bioRxiv preprint doi: https://doi.org/10.1101/2020.02.26.939405; this version posted February 26, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Heteroplasmy variability in individuals with biparentally inherited mitochondrial DNA Jesse Slonea,¶, Weiwei Zoua,b,¶, Shiyu Luoa,#, Eric S Schmittc,d, Stella Maris Chend, Xinjian Wanga, Jenice Browna, Meghan Bromwella, Yin-Hsiu Chiene, Wuh-Liang Hwue, Pi-Chuan Fanf, Ni-Chung Leee, Lee-Jun Wongc, Jinglan Zhangc,&, and Taosheng Huanga,&,* a Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA b Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China c Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA d Baylor Genetics, Houston, TX, 77030 e Department of Pediatrics and Medical Genetics, National Taiwan University Hospital, Taipei 10041, Taiwan f Department of Pediatrics, National Taiwan University Hospital, Taipei 10041, Taiwan * To whom correspondence should be addressed. E-mail:
[email protected] ¶ These authors contributed equally to this study. & These authors contributed equally to this study. # Current affiliation: Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.02.26.939405; this version posted February 26, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.