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Trioxsalen (4,5’,8-Trimethylpsoralen)

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Trioxsalen (4,5’,8-Trimethylpsoralen) InterBioTech FT-423807 Trioxsalen (4,5’,8-Trimethylpsoralen) Product Description Product Name: Trioxsalen (4,5’,8-Trimethylpsoralen) Synonyms: Trioxsalen; NSC 71047; 4,5’,8-Trimethylpsoralen; Trisoralen; 2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-on; Cat Number : 423807, 100mg 423808 , 500mg AX8HJ0, 1ml at 10mM in DMSO. CAS: 3902-71-4 Molecular Weight: 228.24 Purity (LCMS): >99% Solubility: in DMSO : 50 mg/mL (184.99 mM; Need ultrasonic) in H2O : < 0.1 mg/mL (insoluble) Targets: GAG; Collagen typeII Channel Pathway: - Storage: Powder : Store at -20°C for 3 years, at 4°C for 2 years (M) In solvent : Store at -80°C for 6 months, at -20°C for 1 month Description: Trioxsalen is a furanocoumarin and a psoralen derivative. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death. It is used in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. Technical and Scientific Information Biological activity: Like Psoralen (#AX6fA0), Trioxsalen intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light.[1][2]. Cross-links in DNA can cause programmed cell death. It is used to study DNA structure as well as the cellular response to DNA damage. It has been used in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. Trioxsalen and other psoralens photosensitize skin cells to ultraviolet light[3]. Protocol : Solvent and solubility Invitro A stock solution may be made by dissolving the trioxsalen in the solvent of choice. Trioxsalen is soluble in organic solvent such as dichloromethane, which should be purged with an inert gas. Preparing DMSO : 6.6 mg/mL (28.92 mM; Need ultrasonic and warming) solutions Mass 1 mg 5 mg 10 mg Concentration 1 mM 4.3814 mL 21.9068 mL 43.8135 mL 5 mM 0.8763 mL 4.3814 mL 8.7627 mL 10 mM 0.4381 mL 2.1907 mL 4.3814 mL Contact your local distributor BioSciences Innovations, powered by [email protected] P.1 InterBioTech FT-423807 References: [1].McNeill, D.R., Paramaslvam, M., Baldwin, J., et al. NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks. J. Biol. Chem.288(18), 12426-12436 (2013). [2].Iyama, T., Lee, S.Y., Berquist, B.R., et al. CSB interacts with SNM1A and promotes DNA interstrand crosslink processing. Nucleic Acids Res.43(1), 247-258 (2015). [3].Pathak, M.A., Marciani M.S., Guiotto, A., et al. A study of the relationship between photosensitizing and therapeutic activity of 4,5’,8- trimethylpsoralen, and its major metabolite 4,8-dimethyl, 5’-carboxypsoralen. J. Invest. Dermatol.81(6), 533-539 (1983). Related products 8-Geranyl-oxy-psoralen #BP391A (). CAS: 7437-55-0; MW:338.40 Bergamottin #B2UUT0 (). Synonyms: 5-Geranoxypsoralen; Bergamotine; Bergaptin) CAS: 7380-40-7; MW: 338.40; Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM. 6',7'-EpoxyBergamottin #DT905; A potent CYP3A4 inhibitor from grapefruit CAS No. 206978-14-5 (). dihydroxy6,7bergamottin (6,7-DHB) #MM837: CAS: 145414-76-2; A potent CYP3A4 inhibitor (). Ordering information Catalog size quantities and prices may be found at www.interchim.com. Please contact InterBioTech – Interchim for any other information Hotline : +33(0)4 70 03 73 06 – [email protected] Disclaimer : Materials are sold for research use only, and are not intended for food, drug, household, or cosmetic use. ® Interchim is not liable for any damage resulting from handling or contact with this product. Rev.U08E Contact your local distributor BioSciences Innovations, powered by [email protected] P.2 .
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