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Molecular, Cellular and Developmental 1

Anseth, Kristi S. (https://experts.colorado.edu/display/fisid_103471/) MOLECULAR, CELLULAR AND Distinguished Professor; PhD, University of Colorado Boulder DEVELOPMENTAL BIOLOGY Betterton, Meredith D. (https://experts.colorado.edu/display/ fisid_125396/) The undergraduate program in molecular, cellular and developmental Associate Professor; PhD, Harvard University biology (MCDB) is directed toward understanding the molecular and Blumenthal, Thomas (https://experts.colorado.edu/display/ cellular mechanisms that provide the basis for biological structure, fisid_143346/) growth, , embryonic and genetic inheritance. Professor, Visiting Professor; PhD, Johns Hopkins University Undergraduate majors learn about the scientific method, experimental approaches and groundbreaking discoveries that have made modern Boswell, Robert E. (https://experts.colorado.edu/display/fisid_100196/) molecular and cellular biology such an important force in medicine, Professor; PhD, University of Colorado Boulder agriculture, and the growing industry. They also learn about the diverse tools of modern biology, including recombinant DNA, Cech, Thomas R. (https://experts.colorado.edu/display/fisid_103252/) genomic mapping, transgenic , targeting, analysis of Distinguished Professor; PhD, University of California, Berkeley mutants, biochemical purification, antibody probes, laser manipulation of living cells, light and electron microscopy, and computer modeling. In Chen, Zhe (https://experts.colorado.edu/display/fisid_148754/) addition to academic and laboratory classes, MCDB majors have many Assistant Research Professor; PhD, University of Colorado Boulder opportunities to participate in ongoing research in the department. Copley, Shelley (https://experts.colorado.edu/display/fisid_104067/) Learn how operate at the cellular and molecular levels Professor; PhD, Harvard University of organization, their assembly and structure, with heavy emphasis on DeDecker, Brian S. (https://experts.colorado.edu/display/fisid_143934/) genetic information and regulation, including . Senior Instructor; PhD, Yale University Course code for this program is MCDB. Detweiler, Corrella Scott (https://experts.colorado.edu/display/ fisid_128240/) Use Policy Associate Professor; PhD, University of California, San Francisco Biology is the science of , and a major in it must include some hands- on experience with living organisms to be complete. Exercises involving Donaldson, Zoe Rebecca (https://experts.colorado.edu/display/ the use of living or animal tissues are included, therefore, in fisid_157087/) MCDB laboratory courses. Majors with objections on moral grounds Assistant Professor; PhD, Emory University may arrange to limit their participation in these exercises, although their Dowell, Robin D. (https://experts.colorado.edu/display/fisid_147779/) educational experience is compromised by doing so. Associate Professor; DSc, Washington University Nonmajors may take MCD biology lecture courses without the Dubin, Mark W. accompanying laboratories. Laboratory courses in which living vertebrate Professor Emeritus animals or tissues are used are identified in the course description section of this catalog. For additional information, please contact the Espinosa, Joaquin Maximiliano (https://experts.colorado.edu/display/ department. fisid_134378/) Visiting Associate Professor; PhD, Univ of Buenos Aires (Argentina) Bachelor's Degree Fillman, Christy L. (https://experts.colorado.edu/display/fisid_145115/) • Molecular, Cellular and Developmental Biology - Bachelor of Arts Senior Instructor; PhD, University of Colorado Boulder (BA) (catalog.colorado.edu/undergraduate/colleges-schools/arts- sciences/programs-study/molecular-cellular-developmental-biology/ Garcea, Robert L. (https://experts.colorado.edu/display/fisid_146103/) molecular-cellular-developmental-biology-bachelor-arts-ba/) Professor; MD, University of California, San Francisco Gold, Lawrence (https://experts.colorado.edu/display/fisid_100581/) Professor; PhD, University of Connecticut • Molecular, Cellular and Developmental Biology - Minor (catalog.colorado.edu/undergraduate/colleges-schools/arts- Guild, Nancy Ann sciences/programs-study/molecular-cellular-developmental-biology/ Professor Attendant Rank; PhD, University of Colorado molecular-cellular-developmental-biology-minor/) Han, Min (https://experts.colorado.edu/display/fisid_105512/) Faculty Professor; PhD, University of California, Los Angeles While many faculty teach both undergraduate and graduate students, Harvey, Pamela Ann (https://experts.colorado.edu/display/fisid_148012/) some instruct students at the undergraduate level only. For more Instructor; PhD, Tufts University information, contact the faculty member's home department. Hoenger, Andreas (https://experts.colorado.edu/display/fisid_142883/) Abbott, Lois A. Professor; PhD, Universität Basel (Switzerland) Senior Instructor Emerita 2 Molecular, Cellular and Developmental Biology

Jones, Kevin Robert (https://experts.colorado.edu/display/fisid_102094/) Perkins, Thomas T. (https://experts.colorado.edu/display/fisid_124578/) Associate Professor; PhD, University of California, Berkeley Associate Professor Adjoint; PhD, Stanford University

Junge, Harald Jobst (https://experts.colorado.edu/display/fisid_148593/) Runner, Meredith Assistant Professor; PhD, Philipps-Universität Marburg (Germany) Professor Emeritus

Klymkowsky, Michael W. (https://experts.colorado.edu/display/ Sawyer, Sara Lea (https://experts.colorado.edu/display/fisid_155218/) fisid_101226/) Associate Professor; PhD, Cornell University Professor; PhD, California Institute of Technology Shen, Jingshi (https://experts.colorado.edu/display/fisid_146414/) Knight, Jennifer Kirsten (https://experts.colorado.edu/display/ Associate Professor; PhD, Columbia University fisid_101933/) Associate Professor; PhD, University of Michigan Ann Arbor Singh, Ravinder (https://experts.colorado.edu/display/fisid_112067/) Associate Professor; PhD, Baylor College of Medicine Kralj, Joel M. (https://experts.colorado.edu/display/fisid_153055/) Assistant Professor; PhD, Boston University Staehelin, L. Andrew Professor Emeritus Krauter, Kenneth S. (https://experts.colorado.edu/display/fisid_107978/) Professor; PhD, Yeshiva University Stowell, Michael (https://experts.colorado.edu/display/fisid_124136/) Associate Professor; PhD, California Institute of Technology Kuempel, Peter L. Professor Emeritus Su, Tin Tin (https://experts.colorado.edu/display/fisid_113847/) Professor, Chair; PhD, Carnegie Mellon University Leinwand, Leslie Anne (https://experts.colorado.edu/display/ fisid_107104/) Sueoka, Noboru Distinguished Professor, Faculty Director; PhD, Yale University Professor Emeritus

Martin, Jennifer Mary (https://experts.colorado.edu/display/ Van Blerkom, Jonathan (https://experts.colorado.edu/display/ fisid_110125/) fisid_100545/) Senior Instructor; PhD, University of Washington Research Professor; PhD, University of Colorado Boulder

Mastronarde, David N. Vigers, Alison Jane (https://experts.colorado.edu/display/fisid_142378/) Professor Attendant Rank; PhD, University of Colorado Instructor; PhD, University of Colorado Denver

McConkey, Edwin H. Voeltz, Gia Kaarina (https://experts.colorado.edu/display/fisid_143587/) Professor Emeritus Professor; PhD, Yale University

McIntosh, J. Richard Weaver, Benjamin Distinguished Professor Emeritus Assistant Professor; PhD, University of Kansas

Niswander, Lee (https://experts.colorado.edu/display/fisid_160024/) Wood, William B. III Chair, Professor; PhD, Case Western Reserve University Distinguished Professor Emeritus

Odorizzi, Charles Gregory (https://experts.colorado.edu/display/ Xue, Ding (https://experts.colorado.edu/display/fisid_112336/) fisid_118429/) Professor; PhD, Columbia University Professor; PhD, University of California, San Diego Yarus, Michael J. Old, William (https://experts.colorado.edu/display/fisid_103039/) Professor Emeritus Assistant Professor; PhD, University of Colorado Boulder Courses Olwin, Bradley Bruce (https://experts.colorado.edu/display/ MCDB 1020 (1) Introduction to Molecular, Cellular and Developmental fisid_109888/) Biology Major Professor, Associate Chair; PhD, University of Washington Introduces students to the Molecular and Cellular Biology major. Provides Orth, James D. (https://experts.colorado.edu/display/fisid_152017/) an overview of the major and how it differs from other CU biology Assistant Research Professor; PhD, Mayo Graduate School of Medicine programs; how to get involved in clubs, research, and/or internship opportunities; strategies for succeeding in MCDB courses; and career Pace, Norman R. options. This is a first-year colloquium course specifically designed for Distinguished Professor Emeritus freshman and other students exploring their educational and career opportunities in our department. Park, Soyeon (https://experts.colorado.edu/display/fisid_151944/) Recommended: New MCDB majors. Assistant Professor; PhD, Mayo Graduate School of Medicine Grading Basis: Pass/Fail Parker, Roy Robert (https://experts.colorado.edu/display/fisid_151440/) Distinguished Professor; PhD, University of California, San Francisco Molecular, Cellular and Developmental Biology 3

MCDB 1030 (3) Introduction to MCDB 1150 (3) Introduction to Cellular and Molecular Biology Introduces the foundation of molecular, , developmental and Covers biologically important macromolecules and biological processes, in the context of human development and disease. together with an introduction to cell structure, , and . Including how the immune system works to protect us from infections Provides the foundation for advanced MCDB courses to majors, and a and technologies being developed towards the goal of better health rigorous overview of modern biology to non-majors. around the world. For nonmajors. Equivalent - Duplicate Degree Credit Not Granted: MCDB 1111 Additional Information: GT Pathways: GT-SC2 -Natural Physicl Sci:Lec Recommended: Prerequisite high school chemistry and algebra, and Crse w/o Req Lab recommended corequisite of MCDB 1152. Arts Sci Core Curr: Natural Science Sequence Additional Information: GT Pathways: GT-SC2 -Natural Physicl Sci:Lec Arts Sci Gen Ed: Distribution-Natural Sciences Crse w/o Req Lab MAPS Course: Natural Science Arts Sci Core Curr: Natural Science Sequence MCDB 1041 (3) Fundamentals of Human Arts Sci Gen Ed: Distribution-Natural Sciences Covers the basic principles of genetics, human pedigree analysis, MAPS Course: Natural Science Lab or Lab/Lec and how genetic diseases affect DNA, RNA, and proteins. Considers MCDB 1152 (1) Problem Solving Co-Seminar for Introduction to implications of this research for medicine and society. For nonmajors. Molecular and Cellular Biology Recommended: Requisite good background in high school chemistry and Uses problem solving and other interactive group work to aid student biology. learning in a corequisite course, MCDB 1150. Students will work in small Additional Information: GT Pathways: GT-SC2 -Natural Physicl Sci:Lec groups on learning and practicing how to solve difficult conceptual Crse w/o Req Lab problems, as well as using hands-on activities and concept mapping to Arts Sci Core Curr: Natural Science Sequence help learn content. Arts Sci Gen Ed: Distribution-Natural Sciences Recommended: Corequisite MCDB 1150. MAPS Course: Natural Science Grading Basis: Pass/Fail MCDB 1043 (1) Exploring Genetics Laboratory MCDB 1161 (2) From Dirt to DNA: Phage Laboratory I Provides hands-on experience with fundamental genetic principles. Provides laboratory experience working on a bacteriophage genomics Topics include scientific method, experimental design, , meiosis, research project. Students will study novel bacteriophage they isolate classical genetics, , mutagenesis, DNA analysis, and from the environment. Topics covered include phage biology, transgenic organisms. Wherever possible, the focus of the lab will be on and phage culturing and amplification, DNA isolation, restriction digest integrating science process skills with human-relevant experiments to analysis, agarose gel electrophoresis, and electron microscopy. encourage students to learn and apply science skills while seeing the Recommended: Prerequisites or corequisites: MCDB 1150 or EBIO 1210. application to humans. Grading Basis: Letter Grade Requisites: Restricted to Biological Sciences (MCDB) non-majors only. Additional Information: Arts Sci Core Curr: Natural Science Lab Recommended: Corequisite MCDB 1041. Arts Sci Gen Ed: Distribution-Natural Sci Lab Additional Information: Arts Sci Core Curr: Natural Science Lab Arts Sci Gen Ed: Distribution-Natural Sciences Arts Sci Gen Ed: Distribution-Natural Sci Lab MAPS Course: Natural Science Lab or Lab/Lec Arts Sci Gen Ed: Distribution-Natural Sciences MCDB 1171 (2) Drug Discovery Through Hands-on Screens I MAPS Course: Natural Science Lab or Lab/Lec Provides introductory research and laboratory experience. Students will MCDB 1111 (3) Core Concepts in Biology I: Evolutionary, Molecular and work in teams to screen small molecule libraries for novel antibiotics using the bacterium Salmonella as a model system. Topics covered Web-based, in-class discussion course covering the fundamental include the basic biology of the model system, genetics, approaches properties shaping living systems. Uses evolutionary (including social) to screening for new therapeutics, statistical analysis of the data, and physical-chemical mechanisms to frame molecular, cellular and compound verification and lead compound development. organismic processes. Interpreting and answering questions scientifically Recommended: Prerequisite or corequisite MCBD 1150 or EBIO 1210. as well as quantitative reasoning skills are stressed. Fulfills the MCDB Grading Basis: Letter Grade major's requirement for MCDB 1150. Additional Information: Arts Sci Core Curr: Natural Science Lab Equivalent - Duplicate Degree Credit Not Granted: MCDB 1150 Arts Sci Gen Ed: Distribution-Natural Sci Lab Additional Information: Arts Sci Core Curr: Natural Science Sequence Arts Sci Gen Ed: Distribution-Natural Sciences Arts Sci Gen Ed: Distribution-Natural Sciences MAPS Course: Natural Science Lab or Lab/Lec MAPS Course: Natural Science MCDB 1181 (2) Biological Probiotic/Drug Discovery Through Hands-on Screens Provides introduction to research and laboratory experience. Students will work in teams to screen novel mycobacterial strains for use as probiotics or immunoregulatory/anti-inflammatory drugs using THP-1 cells, a human monocytic cell line. Topics covered include the hygiene or "Old Friends" hypothesis, the human microbiome, approaches to screening for new probiotics of therapeutics and statistical analysis of the data. Equivalent - Duplicate Degree Credit Not Granted: IPHY 1181 Grading Basis: Letter Grade 4 Molecular, Cellular and Developmental Biology

MCDB 1234 (1-9) Skills Center: Modular Laboratory of Modern Molecular MCDB 2200 (3) Introduction to Biophysical Methods: From Brains to Biology Skills Bonds Dedicated to teaching students fundamental laboratory skills in Provides a practical overview of modern biophysical methods used to modern molecular biology. The skills are updated on a rolling basis in study biological systems from whole body imaging methods to methods consultation with MCDB faculty and local Pharma/Biotech companies for investigating single molecules and molecular bonds. The goal of this in an effort to provide students with real world skills that can help course is to provide a broad survey of methods available to the modern them transition from a traditional lab course environment to a more rather than a complete in-depth treatment of the physics and independent research environment. Credit hours are determined mathematics of each individual method. according to the Colorado Department of Higher Education guidelines Requisites: Requires prerequisite course of MCDB 1150 or EBIO 1210 such that 12.5 module hours equals one university credit hour. Students (minimum grade C-). can mix and match various skills to receive one or more university credit MCDB 2222 (3) Core Concepts in Biology II: , Genetics and hours and students who successfully complete a module are given a certificate recognizing their competency. Web-based, in-class discussion course focused on the origins of genetic Repeatable: Repeatable for up to 15.00 total credit hours. variation and inheritance, dynamics and and MCDB 2150 (3) Principles of Genetics their relationship to (s). Interpreting, explaining and answering Introduces the behavior of genes and chromosomes in eukaryotic and questions scientifically as well as quantitative reasoning are stress. prokaryotic organisms. Covers three areas: transmission genetics, Course fulfills the departmental requirement for MCDB 2150. molecular genetics, and population genetics. Attention is given to genetic Equivalent - Duplicate Degree Credit Not Granted: MCDB 2150 mapping, recombinant DNA procedures, and gene expression. Requisites: Requires a prerequisite course of MCDB 1111 or MCDB 1150 Equivalent - Duplicate Degree Credit Not Granted: MCDB 2222 (minimum grade C-). Recommended: Prerequisite MCDB 1150 or EBIO 1210 or CHEN 2810 Grading Basis: Letter Grade (minimum grade C-) and recommended corequisite of MCDB 2152. Additional Information: Arts Sci Core Curr: Natural Science Sequence Additional Information: GT Pathways: GT-SC2 -Natural Physicl Sci:Lec Arts Sci Gen Ed: Distribution-Natural Sciences Crse w/o Req Lab MCDB 2350 (3) Understanding Cancer: Introduction to the disease¿s Arts Sci Core Curr: Natural Science Sequence biology, medicine, and societal implications Arts Sci Gen Ed: Distribution-Natural Sciences A course for students who want to learn about cancer but have little or MCDB 2152 (1) Problem Solving Co-Seminars for Genetics no background in biology. It is based on a text that presents relevant Uses problem solving and other interactive group work to aid student science and medicine in a readable and comprehensible way. Classes will learning in MCDB 2150. Students will work in small groups on learning be discussion of material from the text with weekly quizzes for feedback. and practicing how to solve difficult conceptual problems, as well as The ethics and economics of cancer treatments will be discussed, along using hands-on activities and concept mapping to help learn content. with ways to minimize one¿s own cancer risk and live with cancer if Recommended: Corequisite MCDB 2150. necessary. Grading Basis: Pass/Fail Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences MCDB 2161 (2) From DNA to Genes, Phage Genomics Laboratory II MCDB 2840 (1-3) Lower-Division Independent Study Provides laboratory experience working on a bacteriophage isolated Students with adequate prerequisites should take MCDB 4840. during the previous semester. Topics include , genome Repeatable: Repeatable for up to 8.00 total credit hours. annotation, open reading frame and RNA identification, BLAST analysis, MCDB 3000 (3) : Engineering Biomolecular Systems in and submission to a genomic database. the Laboratory Requisites: Requires prerequisite course of MCDB 1161 (minimum grade Hands-on research experience in engineering biological systems. C-). Students will design biological systems to address relevant medical Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences and environmental problems facing our society. They will learn how to MCDB 2171 (2) Drug Discovery Through Hands-On Screens 2 build their molecular designs in the lab using current synthetic biology Provides introductory research and laboratory experience. Students will techniques. Students will also learn how to critically evaluate current work in teams to screen molecule libraries using fruit flies as a model research in the field and effectively communicate their own research. system. Topics covered include the basic biology of the model system, Formerly offered as a special topics course. genetics, approaches to screening for new therapeutics, statistical Repeatable: Repeatable for up to 6.00 total credit hours. analysis of the data, compound verification and lead compound Requisites: Requires prerequisite courses of (MCDB 1150 and development. MCDB 2150) or CHEN 2810 (all minimum grade C). Recommended: Prerequisite or corequisite MCBD 1150 or EBIO 1210. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sci Lab Grading Basis: Letter Grade Additional Information: Arts Sci Core Curr: Natural Science Lab Arts Sci Gen Ed: Distribution-Natural Sci Lab Arts Sci Gen Ed: Distribution-Natural Sciences Molecular, Cellular and Developmental Biology 5

MCDB 3010 (2) Undergraduate Teaching in Course-Based Undergraduate MCDB 3160 (3) Infectious Disease Research Experiences Illustrate how cutting edge tools in genomics can be used to study, To address the need for more advanced and continued participation monitor and cure disease caused by new and re-emerging human in course-based research, MCDB 3010 is designed to train students pathogens such as SARS/MERS, Ebola virus, Neisseria meningitides, who have taken MCDB 1171 or MCDB 2171 or MCDB 4202 as teaching influenza virus and malaria parasites. Technologies covered will include assistants. The aim is to enhance the students' experience and genome sequencing, annotation, transcriptomics, phylogenetics and responsibilities in course-based research and to prepare them for genotyping of microbial populations. An integrated approach to this research and mentorship in a departmental or graduate laboratory. topic will be presented, with these concepts threaded throughout: natural Repeatable: Repeatable for up to 4.00 total credit hours. history and evolution of pathogens, molecular biology, , Requisites: Requires prerequisite course of MCDB 1171 or MCDB 2171 or , public health and clinical diagnosis. There may be some MCDB 1161 or MCDB 4202 (minimum grade B). overlap with material covered in MCDB 1030 and MCDB 4750. Grading Basis: Letter Grade Requisites: Requires prerequisite course of MCDB 2150 or EBIO 2070 MCDB 3105 (3) Antibiotics: Functions and Failures (minimum grade C-). Learn about treatments for infectious diseases, how the first antibiotics Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences were discovered, where they come from, how and why they work, and how MCDB 3171 (2) Advanced Discovery Based Lab - Antibiotics resistance develops. Understand how antibiotics make modern medicine Provides students an opportunity to expand upon the research they possible. Explore ways clinicians minimize the spread of resistance performed in the introductory level course, Drug Discovery Through to antibiotics. Examine how new antibiotics and other approaches to Hands on Screens I (MCDB 1171). Students will work in teams to validate treating infection are being developed. potential antibiotics against human pathogens. Topics include hit Requisites: Requires prerequisite course of MCDB 2150 (minimum grade validation, dose response, mechanism of action, applied statistical C). analysis, and an introduction to the primary literature. Grading Basis: Letter Grade Repeatable: Repeatable for up to 4.00 total credit hours. MCDB 3135 (3) Molecular Biology Requisites: Requires prerequisite course of MCDB 1171 (minimum grade Examines the central dogma of biology by discussing the most important C-). molecules in cells (DNA, RNA and protein) and how their synthesis (DNA Grading Basis: Letter Grade replication, transcription, RNA processing and translation) is regulated. MCDB 3300 (3) Personalized Medicine - Recent Advances in Diagnostics Incorporated into the discussion is how recombinant DNA techniques and Therapeutics are used to discover and dissect cellular processes, how to design and Time for personalized medicine is now. Attempts to learn from and interpret experiments, and understanding the limits of experiments to put the patient/person back into the equation because personalized draw conclusions. medicine, at its worst, does nothing personal at all. Discusses historical Requisites: Requires prerequisite courses of MCDB 2150 or EBIO 2070 perspective, recent advances in molecular biology and medicine and CHEM 1113 or CHEM 1400 or CHEN 1211 (all minimum grade C-). (including OMICS) in regards to diagnostics and therapeutics for selected Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences human diseases, and what the future holds for personalized medicine. MCDB 3140 (2) Cell Biology Laboratory Guest lectures (medical experts, patients, family members) will further Provides laboratory experience using microscopy, bioinformatics, DNA enrich the course. isolation, PCR and gel electrophoresis to study cell biology and gene Recommended: Prerequisites MCDB 2150 or EBIO 2070. expression in a model . Students will learn research skills such Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences as interpreting data and planning experiments. MCDB 3330 (3) Evolution and Creationism Recommended: Corequisite MCDB 3135 or MCDB 3145. Intensive lecture/discussion course on the interrelationships among Additional Information: Arts Sci Gen Ed: Distribution-Natural Sci Lab science, religion, and social policy. Includes historical and scientific Arts Sci Gen Ed: Distribution-Natural Sciences development of evolution theory, social /, and the MCDB 3145 (3) Cell Biology public perception of science. Examines intracellular mechanisms, including transport of ions and small Recommended: Prerequisite MCDB 1150 or EBIO 1210 (minimum grade molecules across membranes; protein targeting to organelles; membrane C-). trafficking between organelles; ; the cytoskeleton; and Additional Information: Arts Sci Core Curr: Natural Science Non-Sequence the cell cycle. Arts Sci Gen Ed: Distribution-Natural Sciences Requisites: Requires prerequisite courses of (MCDB 2150 or EBIO 2070) MCDB 3332 (1) Scientific Ethics and (CHEM 1113 or CHEM 1400 or CHEN 1211) (all minimum grade C-). A reading/discussion course on the implications of modern biologically- Recommended: Prerequisite or corequisite MCDB 3140 concurrent with based technologies, from in vitro fertilization and its variants and issues either this class or MCDB 3135. surrounding these techniques, to genomic testing of and Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences , the of organisms, including humans, to MCDB 3150 (3) Biology of the Cancer Cell issues surrounding communicable diseases and vaccination. Discussion Highlights dimensions of the cancer problem; cancer as a genetic/cellular will include a serious consideration of various philosophical and non- disease; chemicals, viruses, and radiation as causes of cancer; cancer scientific perspectives. and diet; cancer epidemiology; cancer risk factors; proto-oncogenes, Requisites: Requires prerequisite course of MCDB 1150 or EBIO 1210 oncogenes, and cancer suppressor genes; and prevention of cancer. (minimum grade C). Restricted to students with 57-180 credits (Juniors or Recommended: Prerequisite MCDB 2150 or EBIO 2070 (minimum grade Seniors). C-). Grading Basis: Letter Grade Additional Information: Arts Sci Core Curr: Natural Science Non-Sequence Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Arts Sci Gen Ed: Distribution-Natural Sciences 6 Molecular, Cellular and Developmental Biology

MCDB 3333 (3) Biomedical Innovations and Discoveries MCDB 3651 (3) The Brain: Dysfunction to Disease Discusses how biological inventions and discoveries fuel biomedical Misregulation of synaptic function results in abnormal brain function and innovations, how important techniques in molecular biology have behavior that is manifested in numerous neurological and psychiatric advanced our understanding of cellular processes and contributed diseases. Explores the molecular mechanisms responsible for altered to biotechnology revolution and to benefit our synaptic plasticity in neurological diseases such as frontotemporal society. Guest lectures from experts in industry and site visits will dementia (FTD), Parkinson's disease, Huntington's disease, Creutzfeldt- enhance the course by providing a non-academic perspective, networking Jakob disease, Down syndrome, epilepsy, autism, and Alzheimer's opportunities, and unexpected avenues for career paths for our disease. graduates. Department enforced prerequisite: MCDB 2150 or EBIO 2070 Recommended: Prerequisites MCDB 3650 or NRSC 2100 (minimum grade or instructor consent. C-) or instructor consent required. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Grading Basis: Letter Grade MCDB 3350 (3) Fertility, Sterility, and Early Mammalian Development Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Describes the production of germ cells, ovulation, fertilization, MCDB 3700 (3) Poisons in Cell Biology and Society reproductive cycles, controls of , early development of Investigate the inner workings of our cells by studying how poisons the , methods of contraception, and causes and treatments disrupt these processes. We will learn how selected poisons affect of sterility. Recommended for students planning careers in the health critical processes inside the cell to cause or destruction. The sciences. scientific aspects of the poison will be discussed in the context of its Recommended: Prerequisite MCDB 1150 or EBIO 1210 (minimum grade historical significance or impact on society and popular culture. C-). Requisites: Requires prerequisite course of MCDB 2150 or EBIO 2070 (all Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences minimum grade C-). MCDB 3450 (3) Biological Data Science Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences The central function of data science is to extract information from MCDB 3990 (3) Introduction to Systems Biololgy for complex datasets. Biology is an increasingly large-data endeavor with Introduces majors with relatively little mathematical experience to the health care records, genomics datasets, and extensive imaging. This major concepts in , in the context of key processes (cell course will develop core data science skills, including statistical analysis, growth, division, , development, and disease). Designed to help visualization, data management, machine learning, and modeling. students master the necessary mathematical tools involved. Recommended: Prerequisite MCDB 2150 or EBIO 2070 (minimum grade Recommended: Prerequisites MCDB 3135 and MCDB 3145 and C-), or exposure to probability theory. MATH 1310 (minimum grade C-). Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Grading Basis: Letter Grade MCDB 3501 (3) Structural Methods for Biological Macromolecules Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Teaches fundamental knowledge about protein structures, protein MCDB 4100 (1-6) Special Topics interactions and protein folding. Discusses in detail the most common Repeatable: Repeatable for up to 6.00 total credit hours. Allows multiple methods on how proteins and macromolecular complexes are studied, enrollment in term. such as X-ray crystallography, NMR-spectroscopy and electron Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum microscopy. Offers about 50 percent direct teaching, 40 percent grade C-). discussion of papers in a journal club style and 10 percent hands-on Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences practicals on software packages relevant to . Formerly MCDB 4101 (3) Manipulating -Discovering Gene Functions MCDB 4501. Discover novel gene function in vertebrate embryonic development using Recommended: Prerequisite MCDB 2150 or EBIO 2070 (minimum grade the latest gene-editing technology, CRISPR-Cas9. Pick your gene of C-). interest and design experiments to mutate the gene, confirm the mutation Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences and characterize the phenotype. Search scientific databases to learn MCDB 3650 (3) The Brain - From Molecules to Behavior more about the gene and formulate a hypothesis about the gene function. Examines the molecular basis of the brain's role in thought, action, and Discuss and present your findings to your peer and faculty. consciousness by exploring issues such as relationship of cognition Recommended: Prerequisites MCDB 3135 and MCDB 3145. and localized brain function, sensory systems and their role in cognition, Grading Basis: Letter Grade learning and memory, and behavioral neurochemistry. MCDB 4105 (3) Function of Cellular and Nuclear, Assemblies, and Recommended: Prerequisite MCDB 2150 or EBIO 2070 (minimum grade Machines C-). Maintaining cellular functions requires a coordinated interaction of all Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences kinds of organelles, assemblies and machines. This course will explore the structure, function, regulation and interactions of cellular organelles, supramolecular assemblies, and molecular machines (motors, ribosomes, polymerases, channels, etc.). Students will be exposed to a set of lectures and prepare specific papers that will be discussed in the group. Grading Basis: Letter Grade Molecular, Cellular and Developmental Biology 7

MCDB 4111 (3) Experimental Design and Research in Cell and Molecular MCDB 4202 (3) The Python Project Biology Studies how python hearts grow after they consume a meal. Learning molecular and cell biology experimental design and approaches Understanding the molecular processes of growth and regression in through independent research projects. Students, working in pairs, will the python heart could lead to development of therapeutics for heart explore the research process and gain extensive first-hand experience disease. Students work in groups in the laboratory and generate novel in: hypothesis formation; experimental design; solution preparation and data by using modern molecular biology and bioinformatic techniques to experimental methodology; proposal presentation and defense (oral and clone and sequence candidate molecules of the python genome. May be written); formal presentation of results and conclusions (oral and written repeated once. in a publication-style format); the publication process; critical reading and Repeatable: Repeatable for up to 6.00 total credit hours. evaluation of primary scientific literature. Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum Recommended: Prerequisite MCDB 1150 or EBIO 1210 (minimum grade grade C-). C-) and recommended corequisite of MCDB 3135. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences MCDB 4234 (3) Research Methods MCDB 4150 (3) Biology of Aging and Presents a rigorous and pedagogically coherent introduction into the Through lectures and reading assignments, this capstone course experimental process used to collect data, formulate hypotheses, will introduce fascinating cellular and molecular mechanisms and answer scientific questions in general, and biological questions underlying aging and longevity based on historical and recent research in particular. Includes a detailed consideration of the elements of achievements. We will discuss major aging theories and multiple cellular experimental design, data collection and analysis, and the interpretation regulatory systems that prominently affect lifespan. The course will of results in the context of effective science teaching. Part of the integrate basic concepts from multiple other courses by addressing CU Teach course sequence for teacher certification in science and specific physiological problems in the aging field and present students mathematics. with the opportunity to learn the reasoning process in cutting-edge Requisites: Restricted to Biological Sciences (MCDB) majors or School of biomedical research. Education (EDUC) undergraduate students only. Requisites: Requires prerequisite courses of (MCDB 1150 or EBIO 1210) Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum AND (MCDB 2150 or EBIO 2070) (minimum grade of C-). grade C-). Recommended: Prerequisite MCDB 3135 or MCDB 3145 (minimum grade Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences C-). MCDB 4300 (3) Immunology MCDB 4185 (3) Geomicrobiology Emphasizes cellular and molecular mechanisms by which organisms Examines how microbial and chemical processes interact on the Earth¿s protect themselves from pathogens and the experimental basis for our surface today and have shaped the planet throughout its history. understanding of these processes. Discusses development, function, Emphasis will be placed on how the life styles and chemical ingenuity and misfunction of t-cells, b-cells and other components of the immune of drive key biogeochemical processes including system, focusing on the human immune system. weathering and transformations of carbon, oxygen, sulfur, iron and Equivalent - Duplicate Degree Credit Not Granted: MCDB 5301 nitrogen. Towards this goal, major geologic and evolutionary events will Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum be examined through the lens of microbial diversity, metabolic energetics, grade C-). microbe-mineral interactions, and molecular biomarkers. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Equivalent - Duplicate Degree Credit Not Granted: GEOL 5185, MCDB 4310 (3) Microbial Genetics and Physiology ENVS 4185, and GEOL 4185 Examines the physiology and genetics of bacteria, and viruses. Requisites: Requires prerequisite courses of CHEM 1113 and CHEM 1114 Particular emphasis will be on , regulation of gene expression or CHEM 1400 and CHEM 1401 (minimum grade D-). and protein function, mechanisms of interactions with and manipulation Recommended: Prerequisites GEOL 1180 or MCDB 1150 or GEOL 3320 or of the environment, and evolution in response to environmental EBIO 3400 or ENVS 4160 or EVEN 4484. pressures. Grading Basis: Letter Grade Equivalent - Duplicate Degree Credit Not Granted: MCDB 5310 MCDB 4201 (3) From Bench to Bedside: The Role of Science in Medicine Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum Demonstrates the breadth of research in the life sciences and how such grade C-) and recommended corequisite of CHEM 4611. research (not just in medical schools) can lead to medical applications. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Lecturers from life sciences, the medical school and biotechnology, MCDB 4312 (3) Quantitative Optical Imaging discuss drug development and the transfer of research into the Explores the fundamentals of optical imaging in biology, especially clinical arena. Students also prepare a paper and presentation on the molecular and cellular biology. Covered topics include an introduction to development of a commercial drug. optics and microscopes, fluorescence microscopy and image analysis, Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum and biological applications. MATLAB will be taught at the beginning of grade C-). the course and used throughout for image processing. Prior experience Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences with MATLAB (or Python) is highly recommended but not required. Equivalent - Duplicate Degree Credit Not Granted: BCHM 4312, MCDB 5312 and BCHM 5312 Grading Basis: Letter Grade Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences 8 Molecular, Cellular and Developmental Biology

MCDB 4350 (3) Microbial Diversity and the Biosphere MCDB 4425 (3) Topics in Membrane Biology: Cell Biology, Physiology and Provides a molecular phylogeny-based perspective on microbial diversity Disease and the interactions between organisms that result in the biosphere. Students will apply their knowledge of basic biology to exploring several Provides overview of recent methods and findings in microbial , as of the most exciting topics in biomedicine including protein folding and well as computer-based workshop in molecular phylogeny. Fulfills MCDB stress responses, nutrient sensing and balance and signal transduction scientific reasoning requirement. across membranes. Emphasis will be placed upon human physiology and Equivalent - Duplicate Degree Credit Not Granted: MCDB 5350 associated human diseases including Alzheimer's disease, diabetes and Recommended: Prerequisites MCDB 1150 or EBIO 1210 and CHEM 1133 cardiovascular disease. Fulfills MCDB scientific reasoning requirement. and EBIO 3400 and/or CHEM 3311 (minimum grade C-). Equivalent - Duplicate Degree Credit Not Granted: MCDB 5425 Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Recommended: Prerequisites MCDB 3135 and MCDB 3145 or instructor MCDB 4361 (3) Evolution and Development consent. Relates how recent discoveries in the molecular mechanisms of Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences development are shaping our understanding of animal evolution. Reviews MCDB 4426 (3) and Developmental Regulation basic principles of molecular developmental biology and applies these Introduces several cell signaling processes and their biological functions. concepts to critically discuss current research in the field of Evo- Students read and analyze original research articles to learn the Devo (evolution and development). Fulfills MCDB scientific reasoning thinking processes of scientific research. Writing assignments and requirement. oral presentations are required. Fulfills MCDB scientific reasoning Equivalent - Duplicate Degree Credit Not Granted: MCDB 5361 requirement. Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum Equivalent - Duplicate Degree Credit Not Granted: MCDB 5426 grade C-). Recommended: Prerequisites MCDB 3135 and MCDB 3145 and CHEM Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences 4700 (minimum grade C-). MCDB 4410 (3) Human Molecular Genetics Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Studies the human organism as a genetic system, including effect of MCDB 4427 (3) Biology of the Visual System mutation on protein structure and function, biochemical basis of human Explores the neurobiology, cell biology, genetics and developmental genetic disease, polymorphic gene loci, gene mapping and identification, biology of the visual system. Discusses neurodegenerative and vascular gene cloning and characterization, and impact of on diseases that lead to blindness. Students read and analyze original medicine and society. Fulfills MCDB scientific reasoning requirement. research articles to train scientific reasoning. Involves student-organized Recommended: Prerequisite MCDB 3135 (minimum grade C-). presentations and classroom discussion. Fulfills MCDB scientific Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences reasoning requirement. MCDB 4420 (3) Genetics of Brain and Behavior Equivalent - Duplicate Degree Credit Not Granted: MCDB 5427 Examines the genetic underpinnings of animal behavior, including an Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum examination of behavioral evolution and the use of genes as tools to grade C-) or instructor consent required. examine neural architecture. We will cover topics including foraging, Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences social behavior, personality, parental care and fear. We will explore these MCDB 4428 (3) Regulation of Lifespan behaviors at multiple levels, including genomics, population genetics, Lectures and literature reading/discussion will introduce students to molecular genetics, , endocrinology and neurobiology. Fulfills historical, fascinating and cutting-edge research achievements, as well MCDB scientific reasoning requirement. as the basic genetic/biochemical approaches, towards understanding Equivalent - Duplicate Degree Credit Not Granted: NRSC 4420 cellular signaling systems and mechanisms that regulate the aging Requisites: Requires prerequisite courses of NRSC 2100 and EBIO 2070 process and lifespan of animals and humans. Through the combination or (MCDB 2150 and (MCDB 1161 or MCDB 1171 or MCDB 1181 or of presentation, discussion, homework and two exams, students will MCDB 2171)) (all minimum grade C). learn the reasoning process of scientific research in the aging field, Grading Basis: Letter Grade become familiar with typical experimental approaches and improve their MCDB 4422 (3) Molecular Biology of Free Radicals: Role(s) in Oxidative communication ability. Stress, Signaling, Disease, Aging Requisites: Requires prerequisite course of MCDB 3135 (minimum grade Examines how free radicals are formed in biological systems and their C-). roles in oxidative stress, cell signalling, aging, and disease. Emphasis Grading Basis: Letter Grade will be placed on the recent literature. Fulfills MCDB scientific reasoning MCDB 4441 (4) Animal Developmental Diversity requirement. Surveys development in a range of vertebrate and invertebrate systems Recommended: Prerequisites MCDB 3135 and MCDB 3145 and to reconstruct the common bilatorian ancestor, and elucidate the CHEM 3311 (minimum grade C-). developmental genetic changes underlying animal diversification. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Lab focuses on vertebrate embryos and explores key methods in evolutionary developmental biology including in situ hybridization, embryo microinjection, and transgenesis. Equivalent - Duplicate Degree Credit Not Granted: MCDB 5441 and EBIO 4440 and EBIO 5440 Recommended: Prerequisites MCDB 1150 or EBIO 1210 and MCDB 2150 or EBIO 2070 (minimum grade C-). Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Arts Sci Gen Ed: Distribution-Natural Sci Lab Molecular, Cellular and Developmental Biology 9

MCDB 4444 (3) Cellular Basis of Disease MCDB 4560 (3) Introduction to Explores the cellular basis of disease. Discusses diseases arising from Covers an introduction to the physics of living systems. Focuses on how defects in intracellular targeting, cytoskeletal function, intracellular living systems are able to generate order, with both physical principles signaling, genomic instability, gene regulation, , and and biological examples. Covers the development of quantitative models cell death. Involves student-organized presentations and classroom for biological systems, including estimates. Taught from a physics discussion. Fulfills MCDB scientific reasoning requirement. perspective, with biology background introduced as needed. Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum Equivalent - Duplicate Degree Credit Not Granted: MCDB 5560 and grade C-). PHYS 4560 and PHYS 5560 Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Requisites: Requires a prerequisites course of PHYS 2210 (minimum MCDB 4471 (3) Mechanisms of Gene Regulation in grade C-). Focuses on manifestations of regulated gene expression. Studies gene Recommended: Prerequisite PHYS 4230. regulation at multiple steps, including transcription, RNA processing Grading Basis: Letter Grade and translation. Is based on critical analysis of primary research papers. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Written assignments and oral presentations are required. Fulfills MCDB MCDB 4615 (3) Biology of Stem Cells scientific reasoning requirement. Stem cells have received considerable notice in both the scientific and Equivalent - Duplicate Degree Credit Not Granted: MCDB 5471 social arena. Examines the concept by a critical examination Recommended: Prerequisite MCDB 3135 (minimum grade C-) or of the primary scientific literature. Topics will include pluripotency and instructor consent required. plasticity, environment, technology, self-renewal, transdifferentiation, Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences molecular signature, epigenetic programming and stem cell versus MCDB 4520 (3) Bioinformatics and Genomics cancer cell. Fulfills MCDB scientific reasoning requirement. Computational and experimental methods in bioinformatics and Equivalent - Duplicate Degree Credit Not Granted: MCDB 5615 genomics, and how these methods provide insights into protein structure Recommended: Prerequisite MCDB 3135 or MCDB 3145 or instructor and function, molecular evolution, biological diversity, cell biology consent required. and human disease. Topics include database searching, multiple Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences sequence alignment, molecular phylogeny, microarrays, and MCDB 4621 (3) Genome Databases: Mining and Management pharmacogenomics. Develops essential skills for performing genomic analyses, with focus Equivalent - Duplicate Degree Credit Not Granted: MCDB 5520 on developing practical research tools. Introduces human genome and Recommended: Prerequisites MCDB 3135 or CHEM 4700 (minimum microbiome projects, Python/Sql scripting, accessing and understanding grade C-). genomic data, sequence alignment and search, evolutionary models, Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences expression data, biological networks, and macromolecular structure. MCDB 4521 (1) Bioinformatics and Genomics Laboratory Equivalent - Duplicate Degree Credit Not Granted: BCHM 4621, Provides experience with, and exposure to, computational and MCDB 5621 and BCHM 5621 experimental methods in bioinformatics and genomics. Meets once a Requisites: Requires prerequisite course of BCHM 2700 or BCHM 4700 or week. Students are expected to read original research papers, discuss CSCI 3104 or MCDB 3500 (minimum grade C-). findings, plan and execute data analysis in selected areas. Recommended: Prerequisite MCDB 3135 or CSCI 3104 or CHEM 4700 and Equivalent - Duplicate Degree Credit Not Granted: MCDB 5521 recommended corequisite of CSCI 2270. Grading Basis: Letter Grade Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences MCDB 4650 (3) Developmental Biology Arts Sci Gen Ed: Distribution-Natural Sci Lab Explores the development of invertebrate and vertebrate organisms, MCDB 4550 (3) Cells, Molecules and Tissues: A Biophysical Approach emphasizing cellular, molecular and genetic mechanisms. Focuses Focuses on the biophysics governing the structure/function of enzymes, on conceptual understanding and experimental approaches to topics cells, and . Synthesizes ideas from molecular such as , developmental control of gene expression in biology, physics, and , emphasizing how low Reynolds eukaryotic cells, mechanisms of differentiation and and number physics, not Newtonian physics, is relevant to life inside a cell. developmental genetics. Fulfills MCDB scientific reasoning requirement. Equivalent - Duplicate Degree Credit Not Granted: MCDB 5651 Equivalent - Duplicate Degree Credit Not Granted: MCDB 5550 and Requisites: Requires prerequisite courses of MCDB 3135 and MCDB 3145 PHYS 4550 and PHYS 5550 (minimum grade C-). Recommended: Prerequisites MCDB 3135 and MCDB 3145 and Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences PHYS 2010 and PHYS 2020 and CHEM 1133 and MATH 1300 and/or MCDB 4680 (3) Mechanisms of Aging CHEM 3311 (minimum grade C-) or instructor consent required. Studies aging as a developmental process emphasizing genetic, Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences cellular and molecular mechanisms. Fulfills MCDB scientific reasoning requirement. Equivalent - Duplicate Degree Credit Not Granted: MCDB 5680 Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum grade C-). Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences 10 Molecular, Cellular and Developmental Biology

MCDB 4750 (3) Animal MCDB 4811 (3) Teaching and Learning Biology Encompasses the structure and replication of both lytic and transforming Provides an introduction to recent research into student learning on the animal viruses. Emphasizes diversity of naturally occurring genomic conceptual foundations of modern biology, together with pedagogical structures and the resulting strategies of infection as well as the impact methods associated with effective instruction and its evaluation. of viral epidemics on society. Includes critical analysis of primary Students will be involved in active research into conceptual and practical research papers. Fulfills MCDB scientific reasoning requirement. issues involved in biology education, methods to discover student Equivalent - Duplicate Degree Credit Not Granted: MCDB 5750 preconceptions, and the design, testing and evaluation of various Recommended: Prerequisite MCDB 3135 (minimum grade C-) or instructional interventions. instructor consent required. Equivalent - Duplicate Degree Credit Not Granted: EDUC 6811 and Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences EDUC 4811 and MCDB 5811 and EBIO 4811 MCDB 4777 (3) Molecular Neurobiology Recommended: Prerequisites MCDB 1150 or EBIO 1210 and MCDB 2150 Introduces the functional of the nervous system and explores and MCDB 3145. current knowledge regarding the molecular and genetic basis of the Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences development and function of the nervous system. Studies recent insights MCDB 4840 (1-6) Upper-Division Independent Study into the molecular basis of neurodegenerative diseases, in the last An independent study contract is required. portion of the course. Repeatable: Repeatable for up to 8.00 total credit hours. Equivalent - Duplicate Degree Credit Not Granted: MCDB 5777 Recommended: Prerequisite MCDB 2150. Recommended: Prerequisites MCDB 3135 and MCDB 3145 (minimum MCDB 4900 (1-3) Public Health Practicum grade C-). Offers practical experience in Public Health with direct supervision. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences Equivalent - Duplicate Degree Credit Not Granted: EBIO 4900 and MCDB 4790 (3) Oocytes, Stem Cells, Organisms: Experiments to IPHY 4900 Discoveries Repeatable: Repeatable for up to 6.00 total credit hours. Develop critical thinking, scientific reasoning and communication skills MCDB 4960 (1) Research Communication: Analyzing Data and Effectively by reading and presenting primary research articles and Nobel Prize Communicating Science for Honors Students winning research on patterning, stem cells, cell death, genetic and This course is intended for MCDB honors students and to be taken epigenetic mechanisms that regulate embryonic development. Learn the same semester as their undergraduate thesis defense. The course about experimental approaches from a historical and present view, while will teach honors students how to analyze their research data with discussing their ethical implications. proper statistics and effectively write their undergraduate honors thesis. Grading Basis: Letter Grade Students will also gain experience in presenting their research to an Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences audience with constructive feedback given. MCDB 4800 (3) Molecular Evolution: How has Shaped Requisites: Requires prerequisite courses of MCDB 3135 and MCDB 3145 the Molecules of Life (minimum grade C-). This course explores how Darwin¿s idea has shaped the structures of MCDB 4980 (3) Honors Research DNA, RNA and proteins across the long history of life on earth. Natural Provides faculty-supervised research for students who have been selection driving the evolution these macromolecules and subsequent approved by the departmental honors committee. Normally taken during developmental pathways will be fully appreciated as the process that the semester before completion of the honors thesis. ultimately produced the amazing variety of species on this planet. Recommended: Prerequisite MCDB 4840 or comparable research Looking ahead, our recent efforts to harness the power of evolution in the experience, and minimum GPA of 3.20. test tube to develop new therapies will be covered. Additional Information: Arts Sciences Honors Course Requisites: Requires prerequisite courses of MCDB 3135 and MCDB 3145 (minimum grade C-). MCDB 4990 (3) Honors Thesis Involves the preparation and defense of an honors thesis, based on MCDB 4810 (3) Insane in the Membrane: The Biology and Biophysics of faculty-supervised original research, including final phases of the the Membrane research project. Studies the biology and physics of the biomembrane. Topics include Recommended: Prerequisites MCDB 4840 or MCDB 4980 or comparable structure and mechanism of membrane proteins; membrane biogenesis; research experience, and minimum GPA of 3.3 and approval by the MCDB membrane protein folding and stability; membrane ; Honors Committee. mechanisms of membrane fusion and fission; lipid trafficking. Fulfills Additional Information: Arts Sciences Honors Course MCDB scientific reasoning requirement. Recommended: Prerequisite CHEM 4700 (minimum grade C-) or instructor consent required. Additional Information: Arts Sci Gen Ed: Distribution-Natural Sciences