pruthi, Dr. prefrontal and medial inferior frontal lobes and basitemporal region. Aravinda The correlation of biomarkers with cognitive deficits in mild head injury was found in the following domains: working memory, verbal The investigators plan to evaluate patients with supratentorial gliomas learning, verbal fluency, and visual memory in short term. in proximity to long descending tracts with DTI studies to assess the extent of involvement of the same. Following surgery, evaluation with 11. Molecular genetic basis of radiation and chemo-resistance in DTI will be doneto look for changes in the long descending tracts glioblastoma. Dr. Arun HS. Guides: Dr. S Sampath, Professor pertainingto course, displacement and disruption, along with clinical of Neurosurgery, Dr. Vani Santosh, Dr. Arivazhagan A correlation and prognostication.
In view of the high mortality associated with glioblastoma (GBM), The aim of the present study is to assess the extent of involvement a grade IV brain tumor, a search for potential therapeutic targets of long descending tracts due to the lesion, evaluate changes in DTI remains the need of the hour. In view of this the investigators asked parameters following surgical resection and correlate postsurgical if molecules associated with poor prognosis in gliomas do so through DTI findings clinically. conferring therapy resistance. The investigators selected Insulin- like Growth Factor Binding Proteins -3(IGFBP-3), Osteopontin 14. Cortical plasticity in Paediatric brain following both direct (OPN), Nicotinamide N Methyl Transferase (NNMT), MELK to and indirect trauma. Dr. Kislay Kishore. Guides: Dr. B address their clinical significance and their putative role in radiation Indira Devi, Dr. Dhanjaya I Bhat (Funding by ICMR) resistance. It was noted that grade specific expression of these molecules identify IGFBP-3, OPN and NNMT as GBM specific 15. Expression of cathepsin B, K, S, and Elastin in intracranial markers. Investigators also noted NNMT to be primary GBM aneurismal walls. Mr. Arun Babu. Guides: Dr. Dwarakanath, specific. They further identified STAT1 as a molecule downstream of Dr. Vani Santosh IGFBP-3 to be strongly associated with the poor prognosis in a cohort of 154 uniformly treated GBM patients. Further it was noted that This is the first gene expression study of intracranial aneurysm the nuclear expression of STAT1 was strongly associated with both performed in the Indian population and the investigators have poor overall survival and early disease progression in the p53 positive obtained the following unique results which have not been evaluated GBMs. In view of the above two molecules, NNMT and STAT1 in previous studies: (a) The patients with larger aneurysm and lower were further evaluated for their functional role in an invitro system. systolic BP at admission had higher level of TIMP4 expression level Two glioma cell lines U251 and LN229 were selected based on the in the aneurysmal sac (b) The increased expression of CTSB in the expression pattern of the selected proteins. ShRNA approach based aneurysmal sac is associated with higher incidence of hydrocephalus gene knockdown followed by clonogenic assay was performed. While at presentation (c)The incidence of fresh neurological deficits or neither of the molecules was associated with radiation tolerance in worsening of the preexisting deficits in the post-operative period is glioma, the invasive role of STAT1 was noted on matrigel assay which associated with lower level of CTSB expression in the aneurysmal sac. was further validated on GBM tumor tissue samples. 16. Molecular stratification of pediatric infratentorial 12. A study of inflammatory markers and heart rate variability in ependymoma- correlation with clinical parameters. Dr. severe head injury. Dr. Akhil Deepika. Guides: Dr. B Indira Nagarjun MN. Guides: Dr. S Sampath, Dr. Vani Santosh, Dr. Devi, Dr. Dhaval P Shukla, Dr. Rita Christopher, Dr. TN Jagath Lal G Sathyaprabha The present study clearly portrays the significant effect of clinical Patients with severe traumatic brain injury were recruited, clinical and biomarkers on overall and recurrence free survival of children parameters and CT scan findings are recorded, and blood inflammatory with infratentorial ependymomas. The brief findings of the study markers collected on day 1, 3 and 10 after injury. Heart rate variability are: (i) The clinical factors influence overall survival whereas was recorded on day 1, 3 and 10. Outcome measures such as GOSE, biomarkers influence recurrence free survival (ii) Greater extent DRS were applied and patients divided into the following groups (i) of resection and administration of adjuvant therapy are seen to braindead, (ii) patients with favorable outcome (GOSE 5 to 8) (iii) be significantly associated with improved overall survival whereas patients with unfavorable outcome (GOSE 1 to 4). The collected data younger age of presentation is significantly associated with poor will be analysed using appropriate statistical measures. overall survival (iii) Expression of EGFR and presence of true rosettes are associated with reduced recurrence free survival, whilst 13. Role of diffusion tensor imaging in evaluation of gliomas CBX 7 expression is associated with longer recurrence free survival involving eloquent areas of brain. Dr. Kaku Mayur in anaplastic tumors.
National Institute of Mental Health and Neuro Sciences 199| Annual Report 2014-15
17. Proteome profile of medulloblastoma correlation with The serum Institute of India, Pune has developed a new purified histology, molecular subtypes and clinical parameters. Dr. Vero cell rabies vaccine using micro-carrier technology and affinity Vinayak Narayan. Guides: Dr. S Sampath, Dr. Vani Santosh, chromatography purification. The vaccine was evaluated in phase I Dr. Arivazhagan A and II trials and phase III trial is ongoing. The immunogenicty of the new vaccine is excellent and there were no major side effects. The investigators have carried out a pilot study on the proteomic and phosphoproteomic profile of histological subtypes of Medulloblastoma 4. In vitro and in vivo studies on efficacy of 5 human monoclonal (MB). This study identifies different phosphorylation patterns and antibodies against rabies virus. Investigators: Dr. SN differential protein expression across various histological subtypes Madhusudana, Dr. Reeta Mani, (Funding by Celltrion, of MB. The investigators identified 2565 proteins: 43, 51 and 272 South Korea) were differentially up-regulated among the classical, desmoplastic and anaplastic subtypes respectively, as compared to normal. The The Celltrion, Korea has developed several human monoclonal prospective cases were further classified molecularly using the IHC antibodies using phage display and recombinant technology. In markers GAB1, YAP1 and β-catenin as described by Northcott, et this study, five human Mabs with different epitopes were tested al. Proteomics profile amongst the molecular subgroups are being both by in vitro and in vivo techniques to assess their rabies virus evaluated neutralization efficacy. They were tested against 10 different street rabies viruses prevalent in India. All the human Mabs were capable of neutralizing 10 street viruses in concentrations as low as 10 Neurovirology micrograms of protein.
1. Immunopathogenesis of rabies studies in murine model. 5. Development and evaluation of a direct rapid histochemistry Investigator: Dr. SN Madhusudana (Funding by DBT) test (dRIT) using polyclonal N antibody against rabies virus. Investigators: Dr. SN Madhusudana, Dr. Reeta Mani In this ongoing project, immunological parameters involved in (Funding by WHO, SEARO, India) pathogenesis of rabies encephalitis in a murine model are being investigated. Ongoing experiments have shown that there is significant Currently, the cocktail of N Mabs used for dRIT is produced and increase in levels of proinflammatory cytokines such as IL -6, TNF supplied by CDC, Atlanta. There is a need to develop this technique alpha, IL 2 and chemokines such as Rantes and IP-10 in brains of indigenously. The SEARO, WHO funded a project for developing infected mice. Presently, T cell and B cell phenotyping in spleen and and evaluating a biotinylated polyconal rabies nucleoprotein antibody brain of infected mice is being carried out. The findings implicate raised in rabbits. The polyclonal antibody produced has shown immune mechanisms as one of the key parameter in pathogenesis of excellent results comparable to those obtained with monoclonal rabies. antibodies. The dRIT kit developed indigenously will be evaluated by CDC Atlanta USA shortly. 2. Safety and immunogenicity of a recombinant rabies G protein vaccine in healthy volunteers. Investigator: Dr. SN 6. Self-sustaining diagnostic services (Molecular Diagnostics). Madhusudana (Funding by Cadila Pharmaceutical India) Investigators: Dr. Reeta Mani, Dr. Manjunatha MV (NIMHANS Intramural Funding) For the first time in the world, Cadila Pharma in collaboration with Novovax USA has developed a recombinant G protein vaccine against A total of ten new real time PCR based diagnostic assays have rabies. The phase I and II clinical trials were conducted and the been initiated as a part of these new services. These services are blood samples were analyzed for rabies virus neutralizing antibodies offered to patients from NIMHANS as well as other external/ by RFFIT. Different concentrations and schedules of rabies G private hospitals. protein were evaluated. The results indicate that 50ug of G protein administered on day 0,3,7 gives good and long lasting immune 7. Role of immune system dysregulation in postpartum response with minimal side effects. Currently, post exposure studies psychosis. Investigators: Dr. Reeta Mani, Dr. Harish T, are in progress. Dr. Prabha Chandra, Dr. Manjunatha MV (NIMHANS Intramural Funding) 3. Immunogenicity and safety of a new purified Vero cell rabies vaccine for post-exposure rabies prophylaxis. Investigator: Enrollment of study subjects and clinical sample collection is Dr. SN Madhusudana (Funding by Serum Institute of India, under progress. Procurement of reagents and standardization of Pune) immunological research assays relevant to the study is underway.
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8. Comparative Neurotropism of Dengue virus serotypes 1 to 4. 11. (i) Neuroimaging and neurocognitive correlates of Investigators: Dr. Anita Desai, Dr. Manjunatha MV immunomodulatory effects of neurrgulin in anti-psychotic naive schizophrenia (ii) A novel translational application of 9. Strengthening Japanese encephalitis surveillance in India. immunobiological parameters to predict treatment resistance Investigators: Dr. V Ravi, Dr. Anita Desai, Dr. Reeta Mani and metabolic side effects in schizophrenia. Investigators: (Funding by CDC) Dr. V Ravi, Dr. Venkatsubramanian, Dr. Anita Desai (Funding by DBT) Between March 2014 and April 2015, Department of Neurovirology, NIMHANS has received a total of 221 samples for testing from Schizophrenia is perhaps one of the most puzzling mental disorders various laboratories in the project. This includes 107 CSF samples whose etiopathogenesis is yet to be ascertained. Substantial research and 114 serum samples. The tests carried out on these samples include evidence from various lines of studies argues towards a compelling WNV IgM ELISA, Scrub typhus IgM ELISA, PCR for Streptococcus role for gene-environment interaction as a promising causal model pneumoniae, Hemophilusinfluenzae, Neisseria menigitidis, Enterovirus, for schizophrenia. Genetic, immunological as well as epidemiological Herpes Simplex Virus. studies implicate a robust role for immune-mediated pathogenesis in schizophrenia. The investigators used 21 drug naïve schizophrenia 10. Understanding the biology of Chikungunya virus infection and 19 control samples for the study. Briefly about 100ul of the blood in permissive cell lines and mosquito vectors. Investigators: was labeled with antibodies against CD3, CD16, CD56, CD4, CD8, Dr. Anita Desai, Dr. Brij Kishor Tyagi (CRME-ICMR, CD25, CD28, CD127, and CD45 in dim light conditions. This was Madurai), Dr. SN Madhusudana (Funding by DBT) followed by incubation in 40C for 20 min. RBC cells were lysed and cleared by addition of lysing solution. The remaining pellet obtained Excised samples of C6/36 membrane proteins were resubmitted to after centrifugation was suspended in staining solution and analysed C-CAMP, Bangalore for MALDI-TOF and MASCOT analysis. by flow cytometry. The investigators observed that the percentage Heat shock Cognate (HSC) 70 protein was identified as the putative of T-helper [CD4+] cells among T cell population was significantly receptor protein for CHIKV. Immunofluorescence Assay (IFA), higher in the schizophrenia compared to the healthy controls. This Plaque Reduction Assay and HSC 70 depletion on cell membrane by significance survived even after controlling for the confounding effect Quercetin with anti HSC 70 polyclonal antibody (Thermo Scientific, of age. Further, this effect was predominantly contributed by men. USA) further confirmed that HSC70 acts as a putative receptor for Also, in men, an increased trend in percentage of T regulatory cells CHIKV in C6/36 cells. among T helper population in schizophrenia compared to the healthy controls was observed. C2C12 cell membranes were resolved on 10% SDS PAGE, Virus Overlay Protein Binding Assay (VOPBA) performed and CHIKV 12. Immune signatures of responses to infection with Dengue interacting protein band identified ~66kDa. The protein band was Virus. Investigators: Dr. V Ravi, Dr. Anita Desai (Funding by submitted to C-CAMP, Bangalore for MALDI-TOF and MASCOT US – India Bilateral Collaborative Research Grant Funded Search Analysis (C-CAMP sample ID # 2174). by NIH, USA)
CHIKV non permissive U937 cells were obtained from Dr. Deepshika The current study aims to decipher the immune signatures in response Chakravorty, IISC, Bangalore. IFA was performed to confirm lack to dengue virus infection in a dengue endemic area by comparing the of infection of U937 cells by CHIKV. U937 cell membranes were responses in DENV infected patients and DENV exposed healthy resolved on 10% SDS PAGE and VOPBA was carried out to confirm controls (HCs). During the first year of this collaborative study, non permissiveness of U937 cells towards CHIKV as reported in 20 HCs and 35 DENV infected patients were recruited. The age literature. of the study subjects ranged from 21 to 60 years with 8 males, 12 females among HCs and 20 males, 15 females among patients. All Aedesaegyptiand Aedesalbopictusmosquitoes were orally infected with the patients were positive for NS1 antigen with typical features of CHIKV. The procedure of Real-time PCR assay to confirm CHIKV DENV infection. None of the patients developed either DHF or infection of Aedessp mosquitoes was standardised. CHIKV interacting DSS. Peripheral blood (10ml) was collected during acute infection proteins in mosquito midguts was identified by VOPBA. Additionally, from all patients and convalescent samples from 9 of these after four VOPBA was standardised to identify CHIKV interacting proteins months. Plasma and Peripheral Blood Mononuclear Cells (PBMCs) in mosquitoes from whole mosquitoes. CHIKV interacting protein were harvested and cryopreserved. Fluorescent antibody panels for band was identified ~140kDa for both species. The protein band was immunophenotyping of PBMCs based on HIPC guidelines were submitted to C-CAMP, Bangalore for MALDI-TOF and MASCOT obtained and antibody concentrations for staining were optimized. Search Analysis (C-CAMP sample IDs # 2178 and #2179). The investigators performed flow cytometry on PBMCs of two HCs
National Institute of Mental Health and Neuro Sciences 201| Annual Report 2014-15 using the antibody panels and found all the different cell types to be of certain individuals to neurotuberculosis for more effective in the normal range. PBMC samples from 20 HCs and 20 DENV treatment strategies. Innate and cell mediated immune responses in patients were shipped to Yale University for analysis. In addition, such individuals are being investigated in this study. the investigators carried out DENV serotyping on 29 patient serum samples by Real Time PCR and found DENV-1 in 35%, DENV-2 16. The molecular mechanisms involved in chikungunya virus in 45% and DENV-3 in 20% with no DENV-4 among the cases – host cell interaction. Mr. Ayushman Ghosh. Guides: Dr. tested. Anita Desai, Dr. SN Madhusudana, Dr. Gayathri N (CSIR)
13. National Family Health Survey-4. Investigator: Dr. Anita The selective tropism of Chikungunya virus (CHIKV) for bone and Desai (Funding by International Institute of Population joint associated connective tissues and skeletal muscles cells require Sciences, Mumbai) a greater understanding of this infection. The identity, distribution and behaviour of virus specific cell receptors on permissive cells at The National Family Health Survey commenced in March 2015. the primary level would help delineate a crucial step in virus-host The NRL, Department of Neurovirology is one of the five selected interaction. centres in the country to test the DBS samples collected after the interview for HIV antibodies. A total of 37,296 samples will be Also the virus induces certain changes in the cytoskeletal structure tested at NIMHANS. Samples from the linked states of Goa (1596), of the host cell during its life cycle within its host. This study aims Rajasthan (10,815), Karnataka (7644) and Andhra Pradesh (5985) to identify and characterize the cellular receptors for CHIKV on will be tested in phase I while samples from Gujarat (10,878), Dadra permissive cell lines. The investigators also wish to investigate the and Nagar Haveli (378) and Daman and Diu (777) will be tested in cytoskeletal changes in mouse myoblast cells following CHIKV phase II. infection and the role of lipid rafts in CHIKV entry into C2C12 cells
14. Study on molecular aspects of the pandemic Influenza A 2009 (H1N1) virus with special reference to host immune factors. Nursing Dr. Maria Thomas. Guides: Dr. V Ravi, Dr. Anita Desai 1. Development and evaluation of the effectiveness of integrated Influenza A 2009 (H1N1) is the first pandemic of the 21st century. audio visual aided interactive relapse prevention (IAVARP) While the overall global case fatality rate of the 2009 pandemic intervention among individuals with alcohol dependence H1N1 appears to be low, the fatality rate in India was relatively higher. at Central and State Government Mental Health Settings. The host responses play a crucial role in defense against influenza Investigators: Dr. Prasanthi Nattala, Dr. Pratima Murthy, but in some instances they may contribute to immunopathogenesis. Dr. Jayashree Ramakrishna, Dr. Sreevani Rentala (Funding Understanding the pathogenic events leading to severity is important by NIMHANS) for designing better strategies for prevention and treatment. In this study, the molecular aspects of the virus and the host immunological The aim of this study was to examine the effectiveness of a Video- factors that lead to the severity of the disease in comparison with Enabled Relapse Prevention Intervention (VERPI) for inpatients with seasonal Influenza viruses are being investigated. Alcohol Dependence. The VERPI comprises videos to portray various relapse prevention strategies, for example, dealing with peer pressures. 15. A comparative study of innate and cell-mediated immune The VERPI was tested at a Central Government (NIMHANS, responses in human immunodeficiency virus infected Bangalore) and a State Government (DIMHANS, Dharwad) setting. individuals with and without neurotuberculosis. Ms. At each of the sites, 30 inpatients were administered the VERPI, Deepashri Rao. Guides: Dr. Anita Desai, Dr. V Ravi, and were compared to 30 patients belonging to Treatment-As-Usual Dr. P Satishchandra (Total N=120; 60 from each site). Following discharge, six-month follow-up assessments were scheduled, to assess effectiveness of the At the end of 2013, there were 35 million HIV-infected people VERPI. around the world and 1.5 million deaths due to AIDS in 2013 alone. In individuals with neurologic disorders associated with HIV/AIDS, VERPI group performed better than TAU on all outcomes over the TB of the central nervous system is the most common opportunistic 6-month follow up(reduction in quantity of alcohol and number of neuroinfection. However, not all individuals with tuberculosis drinking days, increased time for relapse). Cox regression analysis manifest neurological symptoms. Understanding the role played showed that being in TAU group and early-onset alcohol dependence by host immune factors in such individuals is necessary to better (onset before 25 years) were significantly associated with relapse after understand the host response and address the issue of predisposition adjusting for baseline alcohol use and other covariates.
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Findings highlight the use of culturally relevant audiovisual and Neurosurgery specialty as group I and psychiatric specialty as aids as educational tools to teach relapse prevention in alcohol group II. The group III comprised clinical instructors working in the dependence. Findings also help to alert treatment providers that some clinical area. During this process the variables controlled were age, subsets of alcohol users might need more individualized interventions marital status, religion, type of family, highest degree, designation, and rigorous monitoring during follow-up. total experience, current experience, income per month, disability in dependents, travel distance to work, future plan in job, and the 2. The quality of life among tobacco users and non-tobacco opinion of finding job in nursing. Structured questionnaire was used users in NIMHANS Campus, Bangalore. Mrs. Rituparna to collect the data. Samanta. Guides: Dr. Ramachandra, Dr. Vivek Bengal Based on the analysis, it was observed that the psychiatric staff The aim of the study is to increase the understanding of the fact that nurses had better perception of job satisfaction in three domains tobacco use brings down the quality of life of tobacco users. A total as compared to neuro staff nurses, clinical instructors in three of 60 participants from two independent male populations of tobacco domains namely, working environment, emotional climate and users and non-tobacco users were recruited by using stratified simple salary and allied aspects. It was also observed that the psychiatric random sampling technique into a comparative study. A face-to-face staff nurses, neuro staff nurses and clinical instructors expressed interview technique was used to collect data on measures of quality of significant difference (P<0.05) in general domain like self-respect, life (QOL). The following were employed: a sociodemographic data practical guidance, independent thinking, freedom for expression of sheet; the World Health Organization Quality of Life Instrument, thoughts, doubts clarification, appreciation, the amount of pressure, brief version (WHOQOL-BREF); General Health Questionnaire, interest at work, reward, opportunity for development, learning 12 items (GHQ12) and the Fagerström Test for Nicotine Dependence environment, personal contribution, overall job satisfaction. (FTND) 4. Effectiveness of structured teaching programme on Findings suggested that Non tobacco users have better quality of life knowledge of primary care providers on the management of than tobacco users. Non tobacco users scored higher in each domain violent behavior in patients diagnosed with schizophrenia, of WHOQOL-BREF. There was statistical significant difference admitted in an inpatient facility, NIMHANS. Ms. Arpitha between QOL of both the groups in each domain of quality of life Elizabeth Jolly. Guides: Dr. K Lalitha, Dr. Shivarama (p<0.001). Majority (56.7%) of tobacco users showed evidence of Varambally psychological distress. There was significant difference among both the in GHQ12 (p<0.001). Selected sociodemographic variables The aim of the study is to improve the knowledge of primary care such as age, marital status, current residence were not associated providers on the management of violent behaviour in patients with quality of life but type of tobacco use (smoking and both ) was diagnosed with schizophrenia. significantly associated with quality of life (p<0.05). The study was conducted in the selected psychiatric open wards of Tobacco users had shown significantly poorer QOL and mental National Institute of Mental and Neurological Sciences., Bengaluru wellbeing as compared to non-tobacco users. The results pointed out using one group pretest posttest researchdesign on 32 primary care the importance of the strategic policies against smoking, to reduce providers of inpatients with schizophrenia who met the sampling morbidity and premature death, but also to increase the quality of criteria. Consecutive sampling technique was used to select the life and well-being. It is also important to consider the mental health subjects. dimension, since that best mental health can be relevant to promote healthier behaviors. Socio demographic Data Sheet and the Knowledge Assessment Tool developed by the researcher were used to collect the data. The tool 3. Job satisfaction among nursing personnel in an organization. consisted of 40 multiple choice questions with one correct answer Mrs. Rebecca K. Guides: Dr. Ramachandra, Dr. R and three distractors. Test –Retest method was used to establish Parthasarathy the reliability of the tool. The content validity of the tool and the structured teaching programme was ensured from mental health A study to assess and compare the job satisfaction among nursing experts. Pilot study was conducted to evaluate the feasibility of the personnel in an organization was undertaken. The descriptive research study. The structured teaching programme was administered to the design was adopted. NIMHANS were selected as universe of the study subjects on five consecutive days for a period 30 minutes. Pretest present study. A sample of 60 subjects who fulfilled the inclusion / was administered to the subjects prior to the structured teaching exclusion criteria participated in the study. The subjects for study programme and the posttests were conducted on the second day and were selected from staff nurses working in clinical areas of Neurology one week after the completion of the last session.
National Institute of Mental Health and Neuro Sciences 203| Annual Report 2014-15
The study findings showed that there was significant improvement The study was conducted at NIMHANS, Bengaluru, where Hospital in the knowledge scores before and after the structured teaching Management Information System is being implemented. The sample programme which showed the effectiveness of the intervention. size was 145 nurses. A total of 67 nurses from psychiatry wards and The study was found to be effective in improving the knowledge 78 nurses from Neuro Centre were selected by using stratified simple of the primary care providers on the management of violent random sampling. The tools were a socio-demographic data sheet with behaviour. The study has implications in Nursing education, 10 items, knowledge questionnaire with 50 items and a 5 point Likert practice, administration and research. The video for the nurses and scale with 40 items on attitude towards e-Hospital system. The validity the information booklet (in English and Kannada versions) for and reliability of the tool was established by test-retest method. the care providers developed by the researcher will pave way for continuity in teaching the needy. The study findings suggested that, there was a significant difference in the knowledge score between the study groups (p=0.001) 5. Effectiveness of a structured teaching programme on the whereas the attitude scores are not statistically significant. There knowledge about the human rights of mentally ill among was positive correlation between knowledge and attitude. None of the primary caregivers of inpatients with schizophrenia at the socio-demographic variables were significantly associated with NIMHANS, Bengaluru. Ms. Amrita Kuriakose. Guides: Dr. the knowledge or attitude except the gender. This study found that Sailaxmi Gandhi, Dr. Naveen Kumar the nurses had less knowledge on e-Hospital system whereas they had positive attitude towards its use in their practice. The gaps in The present study was adopted with an aim to enhance the knowledge the knowledge on HMIS were linked to lack of adequate training, on human rights of mentally ill among the primary caregivers of staff workload pressure or difficulty in accepting and adapting to inpatients with schizophrenia the technology in nursing practice. The findings suggested the need for more information and periodic training sessions on e-Hospital The study was carried out among the primary caregivers of system. Considering the above, the researcher developed a manual for persons with schizophrenia admitted at selected psychiatric wards the nurses on e-Hospital system. in NIMHANS, Bengaluru. A one group pre-test post-test design was adopted. Thirty five consecutive consenting subjects who met 7. Effectiveness of structured teaching programme on the inclusion criteria were recruited for the study. After the pilot knowledge regarding stress management among the study, data was collected with a tool developed by the researcher primary caregivers of patients diagnosed with schizophrenia that consisted of a socio-demographic profile and a knowledge admitted in selected psychiatric wards at NIMHANS. Ms. assessment questionnaire on human rights of mentally ill. Analysis Alphy Thomas. Guides: Dr. K Lalitha, Dr. Geetha Desai, Dr. revealed statistically significant (p<0.01) increase in the post- Mahendra P Sharma test 1 and post-test 2 mean knowledge scores on human rights of mentally ill following the structured teaching programme, and hence A quasi experimental study was carried out with the problem the hypothesis is retained. There was no statistically significant statement of effectiveness of structured teaching programme on association (p>0.05) association between the pre-intervention knowledge regarding stress management among the primary knowledge score and the socio-demographic variables of the study caregivers of patients diagnosed with schizophrenia admitted in subjects, and the hypothesis is rejected. selected psychiatric wards at NIMHANS. The study was carried out in the selected psychiatric open wards of National Institute of Mental The study findings significantly support that the structured teaching Health and Neuro Sciences, Bengaluru using the design of one group programme was effective in increasing the knowledge of the primary pretest-posttest design on 35 primary caregivers of inpatients with caregivers on human rights of mentally ill. The study has implications schizophrenia who met the sampling criteria. Consecutive sampling in nursing education, service, administration and research. technique was used to select the subjects. The study findings revealed that due to the structured teaching programme on stress management, 6. Knowledge and attitude towards e-hospital system among there was statistically highly significant difference in knowledge level nurses working in psychiatry wardsand neurocentre at between pre-test and post-test. There was also significant difference NIMHANS, Bengaluru. Ms. Sheeba Sara Daniel. Guides: between pre-test knowledge level and family history. Dr. Sailaxmi Gandhi, Dr. VL Sateesh The study was found to be effective in improving the knowledge of primary caregivers on stress and its management. The study has The aim of the studyis to explore, compare and correlate the knowledge implications in nursing education, practice, administration and and attitude towards e-Hospital among nurses working in Psychiatry research. The video for the caregivers and nurses and the Information wards and Neuro Centre at NIMHANS, Bengaluru and to develop a Booklet for nurses, developed by the researcher will pave way for manual for nurses on e-hospital system. continuity in teaching the needy.
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8. A study to assess care givers’ satisfaction with the services The age of the subjects ranged between 18 to 60 years and 58% of provided at Child and Adolescent Psychiatry in-patient the primary caregivers were males. Analysis of primary caregivers’ setting, NIMHANS, Bangalore. Mrs. SN Usha. Guide: Dr. knowledge and attitude showed that they had above average score in Prasanthi Nattala total knowledge as well as in total attitude regarding children with epilepsy. The primary caregivers who were between 31-40 years had The objectives of the study are: (a) to assess the satisfaction level significantly more knowledge regarding children with epilepsy than of caregivers about the services provided at inpatient setting of those who were 30 years or less and 41 years-60 years age groups Department of Child and Adolescent Psychiatry, NIMHANS (b) to (p=0.036).The primary caregivers working in government sector assess the relationship between caregivers’ total satisfaction score and had statistically significant higher knowledge compared to others selected baseline variables. (p=0.014). Also primary caregivers working in private sector had significantly more favorable attitude (p=0.001) compared to those This study was carried out at inpatient setting of Department of Child working in other sectors. There was no significant correlation between and Adolescent Psychiatry, NIMHANS, Bangalore on 30 subjects knowledge and attitude of the primary caregivers towards children using quantitative, descriptive approach. The subjects of the study with epilepsy. were selected using consecutive sampling method. The tool comprised two parts: Part I was baseline data of caregivers of children and Part II 10. Effectiveness of progressive muscle relaxation programme was the Inpatient Caregiver. on the occupational stress seen among housekeeping staff on contract basis in NIMHANS, Bangalore. Ms. Keerthini J. Satisfaction Scale developed by the researcher, consisting of 140 items Guide: Dr. K Lalitha with 14 domains for assessment of satisfaction, overall assessment and a section for the comments and suggestions of the caregivers at the The present study was designed with an aim to reduce occupational end of each domain. Data were collected using face-to-face interview stress by progressive muscle relaxation program on housekeeping staff method. on contract basis in NIMHANS, Bangalore.
The age of the subjects ranged between 19 to 57 years and 60% of the The study was carried out among 60 housekeeping staff on contract caregivers were females. Analysis of their satisfaction level showed that basis working in various psychiatric wards. A true experimental the subjects were highly satisfied with the services at inpatient setting design was adopted for this study. The study subjects were recruited of Department of Child and Adolescent Psychiatry. No statistically in to the experimental and control groups by using simple random significant difference was found in the caregivers’ total satisfaction sampling method. The experimental and control group consisted score between the various categories of the selected variables. of 30 housekeeping staff in each group of a total of 60. The pre- interventional occupational stress level was assessed by using the 9. A study to assess knowledge and attitude towards epilepsy occupational stress assessment tool to both the experimental and the among primary caregivers of children diagnosed with control group.The intervention progressive muscle relaxation program epilepsy at NIMHANS, Bengaluru, with a view to develop consisting of 30 sessions was administered by the researcher and also an information guide sheet. Mrs. D Lavanya. Guide: Dr. using video LCD on progressive muscle relaxation technique (PMR) Prasanthi Nattala to the experimental group and the control group was not provided with any intervention. The post test was administered to both the The aim of the present study is to assess knowledge and attitude experimental and the control group. towards epilepsy among primary caregivers of children diagnosed with epilepsy at NIMHANS, Bengaluru, and develop an information Analysis revealed statistically significant (P=0.01) decrease in the guide sheet for the primary caregivers. level of occupational stress which was seen in the experimental group. The control group had statistically (P=0.01) increase in the level of This study was carried out at the Outpatient Department of occupational stress without any intervention. There was no statistically Neurology, NIMHANS, Bengaluru, on 50 primary caregivers using significant association between the pretest scores of occupational quantitative, descriptive approach. The study subjects were selected by stress and all socio demographic variables of the study subjects except using convenience sampling method. The tool was developed by the in the ‘number of children’. researcher which consisted of three parts—Part I: Socio demographic profile, Part II: Knowledge Questionnaire consisting of 65 questions, The study finding significantly signifies that progressive muscle Part III: Attitude Scale consisting of 22 statements. Data were relaxation program was effective in decreasing the level of occupational collected using face-to-face interview method. stress seen among housekeeping staffs.
National Institute of Mental Health and Neuro Sciences 205| Annual Report 2014-15
College Of Nursing antenatal health behaviour and with pregnancy outcomes – a prospective study in an urban slum. Investigators: Dr. Prabha S Chandra, Dr. Geetha Desai, Dr. Kavita V Jangam, Dr. 1. Identification of Techniques to reduce Intramuscular Veena Satyanarayana, Dr. Thennarasu, Dr. Latha Venkatram, Injection pain in children (Project No.1). Investigators: Dr. Dr. Aruna Muralidhar (Funding by ICMR) Ramachandra, Dr. S Valliammal
The aims of this study are four fold. First the investigators will be 2. Technology addiction among undergraduate student nurses prospectively assessing both anxiety and depression among 650 (Project No.2). Investigators: Dr. Ramachandra, Dr. S women from their first trimester of pregnancy till the third trimester Valliammal, Mrs. Bingi Rajeshwari, Mrs. Sathyavathy N of pregnancy and within four weeks of childbirth. In addition, various psychosocial and psychiatric factors that might be a risk factor for 3. Psychiatric patients’ admission experiences in to Psychiatric poor mental health during pregnancy will be systematically assessed. Hospital. Investigators: Dr. Ramachandra, Mrs. P Next, impact of mental health and psychosocial factors on antenatal Vijayalakshmi, Dr. K Lalitha, Dr. Suresh Bada Math health behaviours such as antenatal clinic attendance, immunization during pregnancy, anemia and nutrition will be assessed. Finally, the 4. Academic satisfaction among the under graduate nursing investigators will assess the relationship between anxiety/depression students. Investigators: Mrs. Annie P John, Mrs. TS Sunitha, and pregnancy outcomes controlling for other psychosocial and Mrs. Padmavathi N, Mrs. G Jothimani, Dr. K Lalitha, Dr. obstetric variables. The research project will be a prospective Ramachandra longitudinal study of perinatal depressive and anxiety symptoms among women in three slums of urban Bangalore. The population of Psychiatry the study will comprise pregnant women. A cohort of 650 consecutive eligible and consenting women will be studied from the first trimester 1. The international prevalence and treatment of diabetes and of pregnancy to six weeks of the postpartum period. Baseline data on depression (INTERPRET-DD) study carried out under 250 participants has been collected so far. the auspices of the international dialogue on diabetes and depression (DDD). Investigators: Dr. Norman Sartorius, 4. Preventing and treating HIV Co-morbidities in India: Dr. Cathy Lloyd, Dr. SK Chaturvedi, Dr. Md. Ameer Multi-tiered strategy for women. Investigators: Dr. Prabha Hamza, S Srikanta and others from 19 countries (Funding by S Chandra, Dr. Veena Satyanarayana (Funding by ICMR/ International Dialogue on Diabetes and Depression (DDD) NIH, USA) for meetings) The objectives of the study are: (i) to conduct formative research to The pilot phase of the study was completed, following which for adapt a Nurse-delivered Mobile Phone Intervention for women with one year from December 2013 to December 2014, the baseline data HIV who have mental health or psychosocial barriers. This part of was collected for patients with diabetes, who underwent psychiatric the research will form the content of the intervention and help to assessment and evaluation. In this phase 240 patients were included. adapt the existing intervention for Indian needs (ii) to train Indian The one year follow-up of this case started in December 2014 and is nurses to deliver the theory-guided, standardized phone intervention ongoing at present. for mental health issues and psychosocial barriers to improve ART adherence and retention in care and improve clinical outcomes(iii) to 2. Psychiatric morbidity in patients with chest diseases evaluate the feasibility, acceptability, fidelity and preliminary efficacy including MDR TB. Investigators: Dr. SK Chaturvedi, Dr. of the standardized phone intervention in a randomized, controlled Harish T, Dr. SenthilReddi pilot study in which 120 HIV-infected women are randomized to Treatment As Usual or Treatment as Usual plus the Phone Screening of the outpatients with respiratory diseases was done using Intervention. NIMHANS screening instrument for psychiatric morbidity on 90 patients. The psychiatric morbidity was found to be 45 per cent. The Recruitment and training of research staff for the formative phase sensitivity and specificity of the screening instrument was found to be of the study has been done. Formative phase has been initiated, 0.71 and 0.77 respectively. Cases of MDR TB are being evaluated for and qualitative interviews on women with HIV/AIDS, their family psychiatric morbidity and well-being. members and health care providers are currently ongoing. Phase II, training of nurses in the self-care intervention, is complete. Phase III: 3. Prevalence of anxiety and depression among pregnant the RCT has been initiated and baseline data for 30 participants has women and association with antenatal healthcare utilization, been collected so far.
206 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
5. Default mode network as a predictor of Cognitive Ageing. Previous diffusion tensor imaging (DTI) studies in patients with Cognitive Science Research Initiative (CSI). Investigators: obsessive-compulsive disorder (OCD) have reported abnormalities Dr. Varghese M, Dr. John JP, Dr. Jain S, Dr. Bagepally BS of fractional anisotropy (FA). However, these results have been (Department of Science and Technology, New Delhi) inconsistent. Confounding effect of medications could be an important reason for this inconsistency as pharmacological treatment 6. Indo-US training program on chronic non-communicable could modify the structure of cell membranes and myelin sheaths. Till disorders (CNCD) and diseases across the life span. date, about 200 patients and 120 healthy controls have been scanned. Investigators: Dr. Sanjeev Jain, Dr. Mathew Varghese In addition, 46 drug-naïve patients have been rescanned after 3-6 (Funding by Fogarty International Center) months. Preliminary analyses of both gray and white matter structural differences based on symptom dimensions have been carried out 7. Shradha: A multimodal interface to desktop for elderly user and some interesting findings have emerged. Final analyses will be group. Investigator: Mr. Sreekanth NS, CDAC, Bangalore, performed after completion of the study in July 2015. Dr. Varghese M (Funding by DST-TIDE Program) 12. Alcohol: Harms to others -India. Investigators: Dr. Vivek 8. Targeted generation and interrogation of cellular models Benegal, Dr. Girish Rao (Funding by World Health and networks in neuro-psychiatric disorders using candidate Organisation and Thai Health) genes. Investigators: Dr. Sanjeev Jain, Dr. Mathew Varghese, Dr. Meera Purushottam (Funding by DBT) 13. Augmentation effect of low frequency-repetitive transcranial magnetic stimulation over supplementary motor area in Identification and recruitment of cases and controls for the study has obsessive compulsive disorder: a randomized controlled trial. been initiated. Protocol for generation of lymphoblastoid cell lines Investigators: Dr. A Shyamasundar. from peripheral blood lymphocytes has been standardized. LCL lines have been generated. Preliminary transcriptome data by RNA 14. Neural and Immunological predictors of SSRI response in sequencing has been generated for LCL lines. The method for gene OCD: search for a composite biomarker. Investigators: Dr. conversion is standardized. Janardhanan CN, Dr. YC Janardhan Reddy, Dr. Ganesan Venkatasubramanian (Funding by DST) 9. Genetics of movement disorders. Investigators: Dr. Sanjeev Jain, Dr. Pramod Pal, Dr. Meera Purushottam (Funding by Selective Serotonin Reuptake Inhibitors (SSRIs) form the mainstay ICMR) of treatment for OCD. However, nearly 40 to 60 per cent of patients do not respond satisfactorily to SSRIs. This project aims to study Patients and relatives are counselled prior to collecting the blood the structural and functional brain abnormalities, neurocognitive sample for genetic diagnosis of Huntington’s disease and dominant functioning and cytokine (immune) profile in drug free adult Ataxias, of which SCA1, 2, 3 are being predominantly tested for subjects with OCD at baseline and 12 weeks after SSRI treatment Degenerative Ataxias and Huntington’s disease and examine the relationship between these abnormalities and SSRI response, thus attempting to elucidate bio-signatures of response to 10. Novel gene modifiers of penetrance of Alzheimers disease treatment. 40 subjects with OCD have been assessed using a pre-post in carriers of apolipoprotein E (APO E) E4 alleles. design with structural MRI. Significant volume changes (p<0.001 Investigators: Dr. Sanjeev Jain, Dr. Mathew Varghese, Dr. uncorrected; with SVC for the masks) were observed in left middle Odity Mukherjee (Funding by ICMR) and inferior frontal gyri, left medial frontal gyrus and left anterior cingulate. Comparison of interleukin level 6 levels between patients Individuals with diagnosis of dementia have been sampled along with and healthy controls has been performed. age matched control subjects. The DNA isolated from blood has been used for genotyping at the APOE, CLU and PICLM loci. The data 15. Endocannabinoid-Glutamatergic interaction in OCD: collected shows association for APOE but not the CLU and PICAL cognitive translational implications. Investigators: Dr. M polymorphisms. Janardhanan CN, Dr. YC Janardhan Reddy, Dr. Ganesan Venkatasubramanian (Funding by DST) 11. White matter alterations in obsessive compulsive disorders and its relationship with symptom dimensions: A diffusion This project aims at examining a novel mechanism of pathogenesis tensor imaging study. Investigator: Dr. YC Janardhan Reddy of OCD – the interaction between glutamatergic system and (Funding by DST) endocannabinoid system in OCD. This study uses functional MRI,
National Institute of Mental Health and Neuro Sciences 207| Annual Report 2014-15 structural MRI, MRS, antisaccade eye movements and plasma expressions. Main pathways affected include energy metabolism, anandamide assessments to examine the aims. The subject recruitment signal transduction and cytoskeleton assembly. is ongoing. The study has shown some interesting preliminary findings such as elevated anandamide levels in OCD.
16. Structural and functional connectivity of hippocampus in schizophrenia: evaluation of neuroimmunological and neurotrophic factors interactions using diffusion tensor imaging and functional magnetic resonance imaging studies. Investigators: Dr. G Venkatasubramanian, Dr. BN Gangadhar, Dr. V Ravi, Dr. MS Keshavan (Funding by Wellcome Trust / DBT India Alliance)
17. Translational Research on the Neuroimmunopathology of Schizophrenia (Centre of Excellence and Innovation in Biotechnology – Institutional Programme Support). Investigators: Dr. G Venkatasubramanian, Dr. BN Gangadhar, Dr. V Ravi, Dr. SK Shankar, Dr. DK Subbakrishna, Dr. Anita Desai, Dr. Anita Mahadevan, Dr. Shivarama Varambally, Dr. Jitender Saini, Dr. Mariamma Philip (Funding by DBT)
This Centre of Excellence on Translational Research on A) Heatmap of molecules involved in cytoskeleton assembly for their fold Neuroimmunopathology of Schizophrenia is a unique and change in different schizophrenic brain regions considered for the study. B) Most differentially expressed molecules mapped to the synaptic vesicle cycle. translationally relevant collaborative research programme involving Differentially expressed molecules are represented in red. the Departments of Psychiatry, Neurovirology, Neuropathology, Neuroimaging and Interventional Radiology and Biostatistics at NIMHANS 18. Diagnosis and treatment response in antipsychotic naive schizophrenia: a clinical and arterial spin labeling study. The research evidences from the various angles suggests a compelling Investigator: Dr. Shivarama Varambally (Funding by Central role for epigenetic interactions and infections. Epidemiological Research Fund, University of London) evidence suggests increased risk for schizophrenia in the off springs born to mothers who had ante-natal maternal infections. The The study aims to investigate (i) whether antipsychotic-naive investigators examined human brain tissues (n= 27) from cases schizophrenia patients have more NSS and altered rCBF of Schizophrenia archived at Human Brain Bank and control compared to controls (ii) whether markers for treatment response brain tissues from road traffic accident victims. The investigators can be identified clinically and in basal resting state CBF before hypothesized that the immune cells in microglia and astrocytes located antipsychotic treatment is administered in first episode, antipsychotic in hippocampus, dorsolateral prefrontal cortex, and anterior cingulate naïve, patients with schizophrenia (iii) whether immediate cortex and dorsomedial thalamus showed alterations in numbers significant increase (i.e. four hours after first dose) in rCBF in basal and morphology. Four cases were positive for Cytomegalovirus and ganglia, frontal and temporal brain regions and lower NSS scores one for Herpes encephalitis as co-morbid infections (DNA Chip). will predict significant clinical improvement at the end of 6-weeks In serum and CSF using Autoimmune Encephalitis Mosaic 1 (IIFT (iv) temporal course of blood flow changes according to treatment Kit), no auto-antibodies were found to NMDA, AMPA-1, AMPA- response to understand biological mechanisms involved in different 2, Contactin associated protein 2/VGKC-2, VGKCA-1 associated antipsychotic action. LGI-1 and GABA B receptors. Serum and CSF samples analyzed by Multiplex Immune Essay for 14 Cytokines indicated associated 19. Clinical and functional correlates of cognitive deficits in inflammatory process elevating IL-6, IL-8, MCP-1, Rantes, IF schizophrenia. Investigator: Dr. Shivarama Varambally gamma, TNF alpha. (Funding by CIHR Canada Hope scholarship)
Proteomics analysis of brain carried out with LTQ- Orbitrap Fusion The aim of the study is to examine the relationship between cognitive Mass Spectrometer revealed 5,387 proteins, 499 showing differential deficits and social functioning in patients with schizophrenia.
208 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
20. Neurobiological effects of oxytocin on metacognitive deficits onset depression: A prospective study. Investigators: Dr. in schizophrenia: A pharmacological MRI – Imaging PT Sivakumar, Dr. Sanjeev Jain, Dr. Thennarasu, Dr. genetics study. Investigator: Dr. Shivarama Varambally Venkatasubramanian G, Dr. Jitendra Saini (Funding by (Funding by DST) ICMR)
The primary aim of the study is to obtain firstin-vivo imaging data, Depression in elderly with onset above 50 years age (late onset) using phMRI, investigating effects of single dose OXT on functional is associated with reduced hippocampal volume. APOE4 allele brain activation of neural networks underlying metacognition. and depression are considered as important risk factors for Thesecondary aim is to examine the effect of OXTR SNP rs2254298 dementia. This study evaluates the effect of APOE 4 allele and on this functional brain activation underlying metacognition. late onset depression on cognitive function and hippocampal volume. Genotyping, baseline MRI scan, clinical and cognitive 21. The efficacy of transcranial direct current stimulation assessment of 45 subjects with late onset depression have been (tDCS) as add-on treatment for major depression: A sham completed till now. Follow-up assessment of cognitive function controlled trial. Investigator: Dr. Muralidharan K (Funding and measurement of hippocampal volume after one year has been by Science and Engineering Research Board, Govt. of India) initiated.
It is documented that only about 35-40 per cent of major depressive 24. Augmentation of cognitive remediation in schizophrenia episodes respond and remit with standard antidepressant treatment. with transcranial magnetic stimulation: A randomized Residual symptoms are known to trigger of subsequent depressive controlled trial. Investigators: Dr. Thirthalli J, Dr. episodes, while also contributing to continued morbidity and Chaturvedi SK (Funding by DST) poor quality of life in these patients. There is a need to augment antidepressant treatment to improve outcomes in depression. This project will examine the effect of neuronavigated TMS on Transcranial direct current stimulation (tDCS) has shown promise cognitive retraining in patients with schizophrenia. This project has in this area and has been evaluated in treating depression in a few just begun. The investigators are in the process of acquiring equipment studies. The investigator(s) propose to investigate the efficacy of and the subjects for the study will soon be recruited. tDCS as add on treatment in 60 patients with major depression who will be randomized to receive active and sham tDCS. Baseline to 25. Developing training modules to address risk factors for endpoint change in depression rating scores and CGI will be used to NCDs. Investigator: Dr. Pratima Murthy (Funding by WHO assess the efficacy. Country Office)
22. Five-year course of first episode mania: A retrospective chart This project aimed at developing and testing training modules review. Investigator: Dr. Muralidharan K for medical officers, counselors and community health workers in identifying and remediating behavioural/psychological risk factors Most guidelines across the world give us information on treatment contributing to NCDs such as tobacco use, alcohol use, unhealthy of a manic episode occurring in the course of established BD-I. Not diet, physical inactivity and stress. Activities included a preliminary much information is available on the course of BD-I following a first meeting of experts in Bengaluru, followed by development and field manic episode. Clinical experience tells us that many patients who have testing of the manuals and review by both external experts and an a FEM may not have another mood episode. Hence the duration of expert group meeting jointly organized by the WHO country treatment and prophylaxis following FEM is always a clinical dilemma. office, Ministry of Health and Family Welfare, Govt. of India and There is a need to study the course of BD following a FEM. Further, NIMHANS at New Delhi. given the paucity of Indian literature on the course of BD-I, following a first episode of mania, the investigators propose to do a chart review 26. Diabetes, hypertension, dyslipidemia and its of patients who have been diagnosed with FEM and study their course biomarkers among patients with alcohol dependence. over five years including socio-demographic details, treatment details, Investigator: Dr. Prabhat Kumar Chand family history, co-morbidities as well as follow-up. This study would help to compare the course of FEM in Indian vs. Western settings, 27. Finding genes that predict alcoholism risk in the Indian particularly the type of episodes, as well as to compare the course of population. Investigator: Dr. Prathima Murthy (Funding by BD-I in patients presenting with first episode of depression vs. mania. ICMR)
23. Clinical, cognitive and neuroimaging correlates of 28. Functional MRI: a diagnostic tool for amnestic minimal apolipoprotien E (APOE) genotype in elderly with late cognitive impairment and early Alzheimer’s dementia.
National Institute of Mental Health and Neuro Sciences 209| Annual Report 2014-15
Investigators: Dr. Srikala Bharath, Dr. John P John, Dr. 32. Project NIMHANS ECHO: Virtual knowledge network in Keshav Kumar, Dr. Jitender Saini (Funding by DST) addiction mental health. Investigators: Dr. Prabhat Chand, Dr. Arun K, Dr. Pratima Murthy, Dr. Vivek Benegal, Dr. About 3457 elderly subjects have been screened from April 2014 till Deepak, Dr. Vivek Gupta, Mr. Lakshmanan, Mrs. Lakshmi March 2015, out of a total of 9122 elderly since July 2012. A total of 75 (NIMHANS Intramural Funding) probable cases were evaluated in detail. Those meeting the inclusion and exclusion criteria take recruited and NIMHANS neuropsychology The objective of the study is to increase the skilled capacity in the area battery for elderly (NNB-E)was administered for about 40 patients of mental health by using cost-effective digital technology and make the (AD and MCI) and 20 controls MRI acquisitions performed for 34 best treatment available in the community. The ongoing weekly VKN Subjects (13 mild Alzheimer’s Dementia patients and 21 Amnestic NIMHANS ECHO teleHealth session, a collaboration with Project MCI patients) and 11 cognitively healthy controls using Siemens-3T- ECHO USA consists of components of both case based learning MRI scanner for structural and functional connectivity. i.e. case presentation and didactic sessions by experts. In this weekly training, the aim is to develop a learning loop and a knowledge-sharing The resting state functional connectivity disturbances with marked network which will create in-depth knowledge, skills and self-efficacy volumetric changes were noted in patients with MCI even before among health care practitioners. This guided practice help to decrease there were detectable micro-structural white matter integrity changes. in disparity in the standard of treatment care in our country. The partner Functional hyper connectivity in the EN might reflect the attempts health professionals also present cases. This live (Synchronous) session by the brain to compensate for the functional hypo connectivity in are integrated with an e-learning module certification for participants. the DMN as well as the structural changes in the medial temporal regions. These network based rsFC aberrations have potential utility as neuroimaging biomarkers of aMCI. In mild Alzheimer’s disease (AD), a link exists between resting state functional connectivity and executive network and executive performance (assessed by Verbal Fluency Task) indicating resting state network changes could be reliable biomarkers of minimal cognitive impairment and early AD.
29. An investigation into the patterns of out-patients follow up treatment and the influencing factors for follow up among patients with severe mental illness at NIMHANS: A mixed method study. Investigators: Dr. V Senthil Kumar Reddi, Dr. Kavita Jangam, Dr. Sanjeev Jain, Dr. Jagadisha Theertahalli (NIMHANS Intramural Funding) Impact of Virtual knowledge network
Consistent follow up care and treatment is essential to ensure retention of gains via treatment and prevention of relapse in severe 33. Development of a Partner Focused Intervention for Alcohol mental illness. Each relapse is associated with higher morbidity and Dependence and Assessment of Impact on Couples’ duration of hospital stay as well as loss of economic contribution Outcome. A Pilot Study. Investigators: Dr. Pratima Murthy and functionality of an individual. Identifying patterns of follow up P, Dr. Prabha Chandra, Dr. Vivek Benegal, Dr. Prabhat treatment and factors contributing to the same would be essential to Chand, Dr. Dhanasekara Pandian, Dr. Thennarasu K enhance quality of care and ensure stable recovery. (Funding by ICMR)
30. Regional Technical Training Centre (RRTC) on Opioid This pilot study was conceptualized to develop a needs –based Use Disorders. Investigators: Dr. Prabhat Chand, Dr. Arun intervention of women partners of men with alcohol dependence. The K (Funding by Global Fund Against AIDS, TB, Malaria study was conceptualized in four phases. In the first phase, needs of Round 9) the women were assessed through secondary data review and focus group discussions. These findings were substantiated through in- 31. Comparative efficacy between baclofen and diazepam in depth interviews with women partners in the second phase. In the patients experiencing uncomplicated alcohol withdrawal. third phase, an intervention was evolved and this was tested out in Investigator: Dr. Prabhat Chand (Funding by ICONs the fourth phase in a case-control design. In both groups, the men’s Pharmaceutical) drinking outcomes at three months were comparable. However,
210 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 women partners who received the tailored intervention showed significantly greater improvement in life satisfaction, self-concept, Schizophrenia is a severe mental illness with significant anatomical improved symptoms of anxiety and depression, and more perceived disruption in white matter integrity. The findings of the present life satisfaction, social support and better coping. study with diffusion tensor imaging for white matter abnormalities and measurement of serum S100B levels suggestive of altered Th2/ The intervention manuals in English and Kannada for women Th1 immune response indicated that white matter abnormalities were partners of men with alcohol dependence based on these evidence- minimal in recent-onset schizophrenia and elevated serum S100B based findings were brought out. levels could be correlated with chronicity of the illness.
37. Role of copper in Alzheimer’s dementia- a controlled study. Dr. Siddhesh S Shere. Guides: Dr. Srikala Bharath, Dr. Sarada Subramanian, Dr. Meera Purushottam
Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer’s disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration.
Intervention manuals for women partners of men with alcohol dependence The findings showed no significant difference in levels of serum (in English and Kannada) ceruloplasmin between the AD and healthy control groups. However, a near-significant decrease in copper in the AD was observed which is consistent with reduced copper-dependent biochemical activities 34. Parental consanguinity among schizophrenia patients living such as cyt c oxidase (required for energy generation) and SOD (free in a rural community of south India: A clinical and genetic radical scavenger) described in AD. investigation. Investigators: Dr. Jagadisha Thirthalli, Dr. Rita Christopher, Dr. Gangadhar BN, Dr. Naveen Kumar 38. An exploratory study of resting state brain functional C,Mr. Vikas Agarwal, PhD in Psychiatry (Funding by DBT, connectivity and its association with S100B in major New Delhi) depression. Dr. Venkata Lakshmi Narasimha. Guides: Dr. John P John, Dr. Sarada Subramanian The study is aimed at evaluating the extent of parental consanguinity among patients with schizophrenia living in a rural community. It is believed that a dysregulation in brain regions associated with This will be compared with parental consanguinity of the general affect are central in the etiology of major depression (MDD). population in the same community. Parental consanguinity will Imaging with the recent modality i.e., fMRI during resting state be assessed using both family history method and an established in MDD, through this research, may be helpful in understanding genetic method. The latter method would add substantial value to the the pathogenesis. Also this functional disconnectivity can result in former. A total of 160 patients and 270 controls have been recruited. release of many neurotrophic factors which may be neuroprotective. Clinical consanguinity has been assessed for these subjects by using One such compound is S100-B. Calcium binding protein, actively FIGS. SNP typing for 200 SNPS is being carried out by using the secreted from astrocytes, indicates astrocyte activation. Measuring VeraCode GoldenGate assays. Parental consanguinity will be assessed this compound at peripheral level could reflect the functional by calculating the inbreeding coefficient. This study has potential to disconnectivity. yield novel clues to the genetic etiology of schizophrenia. 39. Insulin resistance in Alzheimer’s dementia. Dr. Sreelakshmi 35. Maternal mental health promotion- Efficacy of training Thankappan. Guides: Dr. Srikala Bharath, Dr. Sarada programme among ANMs (Project-1). Investigators: Dr. Subramanian, Dr. Preeti Sinha, Dr. Meera Purushottam Prabha Chandra, Dr. Ramachandra, Dr. Geetha Desai (Funding by ICMR) Disturbance in the insulin signalling pathways such as insulin resistance is considered as one of the risk factors for chronic conditions like 36. An exploratory study of the link between white matter diabetes and Alzheimer’s dementia. The prevalence of diabetes and integrity and serum levels of S100-B, a peripheral biomarker other metabolic condition are very high in India. This proposed study of neuronal integrity in schizophrenia. Dr. Nitin Ambekar. aims at analyzing the role of insulin and other metabolic parameters in Guides: Dr. John P. John, Dr. Sarada Subramanian AD. The study proposes to find the relation between insulin resistance
National Institute of Mental Health and Neuro Sciences 211| Annual Report 2014-15 and Alzheimer’s dementia and if it is found to be a risk factor, lifestyle study would help in the process of understanding rehabilitation modification can be implemented to reduce the risk of AD. needs in persons with psychiatric disorders and factors influencing rehabilitation in our setup. Services offered at NIMHANS can be 40. Mysore Government Mental Hospital: Medical and Social tuned to address felt needs and barriers interfering with successful History in Early 20th Century. Ms. Sarah Ghani. Guides: rehabilitation. The experience can help in making policies and Dr. P Murthy, Dr. A Sarin, Dr. S Jain (Funding by Wellcome programs which can be used across the country. This will facilitate project) reintegration of patients with psychiatric disability into mainstream society. The thesis explores the history of the Mysore Government Mental Hospital (MGMH), now NIMHANS. It will trace clinical diagnosis, 2. Explanatory models of mental illness among caregivers of treatments as well as medical conditions and social demographics of mentally ill referred to rehabilitation services. Investigators: patients at the MGMH, which was a mental hospital under native Dr. Poornima Bhola, Dr. Hesi Herbert, Dr. Devvarta Kumar, rule. It will explore pattern of clinical services at the MGMH before Dr. Sailaxmi Gandhi, Dr. SK Chaturvedi it shifted to its current campus and how that impacted services and orientation of the new mental hospital. The research project will look 3. Care recipient of persons receiving psychiatric rehabilitation into archival records, annual registers and case records (available from services. Investigators: Dr. Sailaxmi Gandhi, Dr. Chaturvedi the year 1923, around 5000). SK, Dr. Jagadisha T, Dr. PoornimaBhola, Dr. Devvarta Kumar, Dr. Sivakumar T, Dr. Nirmala BP, Dr. Geetha Desai, 41. Madness, Psychiatry and Society: A Study in Psychiatric Dr. Naveen CK Institutions and Popular Response to Insanity in India, 1858- 1947. Mr. Pradipto Roy. Guides: Dr. S Jain, Dr. P Murthy, SK Persons recovering from mental illness attend psychiatric rehabilitation Deuri (Funding by Wellcome project) services at NIMHANS. They receive an array of services planned to meet the needs of the individuals as they recover. A care recipient The study explores the trajectories of psychiatry in the India, exploring satisfaction scale was prepared and validated by the PRS team. Inter- its genesis and subsequent development in a pre-independent scenario, rater reliability values were established. The tool consisted of 33 items from mid-nineteenth to mid-twentieth centuries. It examines the and six domains in the area of patient intake, information/guidance impact of establishment of asylums in India, beginning in 1745 at taken, health personnel, job placements, changes in the patient and Bombay, particularly in changing perceptions about insanity. It brings family/self-perception of improvement in the patient with a VAS. An together ideas of health, illness behaviour and healthcare measures in initial pilot study with 20 subjects showed very high level of satisfaction administrative and clinical accounts of mental illness and community in all domains and high satisfaction in the area of job/home based concepts and approaches to dealing with mental health problems. The job placement and patient functioning. Satisfaction was higher in thesis will be a qualitative and descriptive study in historical methods. males than females (t=2.226, p=0.039). This tool was used for data collection about consumers’ satisfaction at the time of discharge. The results would help the psychiatric rehabilitation services in planning Psychiatric Rehabilitation and meeting consumers’ needs and satisfaction.
1. A naturalistic study of clinical and socio-demographic 4. Work performance of patients attending psychiatric characteristics of patients attending psychiatric rehabilitation rehabilitation services for rehabilitation. Investigators: Dr. services for rehabilitation. Investigators: Dr. Sivakumar T, Sailaxmi Gandhi, Dr. Chaturvedi SK, Dr. Sivakumar T, Dr. Dr. Chaturvedi SK, Dr. Thirthalli J, Dr. Nirmala BP, Dr. Nirmala BP Bhola P, Dr. Desai G, Dr. Gandhi S, Kumar CN, Waghmare A, Udgiri S. Persons recovering from schizophrenia attend psychiatric rehabilitation services at NIMHANS. Engaging in work impacts on Assessment of factors affecting psychiatric rehabilitation is necessary to social, occupational and symptomatic functioning, which contributes plan services and frame policies conducive to recovery of persons with to global work performance. Patients would be assessed at the initial psychiatric disorders. There is a paucity of studies examining factors point when they attend psychiatric rehabilitation services and at the affecting psychiatric rehabilitation in the Indian setup. NIMHANS endpoint when they leave or get discharged from the psychiatric runs a unique psychiatric rehabilitation services for patients with rehabilitation services. Specific socio-demographic such as age, psychiatric disorders. The investigators would study the clinical gender, etc. and illness variables would also be assessed. Griffiths scale and socio-demographic profile of patients attending psychiatric and the MIRECC Global Assessment of Functioning Scale are the rehabilitation services and factors influencing rehabilitation. The tools used for data collection. The study would help understand the
212 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 effect of engaging in work on social, occupational and symptomatic The main objective of the project is to provide psycho social functioning. interventions for children under care and protection and counseling training for counselors. This particular project is funded by Karnataka 5. Effectiveness of community based rehabilitation for adults State Integrated Child protection Society, Dept. of Women and Child with severe mental disorder based on WHO guidelines Development, Govt. of Karnataka. Through this project psychosocial in a rural area of South India. Dr. JW James. Guides: Dr. interventions are being provided to children from Government Jagadhisha Thirthalli, Dr. Dharitri Ramaprasad, Dr. Naveen Homes and children who come for care and protection through Child Kumar, Dr. Sivakumar T Welfare Committee. Preventive and promotive mental health activities are being carried out in the institute. Children in need of curative People with mental health problems have limited access to support and treatment are being referred to Child and Adolescent Psychiatry health services particularly in low-income countries and historically OPD. Supervision and handholding support for counselors in Govt. have also been excluded from community based rehabilitation Children Homes are also being provided. programmes. The published Indian studies have implemented CBR as stand-alone projects for psychiatric disorders, with help of 3. A study on psychosocial correlates and problems of caregivers community resources. Such programmes need ongoing funding and of persons living with cancer. Investigator: Dr. Thirumoorthy supervision. The current study aims to look at the effectiveness of (Funding by ICSSR, New Delhi) community based rehabilitation for adults with severe mental disorder by integrating their care with that of other disabilities, utilizing the 4. Training manual on Reproductive Health Adolescence existing governmental and nongovernmental resources as per the Sexuality and Gender Equality to capacitate social work WHO guidelines. trainees in India. Investigators: Dr. Md. Ameer Hamza, Dr. R Parthasarathy, Dr. N Janardhana (Funding by ICMR) Psychiatric Social Work The training manual was developed in consultation with social work 1. Development of counselling manual and capacity building educators, experts in the area of health, sexuality and reproductive for the counsellors dealing with relationship issues among health. As part of the field testing, 90 postgraduate students of FSWs. Investigators: Dr. N. Janardhana, Dr. N Krishna Social Work were trained. Pre and post assessment was done to test Reddy, Dr. Md. Ameer Hamza, Dr. Jayshree Ramakrishna the efficacy of the manual. The field testing helped the authors to (Funding by Karnataka Health Promotion Trust) fine tune the sessions and same was finalized. The draft manual was sent for the review to experienced mental health professionals, and The main aim of the project was to develop a counseling training their comments were also incorporated. A total of 1000 copies of the manual and foster capacity building of counselors dealing with manual were printed and same were circulated among various schools relationship issues of FSWs. The need assessment was carried out with of social work in South India. counselors, staffs of KHPT, and FSWs through interviews and Focus Group Discussions. Based on these findings, the major themes were 5. Development of psychosocial care manual for children and taken for training and manual development. The training programme adolescents infected with HIV/AIDS. Investigators: Dr. and hand holding support for counselors were carried out in Bagalkot MN Vrinda, Dr. Subbukrishna, Dr. Jayashree Ramkrishna and Bijapur districts. In the pilot phase of first six months the manual (Funding by ICSSR) was drafted and field tested in the later stage. Nearly 18 counsellors were trained and provided handholding support in the field. The draft The research project aims at developing and standardizing manual was given to the experts in the field for review. The necessary comprehensive psychosocial care manual for children and adolescents modifications were made based on the reviewers’ comments. The final infected with HIV/AIDS.As part of the project, need assessment will manual was given to the funding agency for further editing and printing. be carried out in order to understand the issues of them from their perspective with a) children and adolescents infected with HIV/AIDS 2. Psychosocial interventions for children in difficult b) parents and caregivers of children with HIV/AIDS; c) specialists circumstances under care and protection of child welfare of ART centers (medical professionals, pediatricians, nodal officers, committee Bangalore. Investigator: Dr. N Janardhana, Dr. medical officers, etc.) and policy makers at government levels and d) BP Nirmala, Dr. N Krishna Reddy, Dr. Md. Ameer Hamza, counselors, community care providers, and NGO staffs. Based on the Dr. H Uma, Dr. Roopesh, Dr. John Vijaya Sagar (Funding by need assessment and in triangulation with existing research literatures Dept. of Women and Child Development, Government of in psychosocial care, a comprehensive Psychosocial Care Manual Karnataka) will be developed in English. The manual will be given to experts
National Institute of Mental Health and Neuro Sciences 213| Annual Report 2014-15 for validation and later it will be field tested with counselors and women with psychiatric disorder have reported significantly higher community care providers who work with children and adolescents incidences of all types of abuse as compared to healthy women. infected with HIV/AIDS at NIMHANS. 12. Sensitization workshop for Government Primary School 6. Testing of self-help yoga manual for Indian caregivers Teachers on Child Abuse and Neglect: Development of of persons with schizophrenia living in the community. manual for teachers on child abuse and neglect. Investigators: Investigators: Dr. Aarti Ranganadhan, Dr. Md. Ameer Dr. Kavita V Jangam, Dr. K. Sekar (Funding by Ramachandra Hamza (Funding by ICMR) N Murthy Foundation)
7. Psychosocial care for students of Govt. ITI. Investigators: The project is in last phase of its completion. Sensitization program of Dr. E Aravind Raj, Dr. Ameer Hamza, Dr. D Muralidhar government teachers have been conducted and based on that manual (Funding by RN Moorthy Foundation) for teachers has been prepared. The manual is being subjected to expert comments to further standardize it. 8. Capacity building and counselling training programme for field functionaries of Integrated Child Protection Scheme in 13. Psychosocial management of ageing caregiver burden in Karnataka. Investigators: Dr. N Janardhana, Dr. K Sekar, Dr. families of persons with Schizophrenia. Mr. Joseph V Philip. R Parthasarathy, Dr. D Muralidhar, Dr. Shekhar P Seshadri Guides: Dr. R Parthasarathy, Dr. Ahalya Raguram (Funding by Karnataka State Integrated Child Protection Society) The main aim of the study is to assess the utility of psychosocial management for ageing caregiver burden in parents of persons with 9. Capacity building training programme for the newly schizophrenia. A total of 240 patients were screened and intervention recruited JJB and CWC members of the state of Karnataka. programme was carried out with 11 families, out of which seven Investigators: Dr. N Janardhana, Dr. K Sekar, Dr. R families dropped out. Drop-out analysis resulted in revised sampling Parthasarathy, Dr. D Muralidhar, Dr. Shekhar P Seshadri criteria. Two families completed the post-assessment, while the other (Funding by Karnataka State Integrated Child Protection two did not. Families that fit into the inclusion and exclusion criteria Society) were identified and necessary permission to recruit participants for research was obtained. Intervention was administered to 41 families. 10. Development and standardization of scale to measure psychosocial wellbeing of children. Investigators: Dr. Kavita 14. Development and standardization of strengths based scale V. Jangam, Dr. E Aravind Raj, Dr. K Sekar, Dr. Marimuthu for persons with depression. Ms. Manasi Oza. Guides: Dr. K (Funding by ICSSR) Sekar, Dr. P Marimuthu (NIMHANS Intramural Funding)
The project aims at the development and standardization of a scale to Globally, more than 350 million people have depression, a mental measure psychosocial wellbeing of children which will be applicable disorder that prevents people from functioning well. WHO estimates for children between the age group of 8 to 13 years and can be suggest that depression is common in all regions of the world. A used in varied situations ranging from normal situations to difficult recent study supported by WHO revealed that around 5 per cent of circumstances. The scale will be subjected to varied reliability and the people in the community had depression during the last year. validity measures. There are various psychosocial treatments used by mental health 11. Childhood abuse and self-harm among women hospitalized professionals such as psychiatrists, psychiatric social workers and for psychiatric disorders. Investigators: Dr. Kavita V psychologists for individuals with depression. One of the models of Jangam, Dr. K Sekar, Dr. Muralidharan K, Dr. N Janardhan treatment by social workers that is gaining much deserved popularity (NIMHANS Intramural Funding) is the strengths based approach. This approach has been used by social workers to treat various kinds of mental disorders. The approach Significant findings have been established by the project, which was assumes (as has been discussed in the earlier part of this chapter) completed in June 2014, indicating incidence of childhood abuse that every individual has strengths that need to be tapped into if the (physical/ sexual/ emotional) among women seeking treatment from individual is to be helped. While many social workers, especially in the NIMHANS on inpatient and outpatient basis. The total sample size west, have started using this approach and have been successful, it is for the study was 609 women with psychiatric disorders and 100 also true that there is the lack of a tool that can measure the strengths healthy women as comparison group. Findings have indicated that of persons suffering from depression.
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Thus, this study is one of the first attempts at trying to develop a tool 18. Life experiences, quality of life, well-being and future that may help in tapping the strengths of persons with depression, so strategies of older transgender Individuals. Ms. Alphonsa that the treatment based on the strengths approach may gain more George. Guides: Dr. N Janardhana, Dr. D Muralidhar coherence. This study is thus an attempt to construct a tool that may (Funding by ICMR) help persons with depression and the clinical social worker identify their clients’ strengths and thereby result in effective psychosocial The study aims to find out the life experiences, quality of life, well- treatment. being, and future strategies of transgender individuals who are above 40 years of age and to develop a social work intervention model. 15. Psychiatric social work intervention on expressed emotion, knowledge, attitude and practices among caregivers of This study looks upon the transgender individuals who are 40 years of persons. Mr. Kannappa Shetty. Dr. Janardhana N, Dr. P age and above, whose visibility is meager in the society, nonetheless, Marimuthu whose experiences could be immense. The transgender people earn their living mainly through sex work and beggary during their youth Expressed emotion is a significant feature of the family environment or productive age. Once they grow older or say, become 40 years of that has been found to predict symptom relapse in persons with age or above, they become less productive with regard to sex work. schizophrenia. Majority of the studies have indicated that psychosocial Their means of living then becomes a big question, which will have interventions along with the pharmacotherapy would provide better direct effects on their quality of life and increase their well-being outcome and helps in mainstreaming the persons with illness at the needs. There is also a chance that they would be side lined in their earliest (Hooley & Parker, 2006). Thus, the proposed study aimsto own community, though a few of them becomes the heads or gurus of develop and validating the culturally sensitive psychiatric social work the community. With all these possibilities, this group is generally not (PSW) intervention for the caregivers of persons with schizophrenia visible in the society after a particular age. in reducing high EE and improving their knowledge. The efficacy of the intervention package will be tested with 80 samples and RCT What happens to these people when they grow older? What happens design will be adopted in the study. after they cross their productive age? What is their Quality of life and well-being? What factors led for the acceptance of transgender 16. Efficacy of psychiatric social work intervention as add-on individuals in some families and not in many families? What are the measure in enhancing insight among persons with first varied life experiences of older transgender individuals? How did they episode schizophrenia. Mr. Boban Joseph. Guides: Dr. D cope with the adversities in their life? What are their plans for their Muralidhar, Dr. Shivarama Varambally, Dr. Devvarta Kumar future? These are the research questions that are part of the study.
Improving illness insight is associated with improvement in 19. Efficacy of group intervention module for adolescent social functioning, quality of life, internalized stigma, involuntary girls on self-awareness. Ms. Jasmine Joseph. Guides: Dr. hospitalizations and relapse. An estimated 50 to 80 per cent of the N Janardhana, Dr. HR Nagendra, Chancellor, Swami people with schizophrenia are lacking insight into their illness. Vivekananda Yoga Anusandhana Samsthana (SVYASA) This study is attempting to enhance the levels of insight at the first Bangalore (Funding by ICMR) episode of the illness via a comprehensive brief intervention based on psychiatric social work concepts. Classical experimental design has The aim of the study is to develop a group intervention module been chosen for this study and there will be two groups (intervention for adolescent girls on self-awareness and test its efficacy among and control group) with the sample size of 100. adolescent girls. The outcome variables include self-awareness, self- esteem, coping with stress and emotions. Self is a construct framed 17. Efficacy of treatment adherence enhancement interventions over the period of ones’ development. An adolescent, since faced for persons with Bipolar Affective Disorder. Mr. Ragesh G. with varied internal and external changes during the period, tend to Guides: Dr. Md. Ameer Hamza, Dr. SK Chaturvedi understand oneself in many different levels. Body focused techniques helps one in understanding the subtle changes of the body by bringing Randomised control study design is being used for this nine-month awareness into the physical body frame and can help in enhancing self- follow-up study. A total of 80 samples divided have been divided awareness of an individual. The research focuses for multi-disciplinary into two groups: experimental and treatment as usual group. The intervention for adolescent girls on enhancing their self-awareness. experimental group would be provided a special treatment adherence The qualitative phase of the research is being carried out. In-depth enhancement intervention developed by the researcher. Development interviews were conducted with mental health professionals and yoga of psycho educational handbook is also part of the study. practitioners. The responses were consolidated to identify themes and
National Institute of Mental Health and Neuro Sciences 215| Annual Report 2014-15 sub themes and intervention module was framed based on the derived The aim of this research is to develop a need-based psychosocial themes. Validation of the module and intervention with a follow-up of intervention for siblings of schizophrenia and test its efficacy on six months form the scheduled plans for the research. siblings’ knowledge about schizophrenia, self-stigma, caregiver burden and coping strategies. Intervention and pilot testing have 20. Intensive case management for persons with severe alcohol been completed and the study is in its final phase of the recruitment dependence syndrome – a feasibility study. Mr. Arthur process. Joseph. Guides: Dr. R. Dhanasekara Pandian, Dr. Pratima Murthy (Funding by NIMHANS) 27. Psychosocial issues of renal transplant candidates – a need based intervention. Ms. Patricia Namitha Maria Viego. The aim of this research is to develop a need based psycho social Guides: Dr. Prakashi Rajaram, Dr. Gokulnath, HOD of intervention package and to examine the feasibility of intensive case Nephrology, Vydehi Hospital. management as an adjunct to routine treatment for persons with severe alcohol dependence (i.e. Delirium Tremens), on the patient’s 28. Assessment of psychosocial vulnerability among children addictions severity, motivation, self-efficacy and quality of life. The in internal displacement: development and standardization study is in the initial phase of need assessment in which a total of of an instrument. Ms. Paramita Bhowmick. Guides: Dr. K seven cases have been recruited and the process is ongoing. Sekar, Dr. P Marimuthu (NIMHANS Intramural Funding)
21. Analysis of data was carried out and chapterisation is in Internal displacement has become the most pressing humanitarian progress. Ms. Nagaitlong Mary. Guide: Dr. Md. Ameer and rights issue throughout the world. In India, north-eastern states Hamza are affected by internal displacement since independence and it continues to be a growing problem especially for children. The current 22. Psychosocial therapeutic intervention with parents of study focuses on ethnic violence induced internal displacement children and adolescents referred to family psychiatry in north-eastern state of Assam, Kokrajhar District and how the centre. Ms. Tania Roy. Guides: Dr. A Thirumoorthy, Dr. R complex multiple dimensions of social, political and economic Parthasarathy (Funding by UGC) aspects of such ethnic conflict have impact on the lives of displaced children in their growing years of development. This study aims at 23. Development of psycho-social intervention for suicide developing a statistically valid instrument to measure the dimensions prevention among transgender persons. Mr. Virupaksha. of vulnerability among the displaced children and standardize it over Guides: Dr. D Muralidhar, Dr. Jayashree Ramakrishna a population of N = 700. (Funding by UGC) The current study has adopted a multi-method design with qualitative The study is intended to develop a need-based psycho-social and quantitative methodology. intervention framework for addressing suicidal risk among transgender community. It will evaluate the existing suicide prevention 29. Efficacy of family centered psychiatric social work strategies and help in the process of strengthening them to tackle the interventions for persons with first episode psychosis: A needs. The study will involve the transgender community and the randomized controlled trial. Ms. Udgiri Swarupa. Guides: non-governmental organizations that are actively working for the Dr. BP Nirmala, Dr. Jagadisha community to ensure applicability of the intervention. Schizophrenia is a leading cause of disability across the globe. It 24. Home environment, psychological health and psychosocial ranks among the world’s top 10 causes of disability-adjusted life- competencies of adolescent children of parents with alcohol years. India is home to an estimated 5 million individuals with dependence syndrome. Mr. Muthuraju. Guides: Dr. RDS chronic psychotic disorders. A FEP usually occurs in adolescence/ Pandian, Dr. Vivek Benegal. early adulthood. Three out of 100 people worldwide will experience at least one psychotic episode during their lifetime. The majority 25. Development and evaluation of a psychosocial intervention of individuals with FEP have a poor long-term outcome results in for women with substance dependence. Ms. Reny Thomas. great personal suffering and societal cost. As is the case in other Guides: Dr. R Dhanasekara Pandian, Dr. Pratima Murthy. developing countries, India faces an acute shortage of specialist mental healthcare providers and this presents a significant barrier 26. Efficacy of psychosocial intervention with siblings of against efforts to implement empirically-based interventions.Most persons with schizophrenia. Mr. Amaresha C. Guides: Dr. D clinical and psychosocial deterioration in psychosis occurs within Muralidhar, Dr. DK Subbakrishna. the first five years of the onset of the illness, suggesting that this is
216 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 a critical period of treatment initiation. Thus, pharmacological and Schizophrenia is a debilitating psychiatric disorder with prevalence psychosocial treatment delivered during this critical period has been of .05 to 1 per cent worldwide. About 70 per cent of persons living hypothesized to have a stronger impact than comparable treatment with schizophrenia get married. This study was viewed as critical provided later in the illness. The current study may address the as evidence suggests that there is no specific marital intervention limited number of mental health professionals in India while programme for spouses/ partners of persons living with schizophrenia leveraging comparatively richer family supports. (PLWS). Inadequate knowledge about schizophrenia, spousal burden, disturbed communication and sexual functioning might 30. Impact of psychosocial interventions on perceived social lead to separation or divorce in couples of PLWS. But there was support and illness perception of persons with glioblastoma little evidence from India that examined the assessment of marital multiforme. Mr. Birudu Raju. Guides: Dr. N Krishna Reddy, needs, development of marital intervention programme and testing Dr. Paritosh Pandey, Dr. Vani Santosh the efficacy of the intervention programme. Most importantly, Social Workers/Psychiatric Social Workers are largely unprepared to meet Glioblastoma Multiforme (GBM) is the most frequent tumor among the marital challenges of couples with PLWs in India. all primary intracranial tumors with a frequency about 15%-50%. It can be seen in all age groups; however, patients are generally over 50 33. Impact of social group work intervention in caregivers of years of age. Providing treatment for GBM patients is not just aimed persons with first episode psychosis. Mr. Anvar Sadath. at controlling symptoms of the disease. It also aims at extending and Guides: Dr. D Muralidhar, Dr. Shivarama Varambally improving the quality of the patients’ life. However, often, psychosocial impact of brain cancer patients (GBM) and life limiting disease The evidence for the effectiveness of family interventions in conditions may not be noticed adequately and dealt with during the chronic psychosis is well established through systematic reviews and admission period, thereby giving rise to a more complex situation meta-analysis of outcome studies. Such reviews report that family than the disease condition itself for these patients in India. The intervention might reduce the risk of relapse. Hospital readmissions primary brain tumor Glioblastoma (grade IV) have caused a variety and improved compliance with medication, benefits in general social of psychosocial issues on the patient in different phases of illness. functioning and reduction in levels of expressed emotion within the The effects of tumor existence, surgery, radiation, chemotherapy family and family burden have been documented. These studies are and adjuvant medication are combined in creating neuro-cognitive mostly composed of individual focused family interventions, and complications for Glioblastoma patients. The psychosocial support show inconsistent outcome results. Group intervention has not been needs of patients and their caregivers of Glioblastoma are likely to evaluated with caregivers of first episode psychosis. Moreover, earlier be greater because there is little time to adjust or adapt to the disease. family interventions were not based on the identified needs of the caregivers. In this scenario, the researcher conducted a need-based 31. Psychosocial needs, distress, social support, quality of life social group work intervention for the caregivers of patients with and functionality of newly diagnosed malignant brain tumor FEP patients. Mr. Birudu Raju. Guides: Dr. N Krishna Reddy, Dr. . Vani Santosh, Dr. Paritosh Pandey (Funding by DBT) 34. Psychosocial profile of adolescent girls in romantic relationship under care and protection of child welfare The present study assessed the psychosocial needs and issues of committee. Dr. MB Manjula. Guides: Dr. BP Nirmala, Dr. N patients with Glioblastoma to along with the impact of psychosocial Janardhana interventions on feasibility basis. The study helped to adapt an integrative therapy model which included supportive therapy, The aim of the research project is to study the psycho social profile education and pain management, enhancing social support, coping of adolescent girls in romantic relationship under care and protection skills and behavioural techniques. The psychosocial interventions have of CWC. It is also intended to develop a theoretical framework for been found to be beneficial in increasing supportive needs, coping intervention of adolescent girls in romantic relationship under care skills, changing unhealthy illness perceptions, increasing knowledge and protection. levels and adjusting with treatment conditions, reducing their psychological distress, retaining to continuity of care and increased Descriptive research design with mixed methods of both quantitative preparedness levels to face the adverse situations in the near future. and qualitative will be adopted for the study. In the quantitative phase, psycho social profile of the participants will be studied with 32. Efficacy of marital intervention programme for couples with regard to their attachment styles, temperament, attitudes and values a spouse having schizophrenia – A randomized controlled on sexuality, family functioning. Qualitative part of the study will trial. Mr. Dharma Reddy Pashapu. Guides: Dr. Md. Ameer focus on adolescent girl’s perception about romantic relationship, Hamza, Dr. Prabha S Chandra, Dr. P Marimuthu attribution, expectations, cognitive and emotional processes of
National Institute of Mental Health and Neuro Sciences 217| Annual Report 2014-15 romantic relationship and their views on factors associated with care psychological and social determinants. These negative health related and protection issues. behaviours are going to determine their health in the future. So there is an urgent need to address the negative health related behaviours and Research studies on adolescent romantic relationships showed that teach adolescents about positive health related behaviours and healthy they have significant impact at individual, family level and especially on life style. The research aims to develop an intervention package which mental health of adolescents. Hence, the study provides understanding target health related behaviours such as alcohol abuse, smoking, about psycho social aspects adolescent girls in romantic involvement physical health and physical exercises and eating habits of adolescents. with regard to their perspectives about romantic relationship. This Health related cognitions such as knowledge, self-efficacy, locus of helps in developing culture specific explanatory model of romantic control and intention are targeted through the package. relationships. The present study has implications for both therapeutic interventions for this group and further research in the area. 38. Video feedback intervention to enhance mother-infant interaction: A feasibility study. Ms. Baseema K. Guides: Dr. 35. Feasibility of Psychosocial intervention for siblings of Md. Ameer Hamza, Dr. Prabha S Chandra, (NIMHANS children with Autism Spectrum Disorders. Dr. Sudha Intramural Funding) Thomas. Guides: Dr. N Krishna Reddy, Dr. John Vijay Sagar. Infant-caregiver interaction is of crucial importance in child’s The investigators have studied the psychosocial needs of siblings of development. Interaction with the caregivers builds up the social children with autism spectrum disorder. A need based psychosocial context through which the child encounters the world around intervention module for siblings of ASD has been developed to him/her. If the relationship between the infant and the caregiver evaluate the feasibility of psycho-social intervention in improving fails to be appropriately established, the development of the their knowledge, coping and adjustment, sibling relationship and child is compromised, no matter what the reason for the failure reduction of their behavioural problems. The variables of knowledge, is. There is evidence that the timing, duration, and intensity of a sibling relationship, behaviour problems, coping and adjustment have maternal illness are one of the major factors influencing poor child been measured quantitatively as part of the analysis. neurodevelopmental outcomes. Evidence suggests that as maternal mood recovers, the quality of relationship between mother and infant 36. Effectiveness of student enrichment programme for rural does not automatically improve, parenting stress may remain elevated school children by teachers. Mr. Patrick Jude. Guides: Dr. K. and attachment may remain poor. The current study attempts to find Sekar, Dr. E Aravind Raj out the feasibility of video feedback intervention to enhance mother- infant interaction in the in-patient care of the hospital. This would The research aims at building the capacity of teachers in understanding help to create an understanding about the need for interventions for the components of enrichment of students which includes the mothers with psychiatric illnesses. importance of physical health, principles of mental health, study habits, exam preparation and role of parents and teachers and eventually 39. A study on psychosocial impact and coping patterns among take the same to the students of classes V to VII through two weekly the family caregivers of persons with spinal cord injury. sessions (44 sessions each 45 to 60 minutes spanning 20 to 25 days Ms. Dhanya P. Guides: Dr. N Krishna Reddy, Dr. Nupur P based on the feasibility of the school timetable) involving simple (NIMHANS Intramural Funding) activities like free listing, group discussion, quiz, role plays and so on. The capacity building of the teachers would span around 3-5 days and Spinal Cord Injury (SCI) is truly a devastating injury with profound this is done mainly to ensure the sustainability of the intervention in consequences to the individual, his/her family and society where the the school environment. To establish the effectiveness, the knowledge severity is not only in physical health but also social and psychological of the teachers and the students regarding the programme will be ramifications for the injured person as well as family. It also brings evaluated using structured tools before and after the intervention and tremendous changes n day to day life among loved ones and spouses three months post intervention. who becomes caregivers for persons with SCI. The new tasks associated with caring for an SCI patient are uneven amongst carers, thereby 37. School based intervention for healthy life style of adolescents. causing increased levels of depression, stress and anxiety, inability Mr. Soyuz John. Guides: Dr. R Dhanasekara Pandian, Dr. E to cope with caregiving tasks, physical and emotional disturbances, Aravind Raj (NIMHANS Intramural Funding) and conflicts among family interpersonal relationships and family cohesion which is turn has a toll on the quality of life of the caregivers. Young population especially adolescents are vulnerable to many This warrants the necessity of appropriate and timely psychosocial health affecting negative behaviours such as alcohol, smoking, assessment and interventions for the caregivers that would improve physical inactivity and unhealthy food habit due to their biological, their quality associated life years (QALYs).
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40. A study on the self-concept and academic efficacy of children thought to have approximately 90million people with varying degrees with learning disability and their siblings. Ms. Joice Steffi of learning disabilities and an average class in schools has about five Y. Guides: Dr. N Janardhana (NIMHANS Intramural students with learning disabilities. When special needs of children with Funding) learning disabilities are not met, it will bring scholastic backwardness and related psychosocial problems. Teachers can play a vital role in Learning disability means a disorder in one or more of the basic helping such children through starting with early identification. The psychological processes involved in understanding or in using aim of the current research was to study the awareness of primary language, spoken or written that may manifest itself in an imperfect school teachers in identifying children with learning disabilities. The ability to listen, think, speak, read, write, spell or to do mathematical study followed descriptive research design. calculations, including conditions such as perceptual disabilities, brain injury, minimal brain dysfunction, dyslexia and developmental aphasia. 44. A study on stress, burden, social support and the desire The term does not include learning problems that are primarily the to institutionalization among caregivers of persons result of visual, hearing or motor disabilities, of mental retardation, with dementia. Ms. Sherin Yohannan. Guides: Dr. A of emotional disturbance, or of environmental cultural or economic Thirumoorthy, Dr. Preeti Sinha (NIMHANS Intramural disadvantage. Funding)
41. Violence against women with bipolar affective disorder Demographic trends regarding the issue of aging underscore the fact (BPAD). Ms. Shabana Aboobaker. Guides: Dr. Kavita that both current situations and future trends directly concern all of Jangam, Dr. Muralidharan K (Funding by Maulana Azad us. Dementia is the term used to describe the symptoms of a large Fellowship) group of illnesses which cause a progressive decline in a person’s functioning. It is a broad term used to describe a loss of memory, Women with mental illness are significantly more likely to be victims intellect, rationality, social skills and physical functioning. Dementia of violent crime than other women; little research exists that focuses is seriously disabling for those who have it and is often devastating exclusively on the relationship between victimization and mental for their caregivers and families. Improving the awareness and illness in women. Out of 70 respondents, majority of them are married. understanding of dementia across all levels of society is needed Most common violence experienced by the respondents had moderate to decrease discrimination and to improve the quality of life by quality of life. There was negative correlation between experience of reducing stress/ burden and increasing the social support for people violence and quality of life the respondents. Violence is common in with dementia and their care givers. women with bipolar disorder target. 45. A comparative study on disability, social functioning and 42. Barriers to access and utilization of mental health care quality of life of married and unmarried women living with services among women. Ms. Shari, TM. Guide: Dr. BP schizophrenia. Ms. Suhara RH. Guides: Dr. Md. Ameer Nirmala (NIMHANS Intramural Funding) Hamza (NIMHANS Intramural Funding)
Significant proportion of patients find psychiatric services as the last The question of care and wellbeing of women with schizophrenia is resort after having consultations with many different types of non- always a challenge for the aged parents when they are not married and psychiatric care providers, including faith healers. In this process, a lot dependent on their parents. These challenges raise the questions of of crucial time is lost, which could have relevance to better prognosis, the benefits of marriage and procreation for these groups. The current as early recognition and management are of utmost importance in study attempts to answer the following questions: If women with psychiatry. This has increased the importance of various social and Schizophrenia are supported well by their spouse, can it influence the cultural factors which determine the help seeking behavior and disability, quality of life and social functioning in them? And is there pathway of psychiatric care. The study aims to study the barriers to difference in their functioning compared to the unmarried women access and utilization of mental health care services among women living with Schizophrenia. diagnosed with depression. 46. Psychosocial impact of repatriation among internally 43. A study on awareness of primary school teachers in identifying displaced persons in North East India. Ms. Tecie Lalduhzuali. children with learning disabilities. Ms. Shari M. Guide: Dr. Guide: Dr. D Muralidhar (Funding by UGC) Vranda MN (Funding by NIMHANS) Internally displaced persons are those individuals who are forced to Learning disorders are one of the childhood mental health issues that flee their homes as a result of armed conflict, ethnic or communal need special attention in primary, secondary and tertiary levels. India is violence, human rights violations, etc. Internally displaced persons are
National Institute of Mental Health and Neuro Sciences 219| Annual Report 2014-15 prone to psychological problems and diseases. They have to struggle The present study highlighted that the transgender people are deprived much for livelihood and are highly vulnerable to stressful events. The of many of the rights and privileges which genders—male and aim of the study is to see how repatriation affects the psychosocial female—enjoy as the citizens of the country. They are also deprived of aspect of internally displaced persons. social and cultural participation. As the transgender people have very limited employment opportunities, sex work and begging are the only 47. Development of an illustrated psycho-educational material recourses for their livelihood. They are often treated as a legal non- for caregivers of persons with schizophrenia. Mr. Victor entity and not allowed to identify themselves on official documents. Alexander. Guides: Dr. K Sekar, Dr. Jayashree Ramakrishna Due to varied psychosocial problems, transgender people had lower (NIMHANS Intramural Funding) levels of subjective well-being.
It is estimated that 6-7 per cent of the population suffers from mental 49. Experiences and needs of adolescent children living with a disorders. One in four families is likely to have at least one member parent with mental illness. Dr. Divya Ballal. Guides: Dr. N with a behavioural or mental disorder (WHO 2001). Schizophrenia Janardhana, Dr. Jayashree Ramakrishna (Funding by UGC) ranks among the top 10 causes of disability in developed countries worldwide. According to National Institute of Mental Health, Families affected by parental mental illness are among the most the prevalence rate for schizophrenia is approximately 1.1 % of the vulnerable in our community. Children within these families are population over the age of 18 or, in other words, at any one time especially vulnerable with increased risks genetically, psychologically as many as 51 million people worldwide suffer from schizophrenia. and environmentally (Beardslee, Versage & Gladstone, 1998). Yet, the For the affected persons, these families not only provide physical problems of children across the world, who live with a parent with and emotional support, but also bear the negative impact of stigma mental illness, continue to remain largely invisible. and discrimination. Most of them (>90%) remain un-treated. Poor awareness about symptoms of mental illness, myths and stigma related This study aims to investigate the subjective experiences and needs to it, lack of knowledge on the treatment availability and potential of adolescent children, aged 15-19 years, living with a parent with benefits of seeking treatment are important causes for the high a psychotic illness. The study will adopt a qualitative methodology, treatment gap. specifically a grounded theory method. In-depth interviews will be conducted with study participants, based on an interview guide There is no scientifically developed, culturally appropriate and developed for the study; interviews will be transcribed and analyzed simple-to-understand illustrated psychoeducational material which under a grounded theory framework. In addition, a few quantitative could be directly used by caregivers of persons with Schizophrenia. measures (family functioning, coping and subjective well-being) will The current research uses the theories of health education and be studied and further triangulated with the qualitative data. Mental research techniques to develop a scientific mental health educational health professionals, with experience of working with this population, material. will also be interviewed to triangulate the needs of this population.
48. Subjective wellbeing among transgender people in The proposed outcome of the study is a theoretical perspective Bengaluru. Mr. Nithyananda S. Guide: Dr. D Muralidhar. to understand the subjective experiences of adolescent children living with a parent with mental illness, a checklist to identify their Transgender persons in India are often marginalized, stigmatized and experiences, and a theoretical intervention, based on the identified harassed by their own parents, family members and friends and face needs. societal discrimination. According to a recent study, the transgender communities are among the groups at highest risk for HIV and STIs 50. Brief psychosocial intervention for youth with problematic across the world. These factors have made the governments, national internet use - A feasibility study. Mr. Prasad Kannekanti. and international organizations to focus their attention on transgender Guides: Dr. Md. Ameer Hamza, Dr. Manoj Kumar Sharma people. (Funding by NIMHANS)
The study aims at understanding the level of subjective wellbeing Internet has become inevitable and integral part of modern life of many of transgender communities in Bengaluru. The study adopted as it facilitates business, entertainment, communication, education descriptive research design. The researcher recruited the subjects in the contemporary world. While most people agree that internet for the study using consecutive sampling method. To measure the is a productive tool and beneficial to majority of the users, still its socio-demographic details, a semi structured interview schedule was excessive use leads to significant negative consequences. Internet use adopted and to measure the level of subjective wellbeing, subjective and associated mental health issues (anxiety, depression, etc.) among wellbeing inventory was used. users over a period of time highlighted the need of intervention for
220 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 problematic use. So far, at least in India, no structured intervention Haragadde, Jigani, Mahanthalingapura and Indlavadi will be studies have been carried out to promote healthy usage of internet and selected for the study as experimental group. The control group will target specifically problematic or harmful internet users. The present be selected based on the proximity, geographical similarities and the study is an attempt in the direction of developing and exploring the number of health workers from the Bangalore South taluk. The study feasibility of providing a viable option in the form of cost-effective would use adapted version of geriatric mental health literacy survey, and time efficient brief psycho social interventions for youth with follow-up assessment questionnaire along with socio demographic problematic internet use. The same can further be utilized by various data sheet for data collection. The content of the geriatric mental other stakeholders. health literacy program would focus on training the community health workers on identifying the common geriatric mental health 51. Psychosocial factors associated with family accommodation problems, how to identify the risk population, what are the types among couples with a spouse having obsessive compulsive of treatment required and available, what are the strategies they disorder. Mr. Srinivas. Guides: Dr. Md. Ameer Hamza, Dr. can impart to the community to prevent geriatric mental health A Shyam Sundar (Funding by DBT) problems, also the type of family level interventions which can be carried out at the community level. Obsessive Compulsive Disorder (OCD) is a common mental disorder affecting 2-3per cent of the general population and rated as one among 54. The impact of antenatal psychosocial risk factors on maternal the 10 most disabling medical conditions. Though OCD is typically and mother-infant outcomes. Ms. Supraja, TA. Guides: Dr. considered an individual phenomenon, the affected individual’s Kavita V Jangam, Dr. Prabha S Chandra (Funding by UGC) environment can both impact and be impacted by the illness. The responses of significant people including spouse may play significant The aim of this prospective study is to examine the prevalence of role in the course and outcome of the disorder, quality of life of psychosocial risk factors during pregnancy and to assess its relationship individuals involved and can impair family functioning too. Studies so with postpartum maternal outcomes and mother-infant outcomes. far tried to look at the relationship between one or two psychosocial variables of caregivers in general and family accommodation rather A prospective naturalistic study design will be adopted for this study. than understanding the interplay of these psychosocial variables Assessments would be conducted at two time points – during the 3rd in specific relationship context. The study aims at identifying trimester of the antenatal period and between 12-16 weeks during psychosocial variables influencing family accommodation among the postpartum period. In the antenatal interviews the presence of couples and developing theoretical framework for the intervention to psychosocial risk factors of maternal mood, stress, lack of support, address the same issues. family violence and occurrence of any major life events would be assessed. 52. Social case work amongst persons with depressive disorders – A strengths perspective. Mr. Sudeep Jacob Joseph. Guides: A monthly charting method would be used to retrospectively record Dr. A Thirumoorthy, Dr. K Sekar, Dr. Santosh Loganathan significant occurrences in the personal, familial and social domains (Funding by GFATM, Saksham, Mumbai, CBM, Sama during the interval period between the antenatal and postpartum Foundation, Bangalore) assessments.
53. Development and field testing of geriatric mental health Postpartum interviews would focus on assessing the maternal literacy program for community health workers. Ms. Anila outcomes of mood, maternal self-efficacy, breastfeeding self-efficacy Michael. Guides: Dr. A Thirumoorthy, Dr. N Girish, Dr. PT and mother-infant outcomes namely bonding and infant care. In Sivakumar addition to this a five-minute speech sample about the experience of mothering would be sought from the mother and an objective rating The aim of the study is to develop and study the feasibility of Geriatric would be done using a coding framework. Mental Health Literacy Program for Community Health Workers. The objective of the studies are: to formulate a geriatric mental This study would be able to inform the body of knowledge on the health literacy program for the community health workers; to assess impact of psychosocial risk factors during pregnancy on specific the impact of geriatric mental health program for the community postpartum outcomes. It would also be able to estimate the prevalence health workers and to identify the challenges in implementing the rates of specific psychosocial factors in an indigenous population and geriatric mental health literacy program in the community. Of the bring out socio-culturally relevant findings. five taluks of Bengaluru, Anekal taluk and Bangalore South taluk would be selected as the universe for the study. The four PHCs 55. Psychological impact and coping among college students under the Sakalawara Community Mental Health Centre namely using social networking sites in Bangalore city. Ms. Rupa
National Institute of Mental Health and Neuro Sciences 221| Annual Report 2014-15
Sanadi. Guide: Dr. R Dhanasekara Pandian (NIMHANS role of social support in “buffering” the negative effects of exposure Intramural Funding) to armed conflict on mental health using Multidimensional Scale of Perceived Social Support (MSPSS, Zimet, & Farley, 1988). The The aim of the study is to understand the psychological impact target population consisted of 149 institutionalized orphan children, and coping among college students who are using social networking aged 12-17 (m=15.38) years in Kashmir. sites. Regardless of the type of armed conflict events, the perception In the present study, the researcher recruited 100 college students of threat and fear that a child experiences has a universal (Male= 50, Female=50) in the age group of 18 to 24 years from MS significant negative impact on mental, social, and behavioral well- Ramaiah Arts, Commerce and Science Degree College, Bengaluru. being. The importance of the existence of a significant social support The study reveals that male students tend to use social networking sites in exposed children’s lives is also emphasized. The findings show (SNS) more than female students. Mild level of psychological distress major implications for the development of community-based was found in those who spend more time on SNS. The study showed interventions focusing on improving resilience, mental health and that there are both positive and negative impacts of SNS usages on strengthening social support in the lives of children living in armed college students. Male students tend to use SNS more than female conflict regions of the world. students and are more prone to get addicted and psychologically distressed. However, in terms of adopting coping styles, no significant 58. Efficacy of brief educational training programme on difference was found among the both respondents. teacher’s knowledge and attitude towards reporting child abuse and neglect. Ms. Reshma. Guide: Dr. Kavita V Jangam 56. Group based brief interventions among persons undergoing (NIMHANS Intramural Funding) opioid substitution treatment in Darjeeling: A feasibility study. Ms. Yachna Pradhan. Guide: Dr. R Dhanasekara The aim of the research project was to study the efficacy of brief Pandian (NIMHANS Intramural Funding) educational training programme on teacher’s knowledge and attitude towards child abuse and neglect. The use and consumption of alcohol and drugs have been prevalent in the human races since time immemorial. Among these substances, the This study was conducted among school teachers working in urban use of opioids has been existent for six millenniums. It has been in use government primary schools located in south zone of Bangalore study. for pleasure and for treating pain and diseases like asthma, stomach A total of 55 teachers participated in the training program which problems, and headache. The habitual use of opioids then moved aimed at providing training on child abuse and neglect and attitudes onto harmful use and addiction. The development of alkaloids and towards reporting. Results show that there is significant increase in hypothermic syringe aggravated the scenario. Alkaloids like morphine post assessment compared to pre assessment. The checklist shows a and heroin which were developed to cure alcohol and opium addiction significant increase in the knowledge about child abuse and neglect turned out to be more addictive than opium itself. among teachers. The positive experiences and increased knowledge of the teachers will have implications on conducting more training 57. Impact of armed conflict on mental health of institutionalized programs for the teachers on child abuse and neglect and also orphan children in Kashmir. Mr. Fahim Ul Hassan. Guide: understanding the various factors which would influence teachers Dr. K Sekar (Funding by UGC) reporting on these issues.
The study aims to investigate the relationship between exposure to 59. A study on adjustment problems and empathy among armed conflict and terror events on mental health of institutionalized Bachelor of Social Work students. Ms. Vidya. Guide: Dr. R children in Kashmir. The children of Kashmir have been subjected Parthasarathy (NIMHANS Intramural Funding) to exposure from armed conflict and terrorism repeatedly for the last two decades, with no adequate research or interventions aimed at The objectives of the study are to assess the adjustment problems shielding them from the hazards of such exposure to their mental of Bachelor of Social Work students based on gender and class, and and social well-being. assess the empathy among them. Major findings and results of the study include (a) Majority of the girls (59.1%) poorly adjusted than This research studies the relationship between a newly developed boys (b) Second year BSW students (71.1%) are more poorly adjusted scale (STACE, Harel-Fisch et al., 2010) measuring levels of than first and third year BSW background (c) there is negative subjective perceptions of threat/fear due to exposure to armed correlation (r=-0.20, p=0.023) with social adjustment and 7th domain conflict events and its predicting association with five psychosocial of empathy- willingness to contact to others among first, second and and behavioral outcomes covering mental health. It also examines the third year students (d)other than social adjustment domain, health,
222 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 home and emotional domains have positive correlation with overall stimulation. Mr. Nagendra Madan Singh. Guides: Dr. empathy among students(e) there is significant difference in empathy Chittaranjan Andrade, Dr. Jagadisha T (ICMR Fellowship) domain extreme emotional responsiveness and first, second and third year BSW students and first year BSW students have less extreme This study mathematically models heart rate variability as a function emotional responsiveness than second and third year students (f ) of different electrical doses in an animal model of ECT. there is significant difference between male and female students and sympathetic tendency, where male students have more sympathetic 4. A randomized, double blind, sham controlled study of tendency towards clients than females. Overall findings reiterates the transcranial direct current stimulation (tDCS) as an importance of professional social work interventions for students who augmentation intervention for the attenuation of motor experience adjustment problems and the interventions need to focus deficits in patients with acute ischemic stroke. Ms. Ekta on improving the empathy skills among students in their professional Francina Pinto. Guides: Dr. Chittaranjan Andrade, Dr. field. Anupam Gupta, Dr. Girish Kulkarni
This study examines motor, cognitive, and mood outcomes in acute Psychopharmacology and subacute stroke patients treated with transcranial direct current stimulation as an augmentation of treatment as usual. 1. Electroconvulsive seizure induced neuroplasticity. Investigator: Dr. Chittaranjan Andrade (Funding by DBT) Speech Pathology and Audiology 2. Electroconvulsive seizure-induced neuroplasticity changes in the rat brain. Dr. Ravi Prabhakar Hegde. Guides: Dr. 1. Effects of bilingualism on language development in Down’s Chittaranjan Andrade, Dr. BK Chandrasekhar Sagar, Dr syndrome. Investigators: Ms. Bhat A, Dr. Maganti M, Sumantra Chatarji (ICMR fellowship) Dr. Sanjeeva GN, Dr. Bhat M, IGICH, Bangalore, Dr. Shivashankar N, Ms. SS Meera This study examines hippocampal neuroplasticity after single and repeated electroconvulsive shocks in rats which have or have not Children with Down syndrome (DS) are developmentally delayed. been exposed to chronic unpredictable stress as an animal model of Speech in particular develops more slowly in children with DS than depression. in typically developing (TD) children. Due to these difficulties with language acquisition, bilingual parents of children with DS are Neuroplasticity changes have been proposed as mechanism of action frequently advised to use only one language with their child to ease- of electroconvulsive therapy (ECT). Electroconvulsive shocks (ECS) out the development of communication. However, existing literature and antidepressants have shown to induce nerve cell proliferation in does not support the notion that bilingualism is detrimental to the hippocampus, the increase in the number of neurons is correlated linguistic or cognitive development in either DS or TD children. In with the number of ECS administered. ECT is an important fact, the literature concerning bilingualism in DS at all is very sparse. treatment modality for patients with major depression, schizophrenia This study considered children from urban and suburban India, where and mania. In order to obtain maximum effectiveness with minimum bilingual or multilingual exposure is the norm. The language abilities side effects, ECT has to be dosed appropriately. Understanding dose- of monolingual (n = 11) and bilingual (n= 12) children with DS, who dependent neuroplasticity effects of ECS could guide future research were matched for mental age on the Vineland Social Maturity Scale and practice on ECT stimulus dosing. Therefore this study proposes (VSMS), were compared. Monolingual (n = 10) and bilingual (n = 8) to examine dose dependent ECT induced neuroplasticity using an TD controls were also compared. Language abilities were measured animal model. Brain from control and treated group were removed, using the Peabody Picture Vocabulary Test (PPVT) and Assessment fixed in paraformaldehyde and processed for Golgi method. Using of Language Development (ALD), administered in the child’s first this method the dendritic arborisation of both control and treated language. No significant difference was found between language group were analyzed. Hippocampus of the treated group showed abilities of monolingual and bilingual children in both DS and TD many newly formed dendritic sprouts when compared to control groups. This implicates no detrimental effect of bilingualism on group. Numbers of synapse were increased in the high dose and language development. Although the sample size is small, the results repeated ECT treated animals. These increased synapses were found support previous findings and encourage the parents to raise their to be excitatory in nature. children bilingually.
3. Alteration of heart rate variability and cardiac 2. Prevalence and nature of speech disorders in persons on electrophysiological variables in a rodent model of brain atypical antipsychotic drugs. Investigators: Dr. Vandana VP,
National Institute of Mental Health and Neuro Sciences 223| Annual Report 2014-15
Dr. Preeti S, Dr. Jayaram M, Dr. Enderby P (NIMHANS The objectives of the study are to: (i) investigate the extent to which Intramural Funding) partners/caregivers of persons with aphasia find it necessary to be informed, supported and trained by speech and language pathologists Speech production deficits are frequently associated with the use to take care of their patient with aphasia (ii) investigate the extent of psychotropic drugs. There is a lack of well-controlled studies to which partners/caregivers of persons with aphasia perceive their examining antipsychotic medication-related speech outcomes, expectations and needs are fulfilled, and (iii) investigate the perception associated with atypical antipsychotic drugs. The objective of the of speech-language pathologists regarding the importance of present study was to determine the prevalence, nature and type of supporting family members and the extent to which they provide care. speech disorders in patients on atypical antipsychotic drugs in the Questionnaire is being developed – one for the SLPs and one for the psychiatry outpatient department at NIMHANS between the age caretakers of persons with aphasia, following which participants have group of 18 to 60 years. 140 patients on stable regimen of 3 or more to rate it on a 5-point rating scale. months on risperidone (92), olanzapine (28), aripiprazole (14) or clozapine (6) were recruited. Speech was assessed by maximum 5. Articulatory kinematics in patients with amyotrophic lateral phonation duration (MPD) task, s/z ratio, diadochokinesia, sclerosis. Investigators: Dr. BK Yamini, Dr. N Shivashankar, objective acoustic analysis and Frenchay Dysarthria Assessment Dr. A Nalini (Funding by DBT) (FDA). Extrapyramidal symptoms (EPS) was assessed by Simson Angus Scale. The risperidone group differ from other antipsychotics In this study, patients with Amyotrophic Lateral Sclerosis (ALS) of group significantly in s/z ratio, FDA-total and FDA-reflex. The both bulbar onset and limb onset types, speaking the languages of duration of antipsychotic had an impact on maximum fundamental Hindi, Kannada, Telugu and Tamil are recruited. Findings on the frequency (MFF) for males, noise to harmonic ratio (NHR), FDA- articulatory kinematics for these patients on the non-speech tasks reflex, FDA-palate, and FDA-respiratory. Effect of EPS was seen and the speech tasks are compared against matched healthy controls. on almost all sections of FDA, MFF for males and NHR. The The analysis is in progress. A preliminary analysis on the graphic user implication of the same needs to addressed using a prospective study interface for a non-speech task has been presented here. with more refined methodology.
3. Effect of deep brain stimulation on speech of patients with Parkinson’s disease (PD). Investigators: Dr. VP Vandana, Dr. M Jayaram, Dr. Pal PK, Dr. S Dwarakanath, Dr. Y Ravi
Deep brain stimulation (DBS) has been reported to be successful in relieving the core motor symptoms of Parkinson’s disease (PD) and motor fluctuations in the more advanced stages of the disease. However, data on the effects of DBS on speech performance are inconsistent. The aim of the present study is to analyze the pre- and post- DBS speech characteristics of patients with PD using acoustic Figure 1: Sensor 6x graph illustrates the protrusion-retraction rate of and perceptual tasks. Analysis of speech data on seven patients with movement of the tongue, in the anterior- posterior direction, in the healthy pre- and post DBS has been completed. control.
4. Supporting caregivers of persons with aphasia: Comparison of Speech-Language service provision and caregiver demand. Investigators: Dr. VP Vandana, Dr. M Jayaram
Due to improved stroke care, the number of persons surviving a severe stroke is gradually increasing. After the acute phase, stroke survivors often experience severe and persisting impairments like aphasia. After discharge from the hospital, close relatives / care givers provide emotional support and provide practical care in daily life activities. Supporting partners and children is important in the successful Figure 2: Sensor 6x illustrates the rate of protrusion-retraction movement of reintegration of persons with aphasia in society. the tongue, in anterior-posterior direction, in a patient with bulbar onset ALS.
224 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
6. Pragmatics of language in the Broad Autism Phenotype Clinical Neurosciences – A study in the first degree relatives of children with autism spectrum disorders. Ms. SS Meera. Guides: Dr. N 1. Imaging correlates of cognitive impairments in essential Shivashankar, Dr. Satish Chandra Girimaji, Dr. Shekhar P tremors. Dr. Ketaki Swapnil Bhalsing. Guides: Dr. Pramod Sheshadri, Dr. Mariamma Philip. K Pal, Dr. AK Gupta
Findings from this research study have added to cross-cultural 2. A longitudinal study of mild traumatic brain injury: Neuro literature that subtle pragmatic deficits are present in the BAP and imaging and cognitive function outcome. Dr. Ashok that ASD is a heritable condition. It has demonstrated that the BAPQ, Munivenkatappa. Guides: Dr. B Indira Devi, Dr. Dhaval OSC and CCC-2 are sensitive to pick up subtle pragmatic deficits Shukla, Dr. Subbakrishna, Dr. Neeraj U, Dr. Jamuna R in the FDRs. Studies on the BAP are of paramount importance to unravel the pathophysiological basis of the BAP. They can offer 3. Accelerated aging and schizophrenia: Clinical and valuable insights by bringing researchers closer to the genetics and neuroimmunometabolic correlates. Dr. Shiv Kumar. Guides: neurobiological basis underlying ASD. In addition, understanding the Dr. BN Gangadhar, Dr. V Ravi variations present in the first degree relatives of children with ASD may eventually find an active role in clinical interventions. 4. A study of inflammatory markers and heart rate variability in severe head injury. Dr Akhil Deepika K. Guides: Dr. B Indira Devi, Dr. Dhaval P Shukla. Ayurveda 5. Molecular genetic basis of radiation resistance in 1. Clinical evaluation of Brahma Rasayana in the management glioblastoma. Dr. Arun HS. Guides: Dr. SS Sampath , Dr. of “Manasamandata” (Mental Retardation) – an open clinical Vani Santosh, Dr. Arivazhagan A Trial. 6. Study of functional connectivity in early Alzheimer’s 2. Clinical evaluation of a Comprehensive Ayurvedic Dementia. Dr. Rakesh B. Guides: Dr. Srikala Bharath, Dr. intervention in the management of Manodwega (GAD). Sanjeev Jain, Dr. John P John, Dr. Keshav K
3. Clinical evaluation of Aarasvataghrita in the management of 7. Respiratory chain disorders in children – Genotypic, cognitive deficit. phenotypic and functional correlation. Dr. Sonam Kothari. Guides: Dr. PS Bindu, Dr. Gayathri N, Dr. MM Srinivas 4. Pharmacovigillance Programme. Bharath, Dr. K Thangaraj
5. Ayurvedic coded drug (AYUSH MANAS) in the management 8. Adenosine signaling pathway in medically refractory epilepsy of Manasa Mandata (Mental Retardation). due to mesial temporal sclerosis (MTS) lesions. Dr. Vikas Dhiman. Guides: Dr. Sanjib Sinha, Dr. P Satish Chandra, 6. Clinical evaluation of the efficacy of Trayodasanga Guggulu, Dr. A Arivazhagan, Dr. Anita Mahadevan, Dr. Anuranjan Maharashnadi Kwatha and Prasarani Thaila in the Anand. management of Gridhrasi (Sciatica). Investigators: Dr. D Sudhakar, Dr. SK Tiwari 9. Exploring subclinical cerebellar dysfunction in patients with essential tremor, primary writing tremor and writer’s 7. Clinical evaluation of Pathyadi Kwatha in the management cramp by quantitative characterization of ocular movements of Ardhavabhedaka (Migrain). Investigators: PI- Dr. BCS and eye-hand coordination and advanced neuroimaging Rao, Dr. GV Ramana, Dr. HK Gupta. techniques. Dr. Ketan Jhunjhunwala. Guides: Dr. Pramod Kumar Pal, Dr. AK Gupta. 8. Clinical evaluation of Kalyanaka Ghrita in the management of Smriti Dourvalya. Investigators: Dr. GV Ramana, Dr. D 10. Macro and microstructural video-polysomnographic signal Sudhakar, Dr. HK Gupta, Dr. Srinibash Sahoo analysis: sleep and epilepsy Correlation. Dr. Chetan S Nayak.
National Institute of Mental Health and Neuro Sciences 225| Annual Report 2014-15
Guides: Dr. Sanjib Sinha, Dr. AB Taly 17. Effect of cognitive enhancement on impulsivity and response inhibition in heavy social drinkers and offspring 11. Role of renin-angiotensin aldosterone system in cognitive of alcoholics: Event related potential study. Dr. Mrunal B deterioration in patients with cerebral small vessel disease. (Selected for Dual PhD NIMHANS/Liverpool). Guides: Dr. Thomas Gregor Issac. Guides: Dr. SR Chandra, Dr. Rita Dr. Vivek Benegal, Prof. Matt Field, Dr. J Keshav Kumar, Dr. Christopher, Dr. Jamuna, Dr. Mariamma. Paul Christianson
12. Simultaneous EEG FMRI to study phase synchronization 18. Neural oscillations as biomarkers of epileptogenic zone. Dr. and functional connectivity in symptomatic localization Velmurugan. J. Guides: Dr. Sinha S, Dr. Satishchandra P, related epilepsy. Dr. Ganne Chaitanya. Guides: Dr. Satish Prof. Srikantan Nagarajan. Chandra, Dr. Sanjib Sinha, Dr. Rose Dawn Bharath. 19. Identification of biomarkers for psychosis in Parkinson’s 13. Austism spectrum disorders – Role of oxytocin and imaging disease by advanced neuroimaging retinal imaging, analysis. Dr. Sowmyashree. Guides: Dr. Shoba Srinath, Dr. neuropsychological profile and genetic polymorphism studies. Satish Chandra Girimaji, Dr. Rose Dawn Bharath. Dr. Abhishek Lenka. Guides: Dr. Pramod Kumar Pal, Dr. A Shyamsundar, Dr. Jitender Saini, Dr. Shantala Hegde. 14. Vitamin D and immune dysfunction in autism spectrum disorder.Dr. Salah Basheer. Guides: Dr. Satish C Girimaji, 20. Clinical Spectrum and immunobiology of Neuromyelitis Dr. Ravi V optica. Dr. Harikrishna B. Guides: Dr. Satishchandra P, Dr. V Ravi, Dr. Nethravati, Dr. Manjunatha, Dr. Anita Mahadevan 15. Nuclear mitochondrial intergenomic communication disorders - a pheotypic, pathological, biochemical and 21. Exploratory study – In search of retinal neurovascular unit genotypic study.Dr. Shwetha Chiplunkar. Guides: Dr. markers in Alzheimer’s disease. Dr. Ravi Teja. Guides: Dr. PS Bindu, Dr. AB Taly, Dr. Gayathri N, Dr. Meera PS Mathuranath, Dr. Hima Pendharkar Purushottam. 22. Quantitative magnetic resonance imaging of brain in 16. Epigenetic study in alcohol dependence.Dr. Soundarya. duchenne muscular dystrophy. Dr. Preethish. Guides: Dr. Guides: Dr. Pratima Murthy, Dr. Meera Purushottam Nalini A, Dr. Jamuna Rajeshwaran, Dr. Jitender Saini
Number of Research Projects Total Total Amount Involved Total Amount Per Annum Projects (in `) (in `)
A. Newly Sanctioned Projects i) National 29 5,85,19,470.00 2,86,95,718.00 ii) International 02 31 13,54,889.00 13,54,889.00
B. Ongoing Projects i) National 258 61,60,81,519.00 23,59,58,428.00 ii) International 31 7,46,32,234.00 2,58,89,918.00 iii) Training Schemes 02 291 3,40,56,294.00 14,09,483.00
322 78,46,44,406.00 29,33,08,436.00
226 | National Institute of Mental Health and Neuro Sciences Ravi Hegde Publications
International Journals 10. Anand S, Shivashankar R, Ali MK, Kondal D, Binukumar B, Montez-Rath ME, et al. Prevalence of chronic kidney disease in two major Indian cities and projections for associated 1. Abhishekh HA, Kumar NC, Thirthalli J, Chandrashekar H, cardiovascular disease. Kidney Int. 2015. Gangadhar BN, Sathyaprabha TN. Prolonged reaction to mental arithmetic stress in first-degree relatives of schizophrenia 11. Andrade C. The safety of duloxetine during pregnancy and patients. Clin Schizophr Relat Psychoses. 2014; 8(3): 137–42. lactation. J Clin Psychiatry. 2014; 75(12): e1423–7. 2. Abraham AM, Sudhir PM, Philip M, Bantwal G. Illness 12. Andrade C. Antidepressants and testicular cancer: cause versus perceptions and perceived barriers to self-care in patients with association. J Clin Psychiatry. 2014; 75(3): e198–200. type 2 diabetes mellitus: an exploratory study from India. Int J Diabetes Dev Ctries. 2015. 13. Andrade C. A critical examination of studies on curcumin for depression. J Clin Psychiatry. 2014; 75(10): e1110–2. 3. Achalia RM, Chaturvedi SK, Desai G, Rao GN, Prakash O. Prevalence and risk factors associated with tardive dyskinesia 14. Andrade C. Fruit juice, organic anion transporting polypeptides, among Indian patients with schizophrenia. Asian J Psychiatr. and drug interactions in psychiatry. J Clin Psychiatry. 2014; 2014; 9: 31–5. 75(11): e1323–5. 4. Achalia R, Andrade C. Reversible abnormality of the splenium 15. Andrade C. Cost of treatment as a placebo effect in in a bipolar patient with neuroleptic malignant syndrome. psychopharmacology: importance in the context of generic Bipolar Disord. 2014; 16(7): 773–5. drugs. J Clin Psychiatry. 2015; 76(4): e534–6. 5. Agarwal RK, Dhanya R, Parmar LG, Vaish A, Sedai A, 16. Andrade C. Cause versus association in observational studies in Periyavan S. A study of the noncompliance of blood banks psychopharmacology. J Clin Psychiatry. 2014; 75(8): e781–4. on safety and quality parameters in blood donation camps in Bengaluru. Asian J Transfus Sci. 2015; 9(1): 23–8. 17. Andrade C. A primer on confidence intervals in psychopharmacology. J Clin Psychiatry 2015; 76(2): e228–31. 6. Ahmed M, Sriganesh K, Vinay B, Umamaheswara Rao GS. Acute kidney injury in survivors of surgery for severe traumatic 18. Andrade C. Nonsteroidal anti-inflammatory drugs and 5-HT brain injury: Incidence, risk factors, and outcome from a serotonin receptor antagonists as innovative antipsychotic tertiary neuroscience center in India. Br J Neurosurg. 2015; 1–5. augmentation treatments for schizophrenia. J Clin Psychiatry. 2014; 75(7): e707–9. 7. Amar BR, Yadav R, Janardhan Reddy YC, Pal PK. A clinical profile of patients with Parkinson’s disease and psychosis. Ann 19. Andrade C. Potentially significant versus clinically significant Indian Acad Neurol. 2014; 17(2): 187–92. drug interactions: pomegranate juice as a case in point. J Clin Psychiatry. 2014; 75(4): e292–3. 8. Amaresha AC, Danivas V, Shivakumar V, Agarwal SM, Kalmady S V, Narayanaswamy JC, et al. Clinical correlates 20. Andrade C. The numbers needed to treat and harm (NNT, of parametric digit-symbol substitution test in schizophrenia. NNH) statistics: what they tell us and what they do not. J Clin Asian J Psychiatr. 2014; 10: : 45–50. Psychiatry. 2015; 76(3): e330–3. 9. Amaresha AC, Venkatasubramanian G, Muralidhar D. 21. Andrade C. A primer for the conceptualization of the Needs of siblings of persons with psychosis: a systematic mechanism of action of electroconvulsive therapy, 2: organizing descriptive review. Clin Psychopharmacol Neurosci. 2014; the information. J Clin Psychiatry. 2014; 75(6): e548–51. 12(2): 111–23.
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22. Andrade C. Selective serotonin reuptake inhibitor drug 34. Arthur JAJ, Dhanasekara R. Pandian. Spiritual beliefs and interactions in patients receiving statins. J Clin Psychiatry. quality of life among persons with alcohol dependence 2014; 75(2): e95–9. syndrome. Intl J Indian Psychol. 2015; 2: 64–74.
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28. Chandra SR, Issac TG, Abbas MM. Apraxias in neurodegenerative 40. Dheeraj Adiga, Anupam Gupta, Khanna Meeka, Taly Arun B, dementias. Indian J Psychol Med. 2015; 37(1): 42–7. Thennarasu Kandavel. Sleep disorders in children with cerebral palsy and its correlation with sleep disturbance in primary 29. Chandra SR, Seshadri R, Chikabasaviah Y, Issac TG. caregivers and other associated factors. Ann Indian Acad Progressive limbic encephalopathy: Problems and prospects. Neurol. 2014; 17(4): 473–6. Ann Indian Acad Neurol. 2014; 17(2): 166–70. 41. Dhritiman C, Vinay B. Extreme hemodynamic fluctuations: 30. Chandran D, Roopesh BN, Raj A, Channaveerachari N, Joshi Importance of understanding the principles of syringe pump S, Paramita P, Somanathan R, Kasi S BS. Psychosocial impact function. Indian J Crit Care Med. 2015; 19(4): 244–5. of the Uttarakhand flood disaster on elderly survivors. Indian J Gerontol. 2015; 29: 62–76. 42. Gandhi S, Pavalur R, Thanapal S, Parathasarathy NB, Desai G, Bhola P, et al. Medication adherence, work performance and 31. Channaveerachari NK, Raj A, Joshi S, Paramita P, Somanathan R, self-esteem among psychiatric patients attending psychosocial Chandran D, et al. Psychiatric and medical disorders in the after rehabilitation services at Bangalore, India. Indian J Psychol math of the uttarakhand disaster: assessment, approach, and future Med. 2014; 36(4): 392–6. challenges. Indian J Psychol Med. 2015; 37(2): 138–43. 43. Gangadharan J, Mahadevan A, Ramalingaiah A, Ramesh 32. Chaturvedi SK, Hamza A, Sharma MP. Changes in distressing A, Devi B. Clinical, radiological, surgical, and pathological behavior perceived by family of persons with Schizophrenia at determinants of olfactory groove schwannoma. Indian J home-25 years later. Indian J Psychol Med. 2014; 36(3): 282–7. Neurosurg. 2014; 3(2): 86.
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73. Maiti TK, Nagarjun MN, Arimappamagan A, Mahadevan A, 84. Menon N, Gupta A, Taly AB, Khanna M, Kumar SN. Pandey P. Hemangiopericytoma of pineal region: case report Neurogenic bladder following myelopathies: Has it any and review. Neurol India. 2014; 62(4): 460–2. correlation with neurological and functional recovery? J Neurosci Rural Pract. 2014; 5(Suppl 1): S13–6. 74. Maiti T, Somanna S, Devi BI, Unchagi A, Shukla D. Malignant nodular hidradenoma of scalp. J Neurosci Rural Pract. 2014; 85. Menon R, Lekha V, Justus S, Sarma PS, Mathuranath P. A 5(4): 423–5. pilot study on utility of malayalam version of addenbrooke’s cognitive examination in detection of amnestic mild cognitive 75. Manjula M, Raguram A. Experiences of stigma and impairment: A critical insight into utility of learning and recall psychological well being among adult children of parents with measures. Ann Indian Acad Neurol. 2014; 17(4): 420–5. schizophrenia. Andhra Pradesh J Psychol Med. 2014; 15: 43–9. 86. Michael RJ, Mehrotra S. How engaged are Indian youth? 76. Manjula M, Chandrashekar CR. Filicide as a part of extended Exploring behavioural indicators of youth engagement. 2015; suicide: An experience of psychotherapy with the survivor. 41(1): 127–35. Indian J Psychiatry. 2014; 56(2): 194–6. 87. Michael RJ, Sharma MK, Mehrotra S, Banu H, Kumar R, 77. Manjunath M, Kiran P, Preethish-Kumar V, Nalini A, Singh RJ, Sudhir PM, et al. Inclination to speeding and its correlates Gayathri N. A comparative study of mPCR, MLPA, and muscle among two-wheeler riding Indian youth. Ind Psychiatry J. biopsy results in a cohort of children with Duchenne muscular 2014; 23(2): 105–10. dystrophy: a first study. Neurol India. 2015; 63(1): 58–62. 88. Mohandas AN, Bharath RD, Prathyusha PV, Gupta AK. 78. Manoj N, Arivazhagan A, Bhat DI, Arvinda HR, Mahadevan Hippocampal volumetry: Normative data in the Indian A, Santosh V, et al. Stereotactic biopsy of brainstem lesions: population. Ann Indian Acad Neurol. 2014; 17(3): 267–71. Techniques, efficacy, safety, and disease variation between adults and children: A single institutional series and review. J 89. Munivenkatappa A. Does India need dual degree to improve its Neurosci Rural Pract. 2014; 5(1): 32–9. academic progress? J Res Educ Indian Med. 2015;
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144. Sailaxmi Gandhi, Mythili DT. Comparison of traditional Vs spectrometry. Indian J Med Res. 2015; 141(1): 75–80. Modern teaching strategies on learning outcome of nursing students. JKIMSU. 2015; 4: 123–9. 157. Sharma P, Murthy P, Shivhare P. Validated high-performance thin layer chromatographic method for caffeine quantification 145. Sailaxmi Gandhi, Mythili D, Thirumoorthy A. A Descriptive in beverages and edibles. 2014; 2(2): 31–6. survey to assess the teaching strategies adopted at colleges of nursing in India. RGUHS J Heal Sci. 2014; 4: 17–9. 158. Shastry A, Thota B, Durgad S, Thennarasu K, Arivazhagan A, Somanna S, et al. The influence of p53 expression status 146. Santhosh NS, Sinha S, Satishchandra P. Epilepsy: Indian on the association of STAT1 and MMP-9 with survival in perspective. Ann Indian Acad Neurol. 2014; 17(Suppl 1): S3– glioblastoma: from molecular biology towards personalized 11. medicine. Brain Pathol. 2014.
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168. Sukumar GM, Kupatira K, Gururaj G. Feasibility of integrating 182. Vandana VP, Manjula R. Perceptual speech characteristics mental health and noncommunicable disease risk factor of cerebellar dysarthria associated with lesions in different screening in periodical medical examination of employees in cerebellar loci. Lang India. 2014; 14: 357–64. industries: An exploratory initiative. Indian J Occup Environ Med. 2015; 19(1): 19–24. 183. Vandana VP. Articulatory patterns in dementia–Sequential speech motion rate measures. Research Thoughts: Multidiscip 169. Suman LN, Nagalakshmi RM, Thennarasu K. Reasons for Res J. 2014; 3: 1–5. smoking among college students. Indian J Clin Psychol,. 2014; 2: 140–5. 184. Vandana VP. Perspectives on stuttering and social anxiety. Lang India. 2014; 10: 357–64. 170. Sunitha S, Gururaj G. Health behaviours & problems among young people in India: cause for concern & call for action. 185. Velmurugan J, Sinha S, Satishchandra P. Indian J Med Res. 2014; 140(2): 185–208. Magnetoencephalography recording and analysis. Ann Indian Acad Neurol. 2014;17(Suppl 1): S113–9. 171. Thangavelu K, Moorthy AS. Effect of craniocervical flexor training and cervical flexor training on sitting neck posture in 186. Vidhya Annapoorni CS, Mongol RN, Samir Behera patients with chronic neck pain; comparative Study. Indian J CS. Pharyngeocutaneous fistula: A rare manifestation of Physical Ther. 2014. Tuberculosis. TAPIJ. 2014; 6: 10–2.
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41. Titus DJ, Shankaranarayana Rao BS, Srikumar BN. Evaluation 8. Gururaj G, Pradeep BS, Gopal Beri, Anjali Chauhan, Zoya of learning and memory in rodents. In: Jibu Thomas Rizvi. Report of the youth health survey–Himachal Pradesh. RT, Narendhirakannan, Muthukumar Nadar MSA (eds) Centre for Public Health, National Institute of Mental Health Experimental animals ethical guidelines and bioefficacy studies and Neuro Sciences, Bangalore. for biotechnological applications. Iris Publishers, Coimbatore, India. 2014. p72-90. 9. Gururaj G, Ramasubramanyam CS, Girish N, Mathew V, Sunitha S. Tamil Nadu Mental health care assessment: Review 42. Valliammal S, Ramachandra. Attitudes of Indian mothers of mental health district mental health programme, Publication regarding child rights. Proceedings of 1st Mediterranean No. 106, ISBN 81-86454-00-X, National Institute of Mental Interdisciplinary Forum on Social Sciences and Humanities, Health and Neuro Sciences, Bangalore, 2014. Beirut, Lebanon. 2014: 299 -302. 10. Hamza A, Parthasarathy R, Janardhana N, Reddy D, Mishra S. 43. Vijaysagar KJ. Pharmacotherapy of disruptive behavioral Training Manual on Adolescent sexuality reproductive health disorders. In: Sailaxmi G, Lalitha K, Ramachandra, Prasanthi and gender equality to capacitate social work trainees in India. N, Radhakrishnan, Achla DG (eds), Childhood behavioral NIMHANS Publication, Bangalore, 2014.
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11. Jangam KV,Reshma BK. Manual for Sensitization for teachers 20. Pruthvish S, Gururaj G, Srinivas R, et al. Training guide for on child abuse and neglect. Funded by RMNF, NIMHANS, identification and reporting of persons with stroke for[health 2014. workers, ASHA workers, Anganwadi workers and school teachers. MS Ramaiah Institute of Medical Sciences, 12. Manjula M, Herbert HS, Singhal M, Sharma M. Stress Bangalore, June 2014. management manual for college students and parents. NIMHANS Publication, Bangalore, 2014. 21. Ramachandra, Lalitha K, Sailaxmi Gandhi, Prasanthi N, Radhakrishnan. Evidence based practice in nursing. 13. Mehrotra S, Elias J, Chowdhury D. Trainer’s Manual on Department of Nursing, NIMHANS, January 2015. Feeling good and doing well-A mental health promotion program for youth. Bangalore: NIMHANS publication, 2014. 22. Ramachandra, Lalitha K, Sailaxmi Gandhi, Prasanthi Nattala. Handbook on Successful Mentoring in Nursing, Department 14. Murthy P, Chandra PS, Benegal V, Chand PK, Pandian D, of Nursing, NIMHANS, July 2014. Thennarasu K. Development of a partner focused intervention for alcohol dependence and assessment of impact on couple’s 23. Ravikumar R, Ramesh VJ, Arivazhagan, Girish Kulkarni. outcome. A Pilot Study. Project supported by the Indian Antibiotic Sub-committee Report prepared for NIMHANS, Council for Medical Research, 2014. Bangalore. February 2015.
15. Pradeep BS, Gururaj G, Lavanya G, Humera B. Report of the 24. Sailaxmi Gandhi, Lalitha K, Ramachandra, Mythili D. Symposium on Youth Mental Health in India: A Public Health Innovative teaching techniques in psychiatric nursing, Perspective. Centre for Public Health, National Institute of Department of Nursing, NIMHANS, November 2014. Mental Health and Neuro Sciences, Bangalore, 2014. 25. Sailaxmi Gandhi, Lalitha K, Ramachandra, Prasanthi N, 16. Pradeep BS, Gururaj G, Seema M, Lavanya G, Humera B. Radhakrishnan, Achla Dagdu Gaikwad. Childhood behavioral Annual Report of Project Yuva Spandana- Developing and disorders & its management: a multi-disciplinary approach. implementing an integrated mental health promotion services Department of Nursing, NIMHANS, January 2015. for youth through a district empowerment model in Karnataka- Youth policy 2012 initiative. Centre for Public Health, National 26. Shankar SK, Mahadevan A, Parmar SK. Histological atlas of Institute of Mental Health and Neuro Sciences, Bangalore, common infections of the nervous system with teaching slides. 2014. Released by DGICMR, Dr.V.M.Katoch, NIMHANS, 28 March 2014. 17. Pradeep BS, Gururaj G (Eds). A set 10 different modules for Yuva Parivarthakas under the Project Yuva Spandana. Yuva 27. Sriganesh K. Designed the consent form for anaesthesia/ Spandana–the project; Youth, health and lifestyle; Youth sedation for MRI study. Department of Neuroanaesthesia, and Safety; Self development and emotional regulation; NIMHANS, Bangalore 2014. Management; Supervision and training; Gender, Sex and Sexuality; Education and academic issues; Relationship issues 28. Sumathi R, Ramachandra, Parthasarathy R, Lalitha K. and intergenerational connect; and supporting skills. Manual for enrichment of life skills adjustment and quality of life of rural secondary school adolescent children. 18. Pradeep BS, Gururaj G, Seema M, Lavanya G, Humera B. Report of the Experts Workshop- Developing and 29. Sundar Periyavan. NACO Training Module for Blood Bank implementing an integrated mental health promotion services Medical Officers and Lab Technicians 2015(ii) NACO for youth through a district empowerment model in Karnataka- Training Module for Blood Bank Nurses 2015. Youth policy 2012 initiative. Centre for Public Health, National Institute of Mental Health and Neuro Sciences, Bangalore, 30. Thennarasu K, ISBN: 81-86443-00-X, Edited by: Tresa Mary 2014. MJ, Nethravathi R, George Chacko, Gnaneshwari CD, Pratima Murthy. H2H (Help to Help…) Women partner of men with 19. Pruthvish S, Gururaj G, Srinivas R, et al, Training guide for alcohol dependence: A Counselling Manual, Developed as identification and reporting of persons with stroke for medical part of an ICMR Study: Development of a partner focused officers. MS Ramaiah Institute of Medical Sciences, Bangalore, intervention for alcohol dependence and assessment of impact June 2014. on couples’ outcome: A pilot study.
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News Letters /Souvenirs Articles For General Public/ Iec Materials 1. Bindu PS. Clinical clues to the diagnosis of leukodystrophies and neurometabolic disorders. Sovenir, ISNR-2013, 16th CHILD & ADOLESCENT PSYCHIATRY Annual Conference of Indian Society of Neuroradiology Bangalore, 27 September 2013. Vijaysagar KJ (i) Understanding schizophrenia. The Week, July 2014 (ii) How safe are schools for our children?? Brainfeed Magazine, 2. Chaitanya G, Arivazhagan A, Sinha S, Madhusudan Reddy August 2014 (iii) Cyberbullying: The dark side of the internet. The KR, Thennarasu K, Bharath RD, Rao MB, Chandramouli BA, Alternative online Magazine, July 2014 (iv) Is your child safe online? Satishchandra P. Hemodynamic effects of dexmedetomidine Parent Edge Magazine, October 2014 (v) Voices from inside. The during intra-operative electrocorticography for epilepsy surgery. Week, February 2015. J Neurosci Rural Pract 2014; 5: 17-21.
CLINICAL PSYCHOLOGY 3. Lalitha Krishnasamy. Independent nurse practitioner. JSS College of Nursing, Mysore, National Conference. Empower Raguram A. How does watching too many TV serials and family Nursing: Reflecting on Challenges and Changes, 29-30 sagas affect our own relationships? The Loudspeaker, NIMHANS September 2014: 27-31. Centre for Well Being, Bangalore, 2014.
4. Nirmala BP. Expressed emotions, Work behavior and self esteem Suman LN, Jangam K, Veena AS. An educational pamphlet- NURSE: in patients with severe mental illness attending psychiatric Nurses Recovery from Stress and Exhaustion, as an initiative of the rehabilitation facility. Bharthiar University Coimbatore, Tamil Trauma Recovery Clinic. The pamphlet provides information on Nadu, 28-30 January 2015. Burnout, Secondary Trauma and Self-Care practices for recovery. NIMHANS Centre for Well-Being, Bangalore. 5. Pradnya Dhargave, Nalini A, Raju TR, Nagarathna R, Thennarasu K, Sathyaprabha TN. Souvenir released at 4th Manjula M. (i) Janaru athmahathyege eke sharanaguttare?, Prajavani, 31 BPN Conference-Correlation of age with functional abilities August, 2014 (ii) Exam stress: How can parents deal with it. Website: and muscle strength in children with duchenne muscular White Swan Foundation, March 2015. dystrophy.
Manoj K Sharma (i) NIMHANS poll find teens laid low by digital 6. Sharma MK. India opens clinic to help people “Addicted” to excess, Bangalore Mirror, 22 April 2014 (ii) Pain in tech city: mobile phones and video games. BMJ 2014; 349: g4439. Absenteeism up, productivity down, Bangalore Mirror, 8 May 2014 (iii) First tech de-addiction clinic opens; experts see ‘tip of iceberg’. 7. Sivakumar T. Psychiatric rehabilitation: A new dimension in Indian Express, 1 June 2014 (iv) Technology addiction, General holistic care. MINDS newsletter. February 2015. Public, Mint Newspaper, 4 June 2014
8. Sunder Periyavan. Donor screening. Souvenir released by Mehrotra S, Devdutt J. An Information Handout on Youth Mental the Conference Organizing Committee. 39th National Health, Bangalore. Conference of ISBTI, Patiala, Punjab.
Mehrotra S, Michael RJ. Two-wheeler rider safety, Bangalore. 9. Uma Hirisave, Bhattacharyya Snigdhasree. Seven paths to good parenting. The Loudspeaker, Autumn 2014. Mehrotra S. Two information handouts on Youth Mental Health Promotion. 10. Vijaysagar KJ, Girimaji SC. Adverse effects of psychotropic medication use in persons with Intellectual Disability– Sudhir PM , Systla R. Talking Cures for Depression, The Loudspeaker, KPAMRC Newsletter. NIMHANS Centre for Well Being, Bangalore.
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Sivakumar T, Thirthalli J, Chethan B, Pathak A, James JW, NEUROLOGICAL REHABILITATION Ahammed A, Kumar CN, Gandhi S, Kumar D, Desai G, Bhola P, Nirmala BP, Chaturvedi SK. What after me? Information material Urodynamic Study Lab: (i) Education material for patients: for family caregivers of persons with severe mental illness. Psychiatric (a) Information about Urodynamic studies Brochure (b) Clean Rehabilitation Services, Department of Psychiatry, NIMHANS, intermittent catheterization brochure for Male (c) Clean Intermittent Bengaluru. Catheterization brochure for Female (ii) Posters: (a) Information about urodynamic studies (b) CIC for Male (c) CIC for Female (d) Sivakumar T, Chethan B, Hamsa J, Murthy P, Thirthalli J, Murthy Comprehensive Neurological Rehabilitation Services. P, Math SB, Pathak A, James JW, Ahammed A, Kumar CN, Gandhi S, Kumar D, Desai G, Bhola P, Nirmala BP, Chaturvedi SK. Occupational Therapy Section: (i) Posters: (a) Hand robotics Making a will & forming a trust. Psychiatric Rehabilitation services, in occupational therapy (b) Occupational therapy for stroke (c) Department of Psychiatry and Legal Aid Clinic, NIMHANS, Multisensory integration in occupational therapy (d) Natural laws Bengaluru. of work – Ergonomics (e) One handed techniques for hemiplegic patients (f ) Occupational therapy in geriatric patients with physical Roopesh BN, Vigranth B, Kryces CT, Karni P.(i) An information deficit (g) Group interactive occupational therapy program–collage leaflet for Parents of Children with ADHD (ii) An information leaflet (ii) Brochures: (a) Occupational therapy services at NIMHANS (b) for children with ADHD (iii) An information leaflet for Teachers Occupational therapy for stroke. of Children with ADHD, NIMHANS Centre for Well Being, Bangalore. Physiotherapy Section: (i) Posters: (a) PNF techniques (b) Traumatic brain injury management– Physiotherapist perspective (c) Stroke EPIDEMIOLOGY management by physiotherapist (ii) Brochures: (a) Spinal cord injury– positioning methods (b) Prevention of subluxation in acute stage of Pradeep BS (i)Yuva Spandana, Press meet-How to Face SSLC Results, stroke by positioning and handling techniques (c) Home program for Vijayavani, 14 May 2014 (ii) Yuva Spandana, Youngsters to be Trained cerebral palsy – Physiotherapist perspective (iii) Others: (a) Collage in Counseling Distress People, Deccan Herald, 09 July 2014. on RTA rates in India (b) Outcome measures in Physiotherapy & Rehabilitation booklet (scales reliability and validity) (c)VCD on Gururaj. (i) Suicide Prevention, Article on Suicide Prevention, Neural mobilization Technique. Prajavani Bhoomika, 16 August 2014 (ii) Suicide prevention, Article Regarding Suicide on World Suicide Prevention Day, The NEUROLOGY Hindu, 10 September 2014 (iii) Road Safety, Article on use of mobiles while driving, The New Indian Express, 17 November Chandra SR (i)Public education leaflets distributed at Free medical 2014 (iv) Suicide Prevention, Article on Making Suicide Attempt camp, Mannanchery Aleppey, 25 January 2015 (ii) Free medical not a Crime, Bangalore Mirror/ Kannada Prabha, 12 November checkup for mentally disabled children, Vatsalyam, Neyyoor, 2014 (v) Road Safety, Helmet Rule, The New Indian Express, 24 Kanyakumari district, 2 May 2014. November 2014. NEUROPHYSIOLOGY Senthil. World Epilepsy Day, Awareness Regarding Epilepsy to School Children, Prajavani , 26-29 November 2014 Shankaranarayana Rao BSS. Mid brain centers leave city divided, Bangalore Mirror, 2 January 2015 (ii) Depressed? Only pills not the Girish, Mental Health, National Mental Health Survey, Udayavani. answer. Bangalore Mirror, 24 January 2015.
Gururaj, Pradeep. Yuva Spandana, Article Regarding Sports NURSING Psychology, Prajavani. NIMHANS CENTRE FOR WELL BEING IEC: The centre Gautham. Road Safety, Road Safety Awareness Week, Vijayakarnataka, in coordination with the consultants who visit the centre developed 29 January 2015. Information Education Communication leaflets in English on: (a) Trauma recovery clinic (b) Awake clinic (Intimate partner violence) Pradeep BS. Sensitizing Youth about Various Youth Related Issues, (c) SHUT Clinic (Service for healthy use of technology) (d) First Vijayakarnataka,05 March 2015. hand information for intimate partner violence (e) Nurse: Nurses
260 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 recovery from stress and exhaustion - an educational pamphlet on among adolescents. White Swan Foundation for Mental Health and burnout, Secondary Trauma and Self-Care. NIMHANS.
The centre in coordination with the consultants of Awake Clinic Kavita VJ. Protecting children from sexual abuse: strategies for developed two posters on: (a) Take the first step. Stop the violence! parents. NIMHANS Centre for Well Being, Bangalore. (b)Protecting women from intimate partner violence. Speech Pathology and Audiology department Developed IEC Padmavathy D. Information Education Communication booklet in materials for Yogakshema- Health fair for senior citizens organized Kannada on-If only we know how to listen (Namage keelisikolluva by Rotary Clubs of Cantonment and Bangalore West at Rotary reethi gotthidhare maathra!!) Bangalore West.
Lalitha K. Twin-Win – fhi360- Strengthening Nursing Education Pradeep Y, Aravind Kumar R. Know about hearing loss. using Dual Role – A film by Director of Medical Education, Govt. of Andhra Pradesh, 2015. Yamini BK, Aravind Kumar R, Shivashankar N. Care for the elderly.
Sailaxmi Gandhi, Lalitha K. Management of specific psychiatric Meera SS, Yamini BK. Mild cognitive impairment in English and emergencies, 2014 (English) Kannada Languages.
Sailaxmi Gandhi, Lalitha K, Sumathi R. Medication compliance, PSYCHIATRY 2014 (Kannada) Prabha S Chandra. (i) Editor, Loudspeaker–A magazine for Mental Sailaxmi Gandhi, Lalitha K,Kochuthresia PK. Maternal mental Health, published by NIMHANS Centre for Well Being (ii) Articles health with focus on mother-baby bonding, 2014 (Kannada) on women’s mental health in Head Coach. Monthly Column in the Prevention Magazine. Lalitha K, Ramachandra, Sailaxmi Gandhi,Rajeswari C,Kanitha D. (a) IEC Materials-breast feeding practices and harmful effect of Sivakumar T, Lath W, Chethan B. NIMHANS calendar 2015 with formula/cow/mixed feeding (b) Hygienic tips for postnatal mother (c) patient’s artwork. Psychiatric Rehabilitation Services, Department of Breast care for postnatal mothers (d) Expression and storage of breast Psychiatry, NIMHANS, Bengaluru. feeding (e) Positions during breast feeding (f ) Adequacy of breast feeding (g) Breast enlargement and its management (h) Advantages of breast feeding (i) World Breast Feeding Week Celebrations, Postnatal Books Published Mothers and their relatives, Printed Media (Handouts),1-7 August 2014. 1. Mehrotra S, Devdutt J. Voices of Hope. NIMHANS Publication, Bangalore, 2014. Lalitha K, Ramachandra, Sailaxmi Gandhi, Valliammal S (a) Newborn care (b) Sensory stimulation of baby (c) Developmental milestones of 2. Chandra SR. Section Editor (Neurology), Textbook of baby (d) Common concerns of the first time mother. Medicine (6th Edition) by Professor K.V.Krishnadas.
PSYCHIATRIC SOCIAL WORK 3. Prabha S. Chandra. The Loudspeaker–Amplifying the Voice of Mental Health. NIMHANS Centre for Well Being, Bengaluru, Vranda MN. An information leaflet on Stop violence and seek 2014. help (ii) Information about Intimate partner Violence (iii) First- hand information leaflet on safety measure for women to prevent 4. Vranda MN. Promotion of mental health and psychological intimate partner violence (iv) Web articles on (a) Promotion of well-being of adolescents in schools. NIMHANS Publication, Mental Health and Wellbeing of Adolescents in schools (b) Suicide NIMHANS, Bangalore, 2014.
National Institute of Mental Health and Neuro Sciences 261| Annual Report 2014-15 Contributions to Scientific Deliberations
International its applications in psychiatry Preconference workshop (b) Practical psychopharmacology: psychotropic drug interactions in patients with ischemic heart disease (c) Practical 1. Abhishek Lenka, Ketaki Swapnil Bhalsing, Ketan Ramakant psychopharmacology: Psychotropic drug interactions in Jhunjhunwala, Vijay Chandran, Pramod Kumar Pal. A profile patients with schizophrenia. 18th Malaysian Conference on of 191 patients with essential tremor: comparison of those Psychological Medicine and the First Asian Federation of with and without head tremor. 18th International Congress Psychiatric Association Regional Meeting, Kuala Lumpur, of Parkinson’s disease and Movement Disorders, Stockholm, Malaysia, 22-24 May 2014 (ii) (a) Theoretical framework for Sweden, June 2014. the mechanism of action of ECT. Part 1: General issues. (b) Part 2: Amygdala and Hippocampus. 1st Global Conference 2. Achla Dagdu Gaikwad. Effectiveness of play therapy on family of Biological Psychiatry, New Delhi, 25-28 September 2014 stress, coping and selected variables of children with disruptive (iii) SSRIs in ischemic heart disease: mechanisms of benefit behavior disorders: a pilot study. International Symposium on harm and drug interactions. 1st Global Conference of Global Mental Health. Rajagiri College of Social Sciences, Biological Psychiatry, New Delhi, 25-28 September 2014 (iv) Kalamassery, Kerala, 7-9 January, 2015. Treatment of painful symptoms in depression. Mental Health Society, Myanmar Medical Association, Yangon, Myanmar, 3. Ahammed A, Pathak A, Chethan B, Sujai R, James JW, Reddy 26 October 2014, RP, Vijayan TV, Sivakumar T, Kumar CN, Gandhi S, Nirmala BP, Bhola P, Kumar D, Desai G, Thirthalli J, Chaturvedi 8. Aravind Raj E, Sekar K, Soyuz John. Impact of assisted SK. Rehabilitation in a person with borderline intellectual employment programme on patients admitted in residential function: a case report. 5th Asia Pacific Regional Conference care services of Sakalawara community mental health center- on Psychosocial Rehabilitation, Bengaluru, 6-8 February 2015. an assessment using ICF coding. 5th Asia Pacific Regional (Best Poster Award) Conference on Psychosocial Rehabilitation, M.S. Ramaiah Medical College, Bengaluru, 6-8 February 2015. 4. Ahluwalia H, Mohide A, Kedia S, Basu A, Rawat VS, Chand PK, Murthy P, Suman LN. Cognitive behavioral intervention 9. Arivazhagan A. (i) Expression of tumor associated macrophage in a case of compulsive shopping. International Conference on markers in pediatric glioblastoma (ii) Surgery for drug resistant Cognitive-Behavioral Interventions, New Delhi, 2-3 March epilepsy in children - clinical spectrum, surgical techniques and 2015. outcome (iii) Paediatric spine injuries– a retrospective analysis of peculiarities and patterns over a decade. 24th Congress 5. Alok Sarin, Sanjeev Jain, Sudipto Chatterji P Radhika. of European Society for Pediatric Neurosurgery, Angelicum Work and the madhouse: a historical appraisal. 5th Asia Congress Center, Rome, Italy, 4-7 May 2014. Pacific Regional Conference on Psychosocial Rehabilitation, Bangalore, 6-8 February 2015. 10. Arthur JAJ, Dhanasekarapandian R. (i) Intensive case management for alcohol dependence syndrome-a case 6. Amudhan S, Girish N, Gururaj G. Health management study. International Symposium on Evidences in Global information system for strengthening services of mental, Mental Health, DYUTI-Rajagiri College of Social Sciences, neurological & substance use disorders in a district. 14th World Kalamacherry, 7-9 January 2015 (ii) Assertive community Congress on Public Health 2013, Kolkata, 12 February 2014 treatment for alcohol dependence syndrome: a case study, (ii) Developing a roadmap for integrated child health services 5th Asia Pacific Regional Conference on Psycho-social - situational analysis of child mental health in Kolar District, Rehabilitation, Bangalore, 6-8 February 2015. Karnataka, India. 14th World Congress on Public Health 2013, Kolkata, 12 February 2014. 11. Ashwin YB, Sampada Sudarshan, Reeta Mani, Madhusudana SN. Evaluation of herbal extract for its anti-viral activity against 7. Andrade C. (i) (a)Transcranial direct current stimulation and
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rabies virus. 25th Rabies in the Americas Conference, Cancun, 20. Bhola P. Best practices and potential problems implementing Mexico, 26-30 October 2014. a longitudinal study of trainee development. Society for Psychotherapy Research. 45th International Annual 12. Balachandar R, Bharath S, John JP, Saini J. Resting state Meeting. Copenhagen, Denmark, 25-28 June 2014 (ii) Social functional connectivity of executive network predicts the skills assessment and training. Psychiatric Rehabilitation, performance of cognitive function; Alzheimer’s Association International Conference on Schizophrenia. Chennai, International Conference 2014 (AAIC) Copenhagen July 21-23 August 2014 (iii) Ethical issues in counselling and 2014. psychotherapy. International Conference on Emerging Role of Guidance and Counseling in Health and Wellbeing. Udaipur, 13. Balachandar R, Bharath S, John JP, Kumar K, Joshi H et 18-19 November 2014. al. Resting State functional connectivity changes associated with visuo-spatial cognitive deficits in patients with mild Alzheimer’s 21. Bhola P. Recovery oriented services: assessment and disease, 12th International Conference on Alzheimer’s disease documentation. Sensitization Programme on Psychiatric and Parkinson’s disease 2015 (ADPD), Nice, March 2015. Rehabilitation. St. Annes Degree College for Women, Bangalore, 5 August 2014. 14. Batra M, Menon IS, Bhola P, Thirthalli J. Discrepancy & trust: handling rupture in therapeutic alliance in cognitive behavior 22. Bindu M Kutty. Meditation, brain plasticity and sleep therapy. International Conference on Cognitive Behavioral organization. 8th Asian Sleep Research Society, Kovalam, Interventions. 28 February-4 March 2015. (Best Paper Award). Thiruvananthapuram, 22-24 September 2014 (ii) Meditation, brain plasticity and cognitive functions, DST- Royal Society 15. Bhagyalakshmi Shankarappa, Shweta Byrappa, Rashmi India UK Scientific Seminar 2015, Translational Neuroscience Chandra, Sandeep Kandregalu, Meera Purushottam, Biju in Altered States of Consciousness Linking Neuroimaging of Viswanath, Sanjeev Jain, Pratima Murthy. Study of mthfr Brain and Anesthesia for Improved Diagnosis and Prognosis. polymorphism c677t in alcohol dependence. 37th Annual RSA NIMHANS, 7-9 March 2015. Scientific Meeting, Bellevue, Washington, 21- 25 June 2014. 23. Chaitanya G, Sinha S, Majumdar K, Satishchandra P. Ictal 16. Bharath RD, Gohel S, Panda R, Biswal B. Transcranial and interictal high frequency oscillations (HFOs) in absence magnetic stimulation induced modulations of resting state seizures scalp EEG in patients with absence epilepsy–an ICA motor connectivity in writer’s cramp. 4th Biennial Conference based approach. 10th Asian Oceanian Epilepsy Congress, on Resting State/Brain Connectivity, Cambridge, USA, Brain Singapore 7-10 August 2014. Connectivity. 24. Chaitanya G, Sinha S, Satishchandra P. Ripples and waves in 17. Bharath RD, Sinha S, Panda R, George L, Raghavendra absence epilepsy: high frequency oscillations in scalp EEG, K, Gupta AK, Satishchandra P. Effect of seizure frequency 10th Asian and Oceanian Epilepsy Congress, Singapore, 7-10 on the properties of functional brain networks: novel August 2014. observations in patients with drug naïve hot water epilepsy. 10th Asian and Oceanian Epilepsy Congress, Singapore, 25. Chandra PS, Desai G, Srinivasan S, Satyanarayana VA, Jangam 7-10 August 2014. K, Thennarasu K, Venkatram L, Muralidhar A. Are somatic symptoms in pregnancy an idiom of psychological distress? 6th 18. Bharathi S, Aravind Raj E. Description of stress management World Congress on Women’s Mental Health, Tokyo, Japan, 22- programme for first year medical students at Melaka Manipal 25 March 2015. medical college, Manipal Campus. International Conference for Academic Disciplines, American University of Rome, 26. Chandra PS, Ganjekar S, Babu G, Harish T, Desai G. Rome, 28-31 October 2014. Depressive symptoms in women with postpartum onset bipolar disorder and their relationship to outcomes. Symposium on 19. Bhola P, Raguram R. Doing, being and becoming: perceptions Bipolar Disorders. Marce Conference on Perinatal Psychiatry, of therapeutic challenges and coping among trainee therapists September, Swansea, UK in India. The experiences of psychotherapist trainees: New Studies from the SPR collaborative research network. Society 27. Chandra PS, Gayatri S, Desai G. Detecting and managing risk for psychotherapy research. 45th International Annual Meeting. to mother and infant in a mother-baby unit in India using a tool Copenhagen, Denmark, 25-28 June 2014. - the FIRST MB (Formal Initial Risk Assessment for Mothers
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and Babies) -Symposium on Mother Baby Units. Marce 35. Chirag Solanki (i) Predictors and outcome of rebleed in Conference on Perinatal Psychiatry, September, Swansea, UK. aneurysmal subarachnoid hemorrhage before surgical or endovascular intervention. NEUROVASCON 2014 (ii) 28. Chandra PS, Shanthakumari S, Stewart D. Resilience in the Omovertebral – A rare complex bony abnormality associated face of partner violence among women in India - how can the with rare congenital shoulder and spine deformities and its findings inform better mental health interventions? 6th World clinical implications. SPINE 2014. Congress on Women’s Mental Health, Tokyo, 22-25 March 2015. 36. Desai A, Vijayalakshmi R, Shankar SK, Ravi V. Molecular mimicry between Chikungunya virus and host components: 29. Chandra PS, Veena AS. Development and feasibility of a a possible mechanism for arthritic manifestations. 4th World complex intervention for mental health among young women Congress of Virology, San Antonio, USA, 6-8 October 2014. from low income settings. 6th World Congress on Women’s Mental Health, Tokyo, 22-25 March 2015. 37. Desai G. (i) Innovations in teaching in psychosocial rehabilitation. International Conference on Schizophrenia 30. Chaturvedi SK. (i) Recovery oriented services: obstacle is SCARF, Chennai, 21-23 August 2014 (ii) How does the path. ICONS SCARF, Chennai 21-23 August 2014 (ii) postpartum psychosis impact breast feeding? – a report from Present & future of psychiatric rehabilitation. Psychiatrika a mother baby unit in India. The International Marce Society 2014, Beijing, 19- 20 June 2014 (iii) International faculty for Conference for Perinatal Mental Health, Biennial Scientific a skills training programme focused on the care of patients Conference, Swansea University, Swansea, Wales, UK, 10-12 with comorbid diabetes and depression in Dhaka, Bangladesh September 2014. from 27-29 June 2014 (iv) Interim results INTERPRET-DD Investigators’ Meeting, Munich, 1-3, December 2014. 38. Dhiman V, Sinha S, Arivazhagan A, Mahadevan A, Bharath RD, Saini J, Jamuna R, Rao MB, Shankar SK, Satishchandra 31. Chaturvedi SK, Pathak A. Evidence based practices in P. Predictors of spontaneous seizure remission in patients of psychiatric rehabilitation services: are they relevant? 5th Asia medically refractory epilepsy due to mesial temporal sclerosis. Pacific Regional Conference on Psychosocial Rehabilitation 10th Asian & Oceanian Epilepsy Congress, Singapore, 7-10 organized by World Association for Psychosocial Rehabilitation. August 2014. M.S. Ramaiah Hospital, Bengaluru, 6-8 February 2015. 39. Druva Ithal, Kannan K, Jagadeeh Thirtha Halli, Naveen Kumar 32. Cherian AV, Dhanasekarapandian R, Suresh BM, Thennarasu C, Shamsundar, Gangadhar BN. Comparison of cognitive K, Reddy YCJ. Family burden and associated factors in relatives adverse effects and efficacy of 2 pulse widths (0.5ms & 1.5ms) of people with obsessive–compulsive disorders. 16th World during brief pulse electro convulsive therapy in schizophrenia Congress of the World Psychiatric Association, Madrid, Spain, patients-a randomized single blind controlled trial. 1st Global 14-18 September 2014. Conference of Biological Psychiatry, Delhi, 25-29 September 2014. 33. Chethan B, Sivakumar T, Thirthalli J, Pathak A, Ahammed A, Sujai R, James JW, Reddy RP, Vijayan TV, Kumar CN, Gandhi 40. Dwarakanath Srinivas. Management strategies in trigeminal S, Nirmala BP, Bhola P, Kumar D, Desai G, Chaturvedi SK. schwannomas. 12th Asia-Oceanic International Skull Base Quality of life, enjoyment and satisfaction among clients meet, Mumbai, 9-11 January 2015. attending day care at psychiatric rehabilitation services, NIMHANS, Bangalore: a pilot study. 5th Asia Pacific Regional 41. Gowri Yale, Reeta Mani, Ganesan PI, Madhusudana Conference on Psychosocial Rehabilitation, Bengaluru, 6-8 SN, Shankar SK, Mahadevan A, Sanyal S, Shaheen Taj, February 2015. Vijayabharathi M. Skin-an alternate sample for rabies diagnosis in dogs. 25th International Meeting of Rabies in the 34. Chethan B, Thirthalli J, Pathak A, Ahammed A, Sujai R, James Americas, Cancun, Mexico, 26-30 October 2014 (RITA/WPA JW, Reddy RP, Vijayan TV, Sivakumar T, Kumar CN, Gandhi Asian Investigator and Travel Award) S, Nirmala BP, Bhola P, Kumar D, Desai G, Chaturvedi SK. Utility of outpatient services at psychiatric rehabilitation 42. Gurha A, Suman LN. Rehabilitation of juvenile delinquents in services, NIMHANS, Bangalore. 5th Asia Pacific Regional conflict with the law. 5th World Association for Psychosocial Conference on Psychosocial Rehabilitation, Bengaluru, 6-8 Rehabilitation Asia-Pacific Regional Conference, Bangalore, February 2015. 6-8 February 2015.
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43. Gururaj G. Building road safety information systems in low on Health Ageing and Changing World 2014, Bangalore, 17- and middle income countries: results from five years of data 19 November 2014. integration and demonstration programmes in Bangalore, India. Road Safety Symposium and Exhibition, Ankara, 49. Ithal D, Kannan K, Shyamsundar A, Kumar CN, Thirthalli J, Turkey, 21-24 May 2014 (ii) Engaging stakeholders and impact Ramesh VJ, Gangadhar BN. Comparison of cognitive adverse of partnerships in road safety legislation. International Road effects and efficacy of two pulse widths (0.5 ms and 1.5 ms) Safety Legislation Workshop, World Health Organization, during brief pulse electroconvulsive therapy in schizophrenia Geneva, 13-17 August 2014 (iii) Emergency medical systems patients: a randomized single blind controlled study. in India–an overview. International Road Safety Symposium International Brain Stimulation Conference, Singapore, March and Road Safety 10 Collaborators Meeting, Baltimore, USA, 2015. 16 -20 October 2014 (iv) Driving under the influence of drugs and road safety in India: current scenario, WHO Technical 50. Jain S. (i) Psychological symptoms in 19th Century India, Consultation Meeting On Drugs And Driving, Geneva, 17- British-Indian Psychiatry Association, Annual Conference, 20 December 2014 (v) Analysis of highway road crashes in Alfreton, Derbyshire, UK, 7-8 June 2014 (ii) Culture, psychiatric India: pattern, determinants and outcomes. Workshop on Road diagnosis and classification: historical and contemporary aspects Traffic Injuries in Low and middle Income Countries. Road from India; The Royal College of Psychiatrists. International Traffic Injury Research Network. Hanoi, Vietnam, 16-19 Congress 2014, 24-27 June 2014. March 2015. 51. Jairamprasad Jyothi, Mahadevan A, Shankar S, Raju TR, Alladi 44. Hamza A, Reddy D, Partha Sarthy R, Janardhan N, Suchismita PA. Effect of age on 2’, 3’-cyclic nucleotide phosphodiesterase M. Development of training manual on reproductive expression in the substantia nigra pars-compacta of Asian- health for post graduate social work trainees in India. Joint Indians. 4th Asian and Oceanian Parkinson’s Disease and World Conference on Social Work, Education and Social Movement Disorders Congress, Pattaya, Thailand, 28-30 Development, Melbourne, Australia, 9-12 July 2014. November 2014.
45. Harinarayan CV, Srinivasa P Munigoti, Thennarasu K, Leena 52. James JW, Nilofer B, Sivakumar T, Chethan B, Ashfaq Apicatala, Seema Ismail Inamdar. Vitamin D supplementation A, Abishek P. Road to recovery: A case report. 5th Asia therapy–efficacy of three different protocols. Abstract presented Pacific Regional Conference on Psychosocial Rehabilitation, at AACE – 2014, Las Vegas, USA. Bangalore, 6-8 February 2015.
46. Harish G, Anita M, Nupur P, Vinuth NP, Prasad TSK, Shankar 53. Janardhan Reddy YC. Neuropsychological and neuroimaging SK, Bharath MMS. Biochemical, histological and proteomic endophenotypes of OCD. The Inaugural Indo-US characterization of contusion and peri-contusion during Translational Neuroscience Symposium- Biomarker Discovery traumatic brain injury. (i) 12th Meeting of The Asian-Pacific & Validation. Johns Hopkins Medical School, Baltimore, USA, Society for Neurochemistry, Kaohsiung (Ta-Kao), Taiwan, 23- 25-26 February 2015. 26 August 2014 (APSN-ISN Travel Award and Silver Award for Best Presentation) (ii) 37th Japan society for Neuroscience, 54. Jaychandran R, Chaitanya G, Sinha S, Bharath RD, Yokohama, 11-13 September 2014. (IBRO Travel Award) Satishchandra P. Continuous SaO2, BP and HRV monitoring during periictal period during VEEG recording in patients 47. Indira Devi B. (i) Drezotomy as an alternative for management with drug resistent localization related epilepsy. 10th Asian of dysesthetic pain in brachial plexus injuries. 2nd AIIMS Oceanian Epilepsy Congress, Singapore, 7-10 August 2014. Neurotrauma Conference organized by Department of Neurosurgery, Neurosciences Center & JPN Apex Trauma 55. Jaychandran R, Satishchandra P, Chaitanya G, Bharath RD, Centre, AIIMS, New Delhi, 30 October-2 November 2014 (ii) Thennarasu K, Sinha S. Alterations in peri-ictal heart rate, Autonomic dysfunction in brain and spinal injury. Autonomic ECG, oxygen saturation and blood pressure in localization Dysfunction February 2015. related drug resistant epilepsy during video EEG recording. 10th Asian & Oceanian Epilepsy Congress, Singapore, 7-10 48. Issac TG, Soundarya S, Christopher R, Chandra SR. Vitamin August 2014. B12 deficiency: an important reversible co-morbidity in neuropsychiatric manifestations. World Congress of 56. Joshi PG. Neuron-glia signaling networks in the brain. Gerontology and Geriatrics and 3rd International Conference International Symposium on Translational Neuroscience
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and 32nd Annual Conference of the Indian Academy of Trust International Congress, Copenhagen, Denmark, 18-21 Neuroscience, NIMHANS, Bangalore, 1-3 November 2014. September 2014.
57. Karan KR, Satishchandra P, Sinha S, Anand A. Mutation in 66. Kulkarni KR, Arasappa R, Muralidharan K. Persistent SLC1A1 for hot water epilepsy. 10th Asian and Oceanian delusional disorder: a retrospective chart review. International Epilepsy Congress, Singapore, 7-10 August 2014. Congress of the Royal College of Psychiatrists, London, UK, June 2014. 58. Kavita Jangam, Sekar K, Sanjeev Jain. Challenges in rehabilitating women with chronic severe mental illness: insight 67. Kumar R, Kumar KJ, Benegal V, Roopesh BN. Remediation from the case studies. 5th Asia Pacific Regional Conference on program for enhancing executive control & self-regulation Psychosocial Rehabilitation February 2015. for alcoholism. 5th Asia Pacific Regional Conference on Psychosocial Rehabilitation. Bengaluru, 6-8 February 2015. 59. Kavita Jangam, Muralidharan K, Tansa KA. Association between childhood abuse and suicide among women diagnosed 68. Madhusudana SN, Reeta Mani, Satish Chandra P, Netravati with bipolar affective disorder and unipolar depression. M, Veeranna MG, Aaron De Souza, Vrajesh Udani, State Bipolar Disorder Society, NIMHANS, Bangalore, 14 Ashwin YB, Ashwini Shetty. Human rabies survivors: December 2014. From scientific curiosity to scientific reality. 25th Rabies in the Americas Conference held at Cancun. Mexico, 26-30th 60. Ketaki Bhalsing, Keshav J, Jitender Saini, Ravi Yadav, October 2014. Arun Gupta, Pramod Pal. Structural correlates of cognitive impairments in essential tremor. 4th Asian and Oceanian 69. Mahati K, Bhagya V, Raju TR and Shankaranarayana Rao Parkinson’s Disease and Movement Disorders Congress, BS. Novel therapeutic strategies to treat depression-induced Pattaya, Thailand, 28-30 November 2014. cognitive deficits. International Conference on Development, Degeneration and Regeneration of Neurons: Neurochemistry 61. Ketan Jhunjhunwala, Pramod Kumar Pal. Clinical profile of to Clinical Neurology. Institute of Post-Graduate Medical 125 patients with writer’s cramp from India. 18th International Education and Research and CSIR-Indian Institute of Congress of Parkinson’s Disease and Movement Disorders, Chemical Biology, Kolkata. 7-10 January 2015. Stockholm, Sweden, 8-12 June, 2014. 70. Malik K, Benegal V, Murthy P, Chand, PK, Arun K, Suman 62. Kini U, Babu MK, Mohanty S, Divya P, Das K, Nandeesh LN. Hospital audit of women substance users: findings BN, Yadav L. Role of rapid improvised acetylcholinesterase and implications. 8th International Conference of SAARC histochemistry in the diagnosis of Hirschsprung’s disease: a 14 Psychiatric Federation, Lumbini, Nepal, 27-29 November year prospective study of 1890 rectal biopsies at a referral centre 2014. in India. United States and Canadian Academy of Pathology, Boston, 21-27 March 2015. 71. Malla BR, Arivazhagan A, Sinha S, Chandramouli BA, Satishchandra P. Spectrum of paediatric epilepsy surgery at 63. Kisley Kishore, Paritosh Pandey, Tanmoy Maiti, Indira Devi B, NIMHANS, Bangalore. 10th Asian and Oceanian Epilepsy Sampath S, Vivek Gupta, Hemangiopericytoma-analysis of a Congress, Singapore, 7-10 August 2014. series of 41 patients to determine best management strategy. EASN 2014, Prague, 12-17 October 2014. 72. Manjula V, Shah A. Cognitive behavioral approaches in couple therapy. International Conference on Cognitive Behavioral 64. Kulkarni Girish Baburao, Abbas Masoom M, Veerendrakumar Interventions, New Delhi, 2015. M. Subcutaneous unfractionated heparin (SC UH) followed by oral anticoagulation in deep cerebral venous sinus thrombosis 73. Manjunath. A comparative study of mPCR, MLPA and muscle (DCVT). 9th World Stroke Congress, Istanbul Turkey, 22-25 biopsy results in a cohort of children with Duchenne muscular October 2014. dystrophy: a first study. AOCM 2015, Thailand, 1-4 March 2015. 65. Kulkarni Girish Baburao, Rao G, Gururaj G, Subbakrishna DK, Steiner T, Stovner LJ. The prevalence and burden of 74. Manjunatha MV. Incorporation of NKT cell activating migraine in India: results of a population-based study in glycolipids to improve Mycobacterium bovis BCG as a vaccine Karnataka state. 4th European Headache and Migraine delivery vector for viral antigens, Annual Scientific Meeting of
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Wellcome Trust Center for Global Health Research conducted disorder: the role of depressive episodes and mood stabilizers. at Chester, UK, 15 September 2014. 1st Global Conference of Biological Psychiatry, New Delhi, 25- 29 September 2014. 75. Maya Dattatraya Bhat, Bindu PS, Netravathi M, Nagappa M, Rita Christopher. Imaging spectrum of peroxisomal disorders- 83. Mythili D, Vijayalakshmi P. Effectiveness of concept mapping an institutional study. Indian Radiological and Imaging in improving nursing student’s knowledge and attitudes related Association, Kochi 29 January-1 February 2015. to HIV/AIDS. NIMRCPPSYCON, 7-8 of March 2014.
76. Maya Dattatraya Bhat, Chandrajit Prasad, Bindu PS. Novel 84. Nair AK, Maruthai N, Nagendra RP, Srikumar S, Sasidharan findings in two cases of biotinidase deficiency—a treatable A, Kutty BM. NREM stage 2 characteristics in mindfulness metabolic disorder. Radiological Society of North America- meditators: a whole night polysomnography study. 8th 100th Scientific Assembly and Annual Meeting, Chicago, 30 Congress of Asian Sleep Research Society, 22-24 September November-5 December 2014. 2014, Thiruvananthapuram, Kerala.
77. Medhi G, Gupta AK, Arvinda HR, Pendharkar H, Prasad C, 85. Nalini A. T2 relaxometry in prognosticating seizure outcome Saini J, Nethravathi M. Role of transverse sinus stenting in the at 6 months in patients with solitary cerebral cysticercosis. management of selected patients with idiopathic intracranial 10th Asian & Oceanian Epilepsy Congress, Singapore, August hypertension. European Congress of Radiology-2015, Vienna. 2014. (Best Platform Presentation Award) (ii) Monomelic 4-7 March 2014. amyotrophy madras motor neuron disease at the institute. (a) Department of Neurology, University of Massachusetts, Harvard 78. Mehta UM, Eack SM, Thermenos HW, Mesholam-Gateley R, Medical School, USA, 7-12 October 2014 (b) Department of Mathew IT, Keshavan MS. Morphometry of the mirror neuron Neurogenetics, NIH, Bethesda, USA, 15 October 2015 (iii) system and social cognition performance in schizophrenia. 15th A comparative analysis of findings by mPCR, MLPA and International Congress on Schizophrenia Research, Colorado muscle biopsy in a cohort of children with Duchenne muscular Springs, USA, 31 March 2015. dystrophy: a first prospective study, AOMC, Bangkok March 2015 (iv) LGMD 2I and 2K : α-dystroglycanopathies among 79. Mehta UM, Waghmare AV, Thirthalli J, Venkatasubramanian ARLGMD patients in India. AOMC, Bangkok, March G, Gangadhar BN. Enhancing mirror neuron activity in 2015 (v) (a) Titin-cap (TCAP) polymorphisms associated humans: a transcranial magnetic stimulation study. CME on with LGMD2G among Indian patients with ARLGMD (b) Cognitive Remediation in Psychiatry, Columbia University, Fatty acid oxidation disorders presenting as primary myopathy New York, USA, 6 June 2014. and identified by tandem mass spectroscopy. 14th Asian and Oceanian Congress of Neurology, Macua, China, 2-5 March 80. Mehta UM. (i) Asian Indians in the US: mental health 2014. overview. 1st Indian American Psychiatrists Association, Boston Chapter, Massachusetts Mental Health Center, Boston, 86. Nandakumar DN, Palaniswamy R. Glioblastoma cells exploit USA, 16 October 2014 (ii) Social cognition, mirror neurons glutamate mediated pathway for promotion of growth and & schizophrenia: concepts to novel treatment. Grand Rounds its protection. 12th Meeting of Asian-Pacific Society of at the Beth Israel Deaconess Medical Center, Department of Neurochemistry-2014, Kaohsiung, Taiwan, 23-26 August Psychiatry, Harvard Medical School, Boston, USA, 30 October 2014. 2014. 87. Naveen GH, Varambally S, Thirthalli J, Rao M, Christopher 81. Munlamuri RC, Sinha S, Satishchandra P, Nagappa M, Taly R, Nagarathna R, Gangadhar BN. Association between serum AB, Maheshwara Rao U, Prathyusha PV, Subbakrishna. BDNF and cortisol levels in drug-naive patients with depression Comparison of Phenytoin, Sodium Valproate and Levetiracetam treated with yoga therapy or antidepressants. 23rd European in the management of convulsive generalized convulsive status Congress of Psychiatry. Vienna, Austria, 28-31 March 2015. epilepticus: a prospective randomized controlled study. 10th Asian and Oceanian Epilepsy Congress, Singapore, 7-10 88. Nayak CS, Sinha S, Ramachandraiah CT, Nagappa M, August 2014. Thennarasu M, Satishchandra P. The effect of Valproic acid on the sleep quality of juvenile myoclonic epilepsy patients: 82. Muralidharan K, Kozicky JM, Bucker J, Silveira LE, Torres IJ, a longitudinal sleep questionnaire-based study, Sleep 2014, Yatham LN. Determinants of cognitive deficits in early bipolar Minneapolis, USA, 31 May-4 June 2014.
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89. Netravathi M. Clinical, imaging and electrophysiological Conference on Psychosocial Rehabilitation, Bengaluru, 6-8 characterization of post-trauma movement disorders. 14th February 2015 (Best Poster Award). Asian and Oceanian Congress of Neurology, Macao, China. 98. Polavarapu K, Francis J, Nalini A, Thangaraj K, Sunitha 90. Nirav P, Madhusudana SN, Deepak P et al. Phase I and Phase B, Gayathri N, Ramakrishna A, Saini J, Srinivas Bharath II clinical trials with a recombinant G protein vaccine in healthy MM, Sandhya K, Preethish-Kumar V. Mutational analysis volunteers- Safety and immunogenicity studies. 25th Rabies in of dysferlinopathy and muscle MRI characterization among the Americas Conference, Cancun. Mexico, 26-30 October Indian patients. 14th AOMC meet, Bangkok, Thailand, 1-4 2014 March 2015.
91. Nirmala BP. Recent emerging avenues challenges and holistic 99. Prabha S. Chandra. Life is to be understood backwards- the approaches towards psycho social rehabilitation practices, pregnancy outcome cohort in Bangalore and opportunities REACH Conference 2015, St. Anne’s College, Bangalore, 13 for Liverpool-NIMHANS collaboration. Liverpool Glasgow February 2015. NIMHANS Symposium, Centre for Global Health Research, Liverpool, UK, 18 September 2014 (ii) My baby doesn’t love 92. Nupur Pruthi. (i) CT based classification of axis vertebra and me- mothers with personality disorders in a perinatal psychiatry choice of screw placement. World Spine Society Meeting. service. Motherhood and Mental Health Day, Brockington Montego Bay, Jamaica, 4-6 May 2014 (ii) Clinical application of Mother Baby unit, Stafford, UK 17 September 2014. a novel CT based classification of axis vertebra. 8th Asia Pacific Cervical Spine Society Meeting, Istanbul, 13-15 November 100. Pradeep Y. (i) (a) Auditory neuropathy spectrum disorder- 2014. introduction to management (b) central auditory processing disorder- Introduction to management (c) Neuro Audiology – 93. Padmanabhan B. Structural biology of the Nrf2 negative Case studies. Voice for All Conference University of Kelaniya, regulator, Keap1. Indo-US Conference on Recent advances Srilanka, December 2014. in Structural Biology and Drug Discovery, IIT-Roorkee, 9-11 October 2014. 101. Pradnya Dhargave, Atchayaram Nalini, Raghuram Nagarathna, Trichur R. Raju, Talakad N. Sathyaprabha. Modulation of cardiac 94. Panda R, Bharath RD, Sinha S, Sahoo A, George L, autonomic functions in response to yoga and physiotherapy Raghavendra K, Biswal B, Gupta A. Complex network analysis intervention in patients with Duchenne muscular dystrophy. of hot water epilepsy in drug naïve patients. 4th Biennial 61st Annual meeting of AANEM, Savannah Georgia, USA, Conference on Resting State/Brain Connectivity, Cambridge, 29 October-1 November 2014. USA. 102. Pramod Kumar Pal. (i) Diffusion tensor imaging study in 95. Paritosh Pandey, Jagathlal G, Manish Ranjan, AANS, Seatle, patients with Parkinson’s disease: comparison between those Sanfrancisco, April 2014, USA and presented electronic posters. with and without re-emergent tremor. 18th International Congress of Parkinson’s Disease and Movement Disorders, 96. Pathak A, Ahammed A, Chethan B, Sujai R, James JW, Stockholm, Sweden, 8-12 June 2014 (ii) From ‘atherosclerotic’ Reddy RP, Vijayan TV, Sivakumar T, Kumar CN, Sailaxmi to ‘vascular’ parkinsonism: evolving concept and therapeutic Gandhi, Nirmala BP, Bhola P, Kumar D, Desai G, Thirthalli principles in the session-Movement disorders in vascular J, Chaturvedi SK. Socio-demographic profile, psychosocial diseases and hydrocephalus. 4th Asian and Oceanian correlates of inpatient referrals to psychiatric rehabilitation Parkinson’s Disease and Movement Disorders Congress, services and service utilization at a tertiary Neuro psychiatric Pattaya, Thailand, 28-30 November 2014 (iii) Uses of institute in India. 5th Asia Pacific Regional Conference on botulinum toxin update and conduct the Botulinum Toxin, Psychosocial Rehabilitation, Bengaluru, 6-8 February 2015. Indo-Swedish Educational Summit -2015, Kannur Medical College, Kannur, 10-11 January 2015 (iv) Parkinson’s disease 97. Pathak A, Ahammed A, Chethan B, Sujai R, James JW, with psychosis, REM sleep behavior disorder and impaired Reddy RP, Vijayan TV, Sivakumar T, Kumar CN, Sailaxmi cognition: is it a distinct phenotype?, The Inaugural Indo-US Gandhi, Nirmala BP, Bhola P, Kumar D, Desai G, Thirthalli J, Translational Neuroscience Symposium- Biomarker Discovery Chaturvedi SK. Awareness and utilization of disability benefits and Validation, Baltimore, USA, 25-26 February 2015 (v) (a) among persons attending daycare at Psychiatric Rehabilitation Review of the clinical spectrum and neuroimage in progressive Services, NIMHANS, Bengaluru. 5th Asia Pacific Regional supranuclear palsy (b) Case-based video presentation of
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psychogenic movement disorders. 2nd Taiwan International 110. Rao GN, Kulkarni G B, Gururaj G, Steiner TL, Stoner Congress of Parkinson’s Disease and Movement Disorders, LJ. Health care utilization for primary headache disorders: Howard Civil Service International House, Taipe, Taiwan 28- insight from Karnataka, India. European Conference on 29 March 2015 (vi) Advanced PD. Euro Park Summit: 2015 Head Ache Disorders. Copenhagen, 16-20 September -What is new in PD and movement disorders. New Delhi, 14- 2014. 15 March 2015 (vii) RBD, psychosis and impaired cognition in Parkinson’s disease: A distinct phenotype? NIMHANS 111. Rao G, Gururaj G, Kulkarni G, Subbukrishna DK, Steiner – Maastricht University Joint Workshop on Neurosciences, T, Stovner L. Health care utilization for primary headache NIMHANS Bangalore, 12-14 March 2015 disorders: insights from Karnataka, India. 4th European Headache and Migraine Trust International Congress, 103. Preethish-Kumar V, Nalini A, Pogoryelova O, Lochmuller H, Copenhagen, Denmark, 18-21 September 2014. Prasad C, Manjunath M, Polavarapu K. GNE c.2179G>A p. (Val 727 Met)–high prevalence among Asian Indians causing 112. Rao MB, Arivazhagan A, Sinha S, Bharath RD, Hegde S, GNE myopathy and muscle MRI correlation. 14th AOMC Mahadevan A, Satishchandra P. Spectrum of epilepsy surgery meet, Bangkok, Thailand,1-4 March 2015. in children. 10th Asian and Oceanian Epilepsy Congress, Singapore, 7-10 August 2014. 104. Prem N, Rao LT, Kutty BM. Characterization of sleep-wake behavior in a rat model of Schizophrenia. 8th Congress of 113. Ravi V, Govekar S, Anita Desai, Vijayalakshmi R, Reeta Asian Sleep Research Society, Thiruvananthapuram, Kerala. Mani, Latha Lakshman and Ravikumar BV. Development 22-24 September 2014 and validation of a novel rapid method for the simultaneous detection of viral pathogens causing acute encephalitis 105. Radhakrishnan M, Surve R, Umamaheswara Rao. Central syndrome. International Congress of Virology, International venous oxygen saturation following blood transfusion in Union of Microbiological Societies Montreal Quebec, Canada, neurointensive care unit patients. Euroanaesthesia Congress 27 July -1 August 2014. 2014, Stockholm, Sweden, 31 May-3 June 2014. 114. Ravindra CM, Sinha S, Satishchandra P, Nagappa M, 106. Radhika P. Jain S. Melancholia, vishaad (dejection) and Bindu PS, Taly AB, Pratyusha PV, Rao G Umamaheshwar, melankolia: the travelling circuits of melancholia in the Subbakrishna DK. Comparison of outcomes of Phenytoin, Indian context. Gloom goes global: towards a transcultural Sodium Valproate and Levetiracetam in the management of history of melancholy after 1850. Cluster of Excellence-Asia convulsive SE: A prospective randomized controlled study. and Europe, Heidelberg University, Heidelberg, 2-4 October 10th Asian and Oceanian Epilepsy Congress, Singapore, 7-10 2014. August 2014.
107. Raguram A. Families in transition: reconciling stability and 115. Sadana D, Rajeswaran J. Neurofeedback: Cognitive movement change. International Conference on Changing World– for physical palsy. World Asia Pacific Regional Conference on Changing Families: Diversity and Synergy. Tata Institute of Psychosocial Rehabilitation, MS Ramaiah Medical College, Social Sciences, Mumbai, 4 January 2015. Bangalore, 6-8 February 2015.
108. Rajini MN, Jhunjhunwala K, Yadav R, Saini J, Bharath RD, 116. Sailaxmi Gandhi (i) Impact of Music on Self-esteem in Christopher R, Pal PK. Gray matter volume change correlates older persons residing in an old age home in S. India. 17th with oxidative stress biomarker in Parkinson’s disease. 4th Asian Asia Pacific Regional Conference of Alzheimer’s Disease and Oceanian Parkinson’s and Movement Disorder Congress, International, New Delhi, 7-9 November 2014 (ii) Perception Pattaya, Thailand, 28-30 November 2014. of psychiatric patients, their family members and volunteers about domestic skills training, 5th Asia Pacific Regional 109. Raju TR. Amyotrophic lateral sclerosis–does the CSF hold Conference on Psychosocial Rehabilitation. World Association clues? Maastricht University, Maastricht, Netherlands, for Psychosocial Rehabilitation, MS Ramaiah Hospital, Amsterdam, 2 September 2014 (ii) Neuroinflammation and Bengaluru, 6-8 February 2015. neurodegeneration- from ALS perspective, NIMHANS– Maastricht University Joint Workshop on Neuropsychiatry, 117. Sampath S (i) Extended endoscopic endonasal transcilival NIMHANS, Bangalore, 12-14 March 2015. clipping of basilar top aneurysms (ii) Extended endoscopic
National Institute of Mental Health and Neuro Sciences 269| Annual Report 2014-15
endonasal surgery for anterior skull base meningiomas, 12th 124. Satyanarayana VA, Prabha Chandra. (i) Gender disadvantage, Asia-Oceanic International Skull Base Meet, Mumbai, January psychological distress and resilience in young Indian women 9-11, 2015 (ii) Training health workers in mental health interventions for women facing violence towards developing a National initiative 118. Sandhya M, Bharath RD, Panda R, Upadhyay N, Gupta A. in India. 6th World Congress on Women’s Mental Health, Imaging of resting state pathological networks in various Tokyo, Japan, 22-25 March 2015. neuropsychiatric disorders. 4th Biennial Conference on Resting State/Brain Connectivity, Cambridge, USA. 125. Satyanarayana VA, Suman LN, Kavita Jangam. Setting up a trauma recovery clinic: addressing a critical need in India. 6th 119. Sapna, Sripathy Bhat, Aravind Raj E. Pattern of alcohol use in World Congress on Women’s Mental Health, Tokyo, Japan, 22- persons with alcohol dependence syndrome and psychosocial 25 March 2015. correlates among their caregivers. 5th Asia Pacific Regional Conference on Psychosocial Rehabilitation. MS Ramaiah 126. Satyanarayana VA. Research update for fogarty career trac. Medical College, Bengaluru, 6-8 February 2015. Indo-US Fogarty Symposium. NIMHANS, Bangalore, 13-16 January 2015. 120. Sasidharan A, Kumar S, John JP, Kutty BM. Altered sleep stage 2 dynamics and disrupted sleep among patients with 127. Sekar K. (i) Country research proposal on ‘Youth mental health recent-onset schizophrenia: a whole night polysomnography in India’. Salzburg Global Seminar on Global Mental Health by study. 8th Congress of Asian Sleep Research Society, Schloss Leopoldskron, Salzburg, Austria, 12 December 2014 (ii) Thiruvananthapuram, Kerala, 22-24 September 2014. Disaster psychosocial support and rehabilitation in India. 5th Asia Pacific Regional Conference on Psychosocial Rehabilitation. 121. Sathishchandra P. (i) Mechanisms of AEDS are not relevant in M.S. Ramaiah Medical College, Bengaluru, 8 February 2015. the treatment of epilepsy. 10th Asian and Oceanian Epilepsy Congress, Singapore, 7-10 August 2014 (ii) Biomarker 128. Seshagiri DV, Ravi Yadav, Arun Sasidharan, Pramod Pal, Bindu discovery and validation, translational research priorities at Kutty , Sanjeev Jain. Altered sleep architecture in autosomal NIMHANS. Inaugural Indo-US Translational Neuroscience dominant spinocerebellar ataxias: a polysomnographic based Symposium, The Johns Hopkins University, Baltimore, USA, study. World Congress on Sleep Medicine, Seoul, South Korea, 25 February-2 March 2015 (iii) International Forum on 21-25 March 2015. Promoting the Rights of Children with Mental and Intellectual Disabilities, 3rd Meeting of the Advisory Board, Gulbenkian 129. Seshagiri. Altered sleep architecture in autosomal dominant Foundation along with World Health Organization, Forum for spinocerebellar ataxias - polysomnographic based study. World child rights. (iv) Liverpool and Maastricht University Wellcome Congress on Sleep Medicine, Seoul, South Korea, 21-25 March Trust Liverpool, Glasgow Centre for Global Health Research 2015. Annual Scientific Meeting, University of Liverpool, UK, 12-20 September 2014. 130. Shabana Aboobaker, Jangam KV. Intimate partner violence and quality of life among women diagnosed with bipolar 122. Satish Girimaji (i) Genetics of intellectual disability. Indo- affective disorder: implication for psychosocial management. US Symposium on Translational Neuroscience: Biomarker State Bipolar Disorder Society, NIMHANS, Bangalore, 14 Discovery and Validation, Johns Hopkins University, Baltimore, December 2014. USA, 25 February 2015 (ii) Whole exome sequencing reveals novel mutation in PAK3 gene associated with X-linked 131. Shankaranarayana Rao BS. The everchanging brain and new Intellectual Disability (XLID). NGBT Conference, Bangalore, challenges in treating neurological and psychiatric disorders. 19 November 2014 (iii) Neurodevelopmental disorders: focus 1st IBRO/APRC Chandigarh Neuroscience School on on intellectual disability. NIMHANS – Maastricht University -Basic and Research Concepts of Depression and Cognitive Joint Workshop on Neuropsychiatry, 12-14 March 2015. Dysfunction. University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh, 2-8 November 2014 (ii) The 123. Satyanarayana VA, Prabha Chandra, Mona Duggal, Nancy everchanging brain: New challenges in treating brain disorders. Reynolds. The phoenix phenomenon: resilience in the face of International Symposium on Translational Neuroscience and multiple adversities in women with HIV in India. 6th World 32nd Annual Conference of Indian Academy of Neurosciences. Congress on Women’s Mental Health, Tokyo, Japan, 22-25 NIMHANS, Bangalore, 1-3 November 2014 (KT Shetty March 2015. Memorial Oration).
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132. Sharan S, Nalini A, Joshi NB, Joshi PG. Differential expression resonance imaging findings in a cohort of patients with POLG and functional activity of glutamate receptors and transporters related disorders: Study from a tertiary care university hospital in dorsal horn and ventral horn of spinal cord. Annual Meeting from South India. Mitochondrial Medicine 2014. United of Indian Academy of Neurosciences, NIMHANS, Bangalore, Mitochondrial Disease Foundation, Pittsburg, Pennsylvania, 1-3 November 2014. USA, June 2014.
133. Shastry AH, Balaram Thota, Kandavel Thennarasu, 140. Singh H, Reddi VS, Chandra P. Circumstances and methods Arimappamagan Arivazhagan, Vani Santosh. The Influence used for suicide attempts: are they different between of p53 expression status on the association of STAT1 and schizophrenia spectrum disorders from affective disorders. 16th MMP9 with survival in glioblastoma: from molecular biology World Congress of World Psychiatric Association, Spain, 14- towards personalized medicine. 18th International congress of 18 September 2014. neuropathology, Rio, Brazil, 14-18 September 2014. 141. Sinha S, Velmurugan J, Chaitanya G, Bharath RD, Mariyappa 134. Shayanki Lahiri Mukhopadhyay, Chetna Sharma, Veena N, Satishchandra P. Eating epilepsy and involvement of peri- Kumari H.B, Netravathi M, Sayani mazi, Nagarathna S. sylvian network: a multi-modal approach. 10th Asian & Sathishchandra P. Characterization, virulence determination Oceanian Epilepsy Congress. Singapore, 7-10 August 2014. and antifungal susceptibility profile of cryptococcus gattii from the patients of cryptococcal meningitis in a tertiary neuro- 142. Sinha S, Velmurugan J, Mariyappa N, Satishchandra P. care hospital in south India. FISF Conference, Kolkata, 14-16 Coherence and source localisation in reflex-eating epilepsy: A November 2014. MEG based analysis. 68th American Epilepsy Society, Seattle, USA 4-8 December 2014. 135. Sheshagiri DV, Yadav R, Sasidharan A, Pal P, Kutty BM, Jain S. REM sleep abnormalities in autosomal dominant 143. Sinha S. New onset status epilepticus and clusters seizures spinocerebellar ataxias. 8th Congress of Asian Sleep Research among elderly. 10th Asian and Oceanian Epilepsy Congress, Society, 22-24 September 2014, Thiruvananthapuram, Kerala Singapore, 7-10 August 2014. (Best Paper Award). 144. Sivakumar T, Chethan B, Thirthalli J, Pathak A, Ahammed A, 136. Shilpa BM, Bhagya V, Mahati K, Raju TR, Shankaranarayana Sujai R, James JW, Reddy RP, Vijayan TV, Kumar CN, Sailaxmi Rao BS. Chronic reboxetine treatment rescues cognitive Gandhi, Nirmala BP, Bhola P, Kumar D, Desai G, Chaturvedi deficits in depressive-like rats. International Symposium on SK. Caregivers support and education programme workshops: Translational Neuroscience and 32nd Annual Conference of NIMHANS experience. 5th Asia Pacific Regional Conference Indian Academy of Neurosciences. NIMHANS, Bangalore, on Psychosocial Rehabilitation, Bengaluru, 6-8 February 2015. 1-3 November 2014. 145. Sowmya Bhaskaran TS, Shekhar P Seshadri. Clinical 137. Shoba Srinath (i) Family and ASD. South Asia International characteristics of children with history of child sexual abuse Autism Conference 2015. New Delhi, 7-8 February 2015 (ii) presenting to a tertiary care centre. ICAPP 2014, Paris, France, Autism spectrum disorder. IndoUS Translational Neuroscience December 2014. Symposium. Johns Hopkins University, Baltimore, USA, 25- 26 February 2015 (iii) Broad autism phenotype. 1st Global 146. Sowmyashree Mayur Kaku. A family history study of the Conference of Biological Psychiatry. New Delhi, 27 September broad autism phenotype in the relatives of children with 2014. autism. (a) Resting state brain in autism spectrum disorders (b) Pervasive refusal syndrome–a nosological puzzle. International 138. Shruti Mathur, Manjula R, Padmanabhan B. Structure based Association for Child and Adolescent Psychiatry and Allied approach to design of inhibitors for an epigenetic marker Professions, Durban, South Africa, 11-15 August 2014. protein, BRD2. Indo-US Conference Molecular Modeling and Informatics in Drug Design, NIPER, Mohali, 3-6 November 147. Sriganesh K, Jitender Saini, Kaushik Theerth. Airway 2014. dimensions in children with neurological disability undergoing MRI study under anaesthesia. 11th SAARC AA Congress, 139. Shwetha C, Sonam K, Govindaraju C, Bindu P S, Taly AB, Kathmandu, Nepal, 26 February 2015. Gayathri N, Bharath S, Arvinda HR, Khan NA, Govindaraju P, Vandana N, Thangaraj K. Clinical, pathological and magnetic 148. Sriganesh K. Mechanisms of clinical anaesthesia-our initial
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experience. DST-Royal Society India-UK Scientific Seminar, 156. Tansa A, Jangam KV. Childhood abuse among women with NIMHANS, Bangalore, 6-9 March 2015. bipolar disorder, unipolar depression and healthy controls: a prospective study. State Bipolar Disorder Society, NIMHANS, 149. Srikala Bharath, Girish Rao. House hold cost severe mental Bangalore, 14 December 2014. illness in India – a LAMIC country. 26th World Congress of Psychiatry, Madrid, Spain, 14-18 September 2014. 157. Tewari BP, Joshi NB, Joshi PG. Astrocytic purinergic signalling modulates epileptic activity in hippocampus. Annual Meeting 150. Srikala Bharath. Popularization of neuroscience. International of Indian Academy of Neurosciences, NIMHANS, Bangalore, Symposium on Translational Neurosciences and 32nd 1-3 November 2014. Annual Conference of the Indian Academy of Neuroscience, NIMHANS, Bangalore, 3 November 2014 (ii) Empowering 158. Thirthalli J. Research in psychiatric rehabilitation: past, adolescents with life skills–a promotional approach to school present and future. 5th Asia Pacific Regional Conference on mental health program. 8th International Congress of the Psychosocial Rehabilitation organized by World Association for SAARC Psychiatric Federation, Lumbini, Nepal, 27-29 Psychosocial Rehabilitation, MS Ramaiah Hospital, Bengaluru, November 2014 (iii) (a) Mild & major neurocognitive disorders 6-8th February 2015. (b) Mental health in old age world psychiatric association. World Psychiatric Association, Regional Congress, Hong 159. Thomas Gregor Issac. (i) TMS as a Biomarker in Cortical Kong, 12-14 December 2014. Dementia. 1st International Brain Research Organization/Asia Pacific Region Conference. Chandigarh Neuroscience School. 151. Stoner LJ, Aljuma M, Birbeck G, Gururaj G, Jenson R et al. 2-9 November 2014 (ii) TMS as a biomarker to distinguish Methodological guidelines for population surveys of headache between Alzheimer’s dementia and front temporal dementia. prevalence burden and costs. European Conference on Head 17th Asia Pacific Regional Conference of Alzheimer’s disease Ache Disorders, Copenhagen, 16-20 September 2014. 7-9 November 2014, New Delhi (iii) Elevated anti-measles antibody titer-an association in autoimmune encephalitis. 3rd 152. Sudhir PM. Cognitive behaviour therapy in social anxiety International Conference on Recent Advances in Cognition disorder. International Conference on Cognitive Behavior and Health, Department of Psychology, Benares Hindu Therapy, All India Institute of Medical Sciences, New Delhi, University, Varanasi, Uttar Pradesh, 19-21 December 2014. 1-2 March 2015. 160. Uma Maheshwara Rao GS. Critical care and outcome in 153. Sunil Jamuna Tripathi, Suwarna Chakraborty, Raju TR, mechanically-ventilated patients of Guillain-barre syndrome. Shankaranarayana Rao BS. Chronic stress-induced cognitive Annual Scientific Meeting of the WTCGHR, Liverpool, UK, deficits are associated with aberrant glial morphology and 17 September 2014 (ii) The need to look beyond ICP and altered volumes of the prefrontal cortex. International CPP as markers of outcome of traumatic brain injury. Indo-US Symposium on Translational Neuroscience and 32nd Annual Translational Neuroscience symposium. Biomarker Discovery Conference of Indian Academy of Neurosciences. National and Validation. Baltimore, USA, 25-26 February 2015. Institute of Mental Health and Neuro Sciences NIMHANS, Bangalore, 1-3 November 2014. 161. Valliammal S. Attitudes of Indian mothers regarding child rights. 1st Mediterranean Interdisciplinary Forum on Social 154. Surendran D, Lakshminarayan K, Viswanath B, Purushottam Sciences and Humanities, Beirut, Lebanon. 23-26 April 2014. M, Panicker MM, Varghese M, Jain S, Joshi PG. Calcium signalling in human lymphoblastoid cell lines with different 162. Varambally S, Gangadhar BN. (i) Evidence-based yoga ApoE genotypes. Annual Meeting of Indian Academy of methods for treating depression. Network Initiative (CINI) Neurosciences, NIMHANS, Bangalore, 1-3 November 2014. 2014 Conference, Surrey, British Columbia, Canada, 19-22 June 2014 (ii) (a) Yoga for healthy aging (b) Applications of 155. Suwarna Chakraborty, Sunil Jamuna Tripathi, Raju TR, yoga in psychiatric conditions (c) Yoga for stress management. Shankaranarayana Rao BS. Chronic n-acetyl-cysteine treatment International Yoga Festival, Dubai, UAE, 30-31 January 2015. restores depression-induced behavioral deficits. International Symposium on Translational Neuroscience and 32nd Annual 163. Vasanth Kumar, Girish N, Amudhan S, Kumar R, Yadav K. Conference of Indian Academy of Neurosciences. NIMHANS, Pandav CS. Did meals outside home influence urinary iodine Bangalore, 1-3 November 2014. concentration? Results from iodine deficiency disorder resurvey
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in Kolar District, Karnataka. 2nd International Workshop National on Micronutrients and Child Health, All India Institute of Medical Sciences, New Delhi, 5 November 2014. 1. Aakriti M, Jamuna R. Rising from stroke: a single case rehabilitation study. World Asia Pacific Regional Conference 164. Venkataramanappa G, Rose Dawn Bharath. Resting state on Psychosocial Rehabilitation. MS Ramaiah Medical College, fMRI in epilepsy diagnosis. 18th International Conference Bangalore, 6-8 February 2015. of International Society of Radiographers and Radiological Technologists, Helsinki, Finland, 12-15 June 2014. 2. Abdul Basith. MRI safety. National Conference of the Indian Society of Radiographers & Technologists, Kovalam, 165. Venkataramanappa G, Rose Dawn Bharath. Utility functional Trivandrum, Kerala, 13-14 December 2014. MRI in patients with brain tumor. South East Asia MRI Workshop organized by National University of Singapore, 3. Aboobaker S, Jangam K, Muralidharan K. Intimate partner Biopolis, Singapore, 17-18 January 2015. violence and quality of life among women diagnosed with bipolar disorder: implication for psychosocial management. 5th 166. Venkatasubramanian G, Bose A, Agarwal SM, Chhabra H, Annual Conference of the Society for Bipolar Disorders–India, Shivakumar V, Shenoy S, Dinakaran D, Narayanaswamy SBDI 2014, Bangalore, 14 December 2014. JC. Clinical utility of add-on tdcs in schizophrenia: an open label study of 50 patients. 1st International Brain 4. Adhin Bhaskar, Thennarasu K, Janardhana Reddy YC. Stimulation Conference, Singapore, 2-4 March 2015 (ii) Prediction of number of psychiatric co-morbidities among Clinical & neurobiological studies on transcranial direct obsessive compulsive disorder patients using regression current stimulation for schizophrenia: Indian experience. 1st approach. ISMS 2014, University of Jammu, Jammu, 1-3 International Brain Stimulation Conference, Singapore, 2-4 November 2014. March 2015. 5. Ahammed A, Pathak A, Chethan B, Sujai R, James JW, Reddy 167. Vikas Dhiman, Sinha S, Arivazhagan A, Mahadevan A, Bharath RP, Vijayan TV, Sivakumar T, Kumar CN, Gandhi S, Nirmala RD, Saini J, Jamuna R, Rao MB, Shankar SK, Satishchandra BP, Bhola P, Kumar D, Desai G, Thirthalli J, Chaturvedi P. Predictors of spontaneous seizure remission in patients of SK. Rehabilitation in a person with borderline intellectual medically refractory epilepsy due to mesial temporal sclerosis function: a case report. 5th Asia Pacific Regional Conference (MTS). 10th Asian Oceanian Epilepsy Congress in Singapore, on Psychosocial Rehabilitation, Bengaluru, 6-8 February 2015 7-10 August, 2014. (Best Poster Award).
168. Vikas Dhiman. Case presentation (EEG in SSPE). 2nd 6. Akhil Deepika, Dhaval P Shukla, Sathyaprabha TN, Dianalund Summer School on EEG and Epilepsy, Dianalund, Indira Devi B. Demonstration of the subclinical autonomic Denmark,13-19 July 2014 dysfunction following severe traumatic brain injury using serial heart rate variability monitoring: a pilot study. 1st TS 169. Vivek Benegal. Rehabilitation for substance use disorders: need Srinivasan-NIMHANS Knowledge Conclave on Autonomic to change mindsets and strategies. 5th Asia Pacific Regional Dysfunction, NIMHANS, Bangalore, 12-13 February 2015. Conference on Psychosocial Rehabilitation, Bangalore, February 2015 (ii) Social change, mental health, alcohol misuse 7. Alfiya JS, Betsy Aabu, Ravi GS, Meera SS, Shivashankar N. and masculinity. International Symposium on Masculinities- Autism spectrum disorders-understanding parental pursuit to Men Engage, New Delhi, November 2014 (iii) Harms to access speech language services in the Indian context. 47th others from alcohol use in India. WHO-Thai Health Meeting ISHACON, Manipal, 1-3 January 2015. on Harms to Others, Torino, June 2014. 8. Amey Sarvardekar. External ventricular drainage and lumbar 170. Vrinda M, Arun S, Kala P Nair, Bindu M Kutty, drainage: procedure and care. 7th NSI Educational Course, Shankaranarayana Rao BS. Levetiracetam decreases seizure NIMHANS, Bangalore, 31 January– 1 February 2015. frequency and ameliorates temporal lobe epilepsy induced cognitive deficits. International Symposium on Translational 9. Amitha Raj. Diffusion weighted imaging in multiple sclerosis. Neuroscience and 32nd Annual Conference of Indian Academy National Conference of the Indian Society of Radiographers & of Neurosciences. NIMHANS, Bangalore, 1-3 November Technologists, Kovalam, Trivandrum, Kerala, 13-14 December 2014. 2014.
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10. Amrutha Issac. Digital subtraction angiography (DSA). Society (Nagpur), Nagpur, 3 July 2014 (xx) Meta-analysis National Conference of the Indian Society of Radiographers & made simple: How to understand everything that you read in Technologists, Kovalam, Trivandrum, Kerala, 13-14 December a paper on meta-analysis. Workshop on Medical Education 2014. Technology Cell, NKP Salve Medical College, Nagpur, 4 July 2014 (xxi) Psychopharmacological management of anxiety and 11. Andrade C (i) Drug interactions in Consultation Liaison somatoform disorders. Sion Hospital, Bombay, 5 July 2014 Psychiatry Workshop. Mid-term CME of Indian Psychiatric (xxii) Electrical stimulation of the human brain: clinical and Society (South Zone), Kovalam, 10-11 May 2014 (ii) basic science findings. HJ Mehta Oration. St. John’s National Management of schizophrenia: towards pharmacological Academy of Health Sciences, Bangalore, 11 July 2014 (xxiii) holisticness. 2nd National CME on The Unique Journey Newer treatments in schizophrenia. Indore Psychiatric of the Serotonin-Dopamine Stabilizer, Behavioral and Society, Indore, 07 November 2014 (xxiv) Newer treatment Neuroscience Academy of India, Madras, 29 June 2014 (iii) options in schizophrenia. Delhi Psychiatric Society, New Cognitive reserve and lifestyle modification towards reducing Delhi, 8 November 2014 (xxv) (a) Time release formulations the risk of Alzheimer’s disease-Neurobiological model. Annual in psychiatry and formulations of Valproate: How and why Conference of the Indian Psychiatric Society, Bhimavaram, these affect clinical practice. (b) Aripiprazole augmentation Andhra Pradesh, 12-13 July 2014 (iv) Medical concerns in the in schizophrenia: Benefits in refractory and nonrefractory use of antidepressants in patients with medical disease. CME on patients. (c) Benefits of Valproate beyond bipolar disorder: Psychosomatic Medicine. PsyCon 2014, Fr Muller’s Hospital, Indications for clinical practice (d) Use of Aripiprazole in major Mangalore, 20 July 2014 (v) Management of schizophrenia. depressive disorder: Benefits during acute and maintenance 6th National CME on The Unique Journey of the Serotonin- therapy (e) Use of Aripiprazole in bipolar disorder: Benefits Dopamine Stabilizer, Behavioral and Neuroscience Academy during acute and maintenance therapy. National Workshop on of India, Nagpur, 24 August 2014 (vi) Intranasal drug delivery Psychopharmacology, Goa, 22 November 2014 (xxvi) (a) SSRIs in neuropsychiatry. 47th Annual Conference of the Indian in ischemic heart disease: benefits and risks. (b) Intranasal Psychiatric Society, South Zone, Bangalore, 17-19 October 2014 treatments in neuropsychiatry for the practicing clinician CME. (vii) ECT: myths and realities. 23rd Annual Conference of the Vidarbha Psychiatric Association, Nagpur, 23 November 2014 Indian Medical Association, Kalyan, Bombay, 6-7 December (xxvii) Augmentation strategies in depression. CME. Indian 2014 (viii)Aripiprazole augmentation in schizophrenia. National Psychiatric Society, Nasik, 13 December 2014 (xxviii) Advances CME on Serotonin-Dopamine Stabilization, Behavioral and in the psychopharmacology of schizophrenia. Coimbatore Neuroscience Academy of India, Ahmedabad, 28 December Psychiatric Society, Coimbatore, 20 December 2014 (xxix) 2014 (ix) Serotonin-dopamine stabilization in schizophrenia. Newer treatment options for schizophrenia: Blonanserin. Workshop on Serotonin-Dopamine Stabilization, Behavioral Hyderabad Psychiatric Society, Hyderabad, 21 December and Neuroscience Academy of India, Guwahati, 01 February 2014 (xxx) Understanding neuroplasticity as a mechanism of 2015 (x) How to read and understand a paper on meta-analysis. antidepressant action. Dr. UK Sheth Oration, GS Seth Medical CME Workshop. Kerala State Psychiatric Society PG CME, College and King Edward Memorial Hospital, Bombay, 21 Trichur, 22 February 2015 (xi) (a) Psychopharmacology of January 2015 (xxxi) Antipsychotic augmentation treatments anxiety. Lucknow, 5 April 2014 (b) Tofisopam in anxiety. 6 for schizophrenia. Postgraduate CME, Masina Hospital, April 2014, Kanpur.Indian Psychiatric Society, Central Zone, Bombay, 31 January 2015 (xxxii) Aripiprazole augmentation Indian Psychiatric Society, Central Zone (xii) Augmentation for schizophrenia. Symposium on Psychopharmacology, strategies in schizophrenia. Indian Psychiatric Society, 12 Behavioral and Neurosciences Academy of India, Guwahati, 01 April 2014, Trichur (xiv) Recognizing mental disturbances in February 2015 (xxxiii) Psychopharmacological augmentation students. Faculty Development Program, CB Bhandari Jain strategies for schizophrenia. Symposium on Serotonin- College, Bangalore, 29 April 2014 (xv) Opipramol for anxiety Dopamine Stabilizers, Behavioral and Neurosciences and somatoform disorders. CME. Salem Psychiatric Society, Academy of India, Trichur, 15 February 2015 (xxxiv) Salem, 3 May 2014 (xvi) Newer trends in psychopharmacology. Innovative psychopharmacological augmentation strategies for Indian Psychiatric Society (Pune), 14 June 2014 (xvii) schizophrenia. 15th Annual National Conference of Indian Clobazam in psychiatry. Guwahati Medical College, Association of Private Psychiatry, Cochin, 13-16 November Guwahati, 27 June 2014 (xviii) Syndromal and symptomatic 2014 (xxxv) The story of cognitive reserve in neuropsychiatry. anxiety: neurobiological correlates and management. Indian Indian Psychiatric Society (Amravati), Amravati, 28 February Psychiatric Society (West Bengal) and Indian Association of 2015 (xxxvi) Augmentation strategies in schizophrenia and Private Psychiatrists (West Bengal), Calcutta, 28 June 2014 update on newer antipsychotics. Indian Psychiatric Society (xix) Current role of clobazam in psychiatry. Indian Psychiatric (West Bengal), Calcutta, 12 March 2015 (xxxvii) Update
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on Blonanserin. Guwahati Psychiatric Society, Guwahati, Seminar on Women in Science, IISc, Bangalore, 3-5 February 13 March 2015 (xxxviii) Antipsychotic augmentation for 2015. schizophrenia. Workshop on Psychopharmacology, Behavioral and Neurosciences Academy of India, Ludhiana, 15 March 15. Antony S, Thomas B, Dhanasekarapandian R. (i) Lobbying 2015 (xxxix) Blonanserin. Calicut Psychiatrists’ Guild, Calicut, and negotiation for patients welfare, National Conference 21 March 2015. of Almoners, Department of Medical Social Work, Amala Institute of Medical Sciences, Thrissur, Kerala, 10 February 12. Anita Mahadevan (i) Destination brain: games viruses play. 2015 (ii) Impact of community based interventions on Post-graduate training program. St John’s medical College, perception of parental stress, resilience and resources by parents Bangalore, 9 of June 2014 (ii) Pituitary involvement in rabies of children with developmental disorder. 33rd Annual National viral encephalitis? 16th National Conference of Association for Conference of Indian Society of Professional Social Work, Prevention and Control of Rabies in India, Mysore, 5-6 July Bharathiyar University, Coimbatore, 28-30 January 2015. 2014 (iii) Players, patterns and pathology in CNS infections? CME in Pathology, Rajarajeshwari Medical College & Hospital, 16. Aravind Raj E, Sekar K (i) Economic and psychological impact Bangalore, 26 July 2014 (iv) Pre-conference CME in Advances on families dependent on coir industry in tsunami affected in Neurology. 63rd Annual Conference of Neurological Society areas in Tamil Nadu. Regional Conference on Science and of India-NSICON 2014, Coimbatore, 12-15 December 2014 Technology for Disaster Management Jointly organized by (v) Microscopic anatomy of the brain with emphasis on special Karnataka Science and Technology Academy and School of stain. CME in Cross Sectional Anatomy of Brain and its Earth Science, Central University of Karnataka, Gulbarga. Dr. Applied Aspects MVJ Medical College & Research Hospital, SM. Pandit Rangamandir, Kalaburagi, 22-23 January 2015 (ii) Hosakote, Bangalore, 23 September 2014 (vi) Infections of Symposium on Rehabilitation at the Sakalawara Community central nervous system- the bugs versus beast. CME Program Mental Health Center using a Multidisciplinary Approach. in Neuropathology, Department of Neurosurgery PG Teaching 67th Annual National Conference of Indian Psychiatric Society, series, Bangalore Medical College and Research Institute, Hyderabad, 8-11 January 2015 (iii) Harmonizing personal, Bangalore, 12 October 2014 (vii) Human brain–the inside story. familial and professional life. National Conference on Inclusive Popularization of Neuroscience. International Symposium on and Sustainable Growth for Emerging Economies like India. Translational Neuroscience & 32nd Annual Conference of the T. John’s Institute of Management and Science, Bangalore, 9 Indian Academy of Neurosciences, 1-3 November 2014 (viii) December 2014. (a) Reviving a dying science. Role of autopsies in learning pathology (b) CNS infections. Department of Pathology, PSG 17. Aravind Raj E, Sekar K, Grace Henry, Kavita Jangam. Health Institute of Medical Sciences & Research, 12 December 2014 status of Tibetan women in India. 32nd Annual National (ix) Pathology Discussant. Clinicopathologic Conference. Conference of ISPSW. KSWU, Bijapur, 20-22 January 2014. Joint Annual Conference of the IEA and IES-ECON 2015, Chennai, 6-8 February 2015 (x) Squash cytology of CNS 18. Arivazhagan A (i) Novel genes and gene signature in tumors, IAC KC-CON 2015, Bellary, 14-15 February 2015 prognostication of glioblastoma: potential targets and pathway (xi) Pathology of refractory epilepsy. Epilepsy Symposium. identification. 6th Annual Conference of the Indian Society KNACON 2015, Mangalore, 21-22 February 2015 (xii) of Neuro-oncology, Lucknow, 11-13 April 2014 (ii) Cortical/ Neurobiology of epilepsy. NIMHANS–Maastricht University sulcal neuro anatomy for the neuro oncological surgeon to Joint Workshop on Neuropsychiatry, NIMHANS, Bangalore, maximise resections. Pre-Conference Workshop. 7th Annual 12-14 March 2015 (xiii) Pitfalls and problems in stereotactic Conference of the Indian Society of Neuro-oncology, biopsies. NSI Conference, Cochin, 26 March 2015. Cochin, 26 March 2015 (iii) Surgery for acute stroke, CME on Interventions in Stroke, IMA, Pondicherry Chapter and 13. Anshu K, Kumaresan UD, Ajay KN, Bindu MK, Shoba S, PANS, Pondicherry, 29 June 2014 (iv) Management of multi- Laxmi TR. Altered attentional abilities in a rat model of compartmental hydrocephalus. 25th Annual Conference of autism spectrum disorder. 32nd Annual Conference of Indian Indian Society for Pediatric Neurosurgery, IndSPNCON Academy of Neurosciences. Bangalore, 1-3 November 2014. 2014, Bhubaneshwar, Orissa, 18-19 October 2014 (v) How I do It: Video demonstration of awake craniotomy and 14. Anshu K, Kumaresan UD, Ajay KN, Bindu MK, Shoba S, functional mapping. 2nd Bi-Annual CME of Indian Society Laxmi TR. Rat model of autism induced by prenatal Valproate of Stereotactic and Functional Neurosurgery, NIMHANS, exposure: evaluation of attentional abilities. Indo-French Bangalore, 27-28 September 2014.
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19. Arthur JAJ, Dhanasekarapandian R. Reasons for drinking after November 2014 (vii) Update on the current status of nitrous abstinence. 33rd Annual National Conference of the Indian oxide. 6th Annual Conference of the Indian College of Society of Professional Social Work, Bharathiyar University, Anaesthesiologists, Narayana Hrudayalaya, Bengaluru, 21-23 Coimbatore, Tamil Nadu, 28-30 January 2015. November 2014 (viii) Panel Discussion – What perioperative management strategies improve outcome in head injuries. 20. Ashwathnarayana DH, Madhusudana SN, Ravish HS et al. ISACON 2014, Madurai, 26-29 December 2014 (ix) Moderated Safety and immunogenicity of a shortened one week regimen a Panel Discussion on Traumatic Brain injury conducted by with cell culture rabies vaccines for post-exposure prophylaxis. NIMHANS, 18 January 2015 (x) Brain monitoring in head 16th National Conference of the Association for Prevention injuries,16th Annual Conference of the Indian Society of and Control of Rabies in India, Mysore, 5-6 July 2014. Anaesthesiologists and Critical Care. Lucknow, 29 January-1 February 2015 (xi) Anaesthesia for posterior fossa tumors. 21. Ashwin YB, Basavaraj GV, Reeta Mani, Madhusudana SN. RACE 2015, Chennai, 6-8 February 2015 (xii) Monitoring Fatal paralytic form of rabies encephalitis after a cat bite: A the central nervous system. CME SANCON 2015 and also case report with comprehensive laboratory confirmation of conducted a Workshop on Depth of Anaesthesia Monitoring. the clinical suspicion. 4th Annual Conference of the Clinical Sri Sathya Sai Institute of Higher Medical Sciences, 14-15 Infectious Diseases Society, Bangalore, 22-24 August 2014. March 2015.
22. Ashwini MA, Reeta Mani, Ashwin YB, Madhusudana SN. 27. Bhagya V, Shankaranarayana Rao BS. Therapeutic interventions Human rabies cases in India: A laboratory perspective.16th to ameliorate depression-induced cognitive deficits. 1st National Conference of the Association for Prevention and National Conference of Association of Physiologists of India Control of Rabies in India (APCRICON), Mysore, 5-6 July on a Theme-Physiology in 21st Century: Contributions to 2014. Clinical Medicine. JIPMER, Puducherry, 15-19 December 23. Ashwini MA, Reeta Mani, Shilpa KA, Manjunath V, Ravi V. 2014. Evaluation of a commercial kit of Real time polymerase chain reaction for early diagnosis of Dengue. Annual Conference of 28. Bhagyalakshmi Shankarappa, Anirrudh Basu, Shwetha the Indian Association of Medical Microbiologists, Jaipur, 15- Byrappa, Rashmi Chandra, Sandeep Kandregalu, Biju 19 October 2014. Viswanath, Sanjeev Jain, Pratima Murthy, Meera Purushottam. Whole genome methylation and mthfr (c677t) polymorphism 24. Atulya G, Jamuna R, Chandra R, Divya S. Forgetting to in alcohol dependence. 67th Annual National Conference of remember: cognitive profile of a patient with dementia: case the Indian Psychiatric Society, 11 January 2015. study. National Conference on Cognitive and Neuropsychology: Challenges and Issues, Christ University, Bangalore, 14-15 29. Bharath MMS (i) Role of mitochondrial damage and oxidative November 2014. stress in muscle degeneration: Implications for human neuromuscular disorders. Biochemical society, Department of 25. Balakrishnan A, Mittal S, Ray A, Girimaji SC. Bleeding per Biochemistry, University of Mysore, Mysore, 10 November rectum after starting of lithium therapy in a case of Bipolar 2014 (ii) Therapeutic potential of natural products in Disorder. 5th Annual Conference for Society of Bipolar Parkinson’s disease. Neuroupdate-2014, Indian Institute of Disorder, Bangalore, 14 December 2014. Chemical Biology, Kolkata, 2014.
26. Bhadrinarayan V (i) CME on Post Graduate Teaching 30. Bhat MD, Bindu PS, Netravathi M, Madhu N, Gupta AK, Conclave in Neuroanaesthesia and Critical Care, Kolkatta, 7 Christopher R. Imaging spectrum of peroxisomal disorders- June 2014 (ii) Monitoring depth of anaesthesia. 30th Annual an Institutional study. 68th Annual Conference of Indian South Zone Conference, Visakhapatnam, 22-24 August 2014 Radiological & Imaging Association, Kochi, 29 January-1 (iii) Anaesthesia for neuroradiology. CME conducted by Fortis February 2015. Hospital, 29 August 2014 (iv) Moderated the Panel Discussion on Monitoring the Ischemic Brain. NEUROVASCON 31. Bhola P (i) Social skills assessment; Social skills training role 2014, NIMHANS, 5 September 2014 (v) Multicompartment play sessions; Work-related social skills training. Workshop management of patients with traumatic brain injury. Annual on Psychological Interventions in Schizophrenia: Social Skills Karnataka State Anaesthesia Conference, Dharwad, 10- 2 Training and Metacognitive Therapy in Recovery-Oriented October 2014 (vi) Raised ICP and its management. CME Practice. 21 February 2015 (ii) Stick to your values: therapist Anaesthesia Touching Various Specialties, Mandya, 12 values and beliefs; Values and value conflicts in the therapy
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room; Working through value differences. Workshop on neuroscience & consciousness. Brain Storming Symposium on Personal Values in the Therapy Room. NCWB, Bangalore, 17 Consciousness, NIAS, Bangalore, 11-12 December 2014 (vi) January 2015 (iii) Digital ethics; ethical decision making. Social (a) Neurophysiology of sleep (b) Neural plasticity and cognition media policy: Individual and institutional. Workshop on Digital ASSOPICON 2014, JIPMER Pondicherry, 15-19 December Ethics: The Internet and Digital Ethics: New Challenges for 2014. Practitioners and Clients. 5th National Bioethics Conference, St. John’s Medical College Hospital, Bangalore, 13 December 34. Bindu PS (i) Metabolic Epilepsies. 3rd IAN Post Graduate 2014 (iv) Social skills assessment; Social skills training case Summer Course in Neurology, April 2014 (ii) Disorders in scenarios; Work-related social skills training. Workshop on children. Conference & CME, IAP, Bangalore, June 2014 (iii) Social Skills Training in Clinical Workshop on Cognitive Mitochondrial disorders, an overview. Hands on Workshop Assessment and Remediation. Psychiatry Update 2014. in Neurochemistry and Electron microscopy, Bangalore, July Kasturba Medical College, Manipal, 16 November 2014 (v) 2014 (iv) Overview of neurometabolic disorders. NIMHANS Locating our personal and professional selves; Integrating self- – Maastricht University Joint Workshop on Neurosciences, reflection in practice; Internal audit: Integrating into practice. Bangalore, March 2015. Workshop on Mirror, Mirror on the Wall: Becoming a Self- Reflective Practitioner. NCWB, Bangalore, 22 September 35. Binukumar B, Deepa M, Grace M, Pradeepa R, Roopa S, 2014 (vi) Self injury: defining the problem; assessment of self- Khan HM, Fatmi Z, Kadir MM, Naeem I, Ajay VS, Anjana injurious behavior; Interventions for self-injurious behavior; RM, Ali MK, Prabhakaran D, Tandon N, Mohan V, Narayan Targeting self-injury in schools and colleges. Workshop on KMV. For the CARRS surveillance research group. Do the risk Self-Injurious Behaviours: Awareness, Understanding and factors for diabetes in urban South Asians vary in complete Assessment. NCWB, Bangalore, 6 September, 2014 (vii) cases analysis compared to multiple imputation using chained Problems of adolescence. Prasanna Counselling Centre. equations? Sovenir, Annual Conference of the Kerala Statistical Bangalore, 20 September 2014 (viii) Frames or fences? Association, Thrissur, Kerala, 9-10 January 2015. Working in a multidisciplinary team. Panel on Integration of Professional Boundaries in Multidisciplinary Approaches in 36. Birudu Raju, Reddy NK, Paritosh Pandey, Vani Santosh. Mental Health Care; Challenges and Opportunities, Christ Impact of psychosocial interventions on psychosocial needs of University, Bangalore, 10 September, 2014 (ix) Recovery persons with glioblastoma. 33rd Annual National Conference oriented services: assessment and documentation. Sensitisation of the Indian Society of Professional Social Work, Bharathiyar Programme on Psychiatric Rehabilitation. St. Anne’s Degree University, Coimbatore, Tamil Nadu, 28-30 January, 2015. College for Women, Bangalore, 5 August 2014 (x) Ethics in psychotherapy; ethical dilemma case scenarios; ethical decision 37. Birudu Raju, Reddy NK. The unmet psychosocial needs of making. Workshop on Ethical Practice in Psychotherapy in family care givers of persons with brain tumors-A qualitative the National Workshop in Psychotherapy Practice in Medical study. Emerging Health Issues across Life Stages, University of and Psychiatric Social Work Setting. Department of Psychiatric Mysore, Mysore, 6-7 March 2014. Social Work, NIMHANS, 31 July 2014. 38. Cassandra S, Jamuna R. Aftermath of TBI: the role of nature 32. Bhola P, Sinha A, Sonkar S, Raguram R. Ethical dilemmas – nurture reciprocity in rehabilitation. National Conference on experienced by clinical psychology trainee therapists. 5th Cognitive and Neuropsychology: Challenges and Issues, Christ National Bioethics Conference, Bangalore, 11 December 2014. University, Bangalore, 14-15 November 2014.
33. Bindu M Kutty (i) Current understanding on the neurobiology 39. Chaitanya G, Santhosh NS, Ravi GS, Sanjib S, Thennarasu K, of sleep and wakefulness. CME on Brain and Cognitive Arivazhagan, Anitha M, Bharath R D, Jitender Saini, Jamuna Functions, JNMC, Belgaum, 20 August 2014 (ii) Human sleep R, Keshav M, Rao MB, Satishchandra P. (i) Circadian rhythm organization: a window to assess brain functions from illness and awake/sleep patterns of seizures in patients with temporal to wellness. 32nd Annual Conference of the Indian Academy lobe epilepsy. (ii) Predictors of secondarily generalized seizures of Neuroscience, NIMHANS, Bangalore, 1-3 November in EMU in patients with temporal lobe epilepsy. National 2014 (iii) Neurophysiology of cognition/ neuronal plasticity. Epilepsy Conference-2015, Chennai, 6-8 February 2015. National Conference on Cognitive and Neuropsychology: Challenges and Issues, Christ University, Bangalore, 14- 40. Chaitra C, Reddy NK. An intervention study on decision 15 November 2014 (iv) Physiology of sleep, CME- Sleep making and self esteem among institutionalized adolescent and Sleep Disorders, Puri, 19 November 2014 (v)Meditation, girls. Emerging Trends in Social Work Education. 33rd Annual
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National Conference of the Indian Society of Professional Base Surgery Society of India 2014, JIPMER, Puducherry, Social Work, Bharathiyar University, Coimbatore, Tamil Nadu, 9-12 October 2014 (ii) Imaging posterior fossa tumors; what is 28-30 January 2015. new. Neurological Society of India 2014. Annual Conference, Coimbatore, 12-15 December 2014 (iii) Transverse sinus 41. Chakrabarti D, Ramesh VJ, Pendharkar H. Endovascular coil stenting in IIH- review of 15 cases. IRIA 2015. Kochi, 20-31 detachment causing EMG artefact in BIS-A mechanistic January 2015 (iv) Pediatric metabolic disorder. Symposium on exploration. 16th Annual Conference of Indian Society Advanced MR Imaging Techniques with Focus in Pediatrics. of Neuroanaesthesiology and Critical Care, Lucknow, 30 Fortis Hospital, Gurgaon, 27 February-1 March 2015. January-1 February 2015. (1st Prize for Poster Presentation) 46. Chandrasekhar Sagar BK. Transmission electron microscopy 42. Chakradhar N, Kulkarni Girish Baburao, Pawanraj PI, Kulkarni and its applications in biological and medical sciences. PG Advaith Prakash, Chandrajit Prasad, Mustare Veerendrakumar. Special Lecture Series in Life Sciences, Mangalore University, Clinico-radiological profiles of lateral medullary (Wallenberg’s) Mangalore, 28-30 October 2014. (LMS) syndrome patients from stroke unit of NIMHANS, a tertiary care neurological hospital from Bangalore. 22nd 47. Chaturvedi SK (i) Recovery oriented services: obstacle is Annual Conference of the Indian Academy of Neurology, PGI the path. ICONS SCARF, Chennai, 21-23 August 2014 Chandigarh, 6-9 November 2014. (ii) Neuropsychiatric aspects of brain tumors CME on Neuropsychiatry, Kolkatta, 4-5 September 2014 (iii)Delivered 43. Chand PK (i) Behavioural addiction. South zone CME Keynote address on Psycho oncology.CME on Consultation of Indian Psychiatry Society, Udupi, 17 August 2014 (ii) Liaison Psychiatry, AFMC, Pune, 7 September 2014 (iv) Addiction: beyond reward pathway.1st Global Conference of Diabetes and Depression. Biocon Conference on Diabetes, Biological Psychiatry, New Delhi, 25-29 September 2014 (iii) Bangalore, 9 November 2014 (v) Evidence based practices Understanding addiction. CME, Hyderabad, 8 February 2015 in psychiatric rehabilitation services: are they relevant? Asia (iv) Technology in psychiatry education: virtual knowledge Pacific Psychosocial Rehabilitation Conference, Bangalore, 6-8 network NIMHANS. Indian Psychiatry Society South zone February 2015. Conference, 19 October 2015 (v) Cannabis: an overview. Virtual Knowledge Network NIMHANS ECHO Cannabis 48. Chethan B, Waghmare A, Thirthalli J, Sivakumar T, Kumar CN, Addiction Module, Bangalore, 7 October 2014 (vi) (a) Tobacco: Gandhi S, Nirmala BP, Bhola P, Kumar D, Desai G, Thirthalli Why Quit. 3 March 2015(b) Pharmacotherapy of tobacco J, Chaturvedi SK. Supported education for a client with mental dependence. Virtual Knowledge Network NIMHANS ECHO illness at psychiatric rehabilitation services, NIMHANS: a case Tobacco addiction module, Bangalore 31 March 2015 (vii) report. 21st National Conference Indian Association for Social Opioid use disorders: an overview. Virtual knowledge network Psychiatry, Mysore, 21-23 November 2014. NIMHANS echo opioid use disorders and its management module. Bangalore, 31 March 2015. 49. Chetna Sharma, Shayanki Lahiri Mukhopadhyay, Netravathi, Veenakumari HB, Sayani Maji, Nagarathna S, Sathishchandra. 44. Chandra SR (i) Choosing antiepileptics rationally, Calicut, Antifungal susceptibility profile of cryptococcus neoformans 22 June 2014 (ii) Human body as a complex system, An complex isolated from patients of cryptococcal meningitis in Interdisciplinary Symposium, Bangalore, 12 August 2014 (iii) a tertiary neuro-care hospital in south India. IAMM (KC) Clinical approach to early diagnosis and treatment of Alzheimer’s Conference, Bangalore, 20 December 2014. disease. World Alzheimer Month CME, NIMHANS, Bangalore, 18 September 2014 (iv) Karnataka Chapter, 30th 50. Chinnadurai, Thirumoorthy A, Arthur J. Physical and CME of MERT-API, Bangalore, 16 October 2014 (v) (a) Mirror psychological impact on social networking sites on adults-a agnosia and mirror image agnosia in patients with dementia (b) prospective study. 33rd Annual National Conference of the Role of TMS as an early biomarker in cortical dementias, APRC Indian Society of Professional Social Work, Bharathiyar Conference, New Delhi, 7-8 November 2014(v) NSI Kerala University, Coimbatore, Tamil Nadu, 28-30 January 2015. Chapter, Neuropsychological Seminar, Trivandrum, 20 February 2015 (vii) Chairperson, Joint workshop on Neuropsychiatry, 51. Christopher R (i) Tandem mass spectrometry: application in NIMHANS, Bangalore, 13 March 2015. clinical diagnosis. CME in Biochemistry, Kamineni Institute of Medical Sciences, Nalgonda, Telengana, 11 March 2015 (ii) 45. Chandrajit Prasad (i) Pre-operative embolisation of skull base Utility of tandem mass spectrometry in screening for inborn and head & neck tumors. 16th Annual Conference of the Skull errors of metabolism. CME on Good Clinical Laboratory
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Practices, Mysore Medical College and Research Institute, Symposium on Neurocognitive Rehabilitation, National Mysore, 17 March 2015 (iii) Tandem mass spectrometry: a tool Conference on Cognitive & Neuropsychology: Challenges & for identification of neurometabolic disorders. NIMHANS- Issues, Christ University, Bangalore, 14-15 November 2014. Maastricht University Joint Workshop on Neuropsychiatry, NIMHANS, Bangalore, 12-14 March 2015. 60. Dhanya P, Reddy NK, Nupur P. Psychosocial issues of family care givers of persons with spinal cord injury-a review. 33rd 52. Desai A. Quality assurance: The NRL perspective. NACO- Annual National Conference of the Indian Society of PCI Meet, New Delhi, 3-4 December 2014. Professional Social Work, Bharathiyar University, Coimbatore, Tamil Nadu, 28-30 January 2015. 53. Desai G (i) Risk assessment in perinatal psychiatry, Foundation day CME, KGMC, Lucknow, 19 March 2015. 61. Dhaval P. Shukla (i) Comparison of predictability of Marshall and Rotterdam grading system in determining mortality after 54. Devasthali G, Chandra PS, Vidyendran, Thippeswamy traumatic brain injury. Annual Conference of Neurotrauma H, Desai G, Malavika R. Pregnancy and fetal outcomes in Society of India, Mossoro, 2014 (ii) Outcome measures for women exposed to lithium during pregnancy–a naturalistic traumatic brain injury. Annual Conference of Neurotrauma prospective study. 5thAnnual Conference of the Society Society of India, Missouri, 2014 (iii) Radiosurgery for for Bipolar Disorders-India, NIMHANS, Bangalore, cerebral metastasis. Moderated a Panel Discussion during 14 December 2014. STEREOCON CME, Bangalore, 2014 (iv) (a) Neuroimaging in mild TBI (b) Autonomic dysfunction in TBI. AIIMS Annual 55. Dhananjaya I Bhat, Shukla D, Mahadevan A, Sharath N, Neurotrauma Conference, New Delhi, 2014 (v) Surgical Reddy APJ. Validation of a blast induced neurotrauma model management of DACA aneurysms. Annual Conference of using modified Reddy tube in rats: a pilot study. 23rd Annual Neurological Surgeons Society of India, Indore, 2015 (vi) Conference of Neurotrauma Society of India, Mussorie, Cervical spondyloptosis. Annual Conference of Neurotrauma Uttarakhand, August 2014 (Best Poster Award). Society of India, Mussorie, 2014 (Best Poster Award) (vii) Photo-atlas of inner skull base using DSLR camera. Annual 56. Dhananjaya I Bhat. Clinical discussant of problem based case of Conference of Skull Base Surgery Society of India, Pondichery, vestibular schwannoma for gamma knife. 2nd Biannual CME 2014 (Best Poster Award) (viii) Suprabrow craniotomy in Stereocon organized by NIMHANS, Bangalore during for aneurysms. Annual Conference of Indian Society of September 2014. Cerebrovascular Surgery, Bangalore, 2014.
57. Dhanasekarapandian R, Arthur JAJ. National Seminar on 62. Dipendu Das, Hari Namboodri, Aravind Kumar, Saranyaa G, Social Work Practice: Scope and Challenges in the Present Sharon Prathana. Vestibular function in children with cochlear Context, Department of Social Work, Kurukshetra University, implants–A pilot study, Proceedings of the 12th Annual Kurukshetra, Haryana State, 14-15 November 2014. Conference of the Cochlear Implant Group of India, Delhi, December 2014. 58. Dhanasekarapandian R, Soyus J. Workshop on Psycho- educational Skills for Teachers of Higher Education, 63. Dwarakanath Srinivas (i) Clinoidectomy techniques. Annual Department of Social Work, Bharathidasan University, Conference of Cerebrovascular Society of India, Bangalore, Tiruchirappalli, Tamil Nadu State, 31 October 2014. 4-7 September 2014 (ii) Multicompartmental trigeminal schwannomas – management strategies. Annual Conference 59. Dhanya C, Kumar KJ (i) Cognitive rehabilitation in hypoxic of Skull Base Society of India, Pondicherry, 10-12 October brain injury sequelae: a single case study. WFNR Workshop 2014 (ii) Craniosynostosis – outcomes. Annual Conference of on Neuropsychological Rehabilitation, Chennai, 29-31 August Indian Society of Pediatric Neurosurgery, Bhubaneswar, 16-19 2014 (ii) Executive functioning in mild cognitive impairment: October 2014 (iv) Management guidelines in pediatric head three case studies. 5th Asia Pacific Regional Conference on injuries. AIIMS Annual Neurotrauma Conference, New Delhi, Psychosocial Rehabilitation. MS Ramaiah Medical College, 1-2 November 2014 Bangalore, 6-8 February 2015 (iii) Finding the mind in the brain: an interplay of neuropsychological rehabilitation and 64. Fahim U Hassan, Birudu Raju, Misha T, Reddy NK. A social affective neuroscience, Symposium on Neuro-Cognitive preliminary study on distress and psychosocial wellbeing of Rehabilitation, Christ University, Bangalore, 14-15 November persons with brain tumors in post surgical phase. 33rd Annual 2015 (iv) Intervention for social cognition for schizophrenia. National Conference of the Indian Society of Professional
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Social Work, Bharathiyar University, Coimbatore, Tamil Nadu, pial arteriovenous fistulae: single centre experience with 28-30 January 2015. endovascular treatment. Neurovascon 2014, NIMHANS, 5-7 September 2014. 65. Gandhi S. Importance & goals in rehabilitation. Workshop on Update about Recovery Oriented Services (ROSeS) at 72. Gorky Medhi, Gupta AK. Endovascular coiling of partially Psychiatric Rehabilitation Services. Department of Nursing, clipped basilar top aneurysm RAIN 2014, Chennai, 14-16 NIMHANS, Bangalore, 31 January 2015 (ii) Psychosocial November 2014. Rehabilitation. Seminar in Psychiatric Nursing. Department of Nursing, NIMHANS, Bangalore, 11 March 2015 (iii) 73. Gupta A (i) Medical evaluation in neurological rehabilitation. Guidelines for volunteers & services offered at PRS. Volunteer 3rd National Conference of IFNR, Mumbai, 7-9 March Sensitization Program. Psychiatric Rehabilitation Services, 2015 (ii) Rehabilitation challenges & management strategies NIMHANS, Bangalore, 24 March 2015. in patients with TBI. 43rd National Conference of IAPMR, Trivandrum, Kerala, 29 January-1 February 2015 (iii) 66. Gautham MS (i) Descriptive statistics, Statistics in Biostatistics Neurogenic bladder & It’s management following spinal cord Simplified Workshop in Bangalore Medical College and injuries. SPINE 2014, Ahmedabad, Gujarat, 19-21 September Research Institute, Bangalore, 11 April 2014 (ii) Infectious 2014 (iv) Principles of neurological rehabilitation. Department disease epidemiology. National Level CME organized by Dept of Epidemiology, NIMHANS, Bangalore, 24 July 2014. of Community Medicine, National Institute of Unani Medicine, Bengaluru, 8 December 2014 (iii) Measures of reliability. 74. Gupta A, Nagaraj K, Taly AB, Christopher R, Prasad C. State Level Workshop on Questionnaire Development Prevalence of depression & sleep disturbance in patients with and SPSS. Organized by Dept of Community Medicine, multiple sclerosis and their correlation with fatigue. 43rd JJM Medical College, Davanagere, 20-21 January 2013 (iv) National Conference of IAPMR, Trivandrum, Kerala, 29 Risk factors for NCDs and mental health. National Mental January-1 February 2015. Health Programme–Monitoring & Evaluation. Workshop on Integrating Management of Neuropsychiatric Problems into 75. Gupta A, Sankarnarayan, Khanna M, Taly AB. Functional NCD Care for Medical officers in Kolar organized by District recovery & gait in patients with stroke: Impact of inpatient Health Department, Kolar and Department of Epidemiology rehabilitation. (i) National Stroke Conference, Chandigarh, in Kolar, 19 March 2015. 13-15 March 2015 (ii) 43rd National Conference of IAPMR, Trivandrum, Kerala, 29 January-1 February 2015. 67. Gayathri N. Mitochondrial disorders with novel mutations – a study from tertiary referral centre in South India, SMRM, 76. Gupta A, Taly AB. Functional outcome following rehabilitation Manipal, 8-9 December 2014. of patients with severe chronic TBI. 23rd National Annual Neuro-Trauma Conference, Mussoorie, Uttarakhand, 29-31 68. Girish N. A public health approach to geriatric mental health. August 2014. State Level Symposium on Mental Health Care, Chennai, 1 November 2014. 77. Gupta AK (i) Great minds meeting is a small step towards the same endeavour. Mumbai, 21 May 2014 (ii) Neuroradiological 69. Gopalakrishna KN, Umamaheshwara Rao GS, Vinay B. Fall procedures, MRI, angiogram, DSA, CT, X-Ray, US and in inspired oxygen and anaesthetic agent concentration during Doppler for in services nurses on July 15, 2014 (iii) Pediatric change of sodalime absorber. 62nd Annual National Conference neurointervention. Neurovision– 2014. 14th Annual Meeting of Indian Society of Anaesthesiologists, Madurai, 29 December of Cerebrovascular Society of India, 5-7 September 2014 2014. (iv) Recent advances in the world of endovascular procedure. 63rd Annual Conference of Neurological Society of India, 70. Gorky Medhi, Anantaram G, Jitender Saini, Chandrajit Prasad, Coimbatore, 12-15 December 2014 (v) Newer interventional Arvinda HR, Hima Pendharkar, Gupta AK. Role of flat-panel strategies for complex arteriovenous malformations. 68th detector CT in detection of peri-interventional complications. Annual Conference of Indian Radiological and Imaging 16th Annual Conference of Indian Society of Vascular Association, Kochi, 29 January- 1 February 2015 (vi) CCSVI &Interventional Radiology: Flow 2014, Mumbai, 3-6 April 2014. myth or reality. Registry meeting of ISVIR, Kolkatta, 22 November 2015 (vii) Interventions in CVT. Annual CME of 71. Gorky Medhi, Arvinda HR, Gupta AK, Hima Pendharkar, Indian Society of Neuroradiology, CMC Vellore, 7 March 2015 Chandrajit Prasad, Jitender Saini, Paritosh Pandey. Intracranial (viii) Management strategies for intracranial dural arteriovenous
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fistulae. 17th Annual Meeting of Indian Society of Vascular and 25 December 2014 (vi) Cerebral venous thrombosis: imaging. Interventional Radiology, Hyderabad, 19-22 February 2015 (ix) Annual CME of Indian society of Neuroradiology, CMC Angioarchitecture of central pial AVM and AVF at stroke and Vellore, 7 March 2015 (vii) Overview of neurointerventions advanced neurovascular intervention. SAANVI – 2015, 13-15 at NIMHANS NIMHANS–Osaka city University Joint March 2015. Scientific Program, NIMHANS, 7 January 2015 (viii) Stroke & advanced neuro vascular intervention. (a) Classification of 78. Gururaj G (i) Pattern of helmet usage and drink driving spinal vascular malformations (b) Live case discussion: bilateral in the city of Hyderabad. Road Safety Consortium flow diverter (c) Interesting case discussion: Type V dural Meeting, Hyderabad, 1-2 April 2014 (ii) Linkages between arteriovenous malformation. SAANVI 2015, Kolkata, 13-15 transportation and safety in urban India, Embarq Connect March 2015. Karo meeting, Bangalore, 8 May 2014 (iii) Strengthening occupational help through public health approaches. Founders 83. Hirisave U (i) Promotive intervention, P3 Reach Workshop, Day Celebrations of Regional Occupational Health Centre, Department of Clinical Psychology, NIMHANS, 13 August Indian Council of Medical Research, Bangalore, 24 July 2014 2014 (ii) Parenting children with behavior problems, Little (iii) Injury prevention and trauma care, National Symposium Rock Indian School, Mangalore, 16 August 2014 (iii) on Public Health Interventions: Need for Convergence, Theories relevant for child interventions, JJ Officers Workshop, Trivandrum, 28 October 2014 (iv) Road safety among young NIMHANS, 8 September 2014 (iv) Management of people: Need for data driven and evidence based policies. emotional disorders, Prasanna Counseling Centre, Bangalore, 9th National Conference on Adolescent Health, Imphal, 13 13 September 2014 (v) Child psychotherapy. Seminar at March 2015. Jayanagar National College, 17 September 2014 (vi) Panelist, Interactive session with parents on learning disability, NGO, 79. Gururaj G, Girish N. Assessment of care under district mental Reussir Trust, 17 January 2015 (vii) Psychological therapies for health care programme in Tamil Nadu, State Level Symposium children: seminar, Agnes College, Mangalore, 28-29 January on Mental Health Care, Chennai, 31 October 2014. 2015 (viii) Psychosocial care and protection for children, Kristu Jyothi College, Bangalore, 9 March 2015. 80. Hamza A, Reddy D, Parthasarthy R, Janardhan N, Suchismita M. Knowledge as adolescent sexuality among social work 84. Jadhav T, Chidananda HA, Thirthalli J, Phutane VH, Kumar trainees in India. 32nd Annual National Conference of Indian CN, Kesavan M, Gangadhar BN. Duration of increased heart Society of Professional Social Work, Coimbatore, Tamil Nadu, rate in early course of ECT predicts the clinical outcome at 28-30 January 2015. two weeks in patients with schizophrenia. IPSOCON 2014, Bangalore. 81. Hegde S (i) (a) Music and cognitive remediation: its purview in neuropsychological rehabilitation (b) Novel interventions 85. Jafar Ali. MRI artifacts, Karnataka Medical Radiographer in neurorehabilitation: music and dance therapy. 3rd Annual & Allied Technologies Association State Level Conference, Conference of Indian Federation of Rehabilitation, Mumbai, Mangalore, 8-9 February 2015. 7-9 March 2015 (ii) Neuromusicology and its contribution to neuropsychological rehabilitation. Bangalore, Research 86. James JW, Sivakumar T, Nirmala BP, Chethan B. Teaching and Interest in Neuropsychology (BRAIN) group meeting, and training students in psychiatric rehabilitation. 33rd Annual Annasawmy Mudaliar General Hospital, 1 March 2015. National Conference of Indian Society for Professional Social Work, Coimbatore 28-30 January 2015. 82. Hima Pendharkar (i) Complications in neurointervention.11th Monsoon Meet Case Presentation, Goa, 31 July-4 August 87. James JW, Nilofer B, Sivakumar T, Chethan B, Ashfaq 2014(ii) Vein of Galen malformation: embryology to A, Abishek P. Road to recovery: A case report. 5th Asia endovascular therapy. 17th Annual Conference of Indian Pacific Regional Conference on Psychosocial Rehabilitation, Society of Neuroradiology, Gurgaon, 9-12 October 2014 (iii) Bangalore, 6-8 February 2015. Carotid plaque imaging. 16th Annual Conference of Indian Society of Vascular & Interventional Radiology, Mumbai, 3-6 88. Jamsheer M. Arterial spin labelling-introduction & clinical April 2014 (iv) Spinal vascular malformations. 14th Annual application. National Conference of the Indian Society of Conference of Cerebrovascular Society of India, Bangalore, 5-7 Radiographers & Technologists, Kovalam, Trivandrum, Kerala, September 2014 (v) Spectrum of neurovascular interventions 13-14 December 2014. in pediatric patients. Indian Academy of Pediatrics, Amravati,
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89. Janardhana N, Sekar, Parthasarathy, Muralidhar. Capacity Missouri, 28-30 August 2014 (vi) Direct percutaneous building for child protection personnel on children under care treatment of a large paraspinal AVM. Neurovascon 2014, and protection of ICPS in the state of Karnataka. 32nd Annual Bangalore, 5-7 September 2014. National Conference of Indian Society of Professional Social Work, Bharathiar University, Coimbatore, 28-30 January 2015. 94. John Vijay Sagar K (i) ADHD, ASD & disruptive behavioral disorders. RBSK training programme, NIMHANS, 3 90. Janardhana N, Subrat Misha, Valliseshan, Saraswathy, Naidu. September 2014 (ii) Fogarty training experience at University of Gender perceptions of the families and communities. 32nd Florida, Indo-US Annual Fogarty Symposium,NIMHANS,13 Annual National Conference of Indian Society of Professional January 2015 (iii) Research in CAP at NIMHANS, PHFI, Social Work, Bharathiar University, Coimbatore, 28-30 January New Delhi, 28 January 2015 (iv) Child sexual abuse, JVS 2015. Lecture, PG training programme, Lonavala, 21 February 2015 (v) Prevalence of CSA and mental health issues. Drishti 91. Janardhana Reddy YC (i) OCD: clinical course and outcome. Symposium, Bangalore, 28 February 2015 (vi) Autism spectrum Workshop on CBT for OCD. Department of Clinical disorders. Psychiatry CME, SVIMS, Tirupati, 14 March 2015 Psychology, NIMHANS, 23-24 January 2015 (ii) Body focused repetitive behaviors. 30th Annual Conference of the 95. Kakumanu RJ, Nair AK, Sasidharan A, Srikumar S, Mehrotra S, Branch of the Indian Psychiatric Society (Kerala), Kochi, 26-29 John JP, Panth R, Kutty BM. Theta and lower alpha as markers September 2014 (iii)Are antidepressants safe and effective in of meditation efficiency: a study on vipassana meditators. bipolar disorder? Current Trends in the Management of Bipolar International Symposium on Translational Neuroscience and Disorders. CME, Department of Psychiatry, NIMHANS, 32nd Annual Conference of Indian Academy of Neurosciences, 23 September 2014 (iv) Atypical antipsychotics in OCD. 1st NIMHANS, Bangalore, 1-3 November 2014. (Best Paper Award) Global Conference of Biological Psychiatry, India. 10th Annual Conference of Indian Association of Biological Psychiatry, New 96. Kampanee ARM. Rehabilitation in Sakalawara community Delhi, 25-28 September 2014 (v) CBT in OCD. Therapeutic mental health center: role of clinical psychologists. Symposium Approaches in Psychiatry. CME organized by DIMHANS, on Rehabilitation at the Sakalawara Community Mental Health Dharwad and IPS (Karnataka), 21 June 2014 (vi) Depression Center using a Multidisciplinary Approach, Hyderabad, 11 in general medical practice: identification & treatment. IMA, January 2015. Raichur, 16 June 2014 (vii) Treatment guidelines for bipolar disorder: do they clarify or confuse the practitioner? College 97. Kapgal V, Hegde P, Rao LT, Kutty BM. Combination strategies of International Neuropsychopharamcology Program, Goa, 22 of environmental enrichment, physical exercise and nutritional November 2014 (viii) Lamotrigine in the treatment of bipolar supplementation enhance the spatial cognition in rats with disorder. Spandana Academic Centre, Bangalore, 1 November CNS insult. International Symposium on Translational 2014. Neuroscience and 32nd Annual Conference of Indian Academy of Neurosciences 2014, NIMHANS, Bangalore, 1-3 November 92. Jangam K, Tansa KA, Muralidharan K. Association between 2014. childhood abuse and suicide among women diagnosed with bipolar disorder and unipolar depression compared to healthy 98. Karmani SJ, Arasappa R, Muralidharan K, Thirthalli J, Yatham women. 5th Annual Conference of the Society for Bipolar LN. rTMS for bipolar depression: a review of evidence. 5th Disorders–India, SBDI 2014, Bangalore, 14 December 2014. Annual Conference of the Society for Bipolar Disorders–India, SBDI 2014, Bangalore, 14 December 2014. 93. Jitender Saini (i) Resting state f-MRI applications in epilepsy. ISNR Midterm CME on Stroke and Epilepsy 99. Kaur A. Therapist’s variables in clinical psychology Imaging. CMC, Vellore, 7 March 2015 (ii) Imaging features professionals in India. 41st National Annual Conference of of encephalitis in children. Symposium on Advanced MR Indian Association of Clinical Psychologists, PDP University, Imaging Techniques with Focus in Pediatrics. Fortis Hospital, Gandhinagar, Gujarat, 8 February 2015. Gurgaon, 27 February-1 March 2015 (iii) Imaging of brain ischemia. 21st Annual Conference of Indian Society of Critical 100. Kavitha AK, Prashant Giribhattanavar, Nagarathna S, Shripad Care Medicine. Bangalore, 4-8 March 2015 (iv) Neuroimaging A. Patil. Drug resistance pattern of mycobacterium tuberculosis after mild traumatic brain injury. Neurotrauma-2014, Missouri, isolates from cerebrospinal fluid in a tertiary neurocare centre: 28-30 August 2014 (v) Embolotherapy: clinical applications one year study. 7th Annual KSTA Conference, Bangalore, 5-6 in trauma, access, techniques and agents. Neurotrauma-2014, February 2015.
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101. Keshav Kumar J (i) Early cognitive screening assessment and Conference of the Society for Bipolar Disorders–India, SBDI cognitive interventions in elderly. World Alzheimer’s Month. 2014, Bangalore, 14 December 2014. CME on Dementia ´Dementia: can we reduce the risk? Geriatric Clinic, NIMHANS and Indian Psychiatric Society–Karnataka 109. Kulkarni KR, Purty A, Muralidharan K, Janardhan Reddy YC, Chapter Bangalore, 18 September 2014 (ii) Illustrative Indian Jain S. Sex differences in the five year course of bipolar disorder case discussion on Cross Cultural Aspects. Neuropsychological following a first episode of mania: a retrospective chart review. Rehabilitation Programme-A Multidisciplinary Clinical Skills 5th Annual Conference of the Society for Bipolar Disorders– Workshop & 28th K Gopalakrishna Endowment Oration. India, SBDI 2014, Bangalore, 14 December 2014. Chennai, 29-31 August 2014. 110. Kumar CN (i) (a) Assessments related to insanity defence. 102. Krishna Reddy N, Birudu Raju. Self care measures for social Symposium (b) Ethical and Legal issue of ECT. Symposium workers-working with terminal illness. Indian Society of on Recent Advances of ECT. ANCIPS 2015, Hyderabad (ii) Professional Social Work, Department of Social Work, Caregiver burden in chronic neuropsychiatric illnesses. CME Bharathiyar University, Coimbatore, Tamil Nadu, 28-30 on Neuropsychiatry, Sridevi Medical College, Tumkur, October January 2015. 2014.
103. Kulandaiswamy, Priya Treesa Thomas, Krishna Reddy N. A 111. Kumar CN, Phutane VH, Thirthalli J, Jayaram N, Muralidharan study on factors associated with academic discontinuation K, Mehta UM, Tyagi V, Gangadhar BN. (a) Resolution of among student with neurological disorders. 33rd Annual cognitive adverse effects of electroconvulsive therapy in persons National Conference of the Indian Society of Professional with schizophrenia: a prospective study. Indian Psychiatric Social Work, Bharathiyar University, Coimbatore, Tamil Nadu, Society-South Zone Conference, Bangalore, October 2014 (b) 28-30 January 2015. Annual National Conference of the Indian Psychiatric Society, Hyderabad, January 2015. ANCIPS-2015, Hyderabad, India 104. Kulandaiswamy, Priya Treesa Thomas, Krishna Reddy N. A (SS Jayaram Award). study on the psychosocial effects of drug resistance epilepsy. 33rd Annual National Conference of the Indian Society of 112. Kumar D. Cognition in schizophrenia: The functional Professional Social Work, Bharathiyar University, Coimbatore, significance. Annual Conference of the Indian Psychiatric Tamil Nadu, 28-30 January 2015. Society. Jharkhand State Branch, 12 October 2014.
105. Kulkarni Advaith Prakash, Kulkarni Girish Baburao, Girish 113. Kumar R, Kumar KJ. Alcoholism: an overview on subtypes and N Rao, Geetha Desai. Demographic, clinical and disability management. Symposia on Neuro Cognitive Rehabilitation. profile of migraine patients from NIMHANS a tertiary care National Conference on Cognitive and Neuropsychology: neurological university teaching hospital from Bangalore. 22nd Challenges and Issues, Christ University, Bangalore, 14-15 Annual Conference of the Indian Academy of Neurology, PGI November 2014. Chandigarh, 6-9 November 2014. 114. Lall D, Purkayastha P, Varghese J, Binukumar B, Shailendra 106. Kulkarni Girish Baburao (i) Approach to coma. 22nd Annual D, Nair S. Effectiveness of community based behavior change Conference of the Indian Academy Critical Care Medicine, strategies for lifestyle modification for primary prevention of Bangalore, 5-8 March 2015 (ii) Autonomic dysfunction in cardiovascular risk factors in adults. Sovenir, Public Health headache disorders. TS Srinivasan-NIMHANS Knowledge Evidence South Asia Colloquium, 2015, Manipal University, Conclave 2015. CME, Bangalore, 12-13 February 2015. Manipal, 5-7 February 2015.
107. Kulkarni KR, Arasappa R, Krishna Prasad M, Zutshi A, Chank 115. Laxmi T Rao (i) Stress: so diverse, yet all the same. IBRO PK, Muralidharan K, Murthy P. Persistent delusional disorder: School, Chandigarh, 7 November 2014 (ii) Role of CREB a retrospective chart review from a tertiary care centre in India. expression in prefrontal cortex and hippocampus after fear Annual Conference of the Indian Psychiatric Society–South conditioning in rats subjected to maternal separation stress. Zone, IPSOCON 2014, Bangalore, October 2014. Health Sustainability in Stressful Environment by Translational Approach/Science and Technology for Human Development. 108. Kulkarni KR, Purty A, Muralidharan K, Janardhan Reddy YC, 102nd Indian Science Congress, Mumbai, 5 January 2015. Jain S. Five year course of first episode mania: retrospective chart review from a tertiary care centre in India. 5th Annual 116. Liya John. Medical imaging in CVA. Karnataka Medical
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Radiographer & Allied Technologies Association State Level (v) Surgery for TLE. WSNS-NSI Educational Course as a Conference, Mangalore, 8-9 February 2015. Guest faculty. SGPGIMS, Lucknow, 23-25 January 2015 (vi) Epilepsy surgery. 4th Annual Conference of Neurological 117. Madhavadas S, Kapgal V, Subramanian S, Kutty BM. Spatial Surgeons Society of India, Indore, 27 February-1 March 2015 learning and memory impairment in MSG rat model of obesity. (vii) Epilepsy. Aurangabad Epilepsy Conference, Aurangabad, International Symposium on Translational Neuroscience and 28-29 March 2015. 32nd Annual Conference of Indian Academy of Neurosciences, NIMHANS, Bangalore, 1-3 November 2014. 124. Maltesh Kambali, Ravi Muddashetty, Laxmi T Rao. Impact of early life stress on remote fear memory in rats (i) International 118. Madhu N, Anish L (i) Vasculitic neuropathy in elderly: a Symposium on Translational Neuroscience and 32nd Annual clinical, electrophysiological & histopathological study from a Conference of Indian Academy of Neurosciences. Organized university hospital. 22nd Annual Conference of Indian Academy by National Institute of Mental Health and Neurosciences, of Neurology: IANCON 2014, PGIMER, Chandigarh, 6-9 Bengaluru, 1-3 November 2014 (ii) 60th Annual Conference November 2014. (Diamond Jubilee) of APPICON, 2014 organized by Association of Pharmacologists and Physiologists of India, 119. Madhu N. Tangier disease: an unusual cause of demyelinating Balia, Puri, Odissa, 20-22 November 2014 (Best Oral neuropathy. 2nd International Symposium on Peripheral Presentation Award). Nerve Disorders: NERVECON 2014, Hyderabad, 2-3 August 2014 (ii) Fatal Morvan syndrome in a patient with myasthenia 125. Manjula B, Hamza A. Impact of intervention programme on gravis. TS Srinivasan-NIMHANS Knowledge Conclave 2015 study habits of high school students. 33rd Annual National on Autonomic Dysfunction-An Interdisciplinary Workshop Conference of the Indian Society of Professional Social Work, for Clinicians and Scientists, NIMHANS, Bangalore, 12-13 Bharathiyar University, Coimbatore, Tamil Nadu, 28-30 February 2015. January 2015.
120. Madhusudana SN (i) Immunopathogenesis of rabies; Studies in 126. Manjula M (i) Coping with work stress. Workshop for Support mice and its implications in human rabies. IMMUNOCON Group Working on Mental Wellness, Workplace of Hindustan 2014, Madurai, December 2014 (ii) Recent Advances in rabies. Unilever Employees. Training of the trainers. Sigma Tech Park, 4th Annual Conference of the Clinical Infectious Diseases Bangalore, 15 April 2014 (ii) Handling romantic relationships. Society, Bangalore, 22-24 August 2014. Workshop on Maintaining Healthy Relationships for Youth. NCWB, Bangalore, 26 April 2014, 6 December 2014 (iii) 121. Madhusudana SN, Reeta Mani, Satishchandra P, Netravathi Orientation to UG students from Maldives. NIMHANS, M, Veeranna MG, D’Souza A, Udani V, Ashwin YB, Ashwini Bangalore, 12 June 2014 (iv) Emotions and its regulation. MA. Human rabies survivors: From scientific curiosity to Workshop on Emotion Regulation for Healthy Living. scientific reality. 16th National Conference of the Association NCWB, Bangalore 21 June 2014 (v) Understanding each for Prevention and Control of Rabies in India, Mysore, 5-6 July other–difficulties faced by parents and teenagers. Maintaining 2014. Healthy Parent Teenager/Young adult Relationships: A Workshop for parents and youth. NCWB, Bangalore, 5 July 122. Malik K. Training and supervision variables among clinical 2014 (vi) Sessions on History taking in sexual dysfunctions; psychology professionals in India. 41st National Annual approaches to sex therapy–other methods of therapy. Workshop Conference of the Indian Association of Clinical Psychologists, on Cognitive Behaviour Therapy in Sexual Dysfunctions. Ahmedabad, 6-8 February 2015. NIMHANS, Bangalore 25-26 July 2014 (vii) Facing Exams Effectively. Workshop on Managing Academic Stress. NCWB, 123. Malla Bhaskara Rao. (i) Evaluation of humans’ brain and neuro Bangalore, 29 September 2014 (viii) Behaviour therapy sciences, Sci-Navigate 2014 Innovation in Science Pursuit unit– orientation to visitors from Bangladesh. Department for Inspired Research. Christ University, Bangalore, 24 April of Clinical Psychology, NIMHANS, Bangalore, 4 October 2014 (ii) Case of occipital lobe FCD, Epilepsy Conclave 2014, 2014 (ix) (a) Managing emotions (b) Relationship issues Goa, 12-13 July 2014 (iii) Medial temporal AVM presenting and intergenerational connect. Training Session for Yuva with drug resistant epilepsy. Neurovascon 2014 Conference. Parivarthakas, Department of Epidemiology, NIMHANS, NIMHANS, Bangalore, 5-7 September 2014 (iv) National Bangalore, 28-29 October 2014 (x)Sessions on Cognitive epilepsy surgery support activity. 63rd Annual Conference of behavioural assessment; behavioural strategies in cognitive NSI (NSICON2014). Coimbatore, 12-15 December 2014 behaviour therapy; cognitive behavioural model of depression.
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Workshop on Cognitive Behaviour Therapy: Principles and 131. Medhi G, Arvinda HR, Gupta AK, Pendharkar H, Saini J, Applications. NIMHANS, Bangalore, 30-31 October 2014 (xi) Prasad C, Netravathi M. Transverse sinus stenting for idiopathic Emotion regulation therapy. Workshop on Mindfulness-Based intracranial hypertension: a review of 13 Patients. 16th Annual Cognitive Behavioural Interventions: Applications in Clinical Conference of Indian Society of Vascular & Interventioinal and Non-Clinical Settings. NIMHANS, Bangalore, 21-22 Radiology flow 2014, Mumbai, 3-6 April 2014. November 2014 (xii) (a) Managing emotions (b) Relationship issues and intergenerational connect. Training Session for Yuva 132. Medhi G, Saini J, Sinha S, Bagepally BS, Thennarasu K, Prasad Parivarthakas, Department of Epidemiology, NIMHANS, C. White matter alterations in juvenile myoclonic epilepsy: a Bangalore, 6-9 December 2014 (xiii) Emotions: functions, diffusion tensor imaging study. Philips Neuro MR Challenge motives, values and building awareness. Workshop on Know 2014, 6 April 2014. Your Feelings and Handle them Better. Lingaraj College, Belgaum, 29 January 2015 (xiv) Cognitive behavioral assessment 133. Meera SS, Ravi GS, Shivashankar N. Pragmatics of language in OCD: Assessing symptoms, beliefs, family accommodation. in the broad autism phenotype. 47th ISHACON, Manipal, 1-3 Workshop on Cognitive Behaviour Therapy for Obsessive January 2015. Compulsive Disorder. NIMHANS, Bangalore, 23-24 January 2015 (xiv) Orientation to Institute and Department of Clinical 134. Mehrotra S. Supporting wellbeing and strengthening resilience Psychology for visitors from Belaguam–PG and UG students. at workplace: strategies and applications. Supporting Mental Department of Clinical Psychology, NIMHANS, Bangalore, Wellness of Employees Workshop, Hindustan Unilever, 13 February 2015 (xv) (a) Managing emotions (b) Relationships Bangalore, 15-16 April 2014. and intergenerational connect. Training Session for Yuva Parivarthakas, Department of Epidemiology, NIMHANS, 135. Mehta U (i) Neurobiology of positive psychiatry. Dr. NS Vahia Bangalore, 24-25 March 2015 (xvi) Sessions on stress and Foundation Weekend Course on Positive Psychiatry, Mumbai, stress management; essentials of interpersonal relationships and 28 February 2015. counseling in relationship issues. Train the Trainer-Life Skills Workshop for Lecturers. Mount Carmel College, Bangalore, 30 136. Mehta UM, Abhishek HA. Early motor resonance differentiates March 2015. schizophrenia patients from healthy subjects and predicts social cognition performance. Annual National Conference of the 127. Manjula M, Roopesh BN, Philip M. Depression, suicidal risk Indian Psychiatric Society, ANCIPS, Hyderabad, 9 January and self harm attempts in school and college going adolescents: 2015. (Bhagwat Award). an Indian study. 41st National Annual Conference of the Indian Association of Clinical Psychologist, Institute of Research 137. Michael RJ. Youth mental health and wellbeing promotion: and Development, Raksha Shakthi University, Gandhinagar, initiatives. National Seminar on Youth Civic Engagement in Gujarat, 6-8 February 2015 (Best Paper Award). India: Interdisciplinary Perspectives. Department of Human Development and Family Studies, M. S. University of Baroda, 128. Manjunath. A comparative study of mPCR, MLPA and muscle Vadodara, 17-18 September 2014. biopsy results in a cohort of children with Duchenne Muscular Dystrophy: A first study, 22nd IANCON 2014, PGIMER, 138. Muralidharan K (i) What a clinician should know about ECT? Chandigarh, 6-9 November 2014 (Platform in Award 35th Annual Conference of General Practitioners, Hubli, 20 Category). April 2014 (ii) Co-morbidities in bipolar disorder: treatment challenges. CME, Bangalore, 24 June 2014 (iii) Metabolic 129. Manoj JM, Ghosh D, Venkatesh HN, Narasinga Rao KVL, syndrome in bipolar disorder. CME on Current Trends in the Bhat DI, Chetan GK. (i) (a) Association between CpG island Management of Bipolar Disorders organized under the BRAIN promoter methylation f MGMT and TP53 genes in different initiative, NIMHANS, Bangalore, 23 September 2014 (iv) types of high grade glioma (ii)Association between CpG island Treatment of schizophrenia with mood symptoms. INSTAR promoter methylation of MGMT and TP53 genes in different Workshop for Postgraduates, Bangalore, 6 December 2014 types of high grade glioma, ISNOCON, Kochi, 27-29 March (v) Treatment adherence in bipolar disorder: challenges. 5th 2015. Annual Conference of the Society for Bipolar Disorders–India, SBDI 2014, Bangalore, 14 December, 2014 (vi) Neurocognitive 130. Maya Bhat. Inborn errors of metabolism-imaging approach deficits in early bipolar disorder. World Bipolar Day, Hyderabad, & diagnostic clue. CME by IMSA Karnataka Chapter, 7 March 2015. November 2014.
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139. Mutharaju A, Dhanasekarapandian R. Awareness programme imaging histopathological and electron microscopic studies, on myths and misconceptions about alcohol and tobacco use IANCON 2014, Chandigarh,6-8 November 2014. (v) Case among PUC students. 33rd Annual National Conference of discussion on Muscle disorders,, SHINE, Chennai, 8 March the Indian Society of Professional Social Work, Bharathiyar 2015 (Best Poster Award). University, Coimbatore, Tamil Nadu, 28-30 January 2015. 147. Nambiar S, Manjula M. Integrating mindfulness with CBT in 140. Nagappa M, Bindu PS, Sonam K, Govindaraju C, Mahadevan a client with GAD, depression and cluster C personality traits. A, Yasha TC, Gayathri N, Sinha S, Taly AB. Neuropathy in 41st National Annual Conference of the Indian Association inherited metabolic disorders: clinical, electrophysiological of Clinical Psychologists, Ahmedabad, Gujarat, 6-8 February and histopathological profile of 80 patients from a university 2015 (Best Paper Award). hospital, NERVECON 2014, Hyderabad, 2-3 August 2014 (Best Paper Award). 148. Nandakumar DN, Hurmath FK, Palaniswamy R. Neurotransmitter and immune-mediated mechanisms in 141. Nagappa M, Sonam K, Govindaraj C, Khan NA, Govindaraj growth and spread of brain tumour. 2nd Annual Conference P, Shwetha C, Bindu PS, Taly AB, Gayathri N, Mahadevan A, AMBKC, Sri Devaraj Urs Medical College, Kolar, 10-12 Yasha TC, Sinha S, Thangaraj K. Mitochondrial neuropathies: September 2014. phenotypic spectrum & genetic correlates in 35 patients from a large cohort at NIMHANS, India. International Symposium on 149. Nandakumar DN, Hurmath FK, Palaniswamy R. Tumour- Translational Neuroscience & 32nd Annual Conference of the promoting inflammation and tumour microenvironment Indian Academy of Neurosciences, Bangalore, 1-3 November in glioblastoma. 28th Annual Meeting of Society for 2014. Neurochemistry, India (SNCI) and National Conference on Neurodegenerative Disorders and Metabolic Diseases, Sri 142. Nagarathna S. Advanced trends in clinical microbiology. Ramachandra University, Chennai, 10-12 September 2014. National Conference of AMI, Mysore chapter, Mysore, 3 April 2014. 150. Nandakumar DN, Palaniswamy R, Hurmath FK. Growth and progression of glioblastoma mediated through activation 143. Nagesh Kumar S, Gupta A, Taly AB. Urodynamic profile of of AMPA and NMDA receptors of glutamate. 7th Annual patients with Parkinson’s disease & multiple system atrophy: a Conference of the Indian Society of Neuro-Oncology, Kochi, pilot study. National Mid-Term CME, IAPMR, Bhopal, MP, 26-29 March 2015. 19-21 September 2014 (Second Prize). 151. Nandakumar DN. Bone and brain: glutamate receptors and 144. Nahar A, Kishore C, Desai G, Thippeswamy H, Chandra PS. its signaling in bone. DNB Postgraduate Programme. Sanjay A three year naturalistic follow-up study of bipolar disorder Gandhi Institute of Trauma and Orthopaedics. Bangalore, 22 during postpartum period. 5th Annual Conference of the April 2014. Society for Bipolar Disorders- India, NIMHANS, Bangalore, 14 December 2014. 152. Nandeesh BN (i) (a) Approach to squash smear interpretation (b) Pathology of meningeal based neoplasms. CME in 145. Nair AK, Sasidharan A, John PJ, Mehrotra S, Kutty BM. Neuropathology, MS Ramaiah Medical College, Bangalore, Quick and easy meditation: Rapid state changes in Rajayoga 14 March 2015 (ii) Pathophysiology of Hirschprung’s disease. practitioners. International Symposium on Translational 5th National Hands – on Workshop on the Diagnosis of Neuroscience and 32nd Annual Conference of Indian Academy Hirschsprung’s Disease (HD) and Allied Disorders. St. John’s of Neurosciences, NIMHANS, Bangalore, 1-3 November 2014 Medical College, Bangalore, 20-21 February 2015. (Best Paper Award). 153. Natal P (i) Dealing with faulty cognitions among individuals 146. Nalini A (i) Immune mediated neuro muscular disorders, with alcohol dependence. One Month Training Program on Prof. Balaparmeshwar Rao Symposium, Tirupati, 22 June Substance Abuse Management for Medical and Non-medical 2014 (ii) Peripheral nerve disorder. International Symposium, Professionals, Center for Addiction Medicine, NIMHANS, 13 Hyderabad, 3 August 2014 (iii) Diagnosis in muscular November 2014 (ii) Relapse prevention in alcohol dependence: dystrophy, genetics v/s histopathology, 10th Edition of NeuCon a family-based approach. One-month Training Program on 2014, Controversies in Neurology, Hyderabad, 17 August 2014 Substance Abuse Management for Medical and Nonmedical (iv) MYH2, MYH3, MYH7 and MYH8 types by clinical, MR Professionals, Center for Addiction Medicine, NIMHANS,
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20 November 2014 (iii) Advanced in-Country Research Grant Bangalore, 13 February 2015 (iii) Expressed emotions. Work Non-medical use of Prescription Medicines in Bangalore, Behavior and Self Esteem in Patients with Severe Mental NIMHANS Research Grant on Development and evaluation Illness Attending Psychiatric Rehabilitation Facility Bharthiyar of the effectiveness of integrated audio visual aided interactive University Coimbatore, Tamil Nadu, 28-30 January 2015. relapse prevention intervention among individuals with alcohol dependence. Central and State Government Mental 160. Nisha C, Jamuna R, Divya S. Organic mood disorder tweeking Health Settings, Current Research Update, Fogarty Annual the brain with EEG neurofeedback, neuropsychological Symposium & Chaos Assessment Workshop, 14 January rehabilitation programme. A Multidisciplinary Clinical Skills 2015 (iv) Inputs for treatment Development Workshop (Focus workshop & The 28th K Gopalakrishna Endowment oration, Group Discussion) on Home-based detoxification and relapse Chennai, 29-31 August 2014. prevention, Centre for Addiction Medicine, NIMHANS, Bengaluru, 30 March 2015. 161. Nitin M, Ramesh VJ, Radhakrishnan M. Cardiac output and other hemodynamic changes with prone position in cervical 154. Nattala P, Krishnasamy L, Ramakrishna, Gandhi S. Addressing myelopathy patients undergoing surgery-A pilot study. 16th the challenge of relapse prevention in tobacco National Conference of Neuroanaesthesia and Critical Care, dependence: role of nursing professionals. Workshop on SGPGI, Lucknow, UP, 29-31 January 2015. intervening with Tobacco Users: Role of Nursing Professionals, NIMHANS, 8 October 2014. 162. Nitin, Sriganesh. Comparison between suction above cuff endotracheal tube (SACETT) and standard endotracheal tube 155. Nayana Murali. Magnetic resonance spectroscopy. National (SETT) on the incidence of ventilator associated pneumonia Conference of the Indian Society of Radiographers & in Neuro ICU. 16th Annual Conference of Indian Society of Technologists, Kovalam, Trivandrum, Kerala, 13-14 December Neuroanaesthesiology and Critical Care, Lucknow, 30 January- 2014. 1 February 2015.
156. Nesin Mathew, Sabitha K Nair, Anupam Gupta, Laxmi T 163. Nityananda, Birudu Raju, Reddy NK. Emerging trends in social Rao. (i) Behavioural validation of motor functions in rats work education in India. 33rd Annual National Conference of subjected to constraint induced movement therapy in ischemic the Indian Society of Professional Social Work, Bharathiyar stroke model. 32nd Annual Conference of Indian Academy of University, Coimbatore, Tamil Nadu, 28-30 January 2015. Neurosciences, Bangalore 1-3 November 2014 (ii) Effect of constraint induced movement therapy in motor recovery in rat 164. Nupur Pruthi (i) Training in microvascular anastomoses using model of ischemic stroke. Indo-French Seminar on Women in rat femoral vessels: Comparison of immediate and delayed Science, IISc, Bangalore, 3-5 February 2015. patency (a) 14th Annual Conference of Cerebrovascular Society of India, 5-7 September 2014 (b) 21st Annual Conference of 157. Netravathi M (i) (a) Wilson’s disease therapy (b) Autoimmune Uttar Pradesh and Uttarakhand: NEUROCON UP and UK, encephalitis–etiology and pathogenesis (c) Profile of 14 February 2015. autoimmune encephalitis IANCON 2014, Chandigarh, 16-18 November 2014 (Best Poster Award). 165. Padmanabhan B. Structural biology of the epigenetic marker, BRD2. National Symposium on Biophysics and Golden Jubilee 158. Netravathi M, Kamble N, Pal PK, Satishchandra P. Spectrum Meeting of Indian Biophysical Society, Jamia Milia Islamia, of clinical and radiological features in 10 patients with New Delhi, 14-17 February 2015. autoimmune synaptic encephalitis. 22nd Indian Academy of Neurology Conference, Chandigarh, 6-9 October 2014. 166. Palaniswamy R, Hurmath F, Nandakumar DN. Pro- inflammatory environment in glioma growth and progression. 159. Nirmala BP. Bridge employment to independent living 28th Annual Meeting of Society for Neurochemistry, India of persons with intellectual disability invited by NIMH (SNCI), Sri Ramachandra University, Chennai, 10-12 Secunderabad for National consultative committee to chalk September 2014. out action plan to develop an outline modular programme for persons with mental illness/caretakers, personnel/professional. 167. Palash Mandal, Vigneshwaran K, Sekar K, Aravind Raj E. 7 July 2014 (ii) Recent emerging avenues challenges and Psychological impact of Pune landslide disaster on survivors. holistic approaches towards psycho social rehabilitation Regional Conference on Science and Technology for Disaster practices, REACH Conference 2015. St.Anne’s College ulsoor, Management Jointly organized by Karnataka Science
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and Technology Academy and School of Earth Science, Modulation of heart rate variability in response to physiotherapy Central University of Karnataka, Gulbarga, Dr. S.M. Pandit and add on yoga intervention in patients with Duchenne Rangamandir, Kalaburagi, 22-23 January 2015. muscular dystrophy, AANEM 61st Annual Meeting, Georgia, 29 October -1 November 2014. 168. Pathak A. (i) (a) Prevention of divorce in women with married illness. (b) Early onset schizophrenia: New insights, ANCIPS, 174. Prabha S. Chandra (i) Sexual issues in palliative care. 2015, Hyderabad. International Association of Palliative Care Conference, Hyderabad, 15 February 2015 (ii) Psychosocial needs in 169. Pathak A, Ahammed A, Chethan B, Sujai R, James JW, Reddy the antenatal period. Joint Program with Bangalore Birth RP, Vijayan TV, Sivakumar T, Kumar CN, Gandhi S, Nirmala Network, NIMHANS Centre for Well being, Bangalore, BP, Bhola P, Kumar D, Desai G, Thirthalli J, Chaturvedi 5 November 2014 (iii) Moderator for the Panel Discussion SK. (i) Socio-demographic profile, psychosocial correlates of on Psychopharmacology in Bipolar Disorders. 5th Annual inpatient referrals to psychiatric rehabilitation services and Conference of the Society for Bipolar Disorders, India, 14 service utilization at a tertiary neuro psychiatric institute in December 2014 (iv) Moderator for the Panel discussion on- India.(ii) Awareness and utilization of disability benefits What is Spiritual care in the Indian context? Colloquium on among persons attending daycare at psychiatric rehabilitation Spirituality in Palliative Care, Bangalore, 11-12 February 2015. services, NIMHANS, Bengaluru. (Best Poster Award) (iii) Utility of outpatient services at psychiatric rehabilitation 175. Prabhakar P, Christopher R, Chandra SR. Circulating services, NIMHANS, Bangalore (iv) Quality of life, enjoyment microRNAs could be a molecular bio-marker for small vessel and satisfaction among clients attending day care at psychiatric disease identification. 7th Annual Karnataka Science and rehabilitation services, NIMHANS, Bangalore: a pilot Technology Conference 2015, Bangalore, 5-6 February 2015 study. 5th Asia Pacific Regional Conference on Psychosocial (Second Prize). Rehabilitation, Bengaluru, 6-8 February 2015. 176. Prabhuraj AR. (i) (a) Can radiological images predict poor 170. Pawanraj PI, Kulkarni Girish Baburao, Pooja M, Chakradhar surgical outcome in dorsal ossified longitudinal ligament? N, Kulkarni Advaith Prakash, Mustare Veerendrakumar. (Best Poster Award) (b) Intracranial cryptococcoma–10 year’s Episodic neurological dysfunction in hereditary peripheral Institutional experience. NSICON 2014, Coimbatore, 12- neuropathy–a rare cause for a common presentation. 22nd 15 December (ii) Hydrocephalus associated with vestibular Annual Conference of the Indian Academy of Neurology, PGI schwannoma: management options and factors predicting Chandigarh, 6-9 November 2014. CSF diversion after primary surgery. Skull Base Conference, JIPMER, Pondicherry, 9-12 October 2014. 171. Phalguni Anand Alladi. Does aging affect the glia? Insights from the human substantia nigra pars compacta. Development, 177. Pradeep BS. Accident and emergency services and hospital degeneration and regeneration of neurons: neurochemistry disaster management for the medical officers training. State to clinical neurology. NEUROCON 2015, Department Institute of Health and Family Welfare, Karnataka, 22 April of Biochemistry, IPGMER, Division of Cell Biology and 2014 (ii) Youth health behaviors and concerns: results of a study Physiology, CSIR-Indian institute of Chemical Biology, from Himachal Pradesh. Symposium on Youth Mental Health Haldia, West Bengal, 7-10 January 2015. in India: A Public Health Perspective. NIMHANS, Bangalore, 3 December 2014 (iii) Questionnaire development. State Level 172. Pooja Shree Mishra, Dinesh K Dhull, Anu Mary Varghese, Workshop on SPSS and Questionnaire Designing and Coding, Vijayalakshmi K, Sathyaprabha TN, Nalini A, Phalguni Anand JJM Medical College, Davanagere, 21-22 January 2015. Alladi, Raju TR. Astroglial and microglial responses in an experimental model of sporadic amyotrophic lateral sclerosis. 178. Pradeep VR, Pradeep. Y. (i) (a) A comparative study on the 32nd Annual Conference of Indian Academy of Neuroscience, difference between NRT and behavioral mapping in cochlear NIMHANS, Bengaluru, 1-3 November 2014. implant- A case study. (b) Variation in impedance measurement in cochlear implant children 12th Annual CIGICON, Delhi, 173. Prabha Chandra, Geetha Desai, Supraja TA, Veena A December 2014. Satyanarayana, Kavita V Jangam, Thennarasu K, Seena Thomas K, Latha Venkatram, Aruna Muralidhar. Are somatic 179. Pradeep Y (i) Auditory neuropathy–a spectrum disorder. Annual symptoms in pregnancy an idiom of psychological distress? Conference of Tamil Nadu chapter–ISHA (TANISHA), Prospective assessment of maternal mental health study. Yercadu, September 2014 (ii) Electrophysiology in hearing.
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Father Muller’s College of Speech and Hearing, Mangalore, Indian Society of Professional Social Work, Bharathiyar March 2015. University, Coimbatore, Tamil Nadu, 28-30 January 2015.
180. Prakash LM. Fusion of imaging and therapy with recent 183. Nattala Prasanthi,, Pratima Murthy, Jayashree Ramakrishna, advances in technology. External Devices for Reducing Scattered Kit Sang Leung, Sreevani Rentala. Effectiveness of video- Radiation Tata Memorial Centre, Mumbai, 6-7 December enabled interactive relapse prevention intervention in alcohol 2014 (ii) Indian Society of Radiographers and Technologists, dependence at central and state government mental health NCISRT-2014, Thiruvananthapuram, Kerala, 13-14 December settings. 67th Annual National Conference of the Indian 2014 (iii) Qualitative comparison of 1.5t to 3t neuroimaging. Psychiatric Society, 11 January 2015. 12th State Level Annual Conference and 19th Scientific Meet. JJM Medical College, Bapuji Hospital, Davangere, 11 184. Nattala Prasanthi, Murthy Pratima, Ramakrishna Jayashree, May 2014 (iv) DTI imaging of spine and the secret behind a Leung KS, Rentala S. Navajeevana: Video-enabled interactive good chest radiography. 13th State Level Annual Conference, relapse prevention intervention in alcohol dependence. Films Fr Muller Medical College, Mangalore1,7-8 February 2015 for Health, organized by Department of Mental Health. (v) Imaging spectrum of intracranial hemangiopericytoma. Education, NIMHANS, 15 November 2014. Medical Imaging Technology School of Allied Health Sciences Manipal University, Manipal, 14-15 March 2015. 185. Prashant D, Manjula R, Padmanabhan B. (i) Screening of potential inhibitors of Keap1-Nrf2 interaction (ii) Identification 181. Pramod Kumar Pal (i) Video session: movement disorders: of novel inhibitors for human SIRT1 by in-silico screening. Phenomenology and differential diagnosis. 3rd IAN 43rd National Seminar on Crystallography, CDRI, Lucknow, Postgraduate Summer Course in Neurology, NIMHANS, 12-14 November 2014 (Best Poster Award). Bangalore, 10-13 April 2014 (ii) Clinical approach to a patient with dystonia. 2nd Movement Disorders Update, Kolkata, 186. Prashant Giribhattavanar, Madhusudan Patil, Kavitha Kumar, West Bengal, 26-27 July 2014 (iii) Video sessions in movement Shripad A Patil. Immunoconfirmation of central nervous disorders, SHINE 2015, Chennai, 6 March 2015 (iv) Debate- system tuberculosis by blotting–a study of 100 cases. 7th When to perform DBS in PD? Early or later. Controversies Annual KSTA Conference, Bangalore, 5-6 February 2015. in Neurology, Hyderabad, 16-17 August, 2014 (v) Psychogenic movement disorders: A clinical profile of 73 patients. 22nd 187. Prateeksha V, Annleethu Thomas, Akshaya Mathew, Meera SS, Indian Academy of Neurology Conference, Chandigarh, 6-9 Yamini BK. Dysphagia assessment using modified repetitive October 2014 (vi) S. Janaki Memorial Oration Understanding saliva swallow test (MRSST) in patients with Amyotrophic the pathophysiology of Spinocerebellar ataxias through genetics, lateral sclerosis (ALS). 47th Indian Speech and Hearing neurophysiology, structural and functional neuroimaging. 54th Conference, Manipal, 1-3 January 2015. Annual Conference of the National Academy of Medical Sciences, Rishikesh, 19 October 2014 (vii) (a) Management for 188. Pratima Murthy (i) Substance use disorders. World advanced Parkinson’s disease (b) Approach to dystonia. CME Deaddiction Day, Rajarajeswari Medical College & Hospital, Neurovision Odisha, Bhubaneswar, Odisha, 1 November 2014 26 June 2014 Key note address (ii) Tobacco cessation. United (viii) Psychiatric and cognitive problems in Parkinson’s disease. Diabetes Forum event, Challenges in Diabetes 2014, Mumbai, National Conference on Cognitive and Neuropsychology: 19-20 April 2014 (iii) Tobacco cessation at individual level. Challenges & Issues, Christ University, Bangalore, 14 CME on Tobacco Control-Where are we? And What to Do? November 2014 (ix) Autonomic dysfunction in Parkinson’s JSS Hospital, Mysore, 11 May 2014 (iv) Tobacco cessation. disease. TS. Srinivasan Knowledge Conclave 2015: Workshop World No Tobacco Day. Organised by the State Anti-Tobacco on Autonomic Dysfunction, NIMHANS, Bangalore, 12-13 Cell, Directorate of Health & Family Welfare, Karnataka, 31 February 2015 (x) Psychogenic movement disorders. First May 2014 (v) General approaches to nicotine deaddiction and CME in Movement Disorders conducted by the Movement Pharmacotherapy of nicotine deaddiction. CME on Nicotine Disorders Society of India, AIIMS, New Delhi, 3-4 January Deaddiction: Towards Freedom from Tobacco, KMC Manipal, 2015. 7 June 2014.
182. Prasad K, Ram D, Bhattacharjee D, Sadananda Reddy, Hamza 189. Preethi AN, Jamuna R, Taly AB, Divya S. Igniting the A. Dyadic adjustment and marital communication of persons brain: neuropsychological rehabilitation in gas geyser with depression. 33rd Annual National Conference of the syndrome neuropsychological rehabilitation programme-A
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Multidisciplinary Clinical Skills Workshop & 28th August 2014 (ii) The cognitive perspectives of dementia. KMC Gopalakrishna Endowment Oration, Chennai, 29-31 August Hospital, Manipal University, Manipal, 22 September 2014 2014. (iii) EEG neurofeedback- principles and application. National Conference on Cognition and Neuropsychology: Challenges 190. Preethish-Kumar V, Nalini A, Saini J Polavarapu K. Monomelic and Issues, Christ University, Bangalore, 14-15 November 2014 amyotrophy (Hirayama disease) and bi-brachial amyotrophy: (iv) Holistic neuropsychological rehabilitation. 3rd Annual phenotypically distinct but identical by MR imaging. Indian Conference of Indian Federation of Neurorehabilitation, Academy of Neurology Conference, Chandigarh, 6-9 Mumbai, 6-9 March 2015 (v) Child psychology cognitive November 2014. aspects with special reference to children in conflict with law. Tamil Nadu State Judicial Academy, Chennai, Sunday, 22 191. Preethish-Kumar V, Nalini A, Sathyaprabha TN, Kedar Mal, March 2015. Raju TR , Chandrajit Prasad. Quantitative sudomotor axon reflex testing detects normal postganglionic sympathetic 199. Raju TR (i) Control of posture and movement: motor neuron functioning in anterior horn cell disorders. TS Srinivasan- degeneration at the APPI Bangalore Chapter, NIMHANS, NIMHANS Knowledge Conclave. NIMHANS, 12-13 Bangalore,19 April 2014 (ii) Understanding brain functions: February 2015. first step towards to brain control interface (a) National Conference on Cognitive and Neuropsychology: Challenges and 192. Prem N, Kumar V, Rao LT, Kutty BM. Assessment of sustained Issues, organized by the Dept. of Psychology, Christ University, attention in 5-choice serial reaction time task (5-CSRTT) in Bangalore, 14-15 November 2014(b) Second Lab Research male Wistar rats. International Symposium on Translational Council on Brain Control Interface to explore the possible Neuroscience and 32nd Annual Conference of Indian Academy military applications in future by DEBEL, DEBEL, 30 May of Neurosciences NIMHANS, Bangalore, 1-3 November 2014. 2014 (iii) Translational research in neurophysiology- need of the hour. 8th Annual Conference of Association of Physiologist 193. Prem N, Rao LT, Kutty BM. Characterization of sleep-wake of Tamil Nadu organized by Department of Physiology, behavior in a rat model of Schizophrenia. 8th Congress of Madha medical College & Research Institute, Chennai, 11- Asian Sleep Research Society-2014, Thiruvananthapuram, 12 October 2014 (iv) Glial plasticity and neurodegeneration. Kerala, 22-24 September 2014. 60th Annual Conference of Association of Physiologists & Pharmacologists of India, Puri, 20-22 November 2014 (v) Is 194. Radhakrishnan M, Pirjo Mannenien, Harihar Dash, amyotrophic lateral sclerosis an augmented neuroinflammatory Dilip Kulkarni. Teaching and training programmes in disease? 21st Annual Symposia of Ranbaxy Science Foundation neuroanaesthesia: Panel discussion, Indian Society of conducted at the International Centre for Genetic Engineering Neuroanaesthesia and Critical Care 2015, Lucknow, 31 & Biotechnology, New Delhi, 9 March 2015. January-01 February 2015. 200. Ramesh VJ, Sritam S Jena, Dhaval Shukla, Rita Christopher. 195. Radhakrishnan M. Mechanical ventilation in neuro patients. Outcome of hypernatremia in neurological/neurosurgical AIIMS Neuroanaesthesia Update 2014, New Delhi, 30- patients: a retrospective analysis. 16th Annual Conference 31 August 2014 (ii) Anesthesia for deep brain stimulation. of Indian Society of Neuroanaesthesiology and Critical Care, ISACON 2014, Madurai, 26-29 December 2014. Lucknow, 31 January 2015-2 February 2015.
196. Ragasudha Botta. Complications of cranioplasty: an 201. Ramesh VJ (i) Positions in Neurosurgery and its anaesthetic observational study of 112 cases in a tertiary neurocare centre. implications, CME- Neuroanaesthesia and Neurotrauma, NSICON 2014. Coimbatore, 12-15 December 2014. Bangalore, 31 August 2014 (ii) Neuromuscular problems in the intensive care, Neurocritical care workshop in CRITICARE 197. Raghu, Aravind Raj E. Work life balance and mental health 2015, Bangalore, 5 March 2015. among management personnel’. National Conference on Inclusive and Sustainable Growth for Emerging Economies 202. Ravi GS (i) Statistical methods using R. Pre-Conference like India. T. John’s Institute of Management and Science, Workshop. 30th Annual Conference of Indian Psychiatric Bangalore, 9 December 2014. Society, Kaloor, Kochi, 26-28 September 2014.
198. Rajeswaran J (i) EEG neurofeeback training. National 203. Ravi GS, Thennarasu K, Vani Santosh. Aquantile regression Neurotrauma Society of India, Missouri, Uttarakhand, 29-31 approach for non-normal and heteroskedastic data-a simulation
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study ISMS 2014, University of Jammu, Jammu, 1-3 November 212. Reeta Mani, Ashwini MA, Madhusudana SN. Myriad 2014 manifestations of rabies: role of laboratory and medical, social . and legal implications. Annual Conference of the Indian 204. Ravi V (i) Bioinformatics in virology. DST Sponsored National Association of Medical Microbiologists, Jaipur, 15-19 October Workshop on Bioinformatics and its Application to Neural 2015. Disorders NIMHANS, Bengaluru, 5-8 August 2014 (ii) Acute encephalitis syndrome: a microbiologist’s perspective. 213. Rohini M Surve, Radhakrishnan M, Umamaheswara Rao 38th Annual Conference of Indian Association of Medical GS. The effect of blood transfusion on central venous oxygen Microbiologists. SMS Medical College, Jaipur, 15-19 October saturation (SCVO2) in patients admitted to a Neurointensive 2014 (iii) Lab QMS implementation in NACP/ RNTCP/ care unit. 21st Annual Conference of Indian Society of Critical Vectorborne Diseases Program–commonalities and learning Care Medicine, Bengaluru, 4-8 March 2015. from promising practices. NACO-PCI Meet, New Delhi, 3-4 December 2014. 214. Roopesh BN, Prateeksha S, Lalmingmawii, John KV. Cognitive inhibition deficits in children with conduct disorder. 205. Ravi V, Ananthakrishna NC. Virology-paradox of our time. National Annual Conference of Indian Association of Clinical CME on Virology, Kasturba Medical College, Mangalore, 28 Psychologists, Ahmedabad, 6-8 February 2015. March 2015. 215. Roopesh BN, Saswatika T, Sharma M, Benegal V. Decision 206. Ravi Yadav (i) Is palmomental reflex an important marker making in patients with alcohol dependent syndrome. A of REM sleep behavior disorder in patients with Parkinson’s preliminary report. National Annual Conference of the Indian disease?. Asian Society of Sleep Research Congress, Association of Clinical Psychologists. Chennai, 28 February-2 Trivandrum, Kerala, 22-24 September 2014 (ii) Balance and March 2014. radiological characterization of different clinical subtypes of progressive supranuclear palsy. NSICON 2014, Coimbatore, 216. Roopesh BN (i) Specific learning disability. Panel discussant for Tamilnadu, 12-14 December 2014. the Interactive program organized by Reussir Trust and Times Group, Bengaluru, 17 January 2015 (ii) Disruptive behavior 207. Ravikumar R. Pre-analytical microbiology – an emerging area for disorder. Workshop on Behavioral Disorder organized by automation for standardization and productivity enhancement. Department of Nursing, NIMHANS, Bengaluru, 22 January MICROCON 2014, Jaipur, 15-19 October 2014. 2015.
208. Ravish HS, Madhusudana SN, Ashwathnarayana DH et 217. Rose Dawn Bharath (i) Imaging of spine. IAN Summer al. Interchangeability of modern cell culture rabies vaccines. Course. NIMHANS, 11 April 2014 (ii) Imaging in PRES. Immunogenicity and safety studies. 16th National Conference Tension and hypertension. Investiture Ceremony Bangalore of the Association for Prevention and Control of Rabies in Society of Obstetrics. Bangalore Medical College, 20 April India, Mysore, 5-6 July 2014. 2014 (iii) (a) Neuroimaging and aphasia (b) Neuroimaging in dysarthria. Institute of Speech and Hearing, Bangalore, 209. Rawat N, Khanna M, Gupta A, Taly AB. Hand robotic therapy 20 August 2014 (iv) Functional MRI basics: MACE CME, in stroke patients. 43rd National Conference of IAPMR, NIMHANS, Bangalore, 21 September 2014 (v) Modulations Trivandrum, Kerala, 29 January-1 February 2015. in fMRI connectivity. Dr. Mahadevan Pillai Memorial CME on FMRI Seeking New Frontiers. NIMHANS, Bangalore, 23 210. Rayadurg V, Jagdevan S, Kamath S, Pandey P, Reddy MS. November 2014 (vi) fMRI in epilepsy. Indo German Seminar Is cerebral protection beneficial during bypass surgery for on Medical Imaging in Neurosciences: Diagnosis, Analysis and Moyamoya disease? 16th Annual National Conference of Treatment. NIMHANS, Bangalore, 4 December 2014 (vii) Indian Society of Neuroanaesthesiology and Critical Care, Neuroimaging at NIMHANS. Translational neuroscience in SGPGI, Lucknow, Uttar Pradesh, 30 January-1 February 2015. altered states of consciousness: linking neuroimaging of brain injury and anaesthesia for improved diagnosis and prognosis. 211. Reeta Mani , Dovih DP, Ashwini MA, Sanyal S, Chattopadhya NIMHANS, Bangalore, 6 March 2015. B, Garg K, Madhusudana SN. Surveillance for bat rabies in India: results of a pilot study. 16th National Conference of the 218. Sabitha K Rajesh. 17β-estradiol modulates glutamate induced Association for Prevention and Control of Rabies in India, calcium signaling and mitochondrial function in cortical Mysore, 5-6 July 2014. neurons. 60th Annual Conference of APPICON on Neural
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Plasticity in Health and Disease, Puri, Odisha, 20-22 November Oration) (vi) Magnetic encephalography: methods and 2014. application. 9th IES EEG Workshop–Case Based Basics to Advanced EEG Workshop, Hyderabad, 30 November 2014 219. Sadana D, Rajeswaran J, Jain S, Kumaran SS. A snapshot (vii) Dr.Krishnamoorthy Srinivas Lecture on Brain aging-can it of creative brain. National Conference on Cognitive and be prevented?, Celebrating 50 years in Community Neurology Neuropsychology: Challenges and Issues, Christ University, with a meeting of the Brain & Mind, Chennai, 5 December Bangalore, 14-15 November 2014. 2014 (viii) Chairperson, Delivered the Introductory Note, Epilepsy Expert Form (EEF), Bangalore, 21 December 2014. 220. Sadana D, Rajeswaran J. (i) (a) Brain development in children (b) Creativity – concepts & applications. FitKids, Bangalore, 3 227. Sathyaprabha TN (i) Evaluation of autonomic functions. February 2015. APPICON 2014,Cuttack, Orissa, 20-22 November 2014 (ii) Heart rate variability & its clinical aspects. 1st CME Physiology 221. Safvana P. MRI Safety. Karnataka Medical Radiographer in clinical practice, Raipur, 30 March 2015. & Allied Technologies Association State Level Conference, Mangalore, 8-9 February 2015. 228. Sathyaprabha TN, Sujan MU, Raghavendra Rao M, Ravikiran Kisan, Atchayaram Nalini, Raju TR. Influence of hydrotherapy 222. Sailaxmi Gandhi (i) Psychiatric in-patients perception of on clinical and cardiac autonomic function in migraine patients. impact of yoga on their health ANCIPS, Hyderabad, Andhra IANCON 2014, Chandigarh, 6-9 November 2015. Pradesh, 8-11 January 2015. 229. Satish Girimaji (i) Psychiatric problems in children in clinical 223. Sanivaram Reddy, Krishana Reddy N, Kodandarama. A study practice. Annual CME of General Practitioners’ Association, on psychosocial issues of women in police station–special Hubli, 20 April 2014 (ii) Developmental disorders in children reference to Bangalore City. 33rd Annual National Conference with special focus on learning disorders. CME organized of the Indian Society of Professional Social Work, Bharathiyar at Department of Psychiatry, Goa Medical College, 22-23 University, Coimbatore, Tamil Nadu, 28-30 January 2015. November 2014.
224. Sankaranarayanan H, Gupta A, Rawat N, Khanna M, Taly AB. 230. Satyakam Baruah, Akhil Deepika, Preethish Kumar V, Dhaval OPP induced myeloneuropathy: A case report. 43rd National P Shukla, Dhananjaya I Bhat, Sathyaprabha TN, Indira Conference of IAPMR, Trivandrum, Kerala, 29 January-1 Devi B. Demonstration of autonomic dysfunction following February 2015. brachial plexus injury using quantitative sudomotor axon reflex test [QSART]. 1st TS Srinivasan-NIMHANS Knowledge 225. Sasidharan A, Nair AK, John JP, Kutty BM. Patients with Conclave on Autonomic Dysfunction, NIMHANS, recent-onset schizophrenia show alterations in N100, N170 Bangalore, 12-13 February 2015. and P200 ERPs. International Symposium on Translational Neuroscience and 32nd Annual Conference of Indian Academy 231. Satyanarayana VA, Suman LN, Kavita Jangam. Setting up of Neurosciences, Bangalore, 1-3 November 2014. a trauma recovery clinic: addressing a critical need in India. 41st National Annual Conference of the Indian Association of 226. Sathishchandra P (i) Strengthening of mental health care Clinical Psychologists. Ahmedabad, 6-8 February 2015. physical infrastructure–establishment of new mental hospitals and upgradation of identified hospitals to centre of excellence. 232. Sayani Maji, Rajeshwari Shome, Netravathi M, Veenakumari National Conference on Mental Health and Human Rights, HB, Ranjitha, Nagarathna S, Sathishchandra P. Integrated India International Centre, New Delhi, 20 May 2014 (ii) microbiological and serological approaches in the diagnosis of Updates on genetics of epilepsy, Epilepsy Conclave 2014 neurobrucellosis and its correlation with clinical presentations. under the aegis of Indian Epilepsy Society and Indian Epilepsy IAMM (KC) Conference, Bangalore, 20 December 2014. Association, Goa, 12 July 2014 (iii) Technology addiction, The Bangalore Science Forum (Reg), Bangalore, 19 July 2014 (iv) 233. Sekar K (i) Overview on disaster situation and disaster Status epilepticus: Indian perspective, Neurovision, Chennai, management in India and Karnataka. Department of 27 July 2014 (v) Bridge over troubled water. International Community Medicine, Sri Devaraj Urs Medical College, Symposium on Translational Neurosciences & 32nd Annual Tamaka, Kolar, in association with NIMHANS National Nodal Conference of the Indian Academy of Neurosciences, Centre for PSS in Disaster Management, Bangalore. State NIMHANS, Bangalore, 1 November 2014 (Presidential Level Workshop on Disaster Management on Comprehend
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Thoroughly, Prepare Optimally & Respond Resolutely. 19 237. Shankaranarayana Rao BS (i) The ever changing brain and new September 2014 (ii) Symposium on Psychiatric Social Work, challenges in treating brain disorders. Rajah Mutthiah Medical on Inauguration of M.Phil., Programme in Psychiatric Social College, Annamalai University, Chidambaram, 6 March 2015 Work Course at IMHANS, Kozhikode, Kerala, 11 September (ii) The plastic brain: mold your brain the way you want. 2014 (keynote address) (iii) UGC Sponsored Seminar on UGC Refresher Course in Life Sciences for the Faculty, UGC Recent trends in Professional Social Work–Service, Training Academic Staff College, Bangalore University, Bangalore, 21 and Research. School of Social Work, Roshini Nilaya, February 2015 (iii) Stress is bad to the brain: novel therapeutic Mangalore, 25 September 2014 (iv) Disaster management from approaches to treat stress-induced brain dysfunctions. National social work perspective. UGC Sponsored National Seminar on Conference on Stress and Health: Frontiers of Research Organised by Department of Social Work, SBRR Mahajana in Stress Related Diseases and Management. Maharani’s First Grade College, Pooja Bhagavat Memorial Mahajana Science College for Women, Bengaluru, 12-13 February Education Centre, Mysore, 11 October 2014 (v) Mental 2015 (iv) The plastic brain: a tool to treat neurological and health enrichment training for community differently abled psychiatric disorders (a) DST - INSPIRE Internship Science welfare facilitators. Puthuvaazhu Project, Government of Tamil Camp. School of Biotechnology, Vignan’s University, Guntur, Nadu, 5 November 2014 (vi) Psychosocial first aid training Andhra Pradesh, 3-7 June 2014 (b) 102nd Indian Science in Kashmir. Disaster Management and Mitigation Unit, Congress. University of Mumbai, Mumbai, 3-7 January 2015 Emmanuel Hospital Association, New Delhi, 20-22 November (v) (a) Synaptic plasticity: activity-dependent rewiring and 2014 (vii) International classification of functioning, health in remodelling of brain circuits (b) Neural plasticity: a tool to treat India. Workshop at Sanjay Gandhi Institute of Trauma and brain disorders. Brain Circuits, SERB School in Neuroscience Orthopaedics, Bangalore, 13 February 2015. VIII, IISER Pune, 8-21 December 2014 (vi) Neural plasticity and novel therapeutic approaches to treat cognitive deficits 234. Sekar K, Kavita Jangam, Aravind Raj E. Symposium on in neurological and psychiatric disorders. ICMR Sponsored Training of trainers on psychosocial preparedness in disaster National Seminar on Cognitive Brain and Issues. Indo- management for schools of social work. 33rd Annual National American College, Cheyyar, 11 April 2014 (vii) The plastic Conference of Indian Society of Professional Social Work, brain and challenges in treating brain disorders. Refresher Bharathiyar University, Coimbatore, 28-30 January 2015. Course in Life Sciences. Division of Biological Sciences, School of Natural Science, Bangalore University, Bangalore, 11 April 235. Senthil A (i) Sample size estimation. Workshop on 2014. Epidemiology and Statistics Simplified, organized by Department of Community Medicine, BMCRI and Quit 238. Sharma M. Technology addiction and mental health. Tobacco India Project,11 April 2014 (ii) National mental Symposium on Cyberpsychology, Gujarat Forensic University, health programme–monitoring & evaluation. Workshop on Gujarat, 22 February 2015. Integrating Management of Neuropsychiatric Problems into NCD Care for Medical officers in Kolar organized by District 239. Sharma MP (i) (a) Cognitive behavioural perspective of sexual Health Department, Kolar and Department of Epidemiology health: from conditioning to deconditioning (b) Approaches to in Kolar, 19 March 2015 (iii) Vision and locomotor disability. sex therapy – sensate focus. Workshop on Cognitive Behaviour Workshop on Home Based Care of Children with Special therapy in sexual dysfunctions. NIMHANS, Bangalore, 25- Needs for Volunteers of Sarva Siksha Abhiyan, organized 26 July 2014 (ii) Nature and relevance of life skills education; by Dept. of Epidemiology, Dept. of Child & Adolescent mindfulness-based intervention in stress management. State Psychiatry, Dept. of Speech Pathology & Audiology, Level Symposium on Life Skills Counselling. National Degree NIMHANS in collaboration with Sarva Siksha Abhiyan, College, Bangalore, 17 September 2014 (iii) (a) Understanding Kolar District, 25-27 March 2015. the mindfulness perspective in stress management. Workshop on De-Stressing Mindfully: Managing Work Stress. NIMHANS 236. Shankar SK (i) Diagnosis of CNS infections-is there a light Centre for Well Being, Bangalore, 23 August 2014 (iii) at the end of the tunnel? CME in Neuropathology, SVIMS, Mindfulness perspective in stress management. Workshop on Tirupati, 26 October 2014 (ii) Understanding neuroscience De-stressing Mindfully: Managing Work Stress for Air Force through the looking glass of human anatomical pathology. Prof. personnel. NIMHANS Centre for Well Being, Bangalore, 26 Mehdi Hasan Memorial Lecture, 32nd Annual Conference of September 2014 (iv) Sessions on cognitive behaviour therapy: Indian Academy of Neurosciences, NIMHANS, Bangalore, 3 an introduction; assessment in CBT: methods and strategies; November 2014. cognitive behavioral management of depression. Workshop on
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CBT: Principles and Applications. NIMHANS, Bangalore. 245. Shivashankar N. Applications in diagnosis & intervention in 30-31 October 2014 (iv) Sessions on mindfulness-based speech language pathology and audiology. Ethical issues in AV interventions: an introduction; sitting mindfulness meditation; recording ISHA-BC Conference on Audio-Video Methods– mindfulness integrated CBT in OCD; body scan meditation; from Recording to Analysis, NIMHANS, Bangalore, 11-12 raisin exercise, mindful walking and mindfulness of sound. October 2014. Workshop on Mindfulness-Based Cognitive Behavioural Interventions: Applications in Clinical and Non-Clinical 246. Shoba Srinath (i) Autism spectrum disorders and epilepsy. Settings. (a)NIMHANS, Bangalore, 21-22 November Indian School of Epilepsy, Hyderabad 14 September 2014 2014, 1 March 2015 (b) Smt. Kapila Khandvala College (ii) Behavior management of children with special needs for of Education, Mumbai, 13-14 March 2015 (vi) Cognitive the faculty and students of the Bangalore Institute of Dental behavioural perspective of OCD: an overview; moving towards Sciences, 8 December 2014 (iii)(a) ASD-current issues and role metacognitions: mindfulness-integrated cognitive behaviour of early interventionists (b) Comprehensive overview of autism, therapy in the management of OCD. Workshop on Cognitive Five day Certificate Training Programme on ASD-Current Behaviour Therapy for Obsessive Compulsive Disorder. Issues and Role of Early Interventionists, organised by the Com NIMHANS, Bangalore, 23-24 January 2015 (vii) Third DEALL Trust, Bangalore, 18 August 2014 (iv) Concerns and generation cognitive behavioural interventions. Symposium on issues in the upbringing of adolescents. Faculty and students Psychology–Challenges and Perspectives. NMKRV College for of the Armed Forces Medical College, Pune, 21 August 2014 Women, Bangalore, 29 January 2015. (v) Developmental disorders. Post graduates of the Depts. of Psychiatry and Paediatrics, AFMC, Pune, 22 August 2014 (vi) 240. Shastry AH, Balaram Thota, Shwetha Durgad, Kandavel Impact of a child with ASD on the family. Training programme Thennarasu, Arimappamagan Arivazhagan, Vani Santosh. organised by the Karnataka Parents Association for Mentally STAT1 is a novel invasive marker associated with poor prognosis retarded citizens for teacher trainees in their course on Autism. in p53 positive glioblastoma patients. ISNOCON 2014, 6th Indian Society of Neuro Oncology Conference, Lucknow, 247. Shree Mishra, Murthy P. Substance abuse among women: A 2014. health and socioeconomic perspective. National Seminar on Women Empowerment and Inclusive Growth, Jaipur. ICSSR, 241. Shayanki Lahiri Mukhopadhyay, Chetna Sharma, Veena 13-14 March 2015. Kumari HB, Netravathi M, Sayani Mazi, Nagarathna S, Sathishchandra P. Characterization, virulence determination 248. Shripad A. Patil. Global challenges in management of parasitic and antifungal susceptibility profile of cryptococcus gattii from diseases. 25th Indian Society of Parasitology, Lucknow, 16-18 the patients of cryptococcal meningitis in a tertiary neuro-care October 2014 (ii) Immunodiagnosis of tuberculous meningitis hospital in south India. IAMM (KC) Conference, Bangalore, correlation with culture, significance and pit falls–A 20 years 20 December 2014. study. 41st Annual Meeting of Immunology, Madurai, 12-14 December 2014. 242. Shayanki Lahiri Mukhopadhyay, Netravathi M, Chetna Sharma, Veena Kumari HB, Nagarathna S, Sathishchandra 249. Shriram Varadharajan, Gupta AK, Saini J, Arvinda HR. P. Central nervous system infection due to cryptococcus Endovascular management of post traumatic intracranial AV neoformans variety gattii: an overview of clinical and shunts in children. ISPR, Vellore, 12-13 September 2014. microbiological characterization. IAMM (KC) Conference, Bangalore, 20 December 2014. 250. Shriram Varadharajan, Gupta AK, Ullas VA, Saini J, Arvinda HR.(i) Unravelling the mystery of the coil–a trip down 243. Shekhar Seshadri (i) Special issues in children. Ministry of memory lane. Neurovascon 2014, NIMHANS, 5-7 September Health & Family Welfare RBSK Programme, New Delhi, 2014(ii) Angiographic and hemodynamic predictors of clinical 19 June 2014 (ii) Mathaias Memorial Lecture. PAMRC, 10 outcome in ICA aneurysms during balloon test occlusion–a September 2014 (iii) Emotional behavioural issues in children Retrospective Review. ISNR 2014, New Delhi, 9-12 October affected/infected by HIV. Karnataka Health Promotion Trust, 2014. Bangalore, 30 January 2015. 251. Shriram Varadharajan, Gupta AK, Ullas VA, Saini J. CT 244. Sheshagiri. REM sleep abnormalities in auto spinocerebellar angiography in acute ischemic stroke - (Looking beyond the ataxias. 8th Asian Sleep Research Society Congress, obvious). Third International Day of Radiology, New Delhi 8 Kovalam, Kerala, 22- 24 September 2014. November 2014.
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252. Shwetha C, Sonam K, Bindu PS, Taly AB, Gayathri N, Bangalore, 7-9 March 2015 (xx) Investigation of drug resistant Srinivas Bharath MM, Govindraj C, Aravinda HR, Madhu epilepsy. NIMHANS-Maastricht University, Bangalore, 13- N, Sinha S, Khan NA, Govindraj P, Paramasivam A, 14 March 2015. Thangaraj K. Chronic progressive external ophthalmoplegia: clinical, histopathological, biochemical and genetic 256. Sinimol Wilson. Basic principles of digital subtraction observations in 56 patients from a tertiary care university angiography (DSA), Karnataka Medical Radiographer & Allied hospital in south India. 4th Annual Conference of Society for Technologies Association State Level Conference, Mangalore, Mitochondrial Research & Medicine, Manipal University, 8-9 February 2015. Manipal, December 2014. 257. Sivakumar PT, Sridatta R, Nagalakshmi RM, Sugandhi ASM, 253. Shwetha C, Sonam K, Khan NA, Govindraj P, Govindraj C, Thennarasu K, Keshav Kumar J. et al. Cognitive function in Bindu PS, Taly AB, Gayathri N, Aravinda HR, Bharath S, elderly with late onset depression: a cross sectional study. 17th Madhu N, Sinha S, Thanagraj K. Complete cytochrome C Asia Pacific Regional Conference of Alzheimer’s Disease oxidase deficiency in children: a clinical, magnetic resonance International, New Delhi, 7-9 November 2014. imaging and genetic study from NIMHANS, India. 32nd Annual Conference of Indian Academy of Neuroscience- 258. Sivakumar T, Chethan B, Thirthalli J, Pathak A, Ahammed A, Translational Research: Novel Approaches to treat Neurological Sujai R, James JW, Reddy RP, Vijayan TV, Kumar CN, Gandhi and Psychiatric disorders. NIMHANS, Bangalore, November S, Nirmala BP, Bhola P, Kumar D, Desai G, Chaturvedi SK. 2014. Caregivers support and education programme workshops: NIMHANS experience. 5th Asia Pacific Regional Conference 254. Singh H, Reddi VSK, Chandra PS. Clinical correlates of suicide on Psychosocial Rehabilitation, Bengaluru, 6-8 February 2015. in psychiatric patients with high suicidal risk. 67th ANCIPS, Hyderabad, 8-11 January 2015 (Young Psychiatrist Award). 259. Sonam K , Govindaraj P, Khan NA, Govindaraju C, Shwetha C, Bindu PS, Taly AB, Gayathri N, Srinivas Bharath M, 255. Sinha S (i) Epilepsy-video based Workshop. 3rd IAN Nagappa M, Sinha S, Thangaraj K. Novel mitochondrial DNA postgraduate summer course in Neurology-2014, Bangalore, mutations in patients with mitochondrial disorders: a study on 10-13 April 2014 (ii) Status epilepticus: management. Epilepsy 105 patients from a tertiary care university hospital from south Conclave, Goa, 12-13 July 2014 (iii) (a) Progressive myoclonic India. International Symposium, Translational Neuroscience epilepsy (b)Epilepsy treatment and systemic diseases Indian & 32nd Annual Conference of the Indian Academy of Epilepsy School, Hyderabad, 1-14 September 2014 (iv) Neurosciences, NIMHANS, Bangalore, 1-3 November 2014. Epilepsy: Indian scenario. International Symposium on Translational Neuroscience & 32nd Annual Conference of the 260. Sonam K, Bindu PS, Taly AB, Srinivas Bharath MM, Indian Academy of Neurosciences, Bangalore, 1-3 November Gayathri N, Aravinda HR, Madhu N, Sinha S, Govindaraj P, 2014 (v) (a)Video-based presentation of seizure semiology Paramasivam A, Thangaraj K. Mitochondrial respiratory chain (b) Pre-surgical evaluation of drug resistant epilepsy (c) disorders in childhood: insights into phenotypes, biochemical Treatment approaches to epilepsy: critical appraisal. Epilepsy and molecular diagnosis in eighty five children from a tertiary CME, Jamshedpur, 23 November 2014 (vi) (a) MEG and care university hospital in south India. 4th Annual Conference epilepsy-case based approach, EEG (b) Invasive recording- of Society for Mitochondrial Research and Medicine, Manipal, case (c) EEG in generalized epilepsy (d) EEG of benign non- 8-9 December 2014 (Best Poster Award). epileptiform discharges EEG Workshop (IES), Hyderabad, 29-30 November 2014 (vi) Pre-surgical evaluation of drug 261. Soundarya Soundararajan, Gitanjali Narayanan, Arpana resistant epilepsy. Indo-Japan Collaborative Workshop by Agrawal, Dorairaj Prabhakaran, Pratima Murthy (i) Personality NIMHANS-Osaka University, Bangalore, 7 January 2015 dimensions and their association with treatment outcome in (vii) Status epilepticus: management. 6th NSI Educational alcohol dependent patients. 67th Annual National Conference Course, Bangalore, 30-31 January 2015 (viii) Management of of the Indian Psychiatric Society, 11 January 2015(ii) Age at elderly seizures. ECON 2015, Bangalore, 6-8 February 2015 first drink & its association with later life drinking patterns in (ix) Autonomic dysfunction in epilepsy. TSS-NIMHANS alcohol dependent patients. 32nd Annual Conference of Indian Conclave on Autonomic Dysfunction, Bangalore, 12-13 Academy of Neurosciences, NIMHANS, 1-3 November 2014. February 2015 (ix) Epilepsy research experience & MEG at NIMHANS. Translational Neuroscience in Altered State 262. Sowmya S, Arasappa R, Muralidharan K. Acute ECG changes of Consciousness DST-Royal society Scientific Seminar, with quetiapine in two patients with bipolar disorder. 5th
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Annual Conference of the Society for Bipolar Disorders–India, 2014 (ii) Chaired a scientific session in National Seminar on SBDI 2014, Bangalore, 14 December 2014. Madhumeha Jignasa, Sri Sri Ayurvedic College, Kanakapura Road, Bangalore, 6 June 2014. 263. Soyuz J, Dhanasekarapandian R. (i) Adolescents: social determinants of health and psychosocial theories. National 269. Subhra Prakash Mallick. Utility of T1W SPACE/CUBE/ Seminar on Social Work Practice: Scope and Challenges in VISTA in head & neck imaging. National Conference of the the Present Context, Department of Social Work, Kurukshetra Indian Society of Radiographers & Technologists, Kovalam, University, Kurukshetra, Haryana, 14-15 November 2014 (ii) Trivandrum, Kerala, 13-14 December 2014. Perception of college faculties about health related behaviours of college students. 33rd Annual National Conference of 270. Subramanian S. Therapeutic strategies to Alzheimer’s disease. the Indian Society of Professional Social Work, Bharathiyar 28th Annual Meeting of Society for Neurochemistry, India University, Coimbatore, Tamil Nadu, 28-30 January 2015. (SNCI) and National Conference on Neurodegenerative Disorders and Metabolic Diseases, Sri Ramachandra University, 264. Sriganesh K, Gopalakrishna KN. Conducted Neurocritical Chennai, 10-12 September 2014. Care Workshop on Cerebral Oxygenation. 21st Annual Indian Society of Critical Care Medicine Conference, Bangalore, 5 271. Sudeep Jacob Joseph, Thirumoorthy A, Sekar K, Santosh March 2015. Loganathan. Techniques for brief strength based social case work among persons with depression. 33rd Annual National 265. Sriganesh K, Masud Ahmed, Umamaheswara Rao GS. Conference of the Indian Society of Professional Social Work, Acute kidney injury in traumatic brain injury. 23rd Annual Bharathiyar University, Coimbatore, Tamil Nadu 28-30 January Neurotrauma Conference, Mussoorie, Uttarakhand, 30 August 2015. 2014. 272. Sudhir PM (i) Mindfulness based stress reduction. Conference 266. Sriganesh K. Bad lung in a patient with bad brain. 62nd Annual on stress reduction skills: scientific update. Sri Sri Global ISACON 2014, Madurai, 29 December 2014 (ii) Preanaesthetic Meditating Doctors Association, New Delhi, 30-31 August evaluation of patient with CNS disorder. 10th Annual CME, 2014 (ii) Behavioural addiction-psychological approaches MMC, Mysore, 7 December 2014 (iii) Traumatic brain injury to management. SIPSOCON 2014, Kerala Psychiatric AND panel discussion on Trauma. ISA-CME, MRMC, Association, Kochi, Kerala, 26-28 September 2014 (iii) Gulbarga, 28 September 2014. Effective management of stress. UGC Sponsored National Conference on Stress and Health: Frontiers of Research in 267. Srikala Bharath (i) Communicating with family members Stress Related Diseases and Management, Bangalore, 12-13 across life span. Workshop on Family Centered Perspectives February 2015 (iv) (a) Exposure and response prevention.CBT in Developmental Disabilities. Spastic Society of Karnataka, for OCD organized by the Department of Clinical Psychology, Bangalore, 23 August 2014 (ii) Sensitization Workshop on NIMHANS, Bangalore, 23-24 January 2015 (b) Seminar the Empowerment through Life Skills Education towards organized by Chethana Hospital, Secunderbad, 8 March 2015 Prevention of Substance Abuse in the Orientation Program (v) Role of psychologist in community mental health-Panel on Substance Abuse by the Center for Addiction Medicine, Discussion of Multi disciplinary Approach in Community NIMHANS Bangalore, 22 November 2014 (iii) Sensitization Mental Health Nursing. Workshop on Community Mental Workshop on the Empowerment through Life Skills Education. Health Nursing, College of Nursing, NIMHANS, Bangalore, UGC sponsored National Level Workshop on Nurturing 31 March 2015. You, Me & We: Positive Mental Health for Personal and Social Empowerment. Smt. Khandvala College of Education, 273. Sujan MU , Akhil Deepika, Shilpa Mulakur, Satyaprabha TN. Mumbai, 13 March 2015 (iv) Life style and wellbeing of the Effect of bhramari pranayama (humming bee breath) on heart elderly in the community. ICMR-FORTE Joint Workshop on rate variability, blood pressure and heart rate–a pilot study. 1st Health and Aging, ICMR, New Delhi, 24-25 November 2014. TS Srinivasan-NIMHANS Knowledge Conclave. Autonomic Dysfunction, NIMHANS, Bangalore, 12-13 February 2015. 268. Srinibash Sahoo (i) Evidence based intervention for improving child mental health and their application in public health 274. Sultan Yusufi. CT generations. Karnataka Medical system. Students of Master in Public Health Programme. Radiographer & Allied Technologies Association State Level Dept. of Epidemiology, NIMHANS, Bangalore, 19 June Conference, Mangalore, 8-9 February 2015.
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275. Suman LN (i) Crisis counseling. Top and middle management NERVECON 2014, Hyderabad, 2-3 August 2014 (ii) personnel of Accenture, Bangalore, 20 May 2014 (ii) Living Autonomic dysfunction in neurological emergencies. with schizophrenia. Psychology Society Programme for 2014- Autonomic Dysfunction: An Interdisciplinary Workshop 2015, World Mental Health Day, Department of Psychology, for Clinicians and Scientists. TS Srinivasan-NIMHANS Bangalore, 10 October 2014 (iii) Psychological trauma: the Knowledge Conclave 2015, NIMHANS, Bangalore, 12-13 invisible scars. UGC Sponsored National Seminar on Health February 2015. and Well-Being, Symbiosis College, Pune, 19-20 December 2014 (iv) Cyber trauma. National Seminar on Cyber Psychology 282. Tanmay Jadhav, Madhusudan Reddy KR, Sriganesh K, organized by the Institute of Behavioural Science, Gujarat Sudhir V, Jagadisha T, Naveen Kumar C, Shyam Sundar Forensic Sciences University under the aegis of Bureau of Police A. Asystole during electroconvulsive therapy; a case report. Research & Development, Ministry of Home Affairs, Govt. of Indian Psychiatric Society-South Zone Conference, Bangalore, India, Gandhinagar, Gujarat, 20- 21 February 2015 (v) UNDP October 2014. sponsored Consultation Workshop on Gender Based Violence and Safe City, organized by Swasti Health Resource Center, 283. Tansa KA, Jangam K, Muralidharan K. Childhood abuse Bangalore, 24 March 2015. among women diagnosed with bipolar disorder, unipolar depression and healthy controls: a prospective study. 5th Annual 276. Sumitha R, Alladi PA, Nalini A, Sathyaprabha TN, Raju Conference of the Society for Bipolar Disorders–India, SBDI TR. Directed differentiation of human embryonic stem cells 2014, Bangalore, 14 December 2014. into motor neurons, their characterization & use as a cellular model for sporadic amyotrophic lateral sclerosis, for the 284. Thirumoorthy A, Thennarasu K, Saraswathi Devi. Burden Dutch Minister of Economic Affairs and Dutch Grants office among caregivers of cancer patients, 32nd Annual National NWO Director, Maastricht University, Maastricht Education Conference of Indian Society of Professional Social Work, Research Centre Pvt. Ltd, Bangalore, 1 April2015. Bharathiyar University Coimbatore, 28-30 January 2015.
277. Sundar Periyavan (i) Donor screening. 39th National 285. Thomas Gregor Issac, Akhil Deepika, Satyaprabha TN, Conference of ISBTI, Patiala, Punjab, 17-19 October 2014 Chandra SR. Autonomic dysfunction in frontotemporal (ii) TPE in Indian Scenario. CME program, Bangalore dementia-a pilot study 1st TS Srinivasan- NIMHANS Neurological Society, Bangalore, 19 November 2014 (iii) TPE Knowledge Conclave on Autonomic Dysfunction, NIMHANS. in Neurological Diseases. Two Day Seminar of 1st South Zone Bangalore, 12-13 February 2015. Meet 2015, Kodaikanal, Tamil Nadu, 27-29 March 2015. 286. Thomas Gregor Issac. Organization of rare diseases India. 278. Suresh Parmar (i) Neuroanatomy and basic neurophysiology. CME Programme-2015 on Rare Diseases- A Practical Training for 7th National Brain Bee Championship Participants Approach, Bengaluru, 5 April 2015. – Sevenhills Hospitals, Marole, Mumbai, 19-20 April 2014 (ii) Weeklong anatomy and kinesiology (basic & regional) Training 287. Thomas Gregor Issac, Chandra SR. Transcranial magnetic to the trainees Hatha Yoga Teacher Training Course–Mystic stimulation as an early biomarker to differentiate between early Yoga School, Mysore, 2-7 March 2015. Alzheimer’s disease and fronto temporal dementia. 1st IBRO APRC, Chandigarh Neuroscience School, Chandigarh (Best 279. Sutar R, Ray A, Sheshadri SP. Leucodystrophy imitating ADHD Poster Presentation). & Mania. IPSOCON 2014, Bangalore, 19 October 2014. 288. Tiwari SK. orientation to this centre, Students of Master 280. Suwarna Chakraborty, Tripathi SJ, Raju TR, Shankaranarayana in Public Health Programme. Dept. of Epidemiology, Rao BS. Depression-induced cognitive deficits are restored NIMHANS, Bangalore, 21 June 2014. by chronic treatment with N-acetyl cysteine. Proceedings of the National Conference on Stress and Health: Frontiers 289. Tripathi SJ, Suwarna Chakraborty, Raju TR, Shankaranarayana of Research in Stress Related Diseases and Management. Rao BS. Chronic stress-induced cognitive deficits are associated Maharani’s Science College for Women, Bengaluru, 12-13 with abberant glial morphology and hypotrophy of the prefrontal February 2015. cortex. National Conference on Stress and Health: Frontiers of Research in Stress Related Diseases and Management. 281. Taly AB (i) Pitfalls in the diagnosis of leprosy. 2nd Maharani’s Science College for Women, Bengaluru, 12-13 International Symposium on Peripheral Nerve Disorders. February 2015.
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290. Ullas VA. History and evolution of the CNS endovascular in MELAS syndrome. 3rd Annual Conference of Society for gemstone, ONYX. Neurovascon 2014, NIMHANS, 5-7 mitochondrial research and medicine. Bangalore, December September 2014 (ii) Spinal dysraphism illustrated- embryology 2014. revisited. ISPR, Vellore, 12-13 September 2014 (iii) Ct guided percutaneous vertebral body biopsy- our experience in spine 296. Vandana VP, Bindu PS, Sonam K, Govindraj P, Gayathri N, mining. ISNR 2014. New Delhi, 9-12 October 2014. Govindraj C, Arvinda HR, Nagappa M, Sinha S, ThangarajK, Taly AB. Audiological manifestations in mitochondrial 291. Umamaheswara Rao GS (i) Respiratory care for neuroclinicians. encephalomyopathy lactic acidosis and stroke like episodes Neurological Society of India. Coimbatore, 11 December 2014 syndrome. 4th Annual Conference of Society for Mitochondrial (ii) Panel Discussion on Management of cerebral ischemia. Research and Medicine. Manipal, December 2014. Neurovascon, Bangalore, 5 September 2015 (iii) Neurological monitoring. CME in Fortis Medical Centre. Bangalore, 29 August 297. Vandana VP, Bindu PS, Sonam K, Taly AB, Govindraj 2015 (iv) Strategies for preconditioning and their feasibility. P,Gayathri N, Govindraj C, Arvinda HR, Nagappa M, Sinha S, Annual Conference of the Indian Society of Neuroanaesthesia Thangaraj K. Speech-language manifestations in mitochondrial and Critical Care, 30 January 2015 (v) Organisation of the disease–Comparison of MERRF and MELAS syndrome. Neurocritical Care Workshop as a part of the Indian Society International Symposium on Translational Neuroscience of Critical Care Medicine Annual Conference, Bangalore, & 32nd Annual Conference of the Indian Academy of 4-9 March 2015 (vi) Anaesthetics and autonomic function. Neurosciences, Bangalore, 1-3 November 2014. TS. Srinivasan Knowledge Conclave 2015 on Autonomic Dysfunction, 12-13 February 2015 (vii) Translational Research in 298. Vani Santosh (i) Clinicopathologic Conference. Neurological Anaesthesia. Benares Hindu University. Varanasi, 15 June 2015 Society of India– Kerala Chapter (NSIKC), Trivandrum, 28 (viii) Hypothermia in the ICU–How to cool and when to cool. February-1 March 2015 (ii) Pathology of gliomas-an update, CME Programme organised by Medanta Medicity, New Delhi, Slide sessions on Pediatric Brain Tumors and Glioneuronal 26 April 2014 (ix) A practical approach to mechanical ventilation Tumors. CME Program in Neuropathology, MS Ramaiah in neurosurgical patients. Symposium on Neuroanaesthesiology Medical College, Bangalore, 14 March 2015 (iii) Pathological and Neurocritical Care, Fortis Hospital, Gurgaon, New Delhi, and molecular diagnostics of pediatric low grade tumours. 28 January 2015 (x) Research in anaesthesia. Abbott Asia Symposium in Neurooncology in Collaboration with World Anaesthesia Summit 2014, Mumbai, 19-20 April 2014. Federation of Neurosurgery Course, Mumbai, 7-8 January 2015 (iv) (a) Glioma-evolution from morphology to molecular 292. Vandana VP, Bindu PS, Arun B Taly, Gayathri N, Madhu N, diagnostics, is it needed? (b) Conducted CPC Programme, Sinha S. Speech-language characteristics in mitochondrial NSICON 2014, 63rd Annual Conference of Neurological disease–Comparison of MERRF and MELAS syndrome. 32nd Society of India, Coimbatore, 12-15 December 2014 (vi Annual Conference of Indian Academy of Neurosciences. Pathology of gliomas and slide session on neoplastic lesions Bangalore, December 2014. of the brain. PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore, 12 December 2014 (vi) Molecular 293. Vandana VP, Bindu PS, Sonam K, Arun B Taly, Gayathri pathology of low grade gliomas. Neurooncology CME, N, Madhu N, Sinha S. Speech-language and swallowing Department of Radiation Oncology Cancer Institute, Swamy manifestations and rehabilitation in a child with MELAS- Rama Himalayan University, Dehradun, 4 October 2014 (vii) Leighs’ overlap syndrome. 3rd Annual Conference of Society Pathology of gliomas and embryonal tumors. CME program for Mitochondrial Research and Medicine. Bangalore, in Neuropathology, Bangalore Medical College and Research December 2014. Institute, Bangalore, 12 October 2014 (viii) Stereotactic biopsy interpretation and problems. STERIOCON 2014, 294. Vandana VP, Bindu PS, Sonam K, Gayathri N, Arvinda NIMHANS, September 2014 (ix) Molecular stratification of HR, Nagappa M, Sinha S, Taly AB, Speech-language and anaplastic grade III gliomas-Clinical Relevance. 6th Annual swallowing dysfunction and rehabilitation in a patient with Conference Indian Society of Neuro-Oncology, Lucknow, 11- MELAS-leighs overlap syndrome. 4th Annual Conference of 13 April 2014. Society for Mitochondrial Research and Medicine. Manipal, December 2014. 299. Varambally S, Gangadhar BN, Thirthalli J, Jagannathan A, Kumar S, Venkatasubramanian G, Muralidhar D, Subbakrishna 295. Vandana VP, Bindu PS, Sonam K, Arun B Taly, Govindraj P, DK, Nagendra HR. Therapeutic efficacy of add-on yogasana Gayathri N, Madhu N, Sinha S. Audiological manifestations intervention in stabilized outpatient schizophrenia: randomized
298 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
controlled comparison with exercise and waitlist. NAMSCON Technology for Disaster Management Jointly organized by 2014, AIIMS Rishikesh, 19 October 2014. (Dr. Vimla Virmani Karnataka Science and Technology Academy and School of Award 2014) Earth Science, Central University of Karnataka, Gulbarga, Dr. S.M. Pandit Rangamandir, Kalaburagi, 22-23 January 2015. 300. Varambally S, Gangadhar BN. Yoga therapy for severe mental disorders. WAPR 5th Asia Pacific Regional Conference on 309. Vikas Dhiman. Next generation sequencing and Bioinformatics Psychosocial Rehabilitation. Bengaluru, 6-8 February 2015. Conference (NGBT) in NIMHANS, Bangalore, 17-18 November 2014. 301. Varambally S, Venkatasubramanian G, Gangadhar BN. Yoga and neuroplasticity in schizophrenia. IConS VI of SCARF 310. Vikas V (i) Visualisation for microneurosurgery: The way 2014, Chennai, 21-23 August 2014. ahead. Bioengineering Seminars, Indian Institute of Science, Bangalore, 8 May 2014 (ii) A clinical problem of destiny 302. Varambally S. Yoga therapy for schizophrenia. 29th Annual tracking of white fiber tracts. CUTECMIA 2014, Adishankara Conference of the IPS-Tamil Nadu Branch (TANPSYCON Institute of Engineering and Technology, Kalady, Cochin, 2014) Tiruchirapalli, 26-27 July 2014. 6-9 August 2014 (iii) Post operative care and complications. 7th NSI Educational Course, NIMHANS, Bangalore, 31 303. Varghese AM, Sharma A, Mishra PS, Vijayalakshmi K, Harsha January-1 February 2015. HC, Sathyaprabha TN, Nalini A, Alladi PA, Bharath MMS, Raju TR. Chitortiosidase, a putative biomarker of amyotrophic 311. Vinayak K. Common adolescent mental health issues. 13th lateral sclerosis intercedes neurodegeneration in spinal motor Batch Graduation Ceremony of Samadhan Centre for neurons via neuro-inflammation. 32nd Annual Conference of Counselling and Life Skills,Malleswaram, Bangalore, 22 Indian Academy of Neuroscience, NIMHANS, Bengaluru, 1-3 February 2015. November 2014 (Tulsabai Somani Educational Trust Award). 312. Vivek Benegal (i) Technology addiction: who is vulnerable? 304. Veena Kumari HB. MRSA colonization-a three year experience National Seminar on Cyberpsychology, Gandhinagar, February with a surveillance programme in a tertiary neurocare centre. 2015 (ii) Neurobiology of Addiction. CME on Addiction IAMM (KC) Conference, Bangalore, 20 December 2014. Medicine, Hubbali, February 2015 (iii) Epigenetics in addiction: from birth to the pub. Annual National Conference 305. Venugopal D, Shivakumar V, Kalmady SV, Subbanna of the Indian Association of Private Psychiatrists, Kochi, M, Agarwal SM, Narayanaswamy JC, Debnath M, November 2014 (iv) Colloquium on Neural Basis of Addiction. Venkatasubramanian G. Effects of gender on the relationship Indian Academy of Neurosciences, Bangalore, November 2014 between IL6 promoter polymorphism and lymphocyte gene (v) Behavioral Addiction, CME of the Annual Conference expression in schizophrenia. 40th Annual Conference of of the Kerala Psychiatric Society, Kochi, September 2014 (vi) Indian Society of Human Genetics, National Institute of Workshop on Motivational Interviewing, Sun CME, Nainital, Immunohaematology, Mumbai, 28-30 January 2015. September 2014 (vii) Etiology of addictive disorders. Sun CME, Gangtok, August 2014 (viii) Behavioral Addictions. Psychiatry 306. Vidhyasagar K. Overcoming anxiety in social situations a Club, Kolkata, July 2014 (ix) Consultation on Designing a workshop on understanding and managing social anxiety. Communication Strategy for the Rashtriya Kishore Swasthaya NCWB, Bangalore, 1 May 2014. Karyakram, New Delhi, June 2014 (x) Behavioral addiction, CME of the Annual Conference of the Kerala Psychiatric 307. Vidyadhara DJ, Yarreiphang H, Raju TR, Phalguni Anand Society, Kochi, September 2014. Alladi. Nigral dopaminergic neuronal phenotype in two mice strains with differential susceptibility to 1-methyl-4-Phenyl- 313. Vrinda M, Arun S, Nair KP, Kutty BM, Rao BSS. Levetiracetam 1,2,3,6-tetrahydropyridine (MPTP). International Symposium decreases seizure frequency and ameliorates temporal lobe on Translational Neuroscience and 32nd Annual Conference epilepsy induced cognitive deficits. International Symposium of the Indian Academy of Neuroscience, Bangalore, 1-3 on Translational Neuroscience and 32nd Annual Conference November 2014. of Indian Academy of Neurosciences, NIMHANS, Bangalore, 1-3 November 2014. 308. Vigneshwaran K, Palash Mandal, Sekar K, Aravind Raj E. Impact of psychological first aid on survivors of building collapse 314. Yarreiphang H, Vidyadhara DJ, Abhilash Parli, Raju TR, –Moulivakkam, Chennai. Regional Conference on Science and Phalguni Anand Alladi. Developmental Bax: Bcl-2 ratio differs
National Institute of Mental Health and Neuro Sciences 299| Annual Report 2014-15
in 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) 4. Bhola P. Workshop on Recovery Oriented Services (ROSes) for resistant and susceptible mice strains and their crossbreds. Ward Supervisors and Staff Nurses. Psychiatry Rehabilitation International Symposium on Translational Neuroscience Services, NIMHANS, Bangalore, 24 March 2015 (ii) Employee and 32nd Annual Conference of the Indian Academy of mental health; employee suicide. Workshop on Workplace Neuroscience, Bangalore, 1-3 November 2014. Mental Health: Creating Awareness, Building Skills. NCWB, Bangalore, 19-20 February 2015 (iii) Workshop on Revisiting 315. Yasha TC (i) Rapid intraoperative diagnosis-problems faced Doctor Patient Communications for Clinical Neuroscientists. by the neuropathologist. Symposium on Changing Trends NCWB, Bangalore, 2 January 2015 (iv) Caregiver Support and in Diagnostic Neuropathology and Diagnostic Implications. Education Workshops. Psychiatric Rehabilitation Services. NSICON 2014, Coimbatore, 12-15 December 2014 (ii) Cross NIMHANS, 16 September 2014, 16 December 2014, 20 sectional anatomy of brain. CME on Cross Sectional Anatomy January 2015, 17 February 2015. of Brain and its Applied Aspects. MVJ Medical College and Research Hospital, Hoskote, 23 September 2014. 5. Bindu M Kutty. Brain and the concept of cognitive reserve. National Workshop on Achieving in Situ Functional Histology, IIT Kharagpur, 21-22 March 2015. Resource Persons 6. Binukumar B. Workshop on Research Methodology in 1. Aravind Raj E (i) Disaster Psychosocial Intervention, 21- Psychosocial issues organized by Department of Psychiatric 25 April 2014 (ii) National Level Refresher Training of Key Social Works, NIMHANS, 24-26 November 2014 (ii) Resource Persons of State Resource Centers on Disaster Workshop on Research Methodology organized by Department Management, 24 July 2014 (iii) Samprathi 2014- UGC of Epidemiology, NIMHANS, 10-12 December 2014. sponsored National Seminar on People’s Participation in Disaster Prevention and Management,17 September 2014 (iv) 7. Chaturvedi SK. Seminar on Major Depressive Disorders Long (a) One week Transplant Coordinator Training Program, 02 Term Outcome, Lundbeck Institute Singapore, 7-8 June 2014. December 2014(b) Training Programme on Community Based Disaster Risk Management,03 December 2014 (v) Gender and 8. Dhananjaya I Bhat. 6th NSI Teaching Course organized by Disaster, 22 January 2015 (vi) Gender and disaster, NIDM, Dept.of Neurosurgery, SGPGI, Lucknow, August 2014. New Delhi, 18 March 2015. 9. Dhanasekara Pandian R (i) Workshop on Stress Management 2. Aravind Raj E, Kavita Jangam. State level Training for Child for Pollution Control Department Officials at Bangalore, 7 Line Teams on Prevention and Response to Child Sexual April 2014 (ii)Key Note Speaker-15th Year Foundation Day Abuse- Emotional, Medical and Legal Aspects, 21 June 2014. Celebration of CARE Foundation, Bangalore, 01 May 2014 (iii) Stress management Workshop for Government Officials 3. Aravind Raj E, Sekar K (i) CBHI Training–Orientation of Karnataka, State Training Institute, Bangalore,22 November course on Family of International Classification for MRD 2014, 13 January 2015, 5 February 2015, 25 February 2015,9 Personnel (ICD–10 & ICF), 20 June 2014 (ii) Workshop March 2015 (iv) One day Workshop organized by Regional on Psychotherapy Practice in Medical and Psychiatric Social Office for Health and Family Welfare, Bangalore, Sanjay Work Setting, 01 August 2014 (iii) CBHI training–Inservice Gandhi Institute of Orthopedics, Bangalore, 24 February 2015. Training on FIC (ICD10 & ICF),08 August 2014 (iv) TOT Workshop on Family of International Classification (ICD 10 10. Dhanasekara Pandian R, Soyus John (i) Training Programme & ICF), 21 August 2014 (v) State Level Workshop on Disaster on Tobacco Related Problems and Interventions. Centre for Management,19 September 2014 (vi) National Workshop on Addiction Medicine, NIMHANS, Bangalore, 22 July 2014 (ii) Research Methodology in Psychosocial Issues, 24 November Addiction Prevention among the ITI students through their 2014 (vii) Two Day Mental Health Enrichment Training for Teachers, 08, 15, 29 October 2014. Community Differently abled Welfare Facilitators of Pudhu Vaazhvhu Project, Govt of Tamil Nadu, 5 September 2014, 18 11. Gope R. (i) Human brain tumors (ii) Effect of small molecules September 2014,18 November 2014,15 December 2014, 22 on the post translational modification of p53 protein in human December 2014,17 March 2015, 24 March 2015 (viii) One day VS tumors. Refresher course for University and College teachers Workshop organized by Regional office for Health and Family in the discipline of Biotechnology, Microbial Biotechnology Welfare, Bangalore, Baptist Hospital, Bangalore, 6 March and Bioinformatics. Academic Staff College of Bharthiyar 2015. University, Coimbatore, 11 November 2014.
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12. Hirisave U. Brainstorming Workshop on Health Promoting Arvinth College of Nursing, Namakkal, 29-30 April 2014 (ii) School Program, He Psy Nsg, Jawahar Navodaya Vidyalaya, St Post traumatic stress disorder & acute stress disorder. 14th John’s Research Institute, Bangalore, 27-28 November 2014 (ii) Annual National Conference of ISPN: Mental Health Nursing Child development theories relevant for interventions, Training perspective in Emergency Care, Ahmedabad, 31 January-2 of Trainers Programs, Child Protection Personnel of Karnataka, February 2015. Bangalore, 2 April 2014 (iii) Project on Setting up a School for Children with Disabilities at the District level by Jindal Steel 15. Karthikeyan. Sports injury evaluation and treatment strategy. Plant, Bangalore, 25 May 2014. 3rd International Conference, AIIMS, New Delhi, 18-21 December 2014. 13. Janardhana N (i) Psychosocial care for children in difficult circumstances,14 April 2014 (ii) Counselling Adolescents at 16. Kavita Jangam (i) Psychotherapy practice in medical and the UGC Sponsored Symposium and Workshop Psychological psychiatric social work settings organized by Dept of PSW, Issues and Challenges related to Women and Children’ NIMHANS, 31 July 2014 (ii) Safety measures to be in place. organized by Maharani Women’s College, Bangalore (iii) The IAS Officers Wives Association & DWCD Bangalore, (a) Stress management for parents caring speech and hearing 02 October 2014 (iii) Peer learning and communication impaired children (b) Stress management for speech and skills. Workshop on Life Skills for Teachers organized by hearing impaired adolescents girls, 23 May 2014 (c) CBR Dept of Psychiatry, NIMHANS, 10 October 2014 (iv) Types and mental illness, 22 June 2014, 15 January 2015 (iv) Stress of Counseling in training on Counseling Skills for Teachers management for the executives of Hyundai Factory, 04 July of Govt ITI, 14 October 2014 (v) Consultative Meeting on 2014 (v) Effective Parenting Workshop, 19 July 2014 (vi) Promoting Right to Play, International Play Association- Panelist for qualitative research questions in Psychiatric Social India in association with Headstreams, Bangalore, 15 October Work Research, 02 September 2014 (vii) Early intervention for 2014 (vi) Empowering women students and faculty in the children with intellectual disability for RBSK, 05 September context of increasing violence against women. St. Claret 2014 (viii) Understanding children and counseling skills for College, Bangalore, 21 October 2014 (iii) Peer learning and the CWC and JJB Members Counselors organized by the communication skills. Workshop on Life Skills for Teachers Department of Psychiatric Social Work, 8, 22 September 2014; organized by Dept of Psychiatry, NIMHANS, 14 March 2015. 14, 27 October 2014; 3, 14 November 2014; 6 December 2014 (ix) Sensitization about the Child sexual abuse among the 17. Krishna Reddy N. Psychotherapy Practice in Medical and school children ,08 September 2014,26,27 September 2014 (x) Psychiatric Settings, 02 August 2014 (ii) Practitioners Social Stress management and problem solving: Dealing with child, 12 Workers Meet 2014, 11 August 2014. September 2014; 18, 31 October 2014; 6, 14 November 2014; 6 December 2014 (xi) Substance abuse among adolescents at 18. Kumar R. Perspective on neuropsychology. Department of UGC sponsored Symposium and Workshop on Life Skills Psychology, PSG College of Arts & Science, Coimbatore, Counseling organized by National Degree College, Jayanagar, Tamil Nadu, 12 February 2015. Bangalore, 17 September 2014 (xii) Understanding domestic violence, 29 October 2014 (xiii) Mental health problems among 19. Lalitha K. Impact of scientific innovations in human life. people with disabilities seeking prosthetic and orthotic services, International Conference, Psychosocial Perspectives- Patient 14 November 2014 (xiv) Identification of child sexual abuse in Perception on Technological Advances, Sree Balaji College schools, 20, 29 November 2014 (xv) Childhood behavioural of Nursing, Chennai, 28 November 2014 (ii) Workshop on problems and psychosocial management role of Psychiatric Inculcating Quality in Nursing, Maruti College of Nursing, social work, 27 December 2014 (xvi) Behavioural and mental Bengaluru, Upgrading Quality in Nursing Research, 3 health problems in children: role of counseling, 22 January April 2014 (iii) 2nd State Level Conference on Nursing 2015 (xvii) Need for life education for adolescents, 9 February Research-Mixed Methods Research- Third Methodology, 2015 (xviii) Child development and psycho social needs for Application of MMR in Nursing– A glance at mixed research community workers, 16 February 2015 (xix) Understanding method through some examples, Govt. College of Nursing, children and need for child protection, 16 February 2015 (xx) Alappuzha, Kerala, 9 May 2014 (iv)One Day National Identification of Child sexual abuse in schools, Childhood Conference on ‘Scholarly Writing for Research Publication mental health problems. in Nursing’, RVS College of Nursing, Coimbatore, Writing Research Publication in Nursing, 11.7.2014 (v) Effective 14. Jayanthi KN. Psychiatric emergencies. National Workshop on Mentor-Mentee Communication, One Day Workshop on Newer Perceptions in Disaster & Emergency Managements, Successful Mentoring in Nursing, funded by Dr. R.N Moorthy
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Foundation for Mental Health and Neurological Sciences, Rajahmundry, A.P., 13 March 2015 (xv) Nursing care plan, College of Nursing, NIMHANS, Bengaluru, 19 July 2014 (vi) National Conference A step to promote professional practice Psychiatric Emergencies, 1st National Conference on Trends in nursing, Institute of Nursing Education, School of Medical in Nursing Care Management, School of Nursing, Karaikal Education, MG University, Regional Centre, Pathanamthitta, Branch, Mother Theresa Post Graduate and Research Institute Kerala, 14 March 2015 (xvi) Concept of Care Giver Burden, One of Health Science, Puducherry, 15 September 2014(vii) Mark day Workshop on Interventions to address Care Giver Burden, a new trial in substance abuse and Panel Discussion on Needs Dept. of Nursing, NIMHANS, Bengaluru, 17 March 2015. of independent nurse practitioner. National Conference on Empower Nursing: Reflecting on Challenges and Changes, 20. Malla Bhaskara Rao. Epilepsy Surgery. Muller PsyCon JSS College of Nursing, Mysore, 30 September 2014 (vii) 2014 Conference, Mangalore, 20 July 2014 (ii) Uncontrolled Seminar on Intervening with Tobacco Uses: Role of Nursing Epilepsy. Performed Demonstration Epilepsy. Guwahati, 25-26 Professionals, Burden of tobacco use–global and regional, March 2015. NIMHANS, Bengaluru, 8 October 2014 (vii) (a) Comparison between qualitative and quantitative research (b) Theory 21. Manjula M. Cognitive behavioural interventions in anxiety building in qualitative research (from reality to theory). disorders and depression- Symposium on CBT in Anxiety Qualitative Research: A step towards theory construction Disorders. International Conference on Cognitive Behavioural and development, NRSICON 2014, 18th Annual National Interventions, AIIMS, New Delhi, 2-3 March 2015. Conference Society of India, Choithram College of Nursing, Indore, M.P, 14-15 November 2014 Delivered Key Note 22. Mythili D. National Workshop on Innovative teaching address (viii) Two-day Mental Health Enrichment Training techniques in psychiatric nursing, NIMHANS, Bangalore, 26 for Community Differently abled Welfare Facilitators Pudhu November 2014. Vaazhvu Project (TNPVP) run by Panchayat Raj and Rural Development under the Govt. of Tamil Nadu, Dept. of 23. Phalguni Anand Alladi. TS Srinivasan NIMHANS Knowledge Psychiatric Social Work, NIMHANS, Bengaluru, Introduction Conclave 2015-Autonomic Dysfunction an Interdisciplinary to Mental Health and Positive Mental Health Practices, 3 Workshop for Clinicians and Scientists, NIMHANS, September 2014, 17 September 2014; 17 November 2014; 15, Bangalore, 12-13 February 2015. 22, 29 December 2014, 29 January 2015; 4,5 February 2015; 11, 12, 22, 26 February 2015; 17, 23 March 2015 (x) Teaching 24. Poornima Bhola, Chethan Basavarajappa, Ananya Sinha. and learning in psychiatric nursing– a paradigm shift, One Day Clinical skills Workshop on Social Skills Training and Social Workshop on Innovative Teaching Techniques in Psychiatric Cognition Remediation. Psychiatry Update 2014: Clinical Nursing for Nursing Students and Teachers, College of skills Workshop on Cognitive Assessment and Remediation, Nursing, NIMHANS, Bengaluru, 26 November 2014 (xi) Manipal, Karnataka, 15-16 November 2014. Experimental designs used in nursing research. National Conference on Data Analysis and Management in Nursing 25. Prashanthi Nattala (i) Therapies in mental disorders Research, Shri B.V.S Sajjalashree Institute of Nursing Sciences, Induction/Refresher Class for Newly Recruited Staff Nurses, Bagalkot, 4 December 2014 (xii) Plenary Session III–Domain NIMHANS, Bangalore, 18 June 2014 (ii) Frameworks and competencies in mental health nursing, National Conference on guidelines for enabling systematic mentoring in nursing. Competency Based Education and Practice, Sinhgad College One Day Workshop on Successful Mentoring in Nursing, of Nursing, Pune, 20 December 2014 (xiii) Research utilization Department of Nursing, NIMHANS, Bangalore, 19 July versus EBP in nursing, One Day Workshop on Evidence Based 2014 (iii) Physical and mental health: interdependence, Practice in Nursing funded by Dr. R.N Moorthy Foundation implications for overall health. Workshop on Care of the for Mental Health and Neurological Sciences, College of Body, Baduku Community College, Samvada Counseling Nursing, NIMHANS, Bengaluru, 12 January 2015 (xiii)One Centre, Bangalore, 26 September 2014 (iv) Evidence based Day Workshop on Childhood Behavioural Disorders and its learning–an innovation from a psychiatric nursing perspective, Management: A Multidisciplinary Approach, An overview Workshop on Innovative Teaching Techniques in Psychiatric on Childhood Behavioural Disorders, College of Nursing, Nursing, Department of Nursing, NIMHANS, Bangalore, 26 NIMHANS, Bengaluru, 22 January 2015 (xiv) Nature and November 2014 (v) Models in evidence based practice and design of mixed methods research. National Conference, application to nursing. Workshop on Evidence Based Practice Theme: Mixed Methods Research–An Innovative Approach in Nursing, Department of Nursing, NIMHANS, Bangalore, to Nursing Practice, Swatantra /GSL Colleges of Nursing, 12 January 2015.
302 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
26. Pratibha Swamy. Core competences & skills of nurses in 32. Reeta Mani. Hands on Training Workshop on DNA PCR, at fluid management in heart failure. National Conference on SDM College of Medical Sciences & Hospital, Dharwad, 19- Transforming Health Care. A Pathway to Excellence in Nursing, 21 February 2015. KLE’s College of Nursing, Belgaum, 8-9 September 2014. 33. Roopesh BN (i) Behavioral interventions. Capacity Building 27. Priya Baby. Neuro and hemodynamic monitors. National and Counseling Training for the Child Protection Workshop, Workshop, JSS college of Nursing, Mysore, 25 February 2015. Bengaluru, 25 April 2014 (ii) Scope of clinical psychology. M.Sc. & B.Sc Students of Central University of Karnataka, 28. Raguram. A Family dynamics: impact on personality Bengaluru, 16 July 2014 (iii) Student Psychology; counseling for development. National Seminar on Family Dynamics students, BMS Engineering College, Bengaluru, 5 August 2014 and Religious Life: Challenges, Issues and Implications, (iv) Mental health. Health Course Training, Mount Carmel Dharmaram Vidya Kshetram, Bangalore, 9 August 2014 College, Bengaluru, 21 August 2014 (v) Mid-adolescence issues (ii) Psychotherapy and counseling in the Indian context. and concerns; Late-adolescence issues and concerns. Parents Workshop on Psychotherapy and Counseling in Medical and and Teachers meet, Bramhavar, 30 August 2014 (vi) (a) Case Psychiatric Social Work settings, Dept of Psychiatric Social history schedules. 2 September 2014 (b) Administration and Work, NIMHANS, Bangalore, 31 July 2014. Scoring of Vineland Social Maturity Scale, 8 September 2014 (c) Binet–Kamat Test–Administration, Scoring and Report 29. Rajeswaran J. (i) Cognitive functions in mTBI and EEG writing, 10 September 2014 (d) Attention deficit hyperactivity Neurofeedback Training at the National Neurotrauma Society disorder–An overview; Behavioral Management of Attention of India. Mussorie, Uttarakhand 29-31 August 2014 (ii) EEG Deficit Hyperactivity Disorder, 23 September 2014, Rastriya Neurofeedback training at BRAIN GROUP, Christ University, Bal Swasthya Kendra–District Early Intervention Program Bangalore, 23 August 2014 (iii) International Symposium on Training, Bengaluru (vii) Theories of Child Development. Translational Neuroscience and 32nd Annual Conference of Capacity Building and Counseling Training for the Child the Indian Academy of Neuroscience 1-3 November 2014, to Protection Workshop, Bengaluru, 15 September 2014 (viii) function as Panel Discussant in Popularizations of Neuroscience, Late adolescence-issues and concerns; Mid adolescence-issues NIMHANS, 3 November 2014 (iv) Brain-storming meeting and concerns. Interactive Program, Padma Sheshadri Bal on consciousness, cognition and culture: implications for the Bhavan, Bengaluru, 16 October 2014 (ix) Neuropsychological 21st Century, on brain sciences, phenomenology and creativity. assessment. Continuing Medical Education, KMC, Manipal, National Institute of Advanced Sciences, IISc Campus, 15 November 2014 (x) Neuropsychological rehabilitation. Bangalore, 11-12 December 2014. Continuing Medical Education, KMC, Manipal, 15 November 2014 (xi) Stress management and study skills. Interactive 30. Rajeswari C. National Conference on Transforming Nursing Program for Marasooru Government School Students, Research– A view to enhance practice Karur, Tamil Nadu, 11 Bengaluru, 20 November 2014 (xii) Overview of childhood March 2015. mental disorders–Attention deficit hyperactivity disorder, Autism spectrum disorders, and Specific learning disorders. 31. Ramachandra (i) One Day Workshop on Successful Mentoring Interactive Program, Department of Psychology, Christ in Nursing, NIMHANS, Dept. of Nursing, Bangalore University, Bengaluru, 21 November 2014 (xiii) Interpreting (a) Overview of Mentorship and stages of mentorship.(b) psychological tests results in SPSS. Interactive Workshop at Strategies to evaluate the effectiveness of mentoring student Department of Psychology, Maharani College, Bengaluru, nurses, 19.7.2014 (ii) One Day Workshop on ‘Evidence Based 13 December 2014 (xiv) Depression and suicide prevention. Practice in Nursing’, NIMHANS, Dept. of Nursing, Bangalore, Interactive Program for Ninth Standard students, Bangalore Evidence Based Practice: Significance in Nursing, 12.1.2015 High School, Bengaluru, 29 December 2014 (xv) Depression (iii)Workshop on Role of Schools in the management of and suicide prevention. Interactive Program for Tenth Standard Childhood Behavioural Disorders, College of Nursing, Students, Bangalore High School, Bengaluru, 30 December NIMHANS, Bangalore, Childhood behavioral disorders and 2014. its management: A multidisciplinary approach, 22 January 2015 (iii)Silver Jubilee Year Conference on Evidence Informed 34. Sailaxmi Gandhi S (i) An Experimental Workshop for Nurse Practice: An approach to Health Care Reform, Manipal Educators on Qualitative Research Approach in Nursing, College of Nursing, Manipal, Evidence Informed Health Organised by the Department of Nursing Education, RGUHS, Care: Strategies to overcome challenges and constraints, 24-25 in collaboration with St. John’s College of Nursing, Bangalore, January 2015. Research question in qualitative approach: Phenomenology
National Institute of Mental Health and Neuro Sciences 303| Annual Report 2014-15
Grounded Theory &Ethnography, 24 April 2014 (ii) 35. Sathishchandra P. Human brain–an enigma. Science camp Demonstration of mental status examination, In-Service sponsored by the Department of Science and Technology Education Programme for the Staff Nurses, Department of (DST), Government of India, INSPIRE Program, Shree Nursing, NIMHANS, Bangalore, 21 June 2014 (iii) Mentoring Siddaganga College of Arts, Science and Commerce for student nurses in the changing health care context. One Day Women, Tumkur, 26 December 2014. Workshop on Successful mentoring in nursing, Department of Nursing, NIMHANS, Bengaluru, 19 July 2014 (iv) Evidence 36. Satyanarayana VA. Counselling victims of trauma in ACT: based research findings in mental health nursing. National Awareness for counselors about trauma-A Workshop on Conference on Global Trends in Evidence Based Nursing Psychological Trauma organized at the NIMHANS Centre for Practice– A key Excellence in Health Care, SRM College of Wellbeing, Bangalore, 3 September 2014 (ii) Critical incident Nursing, Chennai, 23 July 2014 (v) Hazards of tobacco use– stress debriefing in CARE: Crisis Alleviation and Recovery health, occupational, economic. Workshop on Intervening with from Emergencies. Workshop on Crisis Counseling organized Tobacco Users: Role of Nursing Professionals, Department of at NIMHANS Centre for Wellbeing, Bangalore, 12 November Nursing, NIMHANS, Bangalore, 8 October 2014 (vi) Advanced 2014 (iii) Trauma informed care & counseling in SCARS: methodology in mixed method research in nursing. 1st Securing Courage and Resilience for the Sheltered: A Trauma- National Nursing Ph.D Society Conference, Sri Ramachandra Informed Care Workshop for Counselors in Shelter Homes University, Chennai, 28 October 2014 (vii) Research in caring organized at NIMHANS Centre for Wellbeing, Bangalore, 7 in nursing, National Conference on Epitome of Nursing: January 2015 (iv)Preventing counselor impairment in STAR: CARING, Arulmigu Meenakshi College of Nursing, Secondary Trauma Alleviation and Recovery. Workshop on Kancheepuram, 29 October 2014 (viii) Problem based learning Counselor Wellness organized at the NIMHANS Centre for Workshop on Innovative teaching techniques in Psychiatric Wellbeing, Bangalore, 11 March 2015 (v) Research ethics. Nursing, Department of Nursing, NIMHANS, Bangalore, Workshop on Research Methodology-2014, jointly organized 26 November 2014 (ix) Recovery oriented services: success by the Departments of Biostatics, Epidemiology, Psychiatry stories and lessons learnt, Symposium, ANCIPS, Hyderabad, and Neurology, Bangalore, 10-12 December 2014 (vi) Panel 8-11 January 2015 (x) Resources to facilitate EBP in nursing. Discussion on Research questions qualitative research approach One Day Workshop on Evidence Based Practice in Nursing, can address” in a Workshop on Integrating Qualitative & Department of Nursing, NIMHANS, Bengaluru,12 January Quantitative Research Methods Fundamentals and Innovative 2015 (xi) Legal issues in the care and management of children Strategies jointly organized by the Departments of Health with mental health problems, One Day Workshop on Child Education, Bangalore, 2-4 September 2014. Behavioral Disorders & its Management–A multidisciplinary approach, Department of Nursing, NIMHANS, Bengaluru, 37. Seema N. Emotion regulation through counteractive 22 January 2015 (xii) Importance & goals in rehabilitation, responding’. Workshop on Emotion Regulation for healthy Workshop on Update about Recovery Oriented Services Living. NIMHANS Centre for Well Being, Bangalore, 21 June (ROSes), Psychiatric Rehabilitation Services, Department 2014 (ii) Finding values and reorganising life: Workshop on of Nursing, NIMHANS, Bangalore, 31 January 2015 (xiii) Know your Feelings, Handle them Better. Belgaum, Karnataka, Research Methodology, LGB Regional Institute of Mental 29 January 2014 (iii) Handling difficult issues: Workshop on Health, Tezpur, Assam, Series of Lecture, 4-6 March 2015 (xiv) Parenting Teenagers Emotion Regulation for Healthy Living. Psychosocial rehabilitation, Seminar on Psychiatric Nursing, NCWB, Bangalore, 5 July 2014 (iv) Time management: Department of Nursing, NIMHANS, Bengaluru, 11 March Workshop on Academic Stress Management. NCWB, 2015 (xv) Guidelines for volunteers & services offered at PRS. Bangalore, 20 September 2014. Volunteer Sensitization Program, Psychiatric Rehabilitation Services, NIMHANS, Bangalore, 24 March 2015 (xvi) Role 38. Sekar K (i) Training on Psychosocial Care for School Teachers. of nurses as researcher in community mental health nursing, Organised by Municipal Corporation, Shimla, UNDP DRR in One Day Workshop on Community Mental Health Nursing, 7 Cities. Himachal Pradesh, 12-13 November 2014 (ii) Session Department of Nursing, NIMHANS, Bangalore, 31 March on (a) Life Skills Education (b) Counsellors code of ethics. 2015 (xvii) Burden Reduction Strategies, One Day Workshop ICSSR sponsored National Workshop on Psycho-Educational on Interventions to address caregiver burden for family member, Skills for Teachers of Higher Education. Organised by Psychiatric Special Ward, Block ‘C’, NIMHANS, Bengaluru, Department of Social Work, Bharathidasan University, 17 March 2015. Tiruchirapally, 29 October 2014 (iii) Stigma and pathways to
304 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
mental health care and illness identification in the community 44. Suman LN. Psychological standards for determining the best and rehabilitation services. Mental Health Enrichment interests of the child. National Conference of the Presiding Training for Community Differently Abled Welfare Officers of Family Courts, National Judicial Academy, Bhopal, Facilitators. Puthuvaazhu Project, Government of Tamil Nadu, 25 July 2014 (ii) Introduction to psychological trauma. 5 November 2014 (iv) (a)National Training Programme on Workshop on Psychological Trauma: ACT: Awareness for Counselling for Street Educators on Ethics for Counsellors, 29 Counselors about Trauma, NCWB, 3 September 2014 (iii) October 2014 (b) Workshop on Psycho Education Skills for Crisis assessment. Workshop on Crisis Counseling: CARE: College Teachers on Role of College Teachers in Counselling, Crisis Alleviation and Recovery from Emergencies, NCWB, 29 November 2014. ICSSR sponsored National Workshop on 12 November 2014 (iv) Psychological trauma among women Psycho-Educational Skills for Teachers of Higher Education in shelter homes. Workshop on Trauma-Informed Care for (v) Workshop on Psycho Education Skills for College Teachers Counselors in Shelter Homes: SCARS: Securing Courage and on Role of College Teachers in Counselling. Organised by Resilience for the Sheltered, NCWB, 7 January 2015 (v) Self- District Administration, Government of Tamil Nadu, and regulation for maintaining recovery. R.N.Moorthy Foundation Sangam Madurai, 29 November 2014 (vi) National Training funded Regional Workshop on Relapse Prevention in Alcohol Programme on Counselling for Street Educators on Ethics Dependence, NCWB, 28 January 2015 (vi) Secondary trauma. for Counsellors. Organised by Madurai Institute of Social Workshop on Counselor Wellness: STAR: Secondary Trauma Sciences and sponsored by National Institute of Social Defence, Alleviation and Recovery, NCWB, 11 March 2015. Government of India. Madurai, 29 November 2014. 45. Suresh Parmar. Neuroanatomy and basic neurophysiology 39. Senthil A. Situation analysis in Kolar district & challenges in training for 7th National Brain Bee Championship participants. convergence. Workshop on Early Intervention & Rehabilitation Sevenhills Hospitals, Marole, Andheri (E) Mumbai, 19-20 for Children with Intellectual & Developmental Disabilities. April 2014 (ii)Weeklong Anatomy and Kinesiology (Basic Jointly organized by Seva-in-Action, SNAC-Karnataka & Regional) Training to the Trainees. Hatha Yoga Teacher of National Trust in collaboration with Dept of Child & Training Course, Mystic Yoga School, Mysore, 2-7 March Adolescent Psychiatry & Speech Pathology & Audiology, 2015. NIMHANS & State Health Department, Bengaluru, 23-24 January 2015. 46. Thirumoorthy A (i) Workshop on Recent Trends in Psychiatric Social Work. Recent trends in Adult Psychiatric Settings. 26 40. Siddharth D. Assessment of intelligence–practice sessions. June 2014 (ii) (a) Workshop on Recent Trends in Psychiatric RBSK Training Program, NIMHANS, Bangalore, 20 Social Work (b) Workshop on Psychotherapy Practice in September 2014. Medical and Psychiatric Social Work Settings, 01 August 2014 (iii) Workshop on Counseling Skills for Teachers of Govt. 41. Snigdhasree B, Anupama V, Hirisave U. Adolescent sex Industrial Training Institute, Bangalore,14 October 2014. education, Titan School, Hosur, 28 January 2015. 47. Valliammal S. (i) (a) Reaching the heights in nursing 42. Snigdhasree B, Hirisave U (i) (a) Assessment of intellectual administration, 9 July 2014 (b) Incessant grandeur of education, functions. 11 September 2014 (b) Assessment of intellectual National Conference, Adhiparaskthi College of nursing, learning disability, 20 September 2014 (c) Assessment of Melmaruvathur, 12 November 2014. readiness skills, 16 September 2014, RBSK Training program, NIMHANS, Bangalore (ii) Management of school refusal. 48. Vidhyasagar K (i) Maintaining healthy relationships. Workshop Prasanna Counseling Centre, Bangalore, 24 January 2015. for Youth. NCWB, NIMHANS, Bangalore, 26 April 2014 (ii) Workshop on Emotion Regulation for Healthy Living. NCWB, 43. Sudhir PM. (i) Session on Social Skills: Methods and Principles, NIMHANS, Bangalore, 21 June 2014 (iii) Maintaining Healthy Workshop on Social Skills Training for Schizophrenia, Parent Teenager/Young Adult Relationships: A Workshop for NIMHANS, 21 February 2015 (ii)Session on Managing Parents and Youth. NCWB, NIMHANS, Bangalore, 5 July and regulating emotions at workplace: Cognitive behavioural 2014 (iv) Workshop on Cognitive Behaviour Therapy in Sexual and mindfulness approaches,Supporting Mental Wellness of Dysfunctions. Department of Clinical Psychology, NIMHANS, Employees :An Orientation-Sensitization Workshop, Unilever, 25-26 July 2014(v) Being in the present moment: De- Bangalore, 15-16 April 2014. stressing mindfully. Workshop on Workplace Stress. NCWB,
National Institute of Mental Health and Neuro Sciences 305| Annual Report 2014-15
NIMHANS, 23 August 2014 (vi) Workshop on Cognitive Association-Bangalore Chapter Conference on Audio- Behaviour Therapy: Principles and Applications. Department Video Methods- from Recording to Analysis, Application in of Clinical Psychology, NIMHANS, 30-31 October 2014 Diagnosis and Intervention in Speech Language Pathology (vii) Mindfulness–Based Cognitive Behavioural Interventions: and Audiology, NIMHANS, Bangalore, 11-12 October 2014 Applications in Clinical and Nonclinical Settings. Department (v) Dysphagia management-thermal stimulation. Seminar on of Clinical Psychology, NIMHANS, 21-22 November 2014 Basics and Insights for Speech Language Pathologists. Dr. S.R. (viii) Maintaining Healthy Relationships: a Workshop for Chandrashekar Institute of Speech and Hearing, Bangalore, 28 Youth. NCWB, NIMHANS, 6 December 2014 (ix) Know your February 2015. feelings, Handle them better. Lingaraj College, Belgaum, 29 January 2015 (x) Workshop on Cognitive Behaviour Therapy for Obsessive Compulsive Disorders. Department of Clinical Radio/Tv/Phone-in Programmes Psychology, NIMHANS, 23- 24 January 2015 (xi) Managing academic stress. SSMRV College, Bangalore, 19 March 2015. 1. Chaturvedi SK. Communication with cancer patients: Consumers & care providers perspectives, Psycho Oncology 49. Vinayak K. Workshop on Intellectual Disability, Cerebral Research & Training, PORT Seminar, McGill University, Palsy and Autism for volunteers, organized by Sarva Siksha Students from 5 universities in Quebec, Canada, Video Abhiyan, Kolar District in collaboration with Dept. of Child & conferencing, 10 April 2014. Adolescent Psychiatry, Dept. of Speech Pathology &Audiology and Dept. of Epidemiology, NIMHANS, Bengaluru, 25 March 2. Chetan GK. Is super human possible? Advances in Science, 2015. BTV News channel, 26 September 2014.
50. Vranda MN (i) Life skills education for counselors. organized 3. Dhanasekara Pandian R. Treatment and Rehabilitation services by Samadhana Counseling Centre, Bangalore,03 April 2014 for addiction Problems, Manochinthana, All India Radio, 9 (ii) Suicide prevention for health assistant. Indian Air Force, January 2015. Bangalore,11, 18 June 2014 (iii) Workshop on Psychotherapy Practice in Medical and Psychiatric Social Work Settings, 4. Jamuna Rajeswaran, Divya Sadana. The Times of India, organized by the Department of Psychiatric Social Work, Creativity flows from the left brain too, Print, 24 November NIMHANS, Bangalore, 31 July 2014 (iv) Tools and assessment 2014, techniques used in life skills counseling, UGC sponsored Symposium and Workshop on Life Skills Counseling 5. Janardhana N. CBR and mental illness, Manochintana, All organized by National Degree College, Jayanagar, Bangalore,17 India Radio. September 2014 (v) Management of Autism–Workshop for Counselors of NGO’s, Department of Psychiatric Social Work, 6. Krishna Reddy N. Mental Health, Manochintana, All India NIMHANS, Bangalore,15 October 2014 (vi) Life Skills for Radio, 20 June 2014. Government Employees, District Training Institute, Bangalore, 19 November14 (vii) Scale construction in psychosocial issues, 7. Manjula M (i) Hadiharayadavara Manasika Arogya National Workshop on Research Methodology in Psychosocial Manochinthana, Vividhabharathi program, Akashavani, 19 Issues organized at Department of Psychiatric Social Work, December 2014. NIMHANS, Bangalore, 24 November 2014. 8. Manoj K Sharma. (i) Children and cyber attack , interview, Zee 51. Yamini BK (i) (a)Clinical correlates of hyperkinetic and News, 1 June 2014 (ii) Technology addiction, interview, News hypokinetic dysarthria: Illustrative case studies (b) Clinical Nation TV Channel, 2 June 2014 (iii) Technology addiction/ correlates of ataxic and mixed dysarthria: National Seminar SHUT Clinic, interview, CNN IBN, 5 June 2014 (iv) First on Assessment of Neurogenic Communication Disorders; technology addiction clinic, interview, Aajtak/Headlines Today, Illustrative case studies. Dr. S.R. Chandrasekhar Institute of 7 June 2014 (v) Tech De-addiction Clinic, interview, NDTV, 10 Speech and Hearing, Bangalore, 21-23 August 2014 (iii) The June 2014 (vi) Indians losing lifestyle to technology use, DNA electromagnetic articulograph: from installation to application. Newspaper, Mumbai, 11 June 2014 (vii) NIMHANS initiative– 4th Tamil Nadu ISHAcon 2014, Yercaud, Tamilnadu, 19-21 tech Deaddiction Clinic, The Telgraph, Kolkata, 22 June 2014 September 2014 (iv) (a)Application in aphasia and dysarthria (viii) Psychological help to manage psychological problems. (b) Normal development of language– Six months to four Deccan Chronicle, 19 June 2014 (ix) Helping web junkies out of years plus: A Language Movie. Indian Speech and Hearing tech addiction–India first deaddiction center, The Times of India,
306 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
22 June 2014 (x) Tech Deaddiction Clinic in India, Radio, BBC 13. Pratima Murthy. Drug de-addiction awareness, Hello Geleyare (Hindi), 23 June 2014 (xi) Tech Deaddiction Clinic in India, Live programme, Doordarshan Kendra, 23 June 2014 (ii) Radio, BBC (Tamil), 24 June 2014 (xii) Service for management Tobacco as a Gateway drug, Press Conference (Electronic and of technology addiction, Kochi Times, 27 June 2014 (xiii) Print Media) organized by IPHI on Anti-Drug Day, 25 June Hooked to the Handset, India Today, 28 July 2014 (xiv) Beware, 2014, (iii) Drug Abuse and its Consequences, Press Conference You cyber addict, The Week, September 2014 (xiv) Is your child (Electronic and Print Media) organized by IPHI on the Eve of addicted to technology, Rajasthan Patrika, 23 November 2014 World Heart Day, 27 September 2014. (xvi) Existence in virtual shadows, News Bench, November 2014 (xviii) First support group for tech addicts at NIMHANS 14. Rajakumari PK, Jamuna Rajeswaran. Why some people are deaddiction clinic, Bangalore Mirror, 7 January 2015 (xix) compassionate, The Week magazine (print), 16 November NIMHANS decodes why collegians speed, Bangalore Mirror, 13 2014. January 2015 (xx) Whatsapp keeping Indian teen wake at night, The Times of India, 20 July 2014 (xxi) Addiction to technology 15. Ravikumar R. Anti microbial resistance – A road map to tackle is increasing in the city, Deccan Herald, 24 February 2015 (xxii) challenges, Video Conference, 23 December 2014 (ii) World Technology addiction: Concern of health for Bangaloreans, The TB Day, Video Interview, 20 January 2015. Times of India, 10 March 2015. 16. Seema Mehrotra. Mental health and road safety: Reach out the 9. Nagarathna S. Typhoid, All India Radio, Prasara Bharati, 14 youth, May 2014, Internet (ii) Suicide prevention: Voices of December 2014 (ii) Hepatitis A, All India Radio, Prasara hope and single step, September 2014, Internet. Bharati, 24 December 2014 (iii) Leptospirosis, All India Radio, Prasara Bharati, 4 January 2015 (iv) Importance of cleanliness, 17. Shivashankar N. Auditory Behavior Development, Auditory All India Radio, Prasara Bharati, 14 January 2015. System, Impact of Hearing Loss in Children, Role of Parents in Speech Language Development. Radio Doctor, AIR, 30 10. Naveen Kumar C. Suicides, Manochintana, Radio, 7 July January 2015. 2014 (ii) Psychiatric Rehabilitation, Manochintana, Radio, 29 August 2014. 18. Srinivas Bharath MM. What Happens in a Brain Bank: A Question of Science, Doordarshan-National (DD-1), 14 May 11. Poornima Bhola. (i) Suicide prevention: A conversation can save 2014 (ii) Brain Bank and Brain Donation, Morning with a life, White Swan Foundation website (ii) Savina Suliyinda Murali (Daily TV programme), Suvarna Channel-Kannada, 12 Seleyuvudhu Hege (Suicide Prevention), Prajavani, 13 September December 2014. 2014 (iii) Self-injurious behavior among youth, Bangalore Mirror, 20 July 2014. 19. Urvakhsh M Mehta. Boosting Social Cognition in Schizophrenia, Report on the 15th International Congress 12. Prabha S. Chandra. Suicide prevention amoung youth, White on Schizophrenia Research, Schizophrenia Research Forum Swan Foundation website. Website, 11 April 2015.
National Institute of Mental Health and Neuro Sciences 307| Public Lectures
Child & Adolescent Psychiatry of Rotary Club (ii) Traditional medicine and Parkinson’s disease: Researchers’ quest, Guest lecture, Rotary Club Indiranagar, Bangalore, Dr. Girimaji SC, Professor and Head, Behavior problems in school 16 February 2015. Target group: Members of Rotary Club. children, World Mental Health Day celebrations, Kolar, 10 October 2014. Target group: Teachers Neurology
Clinical Psychology Dr. SR Chandra, Professor, talk on Approach to neurodegenerative disorders in children, Vatsalyam, Neyyoor, Kanyakumari, 2 March 2014. Dr. Sudhir PM, Additional Professor, (i) Stress and Anger (orientation Dr. S Sinha, Additional Professor, Epilepsy YES-BEEP, Mysore, 28 programme), IFIM Business School, Bangalore, 11 July 2014. Target August 2014. Target group: School science teachers. group: MBA students (ii) Anger Management, World Mental Health Day celebrations, MVJ Medical College, Hoskote, 14 October 2014. Target group: MBBS students, MD residents and faculty. Neuropathology
Dr. M Manjula, Associate Professor, (i) Cognitive behaviour therapies: Dr. SK Shankar, Emeritus Professor, Let us learn neuroscience Basic principles and techniques, Karnataka Havyasa Aptasamalochakara together -Take the first step, Science Outreach Programme, Madan Vedike - lecture series, Bangalore, 5 May 2014. Target group: Lay Mohan Malaviya Amphitheater, CNR Rao Hall of Science & counselors (ii) Moral values for healthy living, RJS First Grade College, Education Technology Unit, JNCSAR, Bangalore, 22 August 2014. Bangalore, 25 September 2014. Target group: Students. Target group: School students.
Dr. M Thomas Kishore, Associate Professor, Secular approaches to Dr. BKC Sagar, Additional Professor, Advance microscopy and its counseling, Bangalore, 31 January- 1 February 2015. Target group: application, National Science Day, Bharathi College, Mandya, 28 Lay Counsellors and community volunteers. February 2015. Target group: Undergraduate students.
Dr. Aruna Rose Mary Kapanee, Assistant Professor, Adolescent Dr. Anita Mahadevan, Additional Professor, Of all creatures great and mental health, World Mental Health Day celebrations, Sudarshan small, Program in biology for students, Science Outreach Programme, Vidya Mandir, Bengaluru, 18 October 2014. Target group: 10-12th CNR Rao Hall of Science & Education Technology Unit, JNCASR, standard students and teachers. Bangalore, 16 December 2014. Target group: High school students.
Mr. Suresh Parmar, Scientist-B, Introduction to neuroscience, Mental Health Education National Degree College (Basavanagudi), Bangalore, 23 February 2015. Target group: Degree students Dr. KS Meena, Assistant Professor (i) (a) Portrayal of women in media and its impact on public perception (b) Sensationalism in media and its psychological impact on society, Sacred Heart’s College, Bangalore, Neurophysiology 25 February 2015. Target group: Students (ii) Gender Sensitivity: A Health Education Approach, Sree Cauvery College of Management, Dr. Bindu M Kutty, Professor, Brain plasticity and cognitive functions, Bangalore, 23 January 2015. Target group: Students (iii) Gatekeeper 10th Youth Interfaith Pilgrimage Programme of the Universal Training in Suicide Prevention, BNE College of Arts and Science, Responsibility of His Holiness Dalai Lama, NIMHANS, 14 May Bangalore, 15 September 2014. Target group: Students. 2014. Target group: Staff and general public.
Neurochemistry Neurovirology
Dr. MM Srinivas Bharath, Additional Professor, (i) Parkinson’s disease: Dr. SN Madhusudana, Professor, Lecture on dog bites and its Overview of disease mechanisms and therapy, Health talk, Rotary Club management, World Rabies Day activity, Mysore, 28 September (northwest branch), Bangalore, 13 July 2014. Target group: Members 2014. Target group: Schoolchildren of Tibetan Monastery.
308 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Nursing The role of service organisations. Sri. Padmavathi Mahila Visva Vidyalayam, Tirupati, 6 December 2014. Target group: Social Work Dr. Sailaxmi Gandhi, Assistant Professor, Preparation for board students and NGO members (iv) Addiction Prevention. Substance examinations, Examination Preparation Camp for SSLC Students Abuse Prevention among the School students, Sri Hombe Gowda organised by Child Development Planning Officer, Sumangali Seva Boys High School, Bangalore, 22 December 2014. Target group: 450 Ashram, Bengaluru, 14 October 2014. Target group: SSLC students High School Students and 30 Teachers (v) Prevention of Smoking. from government schools. Smoking and substance abuse prevention among the employees. BHEL, Bangalore, 29 December 2014. Target group: BHEL- Electronic Division employees (vi) Substance abuse management: sychiatry P Psycho-educational skills, Bharathidasan University, Tiruchirapalli, 31 October 2014. Target group: Higher education teachers. Dr. Naveen Kumar C, Assistant Professor, (i) Stress management, Continuing Education Program, Bangalore, 2 July 2014. Target group: Judges (ii) Mental illnesses, Awareness Programme on Mental Speech Pathology & Audiology Illnesses, Bangalore, 11 October 2014. Target group: Undergraduates students (iii) Assessment of mental and neurological disabilities in Dr. N Shivashankar, Professor and Head (i) Common speech and MVC cases, Continuing Education Program for Senior Civil Judges- hearing disorders: Identification and beyond. Vishwa Seva Kendra, (a) 6 October 2014 (b) 14 October 2014 (c) 27 October 2014 (d) 24 Bangalore, 19 July 2014. Target group: General Public (ii) Identification November 2014 (e) 1 December 2014. and referral of school going children with communication disorders. World Mental Health Day celebrations, Kolar, Karnataka, 10 October Dr. Prabhat Chand, Associate Professor, Tobacco addiction: A public 2014. Target group: High school teachers. health problem. Sensitization workshop, Kendriya Sadan, Bangalore, 30 July 2014. Target group: Kendriya Sadan staff. Dr. N Shivashankar, Professor and Head, Dr. Aravind Kumar, Speech Therapist, Stuttering: Q&A interactive meeting with Stutterer’s Self Dr. Pratima Murthy, Professor, Sensitivity, strength and speaking Help Group, Bangalore, 7 September 2014. Target group: Members up: Addressing sexual harassment. International Women’s Day of Stuttering Self Help Group. celebrations, NIMHANS, Bangalore, 16 March 2015. Target group: Dr. BK Yamini, Assistant Professor, along with Speech Therapists Students Dr. Aravind Kumar, Dr. Pradeep Y, Ms. SS Meera, Yogakshema- Health fair for senior citizens (awareness programme), Rotary Club Psychiatric Social Work (Bangalore West), Silver Jubilee Hall, Government Girls PU College, Bangalore, 25-26 January 2015. Target group: Senior citizens and Dr. K Sekar, Professor, Enhancing mental health. Jayanagar Study general public. Centre, Bangalore, 23 August 2014. Target group: Centre members. Psychiatric Rehabilitation Dr. N Krishna Reddy, Additional Professor, Talk on (i) A sound mind in a sound body. Karnataka Gandhi Memorial Trust, Gandhi Bhavan, Dr. Jagadisha Thirthalli, Additional Professor of Psychiatry, Dr. T Bengaluru, 15 August 2014. Target group: General public and lay Sivakumar, Assistant Professor of Psychiatry, Sensitization programme counselors (ii) The importance of natural hygiene in the present about mental illness and rehabilitation, Davangere, Karnataka, 12 scenario. Naturopathy Institute, Malleswaram Bengaluru, 2 February August 2014. Target group: Government officials from Davangere 2015. Target group: General public and lay counselors. district.
Dr. BP Nirmala, Associate Professor, Sensitization programme for Dr. BP Nirmala, Associate Professor of Psychiatric Social Work, psychiatric rehabilitation, Halasur, Bangalore, 5 August 2014. Target Sensitization programme about psychiatric rehabilitation, Bangalore, group: B.Sc. Rehab Students. 5 August 2014. Target group: BSc Rehabilitation Students.
Dr. R Dhanasekara Pandian, Additional Professor, (i) Stress Dr. T Sivakumar, Assistant Professor of Psychiatry (i) Discussion Management. Stress Management Workshop, Karnataka State on New Disability Law, Karnataka Parents Association for mentally Pollution Control Board, Bangalore, 7 April 2014. Target group: retarded children, Bangalore, 6 July 2014. Target group: professionals Department personnel/officials (ii) Addiction Prevention. Substance and parents (ii) Welfare benefits for persons with mental illness, abuse prevention among school students. Narmada Memorial School, World Mental Health Week celebrations of RFS (Richmond
Bangalore, 26 November 2014. Target group: High school students Fellowship Society) ASHA, Bangalore, 15 October 2014. Target and teachers (iii) Current needs of social welfare services in society: group: Caregivers and rehabilitation professionals.
National Institute of Mental Health and Neuro Sciences 309|
Statutory Bodies
Institute Body
1. Shri. Jagat Prakash Nadda President 9. Chief Secretary to Government of Member Hon’ble Union Minister for Karnataka Health and Family Welfare Bangalore – 560001 Government of India 10. Prof. K. Vijay Raghavan Member Nirman Bhavan, New Delhi – 110 011 Secretary, Department of Biotechnology 2. Dr. Sharanprakash R. Patil Vice-President Government of India Hon’ble Minister of State for New Delhi – 110 003 Medical Education 11. Dr. V.S. Chauhan Member Government of Karnataka Director Vidhana Soudha, Bangalore – 560 001 International Centre of Genetic Engineering 3. Secretary (Health) Member and Biotechnology Ministry of Health & Family Welfare New Delhi – 110 067 Government of India 12. Dr. Vikram Patel Member Nirman Bhavan Professor of International Mental Health New Delhi – 110 011 London School of Hygiene and Tropical 4. Dr. P. Satish Chandra Member Secretary Medicine Director/Vice-Chancellor London and Sangath, Goa NIMHANS, Bangalore – 560 029 13. Dr. Ramesh Budhani Member 5. Secretary to Government of India Member Director Department of Expenditure National Physical Laboratory Ministry of Finance, New Delhi – 110 001 New Delhi – 110012
6. Secretary to Government of India Member 14. Justice (Retd.) Prabha Sridevan Member Higher Education Department Chairperson Ministry of Human Resource Development Intellectual Property Appellate Tribunal New Delhi – 110 001 Chennai – 600 018
7. Dr. Jagadish Prasad Member 15. Shri. Amrit Kumar Bakshy Member Director General of Health Services President Government of India Schizophrenia Awareness Association Nirman Bhavan Pune – 411041 New Delhi – 110 011 16. Dr. R. Thara Membe 8. Dr. K.S. Ravindranath Member Director Vice-Chancellor Schizophrenia Research Foundation Rajiv Gandhi University of Health Sciences, (SCARF) Karnataka, Bangalore – 560 041 Chennai – 600101
National Institute of Mental Health and Neuro Sciences 311| Annual Report 2014-15
17. Prof. Shobha Srinath Member 20. Dr. V. Ravi Member Professor, Child and Adolescent Psychiatry Professor and Head, Neurovirology National Institute of Mental Health and National Institute of Mental Health Neuro Sciences and Neuro Sciences, Bangalore – 560 029 Bangalore – 560 029 21. Shri. Mallikarjun Kharge Member 18. Dr. S.K. Pandya Member Member of Parliament Retd. Head of the Department, Neurosurgery Lok Sabha King Edward Memorial Hospital 22. Shri. P.C. Mohan Member Mumbai – 400 012 Member of Parliament 19. Dr. Bhabatosh Biswas Member Lok Sabha Prof. and Head, Cardio and Thoracic Surgery 23. Dr. M.V. Rajeev Gowda Member R.G. Kar Medical College Member of Parliament Kolkata – 700002 Rajya Sabha
Governing Body
Hon’ble Minister for Health and Family Chairman Dr. R. Thara Member Welfare Director, Schizophrenia Research Foundation Government of India and President, (SCARF), Chennai – 600101 NIMHANS, Bangalore Prof. Vijay Raghavan Member Secretary Member Secretary, Department of Biotechnology Dept. of Health and Family Welfare or Ministry of Science and Technology, his nominee Government of India
Dr. Jagadish Prasad Member Dr. Bhabatosh Biswas Member Director General Health Services Prof. and Head, Cardio and Thoracic Surgery R.G. Kar Medical College, Kolkata – 700002 Ms. Vijaya Srivastava Member Additional Secretary & Financial Adviser Ministry of Health and Family Welfare Dr. T.R. Raju Member Senior Professor, Dept. of Neurophysiology NIMHANS, Bangalore Prof. P. Satishchandra Member Secretary Director/Vice-Chancellor NIMHANS, Bangalore Dr. G.S. Umamaheswara Rao Member Senior Professor Dept. of Neuroanaesthesia Chief Secretary Member NIMHANS, Bangalore Govt. of Karnataka or his nominee
Dr. Shoba Srinath Member Prof. M. Jayaram Member Professor, Dept. of Child & Adolescent Senior-most Dean & Sr. Professor Psychiatry Department of Speech Pathology & Audiology NIMHANS, Bangalore NIMHANS, Bangalore
Prof. G.N. Narayana Reddy Member Shri. P.C. Mohan Member Former Director Member of Parliament NIMHANS, Bangalore Banashankari, Bangalore
312 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Standing Finance Committee
1 Secretary Chairman 5 Dr. Thara Member Ministry of Health and Family Welfare Schizophrenia Research Government of India Foundation (SCARF), Chennai
2 Dr. Jagadish Prasad Member 6 Dr. Ramesh Budhani Member Director, General Health Services Director National Physical Laboratory, New Delhi 3 Additional Secretary & Financial Adviser Member Ministry of Health and Family Welfare 7 Dr. V. Ravi Member Government of India Registrar NIMHANS, Bangalore 4 Vice-Chancellor Member Rajiv Gandhi University of Health Sciences 8 Prof. P. Satishchandra Member Secretary Bangalore Director/Vice-Chancellor NIMHANS, Bangalore
Academic Committee
1. Prof. Vijay Raghavan Chairman 7. Prof. Bhabatosh Biswas Member Secretary, Department of Biotechnology R.G. Kar Medical College & Hospital Ministry of Science and Technology Kolkata Government of India 8. Dr. GS Umamaheswara Rao Member 2. Dr. V.S. Chauhan Member Dean International Centre for Genetic NIMHANS, Bangalore Engineering and Biotechnology New Delhi 9. Dr. Shoba Srinath Member Professor 3. Vice-Chancellor Member Dept. of Child & Adolescent Psychiatry Rajiv Gandhi University of Health Sciences NIMHANS, Bangalore Bangalore 10. Dr. V. Ravi Member 4. Prof. K.V.R. Sastry Member Prof & Head Neurosurgeon Dept. of Neurovirology Medwin Hospitals NIMHANS, Bangalore Hyderabad 11. Prof. Smitha Deshpande Member 5. Dr. Padma Srivastava Member Head, Dept. of Psychiatry Professor, Dept. of Neurology Dr. RML Hospital, AIIMS, New Delhi New Delhi
6. Prof. A.V. Srinivasan Member 12. Dr. P. Satishchandra Member-Secretary Institute of Neurology, Madras Medical Director/Vice-Chancellor College, Chennai NIMHANS, Bangalore
National Institute of Mental Health and Neuro Sciences 313| Annual Report 2014-15
Planning And Monitoring Committee
1 Dr. M.V. Rajeev Gowda Chairman 5 Prof. Ravikumar J.S. Member Member of Parliament (Rajya Sabha) Director JIPMER, Puducherry 2 Dr. S.K. Pandya Member Neurosurgeon, KEM Hospital, Mumbai 6 Prof. D.N. Rao Member IISc, Bangalore 3 Prof. Vijay Raghavan Member Secretary, Department of Biotechnology 7 Prof. P. Satishchandra Member Secretary Director/Vice-Chancellor 4 Dr. Vikram Patel Member NIMHANS, Bangalore Public Health Foundation of India, Delhi
Standing Estate Committee
1. Justice (Rtd.) Prabha Sridevan Chairperson 5. Dr. Shoba Srinath Member Chairman, IPA Professor, Dept. of Child & Adolescent Chennai Psychiatry NIMHANS, Bangalore 2. Vice-Chancellor Member Rajiv Gandhi University 6. Dr. M. Jayaram Member Bangalore Sr. Prof., Department of Speech Pathology & Audiology 3. Dr. C.S. Viswanatha Member NIMHANS, Bangalore Retd. Engineer, IISc, Bangalore & Former Chairman, Task Force on Quality 7. Dr. V.L. Satheesh Member Constructions Medical Superintendent Govt. of Karnataka NIMHANS, Bangalore
4. Prof. Bhabatosh Biswas Member 8. Prof. P. Satishchandra Member Secretary R.G. Kar Medical College & Hospital Director/Vice-Chancellor Kolkata NIMHANS, Bangalore
Hospital Management Committee
1. Shri. Amrit Kumar Bakshy Chairman 6. Dr. Shoba Srinath Member President, Schizophrenia Awareness Professor Association, Pune Dept. of Child & Adolescent Psychiatry NIMHANS, Bangalore 2. Shri. Mallikarjun Kharge Member Member of Parliament 7. Dr. A.B. Taly Member Government of India, New Delhi Professor Dept. of Neurology 3. Dr. Prof. B.N. Gangadhar Member NIMHANS, Bangalore Dept. of Psychiatry NIMHANS, Bangalore 8. Dr. V.L. Satheesh Member Medical Superintendent 4. Dr. Thara Member NIMHANS, Bangalore SCARF, Chennai 9. Prof. Satish Chandra Member Secretary 5. Dr. G. S. Umamaheswara Rao Member Director/Vice-Chancellor Senior Professor, Dept. of Neuroanaesthesia NIMHANS, Bangalore NIMHANS, Bangalore
314 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Board of Studies
Basic Sciences
1 Dr V. Ravi Chairman 6 The Head Member Dean (Basic Sciences) Department of Human Genetics Prof. & Head, Dept. of Neurovirology, NIMHANS, Bangalore NIMHANS, Bangalore. 7 The Head Member 2 Dr. Udaykumar Ranga Member Department of Neurochemistry Professor NIMHANS, Bangalore Molecular Biology & Genetics Unit Jawaharlal Nehru Centre for Advanced 8 The Head Member Scientific Research Jakkur (P.O.) Department of Neuromicrobiology Bangalore – 560 064. NIMHANS, Bangalore
3 Dr. Saumitra Das Member 9 The Head Member Professor Department of Neurophysiology Dept. of Microbiology & Cell Biology NIMHANS, Bangalore Indian Institute of Science 10 The Head Member Bangalore – 560 012 Department of Neurovirology 4 The Head Member NIMHANS, Bangalore Department of Biophysics 11 The Head Member NIMHANS, Bangalore Department of Psychopharmacology 5 The Head Member NIMHANS, Bangalore Department of Biostatistics NIMHANS, Bangalore
Behavioural Sciences
1 Dr. B.N. Gangadhar Chairman 5 The Head Member Dean (Behavioural Sciences) Department of Clinical Psychology Professor, Dept. of Psychiatry NIMHANS, Bangalore NIMHANS, Bangalore 6 The Head Member 2 Dr. P.S.V.N. Sharma Member Department of Health Education Professor of Psychiatry NIMHANS, Bangalore Dept. of Psychiatry Kasturba Medical College 7 The Head Member Manipal – 576 119. Department of Nursing NIMHANS, Bangalore 3 Dr. Tanya Machado Member Professor of Clinical Psychology 8 The Head Member Dept. of Psychiatry Department of Psychiatric Social Work St. John’s Medical College & Hospital NIMHANS, Bangalore Bangalore – 560 034 9 The Head Member 4 The Head Member Department of Psychiatry Department of Child & Adolescent NIMHANS, Bangalore Psychiatry NIMHANS, Bangalore
National Institute of Mental Health and Neuro Sciences 315| Annual Report 2014-15
Neuro Sciences
1 Dr. M. Jayaram Chairman 7 The Head Member Dean (Neuro Sciences) Department of Neuroanaesthesia Sr. Professor NIMHANS, Bangalore Dept. of Speech Pathology & Audiology NIMHANS, Bangalore 8 The Head Member Department of Neurosurgery 2 Dr. Rupam Borgohain Member NIMHANS, Bangalore Professor of Neurology Nizam’s Institute of Medical Sciences 9 The Head Member (NIMS), Panjagutta, Hyderabad – 500 482. Department of Neurology NIMHANS, Bangalore 3 Dr. Ravi Gopal Varma (17.08.2012 - 16.08.2015) Member Prof. & Head, Dept. of Neurosurgery 10 The Head Member M. S. Ramaiah College, Bangalore Department of Neuro Imaging & Interventional Radiology 4 Dr. Mathew Alexander (03.02.2015 - 02.02.2018) Member NIMHANS, Bangalore Professor & Head, Neurology Unit Christian Medical College 11 The Head Member Ida Scudder Road, Vellore Department of Neuropathology Tamil Nadu - 632 004 NIMHANS, Bangalore
5 The Head Member 12 The Head Member Department of Epidemiology Department of Neurological Rehabilitation NIMHANS, Bangalore – 560 029 NIMHANS, Bangalore
6 The Head Member 13 The Head Member Department of Clinical Neurosciences Department of Speech Pathology & (Virtual Department) Audiology NIMHANS, Bangalore NIMHANS, Bangalore
Rehabilitation Committee
1. Dr. P. Satishchandra Chairperson 7. Dr. Ravishankar Member Director/Vice-Chancellor Consultant Orthopedic Surgeon NIMHANS, Bangalore St. Philomena’s Hospital No:1, Campbell Road 2. Dr.V. Ravi Member Vivek Nagar, Registrar Bangalore- 560 047 NIMHANS, Bangalore 8. Dr.S. Kalyanasundaram, Member 3. Professor & Head Member Consultant Psychiatrist Dept. of Psychiatry Richmond Fellowship NIMHANS, Bangalore “Asha”, No: 501, 47th Cross, 9th Main, 4. Professor & Head Member V Block, Jayanagar Dept. of Neurological Rehabilitation Bangalore- 560 041 NIMHANS, Bangalore. 9. Ms. Shanthi Raghavan Member 5. Mr. Subroto Bagchi Member Founder Chairman & CEO EnAble India Mindtree Limited No:12, KHB Colony (Ground Floor) RVCE Post, Mysore Road, Bangalore Brahma Kumari’s Road, Koramangala 8thBlock, Bangalore-560 095 6. Dr. A. Mohan Member Professor & Head, Department of Genito 10. Ms. Suchetha Kulu Member Urinary Surgery “Friends of NIMHANS” St. John’s Medical College and Hospital 530, 5th Cross, Mahalaxmi Layout Bangalore Bangalore–560 086
316 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
11. Dr. Kurien Zachariah Member 16. Professor & Head Member Professor and Head, Department of Physical Dept. of Neurology Medicine & Rehabilitation NIMHANS, Bangalore St. Johns Medical College & Hospital Bangalore–560 034 17. Professor & Head Member Dept. of Psychiatric Social Work 12. Ms. Ruma Banerji, Member NIMHANS, Bangalore Vice Chairperson, SEVA-IN Action Koramangala, Bangalore- 560 039. 18. Professor & Head Member Dept. of Speech Pathology & Audiology 13. Mr. Pranesh S Member NIMHANS, Bangalore Managing Director, Prism Books Private Limited, Banashankari, Bangalore–560 070 19. Professor & Head Member Dept. of Nursing 14. Professor & Head Member NIMHANS, Bangalore Dept. of Clinical Psychology NIMHANS, Bangalore 20. Dr.S.K.Chaturvedi Member-Secretary Professor & Head, Dept. of Psychiatric 15. Professor & Head Member Rehabilitation Services Dept. of Neurosurgery NIMHANS, Bangalore NIMHANS, Bangalore
Human Ethics Committee
1. Dr. Anura Vishwanath Kurpad Chairman 7. Dr. G. Gururaj Member Professor of Physiology (Medical Doctor) Prof. of Epidemiology St. John’s Medical College, St. John’s NIMHANS, Bangalore National Academy of Health Sciences 8. Dr.Bindu M. Kutty Member Sarjapur Road, Bangalore – 560 034 Prof. of Neurophysiology 2. Dr. Udaykumar Ranga Member NIMHANS, Bangalore Professor (Scientist) 9. Dr. Pratima Murthy Member HIV-AIDS Laboratory, Molecular Biology Professor of Psychiatry and Genetics Unit, Jawaharlal Nehru NIMHANS, Bangalore Centre for Advanced Scientific Research Jakkur (PO), Bangalore – 560 064 10. Dr. Pramod Kumar Pal Member Professor of Neurology 3. Dr. Geetha Member NIMHANS, Bangalore Professor of Pharmacology, Dept. of (Pharmacologist) Pharmacology, Bangalore Medical College, 11. Dr. Srikala Bharath Member Bangalore – 560 002 Prof. of Psychiatry NIMHANS, Bangalore 4. Dr. Ashok R. Patil Member Professor of Law (Legal Expert) 12. Dr. M. Jayaram Member Chair on Consumer Law & Practice, Sr. Professor of Speech Pathology and National Law School of India University, Audiology, and Dean (Neuro Sciences) Post Bag No.7201, Nagarbhavi, Bangalore NIMHANS, Bangalore – 560 072 13. Dr. V. Ravi Member 5. Dr. Rajaram Subbian Member Professor of Neurovirology, and No.C410, Cassia (Social Scientist) Dean (Basic Sciences) NIMHANS, Brigade Millennium, Bangalore – 560 029 Bangalore 6. Ms. Ammu Joseph Member 14. Dr. B.N. Gangadhar Member – Secretary Independent Journalist and Author (Community Professor of Psychiatry, and Dean No.71, S.T. Bed Layout, Representative/ (Behavioural Sciences) NIMHANS, Koramangala, Bangalore – 560 034 Lay Person) Bangalore
National Institute of Mental Health and Neuro Sciences 317| Annual Report 2014-15
Animal Ethics Committee
1. Dr. S.N. Madhusudana Chairman 6. Dr. M.R. Gajendragad Nominee Professor and Head, Principal Scientist, Epidemiology Unit, CPCSEA Dept. of Neurovirology ICAR - National Institute of Veterinary NIMHANS, Bangalore. Epidemiology and Disease Informatics 2. Dr. Anita S. Desai Member (NIVEDI), Indian Council of Agricultural Professor, Dept. of Neurovirology Research, Post Box No. 6450 NIMHANS,Bangalore Ramagondanahalli, Yelahanka, Bengaluru - 560064 3. Dr. Dhananjaya I. Bhat Member 7. Member Additional Professor, Dept. of Dr. S. Ramachandra Scientist from Neurosurgery, NIMHANS, Bangalore Professor and HOD, Pharmacology Government College of Pharmacy, outside the institute 4. Dr. M. M. Srinivas Bharath Member Subbaiah Circle, P. Kalinga Rao Road, Additional Professor, Dept. of Bengaluru 560 027 Neurochemistry, NIMHANS, Bangalore 8. Mr. D.R. Prahallada Member 5. Dr. J. Suresh Chandra Member - Secretary No. 140/1, (2nd Floor), Chinmayee Nilaya, (Non-Scientific Sr.Veterinary Officer National Park Road, Bannerughatta, Socially aware) CARF, NIMHANS, Bangalore Bangalore - 560 083
Ph.D Committees
Basic Sciences
1 Dean (Basic Sciences) Chairman 6 The Head Member NIMHANS, Bangalore Department of Neurochemistry NIMHANS, Bangalore 2 Dr. Anura V. Kurpad Member Professor, Department of Physiology 7 The Head Member St. John’s Medical College, Department of Neuromicrobiology Bangalore – 560 034 NIMHANS, Bangalore
3 Dr. Arun Kumar Member 8 The Head Member Professor, Department of Molecular Department of Neurophysiology Reproduction Development & Genetics NIMHANS, Bangalore Indian Institute of Science, Bangalore – 560 012 9 The Head Member Department of Neurovirology 4 The Head Member Bangalore Department of Biophysics NIMHANS, Bangalore 10 The Head Member Department of Psychopharmacology 5 The Head Member NIMHANS, Bangalore Department of Human Genetics NIMHANS, Bangalore
318 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Behavioural Sciences
1 Dean (Behavioural Sciences) Chairperson 5 The Head NIMHANS, Bangalore Department of Clinical Psychology NIMHANS, Bangalore 2 Dr. R.B. Galgali Member Professor 6 The Head Department of Psychiatry Department of Health Education St. John’s Medical College Hospital NIMHANS, Bangalore Bangalore – 560 034 7 The Head 3 Dr. Rameela Shekhar Member Department of Nursing Professor of Medical & Psychiatric Social NIMHANS, Bangalore Work and Dean, PG Department School of Social Work 8 The Head Roshini Nilaya, Mangalore - 02 Department of Psychiatric Social Work NIMHANS, Bangalore 4 The Head Department of Child & Adolescent 9 The Head Psychiatry Department of Psychiatry NIMHANS, Bangalore NIMHANS, Bangalore
Neuro Sciences
1 Dean (Neuro Sciences) Chairman 7 The Head Member NIMHANS, Bangalore Department of Neuro Imaging & Interventional Radiology 2 Dr. B. Vengamma Member NIMHANS, Bangalore Professor and Head of Neurology Director, Sri Venkateswara Institute of 8 The Head Member Medical Sciences, Tirupati - 517 507, Department of Neurological Rehabilitation Andhra Pradesh NIMHANS, Bangalore
3 Dr. V. Rajshekhar Member 9 The Head Member Professor of Neurosurgery and Head, Department of Neurology Neurosurgery Unit II, Department of NIMHANS, Bangalore Neurological Sciences, Christian Medical College. IDA Scudder Road 10 The Head Member Vellore – 632 004 (T.N.) Department of Neuropathology NIMHANS, Bangalore 4 The Head Member Department of Clinical Neurosciences 11 The Head Member (Virtual Department), NIMHANS, Department of Neurosurgery Bangalore NIMHANS, Bangalore
5 The Head Member 12 The Head Member Department of Epidemiology Department of Speech Pathology & NIMHANS, Bangalore Audiology NIMHANS, Bangalore 6 The Head Member Department of Neuroanaesthesia NIMHANS, Bangalore
National Institute of Mental Health and Neuro Sciences 319| Ravi Hegde Faculty and Staff
Dean
Dr. G.S. Umamaheshwara Rao Sr. Professor and Dean, Clinical Neurosciences (till 15.6.2014) Dr. M. Jayaram Sr. Professor and Dean, Neurosciences (w.e.f.16.6.2014) Dr. Shobha Srinath Professor and Dean, Behavioural Sciences (till 15.6.2014) Dr. B.N. Gangadhar Professor and Dean, Behavioural Sciences (w.e.f.16.6.2014) Dr. D.K. Subbakrishna Professor and Dean, Basic Sciences (till 15.6.2014) Dr. V. Ravi Professor and Dean, Basic Sciences (w.e.f.16.6.2014)
Biophysics
Dr. Preeti G. Joshi Professor & Head Dr. Vijay Kumar Kalia Professor Dr. Balasundaram Padmanabhan Additional Professor Dr. Indrani Datta Assistant Professor
Biostatistics
Dr. D.K. Subbakrishna Professor& Head Dr. K. Thennarasu Professor Dr. P. Marimuthu Additional Professor Dr. Mariyamma Philip Assistant Professor Dr. Binukumar B. Assistant Professor
Child & Adolescent Psychiatry
Dr. Satish Chandra Girimaji Professor & Head Dr. Shoba Srinath Sr. Professor Dr. Shekar P. Seshadri Professor Dr. K. John Vijay Sagar Additional Professor
Clinical Neurosciences (Virtual Department)
Dr. Vani Santosh Professor of Neuropathology & Head of Clinical Neurosciences Dr. John P. John Professor of Psychiatry Dr. Ravi Yadav Associate Professor of Neurology
Clinical Psychology
Dr. M.P. Sharma Professor & Head Dr. Ahalya Raguram Professor Dr. H. Uma Professor
National Institute of Mental Health and Neuro Sciences 321| Annual Report 2014-15
Dr. Anisha Shah Professor Dr. L.N. Suman Professor Dr. Seema Mehrotra Professor Dr. Jamuna Rajeshwaran Additional Professor Dr. Paulomi Matam Sudhir Additional Professor Dr. J. Keshav Kumar Additional Professor Dr. Manoj Kr. Sharma Additional Professor Dr. M.Manjula Additional Professor Dr. Devvarta Kumar Additional Professor Dr. Poornima Bhola Associate Professor Dr. Thomas Kishore M. Associate Professor Dr. B.N. Roopesh Associate Professor Dr. Shantala Hegde Assistant Professor Dr. Veena A.S. Assistant Professor Dr. Aruna Rose Mary Kapanee Assistant Professor
Epidemiology
Dr. G. Gururaj Professor & Head Dr. N. Girish Additional Professor Dr. Pradeep B.S. Associate Professor Dr. Gautham M.S. Assistant Professor Dr. Vivek Gupta Assistant Professor (Resigned on 01.02.2015) Dr. Senthil Amudhan R. Assistant Professor
Human Genetics
Dr. Rajalakshmi Gope Professor & Head Dr. G.K. Chetan Additional Professor Dr. Monojit Debnath Assistant Professor
Mental Health Education
Dr. Jayashree Ramakrishna Professor & Head Dr. K.S. Meena Assistant Professor
Neuroanaesthesia
Dr. K.R. Madhusudan Reddy Professor & Head Dr. G.S. Umamaheswara Rao Sr. Professor Dr. V. Bhadrinarayan Professor Dr. V.J. Ramesh Professor Dr. M. Radhakrishnan Additional Professor Dr. K. Sriganesh Associate Professor Dr. Sudhir V. Assistant Professor Dr. Gopala Krishna Assistant Professor Dr. Sonia Bansal Assistant Professor Dr. Rohini M. Surve Assistant Professor of Critical Care
322 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Neurochemistry
Dr. Rita Christopher Professor & Head Dr. Sarada Subramanian Additional Professor Dr. M.M. Srinivas Bharath Additional Professor Dr. Nandakumar D.N. Additional Professor Dr. Kruthika Vinod T.P. Sr. Scientific Officer
Neuro Imaging & Interventional Radiology
Dr. Arun Kumar Gupta Professor & Head Dr. Rose Dawn Bharath Additional Professor Dr. Hima Shriniwas Pendharkar Associate Professor Dr. Arvinda H.R. Associate Professor Dr. Jitendra Saini Associate Professor Dr. Chandrajit Prasad Associate Professor Dr. Maya Dattatraya Bhat Associate Professor
Neurological Rehabilitation
Dr. Arun Kumar B.Taly Professor of Neurology & I/C Head Dr. Anupam Gupta Additional Professor Dr. Meeka Khanna Assistant Professor
Neurology
Dr. P. Satishchandra Sr. Professor & Director / Vice-Chancellor Dr. A. Nalini Professor & Head Dr. Arun Kumar B.Taly Professor Dr. M. Veerendra Kumar Professor Dr. S.R. Chandra Professor Dr. Pramod Kumar Pal Professor Dr. Sanjib Sinha Professor Dr. P.S. Bindu Additional Professor Dr. P.S. Mathurnath Additional Professor Dr. Girish Baburao Kulkarni Additional Professor Dr. Ravi Yadav Associate Professor Dr. Netravathi M. Associate Professor Dr. Subasree R. Assistant Professor Dr. Madhu N. Assistant Professor
Neuromicrobiology
Dr. R. Ravikumar Professor & Head Dr. Shripad A. Patil Professor Dr. S. Nagarathna Professor Dr. H.B. Veena Kumari Additional Professor
National Institute of Mental Health and Neuro Sciences 323| Annual Report 2014-15
Neuropathology
Dr. S.K. Shankar Emeritus Professor Dr. T.C. Yasha Professor & Head Dr. Vani Santosh Professor Dr. Sundar Periyavan Professor Dr. N. Gayathri Professor Dr. Anita Mahadevan Additional Professor Dr. B.K. Chandrasekhar Sagar Additional Professor Dr. Nandeesh B.N. Assistant Professor Dr. Sangeetha Seshagiri K. Sr. Clinical Pathologist
Neurophysiology
Dr. T.R. Raju Sr. Professor & Head Dr. Bindu M. Kutty Professor Dr. T.N. Sathyaprabha Professor Dr. B.S. Shankaranarayana Rao Professor Dr. Laxmi T. Rao Additional Professor Dr. Phalguni Anand Alladi Sr. Scientific Officer
Neurosurgery
Dr. R.M. Verma Emeritus Professor (Expired on 10-03-2015) Dr. B. Indira Devi Professor & Head Dr. Malla Bhaskara Rao Professor Dr. S. Sampath Professor Dr. Paritosh Pandey Additional Professor (Resigned on 01.10.2014) Dr. Dhananjaya I. Bhat Additional Professor Dr. Dwarakanath Srinivas Additional Professor Dr. Dhaval P. Shukla Additional Professor Dr. A. Arivazhagan Additional Professor Dr. Nupur Pruthi Additional Professor Dr. KVL Narasinga Rao Additional Professor Dr. Jagath Lal G. Associate Professor (Resigned on 14.08.2014) Dr. Manish Ranjan Associate Professor (Resigned on 28.09.2014) Dr. V. Vikas Associate Professor Dr. A.R. Prabu Raj Assistant Professor Dr. Amey Rajan Savardekar Assistant Professor Dr. Manjul Tripathi Assistant Professor Sri. N. Ponnuswamy Sr. Scientific Officer (Radiation Safety)
Neurovirology
Dr. V. Ravi Professor & Head Dr. S.N. Madhusudana Professor Dr. Anita S. Desai Professor Dr. Reeta Subramaniam Mani Associate Professor Dr. Manjunatha V. Senior Scientific Officer
324 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Nursing
Dr. K. Lalitha Professor & Head Dr. Ramachandra Additional Professor Dr. Sai Laxmi Gandhi Associate Professor Dr. Prasanthi Nattala Assistant Professor Dr. G. Radhakrishnan Assistant Professor
College of Nursing
Dr. Ramachandra Principal Dr. Pratibha Swamy Associate Professor Ms. Jayanthi K.N. Lecturer Mr. Jayakumar B. Lecturer Mrs. Asha Anita D’Souza Lecturer Mrs. Poornima H.N. Lecturer Mrs. Priya Baby Lecturer Mrs. D. Kanitha Lecturer Dr. S. Valliammal Lecturer Dr. Rajeswari C. Lecturer Ms. Jeeva S. Lecturer
Psychiatry
Dr. Mathew Varghese Professor & Head Dr. Ravishankar Pandey Professor Dr. Sanjeev Jain Professor Dr. S.K. Chaturvedi Professor Dr. B.N. Gangadhar Professor Dr. Prabha S. Chandra Professor Dr. Pratima Murthy Professor Dr. Srikala Bharath Professor Dr. Y.C. Janardhana Reddy Professor Dr. Vivek Benegal Professor Dr. John P. John Professor Dr. Jagadisha Thirthalli Professor Dr. B.M. Suresh Additional Professor Dr. G. Venkatasubramanian Additional Professor Dr. P.T. Sivakumar Additional Professor Dr. Geetha Desai Additional Professor Dr. Shivarama Varambally Additional Professor Dr. Prabhat Kumar Chand Additional Professor Dr. K. Muralidharan Additional Professor Dr. T. Harish Additional Professor Dr. Santosh Loganathan Associate Professor Dr. V. Senthil Kumar Reddi Associate Professor Dr. C. Naveen Kumar Associate Professor Dr. Shyam Sundar A. Associate Professor Dr. Arun K. Assistant Professor Dr. Preethi Sinha Assistant Professor
National Institute of Mental Health and Neuro Sciences 325| Annual Report 2014-15
Dr. Sydney Moirangathem Assistant Professor Dr. T. Sivakumar Assistant Professor Dr. Janardhanan C.N. Assistant Professor (DST- INSPIRE) Dr. Biju Viswanath Assistant Professor (DST- INSPIRE) Dr. Urvaksh Mehta Assistant Professor (DBT-Wellcome) Dr. Sabina Rao Psychiatrist (Special Grade) Dr. Shashidhara H.N. Psychiatrist (Specialist Grade)
Psychiatric Rehabilitation
Dr. S.K. Chaturvedi Professor of Psychiatry & I/C Head Dr. Jagadisha Thirthalli Professor of Psychiatry Dr. Geetha Desai Additional Professor of Psychiatry Dr. Devvarta Kumar Associate Professor of Clinical Psychology Dr. Poornima Bhola Associate Professor of Clinical Psychology Dr. B.P. Nirmala Additional Professor of Psychiatric Social Work Dr. Sai Laxmi Gandhi Associate Professor of Nursing Dr. C. Naveen Kumar Associate Professor of Psychiatry Dr. Sivakumar T. Assistant Professor of Psychiatry
Psychiatric Social Work
Dr. K. Sekar Professor & Head Dr. R. Parthasarathy Sr. Professor Dr. D. Muralidhar Professor Dr. N. Krishna Reddy Additional Professor Dr. Prakashi Rajaram Additional Professor (Retired on 30.09.2014) Dr. R. Dhanasekara Pandian Additional Professor Dr. A. Thirumoorthy Additional Professor Dr. Mohammed Ameer Hamza Additional Professor Dr. B.P. Nirmala Additional Professor Dr. N. Janardhana Associate Professor Dr. Vranda M.N. Assistant Professor Dr. Kavitha V. Jangam Assistant Professor Dr. E. Aravind Raj Assistant Professor Dr. Gobinda Majihi Assistant Professor
Psychopharmacology
Dr. Chittaranjan Andrade Professor & Head Dr. N. Pradhan Sr. Professor
Speech Pathology & Audiology
Dr. N. Shivashankar Professor & Head Dr. M. Jayaram Sr. Professor Dr. Vandana V.P. Assistant Professor Dr. B.K. Yamini Assistant Professor
326 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Ayurvedic Research Unit
Dr. D. Sudhakar Assistant Director Dr. S.K. Tiwari Research Officer Dr. B. Chendrasekhara Rao Research Officer Dr. Sulochana Bhat Research Officer Dr. Srinibash Sahoo Research Officer Dr. G.V. Ramana Research Officer Dr. Hemanth Kumar Gupta Research Officer
Biomedical Engineering Section
Smt. M.G. Sindu Biomedical Engineer Sri. J. Nataraja Sr. Scientific Assistant, Biomedical Engineer, Gr, II Sri. S.N. Jein Sr. Scientific Assistant, Biomedical Engineer, Gr. II Sri. Elangovan Hardware & Network Engineer
Central Animal Research Facility
Dr. J. Sureshchandra Sr. Veterinary Officer (Retired on 31.12.2014)
Library & Information Services
Dr. Jayaram M. Sr. Professor and Officer I/c Dr. B.R. Bhanumathi Yadav Senior Librarian (Retired on 30.04.2014) Sri. P. Sulochanan Librarian Smt. Lalitha Koti Librarian Sri. Prasad N.N. Librarian
Publication Department
Dr. Jayaram M. Sr. Professor and Officer I/c Sri. Prabhu Dev M. Assistant Editor Smt. Tejaswini A. Proof Reader
Public Relations
Sri. Praseed Kumar Public Relations Officer Sri. A.S. Elias Assistant Public Relations Officer (Retired on 31.01.2015) Sri. A.S. Revappa Assistant Horticulture Officer
Legal Section
Sri. P. Karunakara Gandhi Legal Assistant (on Deputation)
National Institute of Mental Health and Neuro Sciences 327| Annual Report 2014-15
Internal Auditors
Sri. Kunhikrishnan Consultant Sri. P. Sukumar Internal Audit Officer
Engineering Department
Sri. N.L. Satish AEE & Head Sri B.T. Sridhar Assistant Engineer (Civil) Sri. M.J. Yogesh Assistant Engineer (Civil) Sri. S.H. Sreenivas Assistant Engineer (Civil) Sri. N.R. Nagaraju Assistant Engineer (Civil) Sri. Prakash C.K. Junior Engineer (Electrical) Sri. H.N. Vittal Rao Junior Engineer (Electrical)
Administration
Dr. V. Ravi Registrar Sri. R. Timothy Raj Dy. FA & CAO Sri. D. Rajendran Administrative Officer Sri. M.N. Shankarsa Administrative Officer (A&E) Sri. Venkatesh S. Special Officer (Purchase) Sri. Parameshwara AAO (Co-ordination) Sri. T. Ravi AAO (Claims) Sri. J. Ramaiah AAO (Accounts) (Retired on 30.04.2014) Sri. B. Hanumanthaiah AAO (Staff Section – Adhoc) (Retired on 30.06.2014) Sri. Shankarappa AAO (Accounts) Kum. K. Lakshmikantha AAO (Accounts) (Retired on 31.10.2014) Sri. A. Loganathan Accounts Officer (Retired on 31.08.2014) Sri. B.G. Balarama Accounts Officer
Hospital Administration
Dr. V.L. Sateesh Medical Superintendent Dr. V.S. Chandrashekar Resident Medical Officer (Retired on 31.12.2014) Sri. N. Bhanumathi AAO (RS) I/c (Retired on 30.11.2014) Sri. M. Parameshwara AAO (OPD) Smt. T. Chandramathi AAO (Hospital Staff Section) Sri. G. Pulla Reddy Sr. Medical Records Officer (Retired on 30.06.2014) Sri. Nanjappachar Jr. Medical Records Officer (Reired on 30.09.2014) Dr. M.R. Mohan Kumar Sr. GDMO Dr. T.N. Prathiba Sr. GDMO Dr. Adinath Basarikodi Sr. GDMO (Retired on 31.03.2015) Dr. Mani Ezhilan Sr. GDMO (Retired on 31.07.2014) Dr. A.S.V.L.N. Ravindra Sr. GDMO
328 | National Institute of Mental Health and Neuro Sciences Ravi Hegde Annual Report 2014-15 Finance and Accounts
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Balance Sheet as at 31st March 2015
(Rs. In Lakh) CORPUS / CAPITAL FUND & LIABILITIES SCHEDULE 2014-15 2013-14
CAPITAL FUND 1 28,475.81 28,964.09
ASSET RESERVE-PROJECTS 5 2,800.19 2,671.22
PROJECTS, SEMINARS, WORKSHOPS, ETC., 2 1,248.86 870.18
EARMARKED / ENDOWMENT FUNDS 3 44,131.88 29,962.61
CURRENT LIABILITIES AND PROVISIONS 4 3,197.22 3,137.45
TOTAL 79,853.96 65,605.55
ASSETS
FIXED ASSETS 5 28,009.89 25,939.93
INVESTMENTS - FROM EARMARKED / ENDOWMENT FUNDS 6 20,086.28 15,462.73
INVESTMENT - OTHERS 7 13,744.66 5,396.24
CURRENT ASSETS, LOANS, ADVANCES ETC., 8 18,013.13 18,806.65
TOTAL 79,853.96 65,605.55 SIGNIFICANT ACCOUNTING POLICIES 17
NOTES ON ACCOUNTS 18
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
330 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Income & Expenditure Account for the Year Ended 31st March 2015
(Rs. In Lakh) PARTICULARS SCHEDULE 2014-15 2013-14 INCOME Income from Services 9 2,603.23 2,520.54
Grants / Subsidies 10 23,753.60 20,765.17
Fees / Subscriptions 11 370.90 482.68
Income From Government Securities/ Bonds 12 - -
Income from Investments 13 1,743.18 765.77
Other Income 14 880.78 930.14 TOTAL (A) 29,351.69 25,464.31 EXPENDITURE Establishment Expenses 15 28,202.39 18,298.81
Other Administrative Expenses etc., 16 6,797.95 5,769.12
Depreciation 5 3,436.98 2,942.57
Prior Period Depreciation 5 530.67 83.01 TOTAL (B) 38,967.99 27,093.50 Balance being excess of Income over Expenditure (A-B)
Transfer to Capital Account (9,616.29) (1,629.20) TOTAL 29,351.69 25,464.31 SIGNIFICANT ACCOUNTING POLICIES 17 … … NOTES ON ACCOUNTS 18 … …
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 331| Annual Report 2014-15 1.20 69.75 16.63 70.05 147.70 647.65 240.29 3236.73 6475.05 5,563.85 1,349.56 1,542.56 1,042.52 2013-14 14,553.11 32,392.19 10,797.40 (Rs. in Lakh) (Rs. ------1.54 61.07 1,863.98 6,789.86 2014-15 14,411.26 13,300.00 16,360.94 48,758.90 2014-15 PAYMENTS year
t he
Expenses a) Establishment Expenses made against funds for variousPayments projects Investments and Deposits made on FixedExpenditure Work- Assets & Capital in-Progress a) Purchase of Fixed Assets Aided Projects - Grants for Projects / Seminars / - Grants for Projects Aided Projects b) Administrative Expenses b) Administrative a) Out funds / endowment of earmarked Work-in-Progress Capital on b) Expenditure Symposiums / Workshops etc., SymposiumsWorkshops / b) Out funds - Short of own term investment in Banks in Progress Equipments on c) Expenditure d) Plan Contingencies Equipment e) Expenditure on Information Technology Information on e) Expenditure f & Development ) Research g) Software i) Electical Installation j) E-Journals Data Base Access k) Project Assets k) Project l) AC Plan l) AC for
I.
II. IV. III. t s - 9.32 0.26 2.24 4.89 27.22 10.00 928.00 400.00 4,100.00 1,503.67 2013-14 10,498.00 13,280.00 m en ay P - - - - and
14.07 40.00 863.00 400.00 5,100.00 2,807.95 2,215.85 2014-15 t s 12,017.00 14,322.00 eceip R RECEIPTS NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE SCIENCES, & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL a) Cash in hand ii) Non-Plan Opening Balances Grants Received b) Bank Balances Centre iii) De-Addiction iii) Capacity Building -Savings Accounts a) From Govt. of India Govt. a) From Other Sources c) From ii) Non-Plan i) Plan i) Plan b) From State Govt. b) From - Grants for Projects i) Aided Projects seminars / symposium / workshops, etc seminars / symposium / workshops, ii) Karnataka Society State Aids Prevention iii) KSAPS - 1611 iii) KSAPS iv) BCSF Blood Bank - 1608 v) KSAPS - NACO Contingency EID -1612 Contingency EID - NACO v) KSAPS vi) Other Grants
I. II.
332 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
3.65 0.84 18.30 22.65 18.49 407.44 83,010.61 2,807.95 505.78 681.00 189.15 14.07 17.19 79.20 26.55 41.55 22.88 0.14 0.76 6.78 - - - -
------1,04,655.64 2,657.69 446.59 3.82 -Sd- DIRECTOR TOTAL
Other Payments Centre a) De-addiction Closing Balances g) Royalty d) KSAPS (1612) d) KSAPS
b) DP & NR b) Bank Balances in Savings accounts c) KSAPS (BCSF) (1608) c) KSAPS a) Cash in hand e) Nursing College e) Nursing (Works) h) KST f ) IT (Contractors) Deduction i) New Contributory Pension Fund/GPF i) New Contributory Pension Bills (Non-Plan) j) AC k) Deposits
l)Others Funds m) Miscellaneous Payments n) Scheme ‘B’ Activities ‘B’ n) Scheme o) Human Brain Bank - Neuro Pathology o) Human Brain Bank - Neuro p) Convention Centre p) Convention q) Building & other Contructions Wokers’s Wokers’s q) Building & other Contructions Fund Welfare
VI.
VII.
1,075.99 83,010.61 46,649.28 2,475.20 326.79 611.34 470.95 21.37 16.05 26.06 19.91 188.01 73.70 83.85 30.27 89.36 57.61 26.76 0.86 3.64
-Sd- 1,502.24 REGISTRAR ------1,04,655.64 52,209.77 2,165.59 8,930.45 639.69 754.25 148.50 426.90 13.79 25.60 20.92 14.74 4.00 2.18 7.46 9.68 TOTAL Chief Accounts Officer Chief Accounts Deputy Financial & Advisor Income on Investments from Received Interest Other Income OtherAny Receipts a) Funds b) Deposits c) Investments other investments]
[Earmarked / Endowment Funds including Funds / Endowment [Earmarked m) Building & Other Construction workers Fund welfare On Bank Deposits a) Hospital Receipts d) AC Plan & Non-Plan d) AC b) General Donations c) Miscellaneous Receipts d) Interest on MCA on d) Interest e) Other Recoveries e) Interest on HBA on e) Interest f ) Fees g) Hostel Rent h) Water & Electricity Charges Water h) i) License Fees & Rent i) License Fees j) NHS k) DP & NR l) Convention Centre l) Convention
V. IV. VI. III.
-Sd-
National Institute of Mental Health and Neuro Sciences 333| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedule forming part of Balance Sheet as at 31st March 2015
SCHEDULE - 1 - CORPUS / CAPITAL FUND
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 Balance as at the beginning of the year 28,964.09 17,932.30 Add: Plan Capital Grants for 2014-15 (P.Y. 2013-14) 8,795.00 8,233.00 Add: GOK Plan Grants-Land - 50.00 Add: GOI Plan Grants-Equipment - 4,000.00 Add: Capital Grants De-Addiction centre for 2014-15 (P.Y. 2013-14) 293.00 378.00 Add: Other Capital Grants 40.00 - 38,092.09 30,593.30 Less: Balance of net expenditure transferred from the Income and Expenditure Account (9,616.29) (1,629.20) TOTAL 28,475.81 28,964.09
GRANTS FOR PROJECTS / SEMINARS / SYMPOSIUMS / WORKSHOPS / CSIR FELLOWSHIPS FOR THE YEAR 2014-15
SCHEDULE - 2 (Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Opening Balance 1. Balance of grants as on 1st April 2014 (P.Y. 1st April 2013) 870.18 3,919.13 2. Grants received during the year 1,893.82 1,503.67 3. Project Assets - (2,430.93) 4. Closed Projects transferred to Income (Net) - (563.66) TOTAL (A) 2,764.00 2,428.20 1.Net of Advances and Liabilities (Net Debit) 66.39 144.63 2.Expenditure during the year 1,448.74 1,413.39 TOTAL (B) 1,515.13 1,558.02 NET LIABILITY 1,248.86 870.18
-Sd- Deputy Financial Advisor & Chief Accounts Officer
334 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedule forming part of Balance Sheet as at 31st March 2015
SCHEDULE - 3 - EARMARKED / ENDOWMENT FUNDS
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 a) Opening Balance of the Funds 29,962.61 24,699.42
b) Additions to the Funds:
i) Donations / Grants 14,570.12 5,646.82
ii) Income from Investments made on account of funds 1,710.04 1,435.32
iii) Other additions - 16,280.16 - 7,082.14
Total (A+B) 46,242.77 31,781.56
c) Utilisation / Expenditure towards objectives of funds
i) Capital Expenditure - 50.00
ii) Revenue Expenditure 2,110.88 2,110.88 1,768.95 1,818.95 NET BALANCE AS AT THE YEAR END 44,131.88 29,962.61 Note: Interest income does not include interest from SB Accounts.
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 335| Annual Report 2014-15 - 791 33,353 86,727 36,000 60,650 43,386 42,000 59,324 1,16,199 1,64,575 7,11,131 3,04,003 3,08,872 3,86,764 1,72,043 2,89,080 2,04,059 12,95,201 58,28,053 25,65,865 14,47,426 17,81,394 31-03-2015 37,78,04,229 Balance as on 3,25,68,85,741 3,65,06,26,864 ------5,000 6,000 59,360 58,000 3,19,535 Payments 19,20,58,312 19,25,06,207 791 2015 Total 33,353 86,727 48,386 36,000 60,650 65,324 1,16,199 1,64,575 3,19,535 7,11,131 3,04,003 3,08,872 3,86,764 1,72,043 2,89,080 2,04,059 1,00,000 13,54,561 58,28,053 25,65,865 14,47,426 17,81,394 arch 37,78,04,229 3,44,89,44,053 3,84,31,33,071 M ------s t T FUNDS 4,212 6,796 5,266 31 769.00 28,291 11,772 16,676 t 1,07,258 Interest Interest Receipts 23,534.00 77,069.00 a
3,29,343.59 11,76,38,133 as
11,70,27,148.00 t ------hee 5,592 20,000 50,000 34,100 Grants/ S 3,19,535 3,71,850 1,96,200 Donations 37,78,04,229 1,02,20,06,213 1,40,08,07,719 - - alance 791 B 44,174 12,584 53,854 86,727 60,058 36,000 94,408 1,16,199 1,64,575 9,82,711 6,87,597 2,54,003 1,12,672 3,58,473 1,60,271 2,72,404 1,69,959 13,70,357 54,98,709 16,74,136 25,65,865 of
01-04-2014 t Balance as on 2,30,99,10,692 2,32,46,87,219 par
for m ing
M EN / ENDOW - 3 EAR M ARKED SCHEDULE chedule S PARTICULARS NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE SCIENCES, & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL Research Corpus Fund A/C CorpusResearch Fund Neuromuscular Research Fund Research Neuromuscular in Ayurvedic Medicine Centre Advanced Earned Leave Encashment Fund Fund Poor Vijayam Fund Bharani Endowment Jaya Research Pension & Gratuity Fund Pension Rajeswarai Fund Krishnamurthy Endowmnet Mrs. (DP&NR) Corpus Fund Fund Research Joint Conference Fund for Excellence Award Infosys Foundation R.F Disorders Disease and Movem’t Parkinson’s Fund Brain Cancer Research Carried Amount Forward Govindaswamy Murthy RaoGovindaswamy Memorial Fund Fund Epilepsy Research Fund Bio Research Human Brain Bank for Neuro Fund Murthy Endowment R.N. Dr. Subhadra Fund Rao Dayananda Endowment Fund Oration Prasad Dr.D.N. Fund Centre Information Neuroscience National Fund Mukund Memorial Award TMC Fund Research Wilsons Disease Corpus Fund Nerve InjuryPeripheral Fund Management and Research Genetics Fund Psychiatric Neuro
336 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15 - 3,500 17,000 45,632 60,776 2,21,882 7,33,990 8,04,913 1,07,995 1,41,737 1,25,826 2,81,547 5,11,147 2,51,706 5,00,000 7,16,105 3,88,994 7,02,471 3,13,909 5,10,456 96,16,322 13,10,553 58,91,604 25,00,000 10,53,333 29,40,979 19,95,942 15,30,611 3,44,53,178 3,05,72,459 1,23,94,619 65,18,62,702 3,65,06,26,864 4,41,31,88,753 ------9,476 7,000 5,764 20,000 4,20,336 5,58,396 3,57,661 22,99,828 40,40,606 1,08,63,159 19,25,06,207 21,10,88,433 7,000 17,000 60,776 23,500 510456 2,21,882 7,33,990 4,65,968 1,07,995 1,41,737 1,25,826 2,81,547 5,11,147 2,51,706 5,00,000 7,16,105 3,88,994 7,02,471 96,25,798 13,10,553 64,50,000 25,00,000 10,53,333 43,54,515 29,46,743 19,95,942 15,30,611 1,16,68,072 3,67,53,006 3,05,72,459 1,27,52,280 65,18,62,702 3,84,31,33,071 4,62,42,77,186 ------344 9,973 1,706 18,923 95,535 11,147 53,333 22,734 98,725 10,800 8,56,302 2,77,394 6,36,847 4,81,78,762 11,76,38,133 17,10,04,124 30,93,465 ------70,000 14,876 69,420 5,00,000 2,50,000 5,00,000 2,77,100 64,50,000 25,00,000 10,00,000 40,00,000 1,00,00,000 3,05,72,459 1,40,08,07,719 1,45,70,11,574 ------Deputy FinancialOfficer & Chief Accounts Advisor 7,000 17,000 38,575 60,776 23,500 510456 2,02,959 6,63,990 4,65,968 1,41,393 1,15,853 2,81,547 3,54,515 6,93,371 1,11,894 6,91,671 87,69,496 16,68,072 12,15,018 26,69,349 18,97,217 15,30,611 3,36,44,665 1,21,15,433 60,36,83,940 2,32,46,87,219 2,99,62,61,488 TOTAL Neurocon Neurosurgery Fund Neurocon Volunteers Lucture Fund Lucture Volunteers Acount Fund Sivarajan Award V. Professor Unit Child Psychiatry Relief Fund C.M’s Dr.R.N.Moorthy Mental Health & Neuro Sciences Mental Health & Neuro Dr.R.N.Moorthy Fund Research Schizophrenia and Depression OncologyNeuro Fund Research Student Association Nurses NIMHANS Sundaram Fund Clayton Brought Forward Amount Forward Brought Dr.Anisya Vasanth Meml. Oration Fund Meml. Vasanth Dr.Anisya Fund Memorial Award Vasanth Anisya Dr. Works for Development Corpus Fund for NMD Memorial Fund Vasanth Dr.Anisya Neurology Neurosurgery Corpus Fund Biological Fund Research Human Brain Bank for M. De-Addiction Orientation Programme Services Psychiatry Perinatal Fund / GNNR in RMC / KSM Fellowship Research Memorial PrizeGovindaswamy Fund VishalakshmammaV Fund Schizophrenia Research C Endowment and Music - Cognition M.F. Prasad D.N. Dr. - Projects Corpus Fund Research IllnessNational Assitance Fund Golden Jubilee Award Fund Neuroradiology Fund Golden Jubilee Award Department - Corpus of Psychiatry Fund Thirt) & C.F(Turuvekere Dept of Psychiatry Department of MH & SP Corpus Fund Neurology Golden Jubilee Fund Neurosurgery Corpus Fund Celebration Fund Day Independence Day/Republic (CD4/CD8) Fund KSAPS -Sd-
National Institute of Mental Health and Neuro Sciences 337| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedule forming part of Balance Sheet as at 31st March 2015
SCHEDULE - 4 - CURRENT LIABILITIES AND PROVISIONS
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 A. CURRENT LIABILITIES 1. Sundry Creditors & Deposits: a) EMD, SD, CMD 1,298.16 970.84 b) others 189.13 1,487.29 289.80 1,260.65
2. Statutory Liabilities: a) Overdue - - b) Others 93.76 93.76 120.05 120.05
3. Other Current Liabilities 1,616.16 1,616.16 1,756.75 1,756.75 TOTAL (A) 3,197.22 3,137.45 B. PROVISIONS - - TOTAL (B) - - TOTAL (A+B) 3,197.22 3,137.45
-Sd- Deputy Financial Advisor & Chief Accounts Officer
338 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
2.71 0.63 1.17
63.71 31.99 66.07 43.74 13.76 18.09 300.00 148.54 267.33 871.29 986.04 2,487.35 6,373.55 1,044.21 2,671.22 as at 13,219.76 23,268.71 25,939.93 22,282.67 As on Net BlockNet 31-03-2014 31-03-2014 (Rs. In lakh) (Rs.
3.60 0.79
71.71 31.99 76.22 36.02 76.23 46.55 58.30 300.00 161.45 384.80 294.89 2,602.36 7,863.94 1,013.33 1,025.80 2,800.19 as at 13,961.92 25,209.70 28,009.89 24,914.81 As on Net BlockNet 31-03-2015 31-03-2015
------
41.23 85.36 98.52 653.13 966.01 296.34 300.29 293.91 9,306.75 Upto 15,140.80 Total Total 27,182.35 27,182.35 31-03-2015 Depreciation 2015
------7.72 11.74 26.64 60.32 29.70 175.19 164.43 132.21 arch 1,266.82 2,092.87 3,967.65 3,967.65 2014-15 for the year M Depreciation s t ------29.48 77.64 31 68.82 477.94 801.58 164.13 273.65 233.59 t 8,039.92 2014 13,047.93 23,214.70 23,214.70 a
Upto 31-03- Depreciation Accumulated Accumulated T S as
------t 5.00 10.00 25.00 10.00 10.00 10.00 10.00 50.00 50.00 25.00 (%) hee Rate of S depreciation - 3.60 0.79 71.71 31.99 300.00 161.45 117.45 121.38 376.52 340.46 156.82 2,602.36 1,037.93 1,979.34 1,322.15 2015 23,268.67 23,004.74 2,800.19 54,897.35 52,097.16 alance Deputy FinancialOfficer & Chief Accounts Advisor as at 31-03- Total Assets Total B ------of
t 2,462.49 year during the Transferred par Deduction-s ASSE FIXED 5 : SCHEDULE
- - - 8.00 0.89 0.16 12.91 21.90 93.11 69.91 115.01 292.66 133.55 286.73 101.69 128.97 2,008.99 3,583.26 1,771.34 6,728.76 6,599.79 year Additions Additions during the for m ing
2.71 0.63 63.71 31.99 95.55 86.91 300.00 148.54 745.27 121.38 274.83 247.35 986.04 2,487.35 1,845.79 1,035.42 2,671.22 2014 21,259.68 19,421.48 48,168.59 45,497.37 Balance Opening as at 01-04- Gross BlockGross chedule S NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES , BANGALORE 560 029. BANGALORE , SCIENCES & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL
PARTICULARS ASSETS - PROJECTS Land WORK-IN-PROGRESS CAPITAL Equipment Leasehold Land Computers Buildings Furniture & fixtures Furniture Equipment Software Computers Library Books Furniture SUB-TOTAL (B) SUB-TOTAL Office Equipment GRAND TOTAL (A+B) TOTAL GRAND Electrical Insatallations Vehicles Books E Journals (Perpetual License) E Journals (Perpetual Software SUB-TOTAL (A) SUB-TOTAL -Sd-
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NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedule forming part of Balance Sheet as at 31st March 2015
SCHEDULE - 6 - INVESTMENTS FROM EARMARKED / ENDOWMENT FUNDS
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. In Government Securities 5,373.67 5,373.67 2. In Public Sector Banks 14,712.61 10,089.06 TOTAL 20,086.28 15,462.73
SCHEDULE - 7 - INVESTMENT - OTHERS
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Short term investments in Public Sector Banks 13,744.66 5,396.24 TOTAL 13,744.66 5,396.24
-Sd- Deputy Financial Advisor & Chief Accounts Officer
340 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedule forming part of Balance Sheet as at 31st March 2015
SCHEDULE - 8 - CURRENT ASSETS, LOANS, ADVANCES, ETC.,
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 A. CURRENT ASSETS 1. Inventories a) Stock of Consumables (Hospital & Others) 303.95 242.76 b) Stationery on hand 22.10 326.06 16.82 259.58 2. Sundry Debtors 98.55 59.20 3. Cash Balances in hand (Including cheques / drafts and mprest) 3.82 14.07 4. Bank Balances a) With Scheduled Banks 2,657.69 2,760.06 2,807.95 2,881.22 TOTAL (A) 3,086.11 3,140.80 B. LOANS, ADVANCES AND OTHER ASSETS 1. Loans a) Staff 25.00 16.53 b) Advance Receivables 210.18 200.67 c) Prepaid Expenses 225.29 196.30 d) Tax Deducted at Source (recoverable) 114.20 58.71 e) Margin Money Deposits (LC) 6,714.04 8,252.63 2. Advances to Supplies 5,267.36 12,556.06 5,909.73 14,634.58 3. Advances & Other amounts recoverable in cash or in kind or for value to be received a) Contingencies and Purchases (AC Non-Plan) 115.85 14.85 b) Due from Govt. of India - De-addiction - - c) Deposits 105.21 101.11 d) Receivable from General Provident Fund 188.69 4. Interest Receivable 1,961.21 2,370.96 915.31 1,031.27 TOTAL (B) 14,927.02 15,665.84
TOTAL (A+B) 18,013.13 18,806.65
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 341| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of Income & Expenditure for the year ended 31st March 2015
SCHEDULE - 9 - INCOME FROM SALES / SERVICES
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Income from Sales - DP & NR 30.46 26.76 2. Income from Services a) Hospital Services 2,572.77 2,603.23 2,493.79 2,520.54 TOTAL 2,603.23 2,520.54
SCHEDULE - 10 - GRANTS / SUBSIDIES (IRREVOCABLE GRANTS & SUBSIDIES RECEIVED)
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Central Government i) Plan 5,527.00 5,047.00 ii) Non-Plan 12,017.00 10,498.00 iii) De-Addiction 570.00 18,114.00 550.00 16,095.00 2. State Government i) Plan 400.00 400.00 ii) Non-Plan 5,100.00 4,100.00 iii) Capacity Building - 5,500.00 10.00 4,510.00 3. Government Agencies - KSAPS - Blood Bank i) BCSF - 1.40 ii) KSAPS - 1611 - 0.26 iii) KSAPS - 1612 - 4.89 4. ICMR Grants 139.60 139.60 153.62 160.17 TOTAL 23,753.60 20,765.17
-Sd- Deputy Financial Advisor & Chief Accounts Officer
342 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of Income & Expenditure for the year ended 31st March 2015
SCHEDULE - 11 - FEES / SUBSCRIPTIONS
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Fees (Academic Section) 370.90 482.21 2. Others - 0.47 TOTAL 370.90 482.68
SCHEDULE - 12 - INCOME FROM GOVERNMENT SECURITIES/ BONDS (Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Interest a) On Govt. Securities - - b) Other Bonds / Debentures - FDR with Banks - -
TOTAL - -
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 343| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of Income & Expenditure for the year ended 31st March 2015
SCHEDULE - 13 - INTEREST EARNED
(Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. On Savings Bank account: a) With Scheduled Banks 758.18 594.55 b) Accrued Interest (SB & FD) 985.00 1,743.18 166.72 761.27 2. On Loans: a) Employees / Staff - MCA - 0.86 b) Others - HBA - - 3.64 4.51 TOTAL 1,743.18 765.77
SCHEDULE - 14 - OTHER INCOME (Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Profit on Sale / disposal of Assets: a) Owned Assets - - b) Assets acquired out of grants, or received free of cost - - 2. Export Incentives realised - - 3. Fees for Miscellaneous Services a) Water & Electricity Charges 44.88 31.11 b) NHS 59.69 104.57 60.91 92.02 4. Miscellaneous Income a) Miscellaneous Receipts 304.82 385.90 b) Convention Centre 168.54 196.25 c) Project Overhead and Interest Income 70.50 59.88 d) Donation 7.45 16.05 e) Hostel Rent 213.60 172.37 f ) Tender Fee 11.30 776.21 7.67 838.12 TOTAL 880.78 930.14
-Sd- Deputy Financial Advisor & Chief Accounts Officer
344 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of Income & Expenditure for the year ended 31st March 2015
SCHEDULE - 15 - ESTABLISHMENT EXPENSES (Rs. In Lakh) PARTICULARS 2014-15 2013-14 1. Salaries & Wages (a) Non-Plan 11,333.11 6,741.46 (b) Plan 3,651.74 3,438.33 (c) Wages 343.23 15,328.09 356.37 10,536.16 2. Stipend and Residential benefits 2,192.31 1,880.97 3. Contribution to Other Fund (LS & PC) 6.25 5.34 4. Contribution to Pensioin Fund 10,220.06 5,392.08 5. Medical Treatment 455.68 12,874.30 484.25 7,762.65 TOTAL 28,202.39 18,298.81
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 345| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of Income & Expenditure for the year ended 31st March 2015
SCHEDULE - 16 - OTHER ADMINISTRATIVE EXPENSES, ETC., (Rs. In Lakh) PARTICULARS 2014-15 2013-14 1 Drugs 567.17 637.78 2 Diet Expenses 85.61 108.59 3 HNS 352.19 180.22 4 Linen 51.81 47.88 5 Gas & Oxygen 44.96 36.45 6 Chemicals 32.38 35.01 7 Animal House 9.97 8.08 8 Liveries 7.32 6.81 9 Lab Equipments & Apparatus 5.44 3.73 10 Electricity Charges 625.63 550.90 11 Water Charges 444.90 369.65 12 Repairs & Maintenance (Buildings, Garden & BME) 364.65 340.68 13 Rent, Rates and Taxes 7.51 7.74 14 Vehicles Running and Maintenance 27.62 25.02 15 Postage, Telephone and Communication Charges 35.90 33.27 16 Printing and Stationary 42.67 49.65 17 Travelling and Conveyance Expenses 122.40 92.89 18 Hospital Contingencies 1.08 0.73 19 Security and Cleaning 1,197.55 909.66 20 Miscellaneous Expenses 37.86 42.16 21 Office Contingencies 74.52 42.44 22 DP & NR 18.08 18.30 23 Equipment Contingencies 1,350.35 1,100.38 24 Drug De-Addiction Centre 539.27 520.93 25 Convention Centre 30.05 42.93 26 Books & Periodicals - 3.05 27 Fuel to Generator 33.93 44.64 28 E-Journals and Database 203.52 200.80 29 Information Technology 14.15 128.01 30 Furniture & Fixture - Maintenance 2.83 1.99 31 Research and Development 74.07 17.99 32 KSAPS A/c-1611 - 0.10 33 KSAPS A/c-1612 - 4.15
346 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
34 Professional Charges & Consultancy 17.23 19.39 35 Centre for Public health 86.82 0.68 36 Advertisement 27.30 1.62 37 Interventional Implants 129.60 118.31 38 Yoga Centre 16.04 - 39 Brain Bank 115.55 16.52 TOTAL 6,797.95 5,769.12
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 347| Annual Report 2014-15
INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of the accounts for the period ended 31st March 2015
SCHEDULE-17 –SIGNIFICANT ACCOUNTING POLICIES
1. SYSTEM AND METHOD OF ACCOUNTING:
The accounts have been prepared under the Historical cost Particulars Cut-Off-Date convention with Accrual system of accounting. Buildings 31/03/1994 Equipment & Tolls, Furniture and Vehicles 31/03/2004 2. The Provident Fund established for the benefits of the employees of NIMAHNS, Bangalore has been recognized Computers, Accessories and Software 31/03/2010 under Sub-Section (2) of Sec. 8 of the Provident Funds Act, Library Books, Journals & Database with 31/03/2012 1925 (19 of 1925) by the Govt. of India, Ministry of Finance Perpetual License vide Notification No. 4 (1)-E.V. 192 (I), dated 24th December 1992. 4. INVENTORY: Stock of Drugs, Chemicals, Linen, Stationery and other 3. FIXED ASSETS: Stores were taken at cost as per the Physical verification and Fixed assets are accounted at Historical cost of acquisition Certificates issued by Departmental Heads as on 31/03/2015. including inward freight, duties & taxes and incidental and direct expenses related to acquisition, installation and 5. INVESTMENTS: commissioning. All Investments are valued at cost. Fixed assets have been valued at cost less accumulated depreciation. Depreciation on Fixed assets is provided on 6. GOVERNMENT GRANTS: Straight Line Method at the following Rates. Grants received from Government of India and Government of Karnataka under Plan (General) and Non-Plan are treated as Percentage of Revenue unless they are Capital Grants. Plan Grants (Capital) Particulars Depreciation were utilized in acquiring Fixed Assets and are directly accounted under Capital Fund Account-Schedule 1. Capital Land 0% Grants of Rs. 50.70 crore remains unutilized as at the year Buildings 5% end and continues to remain as such for being utilized in the Equipment, Office Equipment, Electrical 10% ensuing year. Installations and Vehicles Computers, Peripherals and Software 25% 7. INVESTMENT OF EARMARKED/ENDOWMENT Library Books, E-Journals and Database 50% FUNDS AND INTEREST ACCRUED ON SUCH with Perpetual License INVETMENTS : Incomes earned on various Investments including Earmarked Depreciation is provided for the full year on addition of assets Investments have been recognized on accrual basis subject to acquired during the year. Assets created out of the Earmarked materiality conditions. Interest received on maturity are credited Funds, where the ownership of such assets vests with the to the concerned fund account, interest accrued on Earmarked/ Institute, were shown as Fixed Assets of the Institute. Endowment Fund are disclosed under ‘Claims Receivables’.
Fixed Assets which were acquired prior to the cut-off-date, as 8. RETIREMENT BENEFITS: tabled below, are fully depreciated. The Actuarial Valuation of pension liability and gratuity was carried out by SBI Life Insurance Company Limited. The
348 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
valuation certificate recommended a total service liability of 10. TAXATION: Rs.325.69 crores. An addition of Rs.102.20 crores was made The Institute is not liable to Income Tax as it is exempt under in the financial year. As against the total service liability of Se. 10(23)(c) of the Income Tax Act, 1961, hence no provision Rs.325.69 crores the Institute has Fund Deposits of Rs.133.71 has been made towards taxes. crores. 11. Govt. of India, Ministry of Home Affairs have accorded 9. Actuarial valuation of leave encashment liability has been permissions to the Institute to accept Foreign contributions obtained and provided for, during the year, amounting to Rs. vide their letter No. 11/2012/69(120)/1998-FCRA-III, dated 37.78 Crores. 1st October 2003 and Registered under Section 6(1)(a) of the Act with Registration Number: 094420795, under the category, Educational Social.
-Sd- -Sd- Deputy Financial Advisor & DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 349| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
Schedules forming part of the accounts for the period ended 31st march 2015
SCHEDULE-18 – NOTES ON ACCOUNTS FORMING PART OF INCOME AND EXPENDITURE ACCOUNT AND BALANCE SHEET
1. The Annual Accounts for the year 2014-15 is prepared on Rs.325.69 crores the Institute has Fund Deposits of Rs.133.71 Accrual basis. crores.
2. Liabilities are booked and recognized on receipt of bills of 8. Actuarial valuation of leave encashment liability has been materials/ equipment both in respect of Current and Other obtained and provided for, during the year, amounting to Rs. Liabilities. 37.78 Crores.
3. In respect of NIMHANS HEALTH SCHEME, for Ex- 9. employees of the Institute, the liability towards health care (i) Land (145 acres and 4480Sq.ft.) was allotted free of cost facility to be provided cannot be quantified and same is not by Government of Karnataka in the past. The land value material. (Rs. 71.71 lakh) shown under ‘Schedule 5- Fixed Assets’ represents incidental expenditure incurred in connection 4. Subscription to E-Journals and Database, the benefit of which with acquisition. is derived during the year of spending, has been treated as Revenue Expenditure and unexpired portion of subscription is (ii) During the year 2012-13 NIMHANS has been allotted treated as prepaid expenses. Land to the extent of 39 Acres and 38 Guntas at Kyalasanahalli, Bangalore, (30 Acres 38 Guntas is in 5. Current assets, Loans and Advances have a realizable value in possession and 9 Acres is in the process of transfer of the ordinary course of business, equal to the aggregate amount possession) by Government of Karnataka on lease basis. shown In the Balance Sheet. Two installments of the lease amount of Rs. 3 Crores (Fixed) for 30 years, payable @ Rs.50.00 lakh per year at 6 6. Schedules 1 to 18 are annexed to and form an integral part of yearly installments, has been paid so far. the Balance sheet as at 31st March 2015 and the Income and Expenditure Account for the Year ended that date. 10. An amount of Rs.201.17 Lakhs has been paid towards National Mental Health Program (Projects) in anticipation of 7. The Actuarial Valuation of pension liability and gratuity was reimbursement of the said amount from Government of India. carried out by SBI Life Insurance Company Limited. The valuation certificate recommended a total service liability of 11. An Amount of Rs.215.26 Lakhs has been received during the Rs.325.69 crores. An addition of Rs.102.20 crores was made financial year 2014-15 as Foreign contributions and accounted in the financial year. As against the total service liability of under FF A/c No.:54004656310.
-Sd- -Sd- Deputy Financial Advisor & DIRECTOR Chief Accounts Officer
350 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
Separate Audit Report of the Comptroller and Auditor General of India on the Accounts of the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore for the Year Ended 31 March 2015 and Reply of National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore
SEPARATE AUDIT REPORT OF THE COMPTROLLER REPLY OF NATIONAL INSTITUTE OF MENTAL HEALTH AND AUDITOR GENERAL OF INDIA ON THE ACCOUNTS AND NEURO SCIENCES (NIMHANS), BANGALORE OF THE NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES (NIMHANS), BANGALORE FOR THE YEAR ENDED 31 MARCH 2015
1. We have audited the attached Balance Sheet of the National Factual Institute of Mental Health and Neuro Sciences, Bangalore as at 31 March 2015 and the Income and Expenditure Account / Receipt & Payment Account for the year ended on that date under Section 20(1) of the Comptroller and Auditor General’s (Duties, Powers and Conditions of Service) Act, 1971. The audit of the Institute has been entrusted upto 2014-15. These financial statements are the responsibility of the Institute’s Management. Our responsibility is to express an opinion on these financial statements based on out Audit.
2. This Separate Audit Report contains the comments of the Factual Comptroller and Auditor General of India on the accounting treatment only with regard to classification, conformity with the best accounting practices, accounting standards and disclosure norms, etc. Audit observation on financial transactions with regard to compliance with the Law, Rules and Regulations (Propriety and Regularity) and efficiency-cum-performance, etc, if any are reported through Inspection Reports / Comptroller & Auditor General’s Audit Reports separately.
3. We have conducted our audit in accordance with auditing Factual standards generally accepted in India. These standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free from material mis-statements. An audit includes examining on a test basis, evidences supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of financial statements. We believe that our Audit provides a reasonable basis for our opinion.
4. Based on audit, we report that:
i. We have obtained all the information and explanations, which to the best of our knowledge and belief were necessary for the purpose of our audit.
National Institute of Mental Health and Neuro Sciences 351| Annual Report 2014-15
ii. The Balance Sheet and Income & Expenditure Account / Receipt & Payment Account dealt with by this report have been drawn up in the format approved by the Institute’s Board of Management and Finance Committee.
iii. In our opinion, proper books of accounts and other relevant records have been maintained by the Institute as required in so far as it appears from our examination of such books:
iv. We further report that:
A. REVISION OF ACCOUNTS A. REVISION OF ACCOUNTS The accounts have been revised on the basis of audit observation. The Revised Accounts have been submitted on 29.06.2015. The Facts Confirmed. effect of revision was that Assets & Liabilities decreased by Rs.445.83 lakh, Excess of Expenditure over Income increased by Rs.442.90 lakh.
B. GRANTSIN-AID B. GRANTSIN-AID The Institute receives Grants from both State and Central The Institute received grants of Rs.327.02 crore (out of which the Governments. Out of Grants of Rs.327.02 crore received during the contribution of Plan Fund from Ministry of Health & Family Welfare year, the Institute could utilize a sum of Rs.276.32 crore leaving a was Rs.87.95 crore under Capital). Out of which Rs.50.70 crore was balance of Rs.50.70 crore as unutilized grants as on 31st March 2015. earmarked for the purchase of a very costly machine called Intra Operative MR Suite. The purchase procedure for procurement of this equipment was initiated during December 2014. The first 2 bids were received but, then the same could not be processed as there were some technical problems. Again, Bids were called and 2 bids were qualified and one of them was L1. Since, the equipment is costly and beyond the financial powers of the Director, the matter was taken up with the second standing finance committee meeting held on 26th March 2015 at Nirman Bhavan, New Delhi. The SFC requested more information on the matter and permitted the institute to carry over the non-utilized funds to the next financial year 2015-16 with the provision that the amount should be utilized within first quarter ( June 2015). Accordingly the Institute resubmitted the proposal with the clarifications to the third SFC held on 2nd / 3rd June 2015 at Nirman Bhavan, New Delhi. After obtaining the necessary approvals the amount was utilized for procurement of Intra Operative MR Suite by opening necessary Letter of Credit during June 2015.
C. MANAGEMENT LETTER Deficiencies which have not been included in the Audit Report have been brought to the notice of the Director, NIMHANS, Bangalore through a management letter issued separately for remedial / corrective action. v. Subject to our observations in the preceding paragraphs, we report that the Balance Sheet and Income & Expenditure Account / Receipt & Payment Account dealt with by this report are in agreement with the books of accounts.
352 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
vi. In our opinion and to the best of our information and according to the explanations given to us, the said financial statements read with the Accounting policies and Notes on Accounts and subject to significant matters stated above and other matters stated in Annexure to this Audit Report, give a true and fair view in conformity with accounting principles generally accepted in India:
a. In so far as it relates to the Balance Sheet, of the state of affairs of the NIMHANS, Bangalore as at 31 March 2015: and
b. In so far as it relates to Income & Expenditure Account of the deficit for the year ended on that date.
For and on behalf of the C & AG of India Sd/- Sd/- Place: Bangalore PRINCIPAL DIRECTOR OF Place: Bangalore DIRECTOR, NIMHANS Date: 18 August 2015 AUDIT (CENTRAL) BANGALORE Date: 24 August 2015
National Institute of Mental Health and Neuro Sciences 353| Annual Report 2014-15
ANNEXURE
1. Adequacy of Internal Audit System 1. Adequacy of Internal Audit System
Internal Audit was conducted by the Ministry of Health and Family Factual Welfare, Government of India, New Delhi till December 2012. However, no audit has been conducted by them thereafter.
The Institute has one Internal Audit Officer and One Manager The Internal Audit team has been proactively helping with the appointed on contract basis who conducts audit and submits reports Departments to bring in the internal controls. Review of Inventory to the Director. During the year 2014-15, the Internal Auditor Management was done to bring in the quality of financial and has submitted only one report on the records of the General management information. Administration department. A Draft Internal Audit Manual is prepared on 20.06.2015, however the same is neither approved by The draft Internal Audit Manual has been prepared and submitted the Governing Council nor Standing Financial Committee. Internal for scrutiny and review by experts and the same will be submitted to Audit Department needs strengthening. the Special Finance Committee and Governing Body in due course for approval. 2. Adequacy of Internal Control System
The Internal Control System in the Institute is adequate.
3. System of Physical Verification of Fixed Assets 3. System of Physical Verification of Fixed Assets
The Fixed Assets have been verified by the management however the Factual. However, the task of physically verifying the Fixed Assets year-wise details of fixed assets are not maintained and compilation of year-wise Fixed Asset Register comprising all the Equipment, Buildings, Land, vis-à-vis with the available records since 4. System of Physical Verification of Inventory: the inception of the Institute is a laborious task and the work for the same has begun and it will be completed at the earliest. The Physical verification of Inventory has been carried out by the management
5. Regularity in payment of statutory dues:
The Institute is regular is making all the statutory dues.
Sd/- Sd/- PRINCIPAL DIRECTOR OF DIRECTOR, NIMHANS AUDIT (CENTRAL) BANGALORE
354 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
PROVIDENT FUND ACCOUNT
Balance sheet as at 31st March 2015
(Rs. In Lakh) CORPUS / CAPITAL FUND & LIABILITIES 2014-15 2013-14 CAPITAL FUND Opening Balance 4,494.25 4,020.42 Add: Receipts during the year 1,539.17 1,471.45 Add: Loan amount credit to Capital account 346.77 - 6,380.19 5,491.87 Less: Payments during the year 1,074.30 5,305.89 1,168.45 4,323.42
Excess of Income over Expenditure Add: Interest Accrued (PY) 206.54 206.54 170.83 170.83
CURRENT LIABILITIES Payable to Institute (P.Y. SBM) 188.69 188.69 - TOTAL 5,701.12 4,494.25 ASSETS INVESTMENTS - FROM EARMARKED / ENDOWMENT FUNDS (a) In Government Securities 1,685.00 1,685.00 (b) In Public Sector Banks 2,619.21 1,648.98 (c) In RBI Special Deposits 414.09 4,718.30 414.09 3,748.07
CURRENT ASSETS Cash at Canara Bank 429.49 317.46 Receivable From Institute (P.Y. SBM) - 257.89 Loan to Employees 346.77 - Interest on Investments Receivables 206.57 982.82 170.83 746.18 TOTAL 5,701.12 4,494.25
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 355| Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
PROVIDENT FUND ACCOUNT
Income & Expenditure Account for the year ended 31st March 2015
(Rs. In Lakh) INCOME 2014-15 2013-14 Interest Earned on Investments 186.92 226.11 Accrued Interest Earned on Investments 206.57 170.83
TOTAL (A) 393.49 396.94 EXPENDITURE Amount Credited to Employee’s Provident Fund Account 186.95 226.11
TOTAL (B) 186.95 226.11 Balance being excess of Income over Expenditure (A-B) Transfer to Capital Account 206.54 170.83 TOTAL 393.49 396.95
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
356 | National Institute of Mental Health and Neuro Sciences Annual Report 2014-15
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, BANGALORE
PROVIDENT FUND ACCOUNT
Receipts and Payments for the year 2014-15
(Rs. in Lakh) RECEIPTS 2014-15 2013-14 PAYMENTS 2014-15 2013-14 Opening Balances GPF Payments 1,074.30 1,160.45 (Payments of Advances, Withdrawls Bank Balance and i) 3803 - Canara Bank 317.46 264.44 Final Settlement) ii) State Bank of Mysore - 29.62 Interest Charges 0.03 - GPF Receipts 1,310.26 1,293.92 CPF Payment - 8.00 Repayments of loan amount 30.93 - Investments 399.00 111.04 CPF Receipts 11.05 8.97 Closing Balances (Subscription, Contribution & Interest) Cash Balance Interest Receipts 233.12 - 3803 - Canara Bank 429.49 317.46 TOTAL 1,902.81 1,596.95 TOTAL 1,902.81 1,596.95
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 357|
Homage
Sri. Pundaleeka Kumar CN, Office Assistant 17.07.2014 Sri. Stanley Prasanna Kumar, Supervisor Radiographer 23.09.2014 Sri. Muniraja B, Hospital Assistant 25.09.2014 Sri. Nagaraja, Hospital Assistant 12.12.2014 NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES P.B. No. 2900, BANGALORE - 560 029, India
Telephone: 091 - 080 - 2699 5000 / 2699 5100 / 2699 5200 Fax: 091 - 080 - 2656 4830 / 2656 2121 E mail: [email protected] / [email protected] Website: http://www.nimhans.ac.in Published by
Editor-in-Chief Dr. P. Satishchandra Director/Vice-Chancellor NIMHANS, Bangalore
Co-ordinators
Dr. N. Girish Additional Professor of Epidemiology Dr. Reeta Mani Associate Professor of Neurovirology Dr. Santosh Loganathan Associate Professor of Psychiatry Dr. Poornima Bhola Associate Professor of Clinical Psychology Dr. Vikas Associate Professor of Neurosurgery Dr. M. Jayaram Senior Professor and Officer In-Charge, Library & Information Centre and Publication Dept.
Credits Cover Page: English ‘Children’s Pavilion’, the old building which earlier served as an outpatient facility, has been modified retaining its heritage Mr. Prabhu Dev M, Assistant Editor architecture to house the NIMHANS Heritage Museum Mrs. Tejaswini A, Publication Dept. Mrs. Beereshwari, Publication Dept. Inside Back Cover: Mrs. T.D. Jayalakshmi, Publication Dept. Artwork by Praveen Arora (Art therapeutic activity in Psychiatric Mr. K. Manjunath, HBTR, Dept. of Neuropathology Rehabilitation Services, NIMHANS, Bengaluru)
Hindi Prof. Mahendra P. Sharma, Hindi Officer Design and Printing Mr. Shinde Pandurang, Hindi Cell Aditi Enterprises Mrs. A. Dhanalakshmi, Hindi Cell Bangalore - 560 023, Phone: 080-2310 7302 Mrs. M.K. Shamantha, Steno Gr. II E-mail: [email protected]
Ravi Hegde