Systems Neuropsychiatry of Preamble One special role is played by the endocannabinoid Stress, Anxiety and Today, neuropsychiatry is facing the challenge to system, which is mainly inhibiting the electrical ‘understand’ an overwhelming amount of data. It is reactivity of the respective neuron and even has - an integrated view – assumed that empirical findings can ‘explain’ clinical retrograde presynaptic signalling properties. phenomena and lead the development to new Additionally, the intracellular molecular signalling therapeutic tools. However, ‘complexity’ and ’dynamics’ network, connected to dopamine signalling May, Fri 03 / Sat 04, 2013 of the brain are the methodological key challenges for pathways, is analysed by exploratory computational

th current theories in neurobiology which need new models. Finally, the interplay between the genome, 9 International Workshop on approaches for understanding. We think this approach the proteome, the transcriptome and the epigenome Computational Neuropsychiatry could be based on systems methodology. Systems (Nestler) is being explored. methodology can be characterised by a multi-level The symposium aims to find a better understanding

Alcohol approach, by mathematical tools of complexity of the pathways from stress and anxiety to reduction and formal and computational modelling, addiction, as one of the most important public NOREPINEPHRINE ACETYLCHOLINE aiming at computer-based in-silico experimentation. The health issues. systems approach is closely related to in-vivo and Contact: F. Tretter SEROTONIN in-vitro experimentation developing its ideas in an GLUTAMATE iteractive way. In this field systems scientists, Phone: ++49-89-4562-3708 Fax: -3754 DOPAMINE GABA Email: [email protected] experimental neurobiologists and clinicians work

together in order to improve the understanding of mental Registration (no registration fee): Department of disorders on a biological basis. [email protected] University of In this context, in our 9th symposium on ‘Systems Programme & Organization Committee: Alois-Alzheimer-Saal Neuropsychiatry’, we will discuss integrative concepts Felix TRETTER, Margot ALBUS Nussbaumstrasse 7 of ‘Stress, Anxiety and Addiction’. Here, we would like Isar Amper Clinics, Clinic Munich East Munich, to present integrated functional knowledge of circuits of Dan RUJESCU, Oliver POGARELL, Eva MEISENZAHL stress and anxiety (Mcewen, Panksepp) which are Department of Psychiatry, University of Munich interconnected with circuits of addiction (Volkow). Risk Peter GEBICKE HAERTER factors for addiction like ‘impulsivity’ (Everitt) are key Central Institute of Mental Health, Mannheim factors to be discussed from an interdisciplinary Hans BRAUN perspective. Concepts like ‘regulation’, ‘dysbalance’, Physiological Institute, University of Marburg ‘adaptation’ (Allostasis; Koob & LeMoal) are crucial in Supported by: Hans-Werner MEWES this macro-structural context. Regarding the Institute of Bioinformatics and biochemical level, the dopaminergic transmission Helmholtz Zentrum München system is essential for acquiring addictive dispositions Christoph TURCK by reward mechanisms, but it is not the whole story: Max Planck Institute of Psychiatry, Munich reward itself is a complex process (Berridge) and should Till ROENNEBERG be related to the opposing process of punishment, for Medical , University of Munich instance the serotonergic transmission system (Dayan). Eduardo MENDOZA Also, the nonlinear dynamics of synaptic dopaminergic Physics Department, University of Munich

computation have to be discussed with the aid of Walter E. MÜLLER computational models (Voit). Department of Pharmacology, University of Frankfurt

PROGRAMME 16.30 Break 9.45 Moderation: Michael ZEHETLEITNER (45 min = 30 min talk, 15 min discussion; (Psychology, Univ. of Munich, G) 30 min = 20 min talk, 10 min discussion) 17. 00 Moderation: Oliver POGARELL (Dept. of Chris TURCK (MPI for Psychiatry, Munich, G) Psychiatry, Univ. of Munich, G) Anxiety biosignatures Barry EVERITT (Downing College Cambridge, UK) ------Friday, May 03, 2013 ------Vulnerability: neural circuits and switches from 10.15 Moderation: Stephan SELLMAIER impulsivity to compulsivity (Neurophilosophy, Univ. of Munich, G) 13.00 Welcome Maurizio POPOLI (Neuropharmacology, Univ. INTRODUCTION 17.45 Moderation: Dan RUJESCU (Dept. of Psychiatry of Milan, I) Oliver POGARELL / Felix TRETTER / Margot Univ. of Halle, G) Epigenetic regulation in the stress response and ALBUS / Dan RUJESCU / Chris TURCK / Philippe DE WITTE (Univ. of Louvain, B) vulnerability for neuropsychiatric disorders Werner MEWES / Eva MEISENZAHL Imbalance between neuroexcitatory and -inhibitory amino acids causes craving for nicotine and ethanol 10.45 Break CLINICAL ASPECTS 13.15 Moderation: John DITTAMI (Behavioural KEYNOTE LECTURE 11.15 Moderation: Uwe AN DER HEIDEN (Chair Biology, Univ. of , A) of Mathematics, Witten-Herdecke, G) Felix TRETTER (Dept. of Addiction, IAK- 18.30 Moderation: Matthias MUNK (MPI Biol. Francois IRIS (bmsystems, Paris, F) KMO, Munich, G) , Tübingen, G) Moelcular pathways of anxiety Perspectives of systems neuropsychiatry of Viktor JIRSA (Univ. of Marseille, F) stress, anxiety and addiction The Human Connectome Project 11.45 Moderation: Peter GEBICKE-HAERTER (Mannheim, G and Chile ) 14.00 Moderation: Andreas DRAGUHN 19.15 Invited Discussant: Hans-Werner MEWES Eberhard VOIT & Zen QUI (Georgia Institute (Physiology, Univ. of Heidelberg, G) of Technology, Georgia, USA) Andreas J. FALLGATTER (Dept. of 20.00 End Molecular biological mechanisms of addiction Psychiatry, Univ. of Tübingen, G) The Neurobiology of stress and anxiety 20.30 Dinner 12.15 Moderation: Gustavo DECO (Univ. of Barcelona, E) 14.45 Break Boris GUTKIN (École Normale Supérieure, Paris, F) 15.00 Moderation: Ulrich MANSMANN ------Saturday, May 04, 2013 ------Computational model of mechanisms of (Bioinformatics, Univ. of Munich, G) Ulrich ZIMMERMANN (Dept. of Psychiatry, BASIC RESEARCH Univ. of Dresden, G) 13.00 FINAL DISCUSSION Neurobiology of stress and addiction 09.00 Moderation: Hans BRAUN (Physiology, Univ. of Moderation: Oliver POGARELL / Dan RUJESCU / Marburg, G) Felix TRETTER 15.45 Moderation: Eva MEISENZAHL Rafael MALDONADO (Neuropharmacology, Univ. (Psychiatry, Univ. of Munich, G) of Pompeu Fabra, Barcelona, E) 13.30 END OF WORKSHOP Boris TABAKOFF (Dept. of Pharmacology, Information processing in the endocannabinoid Univ. of Colorado, Denver, USA) system Molecular neurobiology of alcoholism and new treatment options