SUPPLEMENTARY DATA Supplementary Figure 1.Disposition
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SUPPLEMENTARY DATA Supplementary Figure 1.Disposition diagram showing the number of relatives followed according to number of autoantibodies and the number of events. a Comprising 151 single autoAb+ relatives at first sampling and 116 who seroconverted to single autoAb-positivity. b Comprising 147 multiple autoAb+ relatives at first sampling and 47 relatives who seroconverted from autoAb-negativity directly to multiple autoAb-positivity. cOne relative who remained single autoAb+ and developed type 1 diabetes was excluded from this analysis, because HLA class I alleles could not be determined. In four relatives multiple autoAb positivity was first detected at diagnosis and were therefore excluded from the second phase of the analysis (ie progression from multiple autoAb-positivity to type 1 diabetes): hence there were 166 relatives who developed diabetes in the present study as opposed to 171 in our previous publication using data from the same cohort. ©2018 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-2462/-/DC1 SUPPLEMENTARY DATA SupplementaryFigure 2.Progression from first single autoAb positivity to type 1 diabetes (panels A-C) or to multiple autoAb-positivity (panels D-F) according to the presence (broken line) or the absence (full line) of HLA-A*24 (panels A, D), HLA-B*18 (panels B, E) or HLA-B*39 (panels C, F). ©2018 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-2462/-/DC1 SUPPLEMENTARY DATA SupplementaryFigure 3.Progression from first single autoAb positivity to multiple autoAb positivity according to the presence (broken line) or the absence (full line) of HLA-A*24 in relatives initially positive for IAA (panel A) or GADA (panel B). ©2018 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-2462/-/DC1 SUPPLEMENTARY DATA SupplementaryFigure 4.Progression from the high-risk (HR) autoAb profile (IA-2A+or ZnT8A+ plus at least one other autoAb+) to type 1 diabetes (panel A) according to the four possible combinations of presence or absence of HLA-A*24 and/or -DQ8; progression from positivity for IAA and GADA only (LR profile) to type 1 diabetes (panel B) according to the four possible combinations of presence or absence ofHLA-B*18 and/or -DQ2. One multiple autoAb+ relative was excluded from this analysis, because autoAb-inferred risk-status at baseline could not be determined, because ofa missing result for ZnT8A. ©2018 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-2462/-/DC1 SUPPLEMENTARY DATA Appendix Members of the Belgian Diabetes Registry: Abrams P, St Augustinus, Wilrijk; Algoet C, St Elisabeth Ziekenhuis, Herentals; Annaert M, AZ Diest Campus Statiestraat, Diest; Arnouts P, AZ St Jozef, Turnhout; Ayoubi S, Clinique St Jean, Bruxelles; Bachy A, Clinique Notre Dame, Charleroi; Ballaux D, AZ Nikolaas, Sint-Niklaas; Baltieri D, Private, Haine-Saint-Paul; Bataille G, CH du Grand Hornu-Frameries, Hornu; Beckers D, UCL Mt. Godinne, Yvoir; Beckers V, CH St Joseph, Liège; Becq H, St Augustinus, Wilrijk; Beirinckx A, AZ St Lucas, Assebroek; Bellavia S, CHR de Huy, Huy; Benhalima K, UZ Leuven Gasthuisberg, Leuven; Bex M, UZ Leuven Gasthuisberg, Leuven; Bodson A, Polyclinique du Mambourg, Charleroi; Bollaerts K, AZ St Maarten Campus Mechelen, Mechelen; Bosly F, Clinique St Joseph, Arlon; Bouquegneau M, CHU Ambroise Paré, Mons; Bourguignon J, CHU Sart Tilman, Liège; Bravenboer B, UZ Brussel, Brussel (Jette); Brochier S, IFAC Clinique St.-Thérèse, Bastogne; Bruno S, Clinique Notre Dame, Tournai; Brussaard H, Jessa Ziekenhuis - Campus Virga-Jesse, Hasselt; Burniat A, Hôpital Erasme, Bruxelles; Buysschaert M, Clinique Univ St Luc, Bruxelles; Carlier A, AZ Maria Middelares, Gent; Casteels K, UZ Leuven Gasthuisberg, Leuven; Cavatorta E, Hôpital Civil Marie Curie, Lodelinsart; Chivu O, CHR Clinique St Joseph, Liège; Claessens A, Clinique St Joseph, Arlon; Claeys L, AZ St Jozef, Malle; Claeys M, St Vincentius Ziekenhuis, Antwerpen; Cnop M, Hôpital Erasme, Bruxelles; Cochez P, St Augustinus Kliniek, Veurne; Coeckelberghs M, Kinderziekenhuis Paola, Antwerpen; Col V, Clinique St Pierre, Ottignies; Colson A, Clinique St Pierre, Ottignies; Coolens J, Jessa Ziekenhuis - Campus Salvator, Hasselt; Coremans P, AZ Nikolaas, Sint-Niklaas; Corman V, CHR de la Citadelle, Liège; Corvilain B, Hôpital Erasme, Bruxelles; Coucke F, Private, Antwerpen; Crape A, OLV van Lourdes, Waregem; Crenier L, Hôpital Erasme, Bruxelles; Daems T, ZNA Stuivenberg, Antwerpen; Damoiseaux P, CH de Dinant, Dinant; Daoudi N, Hôpital Civil Marie Curie, Lodelinsart; Daper C, CHU Tivoli, La Louvière; Daubresse C, CH St Joseph, Liège; Daubresse J, Hôpital Civil Marie Curie, Lodelinsart; De Block C, UZA, Edegem; De Brouckère V, CHU Tivoli, La Louvière; De Feyter I, AZ De Bijloke, Gent; De Grande E, St Andriesziekenhuis, Tielt; De Keyser L, ZNA Stuivenberg, Antwerpen; De Keyzer K, Stadskliniek, Sint Niklaas; De Leu N, Algemeen Stedelijk Ziekenhuis, Aalst; De Paepe L, ZNA Stuivenberg, Antwerpen; De Schepper J, UZ Brussel, Brussel (Jette); De Schynkel K, AZ Maria Middelares, Gent; De Waele K, UZ Gent, Gent; De Wasch G, Henri Serruys Ziekenhuis, Oostende; De Winter P, Heilige Familie, Rumst; Decerf J, CH de l'Ardenne, Libramont; Decochez K, AZ Jan Portaels, Vilvoorde; Decraene P, Imeldaziekenhuis, Bonheiden; Defacq L, Regionaal Ziekenhuis Heilig Hart, Tienen; Defoer F, Militair Hospitaal, Brussel; Demuynck S, AZ Heilige Familie, Reet; Den Brinker M, UZA, Edegem; Depoorter S, AZ St Jan, Brugge; Derdelinckx L, Clinique Saint Luc, Bouge-Namur; Deweer S, St Elisabeth Ziekenhuis, Zottegem; Dooms L, Private, Bree; Dorchy H, HUDERF, Bruxelles; Dotremont H, UZA, Edegem; Driessens S, AZ KLINA, Brasschaat; Dumasy V, Clinique Louis Caty, Baudour; Duvivier E, Clinique Reine Fabiola, Montignies-sur-Sambre; Duyck F, H Hart Ziekenhuis, Roeselare; Dysseleer A, CH de l'Ardenne, Libramont; Eeckhout B, AZ St Dimpna, Geel; Eenkhoorn V, St Jozef Kliniek, Bornem; Emsens L, AZ OLV Ter Linden, Knokke-Heist; Engelen W, AZ Stuivenberg, Antwerpen; Ers V, Clinique St Joseph, Arlon; Eykens A, Private, Herentals; Favere N, St Elisabethziekenhuis, Zottegem; Fils R, Private, Blankenberge; Fouckova A, AZ Zusters van Barmhartigheid, Ronse; France A, UZA, Edegem; Frankart L, Private, Ceroux-Mousty; Garmyn K, Private, Lier; Gellner K, CHR de la Citadelle, Liège; Gerard J, Private, Plainevaux; Gerniers S, Private, Sint-Denijs-Westrem; Geronooz I, CHR Clinique St Joseph, Liège; Geyskens L, AZ St Jozef, Turnhout; Ghys C, UZ Brussel, Brussel (Jette); Gies I, UZ Brussel, Brussel (Jette); Gillard P, UZ Leuven Gasthuisberg, Leuven; Godon E, CHR de Huy, Huy; Grabczan L, CHU Saint-Pierre, Bruxelles; Guiot J, Hôpital du Bois de l' Abbaye, Seraing; Haemers A, Maria Ziekenhuis Noord Limburg, Overpelt; ©2018 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-2462/-/DC1 SUPPLEMENTARY DATA Haumont S, Hôpital Erasme, Bruxelles; Herbaut C, CHU Brugmann, Bruxelles; Heureux F, Clinique St Elisabeth, Namur; Heureux M, CHU A. Vésale, Montigny-le-Tilleul; Heyns E, AZ Groeninge Campus OLV, Kortrijk; Hilbrands R, UZ Brussel, Brussel (Jette); Horlebein B, St Franciscus Ziekenhuis, Heusden Zolder; Huard A, Hôpital de Braine l'Alleud, Braine l'Alleud; Hubermont G, Clinique Princesse Paola, Marche; Husein D, AZ Nikolaas, Sint-Niklaas; Huyghe J, Private, St. Niklaas; Huysman F, AZ St Lucas, Gent; Iconaru L, CHU Brugmann, Bruxelles; Immegeers V, Algemeen Stedelijk Ziekenhuis, Aalst; Jandrain B, CHU Sart Tilman, Liège; Joosen P, Maria Ziekenhuis Noord Limburg, Overpelt; Jopart P, Hôpital de Jolimont, Haine-St-Paul; Jousten E, CHR de la Citadelle, Liège; Karmali R, CHU Brugmann, Bruxelles; Keymeulen B, UZ Brussel, Brussel (Jette); Kleynen P, CHU Saint-Pierre, Bruxelles; Kockaerts Y, ZOL Campus A. Dumont, Genk; Krzentowski G, Polyclinique du Mambourg, Charleroi; Kums R, Regionaal Ziekenhuis Heilig Hart, Tienen; Laga K, St Franciscus Ziekenhuis, Heusden Zolder; Lambrecht E, Private, Dendermonde; Lapauw B, UZ Gent, Gent; Lebrethon M, CHR de la Citadelle, Liège; Lee A, AZ KLINA, Brasschaat; Lemay A, UZA, Edegem; Lemay P, AZ Sint-Jozef, Turnhout; Lemy C, Hôpital Civil Marie Curie, Lodelinsart; Leuridan L, AZ KLINA, Brasschaat; Leus J, AZ Maria Middelares, Gent; Liénart F, CHU Tivoli, La Louvière; Lim T, Heilig Hart Ziekenhuis, Mol; Litvine C, CHU Ambroise Paré, Mons; Logghe K, H Hart Ziekenhuis, Roeselare; Louis J, Clinique Notre Dame, Charleroi; Lowyck I, ZOL Campus A. Dumont, Genk; Lysy P, UCL St. Luc, Bruxelles; Maes M, Clinique Univ St Luc, Bruxelles; Maes T, Imeldaziekenhuis, Bonheiden; Maes W, Algemeen Ziekenhuis Oudenaarde, Oudenaarde; Marchal M, CHU Tivoli, La Louvière; Marcq P, Ziekenhuis Maas en Kempen - Campus Maaseik, Maaseik; Marien P, St Augustinus, Wilrijk; Maris E, AZ Nikolaas, Sint-Niklaas; Martens M, AZ Sint-Jozef, Turnhout; Massa G, Jessa Ziekenhuis - Campus Virga-Jesse, Hasselt; Massaad D, Algemeen Stedelijk Ziekenhuis, Aalst; Mathieu C, UZ Leuven Gasthuisberg, Leuven; Mathijs Z, Algemeen Stedelijk Ziekenhuis, Geraardsbergen; Maus Y, Private, Liège; Mekahli F, Clinique St Jean, Bruxelles; Mekeirele K, OLV van Lourdes, Waregem; Mertens A, Regionaal Ziekenhuis Sint Trudo, Sint-Truiden; Messaaoui A, HUDERF, Bruxelles; Monballyu J, AZ KLINA, Brasschaat; Moorkens G, UZA, Edegem; Mortelmans K, Regionaal Ziekenhuis