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TEDX List of Potential Endocrine Disruptors 2011.10.10 TEDX List of Potential Endocrine Disruptors 2011.10.10 CHEMICAL NAME ALTERNATIVE CAS # TEDX# YEAR CITATION DATE NAME(S) ADDED (YYYYMMD D) 4-nitrophenol p-nitrophenol 100-02-7 H21269 2006 Li C, Taneda S, Suzuki AK, Furuta C, Watanabe G, Taya K. 2006. Estrogenic 20110505 and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles. Toxicol Appl Pharmacol 217(1):1-6. 4-nitrophenol p-nitrophenol 100-02-7 H23999 2009 Li X, Li C, Suzuki AK, Taneda S, Watanabe G, Taya K. 2009. 4-Nitrophenol 20110505 isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats. Endocrine 36(1):98-102. 4-nitrophenol p-nitrophenol 100-02-7 W14938 2010 Mi Y, Zhang C, Li CM, Taneda S, Watanabe G, Suzuki AK, Taya K. 2010. 20110505 Protective effect of quercetin on the reproductive toxicity of 4-nitrophenol in diesel exhaust particles on male embryonic chickens. J Reprod Dev 56(2): 195-199. dibutyltin DBT; di-n-butyltin 1002-53-5 H16880 2005 Atanasov AG, Nashev LG, Tan S, Baker ME, Odermatt A. 2005. Organotins 20110616 disrupt the 11<beta>-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect 113(11):1600-1606. 4-(imidazol-1-yl)phenol 10041-02-8 W08346 2000 Schultz TW, Sinks GD, Cronin MTD. 2000. Effect of substituent size and 20110505 dimensionality on potency of phenolic xenoestrogens evaluated with a recombinant yeast assay. Environ Toxicol Chem 19(11):2637-2642. styrene 100-42-5 H25131 1984 Mutti A, Falzoi M, Romanelli A, Franchini I. 1984. Regional alterations of brain 20110505 catecholamines by styrene exposure in rabbits. Arch Toxicol 55(3):173-177. styrene 100-42-5 H08720 1985 Zaidi NF, Agrawal AK, Srivastava SP, Seth PK. 1985. Effect of gestational and 20110505 neonatal styrene exposure on dopamine receptors. Neurobehavioral Toxicology & Teratology 7(1):23-28. styrene 100-42-5 H10535 2000 Takao T, Nanamiya W, Nazerloo HP, Asaba K, Hashimoto K. 2000. Possible 20110505 reproductive toxicity of styrene in peripubertal male mice. Endocr J 47(3): 343-347. boric acid 10043-35-3 H07687 1992 Linder RE, Strader LF, Slott VL, Suarez JD. 1992. Endpoints of 20110505 spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants. Reprod Toxicol 6(6):491-505. chlorine dioxide 10049-04-4 H06264 1982 Bercz JP, Jones L, Garner L, Murray D, Ludwig A, Boston J. 1982. Subchronic 20110505 toxicity of chlorine dioxide and related compounds in drinking water in the nonhuman primate. Environ Health Perspect 46:47-55. chlorine dioxide 10049-04-4 H06307 1986 Revis NW, McCauley P, Bull R, Holdsworth G. 1986. Relationship of drinking 20110505 water disinfectants to plasma cholesterol and thyroid hormone levels in experimental studies. Proceedings of the National Academy of Sciences USA 83(5):1485-1489. chlorine dioxide 10049-04-4 H00179 1986 Harrington RM, Shertzer HG, Bercz JP. 1986. Effects of chlorine dioxide on 20110505 thyroid function in the African green monkey and the rat. J Toxicol Environ Health 19(2):235-242. 1 TEDX List of Potential Endocrine Disruptors 2011.10.10 4,4'-dihydroxy-2,3,5,6- 4,4'-diOH-PCB-65; 100702-98-5 H00776 1988 Korach KS, Sarver P, Chae K, McLachlan JA, McKinney JD. 1988. Estrogen 20110505 tetrachlorobiphenyl 2,3,5,6'- receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally tetrachloro-4,4'- restricted structural probes. Mol Pharmacol 33(1):120-126. biphenyldiol atrazine-desisopropyl 1007-28-9 H07252 1996 Tran DQ, Kow KY, McLachlan JA, Arnold SF. 1996. The inhibition of estrogen 20110505 (atrazine metabolite) receptor-mediated responses by chloro-s-triazine-derived compounds is dependent on estradiol concentration in yeast. Biochemical & Biophysical Research Communications 227(1):140-146. atrazine-desisopropyl 1007-28-9 H11792 2001 Sanderson JT, Letcher RJ, Heneweer M, Giesy JP, van den Berg M. 2001. 20110505 (atrazine metabolite) Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ Health Perspect 109(10):1027-1031. lead nitrate 10099-74-8 W05057 1987 Katti SR, Sathyanesan AG. 1987. Lead nitrate induced changes in the thyroid 20110616 physiology of the catfish Clarias batrachus (L.). Ecotoxicology & Environmental Safety 13(1):1-6. cadmium chloride 10108-64-2 H06396 1989 Bhattacharya T, Bhattacharya S, Ray AK, Dey S. 1989. Influence of industrial 20110505 pollutants on thyroid function in Channa punctatus (Bloch). Indian J Exp Biol 27(1):65-68. cadmium chloride 10108-64-2 H22655 1975 Nordberg GF. 1975. Effects on long-term cadmium exposure on the seminal 20110616 vesicles of mice. J Reprod Fertil 45(1):165-167. cadmium chloride 10108-64-2 H00704 1988 Shrivastava VK, Sathyanesan AG. 1988. Effect of cadmium chloride on thyroid 20110616 activity of the female Indian Palmsquirrel, Funambulus pennati (Wroughton). Bull Environ Contam Toxicol 40(2):268-272. cadmium chloride 10108-64-2 H09970 2000 Stoica A, Katzenellenbogen BS, Martin MB. 2000. Activation of estrogen 20110616 receptor-alpha by the heavy metal cadmium. Mol Endocrinol 14(4):545-553. cadmium chloride 10108-64-2 H13501 2003 Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, 20110616 Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB. 2003. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 9(8):1081-108 cadmium chloride 10108-64-2 H23321 1990 Simons SS Jr, Chakraborti PK, Cavanaugh AH. 1990. Arsenite and 20110705 cadmium(II) as probes of glucocorticoid receptor structure and function. J Biol Chem 265(4):1938-1945. diphenyltin DPT 1011-95-6 H16880 2005 Atanasov AG, Nashev LG, Tan S, Baker ME, Odermatt A. 2005. Organotins 20110616 disrupt the 11<beta>-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids. Environ Health Perspect 113(11):1600-1606. triclocarban TCC; 3,4,4'- 101-20-2 H22146 2008 Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley 20110505 trichlorocarbanilide B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. 2008. In vitro ; N-(chloro)-N'- biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in (3,4-dichloro)- bioassay screens: Receptor-based bioassay screens. Environ Health Perspect phenylurea 116(9):1203-1210. (CDCPU) 2 TEDX List of Potential Endocrine Disruptors 2011.10.10 chlorpropham 101-21-3 W14888 2009 Orton F, Lutz I, Kloas W, Routledge EJ. 2009. Endocrine disrupting effects of 20110505 herbicides and pentachlorophenol: in vitro and in vivo evidence. Environ Sci Technol 43(6):2144-2150. chlorpropham 101-21-3 H25128 2011 Orton F, Rosivatz E, Scholze M, Kortenkamp A. 2011. Widely used pesticides 20111007 with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect 119(6):794-800. 4-benzylphenol p-benzylphenol; 101-53-1 H11750 2001 Hashimoto Y, Moriguchi Y, Oshima H, Kawaguchi M, Miyazaki K, Nakamura 20110505 benzophenone-7 M. 2001. Measurement of estrogenic activity of chemicals for the development (BP-7); 4- of new dental polymers. Toxicol in Vitro 15(4-5):421-425. (phenylmethyl)phe nol; phenyl-4- hydroxyphenylmet hane; 1- (phenyl)-1-(p- hydroxyphenyl)met hane 4-benzylphenol p-benzylphenol; 101-53-1 H15217 2003 Kitamura S, Sanoh S, Kohta R, Suzuki T, Sugihara K, Fujimoto N, Ohta S. 20110505 benzophenone-7 2003. Metabolic activation of proestrogenic diphenyl and related compounds (BP-7); 4- by rat liver microsomes. Journal of Health Science 49(4):298-310. (phenylmethyl)phe nol; phenyl-4- hydroxyphenylmet hane; 1- (phenyl)-1-(p- hydroxyphenyl)met hane 4-benzylphenol p-benzylphenol; 101-53-1 H16357 2003 Yamasaki K, Takeyoshi M, Sawaki M, Imatanaka N, Shinoda K, Takatsuki M. 20110505 benzophenone-7 2003. Immature rat uterotrophic assay of 18 chemicals and Hershberger assay (BP-7); 4- of 30 chemicals. Toxicology 183(1-3):93-115. (phenylmethyl)phe nol; phenyl-4- hydroxyphenylmet hane; 1- (phenyl)-1-(p- hydroxyphenyl)met hane 3 TEDX List of Potential Endocrine Disruptors 2011.10.10 4-benzylphenol p-benzylphenol; 101-53-1 H18228 2003 Yamasaki K, Takeyoshi M, Yakabe Y, Sawaki M, Takatsuki M. 2003. 20110505 benzophenone-7 Comparison of the reporter gene assay for ERalpha antagonists with the (BP-7); 4- immature rat uterotrophic assay of 10 chemicals. Toxicol Lett 142(1-2): (phenylmethyl)phe 119-131. nol; phenyl-4- hydroxyphenylmet hane; 1- (phenyl)-1-(p- hydroxyphenyl)met hane 4-benzylphenol p-benzylphenol; 101-53-1 H22440 2008 Akahori Y, Nakai M, Yamasaki K, Takatsuki M, Shimohigashi Y, Ohtaki M. 20110505 benzophenone-7 2008. Relationship between the results of in vitro receptor binding assay to (BP-7); 4- human estrogen receptor alpha and in vivo uterotrophic assay: Comparative (phenylmethyl)phe study with 65 selected chemicals. Toxicol in Vitro 22(1):225-231. nol; phenyl-4- hydroxyphenylmet hane; 1- (phenyl)-1-(p- hydroxyphenyl)met hane heptachlor epoxide 1024-57-3 H01345 1985 Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific 20110505 binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102. heptachlor epoxide 1024-57-3 H13732 2004 Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening 20110505 for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531. endosulfan sulfate 1031-07-8 W04613 1996 Vonier PM, Crain DA, McLachlan JA, Guillette LJ Jr., Arnold SF. 1996. 20110505 Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect 104(12):1318-1322. endosulfan sulfate 1031-07-8 H13035 1997 Jin L, Tran DQ, Ide CF, McLachlan JA, Arnold SF.
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