Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

This file has one row for every form 123 recording outcome(s). A participant may have more than one of these forms. Only the first occurrence of each outcome is counted, e.g. Limiting the file to rows where BKANKLE=1 will find a single row for each participant with an ankle fracture outcome.

*SUBJID WHI dbGaP Subject ID Col#1

ASCSOURCE Ascertainment Source Col#2

Value Description N % 1 Local Form 123 2,077 81.5 2 Central Form 123 471 18.5

*BKANKLE Ankle Fracture Col#3

Value Description N % 1 Yes 296 11.6 Missing 2,252 88.4 Usage Notes: Ankle Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Ankle Fracture is not counted if pathologic.

*BKCARPAL Carpal Fracture Col#4

Carpal bones in wrist

Value Description N % 1 Yes 42 1.6 Missing 2,506 98.4 Usage Notes: Carpal Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Carpal Fracture is not counted if pathologic.

*BKCLAVICLE Clavical Fracture Col#5

Value Description N % 1 Yes 29 1.1 Missing 2,519 98.9 Usage Notes: Clavical Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Clavical Fracture is not counted if pathologic.

*BKELBOWNOS Elbow NOS Fracture Col#6

Elbow, not otherwise specified

Value Description N % 1 Yes 5 0.2 Missing 2,543 99.8 Usage Notes: Elbow NOS Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Elbow NOS Fracture is not counted if pathologic.

February 07, 2013 Page 1 of 6

Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

*BKHIP Col#7

Value Description N % 1 Yes 471 18.5 Missing 2,077 81.5 Usage Notes: This file contains outcomes collected through Ext1.

*BKLELBOW Lower End of Col#8

Value Description N % 1 Yes 25 1.0 Missing 2,523 99.0 Usage Notes: Lower End of Humerus Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Lower End of Humerus Fracture is not counted if pathologic.

*BKHAND Metacarpal Fracture Col#9

Value Description N % 1 Yes 60 2.4 Missing 2,488 97.6 Usage Notes: Metacarpal Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Metacarpal Fracture is not counted if pathologic.

*BKPATELLA Col#10

Value Description N % 1 Yes 91 3.6 Missing 2,457 96.4 Usage Notes: Patella Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Patella Fracture is not counted if pathologic.

*BKPELVIS Fracture Col#11

Value Description N % 1 Yes 76 3.0 Missing 2,472 97.0 Usage Notes: Pelvis Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Pelvis Fracture is not counted if pathologic.

*BKLARM or Col#12

Value Description N % 1 Yes 455 17.9 Missing 2,093 82.1 Usage Notes: Radius or Ulna Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Radius or Ulna Fracture is not counted if pathologic.

*BKCOCCYX or Fracture Col#13

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Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

Value Description N % 1 Yes 25 1.0 Missing 2,523 99.0 Usage Notes: Sacrum or Coccyx Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Sacrum or Coccyx Fracture is not counted if pathologic.

*BKSCAPULA Scapula Fracture Col#14

Value Description N % 1 Yes 9 0.4 Missing 2,539 99.6 Usage Notes: Scapula Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Scapula Fracture is not counted if pathologic.

*BKUPPERLEG Shaft of Femur Fracture Col#15

Value Description N % 1 Yes 26 1.0 Missing 2,522 99.0 Usage Notes: Shaft of Femur Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Femur Fracture is not counted if pathologic.

*BKOHUMERUS Shaft of Humerus Fracture Col#16

Fracture of humerus, shaft or unspecified part

Value Description N % 1 Yes 21 0.8 Missing 2,527 99.2 Usage Notes: Shaft of Humerus Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Shaft of Humerus Fracture is not counted if pathologic.

*BKFOOT Tarsal or Metatarsal Fracture Col#17

Value Description N % 1 Yes 277 10.9 Missing 2,271 89.1 Usage Notes: Tarsal or Metatarsal Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tarsal or Metatarsal Fracture is not counted if pathologic.

*BKTIBIAFIBULA Tibia or Fibula Fracture Col#18

Value Description N % 1 Yes 139 5.5 Missing 2,409 94.5 Usage Notes: Tibia or Fibula Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibia or Fibula Fracture is not counted if pathologic.

*BKTIBIAL Tibial Plateau Fracture Col#19 February 07, 2013 Page 3 of 6

Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

Value Description N % 1 Yes 36 1.4 Missing 2,512 98.6 Usage Notes: Tibial Plateau Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Tibial Plateau Fracture is not counted if pathologic.

*BKUHUMERUS Upper End of Humerus Fracture Col#20

Value Description N % 1 Yes 205 8.0 Missing 2,343 92.0 Usage Notes: Upper End of Humerus Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper End of Humerus Fracture is not counted if pathologic.

*BKUELBOW Upper Radius/Ulna Fracture Col#21

Value Description N % 1 Yes 89 3.5 Missing 2,459 96.5 Usage Notes: Upper Radius/Ulna Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Upper Radius/Ulna Fracture is not counted if pathologic.

*BKSPINE Vertebral Fracture Col#22

Value Description N % 1 Yes 171 6.7 Missing 2,377 93.3 Usage Notes: Defined as the first occurence of Lumbar Spine Fracture or Thoracic Spine Fracture. Vertebral Fracture was adjudicated during the core WHI study. It was adjudicated at all clinics for CT participants, but only adjudicated at the bone density clinics for OS participants. Does not include cervical fractures.

HIPFSITE Fracture site (hip) Col#23

Value Description N % 1 Neck of femur 307 12.0 2 Intertrochanteric fracture 139 5.5 3 Greater trochanter 13 0.5 4 Unspecified part of proximal femur 12 0.5 Missing 2,077 81.5

HIPFSIDE Side of hip fracture Col#24

Value Description N % 1 Right 227 8.9 2 Left 243 9.5 3 Both sides 1 0.0 9 Unknown 0 0.0 Missing 2,077 81.5

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Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

HIPFBASE Hip Fracture Based On Col#25

Value Description N % 1 Radiology & discharge summary dx new hip 378 14.8 fracture 2 Radiology dx of hip fx, but not on discharge 31 1.2 summary 3 Discharge, equiv. xray, unequiv. scan/MRI 10 0.4 dx hip fx 4 Hip fracture dx in discharge summary, but 52 2.0 no radiology rprt 5 Uncertain radiology report of hip fracture 0 0.0 without add. doc Missing 2,077 81.5 Usage Notes: Not collected on early versions of F123. Value 5 was not collected after WHI closeout.

HIPFPATH (of hip) Col#26

Pathologic hip fracture: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone or joint prostheses, or surgical manipulation.Osteoporotic fracture is not considered a pathologic fracture.) Value Description N % 0 No 444 17.4 1 Yes 16 0.6 2 Possible 11 0.4 Missing 2,077 81.5

FRACSIDE F123 Side of fracture (non hip) Col#27

Value Description N % 1 Right 881 34.6 2 Left 951 37.3 3 Both sides 18 0.7 4 Not applicable (e.g. tailbone) 176 6.9 9 Unknown 18 0.7 Missing 504 19.8 Usage Notes: Not collected after WHI closeout.

FRACCONF F123 Fracture confirmed as (non hip) Col#28

Value Description N % 1 Non vertebal: Radiology report new fracture 1,465 57.5 2 Non vertebal: Radiology report healing 47 1.8 fracture 3 Non vertebal: Non radiology report 408 16.0 new/healing fracture 4 Non vertebal: Init. rad.report equiv., subs 21 0.8 report dx fract. 5 Vertebal: Radiology report based on 80 3.1 AP/lateral thoracolumbar 6 Vertebal: Radiology rprt not based 35 1.4 AP/lateral thoracolumbar Missing 492 19.3 Usage Notes: Not collected after WHI closeout.

FRACPATH F123 Pathologic fracture (non hip) Col#29

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Fracture Outcome Details (Form 123, CaD ppts) through Extension 1

File Name Population Data Collected 1 row per Rows outc_fracture_cad_dbgap_rel4.dat WHI dbGaP Cohort: Main, Ext1 Outcome Form 2,548 CaD

Pathologic fracture other than hip: (Fracture resulting from bone tumors or cysts, Paget’s disease, bone and joint prostheses, or surgical manipulation. Osteoporotic fracture is not considered a pathologic fracture.) Value Description N % 0 No 1,982 77.8 1 Yes 6 0.2 2 Possible 12 0.5 Missing 548 21.5 Usage Notes: Not collected after WHI closeout. Non vertebral fractures are not counted if they are pathologic.

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