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Facing the Digital Future of Pathology OCTOBER 2014 # 01 Upfront In Practice Profession Sitting Down With Ebola research gained How to minimize error in Where is the next generation Stephen Minger, Chief new insights but lost lives your molecular pathology lab of pathologists? Scientist, GE Healthcare 10 36 – 39 46 – 49 50 – 51 Facing the Digital Future of Pathology Are concerns around digital pathology technology based on fear or fact? 16 – 25 Nanozoomer_WSI_210x266_Layout 1 09/09/2014 08:02 Page 1 Slide Scanning Solutions for Whole Slide Imaging Hamamatsu has a NanoZoomer model to meet all your whole slide imaging needs, from a single slide or batch scans of up to 320 slides. Ultra-fast, simple creation of high resolution digital slides Rapid image sharing for remote consultation via the internet or LAN Easy duplication, storage, archiving, retrieval, image analysis and annotation A digital pathology resource for education, training, presentations and meetings No image degradation or photobleaching of labile fluorescent probes Optional fluorescence optics NanoZoomer-XR NanoZoomer 2.0-HT NanoZoomer 2.0-RS NanoZoomer SQ Ultra-fast scanning of up to 320, 76mm Ultra-fast scanning of up to 210, Fast scanning of up to 6, 76mm x 26mm New affordable desktop single x 26mm slides 76mm x 26mm slides slides or 2, 76mm x 52mm slides with slide scanner optional slide loader www.nanozoomer.com Online this Month Guest List Website “If your name’s not down, you’re not coming in!” The website really comes alive when you register. You can access all the printed content, plus find online exclusives and sign up for newsletters and alerts with further benefits over The Pathologist website acts as a hub for both our content the next few months! thepathologist.com/login and our community. Visitors can access all articles, engage with multimedia elements and interact through comments. Regular electronic newsletters and social media drive further activity on the website. Social Media Find more from ThePathologist. Connect and interact Everywhere You Go online through Facebook, LinkedIn, Google Plus, our YouTube channel and via Twitter (@pathologistmag) Content at 30,000 feet. The Pathologist iPad app is now available to download at the Apple App Store. Offering the ability to download and read content offline, it's easy to take The Pathologist wherever you go. The Dotted Line ....................................... To download the app and for updates on the upcoming To guarantee your next copy of The Pathologist, sign up Android version, visit: online and confirm your print subscription. And please feel thepathologist.com/app free to pass this invitation onto colleagues. Subscription is qualified but free: thepathologist.com/login Contents 46 50 03 Online This Month Upfront 10 10 Tracing the Ebola Genome 07 Editorial Welcome to The Pathologist 11 FDA Crackdown on Labs By Fedra Pavlou Feature 12 Unscrambling Schizophrenia 16 Facing the Digital Future 08 Contributors 13 Targeting Postpartum Depression of Pathology Digital Pathology is here to 14 The Survival Artists stay, but while some pathologists On The Cover have embraced it, others cite OCTOBER 2014 # 01 15 To Use pCR, We Must First ongoing issues such as Upfront In Practice Profession Sitting Down With Tracing the Ebola genome Best practice guide for Where is the next generation Stephen Minger, Chief molecular pathology labs of pathologists? Scientist, GE Healthcare 11 36 46 – 49 50 – 51 Digital pathology begins to take root Define It standardization, storage, workflow Facing the Digital Future of Pathology Are concerns around digital pathology technology based on fear or fact? 16 – 25 in traditional pathology and security. We discuss the facts with the users and vendors. ISSUE 01 - OCTOBER 2014 Editor - Fedra Pavlou [email protected] Associate Editor - Roisin McGuigan [email protected] Associate Editor - Stephanie Sutton [email protected] Senior Designer - Marc Bird [email protected] Chief Executive Officer - Andy Davies [email protected] Chief Operating Officer - Tracey Peers [email protected] Publisher - Mark Goodrich [email protected] Audience Development Manager - Tracey Nicholls 36 [email protected] Digital Content Manager - David Roberts NextGen [email protected] 28 Human Proteome Maps - 40 Lab Turnaround Time Study Sets Traffic and Administration Manager - Claire Lally Two Perspectives Alarm Bells Ringing [email protected] Bernhard Kuster describes his Enrique Rodríguez-Borja Mac Operator Web/Print - Peter Bartley ongoing work to map the human recounts his experience of [email protected] proteome, including some surprising measuring turnaround time both findings, while Michael Tress adds inside and outside his laboratory. Social Media / Analytics - Stephen Mayers a question mark over accuracy. Do you know when clinicians [email protected] consult your reports? 31 Operating Within Published by Molecular Margins Texere Publishing Limited, Booths Hall, Sandro Santagata and Booths Park, Chelford Road, Knutsford, Cheshire, Nathalie Agar believe DESI Profession WA16 8GS, UK MS has the potential to transform intraoperative tissue analysis, and 46 Where is the Next Generation clinical mass spec has already of Pathologists? General enquiries: attracted industry attention. Why are fewer medical students www.texerepublishing.com [email protected] choosing a career in pathology? +44 (0) 1565 752883 Suzy Lishman tells us what she [email protected] thinks will help buck the trend. In Practice Distribution: 36 Minimize Errors, Report The Pathologist is distributed worldwide through 10,000 printed copies to a targeted European with Accuracy Sitting Down With mailing list of industry professionals and 22,500 Ian Cree talks best practice electronic copies worldwide. guidelines in the molecular 50 Stephen Minger, Chief Scientist, ISSN 2055-8228 pathology lab, including reflex Cellular Sciences, Life Sciences, testing, common blunders and the GE Healthcare, London, UK. need for clarity in increasingly complex molecular reports for patients with cancer. DIGITALDIGITAL PATPATHOLOGYHOLOGY CONGRESSCONGRESS 4-5 December 2014 London, UK London Heathrow Marriott Hotel UNDERSTANDING AND UTILIZING DIGITAL PATHOLOGY AS A TOOL FOR ADVANCING PATHOLOGY PRACTICE AND ENABLING ENHANCED PATIENT CARE KEYNOTE SPEAKERS JO MARTIN, LIRON PANTANOWITZ, MARCIAL GARCIA ROJO, National Clinical Director of Associate Professor of Pathology & Head of Pathology Pathology NHS England, Biomedical Informatics, Director of the Department, Hospital Professor of Pathology, Queen Pathology Informatics Fellowship Program de Jerez de la Frontera, Mary University of London, and Associate Director of the Pathology Cádiz, Spain Director of Academic Health Informatics Division at the University of Sciences, Barts Health NHS Trust Pittsburgh Medical Center, USA DAY 1 DAY 2 Stream 1: Digital Pathology - Strategy and Technology Stream 1: Digital Image Analysis Stream 2: Pathology Informatics Stream 2: Digital Pathology Applications and Research Case Studies Utilizing Digital Pathology GOLD SPONSOR: SILVER SPONSORS: READER DISCOUNT Save 10% with Discount Code: SPONSORS: DPR/10 Tel: +44 1865 849 841 Email: [email protected] www.globalengage.co.uk/digital-pathology.html Digital Pathology Congress Advert.indd 1 22/09/2014 11:37:01 Welcome to The Pathologist Editorial From academic to clinical pathology, microbiology to molecular pathology, we promise to report on the issues and innovations at the heart of your field. elcome to the first issue of The Pathologist. What is this new publication all about? Well, our aim is to provide you with insight into the latest research and technological breakthroughs that affect – or will affect – your work in the field of pathology. WFor example, our first issue focuses on a topic that has divided the community – digital pathology (see page 16). While it’s not a new phenomenon, opinions vary vastly. The general consensus: if you’re not using it, you probably will be in the next few years. And though cynicism remains, the digital pathology seminar held at this year’s European Congress of Pathology (ECP) was packed to the rafters and was followed by an extremely energetic discussion. Evidently, people are interested, but there are also concerns; cost, standardization, training, and privacy issues, for example, all need to be addressed. A senior manager of a company that’s actively involved in digital solutions admitted to me recently that pathologists will only adopt the technology if industry can demonstrate that there is a clear need. Despite opinions being divided, Berlin’s Manfred Dietl made an interesting point in his presentation at ECP: you cannot afford to ignore it. After all, bad press surrounding false diagnoses and inaccurate reports, in particular for patients with cancer, have publicly emphasized areas that need to be addressed. Although Dietl accepted there are downsides to integrating digital technology, the upsides – increased need for quantification, reduced variability and increased objectivity – are far greater. I hope such hot topics will fully engage each and every one of you. If you want to contribute to the ongoing debate on digital pathology, please drop me an email. In addition to offering in depth or high level coverage of topics that are destined to have a wide and great impact, we want to focus our editorial
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