An Indicator of Triplet State Baird-Aromaticity
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Cyclobutene Photochemistry. Steric Effects on the Photochemical Ring Opening of Alkylcyclobutenes
1688 J. Am. Chem. SOC.1995,117, 1688-1694 Cyclobutene Photochemistry. Steric Effects on the Photochemical Ring Opening of Alkylcyclobutenes William J. Leigh* and J. Albert0 Postigo Contribution ffom the Department of Chemistry, McMaster University, Hamilton, Ontario, Canada US4Ml Received August 19, 1994@ Abstract: Quantum yields for photochemical ring opening and cycloreversion in hydrocarbon solution have been determined for the direct photolysis (214 nm) of six 1,2-dimethylcyclobutenederivatives which contain methyl groups at C3 and C4 in numbers varying from zero to four. As the hydrogens on C& of the parent compound (1,2- dimethylcyclobutene)are replaced with increasing numbers of methyl groups, the total quantum yield for ring opening increases to a maximum of -0.3 and then decreases with further methyl substitution. The quantum yields for ring opening (&tal) of hexamethylcyclobutene and 1,2-dimethylcyclobuteneare nearly the same, and the lowest in the series. The maximum occurs with trans- 1,2,3,4-tetramethylcyclobutene;q5tod for the cis-isomer is significantly lower, but both yield an approximate 1:l mixture of formally allowed and forbidden diene isomers. A similar trend is observed in the relative quantum yields for ring opening and cycloreversion throughout the series. The results are interpreted in terms of a combination of bond strength and steric effects on the efficiency of the ring-opening process. Increasing methyl substitution causes an increase in @total through the first three members of the series owing to progressive weakening of the C3-C4 bond. Compounds containing cis-dimethyl substitution exhibit substantially reduced quantum yields for ring opening, relative to what would be expected based on bond strength effects alone. -
New Applications of Cyclobutadiene Cycloadditions: Diversity and Target Oriented Synthesis
New Applications of Cyclobutadiene Cycloadditions: Diversity and Target Oriented Synthesis Author: Jason Joseph Marineau Persistent link: http://hdl.handle.net/2345/1741 This work is posted on eScholarship@BC, Boston College University Libraries. Boston College Electronic Thesis or Dissertation, 2010 Copyright is held by the author, with all rights reserved, unless otherwise noted. Boston College The Graduate School of Arts and Sciences Department of Chemistry NEW APPLICATIONS OF CYCLOBUTADIENE CYCLOADDITIONS: DIVERSITY AND TARGET ORIENTED SYNTHESIS a dissertation by JASON JOSEPH MARINEAU submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy December 2010 © Copyright by JASON JOSEPH MARINEAU 2010 New Applications of Cyclobutadiene Cycloadditions: Diversity and Target Oriented Synthesis Jason J. Marineau Thesis Advisor: Professor Marc. L. Snapper Abstract Cyclobutadiene cycloadditions provide rapid access to rigid polycyclic systems with high strain energy and unusual molecular geometries. Further functionalization of these systems allows entry into unexplored chemical space. A tricarbonylcyclobutadiene iron complex on solid support enables exploration of these cycloadditions in a parallel format amenable to diversity oriented synthesis. Modeling of the cycloaddition transition states with density functional calculations provides a theoretical basis for analysis of the regioselectivity observed in generation of these substituted bicyclo[2.2.0]hexene derivatives. The high strain energy accessible in cyclobutadiene cycloadducts and their derivatives renders them useful synthons for access to medium-ring natural products through ring expansion. Torilin, a guaiane sesquiterpene isolated from extracts of the fruits of Torilis japonica, exhibits a range of biological activities including testosterone 5 -reductase inhibition, hKv1.5 channel blocking, hepatoprotective, anti-inflammatory and anti-cancer effects. -
Organic Chemistry
Organic Chemistry Organic Chemistry Theory, Reactivity and Mechanisms in Modern Synthesis With a Foreword by Robert H. Grubbs Pierre Vogel Kendall N. Houk Authors All books published by Wiley-VCH are carefully produced. Neverthe- less, authors, editors, and publisher do not warrant the information con- Prof. Pierre Vogel tained in these books, including this book, to be free of errors. Readers EPFL are advised to keep in mind that statements, data, illustrations, procedu- SB-DO ral details or other items may inadvertently be inaccurate. Avenue F.-A. Forel 2 1015 Lausanne Library of Congress Card No.: Switzerland applied for Prof. Kendall N. Houk British Library Cataloguing-in-Publication Data Dept. of Chemistry and Biochemistry A catalogue record for this book is available from the British Library. University of California Los Angeles, CA 90095–1569 Bibliographic information published by United States the Deutsche Nationalbibliothek The Deutsche Nationalbibliothek lists this publication in the Deutsche Cover: The cover features a computed Nationalbibliografie; detailed bibliographic data are available on the transition state structure with frontier Internet at <http://dnb.d-nb.de>. molecular orbitals for the Diels-Alder reaction of SO2 and butadiene, catalyzed © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 by another SO2 (J. Am. Chem. Soc. 1998, Weinheim, Germany 120, 13276–13277). Pierre Vogel established the mechanism of this All rights reserved (including those of translation into other languages). reaction and applied it to the total No part of this book may be reproduced in any form – by photoprinting, synthesis of natural product microfilm, or any other means – nor transmitted or translated into a (-)-dolabriferol (Angew. -
CHEMISTRY 412/512 MIDTERM # 1 – Answer Key February 14, 2007 1
CHEMISTRY 412/512 MIDTERM # 1 – answer key February 14, 2007 1. (8 pts) Acyl cations ( RCO ) are key intermediates in Friedel – Crafts acylation reactions. They are stabilized by the presence of oxygen and this can be demonstrated through either resonance or MO analysis. a. Consider the formyl cation, shown below. Show how it is stabilized, using appropriate resonance structures. HCO formyl cation HCO HCO Acyl cations are stabilized by conjugation of one of the lone pairs at the oxygen center. b. Construct the orbital mixing diagram for the formyl cation, starting with group orbitals for CH and O-atom. Consider only first order mixing. Place the appropriate number of valence electrons and demonstrate how QMOT explains the stabilization of the cation. O HC The mixing diagram clearly shows the formation of TWO equivalent π-bonds, which is analogous to the resonance structure on the right, i.e. there is significant contribution by the O-atom. 2. (6 pts) Antiaromatic molecules avoid antiaromaticity by structural distortion. For example, cyclobutadiene is not square (and antiaromatic) but rectangular. Show, using π-group orbital analysis, that such distortion would indeed be stabilizing. square rectangular Solution: Instability of square cyclobutadiene is due to the presence of two degenerate, half-filled π-molecular orbitals (π2 and π3). In the rectangular form, qualitatively, the MOs remain the same, but the strength of some bonding/antibonding interactions is affected and it causes the degeneracy to be lifted. Focus on π2 and π3. Upon stretching, the antibonding interaction in π2 is reduced, while the same geometric distortion leads to reduction of the bonding interaction in π3. -
Exploring Antiaromaticity in Single-Molecule Junctions Formed
Nanoscale View Article Online PAPER View Journal | View Issue Exploring antiaromaticity in single-molecule junctions formed from biphenylene derivatives† Cite this: Nanoscale, 2019, 11, 20659 Markus Gantenbein,‡a Xiaohui Li, ‡b Sara Sangtarash, *‡c Jie Bai, b Gunnar Olsen, a Afaf Alqorashi,c Wenjing Hong, *b Colin J. Lambert *c and Martin R. Bryce *§a We report the synthesis of a series of oligophenylene-ethynylene (OPE) derivatives with biphenylene core units, designed to assess the effects of biphenylene antiaromaticity on charge transport in molecular junctions. Analogues with naphthalene, anthracene, fluorene and biphenyl cores are studied for compari- son. The molecules are terminated with pyridyl or methylthio units. Single-molecule conductance data were obtained using the mechanically controllable break junction (MCBJ) technique. It is found that when electrons pass from one electrode to the other via a phenylene ring, the electrical conductance is almost independent of the nature of the pendant π-systems attached to the phenylene ring and is rather insensi- Creative Commons Attribution 3.0 Unported Licence. tive to antiaromaticity. When electrons pass through the cyclobutadiene core of the biphenylene unit, transport is sensitive to the presence of the relatively weak single bonds connecting the two phenylene rings of biphenylene, which arise from partial antiaromaticity within the cyclobutadiene core. This leads to Received 25th June 2019, a negligible difference in the molecular conductance compared to the fluorene or biphenyl analogues Accepted 26th August 2019 which have standard single bonds. This ability to tune the conductance of molecular cores has no ana- DOI: 10.1039/c9nr05375a logue in junctions formed from artificial quantum dots and reflects the quantum nature of electron trans- rsc.li/nanoscale port in molecular junctions, even at room temperature. -
Cyclobutene Photochemistry. Identification of the Excited States Responsible for the Ring-Opening and Cycloreversion Reactions of Alkylcyclobutenes
J. Am. Chem. SOC.1991, 113,4993-4999 4993 Cyclobutene Photochemistry. Identification of the Excited States Responsible for the Ring-Opening and Cycloreversion Reactions of Alkylcyclobutenes W. J. Leigh,*?" K. Zheng,= N. Nguyen, N. H. Werstiuk, and J. Ma" Contribution from the Department of Chemistry, McMaster University, Hamilton, Ontario, Canada US4Ml. Received November 28, 1990. Revised Manuscript Received March 7, 1991 Abstract: Two substituted bicyclic cyclobutene derivatives-7-methyl- and 7-(trifluoromethyl)bicyclo[4.2.0]oct-7-enehave been prepared. Gas- and solution-phase UV absorption and He1 UV photoelectron spectra have been recorded for the two compounds as well as for the parent hydrocarbon bicyclo[4.2.0]oct-7-ene. The gas-phase spectra suggest that the a,R(3s) state is the lowest energy state in bicyclo[4.2.0]octene and the 7-methyl derivative but is raised to higher energies than the *,A* state in the 7-trifluoromethylderivative. Direct photolysis of the three compounds in hydrocarbon solution with monochromatic far-UV (1 93 and 214 nm) light leads to competitive ring opening to the corresponding cis,cis- and cis,trans-l,3-cyclooctadiene derivatives, as well as fragmentation to cyclohexene and alkyne in all three cases. Product quantum yields (193-nm excitation) have been measured for both substituted derivatives relative to those for the parent compound. The quantum yields of fragmentation products are highest for the methyl- and unsubstituted compounds, suggesting that these products arise from a Rydberg-like excited state. In contrast, ring opening is most efficient for the trifluoromethyl-substituted compound, although the diene distributions obtained from the reaction do not vary throughout the series. -
Exploitation of Baird Aromaticity and Clar's Rule for Tuning The
Article Exploitation of Baird Aromaticity and Clar’s Rule for Tuning the Triplet Energies of Polycyclic Aromatic Hydrocarbons Felix Plasser Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK; [email protected] Abstract: Polycyclic aromatic hydrocarbons (PAH) are a prominent substance class with a variety of applications in molecular materials science. Their electronic properties crucially depend on the bond topology in ways that are often highly non-intuitive. Here, we study, using density functional theory, the triplet states of four biphenylene-derived PAHs finding dramatically different triplet excitation energies for closely related isomeric structures. These differences are rationalised using a qualitative description of Clar sextets and Baird quartets, quantified in terms of nucleus independent chemical shifts, and represented graphically through a recently developed method for visualising chemical shielding tensors (VIST). The results are further interpreted in terms of a 2D rigid rotor model of aromaticity and through an analysis of the natural transition orbitals involved in the triplet excited states showing good consistency between the different viewpoints. We believe that this work constitutes an important step in consolidating these varying viewpoints of electronically excited states. Keywords: aromaticity; antiaromaticity; chemical shift; hydrocarbons, benzene; p-conjugated systems Citation: Plasser, F. Exploitation of Baird Aromaticity and Clar’s Rule for 1. Introduction Tuning the Triplet Energies of Polycyclic Aromatic Hydrocarbons. Polycyclic aromatic hydrocarbons (PAHs) are a fascinating class of molecules provid- Chemistry 2021, 3, 532–549. http:// ing versatile organic semi-conductors [1] for a variety of use cases such as photovoltaics [2] doi.org/10.3390/chemistry3020038 including singlet fission [3,4], charge transport [5], and field-effect transistors [6]. -
Cycloalkanes, Cycloalkenes, and Cycloalkynes
CYCLOALKANES, CYCLOALKENES, AND CYCLOALKYNES any important hydrocarbons, known as cycloalkanes, contain rings of carbon atoms linked together by single bonds. The simple cycloalkanes of formula (CH,), make up a particularly important homologous series in which the chemical properties change in a much more dramatic way with increasing n than do those of the acyclic hydrocarbons CH,(CH,),,-,H. The cyclo- alkanes with small rings (n = 3-6) are of special interest in exhibiting chemical properties intermediate between those of alkanes and alkenes. In this chapter we will show how this behavior can be explained in terms of angle strain and steric hindrance, concepts that have been introduced previously and will be used with increasing frequency as we proceed further. We also discuss the conformations of cycloalkanes, especially cyclo- hexane, in detail because of their importance to the chemistry of many kinds of naturally occurring organic compounds. Some attention also will be paid to polycyclic compounds, substances with more than one ring, and to cyclo- alkenes and cycloalkynes. 12-1 NOMENCLATURE AND PHYSICAL PROPERTIES OF CYCLOALKANES The IUPAC system for naming cycloalkanes and cycloalkenes was presented in some detail in Sections 3-2 and 3-3, and you may wish to review that ma- terial before proceeding further. Additional procedures are required for naming 446 12 Cycloalkanes, Cycloalkenes, and Cycloalkynes Table 12-1 Physical Properties of Alkanes and Cycloalkanes Density, Compounds Bp, "C Mp, "C diO,g ml-' propane cyclopropane butane cyclobutane pentane cyclopentane hexane cyclohexane heptane cycloheptane octane cyclooctane nonane cyclononane "At -40". bUnder pressure. polycyclic compounds, which have rings with common carbons, and these will be discussed later in this chapter. -
Recent Studies on the Aromaticity and Antiaromaticity of Planar Cyclooctatetraene
Symmetry 2010 , 2, 76-97; doi:10.3390/sym2010076 OPEN ACCESS symmetry ISSN 2073-8994 www.mdpi.com/journal/symmetry Review Recent Studies on the Aromaticity and Antiaromaticity of Planar Cyclooctatetraene Tohru Nishinaga *, Takeshi Ohmae and Masahiko Iyoda Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan; E-Mails: [email protected] (T.O.); [email protected] (M.I.) * Author to whom correspondence should be addressed; E-Mail: [email protected]. Received: 29 December 2009; in revised form: 23 January 2010 / Accepted: 4 February 2010 / Published: 5 February 2010 Abstract: Cyclooctatetraene (COT), the first 4n π-electron system to be studied, adopts an inherently nonplanar tub-shaped geometry of D2d symmetry with alternating single and double bonds, and hence behaves as a nonaromatic polyene rather than an antiaromatic compound. Recently, however, considerable 8 π-antiaromatic paratropicity has been shown to be generated in planar COT rings even with the bond alternated D4h structure. In this review, we highlight recent theoretical and experimental studies on the antiaromaticity of hypothetical and actual planar COT. In addition, theoretically predicted triplet aromaticity and stacked aromaticity of planar COT are also briefly described. Keywords: antiaromaticity; cyclooctatetraene; NMR chemical shifts; quantum chemical calculations; ring current 1. Introduction Cyclooctatetraene (COT) was first prepared by Willstätter in 1911 [1,2]. At that time, the special stability of benzene was elusive and it was of interest to learn the reactivity of COT as the next higher vinylogue of benzene. However, unlike benzene, COT was found to be highly reactive to electrophiles just like other alkenes. -
Alkenes and Alkynes
02/21/2019 CHAPTER FOUR Alkenes and Alkynes H N O I Cl C O C O Cl F3C C Cl C Cl Efavirenz Haloprogin (antiviral, AIDS therapeutic) (antifungal, antiseptic) Chapter 4 Table of Content * Unsaturated Hydrocarbons * Introduction and hybridization * Alkenes and Alkynes * Benzene and Phenyl groups * Structure of Alkenes, cis‐trans Isomerism * Nomenclature of Alkenes and Alkynes * Configuration cis/trans, and cis/trans Isomerism * Configuration E/Z * Physical Properties of Hydrocarbons * Acid‐Base Reactions of Hydrocarbons * pka and Hybridizations 1 02/21/2019 Unsaturated Hydrocarbons • Unsaturated Hydrocarbon: A hydrocarbon that contains one or more carbon‐carbon double or triple bonds or benzene‐like rings. – Alkene: contains a carbon‐carbon double bond and has the general formula CnH2n. – Alkyne: contains a carbon‐carbon triple bond and has the general formula CnH2n‐2. Introduction Alkenes ● Hydrocarbons containing C=C ● Old name: olefins • Steroids • Hormones • Biochemical regulators 2 02/21/2019 • Alkynes – Hydrocarbons containing C≡C – Common name: acetylenes Unsaturated Hydrocarbons • Arene: benzene and its derivatives (Ch 9) 3 02/21/2019 Benzene and Phenyl Groups • We do not study benzene and its derivatives until Chapter 9. – However, we show structural formulas of compounds containing a phenyl group before that time. – The phenyl group is not reactive under any of the conditions we describe in chapters 5‐8. Structure of Alkenes • The two carbon atoms of a double bond and the four atoms bonded to them lie in a plane, with bond angles of approximately 120°. 4 02/21/2019 Structure of Alkenes • Figure 4.1 According to the orbital overlap model, a double bond consists of one bond formed by overlap of sp2 hybrid orbitals and one bond formed by overlap of parallel 2p orbitals. -
Developing a S Ystem to Study the Dynamics of the Heterolysis of Psubstituted Radicals in Terms of Magnetic Field Effects
Developing a S ystem to Study the Dynamics of the Heterolysis of PSubstituted Radicals in terms of Magnetic Field Effects by Elaine K. Adams Submitted in partial fulfiiIlment of the requirements for the degree of Master of Science Dalhousie University Halifax, Nova Scotia September, 1998 @ Copyright by Elaine K. Adams, 1998 National hirary Bibliothèque nationale du Canada Acquisitions and Acquisiins et Biliograpfii Services seMces bibliographiques The author has granted a non- L'auteur a accordé une licence non exclusive licence allowing the exclusive permettant à la National Library of Canada to Bibliothèque nationale du Canada de reproduce, loan, distribute or seli reproduire, prêter, distriiuer ou copies of this thesis in microform, vendre des copies de cette thèse sous paper or electronic formats. la forme de micro fi ch el^ de reproduction sur papier ou sur fonnat électronique. The author retains ownership of the L'auteur conserve la propriété du copyright in this thesis. Neither the droit d'auteur qui protège cette thèse. thesis nor substantial extracts fkom it Ni la thése ni des extraits substantiels may be printed or otherwise de celle-ci ne doivent être imprimés reproduced without the author's ou autrement reproduits sans son permission. autorisation. Table of Contents List of Figures ........................................................................................ vi ... List of Tables ........................................................................................ xm 1.1 General Introduction ....................................................................... -
Aromaticity, Antiaromaticity, Homoaromaticity and the Hückel (4N + 2) Rule
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/329877657 Aromaticity, Antiaromaticity, Homoaromaticity and the Hückel (4n + 2) Rule Presentation · December 2018 DOI: 10.13140/RG.2.2.34131.63528 CITATIONS READS 0 36,125 1 author: Dr Sumanta Mondal GITAM (Deemed to be University) 259 PUBLICATIONS 510 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: SARS-CoV-2 View project Natural Products View project All content following this page was uploaded by Dr Sumanta Mondal on 10 May 2021. The user has requested enhancement of the downloaded file. Aromaticity, Antiaromaticity and the Hückel (4n + 2) Rule ❖ Aromaticity - In 1931, German chemist and physicist Sir Erich Hückel proposed a theory to help determine if a planar ring molecule would have aromatic properties. His rule states that if a cyclic, planar molecule has 4n+2 π electrons, it is considered aromatic. This rule would come to be known as Hückel's Rule. • Criteria for Aromaticity 1) The molecule is cyclic (a ring of atoms) 2) The molecule is planar (all atoms in the molecule lie in the same plane) 3) The molecule is fully conjugated (p orbitals at every atom in the ring) 4) The molecule has 4n+2 π electrons (n=0 or any positive integer) • Why 4n+2 π Electrons? - According to Hückel's Molecular Orbital Theory, a compound is particularly stable if all of its bonding molecular orbitals are filled with paired electrons. - This is true of aromatic compounds, meaning they are quite stable.